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Reflective magnetic Strips/Tapes for Worksite Vehicles!
Our reflective magnetic Strips/Tapes or Vehicle Identification Strips are best suited for worksite vehicles such as mining, construction, etc. that require high levels of reflection. High visibility magnetic tape is a versatile material commonly used for enhancing visibility and safety on vehicles.
Select product from our Online Shop.
Banner house Offers high quality Vehicle Signage at affordable prices and supply our products to all major cities including Perth, Melbourne, Sydney, Brisbane, Adelaide, Hobart, Darwin, Canberra and other regional towns.
#Magnetictape#vehiclestrip#selfadhesivetape#affordable#vehiclesignage#cartape#nonmagneticstrip#magneticstrip#bannerhouse#bannerhouseperth#bannerhouseaustralia
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Prima commissione di Gennaio 2024
Prima commissione dell’anno, Sally. Con Gennaio chiudo per un po’ i ritratti su commissione…riprenderò più in là, non so quando, tutto da definire, ma sicuramente proporrò qualcosa di nuovo…ho alcune idee che mi friggono in testa. Seguimi sui miei profili Instagram!
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#2024#animal portraits#animali#animali domestici#art#arte#arte animali#artisti su commissione#blog di arte#cartaper pastello#disegni#disegno a matita
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Aujourd'hui on a commencé par la vallée de l'arc-en-ciel. Une des plus belles choses que l'on ait vue. On y est resté avec de belles balades de 9 heures à 13 heures Ensuite départ pour le vallée de la mort avec une très belle dune, de beaux rochers mais une montée au mirador un peu décevante. On change de lieu pour la vallée de la Cartape avec sa gueule du diable assez beau et son église isolée San Isidro. Retour à l’hôtel, plongeon dans la piscine et repas dans un bar branché où la moyenne d'age est de 25 ans. A ne pas faire tous les jours.
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8 Head Gear Pump Filling Machine for
used for Organic Liquid Pesticides, Agrocultural Pesticides, Biopesticides, Organic Pesticides, Pest Control Chemicals, Cartap hydrochloride, Neem Insecticide, Profenofos, Chemical Pesticides, Fungicides, Fumigant, Organic Fungicide, Systemic Fungicide, Tebuconazole, Herbicides, Acaricide, Pesticide Intermediate, Bio Insecticides, Termiticide, Plant Growth Regulators, Agro Chemicals, Pest Control Chemicals, Selective Herbicide, Non Selective Herbicide, Rodenticides, Biofungicides, Nematicide, Permethrin, Bacillus Thuringiensis, Glyphosate, Organic Herbicides, Weedicide, Emamectin Benzoate, Cooking Oil, Mustard Oil, Soybean Oil, Cottonseed Oil, Vanaspati Ghee, Rice Bran Oil, Sesame Oil, Palm Oil, Mustard Oil, Kachi Ghani Mustard Oil, Refined Oil, Coconut Oil, Sunflower Oil, Corn Oil, Olive Oil, Soya Oil, Butter Oil, Fish Oil, Canola Oil, Safflower Oil, Oil Spray, Avocado Oil, Grape Seed Oil, Animal Oil, Crude Rice Bran Oil, Rapeseed Oil, Hydrogenated Vegetable Oil, Nut Oils, Organic Safflower Oil, Palm Oil, Groundnut Oil, Virgin Groundnut Oil, Virgin Coconut Oil, Edible Oil, Vegetable Oil, Tallow Oil, Onion Oleoresin, Nut Oils, Hazelnut Oil, Fish Oil, Cod Liver Oil, Salmon Oil, Shark Liver Oil, Engine Oil, Lubricating Oil, Gear Oil, Automotive Oils, Industrial Oils, Silicon Oil, Waste Oils, Oil Stabilizer, Mineral Oils, Brake Oil, Car Engine Oil, Face Cleanser, Sunscreen Lotion, Skin Serum, Hair Shampoo, Herbal Shampoo, Ayurvedic Hair Oil, Hair Oil, Herbal Hair Oil, Ayurvedic Hair Oil, Hair Growth Oil, Onion Hair Oil, Amla Hair Oil, Cool Hair Oil, Deep Cleansing Milk, Petroleum Jelly, Hair Tonic, Hair Lotion, Hair Serum, Herbal Body Lotion, Body Lotions, Moisturizing Lotion, Cosmetic Lotions, Massage Lotion, Liquid Sodium Silicate, Pyrithione Zinc, Nail Polish Remover, Nail Colour Gel, Raw Glycerine, Glycerine, Hair Conditioner, Skin Toner, Herbal Skin Toner, Skin Toning Milk, Hair Shampoo, Herbal Shampoo, Aloe Vera Shampoo, Disinfectant Chemicals, Cleaning Chemicals, Stain Removers, Liquid Cleaning Chemical, Cleaning Agent, Floor Cleaner, Phenyl, Phenyl, Liquid Cleaner, Tile Cleaner, Perfumed Floor Cleaner, Utensil Cleaner, Bathroom Cleaners, Surface Cleaner, Household Cleaners, White Phenyl, Black Phenyl, Green Phenyl, Liquid Bleach, Automotive Cleaners, Car Shampoos, Automotive Polish, Car Polish, Liquid Polish, Glass Cleaners, Vehicle Glass Cleaner, Carpet Shampoo
#manufacturer#shivshaktimachtech#8heafillingmachine#fillingmachine#liquidfillingmachine#liquidfillingmachinemanufacturer#autofillermachine#SSMfiller#dubai#fillingmachineindubai#gearpumpfillingmachine#servofillingmachine#oilfillingmachine#phenylephrine#floor cleaners#cleaning liquid#home cleaning liquid#exporter#manufacturing#technology#packagingmachinery#packaging market#saudiarabia#packaging machine manufacturer#packingmachine#packagingsolutions#packagingdesign#machine manufacturing
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Greetings, art tourists! You won't want to miss the last weekend of the Hwy 62 Open Studio Art Tours at the Copper Mountain College campus in Joshua Tree. We'll be open both Saturday and Sunday, October 21 & 22, from 10 a.m. to 5 p.m., and we have a special Saturday planned for you!
Stop by and see the Student Art Show & Sale, and on Saturday, October 21, you can catch some great live music too! Mariana & friends will be performing in the amphitheater at 11 a.m., with Pierce Marengo taking the stage at noon.
Pierce Marengo is a musician and vocalist from Southern California who recently released his debut album, California Cartapes. The album tells the story of his experience at age 12 dealing with severe OCD and hospitalization, as well as his rejoining of society just to learn more lessons from high school. California Cartapes is primarily rap music, and Pierce will be performing the story live at the Copper Mountain College Amphitheater.
While you're here, you can also take a guided campus art tour, add a memento to the 20,000 Roads interactive memorial, listen to some live music, and enjoy some great food from Jorge's cafe - all while your EV is charging up for the next part of the Art Tours.
But don't leave yet - the closing reception and Day of the Dead event takes place on Saturday, October 21, from 1 to 4 p.m., with culinary treats from CMC's Culinary Arts program.
We're proud to be an official stop for the Hwy 62 Open Studio Art Tours for all three weekends this October. You can always find the details for each day of the Art Tours here at CMC on our website at www.cmccd.edu/events so come on by!
#coppermountaincollege #joshuatree #hwy62arttours2023 #hwy62arttours #Hwy62 #morongobasin #highdesert #desertlife #yuccavalley #29palms #twentyninepalms #wondervalley #landers #pioneertown #morongovalley #morongo #socal #desertart #dayofthedead #DiadeMuertos2023 #desertliving
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Exotica insecticide cartap hydrochloride 4 + fipronil 0.5 cg
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here is a list of the top 10 insecticides used in India:
Chlorpyrifos: A broad-spectrum insecticide that is used to control a wide range of pests.
Imidacloprid: A systemic insecticide that is used to control sucking insects such as aphids, whiteflies, and thrips.
Fipronil: A broad-spectrum insecticide that is used to control a wide range of pests, including termites, ants, and beetles.
Lambda-cyhalothrin: A synthetic pyrethroid insecticide that is used to control a wide range of pests, including mosquitoes, flies, and cockroaches.
Acetamiprid: A systemic insecticide that is used to control sucking insects such as aphids, whiteflies, and thrips.
Thiamethoxam: A systemic insecticide that is used to control a wide range of pests, including sucking insects and soil-dwelling pests.
Cartap hydrochloride: A systemic insecticide that is used to control a wide range of pests, including rice stem borers and diamondback moths.
Cypermethrin: A synthetic pyrethroid insecticide that is used to control a wide range of pests, including mosquitoes, flies, and cockroaches.
Dimethoate: A systemic insecticide that is used to control a wide range of pests, including aphids, thrips, and spider mites.
Malathion: An organophosphate insecticide that is used to control a wide range of pests, including mosquitoes, flies, and aphids.
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I JUST FINISHED MY PRESENTATION AND SPEAKER NOTES ITS 27 SLIDES AND LIKE 3 PAGES IM EXHAUSTED AND FEEL LIKE COMPLETE SHIT BUT DAMN IT THEYRE DONE AND IM ECSTATIC
#twirling my hair and kicking my feet in the air. does anyone wanna know about the affects of cartap on zebra fish embryos#/j#but also if u have questions I’ve spent like 10 hours on this presentation so bekfbskfn#ok. with that i am going to bed. night night#my post#caps tw
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CAS No : 15263-52-2 | Chemical Name : Cartap hydrochloride | Pharmaffiliates
Buy highly pure Cartap hydrochloride, CAS No : 15263-52-2, Mol.Formula : C7H16ClN3O2S2, Mol.Weight : 273.8, from Pharmaffiliates. Login as registered user for prices, availability and discounts.
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Big Shout Out To @hhvrecords (my man Ronald) for the records! 🙏🏻🙏🏻🙏🏻 #records #vinyl #recordcollection #vinylcollection #vinylporn #vinyladdict #instavinyl #vinyladdict #hhv #eloquent #dennisreal #cartap #djparental #hypnotize #derplusmacher (à France, Lyon) https://www.instagram.com/p/B3pHe-Do4hx/?igshid=16y3doi6g03jl
#records#vinyl#recordcollection#vinylcollection#vinylporn#vinyladdict#instavinyl#hhv#eloquent#dennisreal#cartap#djparental#hypnotize#derplusmacher
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(Southern Vangard) Episode 295 - Southern Vangard Radio
BANG! @southernvangard #radio Ep295! WAAAALCOME to our 2nd post-COVID episode, Vangardians! It really is real, can you believe it? Meeks and Doe back in the lab for their usual shenanigans this week, which includes interviews and world exclusives galore. To start, we have WORLD EXCLUSIVE talk break instrumentals from Boston’s LIGHTFOOT, who has an album dropping June 25 on CHONG WIZARD RECORDS called “TERRA INCOGNITA” - and we also managed to grab a quick interview with him mid-mix to talk about the album and more! We also have TWO WORLD EXCLUSIVES from our Thursday interview session guest this week, the one and only CARTA’P aka THE OBVIOUS WONDER of ADAGIO! He has a new album dropping this week called “IN MY SILENCE,” you can check out snippets of the interview at the end of the mix until the full drops on Thursday. Last but not least, we have a WORLD EXCLUSIVE from JACQUES RETRO, who is dropping a single this week on J. SCIENIDE’S STATIC KING RECORDS! Well don’t just stand there, hit play without delay and put up those little prayer hand emoji’s for that #SmithsonianGrade #TwiceAWeek #WeAreTheGard // southernvangard.com // @southernvangard on #applepodcasts #stitcherradio #soundcloud #mixcloud #youtube // #hiphop #rap #undergroundhiphop #boombap #DJ #mixshow #interview #podcast #ATL #WORLDWIDE #RIPCOMBATJACK
Recorded live June 6, 2021 @ Dirty Blanket Studios, Marietta, GA
southernvangard.com
@southernvangard on #applepodcasts #soundcloud #youtube #spotifypodcast #googlepodcasts #stitcherradio #mixcloud #SmithsonianGrade #TwiceAWeek #WeAreTheGard
twitter/IG: @southernvangard @jondoeatl @cappuccinomeeks
Talk Break Inst. - "Lemon Tree" - Lightfoot ** WORLD EXCLUSIVE **
"CIA" - Carta'P ** WORLD EXCLUSIVE **
"NAGL (Not A Good Look)" - Carta'P ** WORLD EXCLUSIVE **
"River Of Light" - Apathy
"Scammers" - Sons Of Silverton (prod. DJ Rare Groove)
"Calling Me Back" - Verbz & Illinformed
"Sound The Horns" - The Good People
Talk Break Inst. - "Gas Periodos" - Lightfoot ** WORLD EXCLUSIVE **
"Real Late" - Peter Rosenberg ft. Vel the Wonder (prod. DJ Skizz)
"Early Exit" - Lloyd Banks ft. Roc Marci
"Get Hit Up" - Planet Asia ft. SmooVth (prod. Izzynyce)
"Blessings" - David Bars x Mono En Stereo
"Tenements" - Raticus & Miskeen Haleem
Talk Break Inst. - "Incognita" - Lightfoot ** WORLD EXCLUSIVE **
** MID-MIX INTERVIEW - LIGHTFOOT **
Mid-Mix Interview Inst. - "Clean Dopamine" / "Adventures In Sound" - Lightfoot ** WORLD EXCLUSIVE **
"The Fog" - Uptown XO ft. yU & DJ Alizay (prod. Oddisee)
"Inception" - UFO Fev (prod. STER)
"The Commute" - Fatt Father (prod. Foul Mouth)
"Highly Respected" - Illien Rosewell (prod. Eto)
"Kings" Rome Streetz & Ankhlejohn
Talk Break Inst. - "Bottle" - Jacques Retro ** WORLD EXCLUSIVE **
** INTERVIEW SNIPPETS - LIGHTFOOT - FULL INTERVIEW DROPS THURS 6/10 **
SOUNDCLOUD
https://soundcloud.com/southernvangard/episode-295-southern-vangard-radio
APPLE PODCASTS
https://itun.es/us/QyyX9.c/
SPOTIFY PODCASTS
http://bit.ly/svrspotifypodcasts
YOUTUBE
https://youtu.be/0y72WvMHecw
GOOGLE PODCASTS
http://bit.ly/svrgooglepodcasts
MIXCLOUD
https://www.mixcloud.com/southernvangard/episode-295-southern-vangard-radio/
#SouthernVangard #DJJonDoe #EddieMeeks #Lightfoot #CartaP #Apathy #SonsOfSilverton #DJRareGroove #Verbz #Illinformed #TheGoodPeople #PeterRosenberg #VelTheWonder #DJSkizz #LloydBanks #RocMarci #PlanetAsia #SmooVth #Izzynyce #DavidBars #MonoEnStereo #Raticus #MiskeenHaleem #UptownXO #yU #DJAlizay #Oddisee #UFOFev #STER #FattFather #FoulMouth #IllienRosewell #Eto #RomeStreetz #Ankhlejohn #JacquesRetro
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Vehicle Reflective Tape(Magnetic & Non Magnetic)
Self Adhesive Reflective Tape and Strips are used for vehicle identification and industry safety. Also, for the high-impact reflectivity in work. Our reflective Strips and Tapes are best suited for worksite vehicles such as mining, construction, etc. that require high levels of reflection.
Banner House is a leading supplier of Self Adhesive Reflective Tape and Strips across Australia.
We offers Vehicle Signage at affordable prices and supply our products to all major cities including Perth, Melbourne, Sydney, Brisbane, Adelaide, Hobart, Darwin, Canberra and other regional towns.
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carbucketty and tapper need a ship name: cartapity (if you can come up with better ones feel free to list them)
Tap of Bucket
C'mon is right there
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(Southern Vangard) Episode 300 - Southern Vangard Radio
BANG! @southernvangard #radio Ep300! THREE HOURS. ALL WORLD EXCLUSIVES. READ THE TRACKLIST AND WEEP. BIG UP DJ POCKET FOR SLIDING THRU. BIG UP ALL THE ARTISTS WHO BROKE US OFF WITH THAT HEAT. LAST BUT NOT LEAST - YOU’RE WAAAAALCOME #SmithsonianGrade #TwiceAWeek #WeAreTheGard // southernvangard.com // @southernvangard on #applepodcasts #stitcherradio #soundcloud #mixcloud #youtube // #hiphop #rap #undergroundhiphop #boombap #DJ #mixshow #interview #podcast #ATL #WORLDWIDE #RIPCOMBATJACK
Recorded live August 15, 2021 @ Dirty Blanket Studios, Marietta, GA
southernvangard.com
@southernvangard on #applepodcasts #soundcloud #youtube #spotifypodcast #googlepodcasts #stitcherradio #mixcloud #SmithsonianGrade #TwiceAWeek #WeAreTheGard
twitter/IG: @southernvangard @jondoeatl @cappuccinomeeks
** ALL WORLD EXCLUSIVES **
Talk Break Inst. - "Untitled" - D.R.U.G.S. Beats
"Leafs Vs. Flyers" - Lord Juco ft. Vinny Paz (prod. Hobgoblin, cuts DJ Jon Doe]
"'95 Goodie Mob" - OC from NC X Jooselord x B Squared
"Home Goin'" - maticulous ft. Guilty Simpson
"Lesson Of 2 Evils" - Waterr x Vanderslice
"Vespucio Norte" - Ill Conscious x Mute Won ft. DJ Grazzhoppa
"Marathon" - Trillmatic X Conway ft. Benny The Butcher & Flee Lord (prod. Mephux)
"Looka Here" - G4JAG X Give Em Soul
"Avirex" - El Gant ft. Innocent? & King Magnetic (prod. DJ Jon Doe)
"Untitled" - The Quarter Inch Kings ft. Copywrite
"Still of the Night" - Cryptic One
Talk Break Inst. - "Guerilla Zodd" - Ghost Of The Machine
"Homicidal Scene" - Terror Van Poo (prod. Houseman)
"I Don't Wanna Come Down" - Chong Wizard ft. Nolan The Ninja, Nate Barksdale & Sean Rosati
"The Process" - Chris V ft. Yamin Semali
"Joker Joker Deuce" - Señor Kaos & Illastrate
"New Season" - Carta' P (prod. Deffcutz)
"Let it Shine" - Ghost Of The Machine (prod. DJ Proof)
"Last Laugh" - El Da Sensei + Jake Palumbo ft. Wordsworth & Jay Legato
"Simonsen x Hakkedrenge" - Cousin Feo (prod. Machacha)
"What That Iz" - Sir Veterano ft.Flii Stylz
"Highest Science" - Kev Brown & J Scienide ft. DJ Jon Doe
"Untitled" - Joe D ft. yU
Talk Break Inst. - "Drama Chops (Remix)" - J57
"Do Da Wop" - Kaimbr (prod. Judah)
"5 Star Generals" - Body Bag Ben x J Scienide
"Pamela" - L-Biz (prod. Aesthetic)
"I Do This" - Hobgoblin x Sean Links
"Heavy On The Grind" - Spoda & Damn! Dave
"Pato" - Daniel Son x Rankz (prod. JO MILZ)
"Black Dose" - M.A.V. & Asun Eastwood (prod. Sibbs Roc)
"Black Dont Crack" - Rob Viktum ft. 4-Ize
"El Guapo" - Eff Yoo (prod. Tru Cipher)
"Filthy Symphony" - Josiah The Gift
"Champion Pedigree" - Clypto ft. Supreme Cerebral x Eloh Kush & O The Great
"Where's Da Mayo" - Asun Eastwood ft. Smoovth (prod. Wavy Da Ghawd)
"Logo in the Sky" - XP the Marxman ft. Phonk P (prod. GodBlessBeatz)
"Silencer" - Sean Links ft. SyckSyllables x Recognize Ali (prod. Vago)
"Lord Serpentor" - New Villian & Finn
"Power Of A Gun" - Tone Beatz ft. MRK SX & Wizisbeast &G Fam Black
"Mix in the Pot" - Trillmatic X Ruste Juxx (prod. Zealot)
"The Throne" - Mally G ft. Freeway (prod. D.R.U.G.S. Beats)
"Untitled" - G4 Jag & Ransom (prod. Rob Deniro)
"Caviar" - Primo JAB ft Con$piracy (prod. GodBlessBeatz)
"Burnt Sienna" - OCKZ
Talk Break Inst - "Incantation" - Buck Dudley
Talk Break Inst - "Peril - Buck Dudley
Talk Break Inst - "Cold Blooded" - GodBlessBeatz
"Petey Piano" - DOECINO
"Draper Papers" Zilla Rocca & Andrew
"Beyond" - Ace Cannons
"The Return of the Asiatic" - BambuDeAsiatic ft Supastition
"20 Steps" - Napoloeon Da Legend (prod. DUS)
"Patterns" - Vanderslice ft. Planet Asia & Tri State
"The 5th" - Fred Ones ft. Reno rx & Yahzeed
"Ruth Chris" - Mono Slade ft. Johnny Storm (prod. King Rem)
Talk Break Inst. - "Untitled" - D.R.U.G.S. Beats
SOUNDCLOUD
https://soundcloud.com/southernvangard/episode-300-southern-vangard-radio
APPLE PODCASTS
https://itun.es/us/QyyX9.c/
SPOTIFY PODCASTS
http://bit.ly/svrspotifypodcasts
YOUTUBE
https://youtu.be/6IKkRaEMwAk
GOOGLE PODCASTS
http://bit.ly/svrgooglepodcasts
MIXCLOUD
https://www.mixcloud.com/southernvangard/episode-300-southern-vangard-radio/
#SouthernVangard #DJJonDoe #EddieMeeks #DJPocket #DRUGSBeats #LordJuco #VinnyPaz #Hobgoblin #OCfromNC #Jooselord #BSquared #maticulous #GuiltySimpson #Waterr #Vanderslice #IllConscious #MuteWon #DJGrazzhoppa #Trillmatic #Conway #BennyTheButcher #FleeLord #Mephux #G4JAG #GiveEmSoul #ElGant #Innocent #KingMagnetic #TheQuarterInchKings #Copywrite #CrypticOne #GhostOfTheMachine #TerrorVanPoo #Houseman #ChongWizard #NolanTheNinja #NateBarksdale #SeanRosati #ChrisV #YaminSemali #SenorKaos #Illastrate #CartaP #Deffcutz #DJProof #ElDaSensei #JakePalumbo #Wordsworth #JayLegato #CousinFeo #Machacha #SirVeterano #FliiStylz #KevBrown #JScienide #JoeD #YU #J57 #Kaimbr #Judah #BodyBagBen #LBiz #Aesthetic #SeanLinks #Spoda #DamnDave #DanielSon #Rankz #JOMILZ #Mav #AsunEastwood #SibbsRoc #RobViktum #4Ize #EffYoo #TruCipher #JosiahTheGift #Clypto #SupremeCerebral #ElohKush #OTheGreat #Smoovth #WavyDaGhawd #XPtheMarxman #PhonkP #GodBlessBeatz #SyckSyllables #RecognizeAli #Vago #NewVillian #Finn #ToneBeatz #MRKSX #Wizisbeast #GFamBlack #RusteJuxx #Zealot #MallyG #Freeway #Ransom #RobDeniro) #PrimoJAB #Conspiracy #OCKZ #BuckDudley #DOECINO #ZillaRocca #Andrew #AceCannons #BambuDeAsiatic #Supastition #NapoloeonDaLegend #DUS #PlanetAsia #TriState #FredOnes #RenoRx #Yahzeed #MonoSlade #JohnnyStorm #KingRem
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The Importance of Dose-Time-Response Relationships for Hazard Identification and Limitation of Animal Experiments
JUNIPER PUBLISHERS-
Open Access Journal of Toxicology (OAJT)
Author: Henk A Tennekes
Introduction
Historian Heiko Stoff has recently sketched a fascinating controversy in the 1950's on chemical risk assessment [1]. Two renowned scientists in the Farbstoffkommission (Dye Committee) of the Deutsche Forschungsgemeinschaft (DFG, German Research Community), pharmacologist Hermann Druckrey and biochemist (and Nobel Prize winner) Adolf Butenandt, were advocates of a preventive risk approach. This approach was largely determined by a groundbreaking study conducted by Druckrey during the war years with the carcinogenic dye 4-dimethylaminoazobenzene (also known as "butter yellow") [2], and Druckrey's un-intentional cooperation with the electrophysicist Karl Küpfmüller in an American detention camp in Hammelburg, Bavaria [3].
The History of the Druckrey-Küpfmüller Equation
Druckrey demonstrated in 1943 that the carcinogenic action of "butter yellow" was determined by the total dose, and completely independent of the daily dose (Table 1). The product of daily dose D and exposure time (up to liver cancer manifestation) T was always the same:
D. T = constant (1)
and found to be about 1000mg (1 gram) in the case of butter yellow (Table 1).
This dose-effect relationship is known as Haber's rule (or law) [4], named after the German chemist Fritz Haber, who played a key role in chemical warfare in the Great War. Haber's rule originally described the relationship between gas concentration c and time to death t. The smaller the c.t product, the higher the toxicity. Druckrey's observation that Haber's rule also described the dose-response relationship of a carcinogenic substance was remarkable in view of long latency periods. Druckrey concluded from this study that the harmful effects of a carcinogen were cumulative and that thresholds of toxicity for carcinogens do not exist.
Druckrey and Kupfmuller also explained this dose-response relationship theoretically with a mathematical analysis of receptor kinetics, as shown in Table 2 [5]. It was assumed that the carcinogenic effect of butter yellow was due to irreversible interactions with a specific receptor. We now know that the receptor is DNA, and that cancer is the result of cumulative damage to DNA, but that was not known in those years. However, Druckrey and Kupfmuller also postulated that when the effect of receptor binding is irreversible as well, effects would be amplified over time (Table 2). In 1956, when Peter Magee and John Barnes linked the carcinogenicity of dimethylnitrosamine to alkylation of nucleic acids [6], Druckrey took the initiative to investigate the dose-time relationship of diethylnitrosamine (DENA) in rats to verify possible reinforcement of effects by exposure time. After all, irreversible DNA alkylation results in irreversible mutations, and nitrosamines therefore appeared to be perfect model substances. This study confirmed potentiation of carcinogenicity by time [7] which could be expressed as follows:
D. T n = constant (2)
TR is the time constant for the reversibility of receptor binding.
Tr is the time constant for the reversibility of the effect.
C is the concentration of the compound at the site of interaction with the receptor.
CR is the concentration of bound receptors.
E is the effect.
* if C remains constant.
with a value ofthe time exponent n of 2.3. This dose-response relationship is now known as the Druckrey-Kupfmuller equation. The equation explains the harmful effects of low exposure levels of a poison during prolonged exposure (Table 3). The lower the daily dose, the lower the total dose required for the damaging effect, even though the adverse effect occurs only after a long exposure period.
Risk Prevention is Displaced by Risk Management
It is not surprising therefore that Druckrey and his influential friend Butenandt became major advocates of risk prevention. Only substances with a reversible mechanism of action and dose-dependent toxicology (Table 2) were acceptable in their eyes because safe exposure concentrations below a threshold of toxicity could be defined. By contrast, substances with an irreversible mechanism of action which followed equations (1) and (2), had no threshold and exposure should, where possible, be avoided.
However, in the 1960's, this approach was displaced by the ADI (acceptable daily intake) concept, which defines an acceptable level of exposure for a substance, independent of the mechanism of action. The ADI concept was mainly propagated by French professor René Truhaut [8] and received a lot of support from the chemical industry, because it was seen as a manageable concept for product development. This had major consequences for toxicological research. The primary objective of animal experiments was no longer clarification of the dose-response relationship and the mechanism of action, but determination of the dose that did not cause any harmful effect, in comparison to control animals, the so-called No-Observed-Adverse-Effect Level (NOAEL). The NOAEL is then divided by a safety factor, usually 100, to take account of possible differences in sensitivity between experimental animals and humans, and individual variation in sensitivity between humans. That exposure level (NOAEL: 100) is then considered as the ADI, the permissible daily human exposure. An exception was made for substances with mutagenic (DNA-damaging) properties, which were not allowed unless used to treat life-threatening diseases.
The Druckrey-Küpfmüller Equation is Generally Applicable
In 2009, Francisco Sanchez-Bayo showed that the toxicity of the neonicotinoid insecticides imidacloprid and thiacloprid for arthropods was not only dependent on the dose but also on the duration of exposure [9]. Henk Tennekes, who was mentored by Hermann Druckrey in his time at the German Cancer Center in Heidelberg, recognized the dose-response relationships as Druckrey-Küpfmüller equations [10]. The lower the exposure concentration, the lower the total dose required for the damaging effect (Table 4). The subsequent collaboration between Tennekes and Sanchez-Bayo provided additional examples of substances with time-cumulative toxicity (Cartap, Diphacinone, organic mercury) [11,12]. All of these substances cause irreversible receptor binding and irreversible effects, and there are no indications for a threshold [13], so that the ADI for these substances underestimate the actual risks. In any case, it became clear that the theories of Druckrey and Küpfmüller are generally applicable and that equations (1) and (2) are of importance to the risk analysis of chemicals.
The Risks of an Irreversible Mechanism of Action are Underestimated
The widely used neonicotinoid insecticide imidacloprid binds virtually irreversibly to nicotinic acetylcholine receptors in the central nervous system of insects and causes irreparable damage to nerve cells [14,15]. The substance is very slowly decomposed in the soil (half-life 200 days), and may leach into the groundwater, or run-off to surface water [16]. In water, the substance can only be degraded by ultraviolet light (photolysis). In many areas of intensive agriculture, surface water is contaminated with imidacloprid [16]. As a result, nontarget insects are exposed to an extremely toxic substance for a long time, which can lead to massive insect mortality and a break in the food chain [16]. Studies of the Universities of Utrecht and Nijmegen showed that the pollution of surface water with imidacloprid quantitatively correlated with decline of invertebrates and insects-dependent bird species [17,18]. Research in the National Park Dwingelderveld, The Netherlands, and in a nature reserve in Krefeld, Germany, showed that, since the introduction of imidacloprid in the mid-1990's, at least three-quarters of the ground beetles and flying insects have disappeared [16,19]. The risks of imidacloprid have been completely underestimated, with catastrophic consequences for insects and insectivores.
Review of Risk Analysis is Urgently Required
Hermann Druckrey and Adolf Butenandt seem to have defined the correct approach to risk analysis of chemicals in the 1950's, as the new insights of recent years show. The ADI concept of René Truhaut is in any case unacceptable for substances with action mechanisms described by Haber’s rule or the Druckrey- Küpfmüller equation. Dose-response relationships are of much greater importance than a NOAEL in an experimental experiment because irreversible effects can be identified. In addition, dose- response relationships can make accurate estimates of the risks in the real world. This may make risk management more restrictive, but at least a lot safer. And there is another important perspective. Dose-response relationships can make a significant contribution to a strong reduction in the use of laboratory animals (Table 4).
Analysis of Dose: Response Relationships Can Make Many Animal Studies Superfluou
The development of a new pesticide now costs almost $300 million [20], and expenditure for international market authorization procedures have risen exponentially in recent years. This development reflects the increasing concern about harmful effects of pesticides on farmland biodiversity. Imidacloprid is a case in point. The general applicability of the theories of Druckrey and Küpfmüller means that analysis of dose- response relationships can identify and eliminate hazardous substances at an early stage of product development [21]. Dose- response studies can be performed in a short period of time, for example with Daphnia magna (water fleas). In doing so, product development is shifted to substances with dose-dependent toxicology (Table 2). Long-term experimental experiments to determine a NOAEL are no longer necessary, as exposure time has no effect. In combination with a multitude of available in vitro studies (http://www.oecd.org/env/ehs/testing/adopted- testguidelines-toxicity-testing-3r-relevance.htm), this strategy can make a major contribution to the implementation of the 3R Principles (Replacement, Reduction and Refinement) that Russel & Burch first described in 1959 to limit the use of experimental animals [22].
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Để Chậu Đồng Tiền Sai Hoa Cần Chăm Sóc Đúng Cách
Để Chậu Đồng Tiền Sai Hoa Cần Chăm Sóc Đúng Cách
Để có được một chậu hoa đồng tiền đẹp cho hoa nở quanh năm và cây liên tục phát triển ta thường rất mất nhiều công sức chăm bón cho cây,nhưng nếu chăm bón cho cây không đúng cách thì cây sẽ chết và bao nhiêu công sức của bạn đều trở nên vô nghĩa. Với nhiều suối nhỏ dày đặc nơi đây còn lưu trữ được nhiều loài cá quý, ngon, bổ như cá Niêng, cá Trình,cá Phá…ngoài ra trong những năm gần đây huyện còn phát triển nuôi cá Tầm đẻ trứng, cá Hồi…tuy nhiên quy mô còn nhỏ hẹp. Với tổng diện tích trồng nấm là 8.600m2, mỗi ngày, hợp tác xã đưa ra thị trường 150kg nấm chế biến sẵn và hỗ trợ tiêu thụ cho bà con 200-300kg nấm tươi. Dễ dàng nhận thấy, đa số loại cây được chuộng vào dịp Tết có tên gọi khiến người trưng bày cây thêm tin tưởng vào may mắn. Hầu hết các loài hoa đồng tiền có thể thu hoạch khi vòng xoắn nhụy hoa nở rộng. Vào mùa này, hoa bách nhật đang có màu sắc hút hồn” nhất … có ý nghĩa đặc biệt lớn là cầu trường thọ, cầu quốc thái dân an. Với hoa đồng tiền thường 1 tuần thu hoạch 1 lần, ngày trước khi thu hoạch cần tưới đẫm nước cho cây hoa đồng tiên. Nếu lan bị các loại sâu hại thân lá có thể dùng các thuốc chứa hoạt chất Fenitrothion, Trichlorfon như Ofatox 400EC, hoạt chất Cartap như Patox 95SP hay Captafon, Captan hoặc Actara 25WG. Nếu hồ tiêu sung mà không phân hóa mầm hoa được thì việc chuyển hóa sẽ không thành công, cây có thể cho ra bông 2 đợt. Mỗi lần tưới, một điều quan trọng cần chú ý là toàn bộ hệ thống rễ của cây trồng và đất trồng cần phải được tưới đủ nhằm tránh tình trạng đất bị khô, từ đó dẫn tới rễ cây khô.
Trong khi, xử lý GA3 tương tự ở nồng độ 100 và 500 ppm thì làm giảm tổng số hoa và đợt ra hoa rộ đầu trổ trễ hơn 30 - 60 ngày so với đối chứng. Bên cạnh đó các yếu tố vi lượng cũng rất quan trọng cho sức khỏe của cây đặc biệt trong giai đoạn làm bông và nuôi trái. Đặc điểm của giống hoa đồng tiền là kỹ thuật trồng hoa không khó, bên cạnh đó cây sinh trưởng khoẻ, thích nghi tốt với điều kiện tự nhiên. Trồng đồng tiền chậu trồng thích hợp nhất là vụ tháng 3 để thu hoạch vào dịp Tết Nguyên Đán. Vì vậy trông suốt quá trình sinh trưởng, mỗi tháng cần định kỳ ngắt bỏ lá già, hạn chế sinh trưởng quá mạnh làm cho cây chuyển sang giai đoạn sinh trưởng sinh thực được thuận lợi, đồng thời còn làm cho ruộng thông thoáng hơn, ánh sáng đầy đủ hơn và giảm được sâu bệnh. Với khoảng cách này, tơng ứng 5,0 - 5,2 vạn cây/ha (tức là 1.800- 2.000 cây/1sào Bắc Bộ). Toàn cây Đậu rồng đều có thể dùng làm thực phẩm: từ trái đậu non làm rau, hột, rễ củ, lá đến hoa. Nguyên nhân: do nấm Marssonina rosae Lib, thuộc nấm bất toàn, nhiệt độ thích hợp nhất từ 22-26oC, ẩm độ >85%, sống trong đất và lan truyền qua các hoạt động khác của con người. Không còn cách nào khác, phải xịt thuốc diệt côn trùng để hạn chế thiệt hại càng sớm càng tốt.
Đất Tây Nguyên thì quá nhiều mối, nếu có xác bã hữu cơ thì chắc chắn có mối, cứ diệt nó có nghĩa phải dùng thuốc hóa học liên tục, cứ hết hiệu lực thuốc 1 thời gian chắc chắn có lại, vậy vô tình diệt hết các vi sinh vật có lợi khác. Thời vụ trồng: Đa số các giống đồng tiền ưa khí hậu mát mẻ (15 - 250C) nên thích hợp trồng vụ xuân (tháng 3) và vụ thu đông (tháng 9). Chú ý, sau khi cắt xong phải cắm cây hoa vào nước sạch, dấu cắt phải xéo để nước dễ thấm vào thân cây. Làm phiền anh Minh Vịnh một 1 tí nữa là tại sao khi cây dư Lân lại thiếu Kẽm, dư K lại thiếu Mg. Thân ! Giữ nhiệt độ đất 18 - 200C, nếu cao hơn sẽ ảnh hưởng xấu đến việc nảy mầm và cây con sau này phát triển không đều. Đất trồng hoa đồng tiền lý tưởng nhất là loại đất tơi xốp, nhiều mùn, có độ thoáng khí cao, dễ thoát nước. Cần làm giàn che cho tiêu trồng mới, có thể dùng lưới che công nghiệp, lá dừa, phên tre hoặc các vật liệu che chắn nhẹ. Cây hoa đồng tiền dễ trồng, chăm sóc và dễ nhân giống bằng cách tách thân từ khóm cây mẹ. Chọn cây giống nuôi cấy mô có độ đồng đều cao và cây sạch bệnh, tuổi thọ lâu hơn so với cây tách thân.
Nếu khu vực tài lộc của gia đình bạn có nguồn sinh khí phù hợp, khả năng hút tiền tài cũng như giữ chân thần tài của ngôi nhà hoặc công ty, văn phòng.. sẽ được cải thiện đáng kể. 8 mẹo phong thủy hay dưới đây sẽ giúp gia đình, văn phòng của bạn có tiền tài đổ về như nước. Nước tưới giúp cho cây trồng tồn tại và phát triển, nước tưới thấm qua đất trồng, rồi dần dần thấm qua rễ cây trồng bởi quá trình thẩm thấu, sau đấy, nước tưới thấm vào thân cây trồng, thoát dần ra ngoài không khí qua bộ lá của cây. Ít tưới nước hoặc để cây xương rồng khô hạn kéo dài sẽ làm cây teo tóp, không phát triển, sức đề kháng của cây trở nên kém làm cây dễ bị nhiễm bệnh hơn. Vừa qua tôi có nhận được hoa của người thân từ Việt Nam gửi tặng, tôi rất thích bình hoa này, màu sắc thật sang trọng và hoa cũng tươi lâu nữa. Để mua được hạt giống hoa đồng tiền tốt nhất, cho chất lượng hoa đẹp nhất, bạn hãy chọn ở Siêu thị Hạt Giống. Đối với địa lan: Chăm sóc như đối với phong lan, cần chú ý đảm bảo đất nền tơi xốp, nhiều màu ở thể hữu cơ đang hoai mục là tốt nhất. Cháu đã tìm đi nhiều quầy nhưng thị trường hiện nay có quá nhiều loại, cháu sợ mua phải thuốc ko hiệu quả mà có khi còn hại cả cây. Cây có thể nhân giống bằng hạt, bằng củ hoặc bằng cách dâm cành, chúng thường ra hoa rất sớm. Ngắt bỏ lá già: Đồng tiền phát triển rất nhiều lá nếu để nguyên sẽ tiêu hao dinh dưỡng và dễ sinh sâu bệnh hại do vậy muốn có nhiều hoa phải thường xuyên ngắt bỏ những lá già, lá sâu bệnh, thường xuyên vệ sinh đồng ruộng. Hoa đồng tiền khá dễ trồng mà lại có thể trang trí cho ngôi nhà bạn với ý nghĩa hoan hỷ, sự vui vẻ trong gia đình.
Không chỉ làm đẹp bên ngoài ngôi nhà, những bông hoa này còn giúp che dấu những khuyết điểm của hàng rào cũ (bong sơn, gỉ sét, cũ kỹ, thô cứng…. Nha cua Donal Trump: Trong thời gian chờ đợi đặt chân vào Nhà Trắng, gia đình Tân tổng thống Mỹ Donald Trump sống trong căn hộ penthouse đắt tiền ở New York. Hỗn hợp đất gồm 3 phần: tro trấu phải xả nước nhiều lần để giảm độ mặn, đất cát hoặc đất thịt, xơ dừa và phân chuồng ủ hoai. Bệnh đốm lá (Cercospora): Vết bệnh ban đầu là những hình tròn nhỏ hoặc bất định, màu nâu nhạt, nâu đen, nằm dải rác ở phiến lá dọc gân lá, ở mép lá. Bệnh lan từ lá dưới lên lá trên, hại cả cuống hoa và cánh hoa, làm hoa gẫy gục dẫn đến héo. Nhiệt thích hợp khi trồng: Nhiệt độ thích hợp nhất khi trồng cây đồng tiền giống là khoảng 15-25 độ C. Cách đặt bàn thờ nhà chung cư là điều được nhiều gia đình luôn được chú trọng, quan tâm. Mọi ý kiến thắc mắc xin liên hệ với chúng tôi để biết thêm thông tin và giải đáp thắc mắc. Đất phải được cày bừa kỹ, để ải, làm sạch cỏ và xử lý trước khi trồng bằng Carbendazim và Basudin để tiêu diệt các mầm mống sâu bệnh còn tồn tại ở cây trồng vụ trước. Với hoa đồng tiền thì các bạn cần chuẩn bị loại đất tơi xốp, có độ thông thoáng cao, thoát nước, nhiều mùn. Không bón phân cho những cây vừa mới thay đất, thay chậu, nên đợi 3 tháng sau cho cây tái tạo đủ rễ rồi hãy bón phân. Các loài hoa được dịp khoe sắc dưới nắng Xuân, lòng người đi trên phố cũng rạo rực một niềm vui về một năm mới nhiều hanh thông và an lành.
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