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jcmarchi · 9 months

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Researchers improve blood tests’ ability to detect and monitor cancer

New Post has been published on https://thedigitalinsider.com/researchers-improve-blood-tests-ability-to-detect-and-monitor-cancer/

Researchers improve blood tests’ ability to detect and monitor cancer

Tumors constantly shed DNA from dying cells, which briefly circulates in the patient’s bloodstream before it is quickly broken down. Many companies have created blood tests that can pick out this tumor DNA, potentially helping doctors diagnose or monitor cancer or choose a treatment.

The amount of tumor DNA circulating at any given time, however, is extremely small, so it has been challenging to develop tests sensitive enough to pick up that tiny signal. A team of researchers from MIT and the Broad Institute of MIT and Harvard has now come up with a way to significantly boost that signal, by temporarily slowing the clearance of tumor DNA circulating in the bloodstream.

The researchers developed two different types of injectable molecules that they call “priming agents,” which can transiently interfere with the body’s ability to remove circulating tumor DNA from the bloodstream. In a study of mice, they showed that these agents could boost DNA levels enough that the percentage of detectable early-stage lung metastases leapt from less than 10 percent to above 75 percent.

This approach could enable not only earlier diagnosis of cancer, but also more sensitive detection of tumor mutations that could be used to guide treatment. It could also help improve detection of cancer recurrence.

“You can give one of these agents an hour before the blood draw, and it makes things visible that previously wouldn’t have been. The implication is that we should be able to give everybody who’s doing liquid biopsies, for any purpose, more molecules to work with,” says Sangeeta Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and of Electrical Engineering and Computer Science at MIT, and a member of MIT’s Koch Institute for Integrative Cancer Research and the Institute for Medical Engineering and Science.

Bhatia is one of the senior authors of the new study, along with J. Christopher Love, the Raymond A. and Helen E. St. Laurent Professor of Chemical Engineering at MIT and a member of the Koch Institute and the Ragon Institute of MGH, MIT, and Harvard and Viktor Adalsteinsson, director of the Gerstner Center for Cancer Diagnostics at the Broad Institute.

Carmen Martin-Alonso PhD ’23, MIT and Broad Institute postdoc Shervin Tabrizi, and Broad Institute scientist Kan Xiong are the lead authors of the paper, which appears today in Science.

Better biopsies

Liquid biopsies, which enable detection of small quantities of DNA in blood samples, are now used in many cancer patients to identify mutations that could help guide treatment. With greater sensitivity, however, these tests could become useful for far more patients. Most efforts to improve the sensitivity of liquid biopsies have focused on developing new sequencing technologies to use after the blood is drawn.

While brainstorming ways to make liquid biopsies more informative, Bhatia, Love, Adalsteinsson, and their trainees came up with the idea of trying to increase the amount of DNA in a patient’s bloodstream before the sample is taken.

“A tumor is always creating new cell-free DNA, and that’s the signal that we’re attempting to detect in the blood draw. Existing liquid biopsy technologies, however, are limited by the amount of material you collect in the tube of blood,” Love says. “Where this work intercedes is thinking about how to inject something beforehand that would help boost or enhance the amount of signal that is available to collect in the same small sample.”

The body uses two primary strategies to remove circulating DNA from the bloodstream. Enzymes called DNases circulate in the blood and break down DNA that they encounter, while immune cells known as macrophages take up cell-free DNA as blood is filtered through the liver.

The researchers decided to target each of these processes separately. To prevent DNases from breaking down DNA, they designed a monoclonal antibody that binds to circulating DNA and protects it from the enzymes.

“Antibodies are well-established biopharmaceutical modalities, and they’re safe in a number of different disease contexts, including cancer and autoimmune treatments,” Love says. “The idea was, could we use this kind of antibody to help shield the DNA temporarily from degradation by the nucleases that are in circulation? And by doing so, we shift the balance to where the tumor is generating DNA slightly faster than is being degraded, increasing the concentration in a blood draw.”

The other priming agent they developed is a nanoparticle designed to block macrophages from taking up cell-free DNA. These cells have a well-known tendency to eat up synthetic nanoparticles.

“DNA is a biological nanoparticle, and it made sense that immune cells in the liver were probably taking this up just like they do synthetic nanoparticles. And if that were the case, which it turned out to be, then we could use a safe dummy nanoparticle to distract those immune cells and leave the circulating DNA alone so that it could be at a higher concentration,” Bhatia says.

Earlier tumor detection

The researchers tested their priming agents in mice that received transplants of cancer cells that tend to form tumors in the lungs. Two weeks after the cells were transplanted, the researchers showed that these priming agents could boost the amount of circulating tumor DNA recovered in a blood sample by up to 60-fold.

Once the blood sample is taken, it can be run through the same kinds of sequencing tests now used on liquid biopsy samples. These tests can pick out tumor DNA, including specific sequences used to determine the type of tumor and potentially what kinds of treatments would work best.

Early detection of cancer is another promising application for these priming agents. The researchers found that when mice were given the nanoparticle priming agent before blood was drawn, it allowed them to detect circulating tumor DNA in blood of 75 percent of the mice with low cancer burden, while none were detectable without this boost.

“One of the greatest hurdles for cancer liquid biopsy testing has been the scarcity of circulating tumor DNA in a blood sample,” Adalsteinsson says. “It’s thus been encouraging to see the magnitude of the effect we’ve been able to achieve so far and to envision what impact this could have for patients.”

After either of the priming agents are injected, it takes an hour or two for the DNA levels to increase in the bloodstream, and then they return to normal within about 24 hours.

“The ability to get peak activity of these agents within a couple of hours, followed by their rapid clearance, means that someone could go into a doctor’s office, receive an agent like this, and then give their blood for the test itself, all within one visit,” Love says. “This feature bodes well for the potential to translate this concept into clinical use.”

The researchers have launched a company called Amplifyer Bio that plans to further develop the technology, in hopes of advancing to clinical trials.

“A tube of blood is a much more accessible diagnostic than colonoscopy screening or even mammography,” Bhatia says. “Ultimately, if these tools really are predictive, then we should be able to get many more patients into the system who could benefit from cancer interception or better therapy.”

The research was funded by the Koch Institute Support (core) Grant from the National Cancer Institute, the Marble Center for Cancer Nanomedicine, the Gerstner Family Foundation, the Ludwig Center at MIT, the Koch Institute Frontier Research Program via the Casey and Family Foundation, and the Bridge Project, a partnership between the Koch Institute and the Dana-Farber/Harvard Cancer Center.

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ramanimaginganddiagnosticcentre · 1 year

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Raman Imaging and Diagnostic Centre: Your One-Stop Solution for Breast Cancer Screening and Diagnosis

Breast cancer stands as the most prevalent cancer in women across the globe. Following lung cancer, it also ranks as the second most common cause of cancer-related mortality among women. Early detection and treatment are essential for improving the outcome of breast cancer.

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drmayurdalvi · 2 years

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This infographic provides important information about renal cancer, a type of cancer that develops in the cells of the kidneys. It includes details about the symptoms, types, risk factors, diagnosis, treatment, and prevention of renal cancer. Additionally, it highlights the expertise of Dr. Mayur Dalvi, an experienced oncologist who specializes in the treatment of renal cancer.

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woso-dreamzzz · 3 months

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Torn V

Kewis x Child!Reader

Summary: You go to the doctor

Usually, when you go to the doctor, it's because Mom has to have another checkup on her knee.

Lately though, it's because of you.

You go to the GP and then you go to another doctor and then another one.

Mom and Mommy are worried about you but you don't know why. They speak in hushed tones together and always make sure to squeeze you extra tight during bed time cuddles.

You don't understand what's going on, even as you're taken to the special doctor and have sticky things stuck to your head.

Mommy says that it's to check you're healthy. You don't know why you have to be checked like this all of a sudden but it's not too bad.

Mom had surgery before. That's scary.

Having weird things stuck to your head isn't scary, not really so you force yourself to be brave.

You get to hold your favourite dino toy nice and tight as you look up at flashing lights and the nurses set you up for the rest of your tests.

Things are weird but you must be brave like how Mommy was brave to move across the world to be with Mom and how Mom was brave when she had her knee surgery.

You have to be brave because Mom and Mommy are brave all the time and you don't want them to see you scared.

You go for more appointments too, to get your blood drawn and to be checked over.

Then, it's a round of waiting.

Mom and Mommy don't tell you what's going on, not really, but they hold you more often.

You're sitting in the doctor's office again when your moms get told the results.

Kristie's been anxious all morning, knee bouncing as the doctor pulls up your file.

Any number of things could be wrong with you.

She'd doom scrolled through google last night, reading about cancer and tumours for so long that Sam had to take her phone from her and hold her as she cried.

You'd never been sick like this before. Sure, you'd had the flu and a tummy bug before but your random zone outs are nothing like that.

Kristie doesn't know how long you've been having them, doesn't know how long they've been ignored for. She doesn't know if they're going to get worse or if you've already hit the worst of them.

She takes Sam's hand tightly in her own, eyes darting down to the floor where you're amusing yourself playing with your dinosaur toys.

"Alright and this is for the little one, right?"

Kristie nods.

"Can you confirm her name?"

"y/n Mewis-Kerr."

"And birthdate?"

Kristie answers easily and squeezes Sam's hand.

"Right." The doctor types in a few more things before swinging his chair around to face them.

"Is she okay?"

"That depends on what your idea of okay is. We can make a diagnosis after seeing the results of her tests."

"And?" Sam asks, getting a bit impatient with this man trying to delay telling them.

He reaches across the desk to grab a pamphlet, offering it up to them.

"We're very confident that Miss y/n has CAE. Childhood Absence Epilepsy."

"Epilepsy," Sam repeats," She's been having seizures?"

The doctor nods. "Now, there's not much to worry about at this stage." He opens the leaflet and points to a section. "The type of seizure she's been having are absence seizures. These are normal enough and aren't as dangerous as others."

"So...So she'll be okay?"

The doctor purses his lips. "Most kids grow out of it by the time they're teenagers but..."

Kristie sighs. "Some don't."

"There is a chance that she'll develop a different type of epilepsy as she grows up."

"That's it?" Sam scoffs, something unfamiliar swelling in her chest. "Oh, your kid has epilepsy! Here you go?!"

"Sam!" Kristie hisses.

"Mom?"

The room falls silent as you twist around to look at Sam, broken out of your play by her loud voice.

"Are you okay?"

Sam looks at you, mouth hung open for a moment before she opens her arms up for you.

You go to her willingly, letting her lift you up onto her lap.

"We're talking to the doctor about you, chook," Kristie says," He's going to help you get better."

"But I'm not sick," You tell her," Am I sick, Mommy?"

Kristie shakes her head. "No, chook and we're going to keep you that way. Let's just listen to what the doctor has to say."

The doctor clears his throat. "From what I've seen and what you've told me, I'm going to recommend some medicine to keep her seizures under control. I'll send off the prescription in a moment and the pharmacy will call you when it's ready. All the dosages and instructions are on the bottle."

Kristie nods as Sam holds you tighter than before.

"We'll schedule another appointment in a month so we can check how she's doing on her new medication and we'll adjust as needed. She'll also need to be seen by her neurologist at least once a year just to check on how she's doing."

"And...And if she does develop a different type of epilepsy?" Sam asks tentatively.

"Then we'll cross that bridge when we come to it."

#woso x reader #kewis x reader #sam kerr x reader #sam kerr #kristie mewis x reader #kristie mewis #woso community #woso imagine #woso fanfics #woso

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dilemmaontwolegs · 10 months

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The Bucket List || CL16

Pairing: Charles Leclerc x fem!reader Summary: Life changes in the blink of an eye with a diagnosis and you are forced to face your mortality with the help of Charles Warnings: 18+ only, nsfw, implied smut, grief, implied character death.

WC: 5.8k

Story || Death Scene || Two Years Later || Bucket Moments || Five Years Later

The winter break was meant to be a time for Charles to relax but one simple act had put an end to those plans. It had been a little joke between lovers while you were getting dressed. Charles had seen an opportunity and taken it, cradling the swell of your breast in his palm and giving it a quick squeeze.

“Honk, honk!”

You gasped at the sudden pain that flared and rubbed at the aching area. Charles was immediately sorry, apologising profusely as he brushed your hand aside and massaged it gently for you.

“It’s ok, Cha, this one’s been a bit tender lately.”

“What do you mean?” His concern was palpable and his hand flattened so the palm was pressing into your flesh. You couldn’t hide the wince at the spot he touched and he couldn’t hide the fear in his eyes.

“What?!” You stepped away and grabbed your breast, almost immediately feeling what he felt as your heart began to hammer hard in your chest. “It’s probably nothing, boobs are lumpy all the time.”

“Yeah…” he murmured distractedly. “We should probably check just to be sure. Right?”

You tried to nod casually but it was too hurried. “I mean, just to be sure.”

Everything moved quickly after that. The exhaustion was no longer jet lag. The low red blood count was no longer anaemia. The lump was no longer just fatty tissue.

“What happens now?”

You looked at your boyfriend, but his eyes were fixed on the doctor who had been explaining the test results. Charles had done all of the talking while you sat in a state of shock. You didn’t even feel like you were inside your own body but floating somewhere in the room and watching from outside.

“We could take a biopsy to be certain but the tests so far are quite conclusive and I wouldn’t recommend waiting. We could fit you in to remove the tumour in the next couple of days and have you home for Christmas.”

You knew this already. He had spoken about removing the lump. You couldn’t bring yourself to call it a tumour because, benign or malignant, it made it too real. Removing the lump was the extreme simplification of what he really meant. Mastectomy. Double to be precise. The risk was too great to leave the other breast untreated, apparently.

“We’ll take the surgery as soon as possible.”

You blinked at Charles, waiting to see if he would even look in your direction before making such a decision but his chin was resting on the tip of his steepled fingers. He leaned forwards, digging his elbows into his knees as he always did when he was deep in thought.

“No,” you rasped. “I can’t do it.”

“Yes, you can,” Charles replied without even looking at you. He had hardly looked your way since the first appointment a week ago.

“I’ll give you two some time to talk,” Doctor Hall said softly as he rose from his chair and left the room, the click of the door closing too loud in the heavy silence.

“It’s my body, Charles,” you whispered, your throat too hoarse to manage anything louder.

“I know that, but this is your life we are talking about.”

“We don’t even know for certain that it’s…that it’s…”

“It’s cancer,” he said with a sigh, “not saying it doesn’t change the test results.”

Your eyes burned, your tear ducts working overtime all week. The harsh lines on Charles’ face softened as he saw them well on your waterline before spilling over. Pulling you into his lap, he cradled your head to his chest as you ruined yet another one of his shirts with your makeup and tears.

“Mon amour, we will get through this but we have to trust the doctors.”

“I won’t have boobs,” you whispered as your voice broke.

Charles curled his finger under your chin and tipped it back as he searched your eyes for the answer. He found what he was looking for and dropped his forehead to yours with a shake of his head. “You will still be the most beautiful woman in the world. And I need you in the world, mon amour, do you understand that? I need you to fight this.”

A few days turned out to be just one after the oncology department received a large, anonymous donation. The private room in the hospital was filled with bouquets from friends and family, their floral scents were almost able to erase the tart smell of bleach. You still felt numb to the entire experience and Charles watched on with concern as you stood in front of the bathroom mirror.

Your reflection was the same, yet it wasn’t. Permanent marker pen lined the skin that would soon be permanently marred. The outlines accentuated what would be taken from you and you turned to your side profile, trying to imagine waking up without the pieces of your body Charles had loved.

“The surgeon said there are options, if it’s really that important to you,” Charles said as he pushed off the doorway he had leaned against and walked into the room. “But you don’t have to think about that now.”

You let him drape the surgical gown over your arms and they fell limp at your side while he tied the bows to keep your modesty. “Come and lay down with me,” he murmured as he took your hand and led you to the bed. You hadn’t been sleeping well, neither of you had.

It was narrow but Charles made space for you to lay in his arms with his chest pressed to your back. Monaco was alive outside the window you faced but the sounds didn’t reach you. Instead of watching the cars on their journeys you turned your eyes up to the cloudless sky and spotted the gulls that danced in the salt air.

“I lo-.”

Charles’ chest shuddered with the breath he took before he kissed your temple and whispered, “Don’t.”

“I need to tell you.”

“We promised, not until you wake up.”

“But what if I-”

“Don’t,” Charles begged, a wet drop falling into your hair. “Please.”

A knock sounded at the door but you kept your eyes firmly only the white feathers of the bird that landed on your windowsill outside. Charles pressed his lips to your temple once more before releasing you from his hold and climbing off the bed.

“I’ll be right there when you wake up, mon amour.”

“I…I’ll see you soon.”

He smiled sadly as you caught yourself from saying what you wanted to say, that sad smile remaining while your bed was wheeled away. You craned your neck as you were taken further down the hall, wanting to memorise the way he looked in case it was the last time you had the chance.

As promised, you woke up bleary eyed and groggy to those gold and green eyes, his hands holding yours tenderly as he sat beside your bed.

“Hi, beautiful,” he greeted as his smile brightened your day. It was a true smile, one you hadn’t seen for over a week, one that crinkled the corners of his eyes and revealed the dimples in his cheeks. “I love you.”

You felt drunk as the anaesthesia still circulated your body and you were sure you slurred the words you had been banned from telling him before. “I love you.”

You dozed in and out of consciousness until the pain relief began to wear off and breathing itself hurt. The bandages across your chest irritated your skin and the stitches pulled with every little movement. Charles noticed it all.

“I’ll see if they can give you anything for the pain.”

You caught his hand before he could leave and winced as the IV line in your hand tugged uncomfortably. “I’m hungry.”

Charles chuckled, knowing you would be after eating nothing before the surgery, and cradled your cheek gently. “Maman’s on her way with your favourites. I’ll be right back, baby.”

Charles arrived back with a large bag of hot dishes from your favourite restaurants around the city and the promise that the nurse would bring some medicine around soon.

“We’ll have someone come and move you up to the ward shortly,” the kind nurse said after she had given you another dose of pain relief. “You’ll be able to see your visitors there.”

You thanked her since you knew your parents would have been waiting with Pascale, Arthur and Lorenzo too. Charles had been keeping them updated since you woke up and his phone was constantly going off with notifications from your friends.

“How are you feeling?”

You placed your fork down into the empty bowl and Charles whisked it off your lap and tidied up the rubbish with the need to keep himself busy. “I don’t know,” you admitted as your head began to clear from the anaesthesia. “Two weeks ago we were partying in Baku and now we’re here. I still don’t know how this even happened. What if they made a mistake? This was all done so quickly.”

Charles carefully tucked the sheet back around your body after helping you to lie back down. “Mon amour, this is one of the best hospitals, they wouldn’t have done this unless it was the right decision for your health.”

“I know, I know. I just don’t know how to feel anything right now, except confusion.” You took his hand as he sat back into the chair beside your bed and kissed his knuckles. “How do you feel?”

“Me?” His brows pinched together as if he hadn’t been thinking for himself, and he really hadn’t. All of his thoughts and feelings had been focused on you. “I’m relieved, I suppose. You are here, I get to kiss you and hold your hand. That is good.”

You smiled at the hope in his voice. “I don’t remember a kiss.”

“Ah,” he hummed with a nod as he leaned closer until his lips were so close you could feel the heat of them as he whispered, “This one.”

You were warned that day two would be the hardest. The hard drugs had worn off and what you were supplied with took away the dull throbbing ache when you were stationary but did nothing to prevent the sharp pain of moving.

Charles had just lifted you back into bed after helping you go to the bathroom when the surgeon arrived with a forlorn look on his face. Immediately you felt the air leave the room.

Doctor Hall started with the good news, that the surgery went as planned with minimal bleeding from the tissue removal, but then there was a pause. Your fingers tightened around Charles hand as the doctor flipped the piece of paper on his clipboard over and clicked the end of his pen.

“When we began the removal of the tumour we found that the shape wasn’t exactly as we expected from the ultrasound.” He drew an oval shape on the paper before adding webs spindling off in all directions and pointing to them. “We removed as many of the tentacles as we could find but they are invasive and so we would like to start chemotherapy as soon as you have recovered from the operation.”

Charles' knee shook the bed as it bounced nervously. “Chemo?”

“Does this mean it is definitely c-cancer?” you stumbled over the word as you said it aloud for the first time.

The doctor nodded. “We were quite sure before but pathology confirmed it with the sample we sent.”

“What about Christmas?” you asked. “Can I still go home for Christmas?”

The doctor nodded again and you exhaled in relief. Christmas had been organised to be held at your house for months and it would give you a chance to do something normal after your life had been thrown off the rails. You needed this Christmas.

“We will schedule you in for after New Years, but you wouldn’t want to delay it much further than that.”

“Thank you,” Charles choked out for the both of you as you fell silent and he left. “What are you thinking so hard about, beautiful?”

“The menu. It needs to be special. And I want to invite everyone.”

“What, slow down, what are you talking about?”

“Christmas, Cha, I need to start planning now.”

Charles knew you were deflecting, pouring yourself into a future task so you didn’t have to think about the present. You had already gone through enough, so he bit his tongue and took a second to clear the thoughts he wanted to voice. Instead, he asked, “who, exactly, is everyone?”

“Slow down, you’re meant to be relaxing,” Charles warned as you rushed around the house for a last minute tidy up. “Don’t hurt yourself, baby, let me help.”

“I love you, but please leave this to me. I know where everything is.”

“I do too,” he exclaimed, falling silent when you picked up a remote that had stopped working. You had asked him to get the batteries for it the night before, but he hadn’t been able to find them.

“Second drawer in the kitchen,” you said as you tossed it to him and folded the blanket you snuggled under with him every night. “But you knew that right.”

He sent you a charming smile as he backed out of the room. “Of course, honey.”

You chuckled at his retreating figure. “Thought so.”

You had just finished lighting the scented candles around the house when the front door opened and Arthur breezed into the living room.

“Merry Christmas, ma chére. Shouldn’t you have your feet up?” he tutted as he kissed your cheeks, careful not to hug you since your chest still hurt.

“Merry Christmas, Tuthur.” His smile lifted at the old nickname and it only grew as you said, “You know how well your brother cooks. Be glad I don’t have my feet up.”

Everyone arrived steadily after Arthur and as the night grew colder every seat in the living room was taken by your guests. You could have imagined it being just like every other family Christmas as you sat on Charles lap and listened to Joris recount how he had spent the winter break so far.

You could have imagined it being just like every other family Christmas, but it wasn’t.

You were self-conscious in a way you never were before. The dresses you had loved so much were now something you couldn’t bear to wear as it accentuated the changes in your body. You had taken one shopping trip with Pascale so you could buy some presents but by the time you had got home there was a photo circulating the F1 WAG pages. The comments had nearly made you sick as they compared your flat chest to that of a young boy, or joked that the championship wasn’t the only thing that was lost at the end of the season.

You knew it was only a matter of time before the truth came out but you doubted they would feel any remorse, anyone who could say such things through a keyboard didn’t have the emotional capacity to feel guilt.

When midnight came and went, so too did the guests. Tipsy and jolly, they said their goodbyes and well wishes until the house fell quiet except for the music playing softly from the speakers. Charles pulled you into his arms and gently rocked you side to side as you laid your head on his chest. “Merry Christmas, mon amour. I didn’t know what to get you this year, so I was absolutely selfish and got this.”

Charles stepped out of your embrace as he dropped to one knee and held a ring out. Similarly designed to his mother’s, the ring was timeless and elegant with a large princess cut diamond. “Will you make me the happiest man and marry me?”

You had waited years for the question but the answer that fell from your lips went against every fibre of your being. Your hands covered your mouth but there was no silencing the words as they hung in the air. “I’m sorry, I can’t.”

Confusion slapped Charles’ pink cheeks and he swallowed twice before his voice could work again. “Why not?”

“You know why,” you whispered.

“No, I don’t.”

“Because I’m sick, and I don’t want to make plans if I’m not going to be there to…I just don’t think now is the right time.” You took the ring from his fingers and sighed with longing. “It’s beautiful, Char.”

“Hold on to it for me,” he said as he stood up and closed your hand around it. “When you beat this, I’ll be waiting, mon amour, however long it takes. I’ll wait for you.”

You held the ring tight as you closed the distance and put all the words and emotion you couldn’t articulate into a kiss, deepening it until you were breathless and needy. “Come to bed,” you breathed against his lips.

“I don’t want to hurt you.” He looked pained by the very idea, or maybe it was the weeks of celibacy after your surgery.

Lacing your fingers together, you took a step towards the stairs and gently tugged him to follow. “You could never hurt me.”

The moment had been weeks in the making as the chemotherapy took its toll on you. For days after the treatment you had been ill and Charles had been at your side with a bowl ready for when you emptied the contents of your stomach. Then your muscles ached and you could barely hold your own weight up to walk. Just when you thought the worst had come to pass you felt the first strands come loose.

“Hello, my dear,” Pascale answered your call, only to be met with a hiccup. “Sweetheart, what’s wrong?”

“M-my hair,” you stammered as you looked at your reflection in the bathroom mirror. Charles had been out shopping but you saw his face appear behind you as you turned to show him what filled your gripped fist. “It’s my hair.”

“I’ll be over shortly, just let me lock up the shop,” Pascale soothed before ending the call.

“I just brushed it,” you hiccuped as you touched your hair again, more of it floating to the tile floor. “It won’t stop.”

“I know, baby,” he murmured as he took your hand and brushed the hair from your palm. “Maman will know what to do. We’ll get through this like we have everything else, together.”

Pascale promised she could have a wig made for you if you wanted one but it was already late in the evening and you knew she was exhausted from working all day. You did however accept her offer to shave the rest of your head so at least the patches of missing hair didn’t stand out as much. Charles had sat with you in the bathroom and held your hand the entire time before asking his mother to shave his next.

“No, I love your hair,” you argued as he pulled his shirt over his head to save it from getting covered in the short dark strands.

“I told you we are doing this together,” he replied as he kissed your knuckles and nodded to his mum to proceed.

It took a while to get used to the smooth feel of skin on your head but you came to prefer it to the wig that Pascale crafted, somehow finding hair that was almost the exact same shade and texture to your natural hair. The moment you got home from any outing you would pull the wig off with a grateful moan just as you used to do with your bra.

“Are you going to be alright? Maman said she can come and stay with you.” Charles sat on his suitcase so he could zip it closed before looking up to where you sat in bed with a book on your lap. “I don’t like leaving you here alone.”

“I’ll be fine,” you reassured him. “It’s only for two nights.”

His team had let him get away with having one extra night at home before going to Bahrain for the 2024 pre-season testing, but it was still too long away from you in his eyes. You would have been with him but you were due some follow up tests.

“You’ll be so busy you won’t even have time to miss me,” you teased, spurring him to climb onto the bed and cage you beneath him.

“I miss you every second we are apart.”

You recognised the number calling your cell phone because you still had nightmares from the last time they rang. A pit of dread was already opening in your gut as you hovered your finger over the green button. You debated not answering the call but if you didn’t answer it then he would try Charles’ number next - and he needed to focus on driving.

You wished you never answered the call.

You had been quiet the entire drive from the airport to the hotel Charles was staying at. He wasn’t one to push you to talk before you were ready but he was certainly worried when he reached across the gearbox and placed his hand on your lap. He spared a glance to you as he gently squeezed your thigh but still you didn’t react, or take his hand, or even blink.

You didn’t remember the walk from the car to the hotel room. You were busy thinking about how you were going to break Charles’ heart, something you had never imagined you would have a hand in. You never wanted to hurt him, you loved him more than life itself, a life that was going to be shorter than you had once thought.

Charles stood quietly in the doorway to the bedroom, your suitcase still in his hand. He watched as you pulled your wig off for the first time since leaving Monaco and listened as you sighed heavily. His feet only carried him closer when you pulled a piece of paper from your pocket and held it out silently.

“What’s this?” Charles asked as he unfolded the note you had written on the plane. You had almost 10 hours to think of everything you wanted to do while you could and his eyes scanned over the list. “Baby, what is this?”

“It’s my bucket list.”

“A bucket list?”

“It’s a list of what I want to do before I die.”

“I know what a bucket list is!” He took a breath and ran his hand over the fuzz that had grown back on his scalp before lowering his voice as he shook the paper. “Why am I holding yours?”

His green eyes blurred with tears as you bit your lip and looked at your feet. He was already shaking his head in denial, wet droplets soaking into the list.

“My results came back…”

“Non, non, baby, non…”

“I’m sorry, Charles,” you choked as he fell to his knees and let the paper fall to the floor. His arms encircled your hips and you cradled the back of his head to your stomach as he cried against you. You finally let your own tears fall, the tears you had held back since you received the news. “I’m so sorry.”

Charles missed testing the next morning as he held you in his arms. The tears had long run out but the sadness still remained. He had laid with you all night as close as your bodies would allow and together you had seen the sunrise over the desert. He had listened to you quietly recount the doctor’s words but most of it made no sense to him.

Metastasized. Stage four. Terminal. The information ruined him.

“How long?” he finally asked. He looked at the paper that was still on the bedroom floor before clearing his throat and trying again. “How long do we have?”

You didn’t know if answering him would help or not but he was waiting for an answer as you rolled over to face him. The last three months had taken a toll on him and dark circles rimmed his eyes and they no longer held the same brightness. They were only going to dim more at the news. “Six months, maybe a year.”

He was silent, but you knew it wasn’t because he hadn’t heard you. Emotions warred behind his eyes before he climbed out of the bed and walked into the bathroom, locking the door behind him.

You hated the silence but the screaming was worse. The painful wail echoed around the room and you felt it shatter something deep in your chest, before something shattered in the bathroom.

Pulling your knees up to your chest, you held yourself together while Charles fell apart.

You weren’t sure how long he screamed at the universe, how many times he asked it why, what he had done to deserve to lose someone else he loved. You weren’t sure how long it took him to clean the blood from his fist and wash his face of the tears before he unlocked the door and slipped back into the bed.

“Whatever you want, mon amour,” he promised as he unclenched your hands and curled his body around yours. “Anything you want to do, we’ll do it. We’ll do it all together.”

You stood at the edge of the lookout and smiled at Charles as he took the photo, another one for the memory box you were making together. Charles kept his promise, taking you everywhere around the world with him to tick off the items on your bucket list.

You had watched him win his home race for the first time and gone to a couples cooking class.

You visited all the Disneyland Theme Parks you hadn’t been to before: the Tokyo one when he raced in Suzuka, the Chinese one when he raced in Shanghai and the Floridian one when he raced in Miami.

Charles had taken you to Iceland to camp under the northern lights and to Pamukkale in Turkey where the blue waters were meant to work miracles. It hadn’t cured the illness that ravaged your body but each activity you crossed off cured some of the sadness in your soul.

“It’s bigger than I imagined,” Charles commented as he looked up at Christ the Redeemer. “What size shoes do you think he wears?”

“Well you know what they say about big feet.”

Charles’ head fell back with a laugh. “You cannot say that about Jesus.”

You fluttered your eyelashes innocently as he stepped closer to take a photo of you together. “I was going to say he wears big socks, get your head out of the gutter.”

“Of course you were, mon amour.” Charles’ lips curled up in amusement and you relished the way his eyes crinkled before you rose onto your toes so you could kiss him before the smile faded.

The flash of his camera captured the moment and you reluctantly pulled away as the sun began to set on another day spent living. The days were getting tiresome, your energy flagging as the medication changed from treating the illness to managing the pain. You had read enough to know that time was running out.

“We should get going, don’t want to miss our flight to Vegas.”

“About that…” he trailed off as he pulled a piece of paper from his pocket and placed it in your hand. “I made a list of my own.”

Marry the woman of my dreams.

“I can only do it with you by my side.”

—

Pascale had created a beautiful headpiece for your wedding but when it came time to leave you hadn’t been able to place it on your head. A year ago you had only dreamt of the day you married Charles and in all those imagined scenes you had your hair styled up like she had crafted on the wig with pearl pins and a delicate tiara. But a lot had changed in a year, you had changed.

“Oh, sweetheart, you look beautiful,” she said as she wiped her eyes. Your own mother was speechless as she pulled you into her arms and held you tight.

“I’m going to ruin my makeup if you two don’t stop crying.”

“Honey, let her go,” your dad said softly as he placed a hand on your mother’s shoulder. “It’s time.”

Your throat felt as if it were closing and for a second you held on tighter before you both opened your arms. “I love you,” you said to them all as you looked at the proud but sad smiles on their faces. “Thank you for making this possible, for both of us.”

Your father grabbed the wheelchair you had been using, the exhaustion sometimes too much for you to handle, but you shook your head. “I’m going to marry him on my own two feet.”

You knew Charles had a lot of help organising the wedding because there was no way he could have done it on his own. The entire paddock had come to a standstill at the end of Media Day and you found yourself walking down a makeshift aisle on the grid to the starting lights.

Hundreds of friends joined your families on the track and you had no doubt that Charles had flown them all there at his own expense.

“When you said married in Vegas, I thought you meant the White Chapel,” you whispered with a giggle.

Charles' smile grew at the sound and he took your hands in his. “That’s something tacky Pierre would do.”

“Hey,” the groomsman objected beside Charles. “Elvis isn’t tacky. Focus on your own wedding, mate.”

You laughed at the exchange before Lorenzo cleared his throat and your eyes widened as you realised he was the celebrant. “Is this legal?”

“The online certificate I got says so,” he said with a wink. “But if you’ve changed your mind I can skip the legal bits.”

Your eyes lit up with amusement. “No way, I’m not going to miss having you as a brother-in-law.”

“And I thought we were here because you wanted to marry me,” Charles joked. He had waited so long to marry you but now that the moment was here he was in no rush for it to end. He wanted to stay in this moment forever, where you were lighthearted and smiling. Where you weren’t lost in thought but present in the moment, with him.

“I do,” you said with a grin before peeking back at his older brother. “Does that count, can I kiss him now?”

Lorenzo wrinkled his nose and shook his head. “I’m afraid it’s not quite, shall we get started?”

Charles could hardly keep still with his excitement. “Ready, baby?”

You reached into a hidden pocket in the dress and pulled out the engagement ring he proposed at Christmas with. Slipping it into your finger, you gave him a serious nod. “Now I am.”

—

“Good morning, Mrs Leclerc.”

You smiled as Charles kissed your shoulder blade and rolled you over to face him. He had already showered and dressed for the day before climbing back into bed with you and you peeked at the clock to see he would almost be late.

“You should be at the track already,” you hummed between the sweet kisses he peppered across your skin.

“Wasn’t going to miss watching you wake up as my beautiful wife for the first time.” His smile wavered as he kissed your forehead before pressing the back of his hand to it. “How are you feeling?”

“A little tired, but last night was worth the lack of sleep.”

He smirked and traced your lips longingly with his eyes. “Definitely worth it. But you don’t feel hot or cold?”

“Focus on FP1, Cha,” you said with a little push for him to get out of bed. “You’re going to be late.”

He playfully nipped your collarbone before getting off the bed and blowing you a kiss. “Rest up, mon amour, I’ll come back between the practices.”

“I love you.”

“I love you too, more than the moon and the stars.”

“Hopeless romantic.”

“Love of my life. Fire in my loins. The apple of my-“

“Go away!” You tossed a pillow at him before falling back into the warm blankets with a laugh that turned to a yawn. “Profess your love to someone else and let me sleep.”

“Never,” he chuckled quietly as he watched your chest rise and fall into a steady rhythm. “It will only be you.”

Your health deteriorated rapidly after Vegas and your doctor urged you to return to Monaco, but you weren’t ready to leave just yet. There was only one thing left on your bucket list and it was within your grasp. Charles and Max were neck and neck in the championship but you had faith your husband would triumph in the end. So instead of heading home you remained by his side in Qatar and Abu Dhabi, letting him hire a medical team as a trade off for ignoring your doctor's advice.

It wasn’t just the season coming to an end and you could both feel it as Charles prepared for the final race. You didn’t have the strength to go to the track and see him start from pole, the prime position for the championship deciding race. You barely had the strength to stay awake for the whole race but you fought against the heaviness in your body and scanned the screens that had been brought into your room.

Pride made you heart light as you watched the world through Charles’ eyes. The onboard camera was clear ahead, all his competitors in his rear view, and as the laps passed by his lead grew wider. Charles was flying and he was taking you with him.

Charles took a seat on the centre podium as confetti rained down and fireworks exploded overhead. He wiped the sweat and champagne from his face before reaching into his race suit and grabbing the pen and paper he had tucked away.

Putting a strike through the last line he held it up triumphantly to the camera. “We did it, mon amour, we did it.”

You smiled as if he would see it and closed your eyes as you lost the battle. “I’m ready to go home now.”

The Bucket List:

Sleep under the northern lights

Swim with sharks

Skinny dip (not with sharks)

See Christ the Redeemer

Bowl a strike

Go to every Disneyland once

Ride an elephant

Go to India for the colour festival

Win an escape room

Learn to whistle

Have a mud bath

Teach Charles to cook

Watch the Grand National horse race

Get a tattoo

Learn to use chopsticks

Throw beads at Mardi Gras

Have my palm read

Try absinthe

Ride a luge

Go to a rage room

Join the mile high club

Catch a fish

Make a will

Bathe in healing waters

Charles Leclerc - World Champion

Click here for the requested last day alive.

#charles leclerc fanfic #charles leclerc imagine #charles leclerc x reader #charles leclerc x you #tw: cancer #f1 imagine #f1 fanfic #formula one imagine #formula 1 fanfic #formula one fanfiction #f1 rpf

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mindblowingscience · 21 days

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The average glioblastoma patient survives 12-18 months after diagnosis. The crux of the diagnostic is a biochip that uses electrokinetic technology to detect biomarkers, or active Epidermal Growth Factor Receptors (EGFRs), which are overexpressed in certain cancers such as glioblastoma and found in extracellular vesicles. “Extracellular vesicles or exosomes are unique nanoparticles secreted by cells. They are big—10 to 50 times bigger than a molecule—and they have a weak charge. Our technology was specifically designed for these nanoparticles, using their features to our advantage,” says Hsueh-Chia Chang, a professor of chemical and biomolecular engineering at the University of Notre Dame and lead author of the study about the diagnostic published in Communications Biology.

#Science #Health #Biology #Biomolecular Engineering #Blood Test #Cancer #Brain Cancer #Glioblastoma

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medidectindia · 1 year

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Advances in Cancer Detection: Promising Tests for Blood, Breast, and Lung Cancer

Cancer is a formidable disease that affects millions of lives worldwide. Early detection plays a pivotal role in improving treatment outcomes and survival rates. In recent years, significant progress has been made in developing tests for the detection of various types of cancer. In this article, we will delve into the latest advancements in cancer detection, focusing on tests for blood cancer, breast cancer, and lung cancer.

Blood Cancer Detection:

Blood cancers, also known as hematologic malignancies, include leukemia, lymphoma, and myeloma. Detecting these cancers early can greatly impact treatment decisions and patient outcomes. Recent breakthroughs have led to the development of innovative tests that aid in the detection and monitoring of blood cancers.

One such test is the liquid biopsy, which analyzes small fragments of circulating tumor DNA (ctDNA) found in the bloodstream. Liquid biopsies provide a non-invasive alternative to traditional tissue biopsies and can detect specific genetic mutations or chromosomal abnormalities associated with blood cancers. These tests enable oncologists to assess disease progression, monitor treatment response, and identify the emergence of resistance to targeted therapies.

Another valuable diagnostic tool for blood cancer detection is flow cytometry. This technique analyzes the physical and chemical characteristics of individual cells in a blood sample. By identifying abnormal cell populations, flow cytometry helps in diagnosing and classifying different types of blood cancers. It provides valuable information on the presence of specific cell markers, enabling precise characterization of the disease.

Furthermore, advanced imaging technologies, such as positron emission tomography-computed tomography (PET-CT), contribute to the detection and staging of blood cancers. By visualizing metabolic activity and anatomical changes, PET-CT scans aid in identifying affected lymph nodes, organs, and bone marrow involvement.

Test to Detect Breast Cancer:

Breast cancer is one of the most prevalent cancers in women globally. Timely detection is crucial for effective treatment and improved survival rates. In addition to regular mammograms and clinical breast examinations, several innovative tests have emerged to enhance breast cancer detection.

One such test is molecular breast imaging (MBI), also known as breast-specific gamma imaging (BSGI). MBI uses a small amount of radioactive material to create detailed images of breast tissue. It is particularly effective in evaluating women with dense breast tissue, where traditional mammograms may yield limited results. MBI can identify suspicious areas that may be missed by mammography, thereby aiding in the early detection of breast cancer.

Another promising approach is the development of blood-based biomarker tests for breast cancer. Researchers are investigating various circulating biomarkers, such as circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA). These biomarkers can provide valuable information about the presence and characteristics of breast cancer, potentially serving as non-invasive tools for early detection and monitoring of the disease.

Additionally, advancements in genetic testing have led to the discovery of specific gene mutations associated with breast cancer susceptibility, such as BRCA1 and BRCA2. Genetic testing enables individuals with a family history of breast cancer to assess their risk and make informed decisions about preventive measures, including enhanced screening and risk-reducing surgeries.

Test to Detect Lung Cancer:

Lung cancer remains a leading cause of cancer-related deaths worldwide. Early detection is challenging, as symptoms often appear in advanced stages. However, advancements in screening techniques and diagnostic tests have shown promising results in improving lung cancer detection.

Low-dose computed tomography (LDCT) has emerged as an effective screening tool for individuals at high risk of developing lung cancer, such as long-term smokers. LDCT scans provide detailed images of the lungs, allowing for the detection of small nodules or abnormalities. Early detection through LDCT screening enables timely intervention and potentially curative treatments.

Another breakthrough in lung cancer detection is the development of blood-based tests, specifically liquid biopsies. These tests analyze ctDNA and other tumor-associated biomarkers in the blood to detect the presence of lung cancer. Liquid biopsies offer a non-invasive and convenient approach for monitoring disease progression, assessing treatment response, and detecting genetic mutations associated with targeted therapies.

Moreover, researchers are exploring the potential of breath tests for lung cancer detection. These tests analyze volatile organic compounds (VOCs) present in a person's breath, which can provide valuable information about the presence of lung cancer. VOC profiles specific to lung cancer can potentially serve as diagnostic markers, offering a non-invasive and rapid method for early detection.

Conclusion:

The landscape of cancer detection has been revolutionized by advancements in diagnostic tests. From blood cancer detection to tests for breast and lung cancer, these innovative approaches are transforming early detection and improving patient outcomes. Liquid biopsies, molecular imaging, genetic testing, and breath tests are among the groundbreaking tools enhancing our ability to detect cancer at its earliest stages. With continued research and technological advancements, the future of cancer detection holds great promise in the fight against this devastating disease. Early detection remains our strongest weapon in saving lives and reducing the burden of cancer worldwide.

#cervical cancer #diagnosis of cancer #early cancer detection test #full cancer check #cancer check up #cancer screaning near me #cancer treatment #cancer diagnosis #lung cancer diagnosis #blood cancer detection

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fanaticsnail · 4 months

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Snail Life Update

Previous update here.

We are celebrating small victories today, and with the arrival of a doctor in the mail from some beautiful friends to support me through this scare, I thought I'd put my old bartending background to good use and make something special. Thanks for my Chopper, @feral-artistry. I love him 🥹.

Cocktail: Four Pillars Yuzu Gin, Choya Umeshu, Aperol, fresh mandarine juice, and half an egg white (laid by our Araucana hen, Consuela). Shaken with ice, garnished with mandarine peel and grated dried strawberries (there is also an umeshu plum in the bottom). It is not too sweet, bitter from the Aperol, and sour from the citrus 👌.

Update under here. Likely TMI, and TW for medical talks.

The long and short of it, without being too graphic, is that there is a growth going on in my chest, the left-hand side near where the clot blockage in my armpit is sourced. I have some microcalcification going on, found in the mammogram "panini press" and ultrasound, that is deemed safe for now.

Antibiotics did nothing to shift the clot in my arm, but it is gradually going down and down. The pain is still there, but it's not as intense and unbearable as it initially was. So far, I'm managing. Given how large the vein is raised, everyone was quick to say "cancer" to which, if we're being fair here, is absolutely a possibility with the development of the microcalcifications in my future.

For now, it's being read as benign - so I'm celebrating the victories as they come! I'm at ease with the information, but it's a little unnerving that I have to have it ferment in my chest for another year's time to ensure he was correct in the initial diagnosis.

There is very, very, newfound knowledge that breast cancer is hereditary, and my doctor was very hasty to order a test for me. I am thankful for the care I received from him, he is spectacular. For now, I get to just take paracetamol for the pain, and ibuprofen and aspirin to aid in the flow of blood to ease the pressure (or today, this pretty nice cocktail, if I do say so myself).

This One Piece Community is amazing, and I cherish all of you so, so much. Thank you for letting me share my stories here with you. If you've read this far, know I care so deeply for you, and I hope your day is as happy and bright as mine has been made now. Cheers 🍸.

#life update #glimpses into my life

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consolecadet · 5 months

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Going back to celiac awareness month, though, if you have...

a vague IBS diagnosis from a dismissive doctor

inexplicable chronic diarrhea

and/or mysterious vitamin deficiencies

...get tested for celiac disease! The initial screening, the tTg-IgA (tissue transglutaminase immunoglobulin A) test, is a simple blood test that any primary care doctor should be able to do.

Celiac can develop at any age. People live with celiac symptoms for an average of 6-10 years before getting diagnosed. I know I did, and I was really surprised when I found out I had it. I never noticed a pattern between when I ate foods with gluten in them (which is what triggers celiac symptoms) and when I felt sick...I just felt kinda sick all the time.

Celiac is an autoimmune disease, not a food allergy or intolerance. It can make you really sick, and not just because eating gluten can mess with your stomach. The long-term effects of untreated celiac include bone density loss, severe vitamin deficiencies and malnutrition, and a higher risk of getting certain types of cancer.

Right now, the only treatment for celiac is to avoid gluten (a protein found in wheat, barley, and rye, common ingredients in things like bread, pasta, and beer). It's a pain in the butt, but trust, it's way better than nearly sharting because you ate a croissant.

#boring text posts #medical #celiac tag #celiac

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bleuzombie · 24 days

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Coming this October from @deancashorrorfest …

Artist: @basketcasebetty

Author: @bleuzombie

Title: Survivalism

Rating: Explicit

Summary: Genetic engineers Castiel Novak and Dean Winchester are on the verge of a breakthrough in cancer treatment and possibly even a cure, using genetic manipulation and incredibly, shark DNA.

Following a devastating diagnosis of brain cancer, and amid growing pressure from his boss, Dick Roman, for results, Castiel is pushed to an act of desperation. He tests the cure on himself with disastrous and violent results.

He has never been so hungry.

Major Archive Warnings: Major Character Death, Graphic Depiction of Violence

Tags: Cannibalism, Animal Autopsy, Animal Death, Eating Live Animals, Genetic Manipulation, Blood, Violence, Body Horror, Bad Scientific Practices, Human Experimentation, Physical Assault

A Little Taste:

The smell of the blood, rich and metallic, hits him and Castiel can’t stop the moan that escapes his lips. His stomach growls. He’s just missing burgers. That’s all this is. It can’t be more than that. He clenches his jaw, grinding his teeth, trying to take shallow breaths as he examines the rat before him.

“Specimen 651?” Castiel checks his notes, trying to focus on the task at hand. “Yes, I apologize. This is Dr. Novak performing an autopsy of specimen 651, previously confirmed with Hodgkins stage IV. I have opened the chest cavity, looking for evidence of…” Castiel watches as the blood coats his fingers. He really should be wearing gloves. He’s contaminating… everything. It’s so hard to think. Harder than it should be as he stares at the blood on his fingers. Castiel wants more. He wants more than anything to be covered in the ambrosia cooling around his fingers. Bloody fingertips pull off his mask and before he can think, Castiel picks up the rat, its head goes into his mouth and he bites down.

The taste of the rat is better than any other pleasure he’s known. Castiel shoves the rest of the rat in his mouth, chewing sloppily, trying to ingest it as fast as possible. He feels so hungry.

This October get ready to chow down…

#DeanCas horrorfest #Basketcase Betty #bleuzombie #cannibalism #destiel #supernatural

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decolonize-the-everything · 2 months

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Immediate action is needed to tackle the impact of ethnic and other biases in the use of medical devices, an independent review says. It found pulse oximeter devices could be less accurate for people with darker skin tones, making it harder to spot dangerous falls in oxygen levels. And it warned devices using artificial intelligence (AI) could under-estimate skin cancer in people with darker skin. The review said fairer devices needed to be designed urgently.

In total, it made 18 recommendations for improvement. The government says it fully accepts the report's conclusions. The review was commissioned in 2022 amid mounting concern that ethnic minorities faced greater Covid risks. It looked closely at three types of device where there is potential for "substantial" harm to patients: • optical medical devices such as pulse oximeters, which send light waves through a patient's skin to estimate the level of oxygen in the blood. The light can behave differently depending on skin tone • AI in healthcare • polygenic risk scores, which combine the results of several genetic tests to help estimate an individual's risk of disease and are used mostly for research purposes

Pulse oximeters were used frequently during the Covid pandemic, for example, alongside other observations, to help judge whether a patient needed hospital admission and treatment.[...]

Chest X-rays

One example is the potential under-diagnosis of skin cancers for people with darker skin.

This would probably be a result of machines being 'trained' predominantly on images of lighter skin tones, the team explains. Another concern arises when using AI systems for reading chest x-rays - which are mainly trained on images taken of men, who tend to have larger lung capacities. This could potentially lead to underdiagnosis of heart disease in women, the report suggests, worsening an already long-standing problem.

Call me a fucking extremist but I don't think white people should be building AI and I definitely don't think it should be put in medical devices when the medical industry is already so full of its own systemic bias and especially before there's proper regulations about AI and without more expansive protections for BIPOC in the medical industry.

If you put racist medical device on the market and encourage people to use it knowing it can misdiagnose heart problems and cancer in people with dark skin then they should be able to take you to court for everything youve ever had ¯\_(ツ)_/¯

#ppl defend AI before actual human fucking lives and that perfectly sums up my problem with it actually

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the-ace-with-spades · 3 months

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I'll never write it because it hits a bit too close home for me to write it without mental strain (I'd read it okay tho...) but I have a very specific scenario in my head so—

Bradley gets the same type of cancer his mom died from.

I imagine it's lung or pancreas cancer because I've seen those and they can be quite aggressive or progressive depending on type. In my head, Carole was in her late thirties/early forties at the latest when she got sick and I imagine it was unexpected and quick, as it often is with young cancer.

The thing is, people deal with cancer diagnosis differently in so many ways — some are in complete denial, some try to stay optimistic for their family, and some just... give up.

Bradley's seen enough cancer and death that he can't deny it but he also can't ever believe he has any luck left in life.

He's in his late 20s. He's just been proposed as his squad's candidate for Top Gun. The DADT just got removed. He has a long-term, serious partner (Jake) who he might not be completely open about everything yet but whom he loves and plans to marry and who loves him back. They're planning on buying a house, Jake talks about having kids. Bradley met Jake's family and his life didn't blow up and they even liked him. The years after he stopped talking to Mav were tough, but he's feeling as settled and as happy with his life as he can be at the time.

He goes to his routine physical as normal, maybe his spirometry comes up short or maybe his bloods are a bit off, or maybe he's just feeling more tired than normal and the doc has a feeling.

Doc informs him about the suspicions, he gets the tests done and it turns from suspicion to reality. At no point Bradley mentions it to Jake. He's taken off flying schedule, sure, but he doesn't tell anyone why, just making something up about his eyesight getting worse or maybe about a recurring ear or sinus infection.

Even if the diagnosis wasn't that bad and the oncologist was optimistic prognosis-wise, Bradley, who has already heard the exact same words about his mom's diagnosis, wouldn't believe it at all. Maybe he wouldn't believe it at all to the point that he'd refuse treatment and just let life run its course.

He'd start planning.

Get everything sorted out while he can. Make it as painless for everyone as much as he can.

And it starts small and escalates quickly. He updates his will, he has a med leave meeting with his superiors, advocates for a transfer to an office role.

He breaks up with Jake, still not telling him a thing. Just so he doesn't have to go through it with Bradley as well — because he knows he'd. And you bet he does the break up in a way that pisses Jake off to the point he doesn't realize how suspicious everything is — the timing, the medical leave, Bradley changing from 'let's buy a house together and have kids' to 'i don't think we can really work out together' on the span of weeks. He's brash in the worst way, and obviously, it also makes their friend group wary and isolates him — which was exactly his plan.

There's one person who he knows will be forever guilty if they don't talk. So, you know, he takes a trip down to China Lake and he and Mav talk. He says all the right things he knows Mav wants to hear — that he forgives him, that he's not mad anymore, that he understands, that he still considers Mav his sort of dad and that he was pissed but he's ready to move on. Maybe Mav does the unexpected and explains to Bradley why he pulled the papers and maybe Bradley actually forgives him.

So, you know, with that Bradley is all ready to take on everything alone, never have anyone find out and just start, well, dying on his own, medical partial leave, all of his stuff sold or written into the will, potential transfer to a paper-pushing position in Point Mugu, far away from everyone who could ever care about him, any people who could ever be affected at all by his illness in the blind.

He was not counting on one thing, though — that Mav, forgiven and missing over ten years of Bradley's life, will try to be part of his life again. Calls, visits — Bradley can't really keep it hidden that he's just rolled over his life in the span of weeks, even if he doesn't not why. Bradley was young when his mom got sick but not that young — he remembers how Mav took it, he's not going to retraumatize him.

But it's really hard not to let Mav know too much when he's asking about everything, and he mentions Jake once and Mav runs wild with the information. First starts to prod Bradley, then tries to do his own investigation and finds out that Jake was stationed at the same base and that they had been together before they broke up abruptly not long ago.

He thinks he's connected the dots — Bradley's weird behavior has to be due to heartbreak, y'know — and tries to play a bit of a wingman by approaching Hangman on his own.

The two people Bradley is trying to keep in the blind meet and realize something is fishy. Jake not only gets hit with the face with Bradley's estranged dad existing but also not being estranged anymore and with that Bradley is acting freaking weird. Mav gets hit in the face because it was Bradley who did the breaking up in the nastiest way possible (and he raised him better than that and also can still see he's got the sad lovesick puppy face whenever Mav tries to bring Jake up) but also with the realization that whatever Bradley is doing, he's got them fooled.

In the end, I think it'd be Ice who figures it out (whether or not he and Mav are together in this scenario). Hears all about it from Mav and Jake and has this moment when it all kind of spins in his head, his own experiences and feelings making a callback, and just tells them, it sounds like he's preparing for a goodbye.

Needless to say, Jake is pissed, Mav is pissed. They stage an intervention and you know that Bradley coughs up (probably in some dramatic way as well... like getting sick to the point they call an ambulance for him...). They definitely freak out when they find out he's been refusing treatment this whole time.

(I don't want to go into actual details of treatment but you can bet Mav and Jake are fucking glued to him from then on and they watch him like hawks. It's not all roses and I don't believe it'd be a quick treatment, probably running long, having better and worse days. Maybe he won't even be able to fly afterwards, once he's in remission. Maybe he never goes into remission. I don't know, I don't like thinking that far...)

#tw cancer #bradley rooster bradshaw #jake hangman seresin #pete maverick mitchell #hangster #sereshaw #im sorry there's just a lot of cancer everywhere in my life rn and this is my coping mechanism(ish)#yeah i don't know okay

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