#braf

[evelynmccpetersart]

Brunch with Hank. #sundayswithhank #brunchwithhank #clasicosarasota #brunchwithboxers #boxersofinstagram #dogsofinstagram #BRAF #adoptdontshop #boxerrescueangelsoffl (at Clasico Sarasota) https://www.instagram.com/p/CqQc3V8rv5N/?igshid=NGJjMDIxMWI=

[spilledmilkfkdies]

I love men!! Not all of these but!! Men!!

[ereborne]

Song of the Day: May 28

“Sebona Fi” by Yws Gwynedd

[crttvset]

my mom: why is vintage basquiat at your funeral?

me: thats oomf……

[filaantrocrowdfunding]

Melanoma BRAF Awareness Day: Signs and Treatment

26th May is annually celebrated as Melanoma BRAF Awareness Day. It was started by Melanoma UK, an organization dedicated to raising awareness about Melanoma and supporting patients dealing with it.

According to National Cancer Institute, Melanoma is “Melanoma is a disease in which malignant (cancer) cells form in melanocytes (cells that color the skin).”

Meanwhile BRAF according to Aim at Melanoma Foundation is “a gene that tells your cells how to grow. A BRAF mutation is a change in a BRAF gene. That change in the gene can lead to an alteration in a protein that regulates cell growth which could allow the melanoma to grow more aggressively. Approximately half of the melanomas carry this mutation and are referred to as mutated, or BRAF-positive. Melanomas that do not carry the mutation are referred to as wild-type or BRAF-negative melanomas.”

The primary objective of this day is to increase awareness of Melanoma and its prevention through advocacy, education, and research. Other objectives include supporting conversations between patients and doctors, giving voice to people diagnosed with Melanoma, and empowering patients through information.

Melanoma is one of the most serious types of skin cancer. As per GLOBOCAN 2020, Melanoma is the 32nd most common type of cancer in India and saw 3,916 cases, out of which 2,296 met their demise.

Often, the first signs of melanomas are a change in the size of moles appearing on your body and/or the development of a new pigment or unusual growth on your skin. They can develop anywhere on your body but are usually found in areas exposed to the sun. In people with darker skin tones, Melanomas can be expected to develop in areas like the soles of the feet, the palm of your hands, or fingernail beds, but that is not always the case.

Moles with asymmetrical shapes, irregular borders, uneven distribution of colors, changing diameters, or regularly evolving are often associated with Melanoma. So it is often recommended to consult a doctor when you see a change in any of the moles appearing on your body. Swollen, Itchy, Sore, Rusty, or Bleeding moles are also signs of Melanoma.

If you are facing difficulties in your finances, there are various NGOs you can approach for monetary assistance. Here are some of the NGOs currently operating in India for cancer patients.

Melanoma can be deadly and dangerous. Hence, it is necessary to raise awareness about this disease, especially in India, where there needs to be more awareness when it comes to skin diseases. So, Please share this article with your friends and family. Patients can also start fundraising pages on Child Help Foundation and Filaantro.

Thank you for reading this article and we hope that you have found a new perspective when it comes to skin cancer.

[cncpathlabs]

Avail best offer on Mismatch repair with reflex to braf codon 600 mutation test home collection Near Me from CNC Pathlab at the affordable Mismatch repair with reflex to braf codon 600 mutation test In Delhi, Mismatch repair with reflex to braf codon 600 mutation test Cost Price in Delhi, Mismatch repair with reflex to BRAF Codon 600 mutation lab near me

[theemporium]

all of those moans lando let out on his stream made me think about him being a bratty little braf and so to punish him, you won't let him fuck you, but you let him dry-hump you while he spoons you from behind

and he's just whimpering and panting into your ear, and he's begging you to let him slide inside of you and he's swearing he'll be so good for you. but you don't give in so he iust cums in his pants with the neediest little whine 😭

PLEASE🫠🫠🫠

his face nuzzled into the crook of your neck, lips brushing against your skin as he keeps whining your name mixed with 'please' and 'promise'

and the pathetic wee whimper he lets out when you start grinding your ass against him, listening to the way he cries out when he is all sensitive after he's just came

[becausegoodheroesdeservekidneys]

i'm not a fluent welsh speaker by any means (i went to a second language welsh school where we only got taught our names, hobbies, age, year group, and what we do ok the weekends to recite in the oral exam, which quashed my enthusiasm by a fair bit) but sometimes i find welsh words fitting more to the situation - like, when the weather's sunny but a bit windy, i don't think "oh, it's nice/fine today!", i think "oh, it's braf!" because it feels better. i don't know why, but that's just how it's always clocked to me

Interesting! I mean that makes sense to me, but then I'm both bilingual and synaesthetic

Though actually it's just occurred to me that a shit ton of my Anglo-Welsh friends do the same thing...

[happilyburningwizard]

41 days.

It took 41 days between the new law allowing Swedish police to set up visitation zones before the first one popped up.

In Hageby, a poor part of the town of Norrköping (which is described on Swedish wikipedia as one of the most "immigrant-dense" parts of the municipality), police may now stop and search any person or vehicle, regardless of circumstances. Frida Braf, the local police chief, told Swedish state broadcaster SVT that they will "consider several factors, e.g. police intelligence information, time of day, behaviour and whom the individual is associating with". My translation from here.

The visitation zone will be in place for 2 weeks, the maximum allowance in the new law.

I can't say I'm surprised. By the timing, the background, the history of the place.

This doesn't make Sweden into an authoritarian police state.

But like. When should I worry? How many bricks are in a wall?

Me, I'm lily white and as Swedish as a Maypole. I've never felt like a stranger here. But I've heard the stories my Kurdish and Bosnian friends can tell. I have family who work for the police. They seem okay. But how can I tell from up here on Mt. "Ethnically Swedish"?

Here's hoping I'm making a mountain of a molehill. Hoping the slope is actually quite dry, thank you. But we have issues with race in Sweden, and this isn't the first time I've felt like this.

[charlotte-of-wales]

princeandprincessofwales: Honoured and delighted to be the new Colonel of the Welsh Guards and to join friends, families and loved ones for the #StDavidsDay parade at Combermere Barracks this lunchtime.

Our friends in the 5th Royal Australian Regiment are here too and it was great chatting to them about their role training Ukrainian Armed Forces in the UK.

Wishing a very Happy St David's Day to everyone celebrating today! 🏴󠁧󠁢󠁷󠁬󠁳󠁿

Falch iawn o'r anrhydedd o fod yn Gyrnol newydd y Gwarchodlu Cymreig ac i ymuno à ffrindiau a theuluoedd ar gyfer gorymdaith #StDavidsDay yn Combermere Barracks heddiw.

Mae'n ffrindiau o'r 5th Royal Australian Regiment yma heddiw a braf oedd cael sgwrsio gyda nhw am eu Gwaith yn hyfforddi Lluoedd Arfog Iwcrain yn y DU

Dyma ddymuno Dydd GWyl Dewi Hapus i bawb sy'n dathlu heddiw! 🏴󠁧󠁢󠁷󠁬󠁳󠁿

[llyfrenfys]

Penblwydd Hapus Trelew / Happy Birthday Trelew

137 oed / 137 years old

https://en.m.wikipedia.org/wiki/Trelew

Braf gweld y Gymraeg yn byw ym Mhatagonia - ond peidiwch ag anghofio'r brodorion yn yr Ariannin a gafodd eu dadleoli gan wladychu Ewropeaidd.

It's good to see the Welsh language alive in Patagonia - but don't forget this is only possible due to the displacement of native peoples in Argentina by European colonists.

[kon-igi]

Doc buon pomeriggio, ho fatto ago aspirato per un nodulo alla tiroide

Mi puoi aiutare a capire il referto in modo sintetico?

CAMPIONE INVIATO

tiroide - prelievo agoaspirato ecoguidato nodulo lobo dx

tiroide - esame citologico su agoaspirato ecoguidato

citologia - esame citologico

NOTIZIE CLINICHE:

Nodulo iso-ipoecogeno, a contorni netti, Ø mm 20, del lobo tiroideo dx.

REFERTO

MICROSCOPIA

Il quadro microscopico, moderatamente cellulare, mostra un fondo ematico e numerosi gruppi di macrofagi colloidofagici come da gozzo. Si osservano rari gruppi coesivi di elementi oncocitari con citoplasma granulare ossidilo, nucleolo incostante, talora prominente. Quadro da valutare anche in base ai dati clinici e strumentali, di lesione ossifila categoria indeterminata a minor rischio sec.Siapec*.

Categoria diagnostica: TIR3A (Indeterminate lesion, lower risk) sec. SIAPEC-AIOM-AME-AACE

Italian consensus for the classification and reporting of thyroid cytology. (J Endocrinol Invest Jun;37(6):593-9)

Commento: utile approfondimento con l'analisi dello stato mutazionale dei geni BRAF, NRAS, HRAS e KRAS da eseguirsi su prelievo dedicato*.

*Nota bene: l'analisi citologica e' parte integrante di una valutazione multidisciplinare comprendente l'esame clinico e strumentale (ecografico e/o scintigrafico etc.) ed in caso di discordanza con le altre valutazioni deve essere valutata la prosecuzione dell'iter diagnostico con altre modalità, eventualmente anche di prelievo (Diagn Cytopathol 2000; 22:126-130).

Grazie in anticipo.

(dalle analisi il tsh, ft3 e ft4 nella norma, anticorpi nella norma)

Immagino (anzi, ESIGO) che poi dovrai far vedere tale referto all'endocrinlogo che ti sta seguendo ma lunedì lo manderai via whatsapp anche al tuo medico... non perché ci siano delle cose brutte ma perché è così che funziona.

In parole povere il nodulo su cui è stato fatto l'agoaspirato presenta una CITOLOGIA INDETERMINATA cioè ci sono cellule che fanno il loro lavoro mescolate a cellule che invece potenzialmente potrebbero dare dei problemi.

Si usa l'agettivo INDETERMINATO perché il solo agoaspirato non basta a completare il quadro diagnostico (e infatti viene detto anche nel referto) e sebbene la classificazione TIR3A - Neoformazione follicolare a basso rischio di malignità - indichi un BASSO RISCHIO di tumore, consigliano di approfondire la predisposizione genetica a tale potenziale tumore.

Non è un tumore ma in particolari condizioni potrebbe diventarlo.

Alcuni consigliano l'asportazione con studio approfondito del nodulo (con questo si avrebbe la certezza) ma solo il 20% di questa neoformazioni risultano poi veramente a rischio e l'80% assolutamente innocue.

Sarà il tuo endocrinologo a indirizzarti verso la giusta prosecuzione dell'iter.

[siaradwast]

Welsh Vocab 1 - Geirfa Cymraeg 1

[Plain text: Welsh Vocab 1 - Geirfa Cymraeg 1. End PT.]

Before I start, I would like to specify that all these posts are in a South Wales dialect of Welsh.

The Welsh Alphabet - Y Wyddor Cymraeg

[Plain text: The Welsh Alphabet - Y Wyddor Cymraeg. End PT.]

a, b, c, ch, d, dd, e, f, ff, g, ng, h, i, j, l, ll, m, n, o, p, r, rh, s, t, th, u, w, y

Greetings - Cyfarchion

[Plain text: Greetings - Cyfarchion. End PT.]

Shwmae/Helô - Hello

Bore da - Good morning

Prynhawn da - Good afternoon

Noswaith dda - Good evening

Nos da - Good night

Sut wyt ti? / Sut dych chi? - How are you? (Note - "ti" is the informal & singular you, "chi" is the formal & plural you)

Croeso - Welcome

Hwyl/Hwyl fawr - Goodbye

Pronoun sentence starters

[Plain text: Pronoun sentence starters. End PT.]

Dw i'n - I am

Rwyt ti'n - you are (Informal/singular)

Mae e'n - he is

Mae hi'n - she is

Mae nhw'n - they are

Rydych chi'n - you are (Formal/plural)

Dyn ni'n - we are

(Rydych chi'n can be shortened to dych chi'n, Rwyt ti'n often becomes just ti'n. Dw i'n is technically Rydw i'n but is often shortened)

Days of the week - Dyddiad yr Wythnos

[Plain text: Days of the week - Dyddiad yr Wythnos. End PT.]

Dydd Llun - Monday

Dydd Mawrth - Tuesday

Dydd Mercher - Wednesday

Dydd Iau - Thursday

Dydd Gwener - Friday

Dydd Sadwrn - Saturday

Dydd Sul - Sunday

for nights, "nos" would replace "dydd", so Monday night would be Nos Llun. (This mutates for Gwener - i.e. Nos Wener rather than Nos Gwener)

Months - Mis

[Plain text: Months - Mis. End PT.]

Ionawr - January

Chwefror - February

Mawrth - March

Ebrill - April

Mai - May

Mehefin - June

Gorffenaf - July

Awst - August

Medi - September

Hydref - October

Tachwedd - November

Rhagfyr - December

(Mawrth being March and Dydd Mawrth being Tuesday is I think because Mawrth is also the word for Mars, as in the planet. So the month and the day are named for the planet.)

Other Essentials

[Plain text: Other Essentials. End PT.]

Diolch - Thank you

Plîs / os gwelwch yn dda - Please (Os gwelwch yn dda literally translates to "if you see fit", so it's more of an "if you please" and is a more polite/formal version.)

Diolch yn fawr - Thank you very much (Literally "big thank you")

Esgusodwch fi - Excuse me

Mae'n flin da fi - Sorry (Fully - mae'n flin gyda fi, literally - Sorry is with me, however "flin" on its own does not really translate to sorry)

Weather - Y Tywydd

[Plain text: Weather - Y Tywydd. End PT.]

The weather is feminine so "it is" for weather is usually "mae hi'n", but this can be shortened to "mae'n".

Mae'n.... - It is....

.... bwrw glaw/eira/cesau - .... raining/snowing/hailing

.... heulog - .... sunny

.... braf - .... fine

.... stormus - .... stormy

.... wyntog - .... windy

.... gymylog - .... cloudy (Gymylog is the mutated form of Cymylog - it mutates because mae hi'n is feminine)

.... oer - .... cold

.... boeth - .... hot

Heddiw means today, so "it is sunny today" would be "Mae'n heulog heddiw)

That's all for this post, I'm not listing vocabulary in any particular order, I am quite literally just dumping vocab off the top of my head until the post seems long enough. There are nuances and exceptions that I don't really know how to convey in some circumstances, because to me they seem natural since to some extent as I was raised surrounded by the Welsh language. These posts weren't intended for people to learn Welsh from, but if you're already learning and have other resources for grammar, mutations, pronunciation, etc. these may be helpful. Anyway, unnecessarily long disclaimer over.

[hips-like-battleships]

long story short our vet suspects our dog PJ has bladder cancer and I am not handling it well at all

I picked up the urine sample kit to do a cadet BRAF screen over the weekend and honestly I’d rather stick my hand in a blender than learn my angel girl has cancer

It’s not confirmed yet so I guess I am freaking out prematurely but like. I hate this so much.

[cbirt]

A Bioinformatics Roadmap for Drug Prioritization from Cancer Genomics Data

Cancer is a complicated disease brought on by the interaction of various informational layers. Tumor origin, the appearance of genomic and transcriptomic variations, or interactions with the microenvironment are all factors that contribute to the difficulty of treating tumors. With reference to the types of tumor heterogeneity and the accessible data from next-generation sequencing, the current methods for selecting a therapy are presented in this article. The study elucidates the potential integration of bioinformatics in precision oncology.

Cancer is an evolving dynamic disease that becomes more diverse as the disease progresses. One of the core reasons why medication doesn’t work and patients relapse has been identified as its heterogeneity. A burgeoning area called precision oncology aims to create personalized cancer treatments for every cancer patient using data from epidemiological, clinical, and omics sources. Targeted therapies are considered an anchorage of precision oncology. The Food and Drug Administration (FDA) has authorized 214 predictive biomarkers by the year 2022, up from 39 in 2013, as a result of ongoing attempts to identify novel predictive biomarkers of anticancer drug effectiveness. BRAF V600E inhibitors in melanoma patients and imatinib to target BCR-ABL translocations in chronic myeloid leukemia are common examples of targeted therapies.

Continue Reading

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