#antitumor

[sinophare]

[faultfalha]

A new study has found that inhibition of tumor intrinsic BANF1 activates antitumor immune responses via cGAS-STING and enhances the efficacy of PD-1 blockade. This is a promising development in the fight against cancer.

[lalitrajsingh]

प्रियंगु I Callicarpa_macrophylla I Verbenaceae Analgesic Antipyretic Antitumor Diabetes Leucorrhoea

Safer-Effective-Better-Remedy

#प्रियंगु #Callicarpa_macrophylla #Verbenaceae #Analgesic #Antipyretic #Antitumor #Diabetes #Leucorrhoea #organic #fertilizer #nitrogen #CVDs #inflmmation #gastric_disturbances #hemorrhage #pitta_disorders #phosphorus #skincare #antiaging #antiwrinkle #biomedicine #diabetes #beta-carotene #soap ##healthylifestyle #money #flavonoids #antioxidants #aminoe_acids #proteins #diy #healthylifestyle…

[seasidewanderers]

I have awful chronic bronchitis and N-acetylcysteine is the only thing that works for me, so I have a shit ton of 600mg capsules around. here's the thing. NAC is awesome in general. it doesn't have a lethal dose!

mind you, this is not to say you can just... take a million capsules and be fine. this is to say that if you take one or two more, you'll be okay. at worst, since it's a potent mucolytic, you'll have a cough (that gets worse if you lie down)

if you regularly take paracetamol, KEEP SOME NAC AROUND. even though intravenous NAC is the fastest acting antidote for paracetamol, if you fear you've taken some extra paracetamol, take some NAC and go to the ER.

ingested NAC is not as strong as intravenous, but it could buy you some time, and that's better than nothing.

NAC costs practically nothing, I got a 100 capsules bottle for 25 dollars on Amazon, and it's really the best stuff you can have around just in case you may need it.

PSA:

Acetaminophen/paracetamol has a hard stop upper dose limit, above which it becomes extremely toxic.

That limit is 4g (8 “extra strength” (500mg) tablets) in 24 hours (about 2 tablets every 6 hours).

A single dose of 22 extra strength tablets can kill you.

Taking 12 or more tablets per day for more than a week can also kill you (this is about 3 tablets every 6 hours).

Symptoms of overdose take up to 24 hours to manifest, and are fairly difficult to distinguish from other problems. They include abdominal pain (especially right upper quadrant), nausea, malaise, and confusion.

The antidote (n-acetylcystine) must be given within 8hours of ingestion in order to be useful.

After 10 hours the only thing that will work is a liver transplant.

You might think “why would I ever accidentally take so much?”

Well, acetaminophen is in almost everything in the cold/flu/pain aisle. Migraine combos like Excedrin, cold and flu combos like NyQuil, basically anything that says “non-aspirin pain relief”, and anything that’s branded as a fever reducer. It’s all probably acetaminophen/paracetamol.

So the goal of this post is to get you to read the labels on your medications. Because taking taking Tylenol and NyQuil together for a week (like you might if you had the flu) could kill you.

[omarfor-orchestra]

One thing about me is I will find the structure of the molecule you're talking about. And I will fantasize about it.

[newsepick]

Traditional Chinese medicine shows potential in cancer treatment

Cancer remains a leading cause of death globally, with current treatments often resulting in significant side effects and resistance. Traditional Chinese medicine (TCM), particularly an herbal extract called Huaier, shows promise as an adjunct cancer therapy, boasting multitarget effects and minimal side effects. Huaier’s active polysaccharides have demonstrated antitumor properties, enhancing chemotherapy efficacy and reducing toxicity. While in-vitro and in-vivo studies highlight its potential across various cancer types, further research is required to clarify its mechanisms and validate its safety and efficacy in larger clinical trials.

[aprendendobio]

QUESTÃO ENEM RESOLVIDA: IMUNOLOGIA | VACINA CONTRA O CÂNCER

Resolução da questão ENEM 2022 sobre a utilização de variedade não patogênica de Trypanosoma cruzi como meio de apresentar antígenos tumorais ao sistema imune.

O protozoário Trypanosoma cruzi, causador da doença de Chagas, pode ser a nova arma da medicina contra o câncer. Pesquisadores brasileiros conseguiram criar uma vacina contra a doença usando uma variação do protozoário incapaz de desencadear a patologia (não patogênico). Para isso, realizaram uma modificação genética criando um T. cruzi capaz de produzir também moléculas fabricadas pelas células…

Ver no WordPress

[reality-detective]

Chaga mushroom is a powerful anticancer, antitumor ally. Drink it in tea as a preventative! With all the toxins in our environment, and the cancer rates going up, we could all use some protection! If you know anyone who is battling cancer or has battled it before please share this valuable information.

[timeteaca]

African Treasure: The Story of Rooibos Tea

What do you prefer: tea, coffee? Maybe chicory? Wait, we know – rooibos! Did you guess it? Oh, even if not, TimeTea is sure that you will be interested in reading about where and how this amber-red drink comes from.

So, rooibos (or rooibos) is a herbal tea made from the shoots and leaves of a plant called aspalathus linearis. This specimen belongs to the Legume family and is a shrub up to 1.5 meters in height with small, needle-like leaves.

Aspalathus lineara in its natural form grows exclusively in South Africa – 200 km from Cape Town within the boundaries of the Cederberg mountain range. Today, of course, the plant is cultivated on an industrial scale, but still the plantations do not go beyond the Cederberg Valley. And all for the sake of a pleasant-tasting and energizing drink, which at one time replaced tea for local residents, and then for settlers from Europe.

The first to collect leaves and branches of Aspalatus lineara were the indigenous people – the Hottentot people. Only in the 18th century did the Dutch learn about the plant, and then – closer to the 19th century – the British also caught up. The fact of the “discovery” of rooibos for Europeans is attributed to Carl Peter Thunberg, a Swedish naturalist who was in South Africa on behalf of a Dutch company back in the 1700s. The drink was liked by sophisticated society, and at the beginning of the 20th century they began to export it with might and main. Today, the annual production of rooibos is about 12,000 tons, and half of this is exported.

If you are already tired of coffee and tea or need/want to give up caffeine, rooibos is a great option. It quenches thirst well, tones up, is useful for both adults and children, and can also be drunk without sugar. This herbal tea itself contains a sufficient amount of glucose.

Ready! We’ll dry it and sell it. In addition, rooibos contains enough vitamin C, flavonoids, and a number of minerals. In particular, the flavonoid quercetin has antispasmodic, anti-inflammatory, antioxidant and antitumor properties. Some studies show the effectiveness of rooibos against mutagens, CNS damage and free radicals. Although we, of course, recommend that if something happens, contact doctors, and not tea sellers.

Today you can find this herbal tea in any form: loose, in bags, in pure form and with additives. They even make so-called espresso from rooibos. In general, be sure to try it if you haven’t already!

[triciamfoster]

Essential Oils: Peppermint  Mentha piperita

The following information is from Essential Oils for Beginners: The Guide to Get Started with Essential Oils and Aromatherapy by Althea Press.

DESCRIPTION  Peppermint essential oil is an amazing medicinal with a very strong aroma. It is widely used in a number of commercially produced products, and it makes a fantastic addition to many aromatherapy blends. Peppermint essential oil is derived from the leaves of Mentha piperita. This plant is prolific and easy to cultivate, making peppermint essential oil one of the least expensive on the market. This essential oil has a thin consistency and is typically steam distilled. In aromatherapy, it is used as a top note.  

ORIGIN  Egypt, Hungary, United States  

PROPERTIES  Analgesic, antibacterial, anticarcinogenic, anti-inflammatory, antiparasitic, anti- spasmodic, antitumoral, antiviral, digestive  

APPLICATION  Peppermint essential oil should be diluted 50:50 with a carrier oil prior to use. It is suitable for direct inhalation, diffusion, topical application, and ingestion.  

PRIMARY USES  Soothes aches, pains, and itchy skin, including psoriasis and eczema; eases tension and headaches; soothes respiratory infections and asthma; relieves nausea and other digestive problems; combats viral and fungal infections, including cold Peppermint essential oil provides a wonderful cooling sensation due to the high level of menthol it contains, and when used in a body mist, it provides a fast cooldown. It makes an excellent liniment for relaxing horses ‘muscles, and when horses inhale it prior to a training session, they often focus better. Peppermint essential oil is useful in the creation of nontoxic household products. It is also an aphrodisiac, particularly when diffused. When used in aromatherapy, peppermint essential oil promotes greater mental focus and can help make learning new information easier. It is useful for calming the mind and easing fear. In meditation, this essential oil helps break down resistance concerning new situations; it is also useful for increasing intuitive awareness.

SAFE USE  Conduct a patch test before using peppermint essential oil on your skin. It must be diluted prior to application; blend one part peppermint oil with one part carrier oil before using it in products that will come into contact with your skin. If you get peppermint oil in your eyes or on a cut, expect to feel a severe stinging sensation. Do not apply water, as this will only make the feeling intensify. Flushing the area with a carrier oil will provide relief. Children younger than six years old do not tolerate peppermint essential oil well. Anyone with high blood pressure should avoid contact or ingestion.

[science-lover33]

Decoding the Pharmacological Symphony of Turkey Tail Mushroom: An In-Depth Analysis of its Chemical Composition, Immunomodulatory Mechanisms, and Implications in Cancer Therapeutics 🍄🔬

Salutations, esteemed Tumblr intellectuals! Brace yourselves for a cerebral sojourn into the pharmacological labyrinth of Turkey Tail Mushroom, an exploration that transcends the ordinary and delves into the intricate interplay of its chemical constituents, the sophisticated mechanisms of immunomodulation, and the far-reaching implications of its therapeutic potential in the intricate landscape of cancer biology. Prepare your minds for an expedition into the realms of molecular complexity, immune orchestration, and therapeutic promise. Grab your favorite scientific journal, a pen, and perhaps a lab coat, for this journey is not for the faint of intellectual heart. ☕📚

Chemical Symphony: An Elaborate Choreography of Bioactive Compounds:

In the molecular ballet of Turkey Tail, bioactive compounds are the principal dancers, each executing a meticulously choreographed routine. Polysaccharopeptides (PSPs), intricate glycoproteins with immunomodulatory acumen, command attention. Through the fine-tuned modulation of immune responses, these compounds stimulate various facets of the immune system, orchestrating an elaborate dance that amplifies the body's ability to recognize and eliminate neoplastic cells. Concurrently, beta-glucans, linear glucose polymers, contribute to this biochemical ballet by fine-tuning immune cell responses, enhancing the overall antitumor immune surveillance.

Navigating the Anti-Tumor Terrain: A Molecular Expedition:

Our scientific cartography navigates the expansive anti-tumor terrain mapped out by Turkey Tail's polysaccharides. The inhibitory effects on tumor growth and metastasis are akin to molecular fortifications against cancer progression. Through intricate mechanisms involving the activation of natural killer cells, cytotoxic T cells, and macrophages, Turkey Tail emerges as a sentinel, curbing the unchecked proliferation of malignant cells. Additionally, its antioxidative prowess, rooted in compounds like ergosterol peroxide, further shields cellular structures from oxidative stress, a nexus in carcinogenesis.

Immersive References: Nourishment for the Inquisitive Intellect:

1. Stamets, P. (2012). "Turkey Tail: Old Medicine, New Hope." Integrative Medicine: A Clinician's Journal, 11(1), 54–59.

- Stamets' exposé weaves a tapestry connecting ancient medicinal wisdom with contemporary insights, shedding light on Turkey Tail's multifaceted potential.

2. Wasser, S. P. (2011). "Current findings, future trends, and unsolved problems in studies of medicinal mushrooms." Applied Microbiology and Biotechnology, 89(5), 1323–1332.

- Wasser's comprehensive review acts as a meta-analysis, synthesizing the current knowledge landscape of medicinal mushrooms, positioning Turkey Tail within the broader discourse.

3. Sun, J. E., Ao, Z. H., Lu, Z. M., Xu, H. Y., Zhang, X. M., & Dou, W. F. (2002). "Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice." Journal of Ethnopharmacology, 95(2-3), 285–292.

- In the realm of metabolic interactions, this study offers a glimpse into the potential implications of Turkey Tail compounds in managing hyperglycemia and lipid peroxidation.

4. Kidd, P. M. (2000). "The use of mushroom glucans and proteoglycans in cancer treatment." Alternative Medicine Review, 5(1), 4–27.

- Kidd's magnum opus serves as a compendium, dissecting the applications of mushroom-derived compounds in cancer therapeutics, providing a nuanced understanding.

Empowering the Community: A Call for Translational Excellence:

Knowledge is a potent elixir, yet its administration demands finesse. As we unlock the mysteries of Turkey Tail Mushroom, let us champion translational excellence, bridging the realms of bench and bedside. Always, without exception, seek the counsel of healthcare professionals, for personalized insights into the delicate interplay of molecular intricacies. Our collective journey extends beyond unraveling the pharmacological nuances; it's a clarion call to empower our community with the technical acumen to navigate the dynamic expanse of cancer research. 🌐💚

Your musings on this intricately detailed exploration are most welcome!

[magicoldcottage]

Gardenia

Also known as : Zhi Zi, Cape Jasmine

Scientific Name : Fructus Gardenia Jasinoides

Identification : An evergreen shrub with scented flowers and Orange fruit. Originally from the Southeastern provinces of China.

Properties : Abortifacient, Anti-cancer, Anti-hypoxic, Anti-inflammatory, Anit-mutagenic, Anti-oxidant, Anti-periodic, Anti-pryetic, Antiseptic, Antispasmodic, Antitumor, relaxant, staunches bleeding

Uses : depression, anxiety, insomnia, bleeding/bruises, cancer, skin cancer, headaches, cystitis, cramps and digestive issues

Try It : 6-12g of dry fruit taken will reduce altitude sickness taken for two day prior to flight.

Warnings : Do not take if suffering from diarrhoea, Use nothing but the Fruit.

Parts used: Fruit

Magic : Love, passion, used in poppets to attract others.

Planet : Moon

Element : Water

Deities : Isis, Diana, Morrigan, Luna, Sulis

Folklore and History: Under its original guise Zhi zi it has been a valued medicinal herb for over 2000 years. Within Chinese medicine it is considered a cooling herb. Hence used mainly for issues associated with heat (for example, Fever, Cystitis and irritability).

Plant Tips : Fruit is harvested when it turns a reddish-yellow colour.

For Refences and bibliography please Click here

[tinyshe]

as a disclaimer, not endorsing but sharing interesting reseach

[noisytenant]

how safe are weed vapes compared to like regular vapes? I've recently heard vapes are like horrible for you cus you're just smoking a shit ton of chemicals but does that depends on what's being smoked?....since you said the weed is just being heated up is there less chemical intake overall or just less combustion byproduct like you said before (sorry if this makes like no sense I'm not familiar with this stuff at all or how it works lol but I also had a really bad experience with edibles and have bad lungs so I just wanted to know a bit more)

Hey sorry for responding so late I had gotten most of this post done after you first sent it but I ran out of energy and got too perfectionistic. Anyways here it is:

Excellent question! The first formal modern e-liquid vape was only released in 2003, though various attempts had been made earlier, which means we are still researching the long-term effects they have on health. When the average person says "vape", they almost exclusively mean "e-liquid vape".

Currently, what we can see about e-liquid vapes: They're not very good. They do reduce some smoking risks (no tar) but introduce other risks, and have a reputation of being safer and a potential smoking cessation aid while a reality of unregulated and poorly sourced ingredients which can cause acute and lasting lung damage.

Dry herb vaping, which is what I recommend, is much more straightforward, but only recently popularized and thus still needing more research.

At the risk of being a square: Any time you intentionally inhale something other than air, you're introducing more risk than if you simply never smoked or vaped anything. But like don't let that stop you, we take on risk all the time, that's what harm reduction's all about babey

Dry Vapes are Not Vapes

A vape or e-cigarette is a device that heats and vaporizes a liquid carrier with a suspension of the psychoactive chemical, either nicotine or THC. These are what people think of when they think of vapes, and these are generally the most problematic for having untested and unregulated chemicals while being touted as healthier.

A dry vape/dry herb vaporizer is the method I recommend, which heats the plant material (or concentrate like wax--I haven't done this myself personally) and evaporates the cannabinoids and terpenes without combustion. It's basically like baking your weed in a tiny oven.

This method was popularized most recently in 1993 with Eagle Bill's Shake and Vape, though apparently the principle of boiling vapor has existed since ancient times.

General Smoking Health Risks

Tobacco and weed both produce "tar" when burned--a catch-all for a variety of chemicals, many of which are carcinogenic, produced during combustion. The tar isn't made from the THC or the nicotine, but from the plant matter itself and its additives. If you burn plant matter and inhale the smoke, you inhale a certain number of toxic and carcinogenic chemicals.

There is some conflict on if smoking weed causes cancer. It certainly doesn't carry the same correlation as tobacco, but the reasons are unknown. We don't have long-term studies verifying a connection between the two. Very preliminary lab tests suggest that THC and CBD have antitumor effects, but it'll be a while before we can figure out the deal. There is still risk!!!

Regardless, the deposition of tar in lungs is an irritant and increases risks of things like bronchitis. For someone with asthma or weak lungs, smoking of any kind causes problems.

E-Cigarettes, or e-liquid vapes

E-cigarettes were manufactured to counter tobacco cigs starting in 2003. An e-cig heats a liquid with a suspension of nicotine, atomizing it into droplets of vapor that are then inhaled.

The liquid is usually propylene glycol or glycerol with other additives like flavorants. It seems like propylene glycol and glycerol have been safe for ingestion as a food additive, but being atomized in an inhaled form is pretty new and the effects aren't well-known.

The major issue is that we don't have a standardized and proven-effective vape juice formula. E-liquid is poorly regulated and many samples contain entirely unidentified substances.

This is the major cause for concern.

THC vape liquids have similar issues, including being cut with Vitamin E acetate, which was correlated with a string of vaping-related lung disease, though not fully confirmed to be the culprit.

Hopefully this delineates why vaping, as in e-liquid vaping, is problematic, and why dry vape is comparatively safer.

Why dry herb vape?

The boiling of the material introduces fewer (but not 0) unknown or undesired chemicals into the airstream. You're primarily getting the cannabinoids.

On a user experience level: It's quite weed-efficient, the weed tastes better w/o the smoke, it produces less smell, the vapor is less harsh on the lungs (you can and will still cough if you inhale too much tho), not much less portable than a joint

You can get a bong adapter and get megahigh still (I do have a bong but I don't like getting that fucked up)

Some vapes can heat concentrates, wax, etc. for potent highs (I haven't done this. But you can. Research yourself)

The already vaped bud (AVB) can be saved and reused for edibles, extracts, and concentrates; it's gonna be stripped of a lot of the psychoactives already, but not all of them--obvs be mindful of dosing here

Downsides: You do have to recharge battery vapes and get over the learning curve of batteryless (I'm pretty shit at using mine). You also have to clean your equipment every once in a while which is nbd for me who likes cleaning but yknow it does require upkeep. Easier than cleaning a bong tho

So, could you dry vape tobacco?

You can, but you probably shouldn't. Nicotine itself is highly physically and psychologically addictive and classified as toxic, and while it isn't considered carcinogenic, it is potentially a tumor promoter.

Pretty much everyone I know who's on nic tells me they don't like it, they wish they could quit, and they would never want me or anyone else to start.

Last, some Dry Herb Vaporizer Tips

Controlling the temperature allows you to control which cannabinoids are released to a certain extent.

Hot vapor can still irritate your lungs. Keeping a relatively low temperature (Guides indicate the best range) and having a long enough vapor path that the vapor can cool will help you have a smoother inhale.

Do not use a vaporizer with cheap elements. Plastic near the heating element will cause by-products.

Contaminants and pesticides can be inhaled, source your material appropriately

Overheating can still cause combustion. You will smell, taste, and see smoke if this happens.

All the physical and psychological risks of weed are present--Take it easy, know your limits, don't vape or smoke when you're in an unstable state, etc.

Thanks for reading, I hope this helps you make informed decisions and potentially find a way of intaking weed that suits your needs :) If you have any more Qs I'll try to answer (IN FEWER WORDS)

[tomasorban]

Put a half-teaspoon in each drink, soup, meal... (and 3-5 grams for acute pain)

The beneficial effects of turmeric are traditionally achieved through dietary consumption, even at low levels, over long periods of time. The activities of turmeric include antibacterial, antiviral, anti-inflammatory, antitumor, antioxidant, antiseptic, cardioprotective, hepatoprotective, nephroprotective, radioprotective, and digestive activities. Phytochemical analysis of turmeric has revealed a large number of compounds, including curcumin, volatile oil, and curcuminoids, which have been found to have potent pharmacological properties.

Turmeric is used as an herbal medicine for rheumatoid arthritis, chronic anterior uveitis, conjunctivitis, skin cancer, small pox, chicken pox, wound healing, urinary tract infections, and liver ailments (Dixit, Jain, and Joshi 1988). It is also used for digestive disorders; to reduce flatus, jaundice, menstrual difficulties, and colic; for abdominal pain and distension (Bundy et al. 2004); and for dyspeptic conditions including loss of appetite, postprandial feelings of fullness, and liver and gallbladder complaints. It has anti-inflammatory, choleretic, antimicrobial, and carminative actions (Mills and Bone 2000). The main clinical targets of turmeric are the digestive organs: in the intestine, for treatment of diseases such as familial adenomatous polyposis (Cruz-Correa et al. 2006); in the bowels, for treatment of inflammatory bowel disease (Hanai and Sugimoto 2009); and in the colon, for treatment of colon cancer (Naganuma et al. 2006). For arthritis, dosages of 8–60 g of fresh turmeric root three times daily have been recommended (Fetrow and Avila 1999). For dyspepsia, 1.3–3.0 g of turmeric root is recommended.

full artice: https://www.ncbi.nlm.nih.gov/books/NBK92752/