#antiobiotics

[sexc-snail]

No, wait- one sec, this was a bit but like... Does anyone have any in depth knowledge of this? I know probiotics help gut health and the bacterial ecosystem of the gut, and I know that antibiotics are a.) Differentiated purposes and b.) Are recommended to be taken with probiotics. And antibiotics that do affect the gut bacteria aren't cancelled out by probiotics. Probiotics are microorganisms, antibiotics are medicine (but that doesn't differentiate them as much as you'd think)

But I'm interested in this now. Can someone explain to me how and where they work separately and then how they work together? Antibiotics kill both good and bad bacteria and probiotics bring back the good bacteria but how does it differentiate the 'good' from the 'bad'? Do they work on the exact same area and bacteria types? How do you specialise antibiotics to what bacteria type they should kill (how did we specify antibiotics that help with diahreah and antibiotics that help with viral infections or wounds, etc.)?

Take probiotics and antibiotics at the same time to take a screenshot of my body and see what's wrong with my tummy

[wodania]

finger still hurts… emerg visit was boring af… never trust a chipmunk

[thehollowwriter]

Ya'll have no idea how productive I'd be if I didn't have such a shit immune system istg I'd be top of my grade if i could

[agayconcept]

.

[very-grownup]

What if Dungeons & Dragons was racist?

No, more racist than that.

You’re not thinking racist enough.

Also, what if Gary Gygax wasn’t just a bad person, but an actual convicted criminal who did many crimes?

Now, what if it was more boring, with more unnecessary math, and opinions about toilet paper?

[tafadhali]

On the one hand testing positive for flu made me feel slightly less idiotic about wasting so much time going to the doctor today

On the other hand it’s unclear if I have flu now or had flu when I was last sick a month ago and am just still testing positive… but either way there is absolutely nothing to do about it!

So it’s feeling kind of like a net zero in terms of actionable information

[aqpippin]

aldjakd my boss sent me a performance certificate that says, ‘managed to get through a whole ten hour shift without rolling her eyes or swearing’ 😭

[longhaulerbear]

The goal of this project was to understand the link between gut and lung Pseudomonas colonization in a single patient. By combining clinical and genomic data, we were able to demonstrate that transmission from the gut caused repeated lung colonization.

Whilst it is difficult to generalize the findings of a single case study, these findings support the idea that gut to lung transmission is a major driver of P. aeruginosa respiratory tract colonization in critically ill patients. Lung colonization was associated with the production of cytokines that protect against P. aeruginosa infection, suggesting that a robust host immune response is key to preventing P. aeruginosa lung infection following lung colonization.

Carbapenem antibiotics such as meropenem are key to the treatment of P. aeruginosa infections, and carbapenem-resistant P. aeruginosa has been identified as an important threat by the World Health Organisation and the Centers for Disease Control and Prevention. In this patient, meropenem treatment for a suspected urinary tract infection drove the repeated evolution of resistance, providing a poignant example of the importance of ‘bystander selection’ for AMR39.

Ultimately, selection led to the emergence of a stable population of highly resistant bacteria in the lung, suggesting that the respiratory tract can act as a source of carbapenem resistant Pseudomonas that can transmit to other body sites and potentially to other patients. Migration increases genetic variation, suggesting that within-host transmission may accelerate bacterial adaptation to antibiotics. In this case resistance was driven by local mutation and selection within organs, leading to the emergence of a highly structured pathogen population shaped by a mosaic of selective pressures stemming from antibiotic treatment.

We speculate that the high in vivo mutation rate of Pseudomonas was key to shaping local adaptation to antibiotic selection across tissues, and that within-host transmission is likely to provide a more important source of resistance at smaller spatial scales2, or when mutation rate is low.

Hospital acquired infections caused by epidemically successful MDR and XDR strains of P. aeruginosa have become a serious problem worldwide, and there is an urgent need to develop new antibiotics to treat infections caused by these strains. At the same time, the incredible ability of Pseudomonas to evolve resistance to antibiotic treatment highlights the need to develop novel approaches to prevent or treat Pseudomonas infections. Our study suggests that preventing gut colonization or gut to lung transmission may be an effective strategy for preventing Pseudomonas infection in critically ill patients.

[charlesoberonn]

Fact 1: President is the deadliest job in America, with 17.8% of presidents having died in office

Fact 2: 75% of the presidents who died in office did so before antibiotics were invented

Assumption: If we counted pre-antiobiotics deaths for other jobs, president would no longer be the deadliest job

[barrenclan]

Quesition: What are defiance views on healing and do they have any full time healers in the cult?

I do recall one of the deepling’s mom had some herbal knowledge that helped them heal from their injury.

I don't imagine there's anyone with the particular job of being a healer or doctor, but lots of animals have general knowledge of medicine. I've had a silly idea that some crows will rummage out antiobiotics and tossed meds from human trash in the past, and critters who get into as many fights as Defiance animals do need some kind of wound treatment system.

[were--ralph]

man this sucks i was gonna go to pride but this antiobiotic says i can't be in direct sunlight for long periods and i was going to go to pride for the first time. genuinely sad

[blindbeta]

Hello, I've been looking through all the links in your pinned post, but just to be sure, is it okay if I ask a few questions regarding on 2 of my prominent characters?

1) One of my characters' eyesight had been degrading since they were young, and though they now take special antiobiotics and treatment to prevent further loss of vision, they're only able to perceive shadows, light, and colors (which largely depends on contrast and lighting of the surroundings). Their cane is their main mobility aid in day-to-day life, but when in combat, they use a device similar to the Focus from Horizon: Zero Dawn. Moving targets like enemies or allies are highlighted/outlined with bright colors to indicate where they are, the colors symbolizing who they are. The device is also capable of scanning text or objects and transcribing them in audio form through an earpiece. I've done my best to research how my character's device can be useful for their lifestyle, but not negate or make their blindness an easily bypassed part of their life, but I'd love to hear your thoughts on it.

2) One of my characters has partial blindess caused by a serious injury to the left side of their face. Their injured eye can only perceive some light and shadow, which affects their depth perception quite a bit. Relying on only one eye has caused strain on their uninjured eye, so they have nearsightedness and need glasses to prevent further damage. This character felt more comfortable to write for me because I'm also nearsighted, although to a lesser degree than my character, and my glasses are mostly to protect my eyes from worsening. So far, I've used my own habits and experiences to describe my character's, but since they are partially blind (which they compensate for by memorizing or mapping out their surroundings, training and practice to determine actual distance, and guides (family and close friends)), my own experiences are hardly enough to make my character seem more realistic. I'd like to ask if there are any mistakes I've made with writing them?

For the first one, I suggest adapting already-existing technology, such as the OrCam MyEye or the Sunu Band. OrCam is worn on glasses and is a device that can already detect surroundings and read text. It can also tell you when someone you know is approaching, such as a neighbor whose face the device recognizes. I don’t know how accurate it is, but I find it helpful to acknowledge that some of these gadgets already exist for realism and accuracy. They are not made up devices that might hypothetically help blind people; they are real and usually invented by people in the blind community themselves.

You can explain that you modeled it after the OrCam or it could be a specialized version of it that includes other features. Color coded enemies and teammates also seems plausible considering OrCam’s recognition feature.

Here is a video demonstrating the OrCam My Eye Pro. You can also go to their website here or look them up on YouTube for more videos.

Please note that some of the features can be found elsewhere or replaced with techniques. For example, someone who folds or organizes their money a certain way or uses a money reader probably wouldn’t need the money identification part of the product. Certain people will like certain features more than others, which could also provide characterization.

While this product is not an option for everyone due to the price, it may be accessible in the scenario you described.

You can also avoid negating their blindness by showing how it impacts them in other ways. A few examples may include navigation techniques, lighting preferences, home layout, assistive devices used at home, how they choose to read (audiobooks, trying to find Braille books they like that are actually available), eye strain, sensory issues, stimulation seeking, interactions with the blind community, sports and activities, etc.

Glasses for protection and the other stuff you outlined sounds good to me.

I love that they use a cane during the day, but what about orientation and navigating uneven ground? I ask because the technology you plan to use during combat scenes wouldn’t help with locating uneven ground or steps.

Could they use the cane for navigating in combat?

While on the subject, a Sunu band might also be helpful. It detects objects at and above waist level. However, it is not a replacement for a cane.

As for your second character, eye strain and fatigue are absolutely going to happen as you described. Your character might sometimes cover their injured eye to reduce strain. They may also need more frequent breaks from use of their uninjured eye, such as when reading or doing desk work.

Taking breaks from screens helps. Managing lighting also helps, such as having enough light to avoid strain, although nothing too harsh. For migraines or eye pain, they might carry medication. At home, they can use hot or cold compresses in addition to eye masks to rest their eyes.

So far, what you have described sounds good. Your own experience should be useful in writing this character. However, I also suggest considering how they navigate stairs and uneven ground when walking. Another common obstacle that arises for people with no depth perception is accidentally dropping cups. To circumvent this, it is helpful to use high contrast, avoid glass, and/or intentionally set the cup on the counter before releasing it.

Lastly, I wanted to add that people with partial vision will often be expected or pressured to rely on it. This character might need to self-advocate, as they could still benefit from audio descriptions, screen-readers, and other assistive technology.

If anyone else has ideas, feel free to share in the notes.

Hope this helps.

[hirayaea]

zayne reminds me of this cardiologist I worked with. he was older than me, very confident, pretty good looking and had very niche hobbies. I was his junior and we had a pleasant working relationship.

I was the on call in telemetry (the specialized cardiology ward), and one patient under his care was suffering from an infection. we had brought in the infectious specialist doctor and they prescribed an antibiotic and told me let’s wait and see if any bugs will grow from the blood cultures before we change it.

later that afternoon, the cardiologist comes in and asks me what the infectious specialist said, so I relay the advice that was given.

this cardiologist stares at me and says in very level voice, “no, let’s change the antibiotic, he’s really sick.”

I’m like: “are you sure?”

and he has the gall to smirk and say, “yeah, do you think the infectious doctor will get mad?”

me, in my head: YES!

me, in real life: “maybe?”

anyway he was very cute and maybe I should have fought harder to save both of us but I didn’t

the next day the infectious doctor came back and she was furious, she actually stormed out of the ward

(thankfully not at me, because dr. cardio actually wrote his name first in the sign off so I was saved)

the ending of this story is the cardiologist apologized and said Okay I Won’t Do It Again and the infectious doctor came back

/

anyway the point of this story is I still think zayne would order antiobiotics (specifically very high level ones like meropenem) without telling anyone because he seems like the type and now that I’m older I think I’d fight back ᕦ(ò_óˇ)ᕤ

[iiusia]

phage therapy is SO cool to me. always. it's such a fascinating way of trying to solve the "bacteria are becoming more and more resistant to antiobiotics" problem i am ALWAYS thinking about it.

bacteriophages (viruses that infect bacteria) have two (generally) different types of cycles: lytic and lysogenic. if you wanna use them for phage therapy and killing bacteria then it has (to my knowledge) to have a lytic cycle.

a lytic cycle is when the phage injects its genome into the bacteria, forces the bacteria to replicate it, and then destroys it to release the newly formed phages. a lysogenic cycle is when the genome of the phage gets integrated into the BACTERIA'S dna and stays there for a while before it gets activated and THEN it becomes a lytic cycle.

so if we want to use phages to destroy bacteria, it needs to have a lytic cycle, because if we have an Active Infection going on, we can't really wait for the latency phase of the lysogenic cycle to come to an end. we want the bacteria to die right away.

that's something that's really cool about phage therapy!!! that the "medecine" can just. replicate itself. it's a self-amplifying drug!! every time it kills a bacteria it makes more of itself!!! thats SO cool.

a caveat is that you need to know Which bacteria exactly is causing the sickness so you can select the right phage to kill it. (yeah! usually doctors don't know Exactly Which microorganism is making you sick, unless it's something super specific to One species. usually what is done is prescribing a large-specter antibiotic, which can kill multiple species. this works, but in turn it contributes to the very problem that makes it so we might need widespread phage therapy soon: it very quickly makes bacteria develop a resistance.) but!! we are improving in genome sequencing and it CAN be done pretty fast and inexpensively, now.

[tsuntsunfangirl]

dude, i cannot just keep waffling back to tom hiddleston or whatever character he's currently playing whenever i enter a muse transition period

I REFUSE TO RECOGNIZE THIS

I'M JUST SICK, I'M JUST HORMONAL, JUST A FEW MORE ANTIOBIOTICS AND I'M GONNA BE YOUR NORMAL CAPTAIN PIKE-SCREAMING, SOFT DEMON-WHINING TSUNTSUN AGAIN

@turniptitaness and @izhunny shut up

[andromedasummer]

exercised for the first time in like 3 fuckin months. felt good to get moving but im gonna take my dads advice and wait until ive finished my antiobiotics to do any more. i dont want to undo any progress ive made with my health. ive definitely got work to do to get back to my 30 minute every 3 days regime of 2020-2022 (i barely finished 10 minutes of low impact upper body) but my walk uphill today showed me i havent lost all my progress and that my running/walking endurance isnt going to be as much as a struggle compared to the mountain of making up the muscle mass ive lost