#ano1

[lazyevaluationranch]

*pats askbox gently* there are more Thermoreceptors?

(I'm sorry ur dome was so hot; I hope its much cooler now!)

My bluff has been called! Hooray!!

I am not a neurologist, a biologist, or a scientist. If anyone with better credentials than "obsessed with emergent properties" contradicts me, listen to them instead.

Cell membranes include little portal proteins that open under certain circumstances based on the shape of the protein and let chemicals into and out of the cell. These portals are useful for all sorts of things: managing water and nutrients, sending messages to nearby cells, serving the whims of tiny intercellular cats. Science hasn't found the tiny intercellular cats yet, but we all know they're there; the existence of a door that can be opened necessarily implies an indecisive feline.

Some protein shapes open up if the temperature is within a certain range. This means that if a cell with that sort of protein in its membrane experiences a temperature in the right range, it will move some chemicals around. This is used to make nerve cells that send a message towards the brain whenever they experience a certain temperature.

Because evolution does all its best work the night before the deadline while on a Code Red Mountain Dew bender, the opened-by-temperature portal proteins are mostly copied from opened-by-a-specific-chemical portal proteins. All of them, in fact, still open for specific chemicals, which means there exist out in the world liquids you can put in a bottle that most animals will instead perceive as "a temperature between 8 and 26 degrees" So things can get a little weird.

Temperature-opening portal proteins:

TRPA1 Opens for temperatures below 12C (not air temperature, skin or body temperature, so you might be kind of in trouble when this happens). Used by hunting snakes to detect where heat isn't so they can find prey. Feels painful in an itchy sort of way.

This one also opens for allyl isothiocyanate. Many plants have evolved to take advantage of the existence of a chemical most animals perceive as itchy pain, especially horseradish and wasabi. Allyl isothiocyanate is harmful to plants, so they keep two separate components in tiny compartments. When an animal bites the plant, the compartments break open their contents mix to create allyl isothiocyanate.

"This plant tastes like itching" is a good defense against almost all animals, but some humans have taught themselves to appreciate the taste of itching.

TRPM8 Opens for temperatures between 8 and 26 degrees. Opens for menthol (peppermint, spearmint, wintergreen) and linalool (roses, orange blossoms, basil). Feels cool or cold.

"This plant tastes like cold" is a somewhat less effective defense against being eaten than "this plant tastes like itching" but it's a more widespread defense because TRPM8-activating chemicals don't harm plants and don't need elaborate two-part storage.

TRPV4 Opens for temperatures from 27-37 C. I'm not sure what this one feels like, or if even feels like anything, since it covers normal human body temperatures. Whatever feeling we get from this one, we're feeling it nearly all the time.

Plants do make a chemical that tastes like this temperature, and it can repel nonhuman creatures with different body temperatures: allicin, the flavour of garlic. Like allyl isothiocyante, it is stored in two compartments inside the plant, and combined when the plant is bitten.

Maybe this is why vampires abhor garlic. There is a feeling that, as humans, we always have. Something we don't notice, something deeper than touch. That feel disappears forever when you become a vampire, except those unbearable moments when garlic returns to you for a fleeting moment the experience of lost humanity.

TRPV3 Opens for temperatures 33-39 degrees. Opens for eugenol, found in cinnamon, nutmeg, bay leaf, holy basil, ginger, allspice, and cloves. Feels like warmth.

Plants with high quantities of eugenol, like holy basil and Japanese star anise, are sometimes sacred to buddhists because they smell nice and bugs don't like to eat them, so you can burn them as incense without worrying about all the little crawly guys.

Humans apparently think food that tastes like "warm" is comforting.

TRPV1 Opens for temperatures over 43 degrees. (The one I was experiencing in the overheated dome, which I had never felt from air before) Opens for capsaicin, the active chemical in hot peppers. Opens for the combination of temperature and acidity of fevers and infected wounds. This one we feel as pain, as burning, as flame.

TRPV1 says: Your flesh is failing, and your doom is very near.

Humanity says: This is incredible. We are going to breed plants that cause this sensation as much as possible, and we will spend thousands of years getting it right. We are going to dry this and powder this and flake it and grill it and ferment it and eat it with everything.

And when we leave earth and go into space, we take hot peppers with us. Without gravity, fluid builds up in nasal passages, and astronauts sort of have colds the entire time they're in space and can't smell food very well. But the Nearness Of Your Doom is not a smell and is not perceived by the nose, so - with their doom always on the other side of ten centimeters of insulated aluminum - astronauts can taste hot peppers. In 2002, Peggy Whitson, commander of the ISS, jokingly refused to let a replacement crew on board until they handed over the hot sauce.

We are a strange and wonderful species.

[marinamd29-stopharassingpeople]

Hi, Sorry, for disturbing you. I have been dealing with Marina's bullshit for a while now, and came across your blog just recently. I think I found a way of dealing with her, at least for myself, but she also harrassed my friends. I'll add some links to this, though I did not make all her numerous posts public.

There are more of that sort, too many to list them all here.

About my friends she has it in for both of them. Ano1 Ano2 I wrote the story she complaints about after she sent me various messages and sent 100 messages to one of my friends in one night alone Ano3 Ano4 Ano5

full disclosure.

i planned to leave it alone, because i was away while this was happening, and i, stupidly, was giving her a benefit of a doubt that she would chill. well. she didn't. so i'm posting everything i received in that time.

feel free to send in more for documentation purposes

[ao3wincest]

Forbidden love

read it on AO3 at https://ift.tt/R2hN0sF by ano1e Sam have a secret that Dean doesn’t know, a deep down hidden secret that Dean could understand.At least that’s what he told himself, is disturbing and disgusting and Dean would hate him forever and leave him because he is a freak if he knew. Words: 1151, Chapters: 1/5, Language: English Fandoms: Supernatural (TV 2005), Supernatural (TV 2005) RPF Rating: Mature Warnings: Creator Chose Not To Use Archive Warnings Categories: M/M Characters: Dean Winchester, Sam Winchester, John Winchester Relationships: Dean Winchester/Sam Winchester Additional Tags: Bottom Dean Winchester, Bottom Dean Winchester/Top Sam Winchester, Underage Sam Winchester, Sam Winchester Loves Dean Winchester read it on AO3 at https://ift.tt/R2hN0sF

[tumimmtxpapers]

ANO1-Mediated Inhibition of Cancer Ferroptosis Confers Immunotherapeutic Resistance through Recruiting Cancer-Associated Fibroblasts

The application of immunotherapy in gastrointestinal (GI) cancers remains challenging because of the limited response rate and emerging therapeutic resistance. Combining clinical cohorts, multi-omics study, and functional/molecular experiments, it is found that ANO1 amplification or high-expression predicts poor outcomes and resistance to immunotherapy for GI cancer patients. Knocking-down or inhibiting ANO1 suppresses the growth/metastasis/invasion of multiple GI cancer cell lines, cell-derived... http://dlvr.it/Sr28GB

[fluke-fanzine]

[LINK IN BIO] Fluke 18 is now available! This issue focuses on outsider art and culture. We caught up with filmmaker, photographer and cinematographer Bill Daniel—creator of the experimental documentary film Who is Bozo Texino?—and talked about zines, Aaron Cometbus and Bill's train-hopping adventures that eventually led to discovering the moniker writers of the US railways system. Susan A. Phillips of Pitzer College and author of The City Beneath: A Century of Los Angeles Graffiti has been researching graffiti since 1990. Susan shares with us her vast knowledge and discoveries, including graffiti dating back to the early 20th century by legendary hobo A-No. 1. We welcome back Gary Floyd (Dicks, Sister Double Happiness). Gary talks about growing up in Gurdon, Arkansas, moving to Austin and forming the Dicks, and touring with Nirvana with Sister Double Happiness. Sergej Vutuc—photographer, zine maker, skateboarder and musician now based in Paris, France—contributes his skateboarding photographs that are like none other. buZ blurr of Colossus of Roads fame writes about connecting with Bill Daniel in the early '90s, during Bill's search for Bozo Texino. buZ also contributed art for this issue. Linda Kite writes about her relationship with D Boon (Minutemen) and the Desolation Center shows around LA in the early to mid '80s. Also in this issue you'll find more art and photographs as well as writings about skateboarding, music, art and friendship. It is my hope that this issue will inspire you to keep searching, keep creating and keep living through these troubled times. 56 pages, $4. Check the different options on the site. Buy the zine, shirt and sticker for only $20! Thanks so much for the support! #flukefanzine #flukezine #zine #zines #fanzine #fanzines #billdaniel #whoisbozotexino #mostlytrue #moniker #monikers #susanaphilips #chazbojorquez #ano1 #buzblurr #colossusofroads #garyfloyd #dickshatepolice #sergejvutuc #lindakite #desolationcenter #minutemen #skateboarding #thankyouskateboarding #graffiti #punkzine #cometbus #aaroncometbus #nxoeed #punkzine #artzine (at Phoenix, Arizona) https://www.instagram.com/p/CCXHHxADqqL/?igshid=11vo3o85k8ev4

[rlimarjbr]

#Aventuras #Macabras #Ano1978 #Anos70 #HQ #AventurasMacabras #Ano1 #N10 #Número10 #Capitão #Mistério #Terror #Horror #CapitãoMistério #Comics #Quadrinhos Uma #Coleção de #Histórias de #Vampiro O #Castelo da #Tirania Nas #Sombras da #Noite #Demônios em #Duelo #Gibi #RLimaRJBR #Português #RJ #Brasil ... https://www.instagram.com/p/B5_rxpEno77/?igshid=1pxf830v70x4x

[sandragraeff-blog]

Voltei...

[guiadelugaresimpossiveis]

Tava marcando aqui. Olhando pro mato. Pouso-me um grande urubu rei magnífico, na porteira/do meu lado. Espantei de dar um pulo. Que animal extraordinário. Pensei. - HUMANO, HUMANO!!! ele disse, e continuou: -demasiado humano chegastes em 2017 heim !!? Quem diria.!? Esse ano parece q vai tudo se agitar e bagunçar ainda mais. Vai piorar tudo, como vcs dizem "o bicho vai pegar". Política, guerra, furacão 🌋........mas ó. Segue no amor. Segue trabalhando com capricho e carinho. E acima de tudo com o respeito e amor ao próximo. Não entre em debates, evite discussões e a vontade de querer ter certeza de tudo. A FONTE CRIATIVA te ampara junto com todos os seres desse amado planeta. Ampara com amor universal. Vastidão de amor cósmico. Esse É o ano 1 ................. Fiquei de cara. Ele abriu bem as asas deu um grito e saio voando. Fiquei olhando aquela ave desaparecer no céu. Derrepente me deu um estalo. Sai correndo e fui pintar! #reformamundial #valorespessoais #fomentoaoamor #arte #pintura #tintaferrugem #foratemer #arteatomica #artistaquantico #pinturasatomicas #internationale #monumentoaohomemmoderno #2017 #ano1 #salvetodosorixás #budas #povodocéu #meusguias #povodaterra #povodasaguas #povodoar #salveDonaIsabelRainhaDosAnjos 👽🍀✨❤✨📸 @anameliabrito !!!!! (em Mairiporã)

[maletofujoshi]

BTW anodyne 1 is not exactly necessary context for anodyne 2, like, you may recognize “Hey! the floating face thing with one line of dialogue!” but like theres not much especially significant to the main story, which is all new characters and new locations. but also ano1 is also good in a very different way and i liked it a lot and its short and cheap. you might get some things out of playing ano1, seeing the evolution of the art and gameplay and writing, but like, Ehhhh, the story and experience of ano2 stands entirely on its on

[omniheros]

                                   * No.10/ [SuperHero] *

                                          Indie Benjamin Tennyson

                                                             |Side blog|

                                                 Crossover and OC Friendly

                                                 Unmasked By Ano1/Omni

[darllannogueira]

POOL PARTY SUMMER #ano1 Uma Pool Party dedicada ao público Masculino que curte sair da rotina sem regras! 😋😈🍻🎊🕺🏊‍♂🎶🤳 ✅Data 07 e 08 de Setembro ✅Horário 11:00hrs da manhã no sábado até as 16:00hrs do domingo 📍Local Av. Dr. Cláudio José Gueiros Leite, 7508 Pau Amarelo-Paulista/PE ✅ Valor R$50,00(Depósito ou Transferência) R$55,00 (Cartão de Crédito)💳 ⚠O valor já inclui o JANTAR do ( Sábado ), CAFÉ DA MANHÃ ( Domingo ) e ALMOÇO ( Domingo ). ✅Vendas de Bebidas no Local ✅Bancos para depósito👇 Caixa econômica Federal - Poupança Agência: 3220 Operação: 013 Conta: 00002242-6 Banco Santander - Conta Corrente Agência: 4588 Conta: 01028359-7 Para Transferência, segue nome completo do titular: *Darllan Nogueira da Silva* Ao depositar não esqueçam de mandar o comprovante pelo Whatsapp: 81 99767-9997 (Darllan) 📳Maiores Informações: 81 99767-9997 (Darllan) 81 98728-4345 (Leo) #pool #party #summer #gay #boys #after #man (em Pau Amarelo, Pernambuco, Brazil) https://www.instagram.com/p/B1cmfK0g7_o/?igshid=rqxl7pzw4byg

[dhilewis]

"Sabe que minha vida é na contra mão" 🎶 #BLOCOVOLEIFOLIA #ano1 #drag ❤😙 (em Venturosa, Pernambuco, Brazil)

[ichorhexrt]

Heyo its your local hellspawn ano1 back at it again at krispy kreme  With the poor discussions, this time in the form of a revamped blog, used to go by the name Demontorn for another muse.

But now houses Nero, the little shit devil hunter everyone loves from Dmc5 (with a dmc4 verse) and no spoilers for some time cause im nice.

So if you would like to interact with a lone wolf devil hunter, like or reblog this little call to action and i just might check ya out~

Ano1 out

[keysunbound]

Since i can’t make a normal promo and these get around faster....

Do you like losers and oc’s? how bout kingdom hearts, well if that seems like something you’d be interested in, hit me up, iv’e got rp experience of about 5 years now on tumblr, more so on other sites.

You my call me X or Ano1, or Rise, honestly i don’t care, just hit that like button for a literal bean boy to be part of your day.

[darknesstorn]

“My Friends are my power-

                                    My world-

                                               And without them, What power do i have?”

                      Indie Sora from the series Kingdom Hearts as written by Ano1 (Rise)

[rlimarjbr]

#Aventuras #Macabras #Ano1978 #Anos70 #HQ #AventurasMacabras #Ano1 #N9 #Capitão #Mistério #Terror #Horror #CapitãoMistério #Comics #Quadrinhos Uma #Coleção de #Histórias de #Vampiro O #Senhor dos #Vampiros #Sangue #Envenenado A #Rainha dos #Piratas #Gibi #RLimaRJBR #Português #RJ #Brasil ... https://www.instagram.com/p/B58YLnfHpev/?igshid=xqt2pemd6nqx