#angiotensin converting enzyme
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jppres · 2 years ago
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The role of plasma angiotensin-converting enzyme and interleukin-6 levels on the prognosis of non-dialysis chronic kidney disease patients
Image: Max Pixel Article published in J. Pharm. Pharmacogn. Res., vol. 11, no. 1, pp. 55-62, January-February 2023. DOI: https://doi.org/10.56499/jppres22.1518_11.1.55 Hendri Susilo1,2**, Mochammad Thaha3,4, Budi Susetyo Pikir1,2, Mochamad Yusuf Alsagaff1,2, Satriyo Dwi Suryantoro3,4, Ifan Ali Wafa5, Nando Reza Pratama5, David Setyo Budi5, Bayu Satria Wiratama6, Citrawati Dyah Kencono…
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deinheilpraktiker · 1 year ago
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Es wurde festgestellt, dass die ultralange komplementaritätsbestimmende Region H3 von Rindern mit Sarbecoviren kreuzreagiert
In einer kürzlich veröffentlichten Studie in der Zeitschrift für biologische ChemieForscher führten eine In-vitro-Analyse durch, um ultralange bovine schwere Ketten zu isolieren, die eine Bindung mit dem schweren akuten respiratorischen Syndrom-Coronavirus 2 (SARS-CoV-2) und verwandten Coronaviren (CoVs) zeigten. Studie: Ein boviner Antikörper, der über eine ultralange…
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awakenlng369 · 2 years ago
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EGGS CURE COVID SCIENCE SAID NOV 22 - EGG SHORTAGE IN UK NOVEMBER 2022
My Source TikTok “EGGS CURE MULTIPLE COVID STRAINS” Science Said November 2022 Egg Shortage November 2022 Published on Pubmed 2 Studies EGG YOLKS CURE COVID TIKTOK TRUTHS https://vm.tiktok.com/ZGJm5Xfm2/ Immunoglobulin yolk targeting spike 1, receptor binding domain of spike LAYING HENS PRODUCE THE IgY – CURE FOR COVID NOVEMBER 2022https://pubmed.ncbi.nlm.nih.gov/36183680/ Our results…
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covid-safer-hotties · 3 months ago
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Patients With Long-COVID Show Abnormal Lung Perfusion Despite Normal CT Scans - Published Sept 12, 2024
VIENNA — Some patients who had mild COVID-19 infection during the first wave of the pandemic and continued to experience postinfection symptoms for at least 12 months after infection present abnormal perfusion despite showing normal CT scans. Researchers at the European Respiratory Society (ERS) 2024 International Congress called for more research to be done in this space to understand the underlying mechanism of the abnormalities observed and to find possible treatment options for this cohort of patients.
Laura Price, MD, PhD, a consultant respiratory physician at Royal Brompton Hospital and an honorary clinical senior lecturer at Imperial College London, London, told Medscape Medical News that this cohort of patients shows symptoms that seem to correlate with a pulmonary microangiopathy phenotype.
"Our clinics in the UK and around the world are full of people with long-COVID, persisting breathlessness, and fatigue. But it has been hard for people to put the finger on why patients experience these symptoms still," Timothy Hinks, associate professor and Wellcome Trust Career Development fellow at the Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre senior research fellow, and honorary consultant at Oxford Special Airway Service at Oxford University Hospitals, England, who was not involved in the study, told Medscape Medical News.
The Study Researchers at Imperial College London recruited 41 patients who experienced persistent post-COVID-19 infection symptoms, such as breathlessness and fatigue, but normal CT scans after a mild COVID-19 infection that did not require hospitalization. Those with pulmonary emboli or interstitial lung disease were excluded. The cohort was predominantly female (87.8%) and nonsmokers (85%), with a mean age of 44.7 years. They were assessed over 1 year after the initial infection.
Exercise intolerance was the predominant symptom, affecting 95.1% of the group. A significant proportion (46.3%) presented with myopericarditis, while a smaller subset (n = 5) exhibited dysautonomia. Echocardiography did not reveal pulmonary hypertension. Laboratory findings showed elevated angiotensin-converting enzyme and antiphospholipid antibodies. "These patients are young, female, nonsmokers, and previously healthy. This is not what you would expect to see," Price said. Baseline pulmonary function tests showed preserved spirometry with forced expiratory volume in 1 second and forced vital capacity above 100% predicted. However, diffusion capacity was impaired, with a mean diffusing capacity of the lungs for carbon monoxide (DLCO) of 74.7%. The carbon monoxide transfer coefficient (KCO) and alveolar volume were also mildly reduced. Oxygen saturation was within normal limits.
These abnormalities were through advanced imaging techniques like dual-energy CT scans and ventilation-perfusion scans. These tests revealed a non-segmental and "patchy" perfusion abnormality in the upper lungs, suggesting that the problem was vascular, Price explained.
Cardiopulmonary exercise testing revealed further abnormalities in 41% of patients. Peak oxygen uptake was slightly reduced, and a significant proportion of patients showed elevated alveolar-arterial gradient and dead space ventilation during peak exercise, suggesting a ventilation-perfusion mismatch.
Over time, there was a statistically significant improvement in DLCO, from 70.4% to 74.4%, suggesting some degree of recovery in lung function. However, DLCO values did not return to normal. The KCO also improved from 71.9% to 74.4%, though this change did not reach statistical significance. Most patients (n = 26) were treated with apixaban, potentially contributing to the observed improvement in gas transfer parameters, Price said.
The researchers identified a distinct phenotype of patients with persistent post-COVID-19 infection symptoms characterized by abnormal lung perfusion and reduced gas diffusion capacity, even when CT scans appear normal. Price explains that this pulmonary microangiopathy may explain the persistent symptoms. However, questions remain about the underlying mechanisms, potential treatments, and long-term outcomes for this patient population.
Causes and Treatments Remain a Mystery Previous studies have suggested that COVID-19 causes endothelial dysfunction, which could affect the small blood vessels in the lungs. Other viral infections, such as HIV, have also been shown to cause endothelial dysfunction. However, researchers don't fully understand how this process plays out in patients with COVID-19.
"It is possible these patients have had inflammation insults that have damaged the pulmonary vascular endothelium, which predisposes them to either clotting at a microscopic level or ongoing inflammation," said Hinks.
Some patients (10 out of 41) in the cohort studied by the Imperial College London's researchers presented with Raynaud syndrome, which might suggest a physiological link, Hinks explains. "Raynaud's is a condition of vascular control or dysregulation, and potentially, there could be a common factor contributing to both breathlessness and Raynaud's."
He said there is an encouraging signal that these patients improve over time, but their recovery might be more complex and lengthy than for other patients. "This cohort will gradually get better. But it raises questions and gives a point that there is a true physiological deficit in some people with long-COVID."
Price encouraged physicians to look beyond conventional diagnostic tools when visiting a patient whose CT scan looks normal yet experiences fatigue and breathlessness. Not knowing what causes the abnormalities observed in this group of patients makes treatment extremely challenging. "We need more research to understand the treatment implications and long-term impact of these pulmonary vascular abnormalities in patients with long-COVID," Price concluded.
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snarp · 2 months ago
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Oops.
Relevant catechin here is epigallocatechin gallate aka EGCG. I'd noticed that the lisinopril didn't seem to be doing anything most days... This is just one 10-person study, but I might have just made it 11. Thanks, @ms-demeanor .
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coupleoffanfics · 1 year ago
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Two Are Better Than One
CW: Mentions of suicidal ideation.
Part 1 | Part 2
Half of the day y/n was left alone. She was given a few books to read, but she didn't bother touching them. She would have thrown them at whoever came through the door. It didn't matter if it was Jeremiah or Ecco, just as long as it hurt. But that wouldn't be the best thing to do. You can catch more flies with honey as they say.
She believed that they could still talk this out. If they hear each other out then they could move on from this. They moved on from a lot of things and this could be one of them. She didn't care how delusional it sounded, she was always in it for the long hall when Jeremiah was involved.
Reverting to her old ways y/n slept her worries away. Whenever things become too much she always rolled into bed and slept. It wasn't easy to sleep this time with her one hand being cuffed but she managed somehow.
She would be woken up by Jeremiah. "It's time to take your medicine." She slightly grimaced when she opened her eyes but sat up and gave him a confused look. "Ecco took everything you needed from your apartment." He explained as he handed her the glass of water.
It would have been so easy for y/n to throw it at him or just smash it against his forehead until it broke. It would be easy, but it'd only get her into trouble.
"Open wide." y/n felt her face heat up hearing him say that. This felt a bit humiliating and he must have found it amusing by the grin on his face. Not wanting to be perceived as reluctant or defiant, she opened her mouth so that he put the pill in her mouth. After that, she closed her mouth and took a sip of the water.
She almost choked on the water when she made eye contact with him. His eyes were one of the many things she liked about him. A simple glance made her flustered, and when his eyes were on her it made her squirm. He still has the effect but it didn't make her squirm or giggle like it used to. It could be because of the context of this situation, but his now-green eyes always put her off.
She took her medication without too much trouble. She said a quiet thank you before holding the cup out to him trying to hand it back. "You have one more pill to take."
"Another one? I only take Zoloft."
"I know, darling, but you have to take this."
y/n was taken aback a bit by the pet name. She was always the one to call him a pet name. Sometimes just to embarrass him, but he'd always just call her by her name. She quickly shook that out of her head to ask, "What is it?"
"ACE."
Angiotensin-converting enzyme, y/n remembers her doctor recommending it. She denied it along with any other medication recommended for her heart failure because she wanted to die faster.
She didn't want to prolong the inevitable. She didn't want to feel hopeless and numb anymore. She didn't want to watch the only person in her life devolve into madness. She didn't want to wake up the next morning.
Jeremiah must have known exactly what y/n was thinking too. He gave her a hard look and he dropped his grin after telling her the name of it. He wonders what she'd say or do while he watches the flash of realization appear on her.
It was interesting because Jeremiah didn't know what route she'd take. This morning showed her defiance, but aggressiveness wasn't in her nature. He knew she wasn't the smartest person at times, yet she knew there wasn't a freedom of choice. How she reacts will determine how restricted things will be. Even then he can't always predict what she'll do regardless of their years of being together and how she'd tell him just about every little thing.
But he doubts that she'd openly tell him she wanted to kill herself faster. Of course, he knows her history of mental instability. He's watched her fall into those depressive lows multiple times. Suicide was a different story. Anything about suicide or even self-harm is off the table of discussion for y/n. It was least off the table when having casual conversations.
Suddenly y/n opened her mouth much to Jeremiah's delight. Silently complying. Once she had successfully taken the ACE, he lightly patted her cheek, "Good girl." He watched as her face contorted into embarrassment for a moment. He knew he had power over her, but he didn't know how much until now. It was like their roles had been reversed.
y/n slightly moved her head to the right as if that would stop him from touching her face. "Miah, honey," She started with an anxious smile, "Why do feel like you have to do this?" Right after the question came out of her mouth he raised an eyebrow and slightly squinted his eyes. She felt her mouth go dry as she was scrambling to explain, "I mean, I understand what you mean when you explained earlier. I think we could compromise."
Jeremiah slowly spoke while holding back a laugh, "Compromise? You want to compromise with me?" Her lips moved to the left and she slightly pounded. She was being serious. He bit down on his tongue so a laugh couldn't escape. Quickly inhaling and exhaling, he asked her to continue.
Still full of hope, or what could be called delusion, y/n spoke of different ideas. That's maybe he could still take that blood sample or not at all. She'll never doubt or bring up her past concern about his sanity. In each idea, she promised not to leave the bunker. Jeremiah would be lying if he said her ideas weren't tempting.
But not tempting enough. The whole time his amused smile did not filter once because he knew what his final verdict was.
"No." Her shoulders slumped and a defeated sigh came out. He needed her to know that there was no point in trying to fight. That she didn't have any control and that she'd be better off listening to him. There wasn't going to be anyone else that she'd want or need, but him.
"Someone's going to notice I'm gone. My therapist, my professors, and my family." He rolled his eyes at the last example. "I've already dropped your therapist for you through your email. College isn't a problem for you anymore. As for your family."
She didn't like how he dragged out 'your family' with such disdain. "Do you think they'll search for you? They'll send a few search teams and act sad, but they aren't going to look for you." She mentally scolded herself for being so quick to believe him. Even if it was just for a second. It was a second that she believed that they were anything, but moral people.
"You know that's a lie. When Jerome-"
Jeremiah's mood soured at the name. "Who wouldn't be worried? Jerome stands for nothing and will burn everything. When I–" He stopped to prevent himself from becoming so pressed, "Can't you see that they're just acting at this point? They wouldn't be pretending if didn't make them look heartless."
"Because they aren't heartless. You've never even met them, so I don't think it's even fair to judge them." Jeremiah couldn't understand why after all this time, she still defends them. The nights when poured out her feelings towards her family are still fresh in his mind. She'd get so emotional when talking about how alone she was and how she wished they could be a normal family.
"You're right, I never met them because they never showed up to anything. Not once have they shown up to any of your art galleries or even your graduation. I had to comfort you because they always upset you somehow. You've been fine without them for years, and you'll be fine without them now."
y/n let out a frustrated sigh. The Wayne family was complicated and held many secrets. Secrets that she couldn't talk about meaning he'd never have the full picture. They were good people deep down, she knows it. It wasn't fair for her to demand their attention after they came back from saving lives. Yet it reminded her that she wasn't worthy of their time or effort after she quit.
"They're good people, it's just that they're always so busy."
"Your father or brothers can't give you an hour of their time? Jesus Christ, y/n, I know you have attachment issues but come on." Her eyes widen in surprise.
"I don't have attachment issues," She balls her hands into fists, "I'm mentally sound and have normal, healthy relationships with others."  Her words made Jeremiah tisk, yet almost smile at the same time.
"You're accusing me of being mentally ill, but look at yourself. You had to go to therapy weekly, every few years you'll end up in the ER for suicidal ideation, and you rely on medication to make you feel normal. This morning you attacked Ecco when she did nothing wrong." The look of hurt painted y/n's face.
"Okay, but I wasn't-"
He faked a shocked expression like he was outraged by the few things she had said. "y/n, you don't have to yell at me. I know you're insecure about your mental health, but you have to accept that you are nothing without anyone." She tried to say something, but he spoke over her. "It's clear you aren't ready to talk about this by how emotional you are. I'll give you some time to calm down."
He got up and began making his way out of the room. As he was leaving and closed the door he could hear y/n begging him to come back. To not leave her alone. That she was sorry, in a perfect world he might have gone back to comfort the distraught girl, but there was too much work and so little time.
When passing by Ecco he said, "If she doesn't quite down give her midazolam."
Right after y/n was handed her diploma, she quickly walked off the stage with a clenched jaw and a big smile. Jeremiah sighed as he looked at the text he received not long after she fled. 'I'm ready to go. I'll be waiting in the car.' He glanced around the people seeing the families hugging and praising their loved ones. Yeah, he could understand and he didn't want to be there any longer himself.
Leaving the school he found y/n sitting in the passenger seat with the side of her head resting against the window. He couldn't tell because it was dark out, but he was sure her eyes were slightly reddened. While he got behind the steering wheel he asked, "Do you want to go back to my place?" She nodded her head.
y/n has been making it a habit of going to Jeremiah's place instead of home. He doesn't understand it personally, but he did understand the reasoning behind it to a certain extent. She told him of how lonely Wayne Manor was because everyone was doing their own thing. Saying that she didn't want to disturb their work which he found ironic because she'd always try to distract him when he was doing something. Still, his place was less lonely because he still lived with his Uncle.
During the ride back to his apartment the radio filled the silence. Every so often he'd glance at her to see that she was staring out the window. The look on her face didn't tell him that she was numbing herself by ignoring her feelings. Instead, her eyebrows were furrowed as hugged herself. He would have liked to know what she thinking, but he didn't want to push her to tell him.
When they made it in front of the mixed-use building they just sat there. The radio and the purring engine no longer provided a slight distraction. Jeremiah waited a moment for y/n to move. It took a little longer, but eventually, she pulled herself out of the car. Her movements held no energy in them and it made her seem like she had just got out of her nine-to-five.
She didn't grab his hand and intertwine their fingers just to feel close. She only walked beside him slightly slouching. He wanted to reach out for her hand, but there was this pit in his stomach that made him anxious. This mildly intense feeling made him worry about what he should do.
Comfort. He didn't know how to comfort her let alone anyone. Yes, there were moments when she'd open up about what was bothering her but all he did was be there. Listen to the [hair color] haired girl ramble more so towards herself than him. If she wanted to, which was often, she asked him for a hug or something that didn't require him to do much.
He could do that right now, right? A hug or a kiss on the cheek– no. It was too risky. This was uncharted territory for Jeremiah, to be the one to entail any physical affection. When y/n suddenly held his hand or pecked his cheek that'd fluster him a bit. Flustered doesn't describe what he feels when thinking of reaching out to her hand because his heart races and his hands start to feel shaky. Panicked might be the word.
Jeremiah's thoughts were suddenly cut off when they entered the apartment and were greeted by a sweet aroma. He was surprised his uncle didn't jump out to greet y/n into their home as if she doesn't sleep there four times a week. y/n didn't seem bothered and made a beeline toward Jeremiah's room. He could hear her flop onto the bed.
He wandered around the kitchen to find a note with a cake next to it.
'I might be still working by the time you get back. To congratulate her on graduation, I baked a cake for her. Tell her I said congratulations.'
Glancing, he slightly smiled at his uncle's gesture. Putting down the piece of paper he entered his room to find y/n had rolled herself up in his blankets. Hearing his footsteps she opened her eyes. "My uncle made you a cake and wanted to tell you congratulations."
y/n only lazily hummed a response but he could see her face soften. She watched Jeremiah from his bed as he pulled out the chair from his desk to sit on it. Then listened to him write and scribe on some paper while she stared at the ceiling thinking to herself.
It felt awkward. At least to him. Once again he didn't know what to do except wait. That in itself is fine and normal for them, but this time just felt different. Maybe it was because the problem was different. He didn't know except that he didn't want to wait for her. Wait for her to talk or cling to him for comfort. He wanted to do something. He had to do something.
"Do you want to talk about it?" His quiet, almost soft voice startled her. Looking at him, she slightly smiled, "Do you think I was stupid to get my hopes up?"
He struggled to think of a response. He wanted to say the right thing and think of a long response. Yet he only blurted out, "Of course not." Not getting a response immediately made him slightly panicked. Fearing that he had somehow worsened her mood with his words.
"Do you…" The question y/n was going to ask quickly died when she realized it would have been too specific to ask. So she quickly thought of a different way to ask her original question, "Do you think I'm worthless?" Her words hung in the air before she spoke up again. "Nevermind. Forget what I asked, it's stupid."
"y/n…"
She looked at his face. Those deep blue eyes look back at her with a mixture of emotions. The ones she could identify were pity or sadness. It made her shift her eyes away out of embarrassment. In an attempt to move away from her weird question, she asked him to please lie in bed with her.
Now they lay on their side holding each other. She had her ear resting against his chest while his chin sat atop her head. Being close to each other like this made it seem like tonight was just like any other night.
The steady thumping of his heart was putting her to rest until it started picking up the pace. He took a deep breath before quietly telling her, "I love you, y/n."
She broke out into a huge smile. It was the first time he ever said this. When she says it, she never expected a response back because of how flustered he'd looked after hearing it. Not wanting to show how much of a big deal it was to her, she earnestly responded.
"I love you too, Xander, and I won't ever stop."
Masterlist I might as well make this into a series, but I have no ideas for the next part. The heart failure plotline is inspired by an old Jeremiah x Reader story I read a while ago. I'll look for it later, but I remember liking the idea because I found it beautifully horrifying. If I do find the fanfic I'll link it here.
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willowreader · 1 year ago
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Story out! An albumin fused ACE2 design that blocks all SARS-CoV-2 variants. The design has a long plasma half-life and can be delivered in a needle-free manner across mucosal surfaces.
This is fantastic news. A COVID blocker is exactly what we need.
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petfurri · 4 months ago
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Captopril for Dogs: Benefits, Dosage, Side Effects, and More
Captopril for Dogs
Captopril is an angiotensin-converting enzyme (ACE) inhibitor commonly used in veterinary medicine to manage heart conditions in dogs, particularly congestive heart failure (CHF) and systemic hypertension (high blood pressure). Initially developed for human use, captopril has found its place in treating canine patients with cardiovascular issues, offering numerous benefits but also requiring careful administration and monitoring due to potential side effects.
Understanding Captopril and Its Mechanism of Action
Captopril works by inhibiting the angiotensin-converting enzyme, which is responsible for converting angiotensin I into angiotensin II, a potent vasoconstrictor. Angiotensin II causes blood vessels to narrow, leading to increased blood pressure and making the heart work harder. By blocking this conversion, captopril allows blood vessels to relax and widen, reducing the workload on the heart and lowering blood pressure. This action is particularly beneficial for dogs suffering from CHF, as it helps to improve blood flow and reduce fluid buildup in the lungs and other tissues.
Benefits of Captopril for Dogs
Managing Congestive Heart Failure (CHF): CHF is a common condition in dogs, especially in older or certain breeds like Cavalier King Charles Spaniels. Captopril helps manage CHF by reducing the resistance the heart faces when pumping blood, thus improving cardiac output and reducing symptoms like coughing, difficulty breathing, and lethargy.
Lowering Blood Pressure: For dogs diagnosed with systemic hypertension, captopril can effectively lower blood pressure, preventing damage to organs such as the kidneys, eyes, and brain, which can result from prolonged high blood pressure.
Improving Quality of Life: By easing the burden on the heart and lowering blood pressure, captopril can significantly improve a dog's overall quality of life. Dogs may exhibit increased energy levels, better appetite, and greater overall comfort as a result of treatment.
Potential Renal Protection: In some cases, captopril may offer renal protection by reducing the progression of kidney disease, particularly in dogs with proteinuria (protein in the urine), which is often associated with high blood pressure.
Dosage and Administration
The dosage of captopril for dogs must be carefully determined by a veterinarian, as it varies depending on the dog's weight, the severity of the condition being treated, and the presence of any other health issues. Captopril is usually administered orally, with or without food, typically two to three times a day.
Typical Dosage: The usual starting dose is around 0.5 to 2 mg per kg of body weight, given every 8 to 12 hours. The dosage may be adjusted based on the dog’s response to the medication and any side effects observed.
Monitoring: Regular monitoring is crucial when a dog is on captopril. Blood pressure, kidney function (via blood tests for creatinine and blood urea nitrogen levels), and electrolyte levels should be checked periodically to ensure the medication is working effectively without causing harm.
Potential Side Effects of Captopril
While captopril can be highly beneficial, it also carries the risk of side effects, particularly if not used correctly. Some of the potential side effects include:
Gastrointestinal Issues: Dogs may experience vomiting, diarrhea, or loss of appetite. These symptoms are usually mild but should be reported to the veterinarian if they persist.
Hypotension (Low Blood Pressure): As captopril lowers blood pressure, there is a risk that it may cause blood pressure to drop too low, leading to weakness, dizziness, or fainting. This is more likely to occur in dogs that are dehydrated or have other underlying health conditions.
Kidney Dysfunction: Captopril can affect kidney function, particularly in dogs with pre-existing kidney issues. It’s important to monitor kidney parameters closely during treatment to avoid exacerbating any renal problems.
Hyperkalemia (High Potassium Levels): Captopril can cause an increase in potassium levels, which can lead to dangerous heart rhythms if not managed properly. Regular blood tests are essential to monitor electrolyte levels.
Coughing: A persistent dry cough is a less common side effect but can occur due to the buildup of bradykinin, a substance that captopril can increase in the body.
Allergic Reactions: Though rare, some dogs may have an allergic reaction to captopril, manifesting as itching, rash, or swelling. Immediate veterinary attention is required in such cases.
Precautions and Considerations
Captopril should be used with caution in dogs with pre-existing kidney disease, dehydration, or electrolyte imbalances. It should not be used in dogs that are pregnant, as it can cause harm to the developing fetus. Additionally, it’s important to inform the veterinarian of any other medications the dog is taking, as captopril can interact with other drugs, including diuretics and nonsteroidal anti-inflammatory drugs (NSAIDs), potentially leading to adverse effects.
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didanawisgi · 7 months ago
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dyingroses · 1 year ago
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The different meanings I associate with the same initials:
HR
human resources
heart rate
RR
rest and recreation
respiratory rate
BO
body odor
behavioral observation
SO
significant other
superior officer
CO
commanding officer
cardiac output
ACE
angiotensin-converting enzyme
adverse childhood experience
academic center for excellence
BC
before the common-era/before christ
birth control
because
RN
right now
registered nurse
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nursingscience · 2 years ago
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Medical Abbreviations on Pharmacy Prescriptions
Here are some common medical abbreviations you may see on pharmacy prescriptions:
qd - once a day
bid - twice a day
tid - three times a day
qid - four times a day
qh - every hour
prn - as needed
pc - after meals
ac - before meals
hs - at bedtime
po - by mouth
IV - intravenous
IM - intramuscular
subQ - subcutaneous
mL - milliliter
mg - milligram
g - gram
mcg - microgram
stat - immediately, right away
NPO - nothing by mouth
cap - capsule
tab - tablet
susp - suspension
sol - solution
amp - ampule
inj - injection
Rx - prescription
C - Celsius
F - Fahrenheit
BP - blood pressure
HR - heart rate
RR - respiratory rate
WBC - white blood cell
RBC - red blood cell
Hgb - hemoglobin
Hct - hematocrit
PT - prothrombin time
INR - international normalized ratio
BUN - blood urea nitrogen
Cr - creatinine
Ca - calcium
K - potassium
Na - sodium
Cl - chloride
Mg - magnesium
PO2 - partial pressure of oxygen
PCO2 - partial pressure of carbon dioxide
ABG - arterial blood gas
CBC - complete blood count
BMP - basic metabolic panel
CMP - comprehensive metabolic panel.
ECG - electrocardiogram
EEG - electroencephalogram
MRI - magnetic resonance imaging
CT - computed tomography
PET - positron emission tomography
CXR - chest x-ray
CTX - chemotherapy
NSAID - nonsteroidal anti-inflammatory drug
DMARD - disease-modifying antirheumatic drug
ACE - angiotensin-converting enzyme
ARB - angiotensin receptor blocker
SSRI - selective serotonin reuptake inhibitor
TCA - tricyclic antidepressant
ADHD - attention deficit hyperactivity disorder
COPD - chronic obstructive pulmonary disease
CAD - coronary artery disease
CHF - congestive heart failure
DVT - deep vein thrombosis
GI - gastrointestinal
UTI - urinary tract infection
OTC - over-the-counter
Rx - prescription
OD - right eye
OS - left eye
OU - both eyes.
TID - thrombosis in dementia
TDS - ter die sumendum (three times a day)
BOM - bilaterally otitis media (infection in both ears)
BT - body temperature
C&S - culture and sensitivity
D/C - discontinue or discharge
D/W - dextrose in water
ETOH - ethyl alcohol
FUO - fever of unknown origin
H&P - history and physical examination
I&D - incision and drainage
I&O - intake and output
KVO - keep vein open
N&V - nausea and vomiting
PERRLA - pupils equal, round, reactive to light and accommodation
PR - per rectum
QAM - every morning
QHS - every bedtime
QOD - every other day
S/P - status post (after)
TPN - total parenteral nutrition
UA - urinalysis
URI - upper respiratory infection
UTI - urinary tract infection
VO - verbal order.
XRT - radiation therapy
YOB - year of birth
BRBPR - bright red blood per rectum
CX - cervix
DVT - deep vein thrombosis
GB - gallbladder
GU - genitourinary
HCV - hepatitis C virus
HPI - history of present illness
ICP - intracranial pressure
IVP - intravenous pyelogram
LMP - last menstrual period
MRSA - methicillin-resistant Staphylococcus aureus
MVA - motor vehicle accident
NKA - no known allergies
PEG - percutaneous endoscopic gastrostomy
PRN - pro re nata (as needed)
ROS - review of systems
SOB - shortness of breath
TAH - total abdominal hysterectomy.
TIA - transient ischemic attack
Tx - treatment
UC - ulcerative colitis
URI - upper respiratory infection
VSD - ventricular septal defect
VTE - venous thromboembolism
XR - x-ray
w/c - wheelchair
XRT - radiation therapy
ASD - atrial septal defect
Bx - biopsy
CAD - coronary artery disease
CKD - chronic kidney disease
CPAP - continuous positive airway pressure
DKA - diabetic ketoacidosis
DNR - do not resuscitate
ED - emergency department
ESRD - end-stage renal disease
FFP - fresh frozen plasma
FSH - follicle-stimulating hormone.
GCS - Glasgow Coma Scale
Hct - hematocrit
Hgb - hemoglobin
ICU - intensive care unit
IV - intravenous
JVD - jugular venous distension
K - potassium
L - liter
MCH - mean corpuscular hemoglobin
MI - myocardial infarction
Na - sodium
NGT - nasogastric tube
NPO - nothing by mouth
OR - operating room
PCN - penicillin
PRBC - packed red blood cells
PTT - partial thromboplastin time
RBC - red blood cells
RT - respiratory therapy
SOA - short of air.
SCD - sequential compression device
SIRS - systemic inflammatory response syndrome
STAT - immediately
T - temperature
TPN - total parenteral nutrition
WBC - white blood cells
ABG - arterial blood gas
A fib - atrial fibrillation
BPH - benign prostatic hypertrophy
CBC - complete blood count
CO2 - carbon dioxide
COPD - chronic obstructive pulmonary disease
CPR - cardiopulmonary resuscitation
CT - computed tomography
CXR - chest x-ray
D5W - dextrose 5% in water
Dx - diagnosis
ECG or EKG - electrocardiogram
EEG - electroencephalogram
ETO - early termination of pregnancy.
FHR - fetal heart rate
GSW - gunshot wound
H&P - history and physical exam
HCG - human chorionic gonadotropin
I&D - incision and drainage
IBS - irritable bowel syndrome
ICP - intracranial pressure
IM - intramuscular
INR - international normalized ratio
IOP - intraocular pressure
LFT - liver function test
LOC - level of consciousness
LP - lumbar puncture
NG - nasogastric
OA - osteoarthritis
OCD - obsessive-compulsive disorder
OTC - over-the-counter
P - pulse
PCA - patient-controlled analgesia
PERRLA - pupils equal, round, reactive to light and accommodation.
PFT - pulmonary function test
PICC - peripherally inserted central catheter
PO - by mouth
PRN - as needed
PT - physical therapy
PT - prothrombin time
PTSD - post-traumatic stress disorder
PVC - premature ventricular contraction
QD - once a day
QID - four times a day
RA - rheumatoid arthritis
RICE - rest, ice, compression, elevation
RSI - rapid sequence intubation
RSV - respiratory syncytial virus
SBP - systolic blood pressure
SLE - systemic lupus erythematosus
SSRI - selective serotonin reuptake inhibitor
STAT - immediately
TB - tuberculosis
TIA - transient ischemic attack.
TID - three times a day
TKO - to keep open
TNTC - too numerous to count
TPN - total parenteral nutrition
URI - upper respiratory infection
UTI - urinary tract infection
V-fib - ventricular fibrillation
V-tach - ventricular tachycardia
VA - visual acuity
WNL - within normal limits
AED - automated external defibrillator
ARDS - acute respiratory distress syndrome
BID - twice a day
BP - blood pressure
BUN - blood urea nitrogen
CAD - coronary artery disease
CHF - congestive heart failure
CVA - cerebrovascular accident
D/C - discontinue
DKA - diabetic ketoacidosis.
DM - diabetes mellitus
DVT - deep vein thrombosis
EGD - esophagogastroduodenoscopy
ER - emergency room
F - Fahrenheit
Fx - fracture
GI - gastrointestinal
GTT - glucose tolerance test
HCT - hematocrit
Hgb - hemoglobin
HRT - hormone replacement therapy
ICP - intracranial pressure
IDDM - insulin-dependent diabetes mellitus
IBS - irritable bowel syndrome
IM - intramuscular
IV - intravenous
K - potassium
KVO - keep vein open
L&D - labor and delivery
LASIK - laser-assisted in situ keratomileusis.
ROM - range of motion
RT - radiation therapy
Rx - prescription
SCD - sequential compression device
SOB - shortness of breath
STD - sexually transmitted disease
TENS - transcutaneous electrical nerve stimulation
TIA - transient ischemic attack
TSH - thyroid-stimulating hormone
UA - urinalysis
US - ultrasound
UTI - urinary tract infection
VD - venereal disease
VF - ventricular fibrillation
VT - ventricular tachycardia
WBC - white blood cell
XRT - radiation therapy
XR - x-ray
Zn - zinc
Z-pak - azithromycin (antibiotic).
AAA - abdominal aortic aneurysm
ABG - arterial blood gas
ACS - acute coronary syndrome
ADL - activities of daily living
AED - automated external defibrillator
AIDS - acquired immunodeficiency syndrome
ALS - amyotrophic lateral sclerosis
AMA - against medical advice
AML - acute myeloid leukemia
APAP - acetaminophen
ARDS - acute respiratory distress syndrome
ASCVD - atherosclerotic cardiovascular disease
BPH - benign prostatic hyperplasia
BUN - blood urea nitrogen
CABG - coronary artery bypass graft
CBC - complete blood count
CHF - congestive heart failure
COPD - chronic obstructive pulmonary disease
CPAP - continuous positive airway pressure
CRF - chronic renal failure.
CT - computed tomography
CVA - cerebrovascular accident
D&C - dilation and curettage
DVT - deep vein thrombosis
ECG/EKG - electrocardiogram
EEG - electroencephalogram
ESRD - end-stage renal disease
FSH - follicle-stimulating hormone
GERD - gastroesophageal reflux disease
GFR - glomerular filtration rate
HbA1c - glycated hemoglobin
Hct - hematocrit
HIV - human immunodeficiency virus
HPV - human papillomavirus
HTN - hypertension
IBD - inflammatory bowel disease
IBS - irritable bowel syndrome
ICU - intensive care unit
IDDM - insulin-dependent diabetes mellitus
IM - intramuscular.
IV - intravenous
LFT - liver function test
MI - myocardial infarction
MRI - magnetic resonance imaging
MS - multiple sclerosis
NPO - nothing by mouth
NS - normal saline
OCD - obsessive-compulsive disorder
OSA - obstructive sleep apnea
PCOS - polycystic ovary syndrome
PMS - premenstrual syndrome
PPD - purified protein derivative
PSA - prostate-specific antigen
PT - prothrombin time
PTT - partial thromboplastin time
RA - rheumatoid arthritis
RBC - red blood cell
RSV - respiratory syncytial virus
SLE - systemic lupus erythematosus
TB - tuberculosis.
It is important to remember that medical abbreviations can vary based on location and specialty. 
Healthcare professionals should use medical abbreviations with caution and only when they are familiar with their meanings. 
Patients should always communicate any questions or concerns they have about their medications or medical care to their healthcare provider or pharmacist to ensure they receive safe and accurate medical care.
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lacepockets · 1 year ago
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can i ask what meds your guineapig was put on and what they do? i recently found out my guneapig has an enlarged heart too & i hope i can help him
Oh no, I hope you can help your piggy! 😟 Dilated cardiomyopathy is a fairly common problem for them, and it's terrible. They're such wonderful little creatures, and so delicate, so it's really frightening when something is wrong with them. And cardiac problems in general are scary! I earnestly wish you and your piggy the absolute best!!!
Dolly is on a cocktail of three medicines:
Enalapril once per day. This is an ACE (angiotensin converting enzyme) inhibitor. That enzyme is responsible for narrowing blood vessels, so an inhibitor prevents that enzyme from working, so the blood vessels don't get narrowed and it's easier for blood to travel through them. This is a same medication given to humans with the same condition.
Pimobendan twice a day. This is an inodilator, which in simplest terms, lowers blood pressure. When blood pressure is high, it's easier for it to cause damage to vessels and the heart itself, which in DCM (dilated cardiomyopathy) already has a heard enough time pumping. I believe this is a veterinary-only medication, and it's typically given to dogs but works in other animals too.
Furosemide twice a day. This one is a diuretic, which helps clear fluid from places in the body where it shouldn't be, and expels said fluid in urine. When there's fluid around the heart, the heart can't expand and beat properly, so a diuretic helps with that. This is also given to humans.
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covid-safer-hotties · 1 month ago
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Reference preserved in our archive
A preprint from the latest vaccine study in the Prevent-19 trial. Novavax elicits broader, longer lasting, and sequentially increasing protection from past and present strains of covid than Pfizer and Moderna's mRNA vaccines. This is the fourth study in a row showing Novavax's increasing efficacy with additional boosters, something not seen with mRNA covid vaccines. If you can, you should try and get started on a Novavax series. The more doses you can get, the better lasting protection you'll have.
Abstract Background NVX-CoV2373, a recombinant SARS-CoV-2 spike (rS) protein vaccine with Matrix-M™ adjuvant, has been authorized for use in adults and adolescents. PREVENT-19 (NCT04611802/2019nCoV-301), a pivotal phase 3, randomized, placebo-controlled trial demonstrated robust efficacy of a primary, 2-dose series of NVX-CoV2373 against COVID-19. Methods Protocol expansions to PREVENT-19 included enrollment of adolescents (aged 12 to <18 years) and administration of 3rd and 4th doses of NVX-CoV2373 to adults and adolescents. Participants randomized 2:1 received NVX-CoV2373 or placebo 21 days apart; 3rd and 4th doses were administered ≥6 months after the preceding dose. Secondary and additional assessments included post-3rd- and 4th-dose immune responses (neutralizing antibody [nAb], anti-rS IgG, human angiotensin-converting enzyme-2-receptor binding inhibition [hACE2-RBI]) and response durability (post-3rd dose) to ancestral virus; cross-reactivity to Omicron subvariants; safety; and reactogenicity. Results Immune responses were observed against ancestral virus after two doses of NVX-CoV2373 but not after placebo. In both adults and adolescents, additional doses of NVX-CoV2373 increased nAb titers, anti-rS IgG levels, and hACE2-RBI; durable responses were recorded 8 months post 3rd dose. nAb responses post 3rd dose were noninferior to those post primary series. Cross-reactivity to BA.5 and BQ.1.1 variants was also observed, with anti-rS IgG levels post 3rd or 4th dose exceeding previously reported correlates of protection. Additional doses of NVX-CoV2373 were well tolerated, with no new safety signals. Conclusions NVX-CoV2373 elicited robust and durable humoral immune responses to ancestral SARS-CoV 2 as a 3rd and 4th dose after the primary series in adults and adolescents. Cross-reactivity to relevant variants provides insight into potential protection against antigenically related, but shifted, viral strains. Additional doses of NVX-CoV2373 were well tolerated with no new safety signals. These results support the utility of this vaccine platform and continued updates, based on currently circulating strains, to help effectively combat SARS-CoV-2 infection.
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longhaulerbear · 2 years ago
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Gastrointestinal symptoms are common in Coronavirus Disease 2019 (COVID-19), related to infection of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) of intestinal cells through the angiotensin converting enzyme 2 (ACE2) receptor in the brush border. Also, patients are treated with multiple antibiotics. Therefore, an increase in gut dysbiosis and in the prevalence of Clostridium difficile infection (CDI) is expected in patients with COVID-19.
In COVID-19 there is bacterial and fungal dysbiosis that correlates with systemic and pulmonary inflammation, and illness severity. Further investigations are warranted to determine the efficacy of bacteriotherapy and FMT for modulating gut dysbiosis in COVID-19.
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roshankumar7904800 · 5 days ago
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Angiotensin Converting Enzyme (ACE) Inhibitors Market
Angiotensin Converting Enzyme (ACE) Inhibitors Market Size, Share, Trends: Pfizer Inc. Lead
Combination therapies gaining traction for improved cardiovascular outcomes
Market Overview:
The global Angiotensin Converting Enzyme (ACE) Inhibitors Market is projected to grow at a CAGR of 3.5% from 2024 to 2031. The market value is expected to increase from USD XX billion in 2024 to USD YY billion by 2031. North America currently dominates the market, followed closely by Europe. Key metrics include the rising prevalence of cardiovascular diseases, increasing geriatric population, and growing awareness about the importance of blood pressure management. The market is experiencing steady growth due to the expanding indications for ACE inhibitors and their proven efficacy in treating various cardiovascular conditions.
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Market Trends:
The market for ACE inhibitors is shifting significantly towards combination therapy, in which these drugs are used with other cardiovascular medications to improve efficacy and patient outcomes. This trend is being pushed by accumulating evidence demonstrating the synergistic effects of mixing ACE inhibitors with calcium channel blockers or diuretics. Combination medications have various advantages, including better blood pressure control, fewer side effects, and higher patient compliance due to streamlined dose regimens.
Market Segmentation:
Lisinopril dominates the ACE inhibitors market due to its efficacy, long-acting formulation, and broad range of indications. Lisinopril has emerged as the dominant sector in the ACE inhibitors market, accounting for a sizable portion of total market revenue. This dominance can be due to a variety of variables, including its once-daily dosing regimen, demonstrated efficacy in the treatment of hypertension and heart failure, and well-established safety profile.
Recent research have strengthened Lisinopril's market position. For example, studies published in the Journal of the American Heart Association demonstrated the drug's ability to reduce the incidence of recurrent stroke in hypertensive individuals. These data continue to support the widespread usage of Lisinopril in a variety of patient categories.
Market Key Players:
Pfizer Inc.
Novartis AG
Merck & Co., Inc.
AstraZeneca plc
Johnson & Johnson Services, Inc.
Sanofi S.A.
Contact Us:
Name: Hari Krishna
Website: https://aurorawaveintellects.com/
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