#covid vaccines
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culturevulturette ¡ 6 months ago
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This was always the claim. Don't let them gaslight you.
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covid-safer-hotties ¡ 22 days ago
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Also preserved in our archive (Daily updates!)
At a Glance ~Researchers found that current COVID-19 vaccines fail to generate mature and durable antibody-producing cells in the bone marrow. ~The findings could help explain why protection tends to decline over time. ~Better understanding of long-term immune responses could lead to improved vaccines that provide enduring protection.
Some vaccines offer long-lasting protection. For instance, the tetanus vaccine provides protection for at least 10 years. With other vaccines, protection may begin to decline within a few months. To provide enduring immunity, a vaccine must elicit production of long-lived plasma cells, a type of immune cell that matures over time in the bone marrow and can rapidly trigger production of disease-fighting antibodies.
The mRNA vaccines developed for the SARS-CoV-2 virus have proven effective at preventing severe COVID-19 and reducing hospitalizations. These vaccines trigger production of antibodies that home in on the virus’s spike protein. But protective antibodies can begin to fade as soon as three months later and lead to breakthrough infections. Researchers have been puzzled by this waning protection, since SARS-CoV-2-specific immune cells can often be found in the bone marrow.
To better understand why protection against SARS-CoV-2 dwindles months after vaccination, a research team led by Dr. F. Eun-Hyung Lee of Emory University took a closer look at immune cells in the bone marrow of 19 healthy adults. Participants ranged in age from 20 to 65. All had previously received between two and five doses of mRNA COVID-19 vaccines. Samples of their bone marrow were evaluated within 33 months after receiving their initial COVID-19 vaccine shot.
The participants had also received an influenza vaccine within a year of giving their bone marrow samples. And all had previously received tetanus shots and boosters. Their responses to these previous vaccines were used for comparison.
The researchers used a cell-sorting technique called flow cytometry to separate each participant’s bone marrow immune cells into different groupings. These included short-lived antibody-secreting cells and long-lived plasma cells that confer lasting protection. Results appeared in Nature Medicine on September 27, 2024.
The scientists found that they could readily detect long-lived plasma cells that target tetanus and influenza. In contrast, while shorter-lived antibody-secreting cells specific to SARS-CoV-2 were abundant, long-lived ones were mostly absent. Even among five participants who had recent SARS-CoV-2 infections and vaccinations, long-lived plasma cells against the virus were scarce in the bone marrow samples.
The findings hint that newly created antibody-secreting cells against SARS-CoV-2 are unable to become fully mature and long-lasting once they reach and settle into the bone marrow. In contrast, vaccines against tetanus and influenza prompt antibody-producing cells to mature within bone marrow and become long-lived plasma cells. Future studies will need to investigate how to generate long-lived plasma cells against SARS-CoV-2.
“The holy grail of vaccine researchers is the generation of long-lived plasma cells,” Lee says. “Our findings demonstrate that current SARS-CoV-2 mRNA vaccines do not provide such long-lasting protection within bone marrow. Further research is needed to determine if updated vaccines, new delivery schedules, or other factors might provide such protection.”
—by Vicki Contie
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long-anti-covid ¡ 4 months ago
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article date: July 26, 2024
"Historically, when we're talking about COVID vaccines, we're talking about boosters that would happen at some time post your previous vaccine," said Dr. John Brownstein, an epidemiologist and chief innovation officer at Boston Children's Hospital and an ABC News contributor. "Now we're targeting annual vaccines for COVID-19 that is similar to flu. It's a reformulation based on what's circulating, and this is why we're talking about an annual campaign rather than a booster," he continued.
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pandemic-info ¡ 3 months ago
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News on Fall Boosters
(I focus on Novavax for reasons previously discussed on this blog, searchable via its tag.)
June 14, 2024 - Novavax Submits Application to U.S. FDA for Updated Protein-based 2024-2025 Formula COVID-19 Vaccine
Novavax's JN.1 vaccine has demonstrated broad cross-neutralizing antibodies against multiple variant strains, including KP.2 and KP.3, indicating the potential to protect against forward drift variants.
June 27, 2024 - U.S. CDC & ACIP Recommend Use of Authorized and Approved 2024-2025 COVID-19 Vaccines
Today the U.S. Centers for Disease Control and Prevention’s (CDC) Advisory Committee on Immunization Practices (ACIP) voted unanimously in favor of a universal recommendation for the use of 2024-2025 COVID-19 vaccines ... Novavax intends to provide doses of our 2024-2025 COVID-19 vaccine at the start of the vaccination season and upon EUA by the U.S. Food and Drug Administration (FDA).
Aug. 14, 2024 - COVID is surging again. Here’s the latest on new variants, updated vaccines, and masking
Novavax, an American biotechnology company, had already developed a JN.1-targeted vaccine and the company said it wouldn’t have time to change the formulation before the fall. Novavax’s vaccine is the only protein-based COVID-19 vaccine
[I disagree with Mark Sawyer, MD's quote in the article that “It’s important to have Novavax as an option because some people are still concerned about mRNA”. I in particular have no issue with "mRNA tech", have taken it, and am familiar with it due to having worked on some of the earliest science-journalistic reporting about it. Many choose Novavax for other reasons, again, discussed previously / elswhere, and will continue to as long as it confers equal or better protection vs mRNA options.]
Is it time to wear a mask again? ... Sawyer also recommends masking while traveling or in high-risk situations.“ If you’re in a community where the virus is surging, as so many people are, it is smart to wear a mask if you’re in indoor, crowded conditions,” he says.
[*For some of us it isn't "again"; we didn't stop in any situation where it was "smart" to.]
Despite COVID not being a seasonal illness, new vaccines are still being offered on a seasonal schedule. Updated boosters are again expected in September.
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gwydionmisha ¡ 1 year ago
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gumjrop ¡ 2 months ago
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The Weather
As of September 13, 2024, national wastewater levels remain high. The CDC’s national wastewater map has contracted viral activity levels from ten grades of color to five grades of color while our map below maintains the original ten grades of color based on CDC data. We will adjust to the five grades in future reports. With schools in full session and the weather transitioning in northern regions to cooler temperatures, transmission continues to occur. Wastewater activity is either “High” or “Very High” in 37 states according to the Wastewater Surveillance System (NWSS) dashboard. Activity is “Moderate” in 8 states and the District of Columbia, and there is no data available for New Hampshire, North Dakota, Oregon, the U.S. Virgin Islands, and Guam. 
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According to the Wastewater COVID-19 National and Regional Trends dashboard, COVID wastewater levels have plateaued, remaining between high and very high in all regions except for the West, which is having a slight increase. The highest levels remain in the West as of 9/7/2024 (data captured on 9/13/2024). 
In order to access local COVID wastewater levels, you can refer to the CDC’s state/territory trends page as well as the WastewaterSCAN dashboard. State and local public health wastewater trackers may also be available for example in Illinois, they are reporting over 80 locations. Also, the National Academies of Medicine recently published a second report stressing the importance of a robust wastewater surveillance system and its invaluable role in infectious disease surveillance. They recommend improving the consistency and quality of wastewater surveillance for COVID and other infectious diseases.
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As of September 10, 2024, COVID levels are “likely growing” in 3 states and territories according to the CDC Center for Forecasting and Outbreak Analytics dashboard. Thirteen states have reached “stable or uncertain” levels, and 31 states are seeing “declining” or “likely declining”, while levels are “not estimated” in 4 states. 
Note, this model utilizes emergency department visit data to estimate COVID transmission’s Rt, which is an estimate of the average number of new infections caused by each infectious person. An Rt greater than 1.0 indicates that infections are growing, while an Rt less than 1.0 indicates that they’re declining.
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According to the CDC's COVID Data Tracker, there has been an increase to nearly 1,000 deaths and slightly more than 1,000 deaths per week from COVID during the entire month of August 2024. The last time this occurred was during the winter months of 2024. This total count of weekly COVID deaths is likely to be an underestimate due to limited COVID testing and reporting. The loss of these lives could have been prevented if layers of protections were consistently implemented in preventing infections. 
A recent study published in the Annals of Internal Medicine highlights the importance of preventing infections especially during periods of high rates of transmission. It notes that COVID death rates were higher when healthcare systems faced a larger strain as a result of increased levels of transmission. Comprehensive policies that protect people and prevent healthcare-acquired COVID infections are needed to prevent healthcare system overload.
Variants
According to the CDC’s variant tracking dashboard, KP.3.1.1 remains the dominant variant of all currently circulating strains. Nowcast modeling projects that KP.3.1.1 will increase to 52.7% by 9/14/2024, followed by KP.2.3 at 12.2%, followed by LB.1 at 10.9%, and KP.3 at 10.6%, respectively. The most prevalent circulating variants are JN.1-derived, and closely related to both JN.1 and KP.2. Updated vaccination with any of the available options (Pfizer, Moderna, or Novavax) is recommended to better match current variants.
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Vaccines and Treatment
Although the Bridge Access Program, covering the updated vaccines for uninsured and underinsured adults, has ended, several states including California’s Bridge Access Program and other departments of health have taken steps to partially address this major gap by either providing funding for no-cost access to COVID vaccines or using budgets to acquire a limited supply for their residents. Ultimately, the federal government must contribute resources to ensure no-cost access for all who are uninsured or underinsured. We continue to demand from the federal government to provide continued funding for the Bridge Access Program as well as the Vaccines for Adults Program. As people access the updated COVID vaccines, it is notable that a longer 1.5 inch needle may be needed for adults with higher body weights, in order to pass through subcutaneous tissue into muscle. Complete guidelines for vaccine administration in consideration of age, weight, and injection site can be found on the CDC's website.
It is important to seek treatment when facing a COVID infection. A recent study, reviewing population data of nonhospitalized individuals ages 18 and older during the period of January 2022 and December 2023, showed that nirmatrelvir/ritonavir (Paxlovid)—treatment for COVID—was less commonly used among those who identified as non-Hispanic Black and Latinx/e patients. Although the Test-to-Treat program prematurely ended, there continue to be programs available to ensure financial access to Paxlovid.
Wins
This is a reminder that another batch of no-cost COVID rapid antigen tests can be ordered and sent to your home address at the end of September 2024. Through the CDC’s Increasing Community Access to Testing (ICATT) program, no-cost access to COVID testing access is limited to those who are uninsured or underinsured at places including CVS, Walgreens, eTrueNorth, and other local sites as well as in New York City, which is supported by the NY Department of Public Health.
We are eagerly awaiting news on updates from the Centers for Medicare and Medicaid on mandatory reporting of COVID infections in healthcare systems, which begins November 1 thanks to our community’s advocacy. It is invaluable that all healthcare systems participate as case data is paramount for keeping track with current COVID trends and understanding the volume of healthcare acquired COVID infections. 
Take Action
The National Institute of Health (NIH) is seeking public comment and feedback on the next phase of RECOVER clinical trials, which focus on Long COVID. Meetings will be held virtually and on-site between September 23 and 25 to solicit feedback and comments. Register to attend these virtual or on-site sessions by September 25, 2024. It is very important to participate and ask NIH to commit to studies that will result in developing a better understanding of Long COVID, effective treatments for Long COVID, and key approaches to preventing Long COVID. 
Amid ongoing COVID spread, masking in healthcare remains central to safe access to healthcare. As we await implementation of COVID hospitalization reporting and prepare for CDC’s next Healthcare Infection Control Practices Advisory Committee meeting in November, you can use this letter campaign to ask your elected officials to take action for healthcare masking.
And finally, because all of us need access to the updated COVID vaccines regardless of our insurance status or ability to pay, use our letter template to demand free COVID vaccines for uninsured and underinsured adults nationally.
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montmorillionite ¡ 3 months ago
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I went to go get my flu shot and COVID booster today, and successfully got my flu shot.
I'm between insurance at the moment and do you want to know what the COVID booster costs without insurance? $200. Fucking ridiculous. I'm lucky that I get insurance through my job in a couple weeks so I can wait till then but holy fuck. I really feel and worry for anyone who isn't insured at the moment.
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theculturedmarxist ¡ 1 year ago
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There have been many scandals associated with covid in the last nearly 4 years.
I want to tell you about another one that has got zero media coverage.
The top-line is this: the UK government gave more than 2.3 million vulnerable and older people a covid vaccine that isn’t matched to the currently dominant covid strains. And they did it to save money.
The dominant covid strains right now are known as the XBBs. They have been dominant since late summer in most places, when they took over from the BA strains of omicron.
But rather than give people the new more effective XBB vaccine, the British government decided to use up their stockpile of the older BA vaccines first.
The worst thing is, those who got the outdated vaccine were those first in line for vaccines, such as older people and people with health conditions.
But they won’t know this.
So 2.3 million vulnerable people in the UK are walking around thinking they are well-protected this winter against covid when they’re not.
The British government didn’t hide why it did this. On the official government webpage it spells it out. In bold are the clues hiding in plain sight.
“The choice of vaccine products for autumn 2023 has been determined based on available data on vaccine safety, effectiveness and immunogenicity, logistical factors, programmatic deliverability and a bespoke cost effective assessment. Other vaccines which may offer similar protection, but which would incur additional costs, are expected to be less cost effective within the bespoke cost-effectiveness assessment compared to pre-procured Omicron-variant mRNA COVID-19 vaccines.”
What they are saying, under the cover of the gross language of ‘bespoke cost effectiveness assessment,’ is that they’d already bought the older vaccines and it was cheaper to use them than buy extra new ones.
They used people’s bodies as asset dumps for old medical stock.
In the UK the booster roll-out began on September 11th. We know that in Scotland they switched over to XBB on September 25th and in England and Wales they switched to the new ones on October 2nd, as confirmed that day by Meaghan Kall, an epidemiologist at the UK’s health security agency responsible for covid.
But by September 29th the British government reported 2.35 million people had been covid boosted. So we know this was largely with the old vaccine (save 4 days in Scotland). In response to my thread on Twitter, many reported receiving the old vaccine. Even now, people are saying they’re still only being offered the old vaccine.
Boosting people with a vaccine not matched to the dominant strains will certainly lead to worse outcomes as an average than if these people had received the updated vaccine. People will die for this penny pinching.
But then the British government has for some time now been relaxed about killing people for austerity.
The Brits are also tightly restricting access to covid vaccines, in contrast to almost every other country. And in a final twist, the Brits are now stockpiling the new XBB vaccines and are almost certainly going to take the same approach to deploying an outdated vaccine next time round.
When I tweeted about this, the Guardian journalist George Monbiot responded and we subsequently exchanged emails. Monbiot did then write a very good column about the ongoing burden of covid in the UK and the various public health failures.
But the article omitted any mention of the millions who were given the older vaccine.
I can’t criticise Monbiot. I wouldn’t be surprised if he included this and it was cut by his editors. And his article stands head and shoulders above almost any other reporting of covid in the mass media, a mass media that has played a key part in normalising the transmission of a virus that has become the leading cause of infectious disease death in the world today.
These lies and misinformation about covid in the mass media continue. Last week was no exception.
The BBC’s health editor Nick Triggle wrote a truly noxious covid story full of half-truths, lies by omission and propaganda. He said covid was less deadly than the flu, that it is becoming a seasonal ‘bug’, that people who were concerned about rising hospitalisations were just anxious. (Nick Triggle’s sister-in-law is a Tory member of parliament, which might explain some things).
In the US, the New York Times interviewed the epidemiologist and long-time covid downplayer Michael Mina who said rates of long covid are drastically falling - without citing a shred of evidence - and said repeated exposure to covid for most people will not be harmful and will build immunity. In the comments below the piece, one person said the “excellent story begs the question as to whether healthy people should take any precautions against covid.” Job done.
Then there was the ‘long cold’ research paper which was amplified across global media.
If you missed it, the thrust was that long colds might be as common as long covid. So far, so fine.
But the findings were stripped of critical context in relation to covid.
It failed to acknowledge that even if long colds do exist, and almost certainly they do, Sars-Cov-2 is a different beast, behaving in a completely different way to other common cold-causing coronaviruses.
And rather than the conclusion here being ‘ok, so if long colds are this common, long covid might be very common too and maybe we should do something about it,’ the stories led us towards the conclusion that long covid itself is nothing to worry about because post-viral illness is nothing new.
All of this would have been bad enough without mentioning the methodology.
The study was conducted in 2020-2021 and relied on people self reporting a respiratory illness that they said wasn’t covid. We know for a fact that far fewer people got a respiratory illness that wasn’t covid in these years, so I expect a good number of these ‘not covids’ leading to ‘long colds’ were, in fact, covids leading to long covid. But again, the media stories failed to provide any of this context. Nick Triggle was one of those who wrote a story.
Triggled twice in two weeks.
Over and over, it seems that those who are concerned about covid come armed with data, and those who aren’t come armed with gut feeling in order to keep business-as-usual ticking over.
It’s 2019 again! Stop worrying!
Normalisation is the most powerful sociological force in the world today. Through a captured media, the ruling class can make us absorb a pandemic, accept climate collapse and shrug at apartheid. Change is unnecessary because nothing is wrong. It is just the natural order, flowing.
We also found out this week that just 2% of Americans have stepped up for the new covid jab, a rate of uptake that can be traced back to the early over-hyping of vaccines and the manufacturing of a narrative that says covid is mild and we’ve all achieved immunity now anyway.
I didn’t know where we’d be nearly four years on from the start of the pandemic, but I didn’t think we’d be here. New waves, millions being infected, thousands dying every week. And a media and public knowledge blackout of Novavax, the most effective vaccine. A vaccine we’ve known is the most effective for over two years.
It is tiring to keep up, to keep bearing witness to these fuck-ups, to this cruelty.
But we have to.
Because to believe in change means documenting the incompetence, the failure, the lies and the indifference that eventually compels that change to come.
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nowstomorrow ¡ 1 year ago
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"What about people who had mRNA doses previously but want to consider Novavax? There have been several studies now that found mixing the two, getting mRNA and then Novavax actually gave better results than just mRNA on its own.
One study found that getting Novavax as a booster after mRNA "may enhance the persistence and durability of vaccine-mediated immunity compared to mRNA options" with slower decay rate compared to an mRNA booster dose and less side effects than mRNA boosters.
A randomized controlled trial found that getting a Novavax dose after Pfizer mRNA elicited the highest humoral and peak cellular immune responses.
The mRNA + Novavax combination also had the lowest rate of breakthrough infections and the study also found fewer moderate and severe systemic adverse effects for Novavax than Pfizer mRNA.
Neutralising antibodies against Omicron BA.1 and BA.2 were higher with Novavax after mRNA compared to two mRNA doses."
- sources and graphs at the link:
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vizthedatum ¡ 5 months ago
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This is a brief vent and tangential aside about the healthcare hype surrounding naming some of the current trending and contagious COVID-19 variants, the "FLiRT" variants (of course, please stay safe this summer (2024) with COVID-19).
Linking my Substack article about this, which gets updated with corrections
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Here are some highlights of this post (the TLDR):
- It's a vent about naming the FLiRT COVID-19 variants (a well-known stereotype that scientists like to make acronyms or catchy names).
- It's an explanation of how the naming FLiRT came to be.
- I'm bothered and irked because, in an attempt to distinguish variants, "FLiRT" doesn't. Additionally, it makes light of an ongoing pandemic.
- I really am not critiquing the person or people who came up with the name; I'm more upset about the name (and its playful connotations) catching on in the media and becoming a part of our ever-growing COVID-19 zeitgeist.
- I added some very brief (potentially useful?) insight at the end of my vent about how vaccine development should focus more on KP.2 and KP.3's F456L mutation rather than the JN.1 strain.
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liberty1776 ¡ 9 months ago
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With people suddenly dropping dead all over the mRNA-vaccinated world, with oncologists reporting massive increases in cancers, turbo-cancers never previously encountered, with studies documenting menstrual and fertility problems with Covid-vaccinated women, with young children having heart attacks, with a new form of blood clots that look like linguine, with outbreaks of Guillain-Barre syndrome and neurological ailments, myocarditis, pericarditis, spinal cord and brain inflammations, and every other kind of health horror, a controlled narrative explanation is needed.  Big Pharma is dealing with the problem by rounding up a collection of its grant-bribed medical researches to admit the problem but to trivialize  it … Continue reading →
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covid-safer-hotties ¡ 2 months ago
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Reference archived on our website
Another study showing the lack of lasting covid immunity from mRNA vaccination. 2 main takeaways: if you get mRNA, keep boosted, and if you can get novavax or another protein-based vaccine, get it. Studies on protein covid vaccines show much higher lasting immune effects even if their antibody titres aren't quite as high as the mRNA peaks (which very rapidly drop as shown in this study among others).
Highlights • These are the first phase four randomised trial data of the immunogenicity, reactogenicity and safety of second booster (fourth doses) of mRNA and protein subunit COVID-19 vaccines in adults previously primed with two doses of AZD1222. • BNT162b2, mRNA-1273 and NVX-CoV2372 were well tolerated and boosted humoral immune responses until Day 84. • Higher binding and neutralising antibodies against Ancestral SARS-CoV-2 were observed following boosting with mRNA vaccines (BNT162b2 and mRNA-1273) compared to NVX-CoV2372 at all time points. • Lower neutralising antibody responses were observed against Omicron subvariants BA.5 and XBB.1.5 following all vaccines until Day 84 highlighting the need for boosting with vaccines with greater specificity for Omicron subvariants.
Abstract Objectives PICOBOO is a randomised, adaptive trial evaluating the immunogenicity, reactogenicity, and safety of COVID-19 booster strategies. We report data for second boosters among individuals 50-<70 years old primed with AZD1222 (50-<70y-AZD1222) until Day 84.
Methods Contributed equally as first authors.Immunocompetent adults who received any first booster >three months prior were eligible. Participants were randomly allocated to BNT162b2, mRNA-1273 or NVX-CoV2373 1:1:1. The concentrations of ancestral anti-spike immunoglobulin was summarised as the geometric mean concentrations (GMC). Reactogenicity and safety outcomes were captured. Additional analyses including neutralising antibodies were performed on a subset. ACTRN12622000238774.
Results Between Mar 2022-Aug 2023, 743 participants were recruited and had D28 samples; 155 belonged to the 50-<70y-AZD1222 stratum. The mean adjusted GMCs (95% credible intervals) were 20,690 (17,555-23,883), 23,867 (20,144-27,604) and 8,654 (7,267-9,962) U/mL at D28 following boosting with BNT162b2, mRNA-1273 and NVX-CoV2372, respectively, and 10,976 (8,826-13,196), 15,779 (12,512-19,070) and 6,559 (5 220-7 937) U/mL by D84. IgG against Omicron BA.5 was 2.7–2.9 times lower than the ancestral strain. Limited neutralisation against Omicron subvariants was found following all vaccines. Severe reactogenicity events were <4%.
Conclusions All vaccines were immunogenic with more rapid waning after mRNA vaccines. These data support boosting with vaccines with greater specificity for circulating Omicron subvariants.
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liesmyteachertoldme ¡ 2 years ago
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Former NFL linebacker dies suddenly at 25, no cause of death given. NFL currently touts a 95% player vaccination rate. Jessie Lemonier was just one day from turning 26.
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bernie-buddy ¡ 10 months ago
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So the "Florida Surgeon General" just called for a halt in Covid vaccines, citing one (1) paper.
Being skeptical of anything involving Ron DeSantis, I went to actually read the paper.
Just one problem, I don't understand any of this.
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If anyone can decipher this paper and make it readable, be my guest:
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uboat53 ¡ 2 years ago
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You know, I think we're at the point now where Covid-19 vaccine mandates aren't necessary in most places, but places that care for the elderly are most definitely one of the exceptions to that.
Yes, to most people Covid-19's risk is fairly low (though higher than I think we'd be comfortable with if we did the math), but people over 65 are definitely not in that category.
Places like nursing homes and health care facilities that primarily cater to the elderly should still have Covid-19 vaccine mandates (and probably flu vaccine mandates as well). No one wants grandma to die because someone who was supposed to take care of her gave her a deadly virus instead.
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gwydionmisha ¡ 1 year ago
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I always ask them to do my left as a matter of course. I now feel lucky.
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