#Stem cell treatment for autoimmune

[healthcareinformations]

Stem cell treatment for autoimmune in India gives a promising road for patients looking for an opportunity to standard treatment options. Visit us https://bit.ly/3BhLOO1

[kellumstemcellinstitute]

Navigating the IV Route: Advancements in Depression Treatment

Navigating the IV route in depression treatment opens new doors for individuals who have struggled to find relief through traditional methods. From ketamine infusion therapy to personalized treatment approaches, advancements in IV therapies offer hope and promise for those living with treatment-resistant depression. For more details, visit our website.

[wheelie-sick]

What is immunocompromisation?

Being immunocompromised means you have a weaker immune system than most people. There are two main ways people become immunocompromised

1. Medical Conditions

Certain medical conditions cause your immune system to be weaker. Some examples include:

Immunodeficiencies- A category of conditions causing a lower number of or lower efficacy of immune cells. This category is divided into two subcategories: primary immunodeficiency and secondary immunodeficiency. Primary immunodeficiency is a subcategory consisting of hundreds of different conditions all causing a lower number of immune cells. Secondary immunodeficiency is a smaller category consisting of conditions where a person lacks immune cells due to other causes such as malnutrition.

HIV/AIDS

Some cancers

2. Medications

There are two main types of medications that result in being immunocompromised: Immunosuppressants and chemotherapy

Immunosuppressive medications- Immunosuppressive medications are medications designed to suppress your immune response. These can work in many different ways with some targeting a broad range of immune cells and others being highly specific. These medications are often used for organ transplant recipients and people with moderate-severe autoimmune diseases. Some medications in this category include: organ transplant medications, biologics, and high dose corticosteroids

Chemotherapy- Chemotherapy often comes with the effect of preventing new fast-dividing cells from being produced. This is why hair loss is such a common side effect of chemotherapy. Immune cells are fast dividing and therefore frequently are unable to be produced while on chemotherapy

The effects of immunocompromisation

Immunocompromisation has a large range of effects depending on the reason someone is immunocompromised. The most common effects are an increased susceptibility to illness and cancers. Increased susceptibility to illness can look like:

Frequent illnesses

Illnesses that are more severe than they would be for other people

Recurrent infections

Infections that don't respond to medication

Delayed response to infection

Infections that last longer than usual

Some people are more susceptible to certain types of infections. For example anifrolumab, a biologic used for lupus, makes people more susceptible to herpes zoster and respiratory tract infections while prednisone, a corticosteroid, increases risk of infection across the board. This occurs due to different causes of immunocompromisation affecting different immune cells with different roles in preventing and responding to infection.

Grades of severity

Recently the term "moderately and severely immunocompromised" has been used in covid-19 resources. Certain factors are considered to make someone moderately or severely immunocompromised, these include:

Advanced or untreated HIV infection

Moderate or severe primary immunodeficiencies

Hematologic malignancies

Active treatment for solid tumors or hematologic malignancies

Immunosuppressant medications used for solid organ or islet transplants

CAR-T cell therapy or hematopoietic stem cell transplantation

Treatment with alkylating agents, antimetabolites, high-dose corticosteroids, chemotherapeutic agents, TNF blockers, and other biologic agents that are immunosuppressive or immunomodulatory

What immunocompromisation is not

It's worth noting that getting sick frequently or getting seriously sick from illnesses that are usually mild is a warning sign for being immunocompromised but does not inherently make you immunocompromised. Some people are just more susceptible to illness without being immunocompromised.

Having minimal response to an infection that is usually more serious is a sign of a strong immune system, not a weak one.

Being immunocompromised is also not the same as being high risk for serious infection. All immunocompromised people are high risk but not all high risk people are immunocompromised. Immunocompromisation is specifically when someone is high risk because their immune system is weak. Particularly in regards to covid, there are many conditions that make you higher risk that do not involve a weak immune system.

Autoimmune diseases do not automatically make you immunocompromised. Something being a disorder of the immune system does not mean that you are immunocompromised because immunocompromised means a weaker immune system not a malfunctioning immune system.

[kira-akira]

Bernie Sanders Introduces Long COVID Moonshot Legislation

This legislation "provides $1 billion in mandatory funding per year for 10 years to the National Institutes of Health (NIH) to support Long COVID research, the urgent pursuit of treatments, and the expansion of care for patients across the country." Announcement on Sander's twitter and the Long COVID Moonshot website.

This announcement references the number 22 million for adults affected by Long COVID in the US but that number is certainly much higher; in 2022 the CDC reported that 7.5% of US adults have Long COVID and that number can only have increased.

Here is an article published today on PBS if you need a primer or a refresher on what Long COVID is and why everyone needs to care about it. From the article:

"Long COVID is a complex chronic condition that can result in more than 200 health effects across multiple body systems. These include:

Heart disease

Neurologic problems such as cognitive impairment, strokes and dysautonomia. This is a category of disorders that affect the body’s autonomic nervous system – nerves that regulate most of the body’s vital mechanisms such as blood pressure, heart rate and temperature.

Post-exertional malaise, a state of severe exhaustion that may happen after even minor activity — often leaving the patient unable to function for hours, days or weeks

Gastrointestinal disorders

Kidney disease

Metabolic disorders such as diabetes and hyperlipidemia, or a rise in bad cholesterol

Immune dysfunction"

I know it's easy to give into despair but THERE IS HOPE for the future! For decreasing transmission of COVID-19, for developing preventatives against Long COVID, and for treating Long COVID. To highlight just a few of the possible pathways to prevention and treatment being currently researched:

The possibility of using antivirals to treat not just Long COVID but any autoimmune disease

The development of N95 masks that can sense SARS-CoV-2 in exhaled breath using a printed immunosensor

A nasal vaccine that halts transmission of SARS-CoV-2 (though does not stop the user from developing COVID-19)

A Japanese research team is looking to treat COVID-19 by using embryonic stem cells to target the virus

The possibility of using already-developed arthritis drugs to treat Long COVID respiratory symptoms

Researchers just identified a possible protein to target in treating Long COVID fatigue

This is an incredibly small collection of studies researching potential treatments but they themselves and the decades of research they are built on had to be funded. In fact, since the pandemic began, more than 24,000 scientific publications about COVID-19 have been published, making it the most researched health condition in any four years of recorded human history.

So there is hope! But all this research needs money. Money that Long COVID Moonshot will provide. And while we wait for research to bear fruit, that $1 billion per year will also be crucial in caring for those suffering from Long COVID in the meantime.

So What Can You Do?

Keep masking - We've just hit 900,000 new COVID cases per day in the US and this wave is not even at its peak yet (For reference, Fauci stated back in 2021 that getting under 10,000 cases per day would allow for mask mandates and safety measures to relax...)

Go on the Long COVID Moonshot website and write to your legislators in support (You can use their script, it only takes 1 minute!)

Keep yourselves and others informed - On the Moonshot website they also offer handy graphics and facts sheets that you can post wherever you can. Spread the word!

And if you or someone you know has Long COVID, you can write in to the Long COVID Moonshot website about your experience

And remember, no one is safe from Long COVID; your chances of developing Long COVID increase with every reinfection. Until research like what Long COVID Moonshot will fund discovers viable preventatives and treatments, the only way to not get Long COVID is to not get COVID-19 in the first place.

Stay safe, stay hopeful, support Long COVID Moonshot, and mask up!

[contentment-of-cats]

Washington Post:

Scientists found a major clue why 4 of 5 autoimmune patients are women By Mark Johnson and Sabrina Malhi February 1, 2024 at 11:02 a.m. EST

An international team led by scientists at Stanford University has discovered a probable explanation for a decades-old biological mystery: why vastly more women than men suffer from autoimmune diseases such as lupus and rheumatoid arthritis.

Women account for about 80 percent of the people afflicted with autoimmune diseases, a collection of more than 100 ailments that burden a combined 50 million Americans, according to the nonprofit Autoimmune Association. In simple terms, these illnesses manipulate the body’s immune system to attack healthy tissue.

In a paper published Thursday in the journal Cell, researchers present new evidence that a molecule called Xist — pronounced like the word “exist” and found only in women — is a major culprit in these diseases.

Better understanding of this molecule could lead to new tests that catch autoimmune diseases sooner and, in the longer term, to new and more effective treatments, researchers said.

Women typically have two X chromosomes, while men usually have an X and a Y. Chromosomes are tight bundles of genetic material that carry instructions for making proteins. Xist plays a crucial role by inactivating one of the X chromosomes in women, averting what would otherwise be a disastrous overproduction of proteins.

However, the research team found that in the process Xist also generates strange molecular complexes linked to many autoimmune diseases.

Although scientists conducted much of their work in mice, they made an intriguing discovery involving human patients: The Xist complexes ― long strands of RNA entangled with DNA and proteins ― trigger a chemical response in people that is a hallmark of autoimmune diseases.

Discovery of the role played by the Xist molecule does not explain how men get these diseases, or why a few autoimmune diseases, such as Type 1 diabetes, have a higher incidence among men.

“Clearly there’s got to be more, because one-tenth of lupus patients are men,” said David Karp, chief of the division of rheumatic diseases at the UT Southwestern Medical Center in Dallas. “So it’s not the only answer, but it’s a very interesting piece of the puzzle.”

A tale of two X’s

An illustration shows one of the two X chromosomes typically found in women being disabled to ensure the right levels of protein production. (Emily Moskal/Stanford Medicine) Autoimmune diseases have long proved difficult to address. Treatments are limited, and many of the diseases are chronic, requiring lifelong management. Most have no cure, leaving millions of Americans hoping that science will eventually offer better explanations for these ailments.

Stephanie Buxhoeveden was 25 when she began experiencing vision problems in her left eye and found herself unable to hold a syringe in her left hand — a critical tool for her nursing job. The reason: multiple sclerosis, an autoimmune condition in which the immune system attacks the protective covering of the brain, spinal cord and optic nerves.

“I was overwhelmed and scared because I knew there was no cure,” the Virginia resident said. “All of these things that I had laid out, planned and worked really hard for all of a sudden were completely up in the air and no longer guaranteed.”

Previous theories had suggested that the gender imbalance in these diseases might be caused by the main female hormones, estrogen and progesterone, or by the mere presence of a second X chromosome.

A tantalizing clue stemmed from men who have two X chromosomes and one Y chromosome, a rare condition called Klinefelter syndrome. These men run a much higher risk of suffering from autoimmune diseases, suggesting that the number of X chromosomes plays an important role.

Howard Y. Chang, senior author on the Cell paper and professor of dermatology and genetics at Stanford, said he began thinking about the ideas that led to the new discovery when he identified more than 100 proteins that either bind directly to Xist or to other proteins that bind to Xist. Looking at those collaborator proteins, he noticed that many had been linked to autoimmune diseases.

Chang and his team engineered male mice that produced Xist to test whether males that made the molecule would also have higher rates of autoimmune diseases.

Since Xist by itself is not sufficient to cause an autoimmune disease, the scientists used an environmental trigger to induce a lupus-like disease in these mice. They observed that male mice then produced Xist at levels close to those of regular female mice, and well above those of regular male mice.

In humans, genetics and environmental factors, such as a viral or bacterial infection, can also help trigger autoimmune diseases.

The scientists obtained serums from human patients with dermatomyositis, a rare autoimmune disease that causes muscle weakness and skin rash. Serum is the part of the blood that contains antibodies that fight disease. They found that in these patients, Xist complexes produce what are called autoantibodies. Instead of defending the body from invaders, as an antibody would, the autoantibody targets features of the body.

Inactivation of the second X chromosome remains an important process “that you don’t necessarily want to get rid of or tinker with too much,” said Karp of UT Southwestern.

“But this work takes it in a totally different direction, and says that the mechanism that is needed to turn off the second X chromosome, that mechanism in itself might be responsible for generating autoimmunity,” Karp said.

A better understanding of the mechanisms in these diseases would be significant if researchers can use it to develop new diagnostic tools, he added: “We are still using laboratory tests that were developed in the 1940s and ’50s and ’60s because they were easy to do, and they detected the most robust autoimmune responses.”

A long road to new treatments

Jeffrey A. Sparks, an associate physician and director of immuno-oncology and autoimmunity at Brigham and Women’s Hospital who was not involved in the study, said that it will be interesting to see how the treatment options available now might fit into this newfound mechanism.

“The sky’s the limit here,” Sparks said, adding, “I think once you understand the fundamental mechanisms, you could think about developing therapies, early detection and preventions.”

Major advances in treatment, though, may be years away, according to Keith B. Elkon, an adjunct professor of immunology and associate director at the Center for Innate Immunity and Immune Diseases at the University of Washington.

Still, he said, scientific breakthroughs in the past 20 years have prolonged the lives of many people with autoimmune conditions.

“In 1950, if you’ve got a diagnosis of lupus, it would have been as bad as getting a diagnosis of cancer,” Elkon said. “But over the last 15, 20 years there’ve been really striking breakthroughs in understanding disease. It’s at the cusp of now being manageable.”

Buxhoeveden, who is now 36 and a PhD candidate in nursing, is using immunosuppressants to manage her MS. She said she was encouraged by the fact that “we’ve made progress like this study to better understand what it is that triggers it.”

[drshiping]

Stem cell therapy is a form of regenerative medicine that uses stem cells to repair, replace, or regenerate damaged or diseased tissues in the body. Stem cells have the unique ability to develop into different types of cells, making them a powerful tool for treating a wide range of medical conditions.

Applications of Stem Cell Therapy:

1. Bone Marrow Transplants:

• The most established form of stem cell therapy.

• Used to treat blood-related conditions like leukemia, lymphoma, and anemia.

2. Orthopedic Treatments:

• Used to repair or regenerate damaged cartilage, tendons, and bones, particularly in cases of arthritis, sports injuries, and degenerative joint diseases.

3. Cardiovascular Diseases:

• Experimental treatments aim to repair damaged heart tissue after a heart attack using stem cells.

4. Neurological Disorders:

• Research is ongoing to treat conditions like Parkinson’s disease, spinal cord injuries, and stroke using stem cells to regenerate neural tissue.

5. Diabetes:

• Potential to regenerate insulin-producing cells in the pancreas, offering a possible cure for Type 1 diabetes.

6. Autoimmune Diseases:

• Stem cells are being explored for treating conditions like multiple sclerosis and lupus by resetting the immune system.

[lightofraye]

For the previous anon. Listen okay? Very carefully I know it can be hard to you with one or two brain cells but I believe in you you can do this.( Just take a nap after reading that okay? I don't want you to lose your last brain cells)

Being a bully, try to humiliate, fat, ugly....and much more. When you will learn to talk to people about your opinions without using those words? Even that little rabbit knew human matters. "If you don't say nice things don't say it at all." Easy. Believe me that would be so much easier for you to continue your life. Why are you even here if you don't want to read those things? Hm? Just to be a Karen?

If someone is fat they can do diet exercise etc.

If they are ugly( for who actually but let's keep going your way) change their appearance with surgery or do makeup.there are so many ways to cover up those tiny little things. What's going to cover up your bully,(childish) black heart and mind?

Before writing something to someone think about their feelings.( I did and I think you deserved your own treatment.)

Hi anon!

HA! Ahem. Thank you for your support. I appreciate it.

Though, gently, if someone is overweight, it may be exercise and/or diet may not fix the problem. (I know many a person who have weight issues that stem from autoimmune disorders and other health issues that, even with medical treatment and doctors, cannot lose weight. Let's remember that, hmm?)

And yes. If they are "ugly", surgery may fix it. Or maybe there's no need--because they may just be happy and confident in themselves and that shines through every smile and every kind word.

The only true ugliness comes from actions--of abusing someone, of ignoring pain, of ignoring those in need.

Or, in the case of that anon, ugly attacks.

[amins90]

Curing Diabetes Permanently

Curing Diabetes Permanently: Is It Possible?

Diabetes is a chronic disease that affects millions of people worldwide. It is characterized by high levels of sugar in the blood, which can lead to serious health complications if left untreated. While there are various treatments available to manage diabetes, many people wonder if it is possible to cure it permanently. In this article, we will explore this question and provide some insights into the potential for a permanent cure for diabetes.

Understanding Diabetes

Before we dive into the possibility of a permanent cure, it is important to understand what diabetes is and how it affects the body. There are two main types of diabetes: type 1 and type 2. Type 1 diabetes is an autoimmune disease where the body's immune system attacks and destroys the cells in the pancreas that produce insulin. Insulin is a hormone that helps regulate blood sugar levels. Type 2 diabetes, on the other hand, is a metabolic disorder where the body becomes resistant to insulin or does not produce enough of it. Both types of diabetes can lead to high blood sugar levels, which can cause damage to organs and tissues over time.

Current Treatments for Diabetes

Currently, there is no known cure for diabetes. However, there are various treatments available to manage the disease and keep blood sugar levels under control. These treatments include insulin injections, oral medications, and lifestyle changes such as diet and exercise. While these treatments can help manage diabetes, they do not provide a permanent cure.

Research on a Permanent Cure

Over the years, there have been numerous studies and research conducted on finding a permanent cure for diabetes. Some of these studies have shown promising results, while others have not been as successful. One of the most promising areas of research is the use of stem cells to regenerate the damaged cells in the pancreas that produce insulin. This approach has shown some success in animal studies, but more research is needed before it can be used in humans.

Another area of research is the development of a vaccine that can prevent type 1 diabetes. This vaccine would work by stopping the immune system from attacking the cells in the pancreas. While this approach is still in the early stages of research, it shows potential for preventing type 1 diabetes in the future.

Lifestyle Changes

While a permanent cure for diabetes may not be available yet, there are steps that individuals can take to manage the disease and potentially reverse its effects. Making lifestyle changes such as following a healthy diet, exercising regularly, and maintaining a healthy weight can help control blood sugar levels and reduce the risk of complications. These changes can also improve overall health and well-being.

Conclusion

In conclusion, while there is currently no known permanent cure for diabetes, there is ongoing research and promising developments in the field. In the meantime, individuals can manage the disease through various treatments and lifestyle changes. It is important to work closely with a healthcare professional to find the best treatment plan for each individual's unique needs. With continued research and advancements, a permanent cure for diabetes may become a reality in the future.

or you can going to : https://managethenow.com/diabetes/

[gastroenterologyugc]

The Next Frontier in Gastroenterology, IBD & Hepatology: Reflections from the 15th World Conference

The 15th World Gastroenterology, IBD & Hepatology Conference has set the stage for transformative progress in digestive health. As the global community of healthcare professionals, researchers, and students gathered to share insights, one theme stood out: the relentless pursuit of innovation and collaboration to overcome the challenges of modern gastroenterology.This year’s conference was not just a meeting of minds—it was a launchpad for the next frontier in understanding and treating gastrointestinal (GI) disorders, inflammatory bowel disease (IBD), and liver diseases.

Exploring the Next Frontier in Gastroenterology

1.      The Role of Artificial Intelligence (AI) in GI Care AI emerged as a game-changer at the conference, with discussions centered on:

AI-Assisted Diagnostics: Tools like machine learning-powered endoscopy for earlier and more accurate detection of GI cancers.

Predictive Analytics: Using AI to forecast disease progression in IBD and tailor personalized treatment plans.

Streamlining Workflow: Automating administrative tasks to allow clinicians to focus on patient care.

2.      Microbiome Research: Unlocking the Gut’s Secrets Presentations highlighted the gut microbiome’s profound impact on health, including:

The microbiome’s role in autoimmune diseases like Crohn’s and ulcerative colitis.

Therapeutic potential of fecal microbiota transplantation (FMT).

Advances in probiotics and prebiotics for gut health.

3.      Innovations in Endoscopy The conference showcased advancements in minimally invasive techniques:

Enhanced imaging technologies, including confocal laser endomicroscopy, to improve diagnostic precision.

Capsule endoscopy for non-invasive exploration of the small intestine.

Robotic and AI-integrated systems for safer and more effective procedures.

4.      Revolutionizing Hepatology Hepatology sessions focused on managing chronic liver diseases, such as:

Non-alcoholic fatty liver disease (NAFLD): Insights into early detection and treatment.

Advances in antiviral therapies for hepatitis B and C.

Emerging liver regeneration therapies using stem cells.

5.      Holistic Management of IBD Inflammatory bowel disease remains a complex challenge. Key takeaways included:

The role of biologics and biosimilars in personalized treatment.

Addressing the mental health impact of chronic GI conditions.

Integrative approaches combining diet, lifestyle, and pharmacological therapies.

Conference Highlights

This year’s conference offered a dynamic blend of knowledge-sharing and practical engagement:

Keynote Addresses: Pioneers in gastroenterology and hepatology shared groundbreaking research, including updates on precision medicine and telemedicine integration.

Interactive Workshops: Hands-on sessions in advanced endoscopic techniques, microbiome analysis, and dietary interventions provided valuable skills.

Abstract Presentations: Emerging researchers presented innovative studies, sparking discussions and future collaborations.

Submit your research for the next conference: https://gastroenterology.utilitarianconferences.com/submit-abstract-abstarct

What This Means for the Future of GI Care

The conference underscored several shifts that will define the future of gastroenterology, IBD, and hepatology:

Personalized Medicine: Precision-based approaches will dominate treatment strategies, reducing trial-and-error in therapies.

Global Collaboration: International efforts to address disparities in GI care will continue to expand access and equity.

Technological Integration: From AI to telemedicine, technology will streamline diagnostics and improve patient outcomes.

Patient-Centered Care: Emphasis on holistic approaches that integrate mental health, nutrition, and lifestyle modifications.

Be Part of the Transformation

As we reflect on the breakthroughs shared at the 15th World Gastroenterology, IBD & Hepatology Conference, it’s clear that the future is bright for GI care. Whether you’re a seasoned professional or a budding researcher, now is the time to contribute to this evolving field.

Register for the Next Conference: https://gastroenterology.utilitarianconferences.com/registration

Final Thoughts

The next frontier in gastroenterology, IBD, and hepatology is not just about innovation but about turning insights into actionable, patient-centered solutions. The 15th World Conference has ignited this transformation, and the journey continues.

Stay at the forefront of GI advancements by joining the conversation and shaping the future of digestive health. For more information, visit the https://gastroenterology.utilitarianconferences.com/

Let’s lead the way in advancing global gastroenterology!

#Gastro2025 #IBDConference #Hepatology2025 #WorldGastroConference #DigestiveHealth #LiverResearch #IBDUpdates #GlobalHealthcare #MedicalConference2025 #GutHealth #Advancementingastro #Dubaiconference #welcomingresearchers #speaknow #makeyourimpact 

[maxnom]

Neurological Disease Models: Pioneering the Future of Brain Research

Neurological diseases, such as Alzheimer’s, Parkinson’s, epilepsy, and multiple sclerosis, represent some of the most complex and challenging conditions to study and treat. These disorders affect the brain and nervous system, disrupting the lives of millions worldwide. To better understand these conditions, researchers rely on neurological disease models, which replicate aspects of these diseases in controlled environments.

These models provide a crucial foundation for uncovering disease mechanisms, testing treatments, and ultimately paving the way for innovative therapies.

What Are Neurological Disease Models?

Neurological disease models are scientific tools designed to mimic the biological, genetic, and pathological features of brain disorders. They allow researchers to study disease progression, identify potential targets for treatment, and evaluate the safety and efficacy of new therapies.

These models fall into three primary categories:

In Vitro Models: Lab-grown cells, such as neurons and glial cells, used to study molecular and cellular mechanisms.

In Vivo Models: Living organisms, often rodents or zebrafish, engineered to display disease-like symptoms.

Computational Models: Simulations that predict disease dynamics using algorithms and mathematical frameworks.

Why Are Neurological Disease Models Important?

The human brain is incredibly complex, and studying it directly is often impractical or impossible. Neurological disease models provide an accessible way to:

Explore Disease Mechanisms:

Models reveal how diseases begin and progress at molecular and cellular levels.

Develop and Test Treatments:

New drugs can be tested for safety and effectiveness in models before human trials.

Discover Biomarkers:

Early detection is critical for many neurological diseases, and models help identify potential diagnostic markers.

Study Rare Conditions:

For less common diseases like ALS or Huntington’s, models provide a platform for targeted research.

Types of Neurological Disease Models

1. Alzheimer’s Disease Models

Transgenic Mice: Engineered to develop amyloid plaques and tau tangles, mirroring human pathology.

3D Brain Organoids: Stem-cell-derived structures replicating human brain regions affected by Alzheimer’s.

2. Parkinson’s Disease Models

Toxin-Based Models: Neurotoxins like MPTP selectively destroy dopamine-producing neurons.

Genetic Models: Animals carrying mutations in genes such as SNCA mimic familial Parkinson’s disease.

3. Epilepsy Models

Chemically Induced Seizures: Substances like kainic acid provoke seizures for studying epilepsy.

Computational Simulations: Map abnormal electrical activity in the brain.

4. Multiple Sclerosis (MS) Models

Autoimmune Models: Experimental autoimmune encephalomyelitis (EAE) mimics inflammation and demyelination seen in MS.

5. Huntington’s Disease Models

Knock-In Models: Animals modified to express mutant huntingtin genes to study motor and cognitive decline.

Innovations in Neurological Disease Models

Recent advancements are transforming the field:

CRISPR-Cas9 Technology:

Enables precise editing of genes to replicate human disease mutations.

Stem Cell-Derived Models:

Patient-derived iPSCs allow personalized studies of disease mechanisms and drug responses.

AI-Powered Computational Models:

Artificial intelligence enhances predictive accuracy in disease simulations.

Organoids and Microfluidics:

3D brain models and lab-on-a-chip systems provide realistic, human-specific disease environments.

Challenges in Neurological Disease Models

While these models are invaluable, they have limitations:

Incomplete Mimicry:

No model fully replicates the complexity of human neurological diseases.

Ethical Concerns:

Using animals and human-derived cells raises ethical considerations.

High Costs:

Developing advanced models, such as organoids or CRISPR-edited systems, requires substantial resources.

Researchers are addressing these challenges through multidisciplinary approaches and technological integration.

Future Directions

The future of neurological disease models is filled with possibilities:

Personalized Models:

Stem-cell-derived models tailored to individual patients will drive precision medicine.

Hybrid Systems:

Combining in vitro, in vivo, and computational models will create more comprehensive research frameworks.

Real-Time Monitoring:

Emerging imaging techniques will enable live tracking of disease processes in models.

High-Throughput Screening:

Automated platforms will accelerate the discovery of new drugs.

Conclusion

Neurological disease models are essential tools for advancing our understanding of brain disorders. By mimicking disease mechanisms and testing potential therapies, these models have already contributed significantly to neuroscience. As technology continues to evolve, these models will play an even greater role in unraveling the complexities of neurological diseases, bringing us closer to effective treatments and improved patient outcomes.

[krispypeachbarbarian]

Exosomes | Regenerative Medicine | Vero Beach, Fl

Vero Beach, Florida, is a hub for wellness, offering a relaxed coastal lifestyle paired with a growing interest in advanced medical treatments. One such cutting-edge therapy gaining significant attention in the area is exosome therapy. With its potential to transform the field of regenerative medicine, exosome therapy offers a non-invasive, innovative approach to healing, anti-aging, and overall health optimization. In this blog post, we’ll explore everything you need to know about exosome therapy in Vero Beach, including how it works, its benefits, and why it’s becoming a popular choice for individuals seeking rejuvenation and relief from various conditions.

What Are Exosomes?

Exosomes Therapy Vero are tiny extracellular vesicles—microscopic particles—that are naturally released by cells into the bloodstream. These vesicles play an essential role in cell communication, carrying proteins, lipids, RNA, and other molecules from one cell to another. Exosomes are critical for regulating many biological processes, including inflammation, tissue repair, and immune responses. Essentially, they are messengers that enable cells to "talk" to each other and work together to maintain the body’s health.

In the field of regenerative medicine, exosomes have garnered significant attention due to their ability to promote healing and regeneration at a cellular level. Derived from stem cells or other specialized cells, exosomes contain a potent mixture of growth factors, cytokines, and other bioactive molecules that can stimulate tissue repair, reduce inflammation, and accelerate recovery from injury or illness.

How Does Exosome Therapy Work?

Exosome therapy involves isolating exosomes from stem cells or other cell types and then introducing them into the body to promote healing and regeneration. The exosomes are typically administered via injection, although they can also be applied topically or intravenously, depending on the condition being treated. Once introduced into the body, the exosomes travel to areas of injury or inflammation and deliver their bioactive cargo to promote healing at a cellular level.

By delivering growth factors and other regenerative molecules directly to damaged tissues, exosomes stimulate the body’s natural healing processes. This approach can help repair damaged tissue, reduce inflammation, and promote the growth of new, healthy cells. Exosome therapy is being used to treat a wide variety of conditions, including chronic pain, joint degeneration, skin aging, and even neurological disorders.

Benefits of Exosome Therapy in Vero Beach

Exosome therapy offers a wide range of benefits, making it an attractive option for individuals looking for effective and non-invasive solutions to a variety of health concerns. Some of the most notable benefits include:

1. Enhanced Regeneration and Tissue Repair

Exosomes Therapy Vero are particularly effective at promoting tissue repair and regeneration. Whether you are recovering from an injury, surgery, or dealing with degenerative conditions, exosome therapy can speed up the healing process. By delivering growth factors directly to the damaged area, exosomes help stimulate the growth of new, healthy cells, facilitating faster recovery.

2. Reduction of Inflammation

Chronic inflammation is at the root of many health conditions, including arthritis, autoimmune diseases, and chronic pain. Exosome therapy has been shown to help reduce inflammation by modulating the immune system and promoting a healthy inflammatory response. This can lead to relief from pain, swelling, and discomfort associated with inflammatory conditions.

3. Non-Invasive and Minimally Invasive Treatment

One of the primary reasons exosome therapy is gaining popularity is that it is non-invasive or minimally invasive. Unlike traditional surgical procedures, which require long recovery times and carry risks, exosome therapy involves simple injections or topical applications that require little to no downtime. This makes it an appealing option for individuals looking for a faster, less invasive alternative to traditional treatments.

4. Anti-Aging and Skin Rejuvenation

Exosome therapy has shown great promise in the field of aesthetics, particularly for skin rejuvenation. As we age, our skin’s ability to repair itself slows down, leading to wrinkles, fine lines, and other signs of aging. Exosomes Therapy Vero can promote collagen production, stimulate skin regeneration, and enhance overall skin health. Many individuals in Vero Beach are turning to exosome therapy to restore their youthful appearance and improve skin texture, tone, and elasticity.

5. Improved Joint Health and Mobility

Exosome therapy has become an increasingly popular treatment for joint pain and degenerative conditions like osteoarthritis. By delivering regenerative molecules to the affected area, exosomes can promote cartilage repair, reduce inflammation, and improve joint function. Many patients experience a reduction in pain and an improvement in mobility, making it an effective option for those suffering from chronic joint conditions.

6. Treatment of Neurological Conditions

Exosome therapy holds promise in the treatment of neurological conditions, such as Alzheimer's disease, Parkinson’s disease, and multiple sclerosis. The regenerative properties of exosomes may help reduce neuroinflammation, promote nerve regeneration, and improve overall brain health. Though research in this area is still ongoing, exosome therapy offers a potentially groundbreaking approach to treating chronic neurological disorders.

7. Enhanced Overall Wellness

Beyond treating specific conditions, exosome therapy can help optimize overall wellness. Exosomes can boost the body’s natural healing abilities, improve energy levels, and promote better health at a cellular level. For individuals in Vero Beach looking to enhance their vitality, manage stress, or improve their general well-being, exosome therapy can be an excellent addition to a holistic health regimen.

Who Can Benefit from Exosome Therapy in Vero Beach?

Exosome therapy is beneficial for a wide range of individuals, from those recovering from injuries or surgeries to those looking to enhance their health and appearance. Common candidates for exosome therapy include:

Athletes and active individuals: Those recovering from sports injuries or seeking enhanced recovery.

Individuals with joint pain or arthritis: For those looking to manage chronic pain and improve joint function.

People experiencing signs of aging: Those seeking non-invasive treatments for skin rejuvenation, wrinkle reduction, and overall skin health.

Patients with neurological conditions: Individuals with conditions such as Parkinson’s disease, Alzheimer’s disease, or multiple sclerosis.

Anyone seeking improved overall health: Those looking for a non-invasive, regenerative therapy to enhance energy levels, immune function, and general wellness.

Exosome Therapy in Vero Beach: Where to Find Treatment

If you’re interested in exosome therapy in Vero Beach, there are several clinics and wellness centers that offer this innovative treatment. Look for experienced professionals who specialize in regenerative medicine and have expertise in administering exosome therapy. Many clinics offer personalized consultations to determine whether exosome therapy is the right option for your specific health needs.

It’s important to research the clinic’s reputation, ensure they use high-quality exosome products, and inquire about the qualifications of the medical professionals administering the therapy. Be sure to ask about the potential benefits, risks, and expected results before committing to treatment.

Conclusion: Unlock the Power of Exosome Therapy in Vero Beach

Exosomes Therapy Vero is revolutionizing the world of regenerative medicine, offering a promising solution for a variety of health concerns. Whether you’re recovering from an injury, managing chronic pain, or looking for a way to rejuvenate your skin, exosome therapy can provide a safe, effective, and minimally invasive alternative to traditional treatments. With its potential to promote healing, reduce inflammation, and enhance overall wellness, exosome therapy is becoming an increasingly popular choice for individuals in Vero Beach seeking to improve their health and quality of life.

If you’re considering exosome therapy, consult with a reputable provider in Vero Beach to learn more about how this groundbreaking treatment can help you achieve your health and wellness goals.

[rockymountainregenerative]

Effective Treatments for Pain Relief: ESWT and Stem Cell Infusion

Pain relief treatments have evolved significantly over the years, offering patients new hope for recovery. Among the most innovative treatments available today are ESWT treatment and stem cell IV infusion, both of which offer promising solutions for those suffering from chronic pain or injuries. These treatments focus on stimulating the body’s natural healing processes to address underlying issues and provide long-term relief.

What is ESWT Treatment? ESWT treatment, or Extracorporeal Shock Wave Therapy, is a non-invasive procedure designed to treat musculoskeletal conditions such as tendonitis, plantar fasciitis, and calcific shoulder tendinopathy. The treatment works by applying high-energy sound waves to the affected area, stimulating blood flow and accelerating tissue repair. This therapy is often recommended for patients who have not found relief through traditional methods like physical therapy or medication.

The key benefit of ESWT treatment is its ability to promote healing without the need for surgery or invasive procedures. Shockwaves penetrate deep into the tissue, encouraging cellular regeneration and improving the body’s natural ability to repair itself. As a result, many patients experience significant pain relief and improved mobility.

How Stem Cell IV Infusion Helps in Healing Another innovative treatment option gaining popularity is stem cell IV infusion. This method involves injecting stem cells into the bloodstream through an intravenous (IV) line. Stem cells are powerful cells with the ability to differentiate into various types of tissues, such as cartilage, muscle, and bone. By introducing stem cells into the body, the treatment aims to promote the repair of damaged tissues and reduce inflammation, ultimately improving overall function.

The primary advantage of stem cell IV infusion is its potential to treat a wide range of conditions, from joint pain to autoimmune disorders. Since stem cells can regenerate damaged tissues, they have the ability to provide relief from chronic pain and promote faster recovery. This treatment is becoming increasingly popular for conditions such as osteoarthritis, degenerative disc disease, and even sports-related injuries.

Benefits of ESWT and Stem Cell Infusion Both ESWT treatment and stem cell IV infusion offer numerous benefits for patients seeking alternative methods of pain relief. These treatments are not only effective in reducing pain but also help improve mobility and restore function in the affected areas. Additionally, both methods are minimally invasive, which means patients can avoid the risks and recovery time associated with surgery.

For individuals who have struggled with long-term pain or have not found success with conventional therapies, these advanced treatments offer a fresh approach. Whether it’s using shockwaves to stimulate healing or leveraging the regenerative power of stem cells, patients are experiencing enhanced outcomes and faster recovery times.

When to Consider These Treatments Patients dealing with chronic pain, injuries, or degenerative conditions may find ESWT treatment and stem cell IV infusion to be viable options when traditional therapies fail. A consultation with a medical professional will help determine if these treatments are suitable based on individual health needs and the specific condition being treated.

For those interested in non-invasive, natural approaches to pain relief, both ESWT treatment and stem cell therapies represent groundbreaking options that have the potential to significantly improve quality of life.

Conclusion In conclusion, ESWT treatment and stem cell IV infusion are two of the most promising therapies in modern medicine, offering hope to those suffering from chronic pain and injuries. With their ability to accelerate healing and promote tissue regeneration, these treatments can help patients find relief and return to their daily activities without the need for surgery.

[eternahealth3]

Understanding Stem Cell Therapy: Revolutionizing Regenerative Medicine

In the realm of modern healthcare, few advancements have garnered as much attention as stem cell therapy. With its transformative potential to treat chronic conditions, repair damaged tissues, and even combat degenerative diseases, stem cell therapy is paving the way for a new era in medicine. Let’s delve into what stem cell therapy entails, its applications, and how it is reshaping regenerative medicine globally.

What Is Stem Cell Therapy?

Stem cell therapy is a groundbreaking medical approach that uses the body’s building blocks — stem cells — to promote repair and regeneration. Stem cells are unique because they have the ability to develop into different types of cells, such as muscle cells, nerve cells, and blood cells. This capability makes them invaluable for repairing damaged tissues and addressing various health concerns.

Unlike traditional treatments that often focus on managing symptoms, stem cell therapy aims to address the root cause of the problem. By stimulating the body’s natural healing processes, stem cell therapy provides a more sustainable and effective solution for patients struggling with chronic pain, autoimmune diseases, and other debilitating conditions.

The Science Behind Stem Cell Therapy

At its core, stem cell therapy involves extracting stem cells from the patient’s body or a donor source and reintroducing them into areas requiring repair. Common sources of stem cells include bone marrow, adipose (fat) tissue, and umbilical cord blood. Once harvested, these cells can be cultured and manipulated in a lab to enhance their regenerative properties.

When injected into the targeted area, stem cells help reduce inflammation, promote tissue repair, and stimulate the growth of healthy cells. This process not only accelerates recovery but also reduces the risk of complications associated with invasive procedures or prolonged medication use.

Applications of Stem Cell Therapy

Stem cell therapy has shown remarkable promise across a wide range of medical applications. Some of the most notable areas include:

Orthopaedic Conditions: Patients suffering from osteoarthritis, joint pain, or ligament injuries have benefited significantly from stem cell therapy. By regenerating cartilage and promoting tissue repair, it provides a non-surgical alternative to joint replacement.

Neurological Disorders: Stem cell therapy is being explored for its potential to treat conditions like Parkinson’s disease, multiple sclerosis, and spinal cord injuries. Research has shown that stem cells can replace damaged neurons and support nerve regeneration.

Autoimmune Diseases: Chronic conditions like lupus, rheumatoid arthritis, and Crohn’s disease can be debilitating. Stem cell therapy offers hope by modulating the immune system and reducing harmful inflammation.

Cardiovascular Health: For patients with heart disease or damaged blood vessels, stem cell therapy helps repair cardiac tissue and improve heart function.

Skin and Hair Regeneration: Beyond internal applications, stem cell therapy is also used in cosmetic procedures to rejuvenate the skin, treat scars, and even promote hair growth.

Cancer Treatment: Stem cell transplants have been a cornerstone of treating certain cancers like leukemia and lymphoma. They help restore healthy blood cells after chemotherapy or radiation therapy.

The Global Expansion of Stem Cell Therapy

The demand for stem cell therapy has grown exponentially, prompting medical professionals and organizations to expand access to these innovative treatments. Clinics specializing in regenerative medicine are opening worldwide, offering cutting-edge therapies to patients in need.

For instance, one pioneering clinic founded in Toronto has taken its mission global, establishing partnerships in cities like Dubai, Los Cabos, and Tokyo. By forming strategic alliances, such organizations aim to make stem cell therapy accessible to a broader audience, transcending geographical and economic barriers.

Benefits of Stem Cell Therapy

Stem cell therapy is not just a medical treatment; it is a revolution in how we approach health and healing. The benefits of this therapy include:

Minimally Invasive Procedures: Unlike traditional surgeries, stem cell therapy often involves simple injections, reducing recovery time and risk.

Personalized Treatment: Since stem cells can be harvested from the patient’s body, the therapy is tailored to individual needs, ensuring optimal outcomes.

Reduced Reliance on Medication: By addressing the root cause of medical issues, stem cell therapy reduces the need for long-term medication and its associated side effects.

Improved Quality of Life: Patients often report significant improvements in mobility, pain reduction, and overall well-being.

Potential for Disease Prevention: Stem cell research holds promise for preventing degenerative diseases before they take hold, offering hope for healthier futures.

Challenges and Ethical Considerations

While stem cell therapy offers immense potential, it is not without challenges. Ethical concerns surrounding the use of embryonic stem cells have sparked debates, though many clinics now focus on adult stem cells and other ethically sourced materials. Additionally, regulatory frameworks vary across countries, impacting the availability and standardization of treatments.

Patients must also be cautious about clinics offering unproven therapies. It is crucial to seek treatment from reputable providers with a track record of success and adherence to ethical standards.

The Future of Regenerative Medicine

The field of regenerative medicine is evolving rapidly, with stem cell therapy at the forefront. Ongoing research continues to unlock new possibilities, from gene editing to advanced tissue engineering. These innovations are set to redefine how we treat chronic diseases, repair injuries, and enhance overall health.

In the coming years, we can expect further integration of technologies like artificial intelligence and precision medicine into stem cell therapy. These advancements will enable more accurate diagnoses, personalized treatment plans, and better patient outcomes.

Why Choose Stem Cell Therapy?

For individuals seeking alternatives to conventional treatments, stem cell therapy offers a beacon of hope. It represents a paradigm shift in healthcare, focusing on healing rather than merely managing symptoms. By harnessing the body’s natural regenerative abilities, stem cell therapy provides a sustainable path to recovery and improved quality of life.

A Canadian-based regenerative medicine company has been at the forefront of this movement, delivering innovative treatments to patients across the globe. With a mission to make cutting-edge healthcare accessible, the organization is setting new standards in patient care and medical excellence.

Taking the Next Step

If you are considering stem cell therapy, it is essential to consult with qualified medical professionals who can guide you through the process. Look for clinics with a proven track record, a team of skilled physicians, and a commitment to ethical practices. By choosing the right provider, you can embark on a transformative journey toward health and healing.

Stem cell therapy is more than a treatment; it is a testament to the power of innovation and the promise of a healthier future. As research progresses and access expands, regenerative medicine is poised to touch countless lives, offering hope where traditional treatments have fallen short.

[bestgoodbacklinks]

Revolutionary Advancements in Type 1 Diabetes Treatment in 2025

The medical landscape is witnessing unprecedented transformations, and type 1 diabetes treatments in 2025 are at the forefront of this evolution. As researchers break new ground, patients can now anticipate innovative therapies that promise to improve quality of life and disease management. Here, we explore the most significant advancements in T1D 2025 treatment, examining their potential to reshape care protocols globally.

Understanding Type 1 Diabetes and Its Challenges

Type 1 diabetes, an autoimmune condition, results in the body's inability to produce insulin. This leads to elevated blood glucose levels, requiring lifelong insulin administration. Despite the progress in care, traditional treatments often fall short of offering patients the freedom and control they need. Challenges like hypoglycemia, lifestyle constraints, and long-term complications underscore the importance of innovative solutions.

Breakthrough Therapies for Type 1 Diabetes in 2025

1. Advanced Artificial Pancreas Systems

Artificial pancreas technology has taken a quantum leap in 2025. These closed-loop systems integrate continuous glucose monitors (CGMs) with insulin pumps, using advanced algorithms to automatically regulate blood sugar levels. New devices, such as next-generation hybrid closed-loop systems, offer improved accuracy, adaptability, and connectivity with mobile apps, empowering patients like never before.

Improved Algorithms: Enhanced AI-based algorithms predict glucose trends more precisely, reducing instances of hyper- and hypoglycemia.

Compact Designs: Sleeker and more portable systems make daily use more convenient.

Cloud-Based Insights: Integration with cloud platforms allows healthcare providers to monitor patient data remotely and make timely interventions.

2. Beta Cell Replacement Therapies

Beta cell replacement has emerged as a game-changer in type 1 diabetes treatment. Researchers have made strides in stem cell-derived beta cell therapies, offering a potential cure by restoring the body's ability to produce insulin naturally.

Stem Cell Innovations: Advances in stem cell research enable the generation of functional beta cells that can be transplanted into patients.

Encapsulation Technology: New encapsulation techniques protect transplanted cells from immune system attacks without requiring lifelong immunosuppressive drugs.

Clinical Trials Success: Several ongoing clinical trials show promising results, with patients achieving insulin independence for extended periods.

3. Immune Modulation Therapies

Immune modulation is transforming the way we approach the root cause of type 1 diabetes. In 2025, therapies targeting the autoimmune response have demonstrated significant potential to delay or even prevent disease progression.

Monoclonal Antibodies: These therapies block immune pathways responsible for beta cell destruction, preserving residual insulin production.

T Regulatory Cells (Tregs): Research on Tregs focuses on restoring immune tolerance, reducing the attack on beta cells.

Early Intervention: Immune modulation is especially effective when administered during the early stages of disease onset, offering hope for at-risk individuals.

4. Smart Insulin Formulations

The development of smart insulin formulations has revolutionized insulin therapy. These insulins activate in response to rising blood glucose levels, eliminating the need for precise dosing.

Glucose-Sensitive Insulins: New formulations mimic natural insulin secretion, responding dynamically to glucose changes.

Extended Efficacy: Long-acting variants reduce the frequency of injections, enhancing patient compliance.

Fewer Side Effects: With more controlled delivery, risks such as hypoglycemia are significantly minimized.

5. Non-Invasive Glucose Monitoring

In 2025, non-invasive glucose monitoring devices have moved from experimental stages to practical, widely available tools. These devices provide painless glucose tracking, encouraging better adherence to monitoring routines.

Wearable Tech: Smartwatches and skin patches now double as glucose monitors, offering continuous insights without finger pricks.

Enhanced Accuracy: Innovations in optical and biosensor technology ensure reliable readings.

User-Friendly Interfaces: Intuitive apps and visualizations help patients make informed decisions about their diet and insulin dosing.

The Role of Digital Health in Diabetes Management

Digital health platforms are playing a pivotal role in reshaping type 1 diabetes care. By leveraging data analytics, telemedicine, and patient-centric tools, these platforms enhance both patient outcomes and healthcare delivery.

1. AI-Driven Insights

AI-powered tools analyze vast amounts of glucose data to provide personalized recommendations for patients and healthcare providers.

2. Virtual Clinics

Telemedicine has streamlined access to endocrinologists and diabetes specialists, reducing geographical barriers to care.

3. Educational Resources

Interactive platforms educate patients about disease management, empowering them to take proactive roles in their treatment plans.

Future Outlook: Towards a Cure for Type 1 Diabetes

The year 2025 represents a turning point in the fight against type 1 diabetes. While these innovations bring us closer to a cure, the journey is far from over. Collaborative efforts between researchers, pharmaceutical companies, and healthcare systems will be key to translating these breakthroughs into accessible solutions for all.

As we step into a new era of diabetes care, one thing is clear: hope is on the horizon for millions of individuals living with type 1 diabetes.

[postsforposting]

this is completely bullshit. you are really trying to say that the variety of breeds of cats and dogs somehow makes it easy to tell what their ideal body is supposed to be, but not humans, who do not have "breeds" or huge variations in their standard sizes like cats and dogs do, that it's somehow impossible to know it's unhealthy for a person to be 300lbs overweight? cmon, you're smarter than that. this is an emotional, defensive argument from a place of shame, not facts.

the reason that a pet's weight matters is because they do not get a choice, and in fact they cannot make choices, about their own health and lives. they cannot make an informed choice about whether they want to lose weight or not. they do not get to make that choice because it is fully known that even a small amount of extra weight is highly detrimental to the health, lifespan, and quality of life of the animal. it is abuse to subject an animal to being 100 lb when it should be 20. that is not even a question. it does not get a choice, just like it can't make a choice about eating toxic substances.

you, as a human? you can make that choice. you're lactose intolerant, but you wanna eat the ice cream anyway? your choice, buddy, because it's your body. the cat does not get to make that choice about eating a lily and snarfing a ball of yarn or a plastic bag. you want to refuse chemo or whatever medication because the side effects will destroy your quality of life? yep, sure can. you want to be 600 lbs when the ideal weight for the average human is less than 200? go for it, it's your choice if you want to die early and not be able to comfortably move around the world. you get to make the choice to damage your cardiovascular and musculoskeletal health, because you have the autonomy to do that, just as top sports athletes choose to cause incredible damage to themselves for money.

what you don't get to do is lie to other people that what you're doing is healthy and not damaging. you don't get to do it to your children for the same reason it's animal abuse to do it to your pets. it's nobody's business but your own if you are happy with being overweight and you choose not to undergo treatment for that for whatever reason, just as you can choose to refuse treatment for anything else.

but you don't get to spread misinformation and lies. that is no different than spreading snake oil cancer treatments and churches scamming people. you should not feel a need to lie to other people, or to yourself, about your own decisions in order to be happy with your life. you should not have to lie to yourself that you're healthy in order to feel content with your choices. you should not feel bad about the choices you're making if you're truly happy with them. do you actually not want to be obese, but it's too hard to do the work to change that? acknowledge that fact. you will be happier for it. it does not mean you hate yourself, any more than people who are chronically ill hate themselves by wishing for a cure. you have decided the treatment is worse than the condition, and that is true for a lot of things. that is why you get to have medical autonomy in the first place. it is nobody else's business what your health status is.

we do not collectively shame cancer patients for "being unhealthy" and failing to cure themselves. we do not shame HIV patients or people with autoimmune diseases for not choosing to destroy their immune systems and get stem cell/marrow transplants in order to cure themselves. telling people lies about facts of health indicates shame on the part of the liar, not self esteem and pride. cancer patients don't go round bleating about how it's perfectly fine to have malignant tumors and how it doesn't affect them at all and how they're just as happy and healthy as everyone else. you do not need to, and should not, assert that perfect health is required before society should grant you basic respect, autonomy, and love.

claiming you are healthy while overweight is not doing the body acceptance ideal any favors, it is actively undermining it by underlining how important it is that your body is indeed other people's business, that how you should be treated must be determined by how competent you are believed to be aka how healthy you are believed to be. people should not lose access to safety and autonomy and be abused because they are unhealthy. stop buying into the idea that lack of health means people deserve to be spit on or treated as inhuman and have their lives taken from them. it's not cute, it's not radical, it's not ~~pride, it's nothing more than that same story of throwing someone else to the wolves by trying to argue that those people actually are more deserving of cruelty than you are by the traditional rules. fuck the rules, the rules are what ruin people's lives. stop kowtowing to it.

again and tldr: animals don't have competency to make medical decisions for themselves. humans do. facts of health are known and objective. denying them makes you look stupid and weakens your claim to being competent, which is what you are actually arguing you possess that means the mob should go destroy someone else who isn't. don't make stupid, shitty arguments to score points with trads when you can make better ones that won't cost you or anyone else their humanity.

if ur confused about why animal people advocate for keeping your pets at a "healthy weight" but sometimes also in the same breath will advocate against human diet culture, its because we know what body condition a cat is supposed to be at optimally. but literally there is not one for humans as far as we can tell.

humans are a weird, opportunistic, hyper-adaptable and variable primate and we have evolved to have a LOT of variety in size, shape, metabolism, and weight retention. this has been essential to survival in hard times and easy times. you know the thing people talk about sometimes how about half the population are night people and about half are morning people so we'd be better able to watch at night as a group? yeah, weight variation is like that: there's a lot of latent variation in human populations because as a community we survive significantly better if some of us are fuckin ready to not die during the longass winter of death and some of us can eat their weight in fish and then run a mile immediately after. this is also why some people gain muscle crazy fast and some people don't: muscle requires a lot of energy, so some people are built to gain a lot during a plentiful season and be really efficient then and some people are built to use less energy over time and be more useful during a long hungry period. cats and almost all other vertebrates simply don't have this kind of complex community variation built in, and tend to be much more uniform in build and weight. humans tend to be really variable in body and brain, and that's one of the biggest factors that's made us so successful! there are just a LOT of ways to be a human being.

all of the "science" on "ideal human body condition" we have at the moment is almost entirely bullshit and was done by white supremacists for eugenics purposes. it's just not something we know, and right now there's significantly more evidence that there is no ideal body type for everyone to reach. recent research indicates that humans are healthiest at a variety of weights and builds, and dieting is almost universally bad for you. even if the culture hasn't caught up yet.

[byizii]

Human induced pluripotent stem cells hold promise for diabetes treatment

Diabetes is gradually becoming one of the biggest health challenges in modern times. Since 2017, the World Health Organization has classified diabetes along with cancer, respiratory and cardiovascular diseases find out more here as the top four non-communicable diseases to be addressed by global health authorities. A war against diabetes thus started.

Over the past decades, peptide-based diabetes mellitus treatment has led to a revolution in the treatment of diabetes due to their multi-functional properties. The most studied diabetes-related peptides include Amylins peptide, Chromogranin A, Exendins Fragments, Insulin C-Peptides, Insulin-Like Growth Factors (IGF) and more.

Stop the “sugar tide”

Despite manifesting as a simple disease, diabetes actually takes many forms. Type I diabetes occurs because the autoimmune response destroys beta cells - the insulin-producing cells in the pancreas. On the other hand, type 2 diabetes (T2D) occurs because cells no longer respond to insulin. Little known is monogenic diabetes, which is a rare form of diabetes caused by mutations in a single gene. However, over time, islet β-cell failure and β-cell death are a common feature of all types of diabetes.

Diabetic drugs can help patients control blood glucose levels for a long time, but they can't cure or improve the health of pancreatic beta cells. Obesity is the main cause of diabetes in the US, while pancreatic β-cell failure is the main cause of diabetes in Asia. Therefore, some research teams believe that stem cells could be used to fight diabetes. Unlike most cells in the body, stem cells have the ability to self-renew and can differentiate into a variety of cell types, including pancreatic beta cells. Therefore, stem cells may be used to replace dead pancreatic beta cells in patients with diabetes, thereby restoring insulin production and glucose regulation in these patients.

hiPSCs and diabetes

Stem cells can be obtained by first reprogramming blood cells and fibroblasts (a type of cell in the skin) of people with diabetes into human induced pluripotent stem cells (hiPSCs), and then, before these hiPSCs can be differentiated into pancreatic beta cells and transplanted back to the patient, gene editing is performed to correct diabetes-related mutations or gene mutations. This approach potentially allows for an almost unlimited supply of islet beta cells for cell replacement therapy. Since what was transplanted is the patient’s own cells, the possibility of transplant rejection is less likely to occur.

In addition to cell replacement therapy, hiPSCs can help elucidate the underlying molecular mechanisms of diabetes. For example, hiPSCs from patients diagnosed with MODY (maturity-onset diabetes of the young, a subtype of monogenic diabetes) is helpful in understanding how genetic networks control pancreatic and liver development. These two organs are essential for normal glucose metabolism.

In addition, by using hiPSCs as a platform for genetic screening, scientists may be able to better divide patients into different treatment groups. At the same time, it is possible to identify new drug targets based on such screening methods. This will make the ideal of precision medicine for diabetes closer to reality as a one-size-fits-all solution is not suitable for all patients, and should be prescribed based on the inherent genetic defects unique to each patient with diabetes.