#Reversible Inhibition

[dr-afsaeed]

TRPV1 inhibition sensitizes tumors to PD-1 blockade by reversing resistance to CTL-mediated killing

TRPV1 inhibition sensitizes tumors to PD-1 blockade by reversing resistance to CTL-mediated killing Summary TRPV1 inhibition can enhance the effectiveness of PD-1 blockade immunotherapy in treating tumors. Tumors can develop resistance to cytotoxic T lymphocyte (CTL)-mediated killing, a key mechanism of PD-1 blockade. Studies reveal that blocking TRPV1, a pain receptor, reverses this resistance,…

[wendelsae]

actually- is there any half-decent reverse image search anymore?

[lilianasgrimoire]

Herb Correspondences - S-Z

Sage - Used for self-purification and cleansing.  Helps grief and loss. Healing and protection also increase wisdom.   Element Air. 

Sandalwood - Burn during protection, healing, and exorcism spells.  Aids luck and success, meditation and divination. Raises a high spiritual vibration. Element Water. 

Skullcap - Aids in love, fidelity and peace.  Increases harmony. Element Water. 

Sea Salt - Use to cleanse crystals and tools.  For purification, grounding and protection.  Supports ritual work. Absorbs negativity and banishes evil.  Element Earth & Water.  

Sheep's Purse - Prosperity, protection and healing. Element Earth. 

Sheep Sorrel - Carry to protect against heart disease. Cleansing and increases luck.  Use in faery magic. Element Earth. 

St. John's Wort - Worn to prevent colds & fevers.  Induces prophetic and romantic dreams. Protects against hexes and black witchcraft.  Increases happiness. Use in Solar Magic. Element Fire. 

Star Anise - Consecration, purification, and happiness.  Use for curse breaking or increasing luck. Burn to increase psychic awareness.   Element Fire.  

Strawberry Leaf - Attracts success, good fortune, and favorable circumstances. Increases love and aids pregnancy. Element Water. 

Sunflower - Energy, protection, and power.  Aids wisdom and brings about wishes.  Use in fertility magic. Element Fire. 

Sweet Cicely - Use during rituals for the dead or dying.  It helps with divination and the contact of the spirit.  It is sacred to the Goddess’ of death. Element Earth. 

Sweetwood - See Cinnamon.   

Tansy - See Agrimony.  

Tarragon - Increases self-confidence.  Use in Dragon magic. Aids healing after abusive situations.   Element Fire. 

Tea Leaves - Use for courage or strength. In tea for increasing lust. Burn leaves to ensure future riches.  Element Air. 

Thistle - See Blessed Thistle.  

Thyme - Attracts loyalty, affection, and love. Increases good luck and psychic power.  Drink tea to aid sleep. Element Air.  

Valerian - Also called Graveyard dust. Aids sleep is calming and is a sedative.  Quietens emotions. Supports protection and love. Element Water. 

Vervain - Strengthen other herbs. Helps, peace, love and happiness.  Burn the leaves to attract wealth and keep your youth. Increases chastity also.  Element Water. 

Verbena - Psychic protection, peace and purification.  Healing and helps depression. Increases beauty and love.  Mind opening and clearing. Ideal use for exams. Element Earth.  

Violet - See Heart’s Ease.  

White Willow Bark - Use in lunar magic.  Reduces negativity and removes evil forces and hexes.  Used for healing spells. Element Water. 

Willow - Used for lunar magic, drawing or strengthening love, healing, and overcoming sadness.  Element Water. 

Witches Grass - Happiness, lust, love, and exorcism. Reverses hexes.  Element Earth.  

Wood Betony - Use for purification, protection, and the expulsion of evil spirits and nightmares.  Draws love in your direction. Element Fire. 

Woodruff - Victory, protection, and money.  Element Air. 

Wormwood - Used to remove anger, stop war, inhibit violent acts, and for protection. Use in clairvoyance, to summon spirits, or to enhance divinatory abilities. Element Earth. 

Yarrow - Healing, calming and increases love. Used in handfasting & weddings.  Increases psychic power and divination. Gives courage when needed. Element Air. 

[reasonsforhope]

"People living with diabetes might have a new hope. Scientists have tested a new drug therapy in diabetic mice, and found that it boosted insulin-producing cells by 700% over three months, effectively reversing their disease.

Beta cells in the pancreas have the important job of producing insulin in response to blood sugar levels, but a hallmark of diabetes is that these cells are either destroyed or can’t produce enough insulin. The most common treatment is regular injections of insulin to manage blood sugar levels.

But a recent avenue of research has involved restoring the function of these beta cells. In some cases that’s started with stem cells being coaxed into new beta cells, which are then transplanted into patients with diabetes. Researchers behind this kind of work have described it as a “functional diabetes cure.”

Now, scientists at Mount Sinai and City of Hope have demonstrated a new breakthrough. Previous studies have mostly involved growing new beta cells in a lab dish, then transplanting them into mice or a small device in humans. But this new study has been able to grow the insulin-producing cells right there in the body, in a matter of months.

The therapy involved a combination of two drugs: one is harmine, a natural molecule found in certain plants, which works to inhibit an enzyme called DYRK1A found in beta cells. The second is a GLP1 receptor agonist. The latter is a class of diabetes drug that includes Ozempic, which is gaining attention lately for its side effect of weight loss.

The researchers tested the therapy in mouse models of type 1 and 2 diabetes. First they implanted a small amount of human beta cells into the mice, then treated them with harmine and GLP1 receptor agonists. Sure enough, the beta cells increased in number by 700% within three months of the treatment. The signs of the disease quickly reversed, and stayed that way even a month after stopping the treatment.

“This is the first time scientists have developed a drug treatment that is proven to increase adult human beta cell numbers in vivo,” said Dr. Adolfo Garcia-Ocaña, corresponding author of the study. “This research brings hope for the use of future regenerative therapies to potentially treat the hundreds of millions of people with diabetes.”

The results are intriguing, but of course being an animal study means there’s still much more work to be done before it could find clinical use. So far, harmine alone has recently undergone a phase 1 clinical trial in humans to test its safety and tolerability, while other DYRK1A inhibitors are planned for trials in humans next year.

Perhaps most importantly, the team will soon experiment with combining beta-cell-regenerating drugs with others that modulate the immune system. Ideally this should help overcome a major hurdle: the immune system will continue attacking new beta cells as they’re produced.

The research was published in the journal Science Translational Medicine."

-via New Atlas, July 14, 2024

[witherby]

I totally had headcanon that mouse kinda has a reverse sleep schedule where they get more energy in the nighttime because of their powers and they’re more slumped and tired during the daytime (totally not projecting lol)

I think that might apply to Mouse if they lived anywhere that wasn't Gotham! The city is very dark and smoggy regardless of the time of day, so I think in Gotham they have a normal sleep schedule.

When they visit Conner in Metropolis or Smallville, however, they're practically dead on their feet midday.

"Hey, M?" Kon frowns, "You woke up three hours ago and you're...uh. You're dragging ass."

"Sunlight," you whine, slumped against him.

Conner is similarly affected in Gotham. Real sleepy in the city because the pollution is inhibiting his ability to absorb the ultraviolet rays.

[inamindfarfaraway]

Batman fun fact! Did you know that Scarecrow’s toxin doesn’t always cause fear? Sometimes it does the opposite! In Detective Comics #571, he wields a variant that completely inhibits the biochemical fear response, preventing people from feeling any concern for themselves or using basic common sense. He runs a racket administering it to star athletes, who take huge risks and get badly injured. Then they’re willing to cough up a lot for an antidote. Batman and Robin - here Jason Todd - catch on, but Bruce is dosed with the reverse fear toxin; since his intelligence is his greatest strength, being too overconfident and reckless to think twice about anything makes him his own worst enemy.

This premise was adapted in the Batman: The Animated Series episode “Never Fear”. There we see that with no fear of losing his moral integrity, Bruce becomes cold and merciless to criminals. Robin - here Tim Drake - has to catch somebody he leaves to fall off a building, tie him up to stop him endangering himself and others and give him the antidote to prevent him murdering Scarecrow.

But in the comic book, Jason is kidnapped by Scarecrow. He gets gassed and hallucinates Bruce dying and telling him that it’s his fault. He isn’t around to keep Bruce in check as he goes to rescue him through a series of death traps that he can’t resist cutting it as close as possible in. So how does Bruce not go off the deep end? How does he not lose sight of what’s important? Not lose himself?

Because even a drug designed to shut down stress at the most fundamental level can’t overpower his true worst fear. The Dark Knight might feel fearless…

but a parent never is.

[jollyhunter]

24 Kinky Days with Dean x reader - Day 5.

⚝‿︵‿୨♡ ⚝ ♡୧‿︵‿⚝

Pairing: Dean Winchester x fem!reader

Warnings: NSFW - MDNI! - includes explicit sexual content. It's a kinky writing challenge, so expect anything at this point, (nothing freaky, don't worry) but it's a surprise calendar so I won't spoil it! (Also, English is not my native language) Contains brief reference to Dec.1 (Sunshine)

Advent calendar includes: headcanons, snippets, one shots, imagines, blurbs etc.

Words: 1,330

⚝‿︵‿୨♡ ⚝ ♡୧‿︵‿⚝

A/N: Here I was, thinking I was real creative with this kinky UNO version - then my hubby told me "Ya know this game exists, right?" And of course it does. It's called "Dirty UNO" in case any of you is interested 🤭 On another sidenote, I changed the design for the kinky advent calendar posts! I was missing my Dean moods ayyy

⚝‿︵‿୨♡ ⚝ ♡୧‿︵‿⚝

5th Dec. - Dirty UNO

Dean grins cockily and laughs, “Are you ready to lose, baby?” He playfully wiggles the cards in his hands and winks at you.

You roll your eyes in mock-annoyance and let out a chuckle, “You wish honey, you wish.”

“I’ll make sure to not go to easy on you.” He grins and places down a Draw 2 card. “You owe me two shots and a kiss, gorgeous.”

You keep a straight face as you reach for the shot glass and hold it out for him to fill it up, “Gimme,” you nod at the bottle while you hold your 2 cards close to you.

Dean chuckles “As you wish,” and fills it up to the brim, you chug the whiskey down and he fills it once more, his green eyes gleaming in the dimmed light of the main room as he watches you down the second glass. “I guess I’ll take my other prize now,” he grins as he leans forward for a kiss, quickly capturing your lips in a passionate kiss and taking in the taste of alcohol on your lips.

You briefly swipe your tongue over the bottom of your lip before you draw two cards and add them to your deck, your expression turning mischievous. “My turn, sucker,” You cackle as you smack a Skip card onto his.

“Damnit,” he swears, but there’s no real bite to it - he wouldn’t admit it, but you knew he was gonna enjoy his punishment as much as you do. He quickly chugs down two shots before he stands up from his chair and walks around the table where he kneels down next to you, his hands slowly moving up your legs, “You’re gonna pay for that Skippi,“ he says playfully as he pushes you back onto the chair and spreads your legs.

You have to bite back a moan, determined to not lose this early. Your hands quickly go to unbutton your jeans and he hooks his fingers over the rim to pull them all the way down to your ankles along with your panties. The shots slowly make you lose your inhibitions and you tease him with a sultry smile, “Dig in.” He doesn’t have to be told twice and next thing you know he’s eating you out like a desperate man, his hands grabbing your thighs to keep them spread, his only goal to get some form of noise out of you. You bite your lips and throw back your head, fighting the urge to moan out loud when he’s suddenly sucking at your clit and you finally snap, that guttural moan slipping past your teeth. “There we go,” he hums in a satisfied tone as he pulls away from you, licking his lips, “I knew I would get you to make noises sooner or later,” he looks up at you with that cocky smirk of his before he pushes off the ground and returns to slump down on his seat across from you. “That was unfair,” you breath out shakily, your legs still trembling slightly.

Dean smiles smugly as he watches you try to compose yourself and place down a red 6. “You’re not getting out of this that easily, sunshine.” He grins and looks at his remaining 3 cards, “I believe it’s my turn again.” With a nonchalant flick of his wrist, he tosses a red Reverse card onto yours. He starts to unbuckle his belt while his eyes never leave yours and he has the audacity to wink at you with a tilt of his chin towards his crotch.

“Seriously now?” You scoff but cannot help the smile that tugs at the corner of your lips. You place your cards onto the table, face down, and with quick steps walk around the table, your eyes drifting down to his boner.

“Come on, sweetheart, on your knees.” He grins up at you and pats his thighs, fully aware of how cocky he is at the moment - and you know damn well he’s enjoying every second of it. This was payback, right? You kneel down next to his chair and your hand quickly snakes past his boxers rim to free his fully erected cock. With your free hand you fish out your phone and set the timer on one minute. “If you’re being a good boy for me, I might even make you cum in those 60 seconds.” You tease in a mock-sultry tone before you wrap your fingers around him and start to slide them up and down in a torturous slow pace. Every now and then you squeeze your hand to draw some sweet whimpers from him. His hands grip the edge of the chair and his hips involuntarily buck up towards you while his head drops back against the seat with a low groan. “Damn, baby…” he mumbles as he bites his lips and you start to increase the pace. You’re using just the right amount of friction, determined to make him come undone in the last 20 seconds with your fingers already glistening with his pre-cum. His eyes squeeze closed as he groans again, knowing he’s not going to last much longer and just when the alarm rings, his hips buck up one more time before he cums in the tight grip of your hand. “Fuck,” he pants out as the words leave his mouth, “That was… Damn…” You smile victoriously while you wipe your hand clean. “Told ya.”

After he had regained his composure and you sat back down to pick up your cards, you look up to eye the remaining two cards in his hand. “Your turn, honey.” You challenge him, trying to hide your fear of losing.

Dean notices how your eyes keep darting to his two remaining cards and he doesn’t miss the chance to grin at you smugly, ”Yeah, ‘m not gonna lie, I don’t have much left here.” He wiggles the two cards between his fingers, his emerald eyes glinting. “Looks like one of us will be naked soon. UNO.” he says while he places down a Draw 2 card. He fills the shot glass and shoves it across the table with a sly smirk, “Go on, down the hatch.”

“Damnit,” you curse silently, your head already a bit hazy of the past couple of shots. “Another two, huh,” you mumble as you down the first shot, letting him refill it before you force down the next one, the whiskey burning your throat as you empty the shot glass. “Alrighty, c’mere-“ you mutter, your voice already taking on a bit of a slur as the alcohol kicks in. You lean over the table and place a swift, sloppy kiss on his lips before you sit back down, adding the additional two cards to your hand. Your eyes narrow, scanning the numbers, until you have to realize that you have no way of stopping him. And honestly, you were kinda relieved about it. Dean is a sore loser and you don’t plan to deal with a grumpy Dean for the rest of the day – plus, it was kinda cute to see his victorious beaming smile. Feigning annoyance, you finally lay down a simple number card and watch his reaction.

Dean grins like a child as he watches you place down your card, realizing he’s got you now. “Looks like you’re in a bit of a spot now,” he teases as he stands up from his chair and walks around the table to stand behind your chair. He leans down to your ear and whispers with his voice a bit deeper than before, “I hope you’re in the mood for another loss, sunshine.” And without further warning he drops his last card onto the stack. His lips curl into a victorious smile as he slides the card with the game rules across the table and his finger taps the last line; Loser takes 2 shots, get naked and make their partner cum. “...Looks like it’s time to strip.”

⚝‿︵‿୨♡ ⚝ ♡୧‿︵‿⚝

Masterlist of opened windows:

1st Dec. - Sunshine 2nd Dec. - Spell Book 3rd Dec. - Lights Out 4th Dec. - Tickle 5th Dec. - Dirty UNO 6th Dec. - (TBA) 7th Dec. - Candlelight 8th Dec. - Hex Play 9th Dec. - Whip Stroke

…(check Masterlist for more!)

⚝‿︵‿୨♡ ⚝ ♡୧‿︵‿⚝

Tags:

@gardenofeden07 @deansjacket @literallylexa @lmpala1967

[thaltro]

Will your nightwatch au have any reimagining of how determination works, especially when it’s mixed with positivity, negativity, or void? Does it invert negativity/positivity by creating hope in despair and discontentment in happiness? Is it a force that resists the will of the creators/narrative (pro free will) or enforces it (anti free will)? If determination is amplified by the presence of negativity in order to ensure survival, can a determined character with negativity-based powers (not to assume what other ship kids may appear in the au or anything) with enough negativity going through their system doom spiral until the determination is tearing them apart at the seams?

(I have uh, been thinking about the logistics of this since mid 2018 don’t mind me)

Yes kinda - I’ll explain rn I medicalize a lot of concepts. I’ll also explain it inside the comic but here’s some minor stuff:

The main medical condition I focus on is “corruption”

In nightwatch, monsters bodies are incredibly vulnerable to foreign code. The most common example of this is getting sick, a monster absorbs a small viral bit of code, their body is overwhelmed and get symptoms of sickness, and eventually their body deals with the minor illness and everything is fine. But sometimes code changes can be too potent for a monster, creating chronic and sometimes terminal syndromes. This is what is called corruption.

Here are the three known corruptions (they are umbrella diagnoses)

Substance corruption:

substance corruption is the most common, (think nightmare and geno)

A potent substance that shouldn’t be within a monster gets in a monster and overwhelms their code permanently. This is a big category holding many different syndromes but the one thing in common is their physical form literally breaking down.

Some examples could be monsters having human soul substance injected into them, wether it be kindness or determination their bodies will be corroded slowly from the overwhelming code substance. Nightmare eating the apples count too, it’s code being too potent and quickly destroying his entire body.

This can be slowed down with treatment, reversion therapy is one but substance blockers are an alternative.

Void corruption:

Void corruption is rare, (think error, blue error, or fatal error)

When a entity is exposed to the Voids for too long, they may go through a slow process of void corruption. starting with sickness, then symptoms of confusion and amnesia, and lastly physical changes. The most identifiable trait is their final physical appearance, changes in color, additional limbs, open code numbers on anatomy, and glitching.

Their code gets randomized, new traits are gained and old traits are lost. Chronic pain, paranoia, hallucinations, delusional obsessions, and emotional instability are all caused by the distortion of their mind (and isolation of the void)

Treatment is difficult as a majority of patients show hostility to medical intervention. However reversion therapy is theorized to be affective for treating the patients.

Passive corruption:

Passive corruption is less common then substance but more common then void (think cross and killer)

When a conscious entity purposely changes another’s code. The victim goes through periods where they loose autonomy to the entity’s influence. The symptoms vary because it’s up to the foreign entity’s desire but it’s possible to see a change in voice, physical appearance, mental stability, and magical capabilities within the victim. The most well known example in the fandom is overwriting someone, but killer being controlled and reworked by the player is also passive corruption.

Reversion therapy and substance blockers work affectively as treatment.

Additional notes:

A monster can inhibit more then one category. For example, killer while gaining the substance of determination through passive corruption, would technically have both substance corruption and passive corruption.

This is a huge concept in nightwatch. There’s many additional elements like the specific affects of human soul substance, but i fear that would be too much of a rant from me.

Human traits are a medical thing in nightwatch, monsters cannot naturally have human substance, but can gain it through corruption. It’s not a trait of personality or belief or emotion.

It would be difficult to quantify and explain how human traits connect with feelings even within humans themselves, all systems I’ve seen do that don’t really make sense to me (cough glitchtale) so I made it a medical thingy. I’m not too sure if this is the answer you wanted but I tried.

[ivysangel]

Okay but a threesome with Dick and Jason. what would that be like? Are they competing to see who makes you come harder? Does each try to out do the other because he’s secretly jealous? Are they gonna Eiffel Tower? Is one really sweet while the other is being aggressive and rough? I need opinions.

-🧸

honey i am so so so so so sorry. this has been sitting in my drafts for so long and i hope you're still around to see it! i already wrote a lil smth smth about this a while ago here but allow me to elaborate.

i think the dynamic can get pretty crazy because dick can get wayyy nasty; not to say jason doesn't either, but i don't think jason would get crazy nasty in front of dick. dick's there to overstimulate you, tease you, play around with you, and bring you to the edge and back and then over, and jason's there to comfort you through it. i think they both could be "he talks you through it," guys, but in this specific scenario, i think it would be jason who sweet talks you, whispers in your ear, tells you you're doing so good for them, and quiets you down when you get too loud. i don't really know how to explain it, but he'd be the comforting presence out of the two of them, not even taking a submissive role or anything, just not as actively winding you up as much as dick.

dick, a menace as always, treats it like a game. how many times can he make you cum before you're begging for a break, and how many different ways can he make it happen. i think he'd be like that on a normal day, too, but i feel like it's very amplified in this situation because however this threesome happens, it's a very tense and intimate affair, out of character for both of them and, therefore everything about it is just different (?) i can't even think of a good way to explain it other than the next morning you're all kinda like woah. lost all inhibition the night before and don't really know how to go back to the way things were. he's quick to get nasty; he's the one eating you out while jason is kissing your neck and lightly grazing your skin, touching and squeezing, etc. the combination of both of them is really just insane, and both of their actions, in tandem, are what makes it so much more intense.

i do think they could be eiffel tower guys, but idk, i think (and walk with me here)…double penetration might be the way they go. like, you can't say, "dick grayson is an ass man," without admitting that he'd probably be into anal, so boom. and if your pussy is open, then yeah, ofc jasons taking it; it just makes sense TO ME. it's definitely a lot and not for the faint of heart, and you have to hold onto one (or both) of them while you get used to the sensation and while they find a nice rhythm, so it feels good for all three of you. during this part, the talking might die down just because you're all so in the moment; it's definitely out of character for dick because he's a D1 yapper, but it's cool cuz he was dirty talking so much during the foreplay, like lifting his head from between your legs just to look you in the eye and say something nasty.

i'm also ngl i could see the roles reversed where jason is eating you out or fingering you, and dick is the one whispering crazy shit in your ear. i could see it working both ways, but the first more so.

when i tell you this would be probably the best orgasm you've ever had, i mean that. there's just so much that went into it that there's really no way you aren't gasping for air and clutching your chest when it's over. damn near passing out, and they gotta shake you a little to make sure you're still kicking. and it's not even really over because if you show any semblance of energy after, they might try to go another round i fear.

[apas-95]

Nazi antisemitism was not based on “economic needs of German capital under the burden of postwar reconstruction”. The price of operating extermination camps and sending out death squads far exceeded confiscation of Jewish wealth. It was based on sincerely belief in Jewish racial inferiority and that Jews, communists, & social democrats had sabotaged the German war effort in WWI.

The direct primitive accumulation of appropriated wealth was not the only economic benefit of the German program of depopulation, this is fairly basic — was the colonisation of the Americas principally carried out for the purpose of seizing indigenous belongings? Were the massacres carried out in the European colonies, such as the Bengali famine, done for the seizure of the wealth of individuals? The very plain fact is that the depopulation of Germany proper and its newly-seized territories in the east was carried out as part of a plan of economic reconstruction explicitly based on European settler-colonial projects, wherein the destruction of fixed capital and the establishment of small-producer wehrbaueren was intended to both reverse and inhibit the tendency of the rate of profit to fall under capitalism.

The further notion that Weimar Germany's opposition to communists was out of revanchism and not an actual threat to the ruling classes and their state is genuinely hilarious, and goes directly against both what was explicitly stated at the time and also basic facts.

Your position here is basic idealism - if you're interested in being correct, I'd suggest looking into Dialectical and Historical Materialism, and On Practice, etc.

[khimkhim]

Getting Doughy

I’ve gained weight before but this time felt different. It felt absolute this time. The familiar feelings, small irritations, signs of a gluttonous lifestyle turned physical — all returned the way they’ve done it a dozen times in the past. My shirts began to tighten, strangling my biceps, chest, and collar. The hem of my shirts began to inch upwards, once reaching down to my zipper now barely resting at the top of my pants as my gut slowly pushes the fabric outward. My watches and rings begin to feel uncomfortable and I frequently wake up with my arms asleep, deprived of blood flow due to the fat swelling across my body cutting off circulation as I toss-and-turn in bed — likely because I stuffed an entire container of cookies before going to sleep. I catch myself snoring so loud that I wake myself up. And of course, it’s impossible to ignore my reflection, my growing reflection. My face widening and thickening. My jaw dissappearing, taught muscles softening into firm pillows of flesh.

The biggest change is my pants. I notice I have to move my belt loop two… three… notches further than a mere two months ago. My pants are tighter than ever, especially around my quads, buttocks, and groin areas. Weight gain hits my thighs and ass first, HARD, which means my pants are always the first to sacrifice themselves in the eternal war against obesity.

Getting ready to go to a formal event today, I try on my loosest pair of pants and struggle to put them on, the strained fabric of my trousers wrap around my thickening thighs like thin spring roll paper around a slab of pork belly. As I look in the mirror, my jeans halfway up my thighs, I notice my gut and the deep crease beneath it. My chest is puffy as well; the mass I’ve accumulated around my chest could legitimately fill a 38C cup size. These were fat tits. Jesus, I’m getting FAT.

As I shimmied my thickened thighs into the pant legs, I drop my phone on the ground and realize I’ve already bent over in these jeans 3 times too many and they likely won’t survive another excursion to the stretch zone, no matter how slow I squat. Alas, I slowly bend down toward my phone, my jeans instantly tightening and groaning around my thighs and ass. I roll forward on my toes, carefully rocking towards my phone when — *RIPPP*

I exhale and laugh, falling onto my succulent cheeks, feeling the cold hardwood floors against my bare skin. I place my hand around my backside and feel not one but TWO holes ripped on both sides of my jeans. I sighed, took them, admired the damage my incredibly plump ass did, and threw them away. I look in the mirror and realize how… thick… I’ve become. This isn’t the usual soft, pudgy, easily-reversible weight I’m witnessing on my body. This weight is a substantial, firm fatness that’s filled and molded every part of my body. Every muscle is padded with a thick layer of lard, forcing my body to adopt a new posture, altering the way I stand, walk, breathe. My stance is now wider to adapt to my bulky legs, my thick buttocks arch outwards just above my heavy thighs and thick calves. My gut is enormous now. I had never reached a point where I couldn’t suck in or adapt my posture to hide my flabby stomach. Now it jutted outwards, sagging only slightly, rounded above my groin almost 6 inches. The memory of musculature could still be seen beneath my stomach, legs, arms, and chest — but they looked pumped full of lard; once firm, hard muscles now bulged in all directions, inflating with a diligence only thousands of grams of sugar a week could sustain.

It would only be a matter of time before I started to break out in stretch marks. Maybe I was crazy, but I could feel them surfacing already. I scratched an itch on my gut and felt like I was scoring the top of sourdough before it’s placed in the oven to expand. I daydreamed of those beautiful lines on fresh baguettes; rising dough with small scores atop them to allow them to grow and spread without inhibition. “I can smell the fresh bread now…” I said to myself as I wistfully scratched my wobbly, doughy gut.

“Instead of going to this uptight, suffocating gala — I think I’ll make sourdough today.” I smiled to myself as I jiggled to the kitchen in only a small apron and nothing else.

[bambisnc]

             [ UNTITLED, track #6. ] ♡

. . to figure why this plays out again and again

### . STARRING ⌢ n.kz ⋆ angst + 0.6k // uneditted + mentions of a bf + friend!zuha is possessive asf ˖ ✧

🗨️ .. ⌞ XOXO ⌝ 1/5 btw + [m.list]

honestly, to nakamura kazuha, it’s him who’s always been the problem. 

your boyfriend.

who just so happens to be the current reason behind you showing up outside her place, hair sticking to the sides of your flushed face, eyes swollen and eyeliner smudged. 

looking like the prettiest mess she’s ever seen.

but this is nothing new. really, it’s almost a routine at this point; she never even asks questions. years of being your best friend have taught her otherwise. 

kazuha leads you straight to her bathroom, warm water readied with a fragrant bath bomb she knows you find comforting. a pair of her own, slightly oversized clothes wait for you inside too. and she doesn’t even have to check to know that her freezer is stocked with your favorite ice cream.

...

as she waits for you, she can’t help but let her thoughts wander. 

obviously, this isn’t one of those reverse isekai mangas you’re always ranting to her about. she knows that.

(kazuha doesn’t think she even wants that, to be fair. for some stranger to inhibit your body and try to woo her. anyone with your physical appearance could possibly make her defenses weaken, she’d mused another random evening.

but she wouldn’t fall for them. she’d be too busy being yours to ever even think about falling for anyone new, of course.)

... but this is real life. 

and in real life, it’s not as simple. 

as if it could ever be.

she hates it. hates the oh so obvious heart eyes you give to your newest fling, hates the way you devote yourself completely to them. it makes her physically grimace the way you excitedly spend your time making them cute little gifts, getting all prettied up for a random loser who she knows could never treat you as good as she could.

none of them ever really last, though. she makes sure of that.

you're hers, after all. plus the type of guys you seem to have a penchant for all seem to have one thing in common - fragile egos. you're so obviously out of their league that one single, casual mention of you being a tad bit more interested in some other guy and they go running.

worse come to worst, she'd just approach you with a worried tone and hesitant gestures and tell you how your boyfriend was acting .. really weird towards her. and you, the innocent soul that you are, fall hook line and sinker for her words every single time. a little white lie never hurt anyone, though, yeah?

...

her thoughts are interrupted when you walk to where she'd been sitting and sit right next to her. naturally, your darling friend waits no time in wrapping you up in her embrace, shushing when you start to feebly mumble out some words of gratitude.

kazuha hates to see you like this, she wants nothing more than to be able to whisk you far away from the cause behind this. she would do anything for you, get you your own personal fairytale if you just so much as said the word.

but you fixedly remain ever so oblivious to her feelings.

so she’ll do what is asked of her. she'll play the role of the supportive friend for as long as you need. she’ll be there to comfort you; press you closer into her, completely uncaring of the way your rapidly falling tears drench her shoulder. 

she knows she's perfect for you, she just needs to stick it out long enough for you to see it too.

𐙚 . regulars : none yet! ⋆

  [@bambisnc] 2k24

[sanarsi]

hello, my dearest Nari 🧡

with this ask I challenge you to write a ficlet (or anything bigger if you want) inspired by this screenshot:

may the writing muses be with you,

kissing you on your forehead (if you allow it not then just waving from the distance!)

ps almost sent you nudes

Father’s Love

Joel Miller x f!Reader

Summary: Life is a bitch that can surprise with reverse version of Joel’s nightmare. Warnings: angst, canon violence, child!reader Wordcount: 1,2k An: I wanted to write more so I don’t promise there won’t be a part 2. A wonderful plot twist was created in my head ugh. This is a part of this -> challenge by my lovely Aly (literally my muse) who almost!!! sent me dirty things.

Masterlist

Joel knew what he needed to survive.

As luck would have it, everything was within reach.

A working car, a gun and ammo, food supplies, and a few other things. The only thing standing in his way was a man, tall man and obviously well-trained, maybe a military? Joel had killed a lot of people and felt no inhibitions about doing it again, especially with such good loot waiting for him.

So he waited, hidden in the bushes, and silently just watched.

He wanted to wait until dark, maybe even until the man fell asleep, but the perfect opportunity presented itself earlier. The universe itself was giving him signs that he had to do it. And he had to do it now.

As quietly as he could, he reloaded his weapon, never taking his eyes off his enemy. The man sat with his back to him, completely unaware of anything, changing the bandage on his foot.

There was no better opportunity and Joel knew it. So he pulled the trigger.

The shot echoed through the forest and birds fled from nearby trees. He only watched as a limp body with a hole in its head fell to the ground. After that, there was dead silence.

He waited a moment, but definitely too short, before he decided to come out of hiding.

Maybe if he had stuck to his own principles back then he wouldn’t have done almost something he would regret for the rest of his life.

Hearing was faster than his sight at someone’s footsteps, he automatically aimed the gun in that direction. For a moment he didn’t know if he saw correctly when a child appeared in front of him. A little girl who was terrified and trembling with fear.

She looked exceptionally well-groomed. Unworn jeans, a sweatshirt and sneakers that looked almost new. No scars or dirt on her face. But it was her eyes that gave away the most — she didn’t see much evil. She looked as if Joel was the first person to make her realize that such a thing really existed.

Joel let out a slow breath and relaxed his muscles as he looked at her longer and longer. He lowered the gun a bit and with every passing second he saw her more closely, clearly. He felt a growing weight in his chest, as if the consequences of his actions were looking at him with those big tearful eyes. He didn’t want to think about what appeared in his head at the thought of the child but when her gaze fell on the body lying a few feet behind him, he knew that the weight of guilt was just starting to crush him. Slowly and painfully.

“Daddy?” Her soft, breaking voice pierced the heavy silence. He shivered at the sound, so reminiscent of the one that followed him in his nightmares. Tears welled up in his eyes and he didn’t fight them when they started to roll down his cheeks.

Karma caught up with him in the worst possible way.

For the first time in several long years, he felt like he had failed again. Like his nightmare had become reality again, but this time, he was the one who caused all the evil.

He knew that with another burden he could not continue to live. He could not allow his nightmare to gain the strength to crush him.

So he let his instincts take over again.

“Hi kiddo,” he said in a slightly hoarse voice and managed a gentle smile. The girl met his gaze again. Tears refused to escape her eyes. “What’s your name?”

Joel watched as she clenched her fists tighter around the sleeves of her sweatshirt and shook her head, clearly not wanting to answer his question.

“’s all right,” he tried to assure her. As proof of his words, he slowly crouched down and tossed the gun aside. “See? I won’t hurt you.” He spread his arms in a friendly gesture and, despite the tears glistening on his cheeks, tried to look friendly.

You had to trust him. He had no other choice now.

“You seem like a smart girl.” He smiled wider. He almost managed to ignore the pain in his heart. “I’m sure your dad taught ya a lot of things, right?”

She nodded uncertainly. He tried to stop himself from moving too aggressively, not wanting to scare her. But the urge to grab her in his arms now and apologize for what he had done was overwhelming, almost unbeatable.

“Your daddy tell you how to cope when he can’t do it for ya?”

She denied again, “No.” Her soft and uncertain voice almost broke him in half.

He could hardly believe that after everything he had experienced, he found himself again in the same and yet completely different position as so many years ago. But life was a bitch.

“Can I show ya?” he asked, wanting to give her a choice, an illusory possibility, but she was just a child. A child he had hurt just as someone had hurt him.

Her chin quivered as she nodded, “’kay.” She was on the verge of tears. Her small body was shaking, whether from the cold or the emotion he didn’t know, so he barely managed to restrain himself from pulling her into a tight embrace.

“I know you’re a tough girl,” he praised her with a wide smile he was holding with all his strength. “You’re smart and I’m sure you could handle any obstacle, right?”

She listened to him carefully. She was fully focused on him and that made things much easier. She had to see only him, she couldn't look at the dead body lying behind him.

She couldn't.

“Mhm,” she murmured softly, clenching her fists tighter.

“Attagirl.” He laughed through his tears and took a deep, calming breath. “Your daddy said if he couldn’t take care of you,” he began slowly, moving closer to her. She wasn’t afraid. She didn’t back down. “I have to do it for him.”

He stopped in front of her and watched her reaction. She seemed to process his words, as if she didn’t understand their meaning. Seeing her confusion, he slowly knelt down in front of her with a warm smile and watched the confusion in her eyes for a moment.

She was so small, so innocent and pure…

“So you are my daddy now?”

And he barely stopped himself from choking on his tears.

He sobbed, covering his mouth and nodded without thinking. He couldn’t hesitate. He couldn’t let you see his hesitation. So he was sure of his new role. He was sure that he had to become a father again.

And he became it the moment she pressed herself tightly against his chest, burying her face in his neck, and his arms closed her tightly.

He felt it. Again. The strength that came from holding a small being in his arms, someone who depended only on him. And this time, he knew he wouldn’t fail, can’t fail.

Tags: @syd-djarin @yorksgirl @puduvallee @luciaispunk @theoraekenslover @bbyanarchist

[anexperimentallife]

Look, it's easy to see when fascism is coming if you just keep your eyes open, and I've been warning about it in the US for literally decades now--well before even the first time the orange shitgibbon sat in that office.

The following is not the ONLY sign, of course, but one hard and fast rule is that ANY country that institutes VAT taxes (especially on necessities) while cutting taxes on the ultra wealthy and large corporations is teetering on the edge of fascism. It might be a delayed slide, with occasional temporary reversals, but fascism is the end result when the government begins showing favoritism towards the ultra-wealthy. As I said, there are other signs (like scapegoating immigrants and minorities), but tax policy is a guaranteed indicator.

VAT taxes inhibit economic movement and target the poor (it's not like every poor person can just stop buying things forever), while taxes on the ultra-wealthy stimulate the economy. How does anyone in their right mind think that taking trillions of dollars out of the economy and hoarding it is good for ANYBODY except the hoarders?

"This country has no capital gains tax!" That country is flirting with fascism, Margaret. Know why you have to pay property tax on your house while the muskrat doesn't have to pay taxes on his hundreds of billions in stocks (even though they can be used as loan collateral)? Because you're not part of a class that's rich enough to force the government to favor you, Henry--that is the only reason.

[kings-highway]

KuroDai with #31?

Oh god I absolutely love these two. I love them so much. 🤍 I really, really need to write more for them holy shit I love them. Anyway, enjoy~

Daichi does a weird thing when they’re walking together. Whenever Kuroo finds himself wandering along the outside edge of the sidewalk, Daichi with grab him by the waist and move him around in front, to walk on the inside. 

It is… borderline invasive. It is a physical grab, a forced move, it leaves no room for question. The first time he did it, Kuroo had been baffled by the touch in general. Daichi was a physically affectionate person, but there’s something about your close male friend grabbing your waist and holding you that just sort of… raised some questions. 

But then he’d let go, and go back to walking now with their positions reversed. 

Kuroo cannot figure it out. 

Maybe he wants to… I don’t know, hold hands, or walk more close? Why does he keep moving him. 

To test it, when they stop to do a bit of window shopping on the way to the bus station, he pulls away to walk on the outside edge again. They get about two and a half steps before Daichi makes a sort of huff of annoyance, noticing their flipped positions, and reaches to grab Kuroo again, forcibly moving him.

Daichi’s hand lingers for a back, and Kuroo figures maybe this is flirting…? Maybe he’s finding excuses to touch and be close. A sort of flutter of confusion in Kuroo’s chest spurred on by his teenage lack of inhibition prompts him to make a move, and he returns the gesture, by looping his arm around Daichi’s waist and holding him snuggly. Like putting your arm around someone at the movies. Casual. Normal. 

He feels Daichi’s steps falter, then return to normal, and when Daichi looks up at him, Kuroo plays it so cool and looks away. He feels like his hand might be an annoyance, clammy and nervous on Daichi’s side, but he’s lucky that Daichi’s bafflement over the new walking position stops him from immediately asking questions. 

And then, suddenly, Kuroo realizes that Daichi didn’t ask questions. 

He’s letting him walk this way. 

He looks back over to him, and finds Daichi walking with his head down, ears tinted red as he avoids looking at Kuroo. This, of course, prompts Kuroo to realize oh shit wait this worked and feel his own face flush red. 

Good job, Kuroo. You absolutely nailed the context of this situation. 

[whomst-the-hell]

ok but also one of the major reoccurring issues with rogue and gambit is that rogue cant touch him right like its arguably the main issue, which is why their relationship in gambit vol3 is one of my favourites bc that dynamic gets reversed and its so interesting

in gambit vol3 its revealed that years ago gambit got a lobotomy to significantly inhibit his powers, and the way thats revealed is the lobotomy is reversed and gambit starts getting all his powers back. because of these huge power ups gambit is able to create some kind of kinetic barrier over himself which allows rogue to touch him (this isnt the first time they kiss but to my knowledge its the first time they kiss without something shutting off rogues power) and they spend a few weeks together with this new normal. then its revealed that one of those huge powerups gambit un-lobotomised is the ability to charge organic matter, an ability he cant really control which leads to these panels:

gambit vol3 #16

which is so so interesting to me like. i dont remember if this is explicitly stated but i would guess ‘i could accidentally explode anyone i touch’ was probably pretty high up on the list of reasons gambit got the lobotomy in the first place yk and i feel like that adds so much to his reaction to ‘i am a danger to everyone im physically close to’ because thats something he also had to deal with and actually couldnt deal with to the point of going to dr sinister for help (and even when he gets his powers back as an adult he removes them again less than 10 issues later) idk i think it gives him more respect and understanding for rogue i really enjoy it 10/10