#Rare genetic disorders in babies

[healthlifeai]

Rare Pediatric Diseases for Children

Discover vital information on rare pediatric diseases affecting children. Empower families with knowledge and support for better health outcomes.

[thelovebudllc]

Woman with rare genetic disorder delivers healthy baby after complex pregnancy

When Jessica Johnson, 36, began to experience labored breathing and heart palpitations, she quickly made an appointment to see a cardiologist. A CT scan showed she had two aortic aneurysms that could potentially require surgery. As a child, Jessica was diagnosed with Marfan syndrome – a rare genetic disorder that affects the connective tissue in the body and can impact various systems, including…

[polaroidcats]

What is vaginal lycantrophy?

Written by P. Cat, Professor of Species Shenanigans, PhD in Ugly Crying Science, and PhD in Gynecological Cryptozoology

Special thanks to my esteemed colleague and collaborator tumblr user @lynxindisguise, PhD in Spooky Ooky Ghost Sex, PhD in Ugly Crying Science.

Overview

Vaginal lycantrophy, more commonly known as werewolf pussy is a rare genetic disorder that affects about 0,03% of Britain's population. Most people with vaginal lycantrophy will not show any symptoms for the first 10-15 years of their lives, and only those who start to menstruate will get a clear confirmation of their lycantrophic status. However, any non-menstruating person carrying the lycantrophaginal gene may pass it on to their children. This article aims to give an overview of the most common symptoms and treatment options for this condition.

How to tell if my child is affected?

A person born with vaginal lycantrophy may experience unusual discomfort in their genitals in the weeks or months leading up to their first menstruation. Common symptoms of pre-pubescent children or young adults with vaginal lycantrophy include: stomach cramps, vaginal discomfort, unusual discharge, random bloodlust, dizziness, nausea, growling or purring vulvas, tiredness, mild fever, unusually thick and fluffy pubic hair, clitoral baby teeth, headaches. If you or your child show any of these symptoms do not hesitate to contact a doctor or healer to get confirmation of your lycantrophic status. The doctor can find out the lycantrophic status via genetic testing or a quick vaginal examination during the days surrounding the full moon, when the moonstruation usually occurs.

What are the symptoms of vaginal lycantrophy?

Once a lycantrophic person has experienced their first moonstruation, the symptoms of vaginal lycantrophy may vary, depending on the moonstrual phases:

The moonstruation/Full Moon

This phase usually starts two days before the full moon and ends two days after the full moon, lasting five days on average. Symptoms include:

Sudden growth of teeth and/or fangs in the clitoral area

Growling or howling noises coming out of the vulva

Dizziness, shortness of breath

Nausea

Random bursts of bloodlust

Sensitivity to silver (in severe cases even leading to allergic shock reactions)

Snapping and biting movements by the genital teeth

Breast tenderness

Genital toothaches

Restlessness or intense sleepiness

Shedding of regular pubic hair

Sudden appearance of thick lycantrophic pubic fur

The furricular phase:

This phase starts three days after the full moon and lasts until the new moon/ovulation. Symptoms include:

Disappearance of genital teeth and all other moonstruation symptoms

Shedding of lycantrophic pubic fur, quick regrowth of regular pubic hair

Minimal vaginal discharge

Ovulation/New Moon:

Slick and slippery vaginal discharge / mucus

Abdominal pain

Breast tenderness

Strong vaginal yearning when confronted with a moonless sky

The lycantrophal phase:

This phase starts the day after the new moon and lasts until three days before the full moon.

Mild or severe lycantrophic fever

Furry discharge

Mood changes

Trouble sleeping

Random bursts of blood lust

Increased need for cuddling

Bloating

If you are a carrier of the lycantrophaginal gene but do not menstruate during the full moons you should contact a specialist to ensure no other conditions are affecting the natural moonstrual cycle.

Diagnosis and Tests

Vaginal lycantrophy is generally diagnosed during the menarche. If a person exhibits any of the above mentioned symptoms or there are any other medical concerns, do not hesitate to reach out to your GP to get a referral for genetic testing for the lycantrophaginal gene.

Management and Treatment

The severeness of the lycantrophic symptoms dictate what forms of treatment are recommended. If you are suffering from severe symptoms, you may ask your doctor or healer about the use of wolfsbane. In recent years, several case studies (L. Indisguise & P. Cat 2025; 2024; S. Black-Lupin 2023; 2021; 2008; 2005; S. Snape et al. 1993; L. Lupin 1976) on wolfsbane have shown that it has few to no side effects (the biggest one being increased sleepiness and drowsiness) and offers great relief to persons not wanting to deal with the blood lust and snapping teeth. Wolfsbane turns the lycantrophic vulva into a regular canine vulva while keeping the lycantrophic vagina and uterus intact, alleviating the most uncomfortable symptoms of the condition.

Outlook/Prognosis

While living with vaginal lycantrophy may require some accommodations during the moonstrual phases, there are no indications that people affected by it have a different life expectancy than people who are not carrying the lycantrophaginal gene.

[saanea]

Elsa and albinism

Summary:

My edit

Albinism

Testimonials

My theory

My edit

After seeing several edicts of the albino version of Elsa, I also wanted to do an edict of Elsa as a child, but it's not perfect. This person did it better than me.

Edits by diahanach ⤵

Albinism

Albinism is a rare, non-transmissible genetic disease that is inherited regardless of ethnicity. This rare genetic disorder affects pigmentation and is characterized by a deficit in melanin production. It can take several forms, depending on the genes responsible, with some forms affecting only the eyes and others affecting both eyes and skin. This genetic disease can result in a total absence of melanin pigment in the iris and integuments (epidermis, hair and body hair), despite the normal presence of pigment cells or melanocytes. Albinos are generally characterized by very light skin and hair.

However, albinism does not affect overall health, but they will need specific sun protection because their skin is sensitive to the sun and can develop skin cancer, and they also need eye care. There are several types of albinism, and the severity of the condition can vary according to the people affected. In terms of the color spectrum, they may have a full spectrum of colors, but on the other hand they may have certain visual peculiarities that affect their color perception and visual acuity.

In some countries, people with albinism suffer discrimination, poverty, stigmatization, violence and even death. In some countries, women who give birth to a child with albinism are repudiated by their husbands, and their children are abandoned or victims of infanticide.

Here are some links if you want to know more about albinism:

Testimonials

First testimonial: How Frozen's Elsa helped a little girl with albinism.

“Elsa from Frozen is recognisable the world over, but for one family she is more than just a Disney character. Canadian folklorist and journalist Emily Urquhart explains how the Queen of Arendelle became a positive role model for her daughter's albinism.”

“It is my daughter's first day at school and I nestle Sadie into line amongst her kindergarten classmates. Despite her many layers, strands of white hair poke out from beneath her hat and over the neck of her scarf. The little boy standing behind her leans in for a better look and shouts out "Hey, you have hair just like Elsa!"

For the uninitiated, Elsa, is the popular protagonist of the animated box office hit, Frozen. As a princess she is able to conjure up ice castles with her fingers and when her powers get out of control, locks herself away to protect her court. For my daughter, the comparison is positive.

Princess culture makes me cringe for all its misogynistic old-fashioned values, and yet, I'm alright with Elsa, who first appeared in 2013 when Sadie was three. Not because she's a strong female lead without a prince-driven narrative, but because she has white hair like my daughter.

The difference is, Elsa's hair is a manifestation of her icy prowess and Sadie has albinism - meaning she has little to no pigment in her hair, skin and eyes and wears glasses to correct what she can of her low vision.”

“The little boy who noticed my daughter's hair is just one of thousands of people who have remarked on her ivory locks. It began in the delivery room as half the hospital came to "see the white-haired baby" - only the janitor suggested she might have a genetic condition. On average we hear up to five comments a day - from "wow, her hair is really white" to "did you bleach her hair? or "are you Swedish?".

Now, I am so accustomed to hearing comments I barely register them, but then, as a new mother, those remarks emphasized my concerns for her future.

A few years later and strangers began likening Sadie to Elsa and it was as if this ubiquitous Disney character somehow normalised my daughter's difference.

For now, my daughter is a Frozen fan, so this works and gives people a positive hook to hang their comments on, although I do worry when Elsa is jettisoned in favour of other, new, characters.

Traditionally however, Hollywood has not been so kind. Characters who resembled people with albinism have been the villain, an evil other who is frightening and strange. Films like The Matrix Reloaded with Keanu Reeves and TV series Doctor Who have all used evil or strange "albino" tropes, but this is just one strand of mythology that surrounds this condition.

Sadie was born when I was studying for my PhD in folklore at Memorial University, Newfoundland and I found myself drifting away to research albinism and other cases of human differences in folklore.”

Source :

Second testimony: “I can't get her to be anything else”: Mother of a four-year-old girl with Albinism reveals how her daughter has found confidence again by dressing up as Elsa from Frozen.

● Hailey Brown was initially overwhelmed to discover her firstborn had Albinism

● She and daughter Arliyah were often approached by strangers touching her hair

● Things began to change when a child said the little girl looked like Princess Elsa

● Arliyah thinks she is Elsa and proudly shows her sister who also has Albinism

“A young girl with Albinism has found confidence in herself from an unexpected place - Disney's famous film, Frozen.

Four-year-old Arliyah Brown, from Queensland, had been the subject of stares and sometimes cruel questions before the film was released and another child pointed out she looked like Princess Elsa.

After watching the film, Arliyah now believes she is Elsa, and will take any opportunity to dress up as her possible.”

Source :

My theory

A few days ago I imagined and improvised a scenario based on these edicts, some theories about Elsa being albino and what I've learned about albinism. Without realizing it, I've sort of created my own theory about Elsa's albinism and I want to share it here.

Elsa hides her albinism as well as her powers all these years.

Ever since she was a child, Elsa has always known that she is albino, and the doctor and dermatologist regularly came to examine her to see if she had any other problems. In the 19th century, medicine wasn't as developed as it is today, so doctors did their best, but some patients were mistreated. The doctor who regularly came to examine Elsa gave little information to Agnarr and Iduna (the parents), and Elsa didn't know much about it either. One day, Agnarr and Iduna wanted to know more about albinism. The doctor didn't want to worry them, but they really wanted to know more for their eldest daughter. They were already aware that she could have skin and eyesight problems, Iduna often made her a cream that was both moisturizing and protective against the sun, and Elsa saw an ophthalmologist from time to time who recommended a pair of resting glasses with anti-reflective lenses just in case, but they knew nothing more.

I mentioned above, with the help of an article to which I've also provided a link, that albinos are discriminated against, abandoned by their parents and sometimes abducted from their families and killed. This is what the doctor explained to them in order to warn them and preserve the child. In those days people were quite religious, but some were quite superstitious and believed in prejudices, for example in some countries there were beliefs that people with albinism brought good luck, so sometimes they sold their hair or whatever, and in some countries albinism was considered to be something bad.

How did Elsa hide her albinism?

This idea didn't come from her (she was only about 8 years old) or her parents, it came from the doctor who recommended that they have the make-up artist from the castle come and put coloring henna on her eyelashes and eyebrows.

For those who don't know what henna is, here's a picture:

“Henna, known scientifically as Lawsonia inermis, is a flowering plant that has been used for centuries for its cosmetic, medicinal and cultural properties.”

Agnarr and Iduna had initially refused to color their eldest daughter's eyelashes and eyebrows, but the doctor insisted, so they desperately agreed. The henna can last 3 to 4 weeks before it fades and disappears. A few days later, I can imagine that the isolation had taken place and Anna didn't remember much except that she and Elsa were accomplices. Every 3 or 4 weeks for 13 years, the make-up artist applied henna to her eyes, and the ophthalmologist recommended that she wear colored contact lenses, which would turn her eyes an ordinary blue.

Have you noticed that Elsa often wears long sleeves?

After “Let it go”, although she now leaves her shoulders free, most of her outfits still have long sleeves, even in summer. The only time she wears a short-sleeved outfit is in Frozen fever for Anna's birthday. Anna also wears long-sleeved outfits most of the time, but less than Elsa, she has worn short sleeves at least 4 or 5 times, such as her children's pyjamas at the very beginning of Frozen 1 and 2, as well as the outfit where she sings “Do you want to build a snowman?” when she was still 5, her ball gown on Elsa's coronation day and her Birthday outfit in Frozen fever. It reminds me that Elsa has to keep her skin as safe as possible from the sun.

I'm going to leave it at that because I could go on with my theory that Elsa's real hair is curly and that she wears wigs that are 1 or 2 shades darker than her natural color, but I'd rather leave it at that for now because this article is already long and I'm too lazy to tackle the subject of wigs in this article. But I may do so in part 2, and I'll also talk about Anna and redhead genetics in another article.

❆

I really enjoyed writing this article and couldn't wait to share it here and I hope you've learned a few things too, I love tackling this kind of subject while staying in theme with the Frozen universe. ❄️

[creativity-deficient]

Random Tweek Tweak hcs bc im thinking bout him yet again :)))

-Has an undiagnosed anxiety disorder, made worse by the increased use of Methamphetamine over the years and mistaken for adhd (canon/implied canon), which I do like to think DOES have as well. He is also on the autism spectrum.

-Has mild Seborrheic dermatitis, a skin condition that causes red and flaky patches of skin and usually flares up due to stress. It starts mainly on his head/under his hair as a kid but worsens in his teens years. Also has dermatillomania (a skin picking disorder), as well. Both of these become a lot worse in his teen years, with the addition of meth induced skin sores and hormonal acne to boot, but do become a lot more manageable for him as an adult. Still however, he does have some faint scars from all the picking and scratching over the years.

-Small tubby lil guy :) (sorta?? implied canon??), below average in height and considerably pudgy compared to most of his peers (genetics/stress eating). Loses a lot of this weight in his teen years due to health issues, but does gain a lot of it back as an adult. Also has a pudgy baby face that he never quite grows out of, even as an adult.

-His eyes a blue hazel, a rare eye color

-Sometimes snaps and hums to calm himself down.

-Enjoys baking as a casual hobby, though he’s still an amateur and doesn’t know how to make much. (implied canon)

-Once joined every school club because he had an anxiety attack and couldn’t decide what to pick

-Habitual nail chewer, again something he usually does due to stress. Nails are very short and stubby because of this

-Bandages on his fingers due to burns, skin picking, and nail biting

-Chronic ice-chewer

-Never learns to tie his shoes. Kept tripping over his laces before finally taking them out. Untied laces to laceless shoes to crocs to socks with sandals to velcro shoes pipeline

-Also never learns to drive, too much stress. Forever in his passenger princess era ✨

-Lowkey a backseat driver, though not in a “know it all” type of way. He mostly just freaks out the entire time.

-Can not sleep in the car because he’s afraid the second he closes his eyes, they’ll crash.

-Doesn’t know much slang/internet lingo and has absolutely no idea what his peers are talking about half the time (pretends he does and usually just ends up looking stupid 😔)

-Has a fear of rubberhose cartoons, as well as those weird old stop motion Christmas movies (he just finds them unsettling)

-Told about the secret family recipe as a teenager by his father, and is reasonably freaked out about it. Is forced to keep his mouth shut about it and suffers through major withdrawals before his parents are eventually exposed and arrested for the distribution of meth/counts of child abuse. Spends most of his high school years in therapy and rehab, though it’s all made easier with Craig by his side

-He and Craig try breaking up their freshman year of high school, both of them feeling like they need to try new things for a bit. It lasts about a week before they get back together.

-TERRIFIED of scissors and refuses to let anyone come near him with them. Grows his hair out long as a teenager before finally caving in and shaving it off as a young adult. He now keeps it managed, but Craig is the only person he trusts to do so.

-Did once try to cut his own hair in middle school though, and he spent weeks looking like a train-wreck before finally letting his mom fix it.

-His relationship with his mom is considerably better than his relationship with his father, and though he never quite forgives her for what she’s done, the two of them are able to reach some sort of closure with each other in Tweek’s older age

[berrywinner]

HOLY SHIT!!!! OPENED REQUESTS FOR HOUSE MD!!!! may i request a platonic duckling!reader and house where reader turned out to be his bio child or something like that... tysm!!!!

I love you, kid

House has always treated you differently, neither of you ever understood why tho. Until one tuesday, everything comes out

You had always known working on Dr. House’s team wasn’t going to be easy. Chase, Cameron, and Foreman had warned you,well, Chase had warned you in that polite, sympathetic tone of his. Cameron had just given you a soft smile and a “good luck.” Foreman smirked. But you weren’t just the youngest on the team.

You were new, fresh out of your residency, and you’d somehow impressed House enough to land a spot on his diagnostic team. He hadn’t said why he chose you, he never did, but over the months, you realized you were different from the others. Not just in age. House treated everyone like an annoyance. He teased, taunted, and poked at their insecurities. With you… he still did that, sure. But there was something else. He watched out for you. He pulled you out of impossible situations. He rarely belittled you the way he did with the others.

And, more than once, when you stayed late and worked yourself to exhaustion, you’d wake up in his office, his old leather jacket draped over your shoulders.At first, you thought he saw you as some kind of little sister. But slowly, painfully slowly, it began to feel more paternal. He scolded you when you took risks. He grumbled at you to eat. He noticed when you skipped meals or stayed on your feet too long.You started calling him “House” like everyone else. But sometimes, in your head, he felt suspiciously close to Dad.

It happened on a Tuesday, like most strange things do. The patient was a sixteen-year-old boy with unexplained seizures, high fevers, and severe muscle weakness. Every test came back inconclusive.

“We’re missing something,” you murmured, staring at the whiteboard.

House twirled his marker between his fingers. “Very astute, Baby Intern.” He had started calling you that, half-mocking, half-affectionate. You sighed. “I mean something genetic. Something we’re not even looking for.”

House arched a brow. “You want to run a full genetic panel? Do you know how long that’ll take? We’ll be attending his funeral by then.”

“Not if we use rapid sequencing,” you said, surprising even yourself. “I’ve been working on a protocol with Dr. Jacobson in genetics.”

House stared at you for a long moment. “You’ve been busy.”

You shrugged, feeling small under his gaze.

“Fine,” he said. “Run it. But if it comes back as something boring, like a mitochondrial disorder, I’m revoking your marker privileges for a week.”

You smirked. “Deal.”

The next morning, you were halfway through the patient’s genetic results when something strange popped up. A secondary result.

It was an automatic database alert: a partial parental match.

You frowned, double-checking the patient ID. No error.

It was from a case House had run tests on three days ago.

You blinked. Checked again.

Parent-child match. 99.98%.

Between you… and House.

You sat frozen in the chair for what felt like hours.

Later that day, House called a team meeting. The patient had viral encephalitis. Treatable. Good news.

But your mind wasn’t on the patient. It was on the blood test results burning a hole in your pocket.

“Hey,” Chase nudged you as the meeting broke up. “You okay? You’re pale.”

“Yeah. Fine.” Your voice cracked.

You stayed behind.

House was scribbling something on the board. He didn’t turn when he spoke. “You look like you’ve seen a ghost.”

“House… can I talk to you?”

“Unless it’s about getting me a better brand of coffee, save it.”

“It’s important.”

He finally turned, studying your face with that unnerving, perceptive gaze. “Okay. Talk.”

You swallowed. “I ran a genetic panel on the patient. There was another process in progress, and I have seen the results .”

House��s face didn’t change. But his hand tightened slightly on the marker. “Mh...”

Silence.

He knew something.

You took a shaky breath. “House… it says you’re my father.”

He didn’t laugh. He didn’t make a joke. He sat down heavily in his chair and looked at you like he was seeing you for the first time.

“I thought it was only a presentiment..."he started.

Your voice trembled. “How did you think about even take a DNA test? My mom died when I was ten. I never knew my biological dad. She said it was… someone she didn’t want to talk about. That he wouldn’t have wanted me, did you know I existed?-”

House looked down at the floor. For the first time, you saw genuine fear in his eyes.

“I… I didn’t know” he whispered.

The silence stretched between you, heavy and suffocating.

House rubbed a hand over his face. “We can run another test.”

“I already did. Three times.”

He nodded slowly. “Okay.”

You could barely breathe.

“I didn’t know I swear” he said again.

“I believe you.”

And you did.

You sat across from him in his office, your breath uneven, his hands nervously tapping against his cane. Neither of you spoke for a long time.

“I should’ve guessed when you came her the first time” House muttered finally, breaking the silence. His voice was quieter than you’d ever heard it. “You’re annoyingly stubborn. You ask too many questions. And God forbid anyone tries to tell you what to do.”

You laughed, but it broke into something like a sob.

House winced. “Don’t… cry.”

“I’m not.” You wiped your face quickly. “Just… processing.”

“I need a drink,” House finally said, standing abruptly.

“Yeah. Me too.”

You ended up in a bar. And in the moment you chose your drink he spoke

“I can already see the genetics”

The silence settled again, but this time it felt warmer. Calmer. He finally sat down beside you and exhaled like he’d been holding his breath for years.

The days that followed were strange.

At first, nothing changed. There were still cases, still rounds, still differential meetings with Chase, Cameron, and Foreman. House still teased everyone mercilessly.

But something had shifted between you.

He checked in on you more often. Brought you coffee without a sarcastic comment. Left Post-it notes on your desk that read things like, Eat something.

He tried not to hover, but he wasn’t very good at it. Him looking after you wasn’t something new, but now he had started to be obvious about it.

You had never said the word "dad". But it hung in the air between you like a whisper. You hadn’t dared to call him dad and he hadn’t dared to call himself your dad.

But actions spoke louder.

He started driving you home when you stayed late. Sometimes, he’d leave your favorite snacks in the diagnostics lounge with no explanation.

One day, you caught a cold, and he practically barricaded you in his office with a blanket, soup, and orders not to move.

Chase and Cameron noticed.

“House is… weirdly protective of you lately,” Chase said one afternoon.

You smiled. “Yeah.”

“Like, really protective,” Cameron added, eyes narrowing. “Should we be worried?”

“No,” you said softly. “It’s… good.”

And it was.

The first time you called him Dad was an accident.

You were exhausted, half-asleep on the diagnostics lounge couch, and he was fussing about you skipping lunch again.

“Okay, Dad, I’ll eat,” you muttered without thinking.

The room went silent.

Your eyes flew open.

House froze, blinking at you in surprise.

You covered your mouth. “Oh my God, I didn’t–I mean, I–”

He exhaled a shaky breath.

“Say it again,” he whispered.

Your heart twisted.

“Dad,” you said softly, deliberately this time.

His face crumpled for half a second before he composed himself, but not before you saw it, the crack in his armor.

He sat beside you, tugged you gently against his side, and for the first time in your life, you felt safe.

It became easier after that.

He’d leave you notes signed “-Dad” just to make you smile.

You started bringing him coffee in the mornings and teasing, “Drink up, old man.”

Chase and Cameron finally cornered you.

“You and House…” Cameron began carefully.

“He’s my dad,” you blurted out.

They both stared.

Foreman nearly dropped his coffee.

House pretended to hate the attention, but you caught him smiling when he thought no one was looking.

Months passed. You spent holidays together. Watched old movies in his apartment. He taught you how to play piano, sort of. Mostly, he just teased you for being terrible.

But he beamed when you finally managed a simple melody.

You helped him with his leg on bad days.

You argued. You made up. You grew.

He became your father in every way that mattered.

One evening, you sat on his couch, curled up with a blanket, and he handed you a battered photo album.

“I thought you might want to see these,” he said softly.

Photos of him and your mother. College years. Smiles, laughter.

“She loved you, this is why he never talked about you” you whispered.

He swallowed hard. “I know. I just… didn’t believe I deserved it.”

“She thought you did.”

He looked at you then, eyes soft.

“And so do I.”

He looked at you, he didn’t think he'd ever want a child, he never believed in paternal instincts, until he started acting like a father before even knowing you were his kid.

And now, now he was a Dad...a real one. And he never felt so good.

A year later you stood in front of the diagnostics board, marker in hand, surrounded by Chase, Cameron, and Foreman. House sat behind his desk, pretending not to listen.

“Okay,” you said, taking charge. “Let’s run through symptoms we've missed something”

House smirked. “Bossing them around. Makes me proud.”

Chase rolled his eyes. “Definitely your child”

You grinned. “Damn right.”

House tapped his cane against the floor. “Wrap it up, Baby Intern.”

You turned, gave him a look.

“Sorry,” he corrected, eyes warm. “Baby genius.”

You beamed.

That night, you found yourself back on his couch, watching old movies, popcorn between you.

“I’m glad I found out,” he said softly.

You smiled. “Me too.”

He hesitated.

"What?" you said

“I love you, kid.”

You leaned your head on his shoulder.

“I love you too, Dad.”

And in that moment, for the first time, neither of you felt broken.

You felt whole.

[just-an-elf-with-the-socks]

In wake of my Modern AU Angbang, I thought I’d go ahead and share what my personal modern AU Mairon is like.

Is thirty-two but doesn’t look a day past twenty and he’s super proud of that

Was once an incredibly renowned jewelry designer in the high fashion industry until his eyesight began to deteriorate

Mairon is legally blind (this was me wanting to insert a tiny nod to the Eye)

Being legally blind isn’t the same as being blind; Mairon can still see, he just 20/200 vision, which means he can only see clearly about twenty feet in front of him

There wasn’t an any type of accident; Mairon has a rare genetic disorder called Retinitis Pigmentosa, causing severe vision loss beginning around age twenty-five

Mairon has a lot of internalized ableism but being with Melkor, who is also disabled, helps him come into his own about being comfortable with his disability

Mairon left home at a young age, determined to make himself known outside of a home where he had many siblings and was very much neglected due to being a “complicated” child

He has high taste and very often uses it to decorate his home or even make intricate sweaters for his dogs (knitting is a fun hobby for him)

Speaking of dogs, Mairon has three giant huskies. Their names are Draugluin, Thuri, and Minnie, who serves as his mobility aid

He really wants to be able to make jewelry professionally again, though he tries to hide it

Actually really good at playing the piano (this was how he met Melkor)

A great cook, loves to experiment, much to Melkor’s dismay (he’s just a baby that doesn’t want to try new things)

[mariacallous]

Last August, KJ Muldoon was born with a potentially fatal genetic disorder. Just six months later, he received a Crispr treatment designed just for him.

Muldoon has a rare disorder known as CPS1 deficiency, which causes a dangerous amount of ammonia to build up in the blood. About half of babies born with it will die early in life. Current treatment options—a highly restrictive diet and liver transplantation—aren’t ideal. But a team at the Children’s Hospital of Philadelphia and Penn Medicine was able to bypass the standard years-long drug development timeline and use Cripsr to create a personalized medicine for KJ in a matter of months.

“We had a patient who was facing a very, very devastating outcome,” says Kiran Musunuru, professor for translational research at the University of Pennsylvania and Children’s Hospital of Philadelphia, who was part of the team that made KJ’s treatment.

When KJ was born, his muscles were rigid, he was lethargic, and he wouldn’t eat. After three doses of his custom treatment, KJ is starting to hit developmental milestones his parents never thought they’d see him reach. He’s now able to eat certain foods and sit upright by himself. “He really has made tremendous strides,” his father Kyle Muldoon says.

The case is detailed today in a study published in The New England Journal of Medicine and was presented at the American Society of Gene & Cell Therapy annual meeting in New Orleans. It could provide a blueprint for making customized gene-editing treatments for other patients with rare diseases that have few or no medical treatments available.

When the body digests protein, ammonia is made in the process. An important enzyme called CPS1 helps clear this toxic byproduct, but people with CPS1 deficiency lack this enzyme. Too much ammonia in the system can lead to organ damage, and even brain damage and death.

Since KJ’s birth, he has been on special ammonia-reducing medicines and a low-protein diet. After receiving the bespoke Crispr drug, though, KJ was able to go on a lower dose of the medication and start eating more protein without any serious side effects. He’s still in the hospital, but his doctors hope to send him home in the next month or so.

Both KJ’s parents and his medical team stop short of calling the Crispr therapy a cure, but they say it’s promising to see his improvement. “It's still very early, so we will need to continue to watch KJ closely to fully understand the full effects of this therapy,” says Rebecca Ahrens-Nicklas, director of the Gene Therapy for Inherited Metabolic Disorders Frontier Program at Children’s Hospital of Philadelphia and an assistant professor of pediatrics at Penn Medicine, who led the effort with Musunuru. She says the Crispr treatment probably turned KJ’s severe deficiency into a milder form of the disease, but he may still need to be on medication in the future.

Ahrens-Nicklas and Musunuru teamed up in 2023 to explore the feasibility of creating customized gene-editing therapies for individual patients. They decided to focus on urea cycle disorders, a group of genetic metabolic conditions that affect the body’s ability to process ammonia that includes CPS1 deficiency. Often, patients require a liver transplant. While the procedure is possible in infants, it’s medically complex. Ahrens-Nicklas and Musunuru saw an opportunity to find another path.

When KJ was born, the researchers used genome sequencing to determine the specific genetic mutation driving his disease. It turns out KJ had actually inherited two different mutations in the CPS1 gene—one from each parent. The team decided to target the mutation that had been reported before in an unrelated patient known to have severe CPS1 deficiency; the other hadn’t been seen before.

KJ’s team turned to Crispr, the Nobel Prize-winning technology that can precisely edit DNA. So far, only one Crispr-based medicine is commercially available. Approved in late 2023, it treats sickle cell disease and beta thalassemia. Other Crispr-based therapies are in development for more common diseases that affect tens or hundreds of thousands of patients.

The allure of Crispr is its potential to directly address the underlying genetic cause of a disease rather than simply treat symptoms, as the vast majority of current medicine does. The approved Crispr therapy, Casgevy, is given as a one-time treatment. But the Philadelphia-led team specifically designed KJ’s therapy to be redosable out of safety concerns, starting with a low dose to ensure there were no adverse effects. Terry Horgan, a 27-year-old with Duchenne muscular dystrophy, passed away in 2022 shortly after receiving the first known custom Crispr treatment. His death was likely due to a reaction to the virus used to deliver the Crispr molecules.

For KJ’s treatment, researchers used a version of Crispr called base editing that can change one “letter” in a DNA sequence to another. They packaged the base-editing components in tiny bubbles called lipid nanoparticles, which were then delivered via an IV infusion.

Before it could be given to KJ though, it was tested for safety in mice and monkeys. Since the drug was unapproved, the team needed permission from the Food and Drug Administration to use the experimental treatment in an individual patient. The researchers applied to the FDA on February 14 and received approval on February 21. They gave KJ his first dose on February 25.

“The clinical responses described are impressive,” says Timothy Yu, a neurologist at Boston Children’s Hospital who wasn’t involved in making KJ’s treatment. He says the Philadelphia team’s approach was a “very thoughtful and comprehensive end-to-end process.”

Yu’s lab has been working on customized genetic medicines based on antisense oligonucleotides, or ASOs—short molecules that block the production of proteins. Yu developed a personalized ASO in 10 months for a young girl with Batten disease, a rare and fatal neurodegenerative disorder. The treatment was dubbed milasen, after the patient, Mila. It was the first medicine that was tailor-made to treat a single patient’s genetic mutation. The treatment temporarily improved Mila’s condition and quality of life, but ultimately, she died in February 2021 at 10 years old.

“The superpower of Crispr base editing is its broad applicability to many types of genetic mutations. Its kryptonite is that we are in the very early days of demonstrating efficient and safe Crispr delivery to many different organs,” Yu says. ASOs, meanwhile, are well vetted for use in the brain, spinal cord, and eye, which are more difficult to address with Crispr.

Crispr could potentially address a variety of genetic diseases and types of cancer, but getting it to the right place in the body remains a challenge. The approved Crispr medicine, Casgevy, involves removing a patient’s cells and editing them outside the body, an arduous and expensive process. A drug given directly to the body would be much more practical. The liver is an easy first target because lipid nanoparticles naturally gravitate there, but only some diseases can be treated in this way.

Since urea cycle disorders primarily originate in the liver, they could be a prime target for custom Crispr medicines. “We’ve just written a new playbook,” says Fyodor Urnov, scientific director at the Innovative Genomics Institute at UC Berkeley, who collaborated on the paper.

Urnov says KJ’s case demonstrates that bespoke genetic treatments can be made quickly and used successfully to treat critically ill patients. “This could have failed in so many ways,” he says. “Nothing was a given.” Every day, he worried that KJ would pass away before they could finish making the therapy.

The team did not say exactly how much the therapy cost to produce, but Musunuru says it was comparable to the cost of a liver transplant, around $800,000. The companies involved in manufacturing—Aldevron, Danaher, and Integrated DNA Technologies—made in-kind contributions.

“Though it will take a lot of work to get there, my hope is that someday no rare disease patients will die prematurely from misspellings in their genes, because we'll be able to correct them,” Musunuru says.

[scientia-rex]

What caused you to choose family practice after med school? What different specialties did you consider?

I kind of always knew--I started out before I knew anything thinking I wanted to specialize, maybe neurology given my history with Neuroscience, but once I shadowed a couple of doctors I was like "Oh. Family Medicine. That's what I like."

It's got a little bit of everything, it's impossible to be truly good at--I'm constantly forced to learn new things about every specialty because out here we have no one. I need to be half a nephrologist, half a rheumatologist, half a dermatologist. I do a crap ton of procedures--I like them, I like the satisfaction of an IUD insertion or a cyst removal done well. I will stay busy forever. I will never have a chance to get bored. I can do migraine care, manage Parkinson's, diagnose dementia, remove some skin cancers, differentiate between polymyalgia rheumatica and statin rhabdo--if I wanted to, I could still be doing hospital care, I could still be delivering babies. I have so many patients who either don't want to or can't drive two hours to the closest city for specialty care, and if I don't learn this, fast, and well, they'll get nothing. So there's always a fire under my ass. Rare genetic blood disorder? Shit! Read up! Molar pregnancy? I've seen two. Rural medicine is fucking wild and it's my happy place.

I recommended reading Med School Confidential for a better handle on a lot of this.

[fefe-the-cat]

⚠️TAKING OFF FILTER PLEASE BE NICE IM LOWKEY SCARED TO POST THIS ⚠️

KOTLC thoughts/ideas/questions:

•Can they have congenital neurodivergence (as opposed to personality disorders [often a result of adverse childhood experiences] or TBI impacts [Mrs. Redek can confirm a bad hit to the head can cause mental health issues] or shattering)? Before you come after me, I am neurodivergent and as far as I know, the subject of things like ADHD/autism is only really mentioned as Sophie wondering if the Ability Restrictor functions like an ADHD simulator and we know elves and humans have significant differences. For example, elves have more emphasis on the brain but not as much emphasis on mental health. We also know they can deliberately regulate their body temperatures, suppress certain sensations such as hunger, and they pop out of the womb completely fluent in the Enlightened language.

•This may be a bit strange, but seeing as this is being posted on Tumblr… I just need to know if elves menstruate. They definitely have reproductive differences. Pregnancy is immediately obvious and childbirth is no more than a little uncomfortable. Multiple births are rare to the point of prejudice towards the babies. But we also know they’re not SUPER biologically different from humans or other organisms, really: they have toilets and defecation is mentioned. Also, Sophie’s biological (not necessarily neurological; developed several special abilities, one of which at the age of five) development was relatively normal. If elves don’t need toilets, there would have been major medical concerns. But I digress. Elf periods: do they exist and are they any worse than human periods?

•theory: elves and humans are actually the same species but they’ve been separated for so long that they just aren’t super genetically similar anymore. But we know they look like humans. So theoretically…

•Can a Pyrokinetic and a Talentless match?

•kotlc animated series. I’m reading the books but I am SO TEMPTED to write a script and stuff

•Gowns actually are empowering. They got that right

•theory: humans might be able to live as long as elves but we have toxic chemicals and no Youth so we age and stuff

•someone is going to learn about the French Revolution and kill the council. I can feel it.

•Would a young Pyrokinetic get in trouble for just looking at the fire? I feel like Kyrelle would just stare at her little fireball (top thought needs answer because it may be visual stimming)

[rollingblakely]

Hey there, welcome to the chaos. ✨I'm disabled, chronically ill, neurodivergent, and proudly intersex—and if you're any of those things too, I hope you feel seen here. 🫶🏻

Dynamic As Hell 😎

I'm an incomplete paraplegic with dynamic disabilities-meaning some days I can pivot off a foot with assistance, and other days I can't scoot myself up on the couch because my arms are like "bestie no." | use a manual chair with power assist when I can and a power chair when I can't. (Shoutout to my Quantum Edge 3-coming soon to a hallway near me.)

My very unsexy but educational medical resume:

Congenital Myasthenic Syndrome (CMS): A rare neuromuscular disorder where my muscles and nerves straight up ghost each other, causing muscle weakness, loss of sensation, fatigue and joint subluxations (my joints out here freelancing).

Glycogen Storage Disease: My body stores energy like a toxic ex- inefficiently and with long-term consequences.

Dysautonomia (IST): My heart rate is the only thing about me that knows how to hustle.

Also living with: ME/CFS, cluster headaches (ow), fibromyalgia, incontinence (fun!), Hashimoto's, skeletal abnormalities in my spine (lost the genetic lottery) and chronic pain so consistent it's basically a roommate.

Intersex + Gender Is A Journey, Baby! 😮‍💨

I'm intersex and nonbinary, a proud blend of both. l've had male characteristics since I was 9, and when I got my medical records as an adult, I learned my original birth certificate just said "O." I don't fit in any binary box-so I don't try to. I'm both. I'm neither. I'm a little beard, a little glitter, and a lot of "what gender feels correct today?" I never know if I'm gonna wake up feeling like a glam queen or an Adam Sandler character. Either way, I always slay. 😉

Raw Dogging Mental Health:

I'm healing out loud after a childhood of abuse that started at 9 that contributed to my C-PTSD, ADHD, OCD, autism spectrum disorder, and agoraphobia.

I can't take SSRIs, atypical antidepressants, or antipsychotics due to my conditions and genetics-so l'm rawdogging my mental health journey and somehow thriving anyway?!? 👀

I'm at the gym 3-4x a week (yes, even in a wheelchair-accessibility is radical), exposure therapy, shadow work, and finding the delicate balance between respecting my body's limits and pushing through executive dysfunction. I’m unlearning all the cruel ways of thinking my parents taught me growing up, and learning to be comfortable with being uncomfortable. Some days the healing looks like deep inner work. Some days look like watching reality TV and crocheting until mv hands cramp.

It's messy. It's magical. It's all mine.

Breaking News: There’s No “Bad” Foods After All.

I'm healing my relationship with food. After years of chaos and a major health crash last year, I've lost 80 lbs total-12 of those since getting back on track. Now that my partner is my legal caregiver, l've got the support I need, and my body finally feels like it's starting to work with me, not just against me. I'm not chasing thinness-I'm chasing peace when I make a meal or shop for groceries.

My Little Joys

• Crochet: If it's practical, chunky, or a granny square, l'm in. Currently obsessed with amigurumi but forever starting five new projects before finishing one.

• Reality TV: Yes, I watch 1000lb Sisters, Teen Mom, and Sister Wives. No, I will not apologize. The tea is PIPING. ☕️🐸

• Financial Literacy: My partner and I watch Caleb Hammer while eating dinner. We paid off $10k in debt last year, and now that I have been approved for SSDI I'm able to support myself for the first time in years-and it feels so damn good.

• Art + Gaming: I love painting, drawing, and chill cozy games on the Switch (Paleo Pines, Cozy Garden, anything where I can grow fake plants and pet fake cows).

• Music: Raised by my grandparents = 60s-80s classics. Mom gave me 90s-2000s R&B/pop. Godfather gave me Latin music. Stepdad gave me Bob Marley. Theater kid brain gave me musicals. If I'm conscious, music is playing.

This space is for disabled joy, queer magic, healing energy, and a lot of chaos. Hope you’re hungry, cause baby I’m serving. 💖

[astraea802]

Merlin Rewatch 2x05

Something interesting I've never caught before about Lady Catrina - the real Lady Catrina, not the troll who impersonated her - is that she had "an incurable bone disorder that affected her joints".

In modern terms, the real Lady Catrina had a chronic illness and seemingly chronic pain, but it wasn't something that was publicly known since Uther, who apparently knew Catrina and the House of Tregor well, had no idea until Gaius, the court physician, told him. Yet Gaius first realized something was off because Troll!Catrina walked normally, so it must have affected her gait enough that a physician would notice but not someone who was unaware of the condition. Then again, perhaps Gaius was expecting the condition to have worsened with age, and when it didn't he became suspicious.

Like with discussion around what disease Tiny Tim might have had in A Christmas Carol, I wondered what disease Lady Catrina might have had. Not a terminal one apparently since Gaius didn't say the disease would kill her, and not one that stopped her from riding, just that made riding uncomfortable.

Some contenders:

Skeletal dysplasia: A category of rare genetic disorders that cause abnormal development of a baby's bones, joints, and cartilage. However, it might have been more physically obvious if this was what she had, so I'm not sure.

A bone or joint infection contracted as a child. Modern treatment involves antibiotics, something that would be unavailable in Catrina's time, so it's likely such an infection would weaken her for the long term.

My first thought was actually Ehlers-Danlo Syndrome, but it only affects the joints, not the bones, so that seems out.

But overall, it does sort of make me sad that, as caught up as we get in the gross troll antics of the "Beauty and the Beast" two-parter, there's this background tragedy about Lady Catrina and the fallen House of Tregor that the troll capitalized on that gets overlooked. You can almost (almost) see why Uther gets so concerned about Camelot maintaining its strong defenses at all costs when stuff like this happens to the kingdoms around them.

[nunalastor]

(Reply to the cursed webbed hooves incest ask from a few days ago)

When occurring alone without any other disorders/syndromes, syndactyly (webbed toes/fingers) is always autosomal dominant, meaning that it cannot be inherited through a parent which doesn't have it. We know that Charlie doesn't have it, but since we've never seen Luci's feet, he could have webbed feet/hooves, which would be really cute if he did. But in that case, the syndactyly wouldn't be caused by incest, but rather by one of the parents already having the genes and simply passing them on.

Inbreeding is dangerous specifically because family members tend to carry the same (potentially dangerous) recessive alleles due to them being closely related and likely receiving them from the same person. Some of these recessive alleles might be deleterious mutations, which are the reason why incest is so infamously associated with health problems.

The most simple genetic model to explain how this works is Mendel's Punnett square (I recommend googling this to visualise), which goes as follows: 2x dominant alleles result in offspring with a phenotype (visible characteristics) of the dominant allele (genotype AA), and 2x recessive alleles result in offspring with a phenotype of the recessive allele (genotype aa). It gets more interesting when putting together 2 people with each 1 dominant and 1 recessive allele (genotype Aa), this results in 75% offspring of the dominant phenotype (genotypes: 25% AA and 50% Aa), and 25% of the recessive phenotype (genotype aa).

In this case, syndactyly is caused the allele A (simplified for the sake of this fucking post), meaning that AA or Aa genotypes have the syndactyly phenotype, a.k.a. people with these genotypes have webbed fingers or toes. People who don't have syndactyly have an aa genotype, meaning that they also cannot pass on a syndactyly allele to their offspring.

Since syndactyly is caused by a dominant gene, it isn't and cannot be caused by inbreeding outright.

You might have noticed that I explicitly talked about syndactyly separate from any other disorders/syndromes. Well, that is because syndactyly can also be a symptom associated with a number of rare conditions. I'm not going to list all of them because there's a lot, but what you need to know is that its most commonly associated condition is none other than Down's Syndrome, which is believed to be caused by chance alone. Said chance increases as the parents age, but it is not inherited, and its chances of occurring are probably not increased via inbreeding.

With most of these other disorders, it is quite apparent if one has it, therefore we can safely say that neither Charlie or Luci have such a condition. And since most of the other conditions are dominant, which means that we can skip these since the argument has already been made.

However, Carpenter Syndrome, Filippi Syndrome, Fraser Syndrome, and Smith-Lemli-Opitz Syndrome are all autosomal recessive conditions which might have syndactyly as an additional symptom. But if you take a look at what the other symptoms of these conditions are, you'll find that syndactyly is the least concern. Hypothetically the frequency at which these conditions occur could be increased via inbreeding due to (once again) recessive alleles coming together, but because of their rarity, we know very little about these conditions and how they are inherited as of now. The initial cause cannot be properly traced back to form a proper conclusion. And I couldn't find any studies that discussed any of these conditions and the impact inbreeding has on them.

When not outright inherited from a parent, the remainder of these conditions are caused by various types of mutations, and contrary to popular belief; incest does NOT cause mutations, it simply makes it more likely for already existing mutations to cause problems because of recessive alleles coming together.

So no, Charlie and Luci's incest babies wouldn't have webbed hooves, and if they did, it would be because of sheer bad luck unrelated to incest, or because Lucifer already has them (which is now my headcanon).

Sources:

"Webbed Fingers" by Adrian E. Flatt (scientific article)

"Genetic Consultations in the Newborn" by Robin D. Clark and Cynthia J. Curry (book, specifically chapter 33 "Syndactyly")

I'd cite my sources better but it doesn't allow me to ask anonymously if I put in links :(

Also, I should probably mention that this post is not peer-reviewed. Let me know if I messed up somewhere xoxo

adding sources is crazy

[dreamsofalife]

((I need to make a new post about Shy and her animal symbols.

They're butterflies and deer, specifically piebald deer.

Butterflies are symbolic of hope, renewal, femininity, hope, and in many cultures around the world, are said to be the souls of the dead, come back to the world of the living.

Piebald deer are a bit more complex. Deer are symbols of grace, gentleness, innocence, as well as the untameable parts of nature. Some were said to be messengers for the fae, and deer are known to be both victims and vigilante in the cycle of nature. They're symbols of romance and courtship often, but also associated with the virgin goddess of the hunt, Artemis. Deer are, by nature, contradictory creatures. Timid, wild animals who are known for grace and gentleness but are more ferocious and tenacious than you'd ever imagine.

I chose piebald deer specifically because of a few things; they're sort of liminal, being in between normal deer and albino deer. They're valued and valuable... mostly to those who seek to kill them, or to protect them. They're extra contradictory.

I also chose a piebald deer because of their connection with childhood abandonment. Many mother deer will straight up leave piebald babies to die, due to them being easily spotted by predators, and because they often suffer from genetic disorders and die young anyway. It's rare as Hell to see a wild piebald reach adulthood. But, she's here. She's scared and wild, but she's here.))

[beepingmemesauce2727]

Plans for future Spidey-Villains if I were in charge of continuing The Spectacular Spider-Man.

Mac Gargan / Scorpion:

• Private Investigator hired by J. Jonah Jameson, like in the comics

• Fails due to Peter using his spider-sense to evade him, leading to him being fired by Jameson, which not only causes him to lose his job, but also leaves him homeless, but is offered a second chance by a man claiming to work for The Kingpin

• Registers for an experimental operation by Wilson Fisk and Alastair Smythe, the idea behind the operation being to essentially create a genetically-enhanced police officer

• He is injected with multiple steroids that enhance his physical strength, and his outfitted with bulletproof armor equipped with a cybernetic tail

• Same story as in the comics basically, he is sent to capture Spider-Man, but over time, the chemical augmentations start affecting his brain and drive him to insanity, leading him to paralyze Smythe, and attack J.J.J., Peter promptly defeats him

• Eventually joins a new version of the Sinister Six

Roderick Kingsley / Hobgoblin

• Perfume company CEO, wants to buy Oscorp, but Harry doesn't like him as he thinks Oscorp is the "Osborn Family Legacy", Roderick doesn't like Harry either, seeing him as a nepo baby, (which Harry kind of is)

• Has a twin-brother named Daniel, but is less successful than Roderick, leading to constant belittling by his older brother

• Secretly does shady business deals, like in Season 2 where he attended the auction with NYC's various crime lords

• Hires a spy to infiltrate Oscorp one night, that thug discovers the Green Goblin's tech, spy steals it and brings it back to Roderick

• Roderick sees an opportunity, and creates a new persona, The Hobgoblin, and learns that Osborn used performance-enhancers to gain his superhuman powers

• Creates a chemical compound that includes all of the effects of the original Globulin Green with none of the side-effects

• Roderick decides he can frame other people as the Hobgoblin so he can get away with his crimes scott-free and take control of Oscorp and expand his business

• Multiple people are framed for being the Hobgoblin throughout the third season, including Ned Leeds, Harry Osborn, Emily Osborn, J. Jonah Jameson, and even Roderick's own brother Daniel

• Enters a turf war with Wilson Fisk

• Eventually, Roderick is outed as the Hobgoblin, and is imprisoned

Art by TheJikaruss on Deviantart

Micheal Morbius / Morbius the Living Vampire

• Born in Greece in 1939, raised in America

• Was raised by his single mother, his father left his mother before he was born

• His mother died of a rare illness which caused her blood cells to rapidly degenerate, and eventually, Michael develops this disorder as well

• He meets Emil Nikos, and they become best friends, Nikos finds out about Michael's condition and vows to help him create a cure

• They won a Nobel Prize for their achievements in hematological research, and used the money to conduct the experiment that would cure Michael of his condition in 1971

• The experiment involved injecting Michael with a serum derived from the DNA of vampire bats, and electroshock therapy to enhance Michael's mutated blood cells

• The experiment goes awry, and Michael is transformed into a hideous creature resembling a vampire

• Michael kills Nikos in a bloodthirsty rage, and only regains his senses when he has completely drained Nikos of his blood

• Wracked with immeasurable guilt, Michael attempts suicide, but saves himself as living is a habit

• He roams the world for decades, eventually stumbling upon the house of Curt and Martha Connors, who he attacks while Peter is on a school field trip to the Florida Everglades

Morris Bench / Hydro-Man

• Demolitions expert, as he is in the show

• His wife divorced him a few months prior to the series, so he's a bit depressed

• He is brought to an experiment taking place on a cargo ship overseen by Oscorp, where there are experimenting with a device that can filter out hazardous chemicals in the world's various oceans

• The ship is attacked by the Hobgoblin, who is trying to steal technology, a fight breaks out between Spider-Man and Hobgoblin, and in the scuffle, Morris is knocked overboard

• Morris' body reacts strangely to the generator's radioactive materials, which causes his body to break down and then reform itself into a body that can transform itself into living water

• Hydro-Man escapes the hospital he was held in, and runs into the Hobgoblin, who convinces Morris that Spider-Man is responsible for his condition, and Hydro-Man swears revenge against the web-slinger

• He battles Spider-Man, who defeats him by freezing him with liquid nitrogen, and handing him over to the NYPD

• He is imprisoned, but eventually thawed out to join a new version of the Sinister Six

Cletus Kasady / Carnage

• Cletus is revealed to be a serial killer like in the comics

• He was born to Roscoe and Louise Kasady, and after he tortured and killed his mother's dog, he was sent to the St. Estes Home for Unwanted Children

• After he burned down the orphanage and killed the staff and its students, he murdered his parents as revenge for locking him up in that hell-hole

• He went on to murder several more people, until he was arrested, where the judge labeled him insane and had Cletus sent to the Ravencroft Institute for the Criminally Insane, where he "befriended" Eddie Brock

• After the Venom Symbiote returns to Eddie in his and Cletus' cell, Eddie turns into Venom and causes a break out

• Little did Eddie know, the symbiote had produced an offspring, and it bonded to Cletus' bloodstream, turning the symbiote red and giving it full control over Kasady's cellular structure, making him much stronger than Eddie and Venom

• Cletus became Carnage, and resumed his killing spree, but on a mass scale, turning anyone in his way into his symbiote possessed minions

• Spider-Man realizes he has no choice but to team up with Venom. He also joins up with Black Cat, Cloak & Dagger, Morbius, Sandman, Prowler, and Silver Sable to take down Carnage and his drones

• Carnage is eventually defeated, and the symbiote hordes are returned to normal

• Cletus is imprisoned by S.H.I.E.L.D., due to the catastrophic event he just caused, and that's the last we ever see of Carnage

• Or is it?

Hobie Brown / Prowler

• He becomes friends with Peter in Season 3

• He has a bone to pick with Harry Osborn due to his doping in Season 2

• However, his girlfriend Mindy McPherson is kidnapped by the Hobgoblin's men, and he takes matters into his own hands

• He dons the Prowler suit for the first time, and takes out mutiple caches of Hobgoblin's goons throughout the city in order to get to Mindy

• He runs into Spider-Man, and they get into a disagreement on how to take down The Hobgoblin, Peter just wants to simply defeat Hobgoblin and bring him to justice, whereas Hobie wants to kill Hobgoblin, and they get into a fight

• They eventually stop fighting, and put their differences aside to save Mindy

• They defeat Hobgoblin and his men and save Mindy, but Hobgoblin escapes before he can be arrested

• Prowler eventually teams up with Spidey again during the "Maximum Carnage" event

John Jameson / Man-Wolf

• Still in Ravencroft after Season 2

• He's still obsessed with the strength he obtained during his time as Colonel Jupiter

• He is visited in his cell by J.J.J. and Miles Warren, who offers to give him back the power he so desperately wants

• He is injected with a steroid that turns him back into Colonel Jupiter, and he becomes an ally to Spider-Man again

• Warren secretly installed nanites into John's bloodstream that would activate under lunar rays

• During one night out on patrol, John keeled over in pain and transformed into a hulking canine creature dubbed The Man-Wolf

• Man-Wolf eventually attacked his father at the DB, but Spider-Man used an antidote on John that eliminated the nanites in his system and turned him back into a human

• John was eventually turned back into Man-Wolf, and kidnapped by Kraven the Hunter and forced to fight Spider-Man again during this show's adaptation of "Kraven's Last Hunt", (Man-Wolf takes the place of Vermin) but after Kraven dies, Spider-Man goes after Man-Wolf and turns him back into a human again

• Warren finds a strand of Man-Wolf's hair, and keeps it along with a sample of Globulin Green...for safe keeping

Prof. Miles Warren / Jackal

• He's taken Dr. Connors' place as ESU's science division

• He has an assistant named Debra Whitman

• He was behind Molten Man and Man-Wolf, and will be the ultimate mastermind behind the Clone Saga

• He creates a clone of Peter and Gwen, the Peter clone is used to tarnish Peter's reputation as Spider-Man, while the Gwen clone would become Miles' surrogate daughter

• Miles' wife and daughter died prior to the series in an accident, and Gwen reminded him of his daughter

• So that when she died, Miles had a mental breakdown and decided to use his expertise in cellular biology to create a perfect clone of Gwen

• But Peter and his clone eventually put aside their differences, and confronted Miles in the ESU lab

• As a last resort, he injected himself with a serum comprised of canine DNA and Norman Osborn's Goblin serum, turning him into a monster called The Jackal

• He's eventually defeated, imprisoned, and returned to his human form after a vicious fight with Peter Parker and Ben Reilly

• He later escapes prison and creates a newer, stronger clone he calls Kaine, he brainwashes Kaine and sends him after Peter and Ben

• Kaine is eventually freed from his brainwashing and kills Miles for all the people he's hurt, Peter, Gwen, Curt Connors and his family, Mark Allan, and John Jameson

Art by Lunamidnight1998 on Deviantart

Martin Li / Mr. Negative

• Was experimented on by Wilson Fisk's head scientist, Dr. Jonathan Ohnn, and was imbued with Light & Darkforce powers

• Runs a soup kitchen with Aunt May and Nathan Lubensky called F.E.A.S.T.

• Secretly a crime lord called Mr. Negative and forms a group called the Inner Demons

• The experiments by Dr. Ohnn also created Cloak & Dagger

• Becomes the third wheel in The Kingpin and Hobgoblin's Turf War

• Eventually depowered and redeemed

Thank you for reading! :)

[andthe-damned]

stupid pet peeve but like you’ve watched one video or follow one account about a disorder that doesn’t make you the expert. This lady with a little kid is talking about her kids health struggles she had when she was a baby that she has overcome and not asking for any opinions or advice strictly sharing the story and all the comments are “she looks like she has sanfillipo syndrome” “have you had her tested for sanfillipo syndrome”

Like dude the mom literally NEVER mentioned her child having a single symptom of sanfillipo maybe don’t armchair diagnose her child with an incredibly rare terminal genetic disorder? Maybe you DONT need to comment on a child’s appearance especially to say you think they look abnormal?