#Prion Virus

[funky-gobbo-art]

Day 19. Disease

"Looks like the poor thing got mauled and it's still going."

[albino-parakeet]

Last Line Game

Rules: in a new post, show the last line you wrote (or drew) and tag as many people as there are words (or as many as you feel like).

Thank you so much for the tag @desfraisespartout !!!

I was actually trying to write something when I got the notification lol.

Listen I am not a writer so this probably isn't the best. 😅 It's mainly just descriptions.

The sour smell of mold eating away at any exposed surface, slowly encroaching through out the skeleton of an isolated wing. It’s doors barred shut from the main body of the building, wooden boards haphazardly nailed in place showing its age with their splintering grain. The tile, once spotless and waxed, now broken and crunch under each foot fall. 

Deep clean sanitation chambers, revered for their excellent sterilization, harbor clouds of spores from the trapped moisture. Glass panels looking into the main room, all smashed long ago, long since dried blood littered what remaining shards still stood on the frames edges. Thin streams of rainfall finding its home in the crevices of high tech computers and machines left to rust away in the humid tropical weather.

Memories of snarling teeth and rotten meat still connected to something living. Loud screams and festering wounds, desperate pleads for help to no avail. Quick claws and cut lines. All still haunt the one remaining occupant of this rotting corpse that housed the products of genetic achievements. A single soul slinking through the backdrop of this waking nightmare

No clue if there is anyone I can tag but whoever is interested can participate!

[an-organized-confusion]

Because med nerd (and watching a video about BSE)...

So. I called the zombie infection in the iZombie AU “ζvCJD-21“.

Just to break that down - the “vCJD“ part is named after “Variant Creutzfeldt-Jakob disease“ AKA “mad cow disease“.

“ζ“ is the lowercase Greek letter “zeta“... because zombies.

Aaand I think you get the naming convention behind the “...D-21“ part. (Outbreak was discovered that year, in this AU.)

But circling back on the main chunk... something I’ve HCd about the zombie infection here... is that if there is a cure to the infection, that it would still leave a sort of spongiform pattern of permanent damage in the brain. But here, specifically, the parts that process taste/smell. (Some can be compensated from rewiring/plasticity, but not 100%.)

(Though if the zombie progresses past Full Romero, the damage is more... diffuse and everywhere. If they stay fed, the agent behind the infection is stopped/slowed from progressing.)

If Logan has the opportunity to do autopsy on a zombie - that can be the histological findings (under the microscope) in their brain tissue.

(Just thinking of the implications for Team Z here - Janus, Virgil, the twins... and later, unfortunately, the twins’ parents.)

[naciapiracia]

i just had this dream where i was playing plague inc (the cure mode) with 2 other people. and these people were like. a team. i didnt have a team. it was vaguely like the cooperation mode (as in both players had separate funds but we could buy upgrades to the same thing??) but also not (because im cooperation i think you still have separate diseases, they just work together so to speak. i havent played cooperation in cure mode though)

these other people bought some stuff, ran out of funds, and gave me the laptop. i bought some upgrades including one that vaguely sounded like something zombie-related. i started infecting people in new zealand with something dark blue and i was so curious to see where this would go but alas i had to wake up at that point

[scientificinquirer-blog]

DAILY DOSE: Researchers intentionally infect patients with Zika; Ancient winemaking discovery.

GROUNDBREAKING OR QUESTIONABLE? In a pioneering effort, scientists have intentionally infected individuals with the Zika virus to ascertain its potential in aiding vaccine tests against the pathogen. The study, which saw only mild symptoms in participants, highlighted the promise of ‘human challenge’ initiatives, where volunteers are exposed to pathogens under controlled conditions, especially…

[ernestocamachopuga]

Una decisión sencilla y lógica

"Estimados miembros de Akasha Comunidad:

En 1976, al Dr. Gajdusek le fue otorgado el Premio Nobel por sus estudios hacia lo que él denominó 'virus no convencionales', que abarca a sus investigaciones con la enfermedad del Kuru y Scrapie. De hecho, se equivocó, ya que no se trata de enfermedades asociadas a virus, sino a priones, y su archienemigo Stanley Prusiner, obtuvo el premio Nobel en 1997 por describir a estos antes desconocidos agentes infecciosos: proteínas infecciosas, de ahí su nombre "prion" (abreviatura del inglés 'proteinaceous infectious particle' (https://www.science.org/doi/10.1126/science.6801762) y asignarles la causalidad a enfermedades como Creutzfeldt-Jakob, enfermedad de las vacas locas, Scrapie y Kuru.

Todas estas enfermedades se caracterizan por ser ocasionadas por proteínas cerebrales anárquicas, que se rehúsan a doblarse adecuadamente, y que, además, inducen a otras a cambiarse de forma, con lo que ocasionan daño en el cerebro por muerte neuronal que acaba generando una apariencia de cerebro de esponja (de ahí el que se llamen encefalopatías espongiformes). Es tremendo lo que eso implica, porque no se trata de una bacteria, hongo o de un virus, es decir, de algo externo que puede llegar a interactuar de forma antagonista con nosotros. En esta ocasión se trata de proteínas nuestras, es decir de algo que nosotros mismos generamos; de algo nuestro. Y, al ser algo nuestro, lo primero que implica es que no generamos una respuesta inmune contra los priones (recuerden que la respuesta inmune se da justamente porque reconocemos lo propio de lo ajeno, y en este caso, no es una proteina foránea; es nuestra, solo está doblada de forma diferente). Justamente, las enfermedades priónicas se caracterizan por no generar ninguna respuesta inflamatoria, ni anticuerpos ni nada (https://pubmed.ncbi.nlm.nih.gov/10900153). ¡Una ausencia total de respuesta en contra! 

Si quieren saber más sobre priones, pueden ver la clase correspondiente del curso de Virología (https://t.me/akashacomunidad/632). 

En mensajes previos ya he explicado que algunas partes (dominios) de la proteína Spike son tipo priónicas (https://pubmed.ncbi.nlm.nih.gov/35208734, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551214). De hecho, son los únicos Coronavirus que tienen esos dominios tipo priónicos, lo que resulta, digamos, inusual, ya que ni siquiera su 'hermanito' SARS (el que se describió en 2003), que usa el mismo receptor, tiene esas características priónicas en Spike.  ¿Qué quieren que les diga? ¿Cosas extrañas en este mundo pandémico? El caso es que Spike tiene estas regiones con características priónicas en la subunidad S1. 

Entonces, no tiene que sorprendernos que haya gente que ha desarrollado enfermedad priónica luego de exponerse a Spike (https://www.authorea.com/users/455597/articles/582067-sars-cov-2-spike-protein-in-the-pathogenesis-of-prion-like-diseases). Se ha reportado para un par de pacientes que se habían infectado de SARS-COV-2 (por ejemplo, https://www.tandfonline.com/doi/full/10.1080/19336896.2022.2095185), pero es poco probable que ocurra. ¿Por qué? Pues, porque el virus no suele entrar al sistema nervioso central. Sin embargo, en un inoculado, sabemos que sí se puede distribuir el ARNm sintético (Pfizer y Moderna) o el vector adenoviral (AstraZeneca, Jansen, Cansino, Sputnik) al cerebro, y como producen Spike las células en las que entra y durante bastantes semanas, existe la posibilidad de que se expongan las proteínas cerebrales a las regiones priónicas de Spike. Y si esto ocurre, existe a su vez la posibilidad de que inicie una enfermedad priónica. Aclaro, no pasaría en todos, por supuesto que no, pero es una posibilidad que no puede excluirse.

Ya se han reportado casos de enfermedad priónica post inoculación contra COVID (https://scholarlycommons.hcahealthcare.com/internal-medicine/420, https://jag.journalagent.com/z4/vi.asp), incluyendo uno escrito como carta al editor por Yüce Doğru y Sezgin Kehaya (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469682).

—

No se trata de alarmar ni sembrar miedo, pero tampoco sería responsable ignorar el conocimiento que está demostrando la plausibilidad causal de estas inoculaciones con enfermedades neurodegenerativas que, al menos con medicina convencional, no tienen cura alguna (https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(22)00083-7/fulltext).

Qué curioso y qué irónico resulta que por intentar (fallidamente, porque no funciona ni para eso) evitar contagiarse de un virus que provoca un cuadro similar a un resfriado, que tiene una tasa de letalidad promedio menor al 0.003% (https://www.sciencedirect.com/science/article/pii/S001393512201982X), para el que hay tratamientos sencillos y seguros y contra el que generamos inmunidad amplia y efectiva de forma natural, se aplique la gente un producto que carece de certezas de seguridad, que no funciona (por algo van en la quinta dosis... ¡vaya efectividad!), y que tiene como riesgos, entre otras cosas, la posibilidad (baja, tal vez, pero real) de desarrollar una enfermedad neurodegenerativa contra la que no hay cura. ¡Una ganga!, dirán los médicos (y dentistas) influencers.

Mi respuesta: Les regalo las cinco dosis (o las que el Gobierno haya contabilizado para mí) si las desean. Yo sí he leído la literatura científica más allá de los panfletos médicos y propaganda, sé hacer análisis de riesgo beneficio, y tengo sentido común. Y, ¿ustedes?

Les mando saludos, Karina AW"

[macgyvermedical]

Incubation Periods List

Hi all!

The following is a list of incubation periods for various infectious diseases for all your writing needs. An incubation period is the amount of time between exposure to an infectious agent (bacteria, virus, protozoa or prion) and the person having the first symptoms of the resulting illness. Knowing this is helpful in creating a timeline for your story.

Anthrax: Incubation period of 1-60 days

Avian Flu: Incubation period 3-9 days

Botulism: Incubation period 12-72 hours

Chikungunya: Incubation period 3-7 days

Chlamydia: incubation period 7-21 days

COVID-19: Incubation period 5-10 days

Creutzfeldt-Jacob Disease: Incubation period 10-20 years

Dengue: Incubation period 5-7 days

Diphtheria: Incubation period 2-5 days

Ebola: Incubation period 2-21 days

Hantavirus: incubation period 1-8 weeks

Hepatitis A: incubation period about 28 days

Herpes: Incubation period 2-12 days

Herpes Zoster/Varicella (Chickenpox): Incubation period 14-16 days

Herpes Zoster (Shingles): Incubation period- technically none, as this is a reactivation of the virus that causes chickenpox

HIB: Incubation period 2-10 days

HIV: Incubation period 1-6 weeks to prodrome, approximately 10 years to AIDS

Influenza: Incubation period 1-4 days

Legionnaires Disease: Incubation period 5-6 days

Leprosy: Incubation period 9 months to 20 years

Lyme Disease: Incubation period 3-30 days

Malaria: Incubation period 7-30 days

Measles: Incubation period 10-12 days

Meningitis, Bacterial: Incubation period 2-10 days

Meningitis, Viral: Incubation period 3-10 days

Monkeypox: Incubation period 1-2 weeks

Mumps: Incubation period 16-18 days

Norovirus: Incubation period 12-48 hours

Pertussis: Incubation period 7-10 days

Plague: Incubation period 2-8 days

Pneumococcal Pneumonia: Incubation period 1-3 days

Polio: Incubation period 7-10 days

Q-Fever: Incubation period 2-3 weeks

Rabies: Incubation period 20-90 days

RSV: Incubation period 4-6 days

Smallpox: Incubation period 7-17 days

Syphilis: Incubation period 10-90 days

Tetanus: Incubation period 3-21 days

Tuberculosis: Incubation period 2-10 days

Typhoid: Incubation period 6-30 days

Typhus: Incubation period 1-2 weeks

West Nile Virus: Incubation period 2-6 days

Yellow Fever: Incubation period 3-6 days

Zika: Incubation period 3-14 days

[the-seelie-court-official]

i know there can be some overlap between some of these options, but i think there's a different enough intent behind bio-weapon and virus that you gotta pick which one for reasons

i love zombie media, especially when certain tropes are present, but i dont wanna influence the poll too much. YOU should feel free to do so

[transmechanicus]

God that Tyranid computer virus irritates me so much. The Rain of Fire was already a grimdark Admech event (useful Tyranid tactics buried forever in archives). To go back to it and write it so that it has worse repercussions was unnecessary, it was already an obvious L. To have what is essentially a flash drive full of memories copy-pasted from Skitarii be corrupted by some kind of Tyranid thing spontaneously manifesting from nowhere is so stupid. How would storing audio, video, or images of tyranids create a computer virus, even if let’s say the flash drive is a mummified servitor brain?? That kind of “corruption by observation” is shit that daemons do using warp magic, to try and rationalize that for tyranids is idiotic to me as a bio-scientist. I take great joy in Tyranids doing crazy things like poisoning environments with bacteria, having flesh riddled with genestealer prions (that make you susceptible to the Hive Mind if consumed), or being able to psychically mutate their biology to overcome being lobotomized. All those things have a biological, rational explanation. There’s no biological mechanism to make snapping pictures of a carnifex into something hazardous to store as information. If there was, everyone who has ever fought or observed the tyranids would suffer from this virus. Deeply unserious concept.

[shadowsageingempress]

Akira Himekawa out here doing us all a favor.

The separation anxiety headcanon comes up pretty late in NoS, during the Zant battle. Basically as he’s teleporting Twi to various locations, he’s put Midna in a pocket dimension by herself and mocks her for falling in love with a human.

I also think Twi would also get scared/nervous whenever he’s apart from Midna.

Delivering the pages and context you asked for 🫡 can't send all of them because the images cap is silly, but this should cover most of it

Oh damn, this is so cool.

The way she goes absolutely feral when using the Fused Shadows is really cool, and goes to show how powerful her ancestor was. I like the idea that the longer she’s under their influence/in that form, the more she loses control of herself.

Once she’s back to normal, her apologizing to Twi for attacking him is also rather bittersweet, and shows that she does care about him.

And the way Twi not only forgives her immediately but defends her against his former allies just furthers this bond of trust and love.

Perfect.

[chaifootsteps]

Oh I also have an interesting idea for Alastor. It might sound ‘uncomfortable’ for some fans, but I find it to be a fascinating idea.

So there’s a thing that’s called ‘Chronic Wasting Disease’, and it effects deer, elk, and moose. It comes from the protein prion, and it’s very common in foods that deer/elk/moose eat. It effects the animals brains, such as drooling, stumbling, lack of coordination/energy, ears/head falling and drooping, frequently thirst, incredibly skinny(wasting), and shaggy fur.

Soo since Alastor’s a deer demon, I thought, why not make a mutated sort of disease in hell that can affect deer/elk/moose sinners??

It would be a cool twist to see the high and mighty Alastor becoming sick with a virus that infects demons like him, and is incurable

That would be pants-shittingly terrifying. Prison diseases are the stuff of nightmares.

[darkmaga-returns]

Everyone has heard the vaccine propaganda at least a hundred times because the vaccine industrial complex coined the term “herd theory,” and they shove it down everyone’s throats every time they come out with a new vaccine. There’s a massive logic breakdown though, with the “herd theory” concept and vaccine “efficacy” in general.

The entire purpose of getting a vaccine is to create immunity to a specific virus or infectious disease, but then, all the doctors and “disease experts” remind everyone over and over that the only way they work is if at least 80 or 90 percent of the population gets them. Come again?

Now imagine if we were all told that about vitamin C, that it’s completely useless if 9 out of 10 Americans don’t take any. Who would even believe that vitamin C helps boost immunity and protect against viruses? Who would bother?

For the rollout of Covid “vaccines” Fauci and his CDC goons told everyone we could “flatten the curve” of the pandemic if most Americans got injected

The vaccine lies are so bad, but still 270 million Americans rushed to the doctors, pharmacies and clinics to get their mass-sheeple injections because they fell for the fear-based scamdemic of the century. We all found out later that Covid barely kills anyone, especially healthy folks, young folks or babies.

We found out later that the Covid jabs don’t prevent infection, they just keep you from getting a “bad case” of Covid. But that was also a lie. We found out later that the vaccines don’t keep you from spreading Covid to others, but actually help you spread it through “shedding” the spike proteins.

In other words, no matter how many people got the shots, it didn’t matter at all. Even if every single American, including kids, babies and pregnant women, got the mRNA gene mutation stabs, it would NOT have helped stop the spread or infection of the Wuhan virus.

That’s why they had to create the fraudulent PCR tests, that signified anyone with any kind of bacterial or viral infection was “positive” for Covid-19. Sure. It was just another ploy to get everyone scared enough to go get injected with the deadly spike-prion-factory, self-assembling nanoparticle clot shots.

[dreamcast641]

Different kitties, different virus (and a prion)

TW FOR BODY HORROR BELOW

scp 610 the flesh that hates

SCP 217 the clockwork virus

scp 008 the zombie prion

scp 2450 teeth

yes ik its not all of them but i think the majority are just the famous ones soooo

[ottogatto]

after all the times i went back to play plague inc evolved, i think i'm going to buy my own copy. i remember once achieving bacteria, virus, fungus, parasite and simian plague, with only prion, shadow plague, necroa virus and nano virus left.

[localratwithcowboyhat]

Favorite Nuerological/muscle parasite

Mine is Toxoplasmosis (crazy cat lay virus) but Prions (Mad cow disease) comes in close second

Mine actually is mad cow disease!

[twistedwonderlandshenanigans]

World Building for Infection/Apocalypse AUS - A General Guide

okay so this isn't DIRECTLY related to TWST but I have a project that's been in the works for a while that I might MIGHT launch in January. I also can't claim that this information is 100% correct bc I largely did it off the top of my head (AS someone who is going to school to become a microbiologist/related fields) ANYWAYS enjoy. maybe. idk. I got disproportionately mad one day about some au that was switching between 'virus' and something else I can't even remember and went on a rant on discord that I'm just posting here

If anybody ever wants to write an infection au with science as a base.

Putting it under the cut in case it makes anybody uncomfy OTL (also mentions of cannibalism in the "Prion" section)

Bacteria are usually NOT the issue. Bacteriophages are viruses that infect bacteria, which then can infect us. There ARE some pathogenic bacteria without viruses. They are treated with antibiotics based on their cell morphology and structure. Most of the time, you can wait out a bacteriological infection, such as the common cold.

Symptoms can show up from anywhere between 12 hours to 6 weeks depending on what it is.

Bacteria are unlikely to be the cause of a zombie apocalypse, however vaccines against bacterial infections ARE possible, (but unlikely due to most bacterial infections simply "running their course"), and are easier to develop for bacteria rather than viruses. -------------------------------

Viruses are delivered in protein-covered capsules that interact with other cells in order to "open" it and release the infectious RNA into the healthy cell. (Essentially, it's a little dude with a hat that cells open a door to. Once they let the little dude in, little dude takes over and acts like an overbearing mother in law, rearranging everything until it's how IT likes it, and proceeds to brag about it to neighbours, making it a trend/passing it on.)

It's the protein cap/envelope that we develop vaccines for, at least in most cases.

If you want it to cause zombie-like attributes in terms of brain function, Encephalitis is a good place to start your research. (Viral infection of the brain that causes swelling and eventual cell death).

Symptoms typically become apparent within 2 days of infection.

If an apocalypse starts because of a virus, a vaccine WOULD be possible/likely. ANTIBIOTICS HAVE NO EFFECT ON VIRUSES. ------------------------

Parasites are typically found in the intestines, as they want to leech off of the nutrients you are supposed to be getting. (That being said, tapeworm has been recorded as having been found in the brain once or twice. Brother How. I don't know). That being said, being infected with that type of parasite would make you very hungry and very dehydrated, but these type are hard to pass on from person, unless you made it kind of like Alien where a big fucken worm goes into one person, lays eggs, those hatch and explode and spread to other people.

You could also draw inspiration from the creatures that cause Swimmer's Itch or Scabies, which infect the skin instead. VERY easy to spread, fairly easy to treat. Can be treated with something as simple as cold water, or medicated creams.

Not likely to cause an actual apocalypse, but a lot of fun creative freedom with these bitches.

-----------------------------------------------

Fungi can be used for a fun twist. MOST modern day zombie movies are inspired by the Ophiocordyceps unilateralis - the zombie-ant fungus. In a more general sense, fungal infections of the lungs are :sparkles: scary :sparkles:. Usually molds are inhaled. Molds can't thrive inside the body "as is", so they undergo transformation to essentially become a type of yeast. This means symptoms can take a WHILE to show up - anywhere from about three days to THREE MONTHS. Fungal infections also often resemble bacterial infections, making them more difficult to diagnose. The longer it's left to sporulate, the more it will target areas of the body - including the brain, the meninges, your bones, your joints, etc. If it reaches your brain, it can no longer be cured, but it can be managed with antifungal drugs.

However, fungal infections are not typically contagious, which is where the zombie ant fungus explains how to spread it ^^

The zombie ant fungus spores are inhaled, and instead of turning into a yeast, it grows out of the ants head ^^ After about seven days, it gives the ant a signal to position itself over it's colony, so when the mushroom releases it's spores, it has a myriad of hosts to infect!

Fungal infections would have no vaccine, and antibiotics would not work.. An Anti-fungal medication would have to be developed and administered early enough in contraction to prevent any serious long lasting effects.

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Prions are infectious proteins. They have no cap/envelope. Prions cause holes to form in the central nervous system, impairing judgement, coordination, etc. etc. They are very slow forming, as they often take years to develop. In cows they are the result of old age, in sheep, they are the result of genetic predisposition, in humans it was because of cannibalism! We don't know why they started. Prion infections occur when someone consumes infectious matter, which is limited to the CNS, or when contaminated surgical tools are used.

There is no cure or preventative measures for prion diseases.

Prions can only die if they are incinerated or in chemicals that are WAY too expensive for me to pronounce.

Obviously in an au, their development could be sped up.

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Honourable Mention: Viroids Viroids affect plants specifically as a short strand of circular RNA that is capable of self replicating. Unlike viruses, they have no protein cap or envelope, meaning they're susceptible to destruction and mutation from other genes. However, they cause major deformation as well as impeding functions of other genes in the plant. If it were to mutate to affect humans, it would likely contort us and affect our ability to metabolize food.

--------------------- :P I just wanted to feel like I did something this week, even though this is technically from like. 2 weeks ago. oh well