#Prion Virus

[funky-gobbo-art]

Day 19. Disease

"Looks like the poor thing got mauled and it's still going."

[i-spilled-my-soup]

could you draw plague!will?

i dont know what plague dude is supposed to look like or how he's supposed to work so you get biology and chemistry flashcards instead

[albino-parakeet]

Last Line Game

Rules: in a new post, show the last line you wrote (or drew) and tag as many people as there are words (or as many as you feel like).

Thank you so much for the tag @desfraisespartout !!!

I was actually trying to write something when I got the notification lol.

Listen I am not a writer so this probably isn't the best. 😅 It's mainly just descriptions.

The sour smell of mold eating away at any exposed surface, slowly encroaching through out the skeleton of an isolated wing. It’s doors barred shut from the main body of the building, wooden boards haphazardly nailed in place showing its age with their splintering grain. The tile, once spotless and waxed, now broken and crunch under each foot fall. 

Deep clean sanitation chambers, revered for their excellent sterilization, harbor clouds of spores from the trapped moisture. Glass panels looking into the main room, all smashed long ago, long since dried blood littered what remaining shards still stood on the frames edges. Thin streams of rainfall finding its home in the crevices of high tech computers and machines left to rust away in the humid tropical weather.

Memories of snarling teeth and rotten meat still connected to something living. Loud screams and festering wounds, desperate pleads for help to no avail. Quick claws and cut lines. All still haunt the one remaining occupant of this rotting corpse that housed the products of genetic achievements. A single soul slinking through the backdrop of this waking nightmare

No clue if there is anyone I can tag but whoever is interested can participate!

[an-organized-confusion]

Because med nerd (and watching a video about BSE)...

So. I called the zombie infection in the iZombie AU “ζvCJD-21“.

Just to break that down - the “vCJD“ part is named after “Variant Creutzfeldt-Jakob disease“ AKA “mad cow disease“.

“ζ“ is the lowercase Greek letter “zeta“... because zombies.

Aaand I think you get the naming convention behind the “...D-21“ part. (Outbreak was discovered that year, in this AU.)

But circling back on the main chunk... something I’ve HCd about the zombie infection here... is that if there is a cure to the infection, that it would still leave a sort of spongiform pattern of permanent damage in the brain. But here, specifically, the parts that process taste/smell. (Some can be compensated from rewiring/plasticity, but not 100%.)

(Though if the zombie progresses past Full Romero, the damage is more... diffuse and everywhere. If they stay fed, the agent behind the infection is stopped/slowed from progressing.)

If Logan has the opportunity to do autopsy on a zombie - that can be the histological findings (under the microscope) in their brain tissue.

(Just thinking of the implications for Team Z here - Janus, Virgil, the twins... and later, unfortunately, the twins’ parents.)

[thebeanestbad]

it’s the absolute last thing on my list of things to gripe about but. Descolada is not a fucking virus

[naciapiracia]

i just had this dream where i was playing plague inc (the cure mode) with 2 other people. and these people were like. a team. i didnt have a team. it was vaguely like the cooperation mode (as in both players had separate funds but we could buy upgrades to the same thing??) but also not (because im cooperation i think you still have separate diseases, they just work together so to speak. i havent played cooperation in cure mode though)

these other people bought some stuff, ran out of funds, and gave me the laptop. i bought some upgrades including one that vaguely sounded like something zombie-related. i started infecting people in new zealand with something dark blue and i was so curious to see where this would go but alas i had to wake up at that point

[scientificinquirer-blog]

DAILY DOSE: Researchers intentionally infect patients with Zika; Ancient winemaking discovery.

GROUNDBREAKING OR QUESTIONABLE? In a pioneering effort, scientists have intentionally infected individuals with the Zika virus to ascertain its potential in aiding vaccine tests against the pathogen. The study, which saw only mild symptoms in participants, highlighted the promise of ‘human challenge’ initiatives, where volunteers are exposed to pathogens under controlled conditions, especially…

[grison-in-space]

PRIONS. I agree: they are terrifying and bizarre and extremely cool! I am rather delighted to see this neat little compilation of Additional Prion Facts for perusal!

stop saying "cannibalism causes prion diseases" this is a common misconception

gonna preface this by saying I'm not trying to be weird or edgy here I just have an interest in diseases and find it frustrating to constantly see people spreading misinformation abt how they originate and spread

this misconception comes from an epidemic of kuru, a type of prion disease (you might also seem em referred to as TSEs) that broke out among the Fore people of Papau New Guinea in the 1950s. until colonial rule, the Fore people practiced a form of funerary cannibalism in which a loved one's flesh, including organs, would be consumed after they died. this practice isn't exclusive to the Fore, and has no profound inherent dangers; cooking and eating human flesh doesn't have any more health risks associated with it than eating the flesh of an animal. what started the epidemic wasn't the practice of cannibalism, but rather a stroke of incredibly, incredibly bad luck.

(more under the cut; there's cannibalism and disease talk, but nothing graphic.)

a prion disease is caused by infectious prions in the brain. this is a type of misfolded protein that can cause other proteins to become misfolded as well. the misfolding of these proteins results in a deadly neurodegenerative disease. CJD (creutzfeldt-jakob disease), one type of prion disease, is capable of spontaneously occuring in otherwise healthy individuals with no family history of the disease; this is likely what happened to one unfortunate member of the Fore community. most of the time, only contact with brain and spinal tissue transmit this prion disease, so the women and children who traditionally ate these tissues soon began to present symptoms of the disease. the rest is fairly self explanatory; the community has no experience whatsoever with the disease, so doesn't know how to stop the spread; the afflicted die, and when they are eaten, the disease spreads to a new set of people, they die, the disease spreads more, et cetera. this continues until the practice of funerary cannibalism is brought to an end, and the last known sufferer of the disease dies in 2009.

so there's a couple things to note here. firstly, CJD, the disease that likely struck the initial sufferer, is incredibly rare. it affects roughly one in a million people, and only 85% of these cases are the result of spontaneous generation. secondly, the only reason that it was able to spread to such a degree is because cannibalism was practiced regularly in this culture. to act as though any cannibalism (ESPECIALLY in a culture where cannibalism is not normal) will lead to prion disease is absolutely absurd. the likelihood of even encountering someone with a prion disease is wildly low, and even then, if the brain and spinal tissue are avoided, the disease most likely won't transmit between the consumer and the person being eaten.

ultimately, saying that cannibalism will give you a prion disease is as absurd as saying that going to the doctor for a blood transfusion is going to give you HIV. blood transfusion might be capable of spreading HIV, but in normal circumstances, this will not happen. there is nothing inherent to blood transfusion that causes HIV, just as there's nothing inherent to cannibalism that causes prion diseases. yes, cannibalism would most likely give you a prion disease; if you happened to live in a community that already regularly practiced cannibalism, where a prion disease was already running rampant. yes, cannibalism will give you a prion disease; if you happen to stumble into one of the one people per million who has one, fail to recognize a single symptom that might deter you, and then choose to eat brain or spinal tissue rather than meat.

once again, this isn't trying to be some weird edgy cannibalism joke, i just think it's important that people have an understanding of where diseases come from and how they spread. kudos if you read this whole tangent

[ernestocamachopuga]

Una decisión sencilla y lógica

"Estimados miembros de Akasha Comunidad:

En 1976, al Dr. Gajdusek le fue otorgado el Premio Nobel por sus estudios hacia lo que él denominó 'virus no convencionales', que abarca a sus investigaciones con la enfermedad del Kuru y Scrapie. De hecho, se equivocó, ya que no se trata de enfermedades asociadas a virus, sino a priones, y su archienemigo Stanley Prusiner, obtuvo el premio Nobel en 1997 por describir a estos antes desconocidos agentes infecciosos: proteínas infecciosas, de ahí su nombre "prion" (abreviatura del inglés 'proteinaceous infectious particle' (https://www.science.org/doi/10.1126/science.6801762) y asignarles la causalidad a enfermedades como Creutzfeldt-Jakob, enfermedad de las vacas locas, Scrapie y Kuru.

Todas estas enfermedades se caracterizan por ser ocasionadas por proteínas cerebrales anárquicas, que se rehúsan a doblarse adecuadamente, y que, además, inducen a otras a cambiarse de forma, con lo que ocasionan daño en el cerebro por muerte neuronal que acaba generando una apariencia de cerebro de esponja (de ahí el que se llamen encefalopatías espongiformes). Es tremendo lo que eso implica, porque no se trata de una bacteria, hongo o de un virus, es decir, de algo externo que puede llegar a interactuar de forma antagonista con nosotros. En esta ocasión se trata de proteínas nuestras, es decir de algo que nosotros mismos generamos; de algo nuestro. Y, al ser algo nuestro, lo primero que implica es que no generamos una respuesta inmune contra los priones (recuerden que la respuesta inmune se da justamente porque reconocemos lo propio de lo ajeno, y en este caso, no es una proteina foránea; es nuestra, solo está doblada de forma diferente). Justamente, las enfermedades priónicas se caracterizan por no generar ninguna respuesta inflamatoria, ni anticuerpos ni nada (https://pubmed.ncbi.nlm.nih.gov/10900153). ¡Una ausencia total de respuesta en contra! 

Si quieren saber más sobre priones, pueden ver la clase correspondiente del curso de Virología (https://t.me/akashacomunidad/632). 

En mensajes previos ya he explicado que algunas partes (dominios) de la proteína Spike son tipo priónicas (https://pubmed.ncbi.nlm.nih.gov/35208734, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551214). De hecho, son los únicos Coronavirus que tienen esos dominios tipo priónicos, lo que resulta, digamos, inusual, ya que ni siquiera su 'hermanito' SARS (el que se describió en 2003), que usa el mismo receptor, tiene esas características priónicas en Spike.  ¿Qué quieren que les diga? ¿Cosas extrañas en este mundo pandémico? El caso es que Spike tiene estas regiones con características priónicas en la subunidad S1. 

Entonces, no tiene que sorprendernos que haya gente que ha desarrollado enfermedad priónica luego de exponerse a Spike (https://www.authorea.com/users/455597/articles/582067-sars-cov-2-spike-protein-in-the-pathogenesis-of-prion-like-diseases). Se ha reportado para un par de pacientes que se habían infectado de SARS-COV-2 (por ejemplo, https://www.tandfonline.com/doi/full/10.1080/19336896.2022.2095185), pero es poco probable que ocurra. ¿Por qué? Pues, porque el virus no suele entrar al sistema nervioso central. Sin embargo, en un inoculado, sabemos que sí se puede distribuir el ARNm sintético (Pfizer y Moderna) o el vector adenoviral (AstraZeneca, Jansen, Cansino, Sputnik) al cerebro, y como producen Spike las células en las que entra y durante bastantes semanas, existe la posibilidad de que se expongan las proteínas cerebrales a las regiones priónicas de Spike. Y si esto ocurre, existe a su vez la posibilidad de que inicie una enfermedad priónica. Aclaro, no pasaría en todos, por supuesto que no, pero es una posibilidad que no puede excluirse.

Ya se han reportado casos de enfermedad priónica post inoculación contra COVID (https://scholarlycommons.hcahealthcare.com/internal-medicine/420, https://jag.journalagent.com/z4/vi.asp), incluyendo uno escrito como carta al editor por Yüce Doğru y Sezgin Kehaya (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469682).

—

No se trata de alarmar ni sembrar miedo, pero tampoco sería responsable ignorar el conocimiento que está demostrando la plausibilidad causal de estas inoculaciones con enfermedades neurodegenerativas que, al menos con medicina convencional, no tienen cura alguna (https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(22)00083-7/fulltext).

Qué curioso y qué irónico resulta que por intentar (fallidamente, porque no funciona ni para eso) evitar contagiarse de un virus que provoca un cuadro similar a un resfriado, que tiene una tasa de letalidad promedio menor al 0.003% (https://www.sciencedirect.com/science/article/pii/S001393512201982X), para el que hay tratamientos sencillos y seguros y contra el que generamos inmunidad amplia y efectiva de forma natural, se aplique la gente un producto que carece de certezas de seguridad, que no funciona (por algo van en la quinta dosis... ¡vaya efectividad!), y que tiene como riesgos, entre otras cosas, la posibilidad (baja, tal vez, pero real) de desarrollar una enfermedad neurodegenerativa contra la que no hay cura. ¡Una ganga!, dirán los médicos (y dentistas) influencers.

Mi respuesta: Les regalo las cinco dosis (o las que el Gobierno haya contabilizado para mí) si las desean. Yo sí he leído la literatura científica más allá de los panfletos médicos y propaganda, sé hacer análisis de riesgo beneficio, y tengo sentido común. Y, ¿ustedes?

Les mando saludos, Karina AW"

[macgyvermedical]

Incubation Periods List

Hi all!

The following is a list of incubation periods for various infectious diseases for all your writing needs. An incubation period is the amount of time between exposure to an infectious agent (bacteria, virus, protozoa or prion) and the person having the first symptoms of the resulting illness. Knowing this is helpful in creating a timeline for your story.

Anthrax: Incubation period of 1-60 days

Avian Flu: Incubation period 3-9 days

Botulism: Incubation period 12-72 hours

Chikungunya: Incubation period 3-7 days

Chlamydia: incubation period 7-21 days

COVID-19: Incubation period 5-10 days

Creutzfeldt-Jacob Disease: Incubation period 10-20 years

Dengue: Incubation period 5-7 days

Diphtheria: Incubation period 2-5 days

Ebola: Incubation period 2-21 days

Hantavirus: incubation period 1-8 weeks

Hepatitis A: incubation period about 28 days

Herpes: Incubation period 2-12 days

Herpes Zoster/Varicella (Chickenpox): Incubation period 14-16 days

Herpes Zoster (Shingles): Incubation period- technically none, as this is a reactivation of the virus that causes chickenpox

HIB: Incubation period 2-10 days

HIV: Incubation period 1-6 weeks to prodrome, approximately 10 years to AIDS

Influenza: Incubation period 1-4 days

Legionnaires Disease: Incubation period 5-6 days

Leprosy: Incubation period 9 months to 20 years

Lyme Disease: Incubation period 3-30 days

Malaria: Incubation period 7-30 days

Measles: Incubation period 10-12 days

Meningitis, Bacterial: Incubation period 2-10 days

Meningitis, Viral: Incubation period 3-10 days

Monkeypox: Incubation period 1-2 weeks

Mumps: Incubation period 16-18 days

Norovirus: Incubation period 12-48 hours

Pertussis: Incubation period 7-10 days

Plague: Incubation period 2-8 days

Pneumococcal Pneumonia: Incubation period 1-3 days

Polio: Incubation period 7-10 days

Q-Fever: Incubation period 2-3 weeks

Rabies: Incubation period 20-90 days

RSV: Incubation period 4-6 days

Smallpox: Incubation period 7-17 days

Syphilis: Incubation period 10-90 days

Tetanus: Incubation period 3-21 days

Tuberculosis: Incubation period 2-10 days

Typhoid: Incubation period 6-30 days

Typhus: Incubation period 1-2 weeks

West Nile Virus: Incubation period 2-6 days

Yellow Fever: Incubation period 3-6 days

Zika: Incubation period 3-14 days

[the-seelie-court-official]

i know there can be some overlap between some of these options, but i think there's a different enough intent behind bio-weapon and virus that you gotta pick which one for reasons

i love zombie media, especially when certain tropes are present, but i dont wanna influence the poll too much. YOU should feel free to do so

[transmechanicus]

God that Tyranid computer virus irritates me so much. The Rain of Fire was already a grimdark Admech event (useful Tyranid tactics buried forever in archives). To go back to it and write it so that it has worse repercussions was unnecessary, it was already an obvious L. To have what is essentially a flash drive full of memories copy-pasted from Skitarii be corrupted by some kind of Tyranid thing spontaneously manifesting from nowhere is so stupid. How would storing audio, video, or images of tyranids create a computer virus, even if let’s say the flash drive is a mummified servitor brain?? That kind of “corruption by observation” is shit that daemons do using warp magic, to try and rationalize that for tyranids is idiotic to me as a bio-scientist. I take great joy in Tyranids doing crazy things like poisoning environments with bacteria, having flesh riddled with genestealer prions (that make you susceptible to the Hive Mind if consumed), or being able to psychically mutate their biology to overcome being lobotomized. All those things have a biological, rational explanation. There’s no biological mechanism to make snapping pictures of a carnifex into something hazardous to store as information. If there was, everyone who has ever fought or observed the tyranids would suffer from this virus. Deeply unserious concept.

[crows-before-bros]

Oh right I forgot Breadsticks is a literal dinosaur.

Today I went to see Breadsticks and couldn't find them. As I started walking around I then heard the noise they usually make that could represent "hello, I'm friendly, etc" I saw them within a few feet of me feasting upon a dead seagull I was told had been there for a day or two. Breadsticks is very comfortable around me so I was able to get really close to get some shots.

However I was reminded that crows are carrion feeders. If you feed them out of your hand you are at risk of getting a potential disease/virus. Anything they eat could potentially have a trace amount left on you, and you could end up ingesting it and becoming infected. We did make contact not longer after this photo but through a layer of clothing (they will land on my arm now.) After realizing the whole situation I washed my hands and arms, then again when I got home. I hopefully will be fine but who knows if any trace amounts of that dead gull ended up on me.

If you are fortunate enough as I have been to gain a crowbro's trust and feed them out of your hand, remember that you are risking catching a disease/virus. Plus today I learned that crows could be potential carriers of a prions disease that deer carry (which has yet to make the jump to humans.) So best to wear a glove that you can easily take off and disinfect later.

[shadowsageingempress]

Akira Himekawa out here doing us all a favor.

The separation anxiety headcanon comes up pretty late in NoS, during the Zant battle. Basically as he’s teleporting Twi to various locations, he’s put Midna in a pocket dimension by herself and mocks her for falling in love with a human.

I also think Twi would also get scared/nervous whenever he’s apart from Midna.

Delivering the pages and context you asked for 🫡 can't send all of them because the images cap is silly, but this should cover most of it

Oh damn, this is so cool.

The way she goes absolutely feral when using the Fused Shadows is really cool, and goes to show how powerful her ancestor was. I like the idea that the longer she’s under their influence/in that form, the more she loses control of herself.

Once she’s back to normal, her apologizing to Twi for attacking him is also rather bittersweet, and shows that she does care about him.

And the way Twi not only forgives her immediately but defends her against his former allies just furthers this bond of trust and love.

Perfect.

[chaifootsteps]

Oh I also have an interesting idea for Alastor. It might sound ‘uncomfortable’ for some fans, but I find it to be a fascinating idea.

So there’s a thing that’s called ‘Chronic Wasting Disease’, and it effects deer, elk, and moose. It comes from the protein prion, and it’s very common in foods that deer/elk/moose eat. It effects the animals brains, such as drooling, stumbling, lack of coordination/energy, ears/head falling and drooping, frequently thirst, incredibly skinny(wasting), and shaggy fur.

Soo since Alastor’s a deer demon, I thought, why not make a mutated sort of disease in hell that can affect deer/elk/moose sinners??

It would be a cool twist to see the high and mighty Alastor becoming sick with a virus that infects demons like him, and is incurable

That would be pants-shittingly terrifying. Prison diseases are the stuff of nightmares.

[darkmaga-returns]

Everyone has heard the vaccine propaganda at least a hundred times because the vaccine industrial complex coined the term “herd theory,” and they shove it down everyone’s throats every time they come out with a new vaccine. There’s a massive logic breakdown though, with the “herd theory” concept and vaccine “efficacy” in general.

The entire purpose of getting a vaccine is to create immunity to a specific virus or infectious disease, but then, all the doctors and “disease experts” remind everyone over and over that the only way they work is if at least 80 or 90 percent of the population gets them. Come again?

Now imagine if we were all told that about vitamin C, that it’s completely useless if 9 out of 10 Americans don’t take any. Who would even believe that vitamin C helps boost immunity and protect against viruses? Who would bother?

For the rollout of Covid “vaccines” Fauci and his CDC goons told everyone we could “flatten the curve” of the pandemic if most Americans got injected

The vaccine lies are so bad, but still 270 million Americans rushed to the doctors, pharmacies and clinics to get their mass-sheeple injections because they fell for the fear-based scamdemic of the century. We all found out later that Covid barely kills anyone, especially healthy folks, young folks or babies.

We found out later that the Covid jabs don’t prevent infection, they just keep you from getting a “bad case” of Covid. But that was also a lie. We found out later that the vaccines don’t keep you from spreading Covid to others, but actually help you spread it through “shedding” the spike proteins.

In other words, no matter how many people got the shots, it didn’t matter at all. Even if every single American, including kids, babies and pregnant women, got the mRNA gene mutation stabs, it would NOT have helped stop the spread or infection of the Wuhan virus.

That’s why they had to create the fraudulent PCR tests, that signified anyone with any kind of bacterial or viral infection was “positive” for Covid-19. Sure. It was just another ploy to get everyone scared enough to go get injected with the deadly spike-prion-factory, self-assembling nanoparticle clot shots.