#Photothermal
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Research team develops anti-icing film that only requires sunlight
A KAIST research team has developed an anti-icing and de-icing film coating technology that can apply the photothermal effect of gold nanoparticles to industrial sites without the need for heating wires, periodic spray or oil coating of anti-freeze substances, and substrate design alterations. The group led by Professor Hyoungsoo Kim from the Department of Mechanical Engineering (Fluid & Interface Laboratory) and Professor Dong Ki Yoon from the Department of Chemistry (Soft Material Assembly Group) revealed that they have developed an original technique that can uniformly pattern gold nanorod (GNR) particles in quadrants through simple evaporation and have used this to develop an anti-icing and de-icing surface. The study is titled "Plasmonic Metasurfaces of Cellulose Nanocrystal Matrices with Quadrants of Aligned Gold Nanorods for Photothermal Anti-Icing" and is published in the journal Nature Communications.
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destielmemenews · 3 months ago
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"The researchers have not tested the process on humans, and it’s not clear what dosage of dye or delivery method would be necessary. Human skin is about 10 times thicker than that of a mouse, according to the researchers.
“Looking forward, this technology could make veins more visible, easing … the procedure of drawing blood or administering fluids via a needle — especially for elderly patients with veins that are difficult to locate,” said senior author Guosong Hong, a Stanford assistant professor of materials science, via email.
“Moreover, this innovation could assist in the early detection of skin cancer, improve light penetration for deep tissue treatments like photodynamic and photothermal therapies, and make laser-based tattoo removal more straightforward.”"
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savage-rhi · 11 months ago
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You can literally give cancer cells a "vibe check" and kill them.
What a time to be alive!
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edy-ulman · 9 months ago
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// It's translated as “photothermal radiation” rather than “emission”.
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litonlaser · 1 month ago
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How to use Q-switched ND YAG laser to treat café au lait spots?
 Guide to Q-switched ND YAG laser treatment of Café au lait spots, 1064 nm laser large light spot and low energy density effectively remove pigment spots.
Article source: https://www.litonlaser.com/how-to-use-q-switched-nd-yag-laser-to-treat-cafe-au-lait-spots/
Café au lait spots are a common hyperpigmentation disease. They are very common in clinical practice and can occur at birth or after birth. Many patients are deeply troubled by the impact of café au lait spots on their appearance.
Clinical café au lait spots are mainly treated with Q-switched lasers. Since the melanocytes of café au lait spots are distributed in the epidermis, epidermal melanocytes can be destroyed by using shorter wavelengths and smaller energy densities. For example, Q-switched 532nm Nd∶YAG lasers, 755nm alexandrite lasers, 510nm pulsed dye lasers, Q-switched ruby ​​lasers (694nm) and CO₂ lasers are all good choices.
Some clinical scholars have found that the use of Q-switched 1064 nm Nd:YAG laser laser to treat café au lait spots is very effective, and the possibility of pigmentation and depigmentation is low.
However, during the treatment process, the control of parameters such as energy density, spot size and endpoint reaction will affect the final efficacy. During treatment, it should be noted that the energy density should not be too large. A spot test can be performed first until the surface of the lesion turns white. So, how to choose the treatment spot size? Some clinicians choose a smaller spot, while others choose a larger spot. Which one is more appropriate? How to look at the endpoint response? Let’s learn about it together.
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1. What are cafe au lait spots?
It is a common pigmentary abnormality that usually appears before the age of 20. About 13.8% of the total population suffers from cafe au lait spots.
Cafe au lait spots appear and form at birth or in childhood, and increase in proportion with the growth and development of the body. Their morphology generally does not change. The clinical manifestations are light brown patches, similar in color to coffee with milk, ranging from light brown to dark brown, but each patch is the same color and very uniform, and the depth is not affected by sunlight. Cafe au lait spots range in size from a few millimeters to tens of centimeters, and are round, oval or irregular in shape, with clear boundaries and completely normal surface skin texture.
Cafe au lait spots can appear anywhere on the body, but the most common sites are the trunk and limbs. With age, some lesions will gradually deepen in color and will not disappear on their own.
Coffee spots are mainly caused by abnormally active melanocytes in the basal layer of the skin and abnormal increase in melanin. The formation of coffee spots is related to the following factors:
Environmental pollution: pollutants enter the human body through breathing, eating, etc., interfering with the normal development of the fetal skin.
High stress during pregnancy: If pregnant women are under great pressure, it may cause coffee spots.
Hormone level: The onset of coffee spots is also related to the hormone level of pregnant women, traumatic stimulation, etc.
Genetic factors: Coffee spots are hereditary and may be inherited.
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2. The principle of Q-switched Nd YAG laser treatment of cafe au lait spots.
Selective photothermal decomposition is the mechanism of laser treatment of cafe au lait spots. Currently, Q-switched pulsed laser is the most popular choice for the treatment of cafe au lait spots.
The mechanism of Q-switched Nd∶YAG laser treatment of skin pigment is the selective photothermal effect of laser, that is, the high-energy laser emitted instantly acts on the pigment particles through the skin. After absorbing the high-energy laser, the pigment particles rapidly expand and break into small particles. In the subsequent inflammatory reaction, most of the pigment particles are phagocytosed by macrophages, and then absorbed and discharged from the body; a small number of pigment particles migrate to the outside of the body with the epidermis, while the surrounding normal skin tissue is not damaged, thus achieving the purpose of treatment and having little effect on the surrounding normal cells.
Q-switched laser has a reasonable wavelength and can only penetrate the epidermis or dermis, and will not break blood vessels and nerves, etc., that is, Q-switched laser only acts on melanin and will not affect hemoglobin, blood vessels, and fat. Therefore, there is no possibility of misoperation of Q-switched laser, and it causes less damage to normal skin. Even if it hits normal skin, it will not damage it.
3. When using laser to treat cafe au lait spots, should a large or small light spot be used?
Small light spots are usually used for treatment in clinic, but some clinicians do have better results with large spots. Some experts in clinical literature mentioned that large light spots can improve efficacy and reduce complications. The more concentrated the energy irradiated under the skin, the less scattering there will be, and the melanin stimulation to the redundant surrounding tissues will be less, which can also reduce the occurrence of pigmentation and adverse reactions. Therefore, if the energy of a single hit is not enough, and the stimulation and impact on melanin are smaller, it is necessary to treat it multiple times.
Under normal circumstances, Café au lait spots will have a good effect after 2 treatments, while the treatment with a large spot mode may require 10 or 20 superimposed treatments to achieve the effect of 2 small spot treatments.
However, some studies have found that large spots can significantly improve efficacy and reduce complications. Choosing large spots with high energy can not only remove melanocytes in the epidermis, but also remove melanocytes in hair follicles, reducing the recurrence rate. This is a question of pros and cons. The most suitable parameters can be selected according to the clinical skin lesions and the condition of the patient’s skin.
Clinical research literature on large spots for the treatment of Café au lait spots. Some people use Q-switched 1064nmNd:YAG laser to treat Café au lait spots, and have achieved good results, with an effective rate of 76.1%. During the treatment, long pulses, large spots, and high frequencies are used to scan the lesions multiple times. This is significantly different from the common methods of laser treatment of Café au lait spots reported in existing domestic and foreign literature, namely, medium and short laser wavelengths (532nm, 755nm), small spots (3~4mm), low frequencies (1~2Hz), and scabs after treatment. The treatment effect is good but the adverse reactions are few.
In addition, Litonlaser and other studies have found that large spots can significantly improve the efficacy and reduce complications. The selection of large spots and high energy can not only remove melanocytes in the epidermis, but also remove melanocytes in the hair follicles, reducing the recurrence rate.
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4. What is the endpoint reaction of laser treatment for café au lait spots?
The endpoint reaction of treatment is determined by many aspects. Before laser treatment of Café au lait spots, the characteristics of the patient’s skin lesions should be comprehensively considered, and the energy, energy density, frequency and spot should be adjusted to effectively control the endpoint reaction to achieve the best effect.
The endpoint reaction of treating Café au lait spots is determined by the skin color of the patient, the color of the lesions, and the selected energy and wavelength.
For example, if the 532nm or 694nm Q-switched laser is used clinically, the immediate reaction is a frosty white reaction, or a slightly yellow frosty white reaction; the endpoint of Q-switched 755nm treatment is grayish white for the lesions; and picosecond laser treatment must not immediately produce a frosty white reaction, but a slightly frosty white or slightly frosty white reaction.
For comparison, the darker the skin lesions, the lower the energy. If the energy is not lowered at this moment, the skin lesions will definitely react particularly white, and the energy may be relatively high at this time.
Some clinical researchers use Q-switched 532nm treatment heads and Q-switched 1064nm treatment heads for alternating treatment. That is, the first treatment uses a Q-switch 532nm treatment head, and the treatment parameters are: frequency 10Hz, energy 3J/cm² to 10J/cm², pulse time 100ns, and spot diameter 2mm.
The handle is perpendicular to the skin, and the degree of irradiation is when the skin lesions turn grayish white and purpura appears under the skin. The second treatment after an interval of 2 months uses a Q-switch 1064nm treatment head, and the treatment parameters are: frequency 10Hz, energy 3J/cm² to 10J/cm², pulse time 100ns, and spot diameter 2mm.
The probe is perpendicular to the skin, and it is appropriate to have spot bleeding on the skin a few seconds after irradiation. The treatment parameters are adjusted at any time according to the changes in the skin at each visit, and the results show that the effective rate is 80%.
5. Why is 1064 nm laser more effective in treating café au lait spots?
At present, Q-switched 532nmNd∶YAG laser and 755nm alexandrite laser are commonly used for treatment in clinic. During treatment, the laser blade is vertically aligned with the skin lesion for scanning. After irradiation, the skin lesion turns white instantly. After surgery, redness, swelling, pain and scabs may occur. Adverse reactions such as bleeding, small blisters and blood blisters may occur. Pigmentation is easy to appear after the scab falls off. Some lesions are cured after 1~2 times, but quite a few lesions are not effective.
Some clinical scholars use Q-switched 1064nm Nd∶YAG laser to treat Café au lait spots with irregular shapes and light brown to dark brown lesions. The pulse width is 5~20ns, the spot diameter is 6mm, the pulse frequency is 10Hz, and the energy density is 2.4~3.3J/cm². The laser handle is vertically irradiated on the surface of the skin in front of the patient’s ear, and the skin is quickly scanned 1~2 times, with the degree of skin flushing. Treatment is once every 7~10 days, and a total of 6~15 times. A good therapeutic effect was achieved, with an effective rate of 76.1%. During the treatment, long pulses, large spots, and high frequencies were used to scan the lesions multiple times. This is significantly different from the common methods of laser treatment of coffee spots reported in a large number of existing literature, namely, medium and short laser wavelengths (532nm, 755nm), small spots (3~4mm), low frequencies (1~2Hz), and scabs after treatment. The treatment effect is good but there are few adverse reactions.
In addition, in 2015, a scholar reported a randomized single-blind controlled study of the efficacy of Q-switched 1064nm laser and Q-switched 532nm laser for 36 cases of Café au lait spots.
The results showed that the skin lesion clearance rate of 6 cases in the Q-switched 1064nm laser group reached more than 50%, while that of the Q-switched 532nm group was only 4 cases; the incidence of pigmentation in the 1064nm group was 0, while that in the 532nm group was as high as 50%; the recurrence rates were 17% and 33%, respectively.
At the same time, Li Qingfeng’s team from the Ninth People’s Hospital affiliated to Shanghai Jiao Tong University School of Medicine published an article in the European Journal of Medical Research titled Laser treatment for Café-au-lait Macules: a systematic review and meta-analysis, which conducted a meta-analysis of studies related to laser treatment of coffee spots and evaluated the effectiveness and side effects of various types of laser treatments for coffee spots.
The article found that for common Café au lait spots, QS-1064-nm Nd:YAG laser treatment has the best effect, and the possibility of pigmentation and depigmentation is low.
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6. Answers to common questions about cafe au lait spots.
Q: Why do cafe au lait spots appear? A: The pathological manifestations of cafe au lait spots are very similar to those of freckles, showing an increase in melanin granules in melanocytes and keratinocytes in the basal layer of the epidermis, but without the proliferation of melanocytes. The cause of cafe au lait spots is still unclear, and there is no evidence that cafe au lait spots will be inherited by the next generation.
Q: In what cases should we be alert to cafe au lait spots? A: Multiple cafe au lait spots indicate the possibility of hereditary diseases. For example, if there are more than 6 spots, we should be alert to the possibility of neurofibromatosis type I. Neurofibromatosis is an autosomal dominant genetic disease with an incidence of about 1/3000. To diagnose neurofibroma, first of all, the number of cafe au lait spots should be relatively large, at least 6 or more. The size of the spots should be greater than 5 mm in diameter before puberty and greater than 15 mm after puberty. In addition, cafe au lait spots can also be seen in tuberous sclerosis and other neuroectodermal syndromes, such as Albright syndrome, Watson syndrome and Russell-Silver syndrome. If you have a lot of cafe au lait spots on your body, it is recommended to go to the hospital for some necessary systemic examinations.
Q: What should I do if cafe au lait spots are not effective? A: Cafe au lait spots are difficult to predict due to the active metabolism of local melanocytes. Various laser treatments have different characteristics (parameters, times, intervals, etc.), and treatment plans need to be selected individually. Therefore, it is recommended to choose a small area of ​​lesions for spot testing during the first treatment to observe whether the laser is effective. For patients with larger lesions, a variety of lasers can be used for comparative treatment in the laser beauty department, and the best laser instrument can be selected for follow-up treatment according to the efficacy. On the one hand, the number of treatments and treatment costs can be reduced, and on the other hand, a lot of clinical empirical prediction results can be obtained, and a higher clearance rate is being obtained than previous treatments. At present, some cafe au lait spots are still difficult to remove or prone to repeated recurrence. If the laser treatment effect is not good and the plaque area is small, cosmetic surgery can be finally selected for removal. For those with larger areas, low-energy and high-frequency non-invasive laser treatment methods can also be selected. This method can more effectively inhibit melanin synthesis, thereby achieving a further clinical clearance rate.
Q: What is the best laser treatment for cafe au lait spots? A: Using a 1064 nm wavelength Q-switched YAG laser can effectively and safely improve and reduce cafe au lait spots. However, the specific treatment needs to be considered based on the skin’s tolerance. A large spot with low energy density is a robust treatment for removing pigment spots.
7. Summary of laser treatment of café au lait spots.
Café au lait spots are a type of pigmented hyperplastic disease caused by abnormal signal transduction pathways, which are often complicated by hereditary multisystem diseases. Their molecular genetic mechanisms are of great significance for genetic counseling, early diagnosis and treatment of many systemic diseases.
Q-switched 1064nm laser treatment of café au lait spots is more effective and has fewer side effects. The shape of the café au lait spots will affect the treatment effect. If the borders are irregular and the color is darker, the effect is better. If the color is light and the edges are regular, the effect is poor. In order to reduce the probability of postoperative pigmentation, multiple treatments are generally recommended to simultaneously improve the corresponding cure rate. At the same time, before laser treatment of café au lait spots, the characteristics of the patient’s skin lesions should be comprehensively considered, and the energy, energy density, frequency and light spot should be adjusted to effectively control the endpoint reaction to achieve the best effect.
If you want to know more about the treatment options for café au lait spots and their efficacy and safety, you can join Litonlaser’s photoelectric beauty core technology training course. The clinical instructor will share the treatment plan based on typical cases of various spots (freckles, coffee spots, chloasma, age spots, etc.), and explain the underlying logic of photoelectric treatment.
If you need to purchase Q-switched ND YAG lasers or other medical aesthetic equipment for the treatment of various pigment spots, please feel free to contact us: 20-year history of beauty equipment manufacturer.
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Researchers develop eco-friendly materials capable of purifying water
Professor Park Chi-Young's team successfully developed an atypical porous polymer material that can completely remove phenolic organic contaminants in water at ultra-high speeds. The porous material developed can efficiently remove not only microplastics in the water but also very small-sized volatile organic compounds (VOCs) based on photothermal effect. At the same time, it is expected to be utilized as a high-efficiency adsorption material that can be commercialized in the future as it has cost competitiveness based on raw materials and enables a solar-based water purification process.
Water pollution caused by the rapid development of the chemical industry is a pressing problem, and various water purification technologies and materials have been developed to address this issue. Carbon-based porous materials using existing adsorption mechanisms have limitations in that the adsorption rate is slow and high thermal energy is required for recycling. While various materials have been developed to improve contaminant removal efficiency, it has been difficult to develop materials that simultaneously satisfy excellent recyclability, high efficiency, economic efficiency of raw materials, and industrialization potential.
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nuber11223 · 2 months ago
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Gold PTT, also known as Gold Photothermal Therapy is an FDA-approved acne treatment solution which uses selective photothermolysis to effectively reduce sebum production, which is the root cause of acne.
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troskal · 4 months ago
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The Science Behind Gold Nanoparticles - What You Need To Know
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One requires an understanding of the exciting world of gold nanoparticles and their role in medicine and electronics. This blog post will, therefore, enable the exploration of various properties of these minute particles, methods of their synthesis, and areas of application that may have a direct impact on everyday life. You'll get insight into how gold nanoparticles are revolutionizing diagnostics, targeted drug delivery, and even monitoring of the environment. Join us in understanding the science behind gold nanoparticles and what you really need to know to appreciate their importance.
Definition and Characteristics
Appreciation of the concept of gold nanoparticles will only be the beginning after their definition is clearly understood. Gold nanoparticles, otherwise known as AuNPs, are simply small particles of gold with diameters that normally range between 1 and 100 nanometres. Due to their nanosize, they exhibit some very unique optical, electronic, and chemical properties compared to bulk gold that makes them suitable for use in many applications, including drug delivery, diagnostics, and sensing technologies.
One needs to realize the main features of gold nanoparticles to understand their huge potential. Their surface area-to-volume ratio increases astronomically with decreasing size, which means increasing reactivity. It is easy to functionalize these AuNPs, thus attaching a number of biomolecules and chemical agents to them, making them extremely versatile in several fields. They have another strong feature: very strong surface plasmon resonance, giving them absolutely unique optical features that make them a good candidate for application in biomedical imaging and photothermal therapy.
Synthesis Methods
Characteristics of gold nanoparticles are significantly influenced by the methods used in their synthesis. Various techniques exist, with the most prevalent being chemical reduction, laser ablation, and thermal decomposition. Each method favours different particle sizes and shapes, which can have significant effects on their properties. For instance, chemical reduction generally produces spherical nanoparticles, while laser ablation can yield a mixture of shapes, depending on the experimental conditions.
Methods of synthesising gold nanoparticles play a crucial role in their effectiveness for specific applications. The choice of stabilising agents and reaction conditions can greatly influence the size distribution, morphology, and surface chemistry of the particles. You might find that certain applications demand a specific morphology, such as rod-shaped nanoparticles for photothermal therapy, while others may require spherical shapes for targeted drug delivery systems.
Stability and Behaviour in Solutions
The two most important considerations for the practical application of gold nanoparticles are their stability and behavior in solutions. The stability of AuNPs depends on a lot of factors, such as particle size, shape, surface charge of the particles, or medium in which they are suspended. For example, an increase in surface charge on a nanoparticle will raise the electrostatic repulsion forces between them, avoiding aggregate formation and thus providing stability to the solution.
It is also known that the interaction of gold nanoparticles with other molecules in solution may alter their behavior. Those surrounding, as dictated by the environment, such as ionic strength and pH, will then control the behavior of gold nanoparticles. Understanding these interactions will help tailor the properties of AuNPs for a particular application, whether in improving efficacy in drug delivery using AuNPs or sensing capability.
Gold nanoparticles solutions should be treated with care and environmental conditions controlled in such a way as to ensure maintaining their stability. Aggregation is related to the loss of functionality; therefore, it definitely compromises its intended application. Optimizing methods of synthesis and factors that can interfere with or impact stability and behavior in solutions puts you better at placing gold nanoparticles in your research or practical application.
Applications of Gold Nanoparticles
Some of the most exciting and transformative applications of gold nanoparticles lie in the field of biomedicine, where their unique properties make them invaluable tools for various medical interventions. Their biocompatibility, tunable size, and surface chemistry allow for precise interactions with biological systems, making them ideal candidates for targeted therapies and diagnostics. In particular, you will find that gold nanoparticles are being employed in cancer treatment, imaging, and even as agents for photothermal therapy.
Biomedical Applications
On the forefront of biomedical innovation, gold nanoparticles play a crucial role in enhancing the efficacy of therapeutic solutions. They can be conjugated with targeting ligands, which allows you to aim treatments directly at diseased cells, reducing side effects and improving patient outcomes. This targeted approach has shown promising results in various cancer therapies, where gold nanoparticles serve as agents that can absorb light and convert it to heat, effectively destroying cancer cells while sparing healthy ones.
Drug Delivery Mechanisms
The versatility of gold nanoparticles extends to their application as carriers in drug delivery mechanisms. So, if drugs are encapsulated within or attached to the surface of gold nanoparticles, then you will see the enhancement in solubility and bioavailability for those drugs. It not only offers better ways of delivering a drug, but it opens avenues toward controlled release, meaning that the medication is administered over an extended time so maximal effect can occur.
Applications of this nature are especially useful for the treatment of chronic diseases, whereby constant levels of the drug in the blood are required. Gold nanoparticles can also be designed to facilitate colocated delivery of multiple therapeutic agents with combination therapy targeting various aspects of a disease all at once, something very important in a complex disease such as cancer.
Diagnostic Tools
Nanoparticles have brought a revolution in medicine, particularly in the methods of diagnosis, by increasing sensitivity and specificity in the detection of diseases. Due to their unique optical properties, particularly surface plasmon resonance, gold nanoparticles may be used to create extremely sensitive assays for the detection of biomolecules. This is very important during the process of early diagnosis, when timely intervention may drastically impact patient outcomes.
The gold nanoparticles will further enhance the development of lateral flow assays that are user-friendly, simple, quick, and can be used to produce results in both laboratory and point-of-care settings. Such innovative diagnostic tools not only increase efficiency but also ensure you get timely and accurate information on health conditions.
For instance, gold nanoparticles have already found applications in the development of rapid-testing kits for infectious diseases, including COVID-19. Applications like this underline their potential to realize prompt diagnosis and therefore inform treatment decisions, showing how gold nanoparticles could become an invaluable asset in modern healthcare.
Advantages and Limitations
Benefits of Using Gold Nanoparticles
For those exploring the field of nanotechnology, gold nanoparticles offer a multitude of advantages. Their unique optical and electronic properties make them valuable in various applications, such as targeted drug delivery, photothermal therapy, and imaging. You will find that their biocompatibility allows them to be safely introduced into biological systems without eliciting significant immune responses, paving the way for innovative medical treatments and diagnostics that could significantly enhance patient outcomes.
On top of this, gold nanoparticles can be easily modified to enhance their functionality. This allows for the precise tailoring of their surface properties to optimise interactions with specific biological targets, resulting in improved efficacy in therapeutic applications. The versatility of gold nanoparticles truly positions them as a pivotal tool in advancing nanomedicine, providing you with promising avenues for research and development.
Potential Risks and Toxicity
The use of gold nanoparticles is not devoid of challenges, especially where risks and toxicity are concerned. While they generally exert good biocompatibility, the effect of the accumulation of gold nanoparticles in the body, especially on long-term exposure, is an area of very important study. You have to consider that the size, shape, and surface chemistry of such particles may impact their interaction with biology, thereby going on to create cell responses or even toxicity in some cases.
It is worth noting, however, that gold nanoparticles in vivo behave differently from studies in vitro. There is a fear that the smaller nanoparticles, while able to penetrate cells with much greater ease, would bring about cytotoxic effects through inflammation or oxidative stress. These risks are things one ought to know as a researcher for the development of safer applications and to make proper assessments of the biological implications in using gold nanoparticles within one's work.
Regulatory Considerations
Probably that most important aspect related to using gold nanoparticles in any application is the regulatory framework that lords over the use of gold nanoparticles. Actually, most regulatory agencies are infringed on nanomaterials, and approval may be tight. With a view to compliance, which is very central in successfully bringing your projects from the lab into practical applications, you will need to understand these regulations.
For example, in the European Union, the legislation on nano-materials is very firmly put within the framework of the chemical safety legislation andMake use of broad data requirements in terms of their safety profiles before they are allowed to enter the market. This enunciates the need for proper risk assessments and establishment or development of standardized test protocols aligned to guiding principles from certain regulatory frameworks that will ensure the safety and effectiveness of gold nanoparticles used in your applications.
Summing up
In a nutshell, you need to know the science of gold nanoparticles if you are interested in their applications in the life sciences, electronics, and environmental science. The extraordinary optical, electronic, and catalytic characteristics of the nanoparticles provide a versatile platform for innovations from targeted drug delivery to advanced imaging techniques. It's therefore important that you understand how their size and shape affect the way they behave, so that you can make use of their specific properties in a variety of applications.
Furthermore, note that investigations on the optimization of methods for the production and stability of gold nanoparticles are constantly ongoing to ensure their safe and effective application in real life. Keeping up to date with these developments will allow you to be better placed to appreciate the potentials of such nanomaterials with respect to future technological development. The more one learns about this exciting field, the more potential opportunities one can find to incorporate gold nanoparticles into one's work or studies, thus contributing further to this developing field of nanotechnology.
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victoriaanisa · 4 months ago
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Discover how groundbreaking advancements are transforming the fight against climate change! In this video, we explore the innovative CuTCPP/MXene/TiO2 photothermal catalyst that efficiently converts atmospheric CO2 into valuable fuels like CO and CH4.
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heatcharger · 6 months ago
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Photothermal conversion-enhanced thermoelectric generators combined with supercapacitors: An efficacious ... - ScienceDirect.com
http://dlvr.it/T7MbSM
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y2fear · 8 months ago
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Polydopamine-Encapsulated Zinc Peroxide Nanoparticles to Target Metabolism-Redox Circuit Against Tumor Adaptability for Mild Photothermal Therapy
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alivewellnessclinics · 9 months ago
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Laser hair reduction is an aesthetic treatment that uses a concentrated beam of light to get rid of hair in different areas of the body. Laser hair reduction works through the process of photothermal reaction where the hair follicle is damaged while leaving the skin unaffected.
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litonlaser · 1 month ago
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Professional FDA Diode Laser Freezing Point Permanent Hair Removal Machine
 FDA diode laser freezing point hair removal machine, multiple wavelength options, high power output, painless permanent hair removal, safe and comfortable.
Article source: https://www.litonlaser.com/professional-fda-diode-laser-freezing-point-permanent-hair-removal-machine/
Although autumn and winter are the best seasons for laser hair removal, many people choose laser hair removal before summer arrives, and it has become a popular beauty project.
Below, Litonlaser has sorted out the medical and aesthetic knowledge of laser hair removal to review and review the technology of laser hair removal, a hot beauty project!
Freezing point hair removal is currently the most advanced permanent laser hair removal method. Based on the principle of selective photothermal action, it uses freezing point diode laser hair removal equipment. The laser penetrates the surface of the skin to keep the hair follicles at a certain temperature, gently inactivates the hair follicles and surrounding stem cells, and achieves the purpose of permanent hair removal. It can remove excess hair on a large area without pain and coolness, effectively protect the surrounding skin, and achieve the purpose of rapid hair removal.
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1. Principles of Ice-Point Diode Laser Hair Removal.
1.1 Principle of Laser Hair Removal.
Similar to the treatment of pigment spots and blood vessels, laser hair removal is also based on the principle of selective photothermal action. When the laser penetrates deep into the dermis, the melanin in the hair follicles and hair shafts will selectively absorb the laser, thereby generating heat.
However, unlike the treatment of pigment spots and blood vessels, the pulse width of the laser used for hair removal is wider than the thermal relaxation time of melanin, because our target tissue is not melanin. Current research believes that the vascular nerves in the hair papilla during the growth period, the hair matrix cells with strong differentiation ability in the hair bulb (called matrix above the hair papilla), and the hair follicle stem cells in the bulge of the hair follicle are the three important target tissues for permanent hair removal. The thermal relaxation time of the hair follicle is 40-100ms. The heat energy diffused from the melanin is transmitted from the hair shaft to the stem cells of the outer sheath of the hair bulb, destroying the germinal layer of the hair follicle, thereby achieving the purpose of accurately destroying the hair follicle structure.
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Ice-point laser hair removal uses the gold standard 808/810 nm semiconductor laser for laser hair removal. Through a specially designed dual-pulse laser, it irradiates the skin with only a low energy density. The first laser pulse through the epidermis heats the skin tissue and hair follicles. The second pulse selectively raises the temperature of the hair follicles to about 45 degrees. The sliding 10Hz laser ensures that the hair follicles maintain this temperature for a period of time, and the hair follicles and growth stem cells lose their growth activity, thus achieving permanent hair removal.
The biggest difference between ice-point hair removal and traditional laser hair removal in mechanism is that traditional laser hair removal requires instantaneous high energy to burn the hair follicles, while ice-point hair removal gently inactivates the hair follicles automatically, so it can achieve the purpose of permanent hair removal without over-stimulating the skin to avoid pain or risks.
2. Energy setting and operation points of diode laser hair removal.
Diode laser is one of the most commonly used hair removal devices, with a wavelength of 800-810nm. The most famous “moonlight hair removal” and “freezing point hair removal” are semiconductor lasers. The 810nm band is traditionally deeper, and the melanin absorption is moderate, which is more friendly to people with dark skin.
The commonly used “freezing point hair removal” is mostly sliding. Due to the heat conduction of cold gel and the cooling of sapphire in the handle, customers usually feel better.
In terms of parameter setting, there will be east mode and professional mode, which can be selected according to needs. Usually the energy density is 10-13J/cm². Single-site operation should not be done according to the operation interface. It can be operated for about 30-40s, otherwise the risk of burns is relatively high. The diode hair removal machine is suitable for hair removal of large parts such as chest, back, limbs, etc., and it is more comfortable.
Operation skills: The treatment handle is held vertically and close to the skin and a certain amount of force is applied. Diode hair removal is generally used for large areas. The local area (upper arm/calf/thigh) can be divided into three areas. During treatment, the gel needs to be added and replaced to dissipate heat. During treatment, slide quickly without pausing, and slide faster in areas with thinner skin.
3. Three major advantages of freezing point hair removal.
3.1 Really painless.
No need to burn hair with high energy instantly, only warm feeling, no pain, with full white sapphire/sapphire cooling, hair removal is as comfortable as warm stone massage.
3.2 Really fast.
Adopting professional In-motion sliding technology, bid farewell to traditional dotting operation, with a repetition frequency of up to 10Hz, the hair removal speed is increased by 5 times.
3.3 Really safe.
Adopting 10J low energy density, 20ms long pulse width, and full cooling system, the probability of side effects is almost reduced to zero.
4. Precautions for freezing point hair removal.
Shave the hair in the treatment area;
Apply the glue on the skin;
Stick the light-guiding crystal to the skin surface for operation;
First make three test spots, and then observe the immediate reaction of the skin. The normal reaction is that the skin or the hair roots are slightly red, and sometimes there is a burnt smell;
When the energy density needs to be adjusted, the increase should not exceed 2J each time;
For people with darker and more sensitive skin, it is common for the skin to have a delayed reaction within 24-48 hours. The energy density should not be increased arbitrarily because the immediate reaction is not obvious;
Post-freezing point hair removal care: cold compress (not ice compress, not less than 4℃) for ten minutes to half an hour until the discomfort is relieved; try to avoid sun exposure; if there is no side effect on the skin, makeup can be applied.
5. Specific steps of diode laser freezing point hair removal.
Step 1: Skin preparation. The technical term is skin preparation, and in layman’s terms, it is called shaving, that is, use a disposable hair removal knife to shave all the hair on the surface of both arms so that the light waves can “pull out the hair roots” during hair removal. Before skin preparation, please keep the hair removal area clean to ensure the effect.
Step 2: Cold gel. Apply a gel with cooling and refreshing effects to the hair removal area to maximize the protection of the skin and minimize the discomfort during the hair removal process. Make sure there is no hair on the inside of the arm, and you can also evenly apply an appropriate amount of gel. When hair removal, it will be “closely contacted” by the light waves to achieve the effect of tightening the skin.
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Step 3: Freezing point hair removal. Repeatedly contact the hair removal area with uniform force, allowing the light waves to thoroughly “encircle and suppress” the hair roots. As the intensity of the light increases, the skin will feel more and more intense. Different light waves are used, and the area of ​​hair removal and pain are different each time: the area of ​​freezing point hair removal is larger and there is no pain.
Step 4: Cleaning. Gently scrape off the gel and wash with clean water. After washing, quickly moisturize the skin and apply sunscreen. Do not use soap or other alkaline cleaning products to take a bath one week after hair removal.
6. Treatment of adverse reactions after diode laser hair removal.
6.1 Pain.
Pain during laser hair removal is a normal reaction. Thick hair shafts, dark skin color, and skin spots will cause additional pain. Current hair removal equipment has cooling devices to minimize pain. So we should try to remove the hair as cleanly as possible during pretreatment, leaving only the stubble at the root, and try to avoid spots and trauma. The gel can be applied a little thicker during diode hair removal, and avoid repeated sliding on the same part.
6.2 Erythema, edema around the hair follicles and other reactions.
This is a normal treatment reaction, and it can even be said to be the endpoint reaction of effective parameters. The degree and duration of erythema and edema are proportional to the treatment energy and treatment time, and are inevitably related to the customer’s skin color. Usually erythema and edema around the hair follicles can subside on their own after a period of time. We strengthen cooling during the operation, apply cold compresses immediately after surgery, and use topical glucocorticoid cream or ointment when necessary. At the same time, inform customers of possible erythema and follicular edema. Due to different customer requirements, many customers do not expect adverse reactions after hair removal. While communicating, we can appropriately reduce the energy and number of repetitions according to customer requirements.
6.3 Other serious complications.
Diode laser hair removal is generally very safe. Occasionally, there are serious complications such as burns and pigmentation, which require us to control the parameters and endpoint reactions of the machine. For hair removal, it is not a one-time project, and there is no need to blindly increase the energy. Occasionally, there are reports that patients induce hair growth after laser hair removal. Personally, I guess that it is similar to the principle of hair laser treatment. Too low energy promotes local blood flow and metabolism of hair, thereby promoting hair growth. In this case, you can try to increase the energy and the number of treatments.
7. FAQ about diode laser freezing point hair removal.
Q: What is the wavelength of diode laser freezing point hair removal? A: The wavelength of freezing point hair removal is 808 nm or 810 nm.
Q: Is freezing point hair removal permanent hair removal? A: Yes, after 3 to 5 freezing point hair removal treatments, the hair follicles will be damaged and new hair will not grow for a long time, tending to permanent hair removal.
Q: Is ice therapy hair removal safe? A: Very safe. Ice therapy hair removal is also called freezing point hair removal. It is a very safe laser hair removal method. Through the cold gel and the sapphire cooling system of the machine handle, the hair removal process can be made very safe and comfortable.
Q: Why do some people have more hair after laser hair removal? A: If you find that your hair grows more after laser hair removal, it is an adverse reaction to diode laser hair removal. In the study of the hair life cycle, we found that low energy can promote hair growth. So in this case, you can increase the energy appropriately and use high energy to destroy the hair follicles to achieve hair removal.
Q: In hair removal, is cold laser better or hot laser better? A: Laser hair removal is through the photothermal effect. The hot laser heats the hair at the hair follicle to inactivate the hair follicle cells, thereby achieving the purpose of hair removal, while the cold laser uses the treatment system on the machine, such as sapphire or white sapphire, to cool the surface of the human skin, and with cold gel, the customer’s epidermis feels cool and will not burn the skin. Therefore, the hot laser heats the skin follicles to remove hair, and the cold laser cools the surface of the human skin to ensure safety and suitability.
8. Choice of diode laser hair removal machine.
In the hair removal market, laser hair removal occupies most of the market, and diode laser hair removal is the most mainstream hair removal beauty project. Due to the climate and population in Europe, hair is more abundant, so hair removal projects are more popular. A good hair removal project needs to be matched with a good hair removal machine. For diode hair removal machines, Litonlaser, as a beauty machine manufacturer with 20 years of experience, has excellent diode laser machine production technology. We produce many high-quality diode laser machines through strict control of power, certificates, wavelength, laser bar, etc.
Our diode laser hair removal machines have FDA certificates, CE certificates and other certificates, and are certified by professional organizations to ensure the effect and quality of the machine.
In terms of wavelength, we provide single-wavelength lasers of 808 nm/810 nm, three-wavelength lasers of 755 + 808 + 1064 nm, and four-wavelength laser machines of 755 + 808 + 940 + 1064 nm.
In terms of machine power, the power of diode laser, we specifically refer to the power of laser bar. Litonlaser has multi-power diode laser machines such as 350W, 600W, 800W, 1200W, 2400W, etc. The appearance ranges from small portable machines to large vertical machines. You can choose according to the preferences of different customers and the needs of different markets.
If you need to know more about diode laser hair removal machines, you can contact us at any time: Medical beauty machine supplier.
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drforambhuta · 9 months ago
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Utilizing Nanoparticles for Diagnostic Imaging
Apart from targeted medication delivery, nanotechnology provides innovative solutions for diagnosing and imaging cancer. Nanoparticles can act as contrast agents for various imaging techniques like magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET), and fluorescence imaging. By attaching imaging probes, such as fluorescent dyes, quantum dots, or magnetic nanoparticles, to nanoparticles, researchers achieve high sensitivity and specificity in detecting cancerous growths. Additionally, nanoparticles' small size and surface properties enable their accumulation in tumors through the enhanced permeability and retention (EPR) effect, enhancing imaging technique sensitivity and facilitating early cancer detection for prompt intervention and better patient outcomes.
Exploring Therapeutic Nanomedicines Beyond conventional chemotherapy, nanotechnology has led to the development of innovative therapeutic methods for cancer treatment. Photothermal therapy, for instance, utilizes nanoparticles' photothermal properties to selectively eradicate cancer cells when exposed to near-infrared light. Materials like gold nanoparticles and carbon nanotubes can absorb light energy and convert it into heat, resulting in localized hyperthermia and tumor destruction while preserving neighboring healthy tissues. This approach offers a targeted and non-invasive way to treat solid tumors, with potential applications in surgery, radiotherapy, and combination therapies. Similarly, nanotechnology has propelled advancements in gene therapy for cancer treatment, where nucleic acid-based therapeutics are transported using nanoparticle carriers to regulate gene expression, hinder tumor growth, or bolster immune responses against cancer cells. Nanoparticles shield nucleic acids from degradation, aid in cellular uptake, and enable controlled release of therapeutic payloads, overcoming delivery challenges associated with genetic materials. Gene therapy holds potential for personalized cancer treatment by precisely targeting molecular pathways implicated in tumor progression and metastasis. Moreover, coupling genome editing technologies like CRISPR-Cas9 with nanotechnology opens avenues for accurately manipulating cancer-associated genes and rectifying genetic mutations contributing to tumorigenesis.
There are many good hospitals in Mumbai that offer health checkup packages including tests that are performed using nanotechnology for the early detection and management of cancer, such as a full body health checkup at Jaslok Hospital Mumbai.
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jlareditor1 · 10 months ago
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Breast cancer continues to pose a significant threat to women’s health around the globe, requiring continuous research and innovation in treatment. In recent years, metal nanoparticles have emerged as a promising means of treating breast cancer with greater precision and efficiency. The in vivo studies have indicated that metal nanoparticles, such as gold, silver, and platinum, have demonstrated a remarkable ability to selectively target breast cancer cells while sparing healthy tissue. These nanoparticles’ size, shape, and surface chemistry can be altered to enhance their biocompatibility, stability, and drug-loading capacity. They are also highly versatile for therapeutic applications due to their unique physicochemical properties, such as drug delivery, photothermal therapy, and imaging. This review focuses on recent in vivo studies evaluating metal nanoparticles’ safety and efficacy in treating breast cancer. Several studies have demonstrated that metal nanoparticles can trigger apoptosis, inhibit tumor growth, and reduce metastasis in cancer cells. Furthermore, using these nanoparticles with traditional chemotherapy and radiotherapy has demonstrated a synergistic effect, enhancing treatment efficacy. This review also examines the challenges and concerns associated with the clinical translation of metal nanoparticles. Factors like biocompatibility, pharmacokinetics, and long-term safety profiles are discussed in the context of regulatory approval and patient-specific considerations. In conclusion, this review highlights the evolving landscape of breast cancer treatment with the development of metal nanoparticles, as evidenced by recent in vivo studies. In addition to their therapeutic versatility, these nanoparticles can potentially improve patient outcomes and decrease the burden of breast cancer on society.
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Bio-friendly transparent temperature sensor technology that precisely measures temperature changes by light
Researchers have developed a transparent temperature sensor capable of precisely and quickly measuring temperature changes caused by light. This technology is expected to contribute to the advancement of various applied bio devices that rely on sensitive temperature changes.
The photothermal effect using plasmonic nanomaterials has recently been widely proposed in various bio-application fields, such as brain nerve stimulation, drug delivery, cancer treatment, and ultra-high-speed PCR due to its unique heating properties using light. However, measuring temperature changes by photothermal phenomena still relies on an indirect and slow measurement method using a thermal imaging camera, leading to the limitation that it is not suitable for local temperature measurement at the level of a single cell, which changes rapidly at the level of several milliseconds to tens of micrometers.
Due to the absence of precise information on temperature changes, photothermal effect technology has raised concerns about the understanding of biological changes and stable clinical application resulting from precise temperature changes, despite the spreading effect of its application.
Read more.
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