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deadsetobsessions · 7 months ago

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Danny always knew tax evasion ran in his veins. His parents hadn’t been the most… morally sound of people, and less so as ecto-scientists.

He just didn’t think their lessons would ever result in a criminal empire that spanned the entire city and then some. Danny hadn’t seen it coming. His parents definitely wouldn’t have.

“Good afternoon, Mr. Wayne. Mr. Fox.”

Danny ‘the Phantom’ Fenton sat down across from a rather tense looking (to Danny’s enhanced senses, anyways) Brucie Wayne and his right hand, Lucius Fox. He smiled pleasantly, matching Brucie’s vacant smile with that touch of Midwest suburban mother smile.

With his acquisition of multiple Gotham companies, his rather newly established Fentom Co. became one of the largest holding companies in Gotham, the first being Wayne Enterprises and the second being Drake Industries. After months of constantly working his butt off while fending off assassins, reforming Gotham’s slums and cleaning up some of the streets, and taking care of his nest of street kids, Danny garnered enough power to even stand close to Wayne Enterprises in terms of financial powers.

The topic of this meeting was, of course, the proposed merger of Wayne Enterprises’ Medical R&D division with Fentom Co.’s pharmaceutical department. Usually, Wayne Enterprises wouldn’t even consider such an offer, as their Medical R&D division was the most well funded and least likely to be part of a Rogue’s scheme- and therefore most beloved- department of the same nature in Gotham. However, Danny had something the other offers didn’t.

Blackmail.

His overly polite smile widened as Bruce’s mask twitched. His eyes slid over to Lucius Fox.

“It’s an honor to meet you, sir. I’ve heard much about your genius in… research and development.”

By that, Danny meant that he knew Lucius Fox helped develop Batman’s tech.

He did a lot of stalking that week. It felt rather… invasive, even if he did get a bunch of juicy secrets.

You know what they say: dead men tell no tales… but halfas are generally blabbermouths.

“Is that so? It is a pleasure to meet you as well, Mr. Fenton.” The man quickly glanced between the youngsters, accurately predicting that this might have something to do with Bruce’s active nightlife.

“Yes, it is such a pleasure to meet you.”

Wow, Danny didn’t think he’d ever heard anyone sound both so perky and dead inside at the same time, except for Susan at Gotham High’s bake sale.

Bruce wishes he could be a Susan. He’s at best a Becky.

“Will you be staying, Mr. Fox? You’re the head of the R&D department, correct?”

“Ah, yes-”

“Oh, Lucius! I think you had an appointment with the finance department right now! I heard Sally talk about it, you know!”

Lucius Fox sent an unreadable look at Bruce before rallying.

“Oh, it must have slipped my mind. My apologies, Mr. Fenton, it seems as though I can not skip this appointment.”

“That’s alright. I suppose it gives you… plausible deniability… should things go wrong, haha!” Danny allowed his smile to widen a little further than natural. Bruce tensed but Lucius Fox simply politely smiled and left the room.

Ignorance is bliss and all that, Danny amusedly thought.

As the door shut with a click, Bruce dropped the vacant Brucie smile and sighed.

“What do you want,” he gritted out. Danny wasn’t about to let that slide, not after he spent the better part of this month wrangling Bruce’s problem children.

“Ah, it must be because I’m from the Midwest, Brucie, but where I come from, we value these things called manners.”

You uneducated jerk, he doesn’t say.

Danny leaned back in his chair, loosening his smile into something relaxed and sharp.

“…” Oh, boy, Danny could just hear the other man’s blood pressure rising. “What is the purpose of your visit, Mr. Fenton?”

“Relax, Brucie,” Danny sing-songed in a non-relaxing way. “I’m just here to discuss a possible merger that I’m sure you’ll agree to, and give you a couple of updates on your… wayward bird.”

He heard Bruce take a slow, controlled breath. “Very well. Where. Would. You. Like. To. Start.”

Danny ignored the gritted out sentence. He passed a contract to Bruce, who took it like he was handling a live bomb.

“Here’s the proposal, Mr. Wayne. Please, look it over.”

He watched as Bruce looked over the contract with an eagle eye before lowering it, scrutinizing Danny.

“This is… very fair.”

Danny raised an eyebrow. Of course it was fair. Danny wasn’t interested in exploiting the Waynes, despite them being very able to afford it.

He’d brought fifty manufacturing sites for pharmaceuticals, and offered up a building where both companies could send their workers. He provided top notch security- that definitely didn’t have any talons on staff, what were they talking about?- that came from his own security division. Granted, most of them were reformed and trained goons, but hey, creating jobs can only help Gotham’s economy and help break the cycle of poverty, right? Guaranteed by the Wayne name and, most importantly, uncompromised medicine that was accessible to everyone would be a damn good start. He’d also have Penguin’s empire to distribute it to those who couldn’t make it to a clinic or a store, and there were plans in there to work with and establish contracts with Gotham’s welfare department. Well… once Danny finished replacing them with people who wouldn’t try to take a cut of the funds and actually cared about the people. He was thinking… the multitudes of poor grad students and parents that need income. He’s in the process of building childcare centers and…

It’s a good thing he managed to save money from the taxes (thank you, Gotham’s morally ambiguous tax experts that were in desperate need for clients! He could do it himself but having a team of accountants at the ready was seriously so helpful.) because ancients knows the government weren’t about to step into Gotham and help the people here. He needs so much money to pull all of this shit off and a lot of it has to be clean.

Danny inwardly sighed and marked another thing onto his to do list.

Make money laundering fronts.

“Of course, Mr. Wayne. You didn’t think I’d come in here demanding money, did you?”

“I considered it.”

“I am, in fact, trying to help Gotham. You might not agree with my methods, but I’d rather not damage Wayne Enterprises when it’s doing so much to help the people.”

Ugh, he was doing too much work. Danny just wanted to- hah- chill at home and read bed time stories to his kids.

Bruce Wayne, the specific blend between Brucie and Batman, regarded him silently. Danny felt like he went up a few notches in the respect ladder.

Nice.

“You’re a criminal.”

“Says the man in the bat-suit breaking into places and assaulting people.”

Bruce’s hands spasmed around the contract. Danny smiled at him, taking a sip of the coffee they’d prepared. Oo, nice!

“Ah, I heard you’re adopting- pardon, fostering- Tim Drake. Getting empty nest syndrome, Brucie?” He slipped back into using Bruce’s first name. The proposal was formal. This… was very much not.

“What about it?”

“That’s very kind of you. Speaking of which, well, of your birds, I was wondering if you remembered what I asked you to do.” Danny continued, not giving Bruce a chance to reply. “Didn’t I ask for you to keep your birds in line, Brucie?”

The CEO straightened even further, form filling out to be Batman’s imposing figure. “I did.”

“No, you didn’t. Do you know where your charge is, right now? No, not the formerly dead one,” Danny tilted his head, smile shrinking.

“Don’t you dare do anything to Tim. I swear, if you even lay a hand on a strand of his hair, I’ll-”

“Sit your Armani clad ass down, Bruce.” Danny snapped. “Your son’s in your office. I don’t harm children, and your assumptions are deeply insulting. Threaten me again, Bruce, and I’ll make sure you know exactly how much I know about your birds, your cousin, and the commissioner’s daughter.”

Bruce snarled but leashed his anger just enough to sit back down. He itched to go check on Tim, but leaving a threat like Phantom unwatched felt inherently wrong.

“Your other son,” Danny continued. “Is doing quite well. He’s learning that he has hobbies again. He’s actually working under me, you know.”

“He’s what.”

Oh, yeah, that tracks. It figured that Jason wouldn’t tell Bruce about anything. He’s still conflicted about his death. Danny got it.

“Ah, that’s precious information. You’ll have to offer something of equal value if you want to know. There is, on the other hand, a piece of information I’ll give you for free.”

Danny paused for the dramatic effect. It was lost on Bruce, the ultimate drama queen of this world.

“The League of Assassins are hanging around Hotham lately. It’s getting tedious, getting rid of them. I suggest talking to your old flame, you know, with words and what little communication skill you’ve got rattling around in your noggin to get them to pull back. Her interest is… unnaturally focused on Jason.”

Danny read the dark agreement swimming about Bruce’s face and inclined his head. “Should negotiations fail, rest assured that Jason will be protected.”

“…Thank you.”

“You are most welcome. Go ahead and discuss the contract with Mr. Fox, I am sure you’ll find little problems with it. Ah,” Danny stood up, fixing his suit jacket. “And you should probably check up on Timothy. He’s probably having a great time in your office, Mr. Wayne.”

“I’ll see you out.”

“Of course.”

Having Batman escorting him out should probably be more intimidating.

Danny stood in the elevator, waiting for Bruce’s contemplative silence to put itself into words.

Sure enough, “What… what kind of hobbies does Jason have now?”

“I’d tell you to ask him, but you two aren’t on speaking terms, are you? He likes books, of course, but recently, he’s found an interest in glass blowing. He made quite a bit of progress on his attempts at sun catchers.”

“I see.”

Well, Danny’s not about to step on that landmine any more than he has to.

——

“Danny.”

“Oh, hey, Jason. Sit down, we were about to have dinner.”

Jason clambered into the window. Danny sighed. He had a door, but by the way Jason never used it, it was like the door didn’t exist.

“Mind telling me why the old bastard showed up on my rooftops with a bunch of glass and glassblowing tools?”

Danny smiled. “No idea.”

“Uh huh.”

Danny placed a hand on his chest and put on his best woe-is-me expression. The teen’s face twitched in annoyance. “Doubt? At me? Why, I never!”

A bread roll thwacked him in the face.

#dpxdc #danny phantom #batman #bruce wayne #jason todd #tim drake #dc x dp #red hood #bamf danny phantom #crime lord Danny #accidental crime lord Danny

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tuttsanpharmaceutical · 1 year ago

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#pharmaceutical company #pharma company #pcd pharma company #pharma industry #pcd pharma industry #healthcare #pharma third party medicine manufacturing #Research and development #the pharmaceutical industry.#HowtoStartaPharmaceuticalCompany #tutsanpharma

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batboyblog · 3 months ago

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Things the Biden-Harris Administration Did This Week #31

August 9-16 2024

President Biden and Vice-President Harris announced together the successful conclusion of the first negotiations between Medicare and pharmaceutical companies over drug prices. For years Medicare was not allow to directly negotiate princes with drug companies leaving seniors to pay high prices. It has been a Democratic goal for many years to change this. President Biden noted he first introduced a bill to allow these negotiations as a Senator back in 1973. Thanks to Inflation Reduction Act, passed with no Republican support using Vice-President Harris' tie breaking vote, this long time Democratic goal is now a reality. Savings on these first ten drugs are between 38% and 79% and will collectively save seniors $1.8 billion dollars in out of pocket costs. This comes on top of the Biden-Harris Administration already having capped the price of insulin for Medicare's 3.5 million diabetics at $35 a month, as well as the Administration's plan to cap Medicare out of pocket drug costs at $2,000 a year starting January 2025.

President Biden and Vice President Harris have launched a wide ranging all of government effort to crack down on companies wasting customers time with excessive paperwork, hold times, and robots rather than real people. Some of the actions from the "Time is Money" effort include: The FTC and FCC putting forward rules that require companies to make canceling a subscription or service as easy as signing up for it. The Department of Transportation has required automatic refunds for canceled flights. The CFPB is working on rules to require companies to have to allow customers to speak to a real person with just one button click ending endless "doom loops" of recored messages. The CFPB is also working on rules around chatbots, particularly their use from banks. The FTC is working on rules to ban companies from posting fake reviews, suppressing honest negative reviews, or paying for positive reviews. HHS and the Department of Labor are taking steps to require insurance companies to allow health claims to be submitted online. All these actions come on top of the Biden Administration's efforts to get rid of junk fees.

President Biden and First Lady Jill Biden announced further funding as part of the President's Cancer Moonshot. The Cancer Moonshot was launched by then Vice-President Biden in 2016 in the aftermath of his son Beau Biden's death from brain cancer in late 2015. It was scrapped by Trump as political retaliation against the Obama-Biden Administration. Revived by President Biden in 2022 it has the goal of cutting the number of cancer deaths in half over the next 25 years, saving 4 million lives. Part of the Moonshot is Advanced Research Projects Agency for Health (ARPA-H), grants to help develop cutting edge technology to prevent, detect, and treat cancer. The President and First Lady announced $150 million in ARPA-H grants this week focused on more successful cancer surgeries. With grants to Tulane, Rice, Johns Hopkins, and Dartmouth, among others, they'll help fund imaging and microscope technology that will allow surgeons to more successfully determine if all cancer has been remove, as well as medical imaging focused on preventing damage to healthy tissues during surgeries.

Vice-President Harris announced a 4-year plan to lower housing costs. The Vice-President plans on offering $25,000 to first time home buyers in down-payment support. It's believed this will help support 1 million first time buyers a year. She also called for the building of 3 million more housing units, and a $40 billion innovation fund to spur innovative housing construction. This adds to President Biden's call for a $10,000 tax credit for first time buyers and calls by the President to punish landlords who raise the rent by over 5%.

President Biden Designates the site of the 1908 Springfield Race Riot a National Monument. The two day riot in Illinois capital took place just blocks away from Abraham Lincoln's Springfield home. In August 1908, 17 people die, including a black infant, and 2,000 black refugees were forced to flee the city. As a direct result of the riot, black community leaders and white allies met a few months later in New York and founded the NAACP. The new National Monument will seek to preserve the history and educate the public both on the horrible race riot as well as the foundation of the NAACP. This is the second time President Biden has used his authority to set up a National Monument protecting black history, after setting up the Emmett Till and Mamie Till-Mobley National Monument on Emmett Till's 82nd birthday July 25th 2023.

The Department of The Interior announced $775 million to help cap and clean up orphaned oil and gas wells. The money will help cap wells in 21 states. The Biden-Harris Administration has allocated $4.7 billion to plug orphaned wells, a billion of which has already been distributed. More than 8,200 such wells have been capped since the Bipartisan Infrastructure Law passed in 2022. Orphaned wells leak toxins into communities and are leaking the super greenhouse gas methane. Plugging them will not only improve the health of nearby communities but help fight climate change on a global level.

Vice-President Harris announced plans to ban price-gouging in the food and grocery industries. This would be a first ever federal ban on price gouging and Harris called for clear "rules of the road" on price rises in food, and strong penalties from the FTC for those who break them. This is in line with President Biden's launching of a federal Strike Force on Unfair and Illegal Pricing in March, and Democratic Senator Bob Casey's bill to ban "shrinkflation". In response to this pressure from Democrats on price gouging and after aggressive questions by Senator Casey and Senator Elizabeth Warren, the supermarket giant Kroger proposed dropping prices by a billion dollars

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the-midnight-blooms · 3 months ago

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ᴍᴇ ᴀɴᴅ ᴍʏ ʜᴜꜱʙᴀɴᴅ

pairing: CEO!park seonghwa x scientistwife!reader

AU: modern au

word count: 6.3k

masterlist

In the midst of a fragile soul dwindling under the aches of animosity, the married couple laid in bed with their backs facing each other. The husband, Park Seonghwa, an esteemed CEO of a pharmaceutical company ‘Park Pharmaceuticals.’ had the front board of the book lodged into the silk casing of his pillow with his other hand steadying it so he could still, quite painfully, scan his eyes over the text. Agitated, he got up with a grunt before sitting up to finish the chapter of his book. With his scientists publishing reports on the latest medicine they were developing, he immediately rushed back to his university textbooks to affirm he was still equipped with the necessary knowledge to understand the science. Meanwhile, Mrs Park- a research scientist at Park Pharmaceuticals' rival company, ‘Kim Pharma.’ was battling against her insomnia despite motherhood knocking her straight off her feet. Their daughter, Park Dami, was fast asleep in the room next door to Seonghwa’s study cuddling the little Toothless toy he had gifted her when she was still a cherub. It had seemed that Mrs Park was prone to falling asleep at the most odd times of day, whether it be during dinner or cleaning the home.

Perhaps it was the heartache she was suffering from. The love that she had held for her husband was a permanent fixture, a vow that she had promised not to break, and one she had not and never would for as long as she lived. However, the increasingly distant behaviour from her husband in light of his burgeoning role as CEO had her heart yearning for him. Being a mother was difficult and of course, so was Seonghwa’s job. Yet, he also had duties as husband and a father, which he seemed eager to abandon altogether.

“Why can’t you try to understand how difficult it is for me to do all of this? So much pressure at work, then I come to you going on about some stupid dinner with your parents!” He shouted, she flinched at the dissonance of his noxious tone reverberating off the walls of the small study- biting down at her lip.

“I’m sorry, I’ll leave.”

“Sorry, my arse. If you were sorry, you wouldn’t be fucking nagging in my ear all the time, would you?” He barked, as she sped out of the room. It had been three weeks since she had, politely and quietly, asked her husband if he was free to attend her mother’s dinner party. He refused, erratically, and despite having apologised with saccharine kisses and diligent promises, he didn’t turn up to dinner in the end.

“Oh he’s busy Mum. He’s seeing to some of the lab work, you know how stressful it was for me.” Her father complained light-heartedly, raising how unfair it was of him to neglect his family.

“Do you want to me have a chat with him? I can give him a good word.” Hastily, she steered her father away from that direction. The last thing she needed was Seonghwa to turn around and blame her for the earache her father would give.

With a relentless sigh, she sat up reaching for the bottle of water on the nightstand. His eyes flickered at her movements, lips moving up and down to form the shape of the words as he silently committed them to memory, forming judicious links between the knowledge and application.

“Seonghwa.” She called out for him, he hummed in return, barely reeling his eyes off the page. Please look at me. “I was thinking about going back to work again. I contacted my manager about restarting and at the moment I would only need to go in for about two days or so.” Shutting his book close, he finally met her stare, deep in contemplative thought.

“Do you think you can work and take care of Dami at the same time?” He questioned. She had thought about this several times before she dialled in her manager’s number. As much as she had inherited her father's kind-hearted nature, stunning beauty, and soft-spoken voice in the end it was the passivity she had drawn from her mother naturally rendering herself subservient to prioritise ones needs over her own. Essentially, if she had told Dami to keep her lips on a tight seal and remain of the sofa the whole day: she would.

“I’m sure I can as long as she's in sight. She'll be in nursery from September, so I'll be able to start work.” He fell a little quiet, turning to drop his book onto the night stand.

“Ok, if that’s what you want. If you need me to come home earlier, I mean I can’t at the moment, but in a few weeks time if you need me to-then I will.” Nodding, she sent him a grateful smile before sliding back under the covers to turn her night light off.

Her heels clicked, exasperatedly, on the porcelain white floor dashing straight through the double doors; her heart pounded furiously against her chest, a violent ache gnawing at her arteries. With her body almost barging into a number of figures, her anxious apologies echoed into the swamped corridors, in which her colleagues shook their tired heads in annoyance. Finally, reaching the top floor she scuttled out of the elevator catching the eyes of Mrs Lee.

"Lab coat, darling, lab coat." Squealing, she unbuttoned the off-white coat, scowling at the permanent pen marks and splashes of iodine before handing it to Mr Kim's assistant. Mrs Lee, threw the coat onto her seat, gesticulating for the young scientist to follow her. After a short knock, the heavy glass door was pushed open; several pairs of eyes darting their way.

"Ah, Miss Cheong! How nice of you to join us!" Hongjoong exclaimed, a teasing glint in his eyes that wanted to make her wipe the smirk of his lips.

"My apologies, Mr Kim, we ran into a problem down at the lab." She explained, a blush forging on her cheeks as a grave set of eyes burned into her skin.

"No worries. This is Miss Cheong, she will be our project lead on the next Kim-Park program." The Kim-Park program was founded by Kim Hongjoong of Kim Pharma and Park Seonghwa of Park Pharmaceuticals. With both companies leading the pharmaceutical industry, both founders decided in order to produce a greater economic boom, and serve an excellent supply chain of mandatory medicine; both of their greatest minds could work together to create poignant breakthroughs in the scientific sector. After all, the two companies had the countries top scientists working for them but together they could very well improve the nature of modern medicine. Hence, today both CEO’s came together for a kick off meeting establishing the blueprint for their next, biggest projects.

"'No worries?'" A derisive voice arose from across the room, where she snapped her head to find a man with wide eyes and thin-rimmed square glasses that sat at the bridge of his long nose, staring back at her. His long, slicked back hair that fell past his ears as he, mockingly, cocked his head to the side in amusement. "I didn't know Kim Pharma tolerated tardiness, Mr Kim." Returning his stare back to Hongjoong, he raised an eyebrow anticipating his answer.

“What was the problem down at the lab?”

“House fire." She retorted, "And I had to assign interns some lab work. Kim Pharma doesn't tolerate tardiness Mr Park but your project manager doesn't seem to be here? We'd have valued him being present at the kick off meeting." His face heated red in embarrassment as he gritted his teeth.

Park Seonghwa was insufferable.

The worst thing about him wasn't even that he was pedantic and scrutinised her work with a keen eye, or that his sharp attention-to-detail left her wanting to force him to chug a beaker of concentrated hydrochloric acid. It was that under his strictly co-ordinated demeanour, he was a beautiful man blessed with an angel's aura. It was that he was tall and that his voice could hypnotise her; send her lunging over a precipice into the expanse of uncharted oceans. At times his allure had her wanting to excuse her pathetic hatred. They bickered at every meeting, every email was sent with 'Regards' rather than 'Kind Regards'. It wasn't long before the bickering had transgressed to shouting in the boardroom as he began to question her teachings, snickering at every intellectual point she made as if she had not graduated from university with the same degree as himself.

"You forgot to add that cisplatin is a cis isomer." He stated, as she sat across from her in his office. This time, she didn't bother to retain herself from rolling her eyes. "A problem, Miss Cheong?"

"Who's reading this report, Mr Park? A high school student or the manufacturer? Any man with common sense and college level chemistry knows that cisplatin is a cis isomer. Do you want me to also write down that it has a square planar shape with a bond angle of 90 degrees?" She snapped, leaning back in her chair with a disgusted look. He smirked taking off his glasses, cleaning the lens with the hem of his blazer sleeve. Dear god. Sedate me.

"No, but you do need to explain how cisplatin works in detail. It only works as cis isomer, not trans. You didn't specify that."

"You're incredibly pedantic." Pushing his glasses up the bridge of his perfectly defined nose, the smirk remained fixed on his lips. "I'm not surprised people are handing in resignations, at your company, every week."

"They can leave if they wish, lazy people don't contribute to Park Pharmaceuticals' success." Oh and he was cocky too. As well as being a pretty face full of wits, Park Seonghwa was also wrought with egotism that made her want to wrangle his gorgeous, slender neck. "Have you ever considered joining our company?" A snicker escaped from her lips which eventually transcended into a laughter that wholly baffled him.

"I'm afraid I'd be a part of that sorry statist-,"

"I'm sorry for being an arsehole, Miss Cheong. Can I make it up to you?" And when she questioned him how he would make it up to her, he proposed the idea of a date. All he wanted was her, regardless of her much she was everything he was not. “Go on a date with me, please.” He blurted, with her feet rooted to the ground and lips falling into a thin line his heart palpitated within his chest. He sought the way her hair fell over her shoulders in light waves having ripped it from its knot after she walked out of the lab. Her pink lips were practically begging to be touched by his, he wanted to soothe the symphony of weary sighs that dispersed from her, and the headache that wracked her brain from his abstruse behaviour. Above all, he was falling in love with Miss Cheong because he despised her in such a paradoxical way. He hated the way she was smarter than him and beautiful in the way that she must have been carved from the clouds of heaven.

It often made her giggle at Hongjoong's astonishment when she handed him the wedding invitation. His excitement when he ripped open the seal to read Seonghwa's name as the groom, dropped the smile from his face as he looked at his college friend.

"You're marrying the enemy?" She shook her head at him, almost scolding him for deeming Seonghwa the 'enemy'. "This isn't what I meant when I said 'Fuck Park Seonghwa." Lobbing the pillow at his head, he dramatically sunk into his sofa as their childlike laughter eructed into the blithe atmosphere.

It had felt like a distant dream now, to be loved and adored in the ways that he once did. To be held as if every touch was their last, to be kissed as if their lips would never meet again and they were lovers in the midst of an age-old war that would tear their nimble hearts apart. To have her husband again and not a dispassionate demon who tore past the gates of hell and inflict all the condemned’s curses on her.

Giving you my all, giving you my everything. Laying my life down at your feet, stripping myself of my own honour just to feel something by you. A glance, a breath, a sigh. You tell me to leave- I don’t mean anything to you anymore.

"Hwa, you could have at least told me you weren't going to go in the first place. Then I wouldn't have gone to the company party." Sat at the foot of the bed, he pulled the jumper over his torso, pulling his trapped hair out from the neck hole. He bit his tongue as his wife rebuked him for his absence, once again. "Do you know how humiliating it was for me to be the only one sat without her husband there?"

"I told you I was going to run late."

"You were four hours late, and you're a half an hour drive to the office! Why didn't you say no, in the first place?" Tearing the earring out from her lobe, she sunk into the chair trying her hardest to not slip into tears; the sympathetic stares of hundreds etched into her memory. How stupid did she look for being dressed so ostentatiously, when the real jewel was not even in her possession? The clatter of pearls emptied into the drawers, hands buried into palm of her hands closing her eyes to relive the myriad of dejection. They never said marriage was this painful. Hard, yes. But not painful. "Hwa, do you love me?" She inquired, turning around in her seat.

"What?"

"It's as simple as you think. Do. You. Love. Me?" Her voice wavered as she asked him, the distant stare in his eyes revealed answers to the questions that she did not want answered.

“If I didn’t love you, I wouldn’t have married you. Or given you a beautiful daughter. I miss one, silly, company event and you start throwing a tantrum.”

“This isn’t the first time you’ve completely abandoned me!” Her shout restituted off the thin light blue walls, jumping from her seat at his petty arguments. “You are such a terrible husband and you make me feel trapped in this marriage!”

“And you fucking suffocate me! You suffocate me!” He roared across the room, his strident tone penetrating through her, grazing down the surface of her heart. Rupturing the weak seams that held it together. Stumbling backwards, her palms gripped onto the mahogany table; shaking, biting down her lip to prevent a sob from escaping. "The only time I felt like I could ever breathe, in this marriage, was when I was not with you. When I was at work, or with the others, or just anywhere else. But never with you." Dipping her head, away from him, she shut her eyes as tight as she could.

"Please stop." she whispered, a plead so quiet it almost went unspoken. Yet Seonghwa heard it anyway because no matter how angry he was, their souls were still intertwined. Their hearts beat as one, they were uniform, one whole being. Slowly, he treaded towards her, mimicking the dip of head.

"Why? Can't you take the truth?" he mocked. Full tears pooled in her eyes, her chest burning from holding in her breath. "I should divorce you." He proclaimed, without a stutter. That was enough to break her. An obnoxious wail infiltrated into the void of the room. Was that what he wanted? To provoke some sort of emotion from her to satisfy his ego? He scoffed, before darting from the room-slamming the door shut behind him. Wrought with tears she trudged to her bed, slipping under the covers; sobbing herself unconscious.

"Mummm. Ammiii. Ammaaa." A small voice whispered, the softness soothing the persisting ache in her chest. Holding back the smile ready to break through, she fixed her eyes shut waiting to see what her daughter would do next.

"Dami, let your mother sleep. Come on." The urge to smile had dropped instantaneously, the familiar sense of forlorn gushing into her again; his sweet, addictive voice puncturing holes into her heart.

"I'm hungry." She could hear the pout on her daughter's lips. Huffing, she groaned loudly snapping at her daughters attention, who jumped up and down in excitement of her mother awaking. Reaching out for her child, she picked her up settling her down on her laps. "Mama, I'm hungry." She squeaked.

"Have you washed up yet?" She shook her head. "Ok, let me go to the bathroom first. Then I'll help you."

"I'll help her wash up." Seonghwa offered. Refusing to look at him, she simply gave him a curt nod, the sight of his face wanting to make her erupt into a fit of sobs.

"I promise I'll never make you cry." He had promised, before their marriage. They sat under the stars, the cool wind brushing at their cheeks. Astronomy books sat scattered around her as she attempted to map out constellations in the beaming night.

"And if you do?" She challenged, playfully smirking. With a cute frown he gave her a nudge.

"I promise I won't but in the 0.00001 percent chance that I do, then you should leave me. You’re worth more than the moon to me, and to hurt you is the deadliest sin I can commit." He immediately leaned forward to swoop her into a deep kiss- both of them smiling as they did. The memory of his now-broken promise brought tears to her eyes again. Tightly pressing her palm to her mouth, to hold back her cries, she sucked in yet another breath. I can do this. I can do this. I can do this.

Gripping onto the bathroom sink until her knuckles bled white, her knees hit the floor. Nicking the handle of the tap- tears freely flowed down her cheeks as the water rushed through the basin at rapid speed. I want my baby back.

Feeling the heavy burden of a collapsing marriage, her shoulders sunk as she chopped at the onions, preparing their dinner. Dami sat on the stool by the kitchen island, with her mini crayons scribbling over the pictures in the colouring book.

“Mama, why did Appa sleep in my room yesterday?” Scraping the onions into the pan, she grabbed the wooden spoon to stir it.

“He was missing his little princess. He wasn’t causing you trouble, was he?” She teased, sending her a forced smile. God, it was becoming increasingly difficult to stay happy. To smile was to pain her cheeks, they felt more contented relaxed than to uplift and radiate an aura of joy that didn’t seem to exist within her anymore.

“He’s so big, I fell off bed.” She snorted, laughing at her child’s proclamation. It was not long before a thought occurred to her that whenever they slept in the same bed- it was always her that took up the most room-rather than him. A fond memory occurred to her, specifically a night where her body was plastered to his.

“Ah, jagi, can you move a little? I’m up against the window?” Her body shuffled slightly to the left, giving him room to breathe a little bit more. “Thank god.” He huffed out a sigh of relief, her lips fell into a pout- as she rolled further away from him towards the edge of the bed. If space was what he wanted, then she was going to give it to him. Seonghwa’s arm outstretched for her, the cold air battering his skin was no comfort, he wanted her again. A tantalising laugher infiltrated the air, he shuffled closer to her pressing his lips to the top of her head.

“Never mind I need my cuddly bunny.” He sang, nestling his face into the crook of her neck. Now, she couldn’t remember the last time he had held her so close to himself. If anything, he needed the space now and rested just less than a metre apart from her each night.

“It was nice! Appa is a teddy bear.”

“Am I, my princess?” Turning away from the doorway, she opened the cupboard to reach for the spices, shielding her melancholic face away from him. The sweet dissonance of giggling entered her ears, if he had no love to spare for her at least he had enough to spare for his daughter. “Ahem, I’m going on a business dinner tonight.”

“Ok.” Seonghwa watched her, resting his hand on the top of his daughter’s head who went straight back to colouring in the flowers in her book-switching to a pink crayon at that. “What time will you be home?” He shrugged, then quickly noticed that with her back to him she wouldn’t see.

“I don’t know. Don’t wait up.” How could he say that knowing that there wasn’t a night in their marriage where she didn’t sit patiently on the sofa, waiting for him to come back home. Even on the days where he warned her he’d be back a lot later than usual. Regardless, she’d stay plastered to the sofa switching from the tv, to her phone, to a random book-eyes continuously flickering to clock- skipping to the kitchen to shove snacks into her mouth, as she’d never eat without him.

The urge to erupt into a fit of sobs inclined, chewing on her lip violently provided her with enough solace to finish making dinner, feed her daughter and put her to bed. Then at last, when she closed the curtains to her bedroom, a hushed cry escaped her; spending the rest of her night as she did prior, wailing and wailing until fatigue had lulled her weary heart to sleep. The creak of the door went unnoticed to her, Seonghwa crept in; her sleeping figure rested in the bed, the comforter dragged over her head. He sighed, contemplating whether to slip beside her or retreat back to Dami’s room for the night.

This sequence continued for the next few weeks, every night she would cry herself to sleep and Seonghwa would sleep in Dami’s bed. It wasn’t even their room at this point, it was hers with Seonghwa’s things in it-just like her flat pre-marriage. Her room with Seonghwa’s books, few pieces of clothes and odd bits of trinkets. One morning she woke up to find a stack of papers on her nightstand. Fear coursed through her blood, were these the divorce papers that he had suggested to her? Rifling through the papers, her heart soothed as soon as she realised they were just Dami’s crayon drawings. Stick figures of Appa, Amma, and little Dami in the middle. Drawings of flowers, then one just of Amma and Appa, a big heart between them. If only that were true. If only his heart still beat for her the same way hers beat for him.

She heard his voice trail out of the study, as she almost raised her hands to knock and summon him downstairs for lunch. The rapid muttering halted her movements, instead she tentatively pressed her ears against the door to assess the situation.

“Yes, honey, I’ll be there soon…She’s pissing me off right now. I’m trying to get the papers set at the moment…I don’t know about a few more weeks?” Slapping her hand to her mouth, she squeezed her lips shut to prevent any pained sounds from releasing. Honey? There was another woman? And the papers? Was he really, truly, trying to divorce her? Rushing to the bathroom, she slammed the door shut, flipping the tap back open to relive the same endless cycle.

“I’m going on a work trip to Japan, for a week. We have an important business meeting. I might need you take care of Dami by yourself.” His head snapped from up Dami’s unfinished Lego project. She’d fallen asleep when playing, so her father took it upon herself to finish building the set.

“You should have asked me beforehand. You can’t just accept to go offshore, and then give me a week’s notice.” He scolded, playing with the pink block between his fingers.

“I only got told today. I tried to call you whilst I was still in office, but I couldn’t get through to you.” Sighing, his shoulders slumped as he shook his head in disappointment. It appeared that Mrs Park was also refraining important matters from her husband; making decisions of her own that they promised they’d always make together. An uncomfortable silence remained suspended in the tense air, shifting uncomfortably in her spot as she awaited for him to say something else. Even if it was to belittle her, she urged to hear the sound of his voice.

“If you cared enough about me, you’d know I’m busy too.” Chewing down on her lip, she held back a painful sigh. There it is. “We’ll be with my parents for a week while you’re gone. When’s your flight?”

“Sunday night.” Nodding, he scooped up the remaining pieces on the floor pouring them back into the packet before getting up himself. “I’ll pick you up from the airport.”

The work trip to Japan was just as tranquil as she anticipated, the host company was as hospitable as they could be. The days were cut short, the air silent subsiding one into deep thought, even if they denied themselves the pleasures of having to think. With her knees tucked up to her chest, she stared out onto the vast market of skyscrapers, the teeming arena beneath contributing the noises that fell deaf at her ears. She needed to leave the home, its confining airs strangling the lumen of her windpipe. She didn't exactly know what to do now that it was confirmed: Seonghwa did not love her. The declaration was enough to send her into delirium, enough to have her jolting up at night; drowning in cold sweats, preaching his name like a mantra. The flight home did not come soon enough, she boarded the plane with such eagerness and drenched even further in pain when she was assigned the seat next to her colleague and her husband.

Nervously, she dialled in his number once more hurriedly, tapping her feet against the cobbled footpath; her free hand latched onto the sweaty handle of the suitcase. Pick up, pick up, pick up. Being met by the voicemail service was disheartening, wrapping her arms around herself as the wind blew harsh against her skin sending a ripple of goosebumps over her.

"Mrs Park, is your taxi late?" Whipping her head around to find her colleague, she shook her head in dismay. "Do you need a lift? We don't live too far from each other."

Pushing through the large wooden gates of his childhood home, she adjusted the straps of her back pack lifting her head to find the blaring of orange lights through the slits between the window blinds. A small bustle of activity could be heard from the other end, tentatively, her fingers rose to provoke the silver door knocker.

"I'll get the door!" His voice floated through the surface, reaching out to caress the aches on her skin bruised wholly by him. As soon as their eyes met across the doorway, the smile was wiped clean from his lips. “Oh god, I’m sorry, it had completely slipped my mind-,”

“You don’t forget things, Hwa. The truth is: it didn’t slip from your mind, you just didn’t care.” You haven’t cared about me for a very long time. You haven’t loved me in a long time. I am no longer your wife but just Dami’s mother, to you. Though some sort of vile emotion named fear had prevented her from saying those words, becoming lodged at the crux of her throat, floating on the tip of her tongue.

The worst thing was, he didn’t say anything. He was silent, unwilling to reckon against her and fight for their marriage again. When did he become so passive? Up until now, when was there a day in their relationship when he didn’t fight to keep her at his side? Trudging into the household, the warmth lacerated her skin, taking off her shoes as the pattering of small feet came her way. A small body engulfed her larger frame, the delightful giggles of her daughter infiltrated her ears as her mother finally came home to her.

"We ate sooo much food. We had tteokbokki, dakgalbi, ramen. Halmeoni tried to make me eat yaksik but it was nasty." Letting out a tired moan she fell onto the floorboard, Dami crawling on top of her, as her mother-in-law stuffed her with enough food to last her a century.

"Ugh, Dami. Please get off Amma, my tummy is going to explode."

"Halmeoni! Amma ate too much!"

"Your Amma didn't eat enough!" Eomeonim shouted back from the kitchen. Seonghwa ambled into the room settling a cup of green tea in front of her, whilst simultaneously lifting Dami from her stomach. There was an uncomfortable silence amongst them as their daughter, oblivious to the obvious tension between her parents, entertained them nevertheless by dancing around the room and singing. He left the room in between to see to his mother in the kitchen. Feeling terrible for leaving her to tend to the mound of dishes, she carried behind walking straight into the enemy's territory.

“Are you stupid, boy? How could you even suggest a divorce?” She hissed. “It was only yesterday when you came running to me, with your eyes so full of love. Where is that love now?”

“People change.” He deadpanned, hot tears fulfilled her eyes, blurring her vision as she rushed back to the front room.

“We’re going, now!” She ordered, a pout on her daughter’s face grazed the surface of her heart. She couldn’t stand here, and hear her husband declare that he didn’t love her anymore. She couldn’t watch the love of her life slip from the tips of her fingers, whilst she sunk beneath the earth under her feet. She grabbed his car keys, from his jacket. “We’re going home, eomeonim. I need to go into the office, tomorrow. Thank you so much for taking care of Dami.” Kissing the top of her mother’s head, she slipped on her shoes before carrying Dami out of the home. Seonghwa followed hot on her heels.

“Where do you think you’re going at this time of night?”

“Home, Hwa.” The lock clicked out of the place, she jerked open the car door to fasten her daughter into the seat ignoring her cries and pleads to stay at her grandmother’s. “Dami! Quiet!” She roared, the same way Seonghwa would shout at her for nights on end for doing nothing other than being his wife.

“Stop acting like a child and come back inside right now!” He commanded.

“I won’t, Hwa. Because the next time I go back in and let myself be hurt by you, I’ll have no one to blame but me.” He fell quiet, swallowing the heavy lump in his throat. “I am the still the girl who would wait nights for her husband to come home to her. But you are no longer the boy that would walk straight into her arms.” Choking on her sobs, she jerked open the car door to slip inside, her daughter calling out for her father. After all, they were the same woman. Both so utterly in love with the same man that could not love them both in the ways one could dream of being in love. For being in love with him was asking for annihilation, his devotion unreachable like the stars studded in the midnight sky. Was he not made from the stars? An angel borne from light, whose banner was a celestial plane that would diminish the human essence in a heartbeat? Steering the car out of his driveway, Seonghwa stood plastered to the floor a single tear dropping from his eye as he felt his soul meander away from him.

That night, when they reached home, Dami was tight in her arms after having cried the whole journey home from missing her father. Eventually, exhaustion overpowered her and she reluctantly slept in her mother’s arms. She was so sure now that her daughter thought she was the villain for ripping her away from her father. Nuzzling her small face deeper into her mother’s neck, she felt her bottom lip tremble as she called out for her father.

There was no need to frantically run to the post box every time a letter slipped through, meeting the ground with a loud thud. Though, she did it anyway, with little Dami scuttling behind her as if she was expecting a letter herself though deep down Mrs Park knew that she wanted her Appa to come home. It had been a month having not heard back from him. No messages or calls. After work, she ventured over to his office only to be turned away by his assistant; catching a quick glance at his shadow through his window.

“I have to make an appointment to see my own husband?” She uttered through gritted teeth, though the woman in front merely nodded, disinterestedly. “When is Mr Park next available?” The jarring clatter against the keyboard gnawed at her ear drums, annoyance fulfilling her.

Fuck this. Rushing to the handle of his door, she keeled it open storming inside-the loud slam of the door jumping him up from where he sat in his seat. The assistant rushed behind, squawking about how she had to leave.

“Cilla, it’s ok. Go do your job.” He ordered, softly with his eyes fixated on his wife. She didn’t expect him to look this way, the clean, composed Seonghwa now with tousled hair and small dark circles under his eyes. Eyes bloodshot red as if he had been crying for weeks on end, exhaustion piling in them. His sunken face as if he had not eaten for weeks-Seonghwa, not eating? The same man who used to kiss her hands and go for seconds, claiming there must have been some magic in them for she made such delicious food?

“Dami is getting upset. She misses her Dad. The least you could is come home and see her, so she doesn’t think that her father abandoned her too.”

“I’ve been busy-,”

“You’ll always be busy, Hw-Seonghwa. But not busy enough that you can’t spare an hour or two to see your daughter.” She spat, storming straight out of his office, sending the assistant a dirty look on her way to the elevator.

“Appa!” Dami’s animated tone weighed down her father’s heart, his arms wide open as she jumped into them. Fixing her spot by the kitchen doorway she watched as her husband played with her daughter. After a few hours, when they had put Dami to sleep, they sat with each other in the front room Seonghwa pulling out an envelope from his work satchel.

“The-uh- papers. Divorce papers.” A pang struck through her, hands shaking as she reached out for them.

“As her mother, I’ll have custody over her. You should be allowed to see her every week, so maybe the weekend?” Her voice quivered, slightly as she opened up the seal of the envelope, its woody scent wafting up her nose. With little energy, to pull out the form- she settled it onto the coffee table. “We’ll move to my mother’s house…” She trailed off biting down on her lip as Seonghwa closed his eyes shut.

“That’s fine. You can just post it to the lawyer. I’d like to see Dami at my office next week, could you do that?” Nodding diligently, she owed him that much. He’d be counting down the days soon until he’d rarely see his daughter. How would they tell her Amma and Appa weren’t as happy as they were in the drawings?

Her eyes scoured over the woman sat in front of him, as she opened the door to his office. God, she was beautiful with her long, black, silky hair, siren eyes, her chic office look. Everything she was not, though she had managed to pick herself up and put a lot more effort than she usually did with her fitted suit, hair tied back into a sleek bun-held up by the closest pen she could find on her dressing table since her silver claw clip was nowhere in sight. Was she the woman he was going to leave her for? She couldn’t even blame him at this point, why keep something expired when you could throw it away and have something new? Gripping onto the straps of her handbag, she slowly let go of her daughter’s hand who ran to her father’s side.

“Gaeun, this is my wife Mrs Park.” Timidly, she shook her hand. Gaeun saw Mrs Park as an intimidating woman, with her silent face as she ambled into the room with her daughter, her neat hair, pointed heels and tailored skirt that accentuated her curves. She matched Mr Park’s daunting presence perfectly, and of course her intelligence was known to all as well as her insistence to remain at his rivals’ company. “Dear, this is Gaeun- she’s one of the project leads on the next Kim-Park collaboration.”

“I see.” Her head picked up, giving both parties a short nod before leaving the office. She reckoned there was enough to time to make it to her own company and break down in the toilets before beginning the work day.

The rain thundered down from the sky on a solemn afternoon, the clatter of dishes being returned to the cupboards entailing the home; followed the thundering knock at the door. Peeking into the peep hole, she swung the door open, she pulled her husband in immediately rushing around him as he jerked off his shoes.

“Into the shower now.” Without hesitation, he grabbed his clothes from her bedroom before soundlessly making his way into the shower. She only assumed he had come to their home for the signed papers, it had been a while since he’d given them to her; though all she could think about was the way her pen could not even touch the sheet. The door to the study creaked open, as she bit her lip with the unsigned line glaring back at her.

“I haven’t- I haven’t signed the paper, yet.” His breath hitched in his throat, inching closer and closer to her. With the tickle in her throat pervasive, the pen neared the line her heart shattering with every second that her hands rebuked the damned sheet in front. How did she even do her signature?

“I’m sorry that you fell in love with me. I’m sorry that you married me. I’m sorry that I’m not enough. I’m sorry that I couldn’t be the perfect wife for you.” She blurted, the pen falling from her fingers onto the table. He called out her name, drawing forward arms outstretched to encircle her into him. To hold her as tight and as true as she deserved. To fulfil her of kisses that he had deprived her of, to ease her of her pain. Though she stopped him in his tracks, with a palm to censor his movements. “No, Hwa. I haven’t been enough for you for a very long time. I must have done something wrong for you to hurt me like this. I must have done something much worse than what you’ve done to me. I just wished you spoke to me than gave me this stupid sheet and trying to end us in a single heartbeat.” An agonising wail left her lips, as she dropped to the floor tucking up her knees to her chest. Her lungs burned, desperate for air running her fingers through her hair as she slowly breathed out to ease the throbbing sensation loitering at her temples. He sunk to the floor with her, engulfing her frame within his. His jumper so soft, drenched in the scent that she adored. The same scent that he wore when they first met. Her bottom lip quivered again.

“You did nothing, it was all me. I forgot who I was, I forgot it was you who gave me life.” Her tears stained his shirt, he held her closer to his body. “I came to here to change your mind. I didn’t want you to sign those papers. I was so scared you had.” Their bodies rocked back and forth as the painful sound of her sobbing gradually declined.

“I couldn’t do it.” She whispered, her throat sore from this prolonging nightmare. Kissing away her tears, his fingers gently tilted up her head so he could bore his eyes in her beautiful ones. “I just need to know if there’s another woman. If there is, and you love her the same way you loved me, you can have her.”

“There was never another woman. It was always you I swear.” He pledged, as his own tears rushed down his face tickling his jawline before pattering carefully on his sweater. “I was just a poor excuse of a man, a poor excuse of a husband. I admit that I felt like you’d never leave me, but when I realised you really could it hurt me so much.” Drawing lines over his sweatshirt she listened to the sweet sound of his voice whisper into her ears.

“I’ll be a better man. I’ll work on me, and you can just keep on being a great wife and mother.” Their lips met in a frenzy of emotions, their palpitating hearts enamouring their befallen entities as passionate kisses filled the wounds that penetrated through them. His hands snaked around her waist, as hers ran through his long hair emitting a husky groan out of him. “Do you think Dami would like a sibling?” He joked, before being met by whack to the back of his head, they deepened the kiss before she happily rested her head against his chest.

“Maybe, but not now. Right now, you need to come home to us.”

“It’s just you and me now. Nothing’s going to hurt you baby.”

•••

DO NOT REPOST, TRANSLATE, REPURPOSE, OR PLAGISRISE ANY OF THE WORK HERE

cheong meaning 'quiet' 'eomeonim' means mother-in-law (husband's side) 'halmeoni' means grandma

A/N: i'm sorry if the ending seems a bit rushed, i'm going on some meds soon and i have no idea how shit i'm gonna feel while on them. wanted to update in case i have no energy to release something else for a while😖 Hope you guys liked this one! ✨✨

let me know if you’d like to be added to the tag list for any future fics I post!

tags: @n0v4t33z @potatos-on-clouds @jjongwho

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transmutationisms · 6 months ago

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this is probably shaped by my limited frame of reference, but im really fascinated by witnessing the real-time development of adhd as a diagnosis. people attribute so many symptoms to it now or maybe they always did? i was wondering if you have any thoughts on what is the use of adhd specifically as a category within psychiatry. I'm esl so sorry for any confusing wording

no you're right imo; diagnostic categories are always somewhat in flux ofc but ADHD is one that has seen a particularly pronounced shift in the last couple decades. obviously this is multifactorial but my observation goes something along these lines:

'hyperactivity' has been dx'd in children since about the 1950s (also when Ritalin hit the market) but the ADHD dx doesn't really take off until the 90s (also when Adderall, a 2nd-gen reformulation of the 'obesity' drug Obetrol, hit the market). so, it's not all that surprising that 20 years later you see increased patient awareness of the diagnosis, increased popular interest in it, and shifting / expanding ideas of what it means and what ADHD 'is'. it's a relatively young dx.

part of the reason it's young is because it's basically a 'biopsychiatric' dx, meaning it diagnoses certain behaviours as being a 'brain problem' rather than having social causes or context. in practice this is complicated because psychs do use pharmacological approaches in conjunction with psychodynamic ones all the time; nevertheless, the central promise of DSM ADHD and its pharmaceutical treatments has consistently been that the ADHD subject has a physiological, neurological disorder / dysfunction / aberration, and that the drug treatments on the market fix it. that none of this is actually empirically supported is conceptually inconvenient and entrenched by the research process.

the biopsychiatric narrative is worth paying attention to because the context here is one in which it has become commonly accepted that behavioural 'disorders' and affective distress of various kinds can be, basically, either of pure biological origin, or else Your Fault. in the case of childhood hyperactivity, Your Fault historically also included Your Mother's Fault; part of the reason many mothers embraced Ritalin in the 50s and 60s was because the proffered pharmaceutical narrative explicitly challenged the idea that these mothers had done something 'wrong' to result in their (mostly) sons exhibiting disruptive and hyperactive behaviour.

this dichotomy of biology vs personal failing is very overtly present in quite a bit of discourse around ADHD today. if it's my brain being 'wrong' or different, then it's not something I've done wrong but a disease with a simple chemical fix. in this context I don't think it's surprising at all that a lot of popular and patient conceptions of ADHD have seen a considerable widening over the past few decades. often people like to blame this on pharmaceutical companies, and it's true that industry benefits from these discourses and frequently invests in them (eg, via instruments like ADDitude mag). however, that's a pretty simplistic explanation on its own and doesn't really account for the ways in which patients and potential patients also find this diagnostic category personally useful, for reasons ranging from identity-formation to the desire to access prescription amphetamines. ADHD increasingly shows up as a biologised explanation for behaviours ranging from 'eating too many sweets' to 'postural sway' and so on. you can see in such examples how invoking the idea of an aberrant ADHD brain is both reassuring to people who have been made to feel ashamed of certain behaviours, and provides a sense of shared identity and community with others.

all of this is to say: I don't find it surprising at all when I see a relative broadening of notions of ADHD, almost always expressed in biological terms (the 'ADHD brain' operates differently, 'seeks dopamine', causes this or that). ADHD is in some ways a particularly blatant distillation of this general trend in popular psychiatric discourses, for reasons relating to expectations about childhood and child behaviour, and the historical and present relationship between the ADHD label and the regulation of amphetamines. but much of what's happening with ADHD in terms of popular discourses about it can also be seen with many, many other psychiatric diagnoses, to varying extents and in various ways.

my experience writing about ADHD on this website leads me to close by explicitly stating the following: I do not think any ADHD behaviours / symptoms are people's 'fault' or an individual failing; I do not think using drugs for any reason is morally bad or needs to be justified; the fact that I do not think ADHD is a 'brain disease' does not mean I think people are 'making it up' or exaggerating wrt any difficulties they experience personally, professionally, emotionally, &c.

#psychiatry

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naamahdarling · 4 months ago

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Maybe it isn't that I actually hate medical professionals? They just suck and are weird sometimes, and a lot of them shouldn't be practicing, but I don't hate them as a group, like, personally.

What I hate is their ability to make my life harder in ways that are often completely opaque to me, and a lot of the crap things they do are not really possible to challenge. And I hate the fact that holding them responsible fort dogshit behavior in any way that will actually benefit me is almost always impossible.

And I also hate the fact that they have to do stupid things sometimes because that's how the system is set up, and those things sometimes mean patients actually get harmed. They aren't fond of that part either! They don't want the system to be the way it is! But they don't have a choice, so sometimes people like me get forced by bureaucracy into doing things that are re-traumatizing. And I can't imagine that feels good for them at all, knowing that their patients are sometimes only "consenting" because that bureaucracy will not let them be helped in any other way. Which isn't consent at all. I imagine that must be pretty traumatizing for them, too, sometimes.

If it were easier to actually access medical care without tremendous delays in this country right now I would have much less trouble finding providers who are good at what they do and are not horrible people, and who have clinic staff who can do their fucking job.

Oh and I also don't appreciate how evasive and unwilling to commit they are out of fear of being held to an answer that turns out to be inaccurate, but I can't make an informed decision about my own care unless they give me at least some information about probabilities and trajectories and typicalities. Genuinely, how the fuck am I supposed to navigate that shit. I get that some patients are really fucking difficult, but I should be able to get a special stamp on my file or something that says I understand that sometimes medicine isn't an exact science and the best answers that my doctors can give may not always prove to be accurate in the long term. I know they don't like being in that situation either.

A lot of medical professionals are fucking assholes, and unfortunately the ones who are not are still hamstrung by a system set up to actively prevent people from getting care.

I miss my old doctor. He gave no shits about anything that wasn't the patient. He prescribed scheduled meds based on what the patient needed and not based on fear of consequences potentially being imposed on him by the punitive patient-hostile drugs-are-bad moral panic machine developed to force suffering people into buying more dangerous drugs off the street in order to prevent far fewer people from maybe getting high off of drugs that at least weren't laced with lethal substances. (The purpose of a system is what it does.) Did he get sanctioned and become locally unhireable? Unfortunately yes he did. Does he now provide concierge care to rich people? Yes he does. He found a way to make it work, God bless him.

Everything about the medical system in this country is fucked. Hospitals, doctors, nurses, pharmacies, pharmacists, pharmacy techs, phlebotomists, clinic administrative staff, insurance companies, medical schools and schooling, licensing boards, drug advertising to both providers and patients, pharmaceutical reps, researchers, research, publishing, medical trials, pharmaceutical companies, manufacturers and distributors, medical equipment, charting software, billing and billing codes, diagnostic criteria, charity and low income services, accessible transportation, home care, the lack of independent individual patient advocates, dietitians and nutritionists, access to physical and occupational therapy and physical and occupational therapists, the massive bigotry of every kind rampant in every corner of the medical field, social work, senior care and assisted living, deprioritization of informed consent and harm reduction, disability applications, inaccessibility of medical records, especially psychiatric notes which are specifically allowed to be withheld from patients, lack of continuity of care for disadvantaged people, care that is equitably accessible to disabled people, telemedicine, patient portals, phone systems, clinic hours, every single aspect of inpatient and outpatient psychiatry, facility security, all sorts of things going on with therapists who are nevertheless probably the least malicious group of people in this entire charade, aaaaaand patients themselves.

Also hospital toilets that are too tall and make it literally physically impossible for me to poop while I'm there waiting for somebody to come out of surgery. I just needed to take a crap, guys. You didn't need to make the toilets so tall that my feet didn't even touch the floor. It is very clean but there is no shitting for short people at St Francis.

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chemxpert · 30 days ago

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Caffeine in the USA | Chemical Properties, Market Size, and Regulatory Landscape

Caffeine is a familiar friend whose usefulness can hardly be overestimated, it is taken in the morning and during working hours to prevent the sense of fatigue. This psychoactive stimulant used in drinks as coffee, tea, energy drinks and in various dietary supplements has attracted consumers worldwide. It is a complex compound, which has a multi-faceted role in our daily lives, that is why caffeine an indispensable part of our diets and a major component in the global economy. In this blog, we look at the basic details about caffeine including its chemical properties, the growth in global market size over the years and the current rules governing it in the United States.

#medicine export from India #new drug development process #api medicine #clinical research companies in India #latest trends in pharmaceutical industry

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octanexlabsin · 21 days ago

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OctaneX Labs is committed to developing sustainable and environmentally friendly chemical solutions. Our focus on research and development ensures that our products meet the highest standards of quality and sustainability.

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ephemerensis · 4 months ago

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Cologne // Tim Drake x GN! Reader

hay guys! where Tim Drake and Red Robin (ur bodyguard for the time being) smell suspiciously the same— it’s like you can’t even tell the difference! no angst, this took me so long oh my goodness i’m gonna stick to writing what i know. stay tuned for hurt/angst i have a lot of grievances to spit out! not proofread.

Part 2

—

Gotham was the last place you’d expected to be sent off to, but it’s where you found yourself now. Despite being disgustingly crime ridden, it was the center of trade, commerce, business, and more importantly— information. Which is precisely what you’d been sent to offer.

Your family’s company recently made a ground breaking discovery in pharmaceuticals, creating a drug that could limit the spread of cancer cells without traditional side effects; YB-V they called it. However, the by-product of production was much more severe, resulting in a chemical compound capable of mutating all the cells in a person completely to become something other as if they belonged to a different entity. Given the right motivations and means, the cells could be manipulated by a third party, turning them into fully conscious puppets of some sort.

With data leaks and security concerns, and the serious nature of the consequences if your drug had fallen into the wrong hands, you were sent to deliver the research and development to the production team personally; placed in charge of overseeing production until launch.

Which all sounded good in theory, but as you found yourself twiddling your thumbs in a blacked out office space, getting briefed on the gravity of the situation by a police task force with some vigilante character hanging around behind you, you began to question what it was all worth.

“So let me get this straight, an email between Wayne Corp and ourselves was leaked and now a couple big shot villains want to steal it? What kind of bad guy reads emails?”

A burly officer with a thick white mustache and a pair of square set glasses cleared his throat awkwardly, “That’s correct.”

“Some tech team,” you scoffed. “I’m the only one that can access any of the files, it’s all biometrically locked. While this certainly puts a damper on my day, we should be able to proceed normally.”

“They have your identity too,” the figure in the back voiced. Red Robin, you’d been informed, one of Gotham’s crime fighters in spandex (allegedly.) Up until now he hadn’t spoken a word, loitering while the police explained everything to you.

“Which is why we brought you here,” the commissioner pipped, reaching for his coffee mug as he spoke. “Red Robin has agreed to watch over your activities for the duration of your time in Gotham. For your safety, and ours.”

Have this guy tail you? As if. You were occupied enough without having a stranger watch your every move. A vigilante at that, it’s not like you could look at his resume and review his history.

“While that is a gracious offer, I have my own bodyguards. They’re well trained and—“

“Not for Gotham, you don’t.” Red Robin stepped out from the corner he’d situated himself in, arms crossed and a frown plastered on his face. “And unless you want to stay in a bunker for three months, I’m your best bet.”

Silence fell as you stared at the masked man, contemplating your options. The underground bunker was out of the question. On top of running production, you had a company to run and a reputation to upkeep; meetings, galas, charity events to attend. And as much as you hated to admit it, they had to be right. Gotham knows Gotham, and with the crises you’d witnessed on screen it was clear their criminals were on a polarly different level.

Pressing your hands to the table, you stood up and turned around, “I see. And you being around won’t make me more of a target?”

“Not even you would know I’m there.”

Closing the distance between the two of you in a few paces, you stuck your hand out to him, “In that case, I look forward to working with you Red Robin.”

Standing near him, the faint smell of lavender was imminent and something deeper lingered under it, an amber of some sort. It was pleasant; Red Robin had good taste in cologne. And that is all you needed to trust him.

It took a second for him to shake your outstretched hand. In your palm, his grip was firm, rough gloves pressing into your satin skin. Secure, you’d decided, secure and reliable.

And just as he’d promised, you hardly noticed him. On the contrary, you were also never attacked; not in the days following the abrupt meeting, nor the week after that, nor the month after that. There was the occasional mention of trouble, or something that went bump in the night— but whether it concerned you or not it didn’t matter. Nothing ever happened.

When he was tucked away it felt like he was really gone, not even the eerie feeling that followed being watched lingered. The only thing that drew you back into the reality was when you’d catch the scent of lavender lingering or in the few cases where he’d appear before you. In his absence you felt almost lonely, despite your work occupying it all. So you soon found yourself leaving notes.

“Bought coffee for the office.”

And he began to write back.

“Just black next time, thanks.”

…

“What’s your favorite color?”

“Cornflower blue.”

“That’s a dumb name. Your costume is red, I think you got out branded by Nightwing.”

“In my defense, I didn’t design it.”

…

He didn’t say much in them, nothing that you could glean in depth anyway. But you found yourself oddly pleased with his nothing. It’s not like you cared so desperately for his identity, that was his to keep of course. You did care for his presence. Something about it was magnetizing, and because he hardly appeared before you, these were the tidbits you found yourself drawn to.

Not that you’d kept them, he would see. Despite knowing the situation you were in, it still felt like a strange game— where he knew every detail about you, and you knew nothing of him. Your feelings, at the least, these you could keep on your own.

“Do you need lab access? I know you follow me in, but if there’s an emergency or something…” Production and distribution for YB-V was run by Wayne Corp and like all things related to your project it was kept secure in an underground bunker while you worked to transfer the information your company developed.

While the scientists and developers were mainly in charge of carrying out the project, none of it could move forward without you. The security system had been meticulously set up so that you, and only you, could access the files with the research and instructions. And beyond even your capabilities, every stage written into the plan had to be completed before the next could be unlocked. So you had to be there, supervise and guide them during the entirety of the process.

Archaic, you’d decided. But necessary according to the rest of the world.

Red Robin accompanied you on these trips. Being underground and all, it was one of the few moments he went with you rather than watching from afar.

“No, I’ll find a way in if I need a way in.”

You looked back at him questioningly. You didn’t doubt his capabilities of course, but he said it with such ease, “Is it that easy to break into? I should increase security.”

He scoffed, crossing his arms. “It’s secure. I’m the issue.”

You turned back around shaking your head with a snort. He was growing on you, sass and all. Stopping by a display of notes and charts, you looked them over to ensure they aligned with protocol.

“I have to attend a gala next week, by the way.”

He hummed in response, a couple steps behind you like he usually was when you visited the lab.

“It’s at Wayne Manor… and I can get you an invite. Security is stricter than it is here, I’ve been told. It’d be troublesome to sneak around.” Ruffling through the papers, you extracted the one you needed, holding it up to your face.

“And I don’t have a date,” you added.

“…are you asking me out?” You could hear a hint of a smile in his voice, making your face burn red at the accusation.

You set the paper down, abruptly whipping around with the most serious expression you could muster, “Strictly for my safety! I don’t know how credible everyone attending is and—“

The smile on his face shut you up. Embarrassed and slightly dejected you looked around the room for something else to lock eyes on, clearing your throat.

“I would’ve loved to, but I won’t be there. Something came up that I need to take care of. But like you said, security is strict, you’ll be safe,” he interjected before you could say anymore. Honestly you couldn’t even be mad, he let you down so sincerely you had to believe it. The small smile plastered on his face and the gentle tone he used in opposition to his usual curt one melted you down far more than you would’ve liked it to.

“Right.” It took you a second to cough anything out, like you were thirteen and starstruck again by any character that tossed you a bone, “so much for you or the bunker, I could’ve hired the Waynes’ security.”

But you were disappointed, and his answer did surprise you. Busy? He hadn’t left your side your entire stay as far as you were aware, granted you couldn’t see him 95% of the time, but in principle.

He must’ve picked up on your downtrodden state because he leaned in teasingly, that familiar lavender scent washing over you, “You have your own bodyguards though, right? They’re well trained.”

You wondered what color his eyes were behind the mask, a warm brown or a melancholy blue. Either way you’d decided you were done for, his were the type of eyes you could drown in; “Not for Gotham, I don’t.”

The night of the gala you didn’t expect much. You were supposed to represent your company of course, as their Gotham socialite, and you were to meet with your business partner. Up until now everything had been transactional, taken care of on invisible ends. Which was fine, but to maintain business relations you had to show up to these things.

And so it was about as dry as you’d thought it to be. Most of everyone was twice your age, many were so stuck in their desire for affluence it radiated off of them like maggots in a burn pile. Supposedly it was a charity gala, in reality it was an egoistic echo chamber and you were in no position to defy it.

Flitting around you sipped your champagne and made conversation and promises that didn’t matter until a hand graced your shoulder with the lightest touch, it felt almost invisible. Turning around you saw a boy with raven hair and the tamest of blue eyes. And he looked to be around your age, a moment of respite at last.

“Hi,” he breathed the word into a smile that was dazzlingly honest and strikingly warm in juxtaposition with the mood of the room.

“Hi,” you shook the hand he offered to you. His hands were rougher than you’d imagine an aristocrat’s to be, littered with callouses you attributed with a dedication to some sport, “I’m Y/N, I don’t think we’ve met before?”

“Sort of, I’m Tim.” In your correspondence with Wayne Corp, Tim had been your main contact; at least for big ticket decisions. In other words, he was your collaborator and your business’ partner. In your head you recalled all the times you poked fun at the archaic way he wrote his emails, like he was 52 and balding— in reality he was just the opposite.

“Oh! It’s nice to finally meet you! Thank you for working with us, we couldn’t have progressed this far without Wayne Corp.”

“On the contrary, thank you for trusting us. This project’s been a huge safety concern for you I’ve heard.”

You laughed, shaking your head, “Not at all! I have one of the best vigilantes in the city.” But this, he should’ve already known. Red Robin had to be cleared for access to certain things, and you’d corresponded as much through your emails. “I must say though, I was disappointed it wasn’t Nightwing at first, he used to be my favorite.”

Tim blinked at you for a spell and you couldn’t read his expression. Pleasant and cordial with some twinge of underlying distaste was the best way to describe it, something in the way his eyes glinted with a malice behind his smile. “Has that changed?”

He must love Red Robin.

“I suppose,” growing on you was an understatement. It was a strange ordeal because he wasn’t real. No name or title you could address, but everything you learned about Red Robin made you want to know more about Red Robin. He was magnetizing. “Have you met them? Is it a normal Gotham thing?”

“No,”his response came swiftly, “they’re usually in other parts of the city and I’m never out at night. Married to the office.”

“I see.” That would explain the emails.

“Do you… want to dance?” He extended his hand to you graciously, but with a gentle hesitance that made him seem softer than he was. In a way you felt like you were betraying your vigilante delusionship, but he hadn’t agreed to go with you and Tim was charming enough. Besides, business relations.

“Of course.” Placing your flute of champagne on a nearby table, you took his arm as he led you to the floor. He smiled in a demure sort of way that made your heart flutter like the excitement you’d felt interacting with Red Robin. Maybe you just liked the attention that much, that must be the correlation between the two.

“Do you know how to waltz?” Typically galas didn’t have much dancing at all, let alone organized ballroom dancing, but leave it to the Waynes to find a way to stun the crowd with their class and extravagance.

“Sort of, I’ve taken rudimentary classes.” Like when you were five.

“Perfect,” he grinned. He placed his hand faintly on the small of your waist while the other found purchase in your opposing palm, “I’ll lead. Just follow along, you’ll be fine.”

Miraculously you were fine. You started out with your eyes glued to the floor, following after him and avoiding his toes. But once you’d gotten into a rhythm, it all felt like floating.

“You haven’t stepped on my toes once,” he joked. Up close and under the mesmerizing ballroom light he looked angelic, the way the light caught in his lashes and the reflected off the blue of his eyes—like little golden flecks glimmering under supple flowing rivers.

“I’ve been trying not to!” you laughed.

“You look beautiful,” as if his eyes could get any more mesmerizing, they softened somehow with his words, “outfit and all.”

“Thank you,” at this you averted your gaze, and prayed the lighting didn’t highlight the flush of your cheeks. Out of being flustered or embarrassment, you didn’t know. On the one hand, a rich, beautiful, respectful man was complimenting you. On the other, you were wearing cornflower blue because it was someone else’s favorite color. Like you were twelve again and going to some middle school dance where you wanted to impress your hallway crush.

“Your Getty pictures don’t do you justice,” he continued. “Don’t get me wrong, I haven’t seen one bad photo, but you always look so serious and intimidating.”

It never occurred to you he’d Googled you before, it made sense now how he was able to single you out in the crowd. Maybe the thought was so foreign because you’d never paid him any mind, but now you were thinking you should’ve. At the very least because it’s polite and helpful to know the bare minimum, but if you were honest with yourself it’s because he struck a curiosity in you that needed to be sated—too breathtaking to be real and all you’d known was his face and arresting demeanor.

“Because I am serious and intimidating, I’m very good at my job you know. You’re not the only one married to an office,” you boasted. In reality you hated work, but worse still was posing for pictures. Especially at crowded social functions your parents ushered you to where you didn’t know a soul, you simply didn’t know what to do with yourself in front of a camera—that was your excuse anyway.

“That explains the dancing,” he quipped with a sideward smile.

Your eyes widened slightly in shock as your mouth fell open to scoff. “Hey! I thought I was doing pretty good!”

He burst into a contagious laughter that hypnotically made you follow suit. But you wouldn’t settle for that after all your efforts to keep up. With a look to the wayside, you pretended to lose touch of the tandem between your steps and lurch forward, consequently stepping on his polished brown loafers. And then it was his turn to be shocked.

“Woah! So much for trying,”Tim teased. Not that he lost his footing, he was as stable as ever. In his eyes you swore there was a glint of mockery, as if he knew and anticipated it.

“Oh did I hurt you,” you feigned concern before slipping into the most innocent smile you could muster. “I’m a terrible dancer, I can’t help it.”

“Aren’t you petty?”

“You have no idea.”

“Petty and pretty, how dangerous.”

Before you could fire some witty retort you noticed your steps slowing to a halt with the swoon of the music. He’d brought his hand above you to spin you once, slowly. The other on your waist moved to your lower back to support you as he pulled you into a dip and all you could do was follow. Something about the atmosphere had your heart palpitating. Or maybe it was the way he was looking at you, like you were an art piece on display, overhead light illuminating behind him as he stared down at you like an angel emerging from the heavens.

Sundering you to the earth, you couldn’t fixate your eyes on anything else, and though it was only for a moment it felt like eternity. You were close enough now for the scent of his cologne to waft over you faintly amongst the throng of strongly powdered people in the room. Lavender. A familiar lavender with all the base notes that’d been lingering around you for the past few weeks. Your look of awe faded to confusion.

Red Robin’s.

“Is that—“

But he wasn’t looking at you. Instead you followed his gaze down to your chest, eyes widening as you saw the little red laser mark hovering over your heart. Before you could react, you felt the air get knocked out of your lungs as Tim shoved you away. The sound of the gun firing pierced cleanly through the noise of the glitz and glamour, and something burned across the skin of the side of your arm.

You couldn’t tell if it was broken glass that cut you or something else, you couldn’t feel much of anything with the adrenaline flooding your body. Scared and discombobulated, you scrambled backwards as panic set into the crowd.

In the midst of the onset of gunshots and people scattering towards exits, Tim had rushed over to you. Kneeling beside you, he gave you a quick look over and gently pulled you up by your uninjured arm. As soon as you were up he rushedly dragged you away from it all, winding through the hallways of the manor wordlessly. Though it was probably for the better, because you didn’t have an ounce of air left in your lungs trying to keep up with his pace or a thought in your head after what you’d just witnessed.

The further you trudged along, the heavier your limbs felt and the harder it was to pry your eyes open after blinking. Which was strange, you hadn’t lost so much blood, but it must’ve been the confusion of it all or something you ate. A couple halls and turns later you arrived at a room. He ushered you inside, seating you on the bed before rummaging through the drawers.

“Are you alright? Does it hurt badly?” from the drawer he procured a bandage. He sat himself next to you, promptly wrapping the cloth tightly around your arm.

“No, it’s not bad,” truthfully it felt numb, which you couldn’t decide was a good or bad thing. You couldn’t think much of anything, focused on keeping your eyes from fluttering shut.

“I should’ve known they’d do something,” he’d muttered. As he finished, pushing himself off the bed, your head suddenly felt too heavy to hold up and your eyes too tired to function.

“Hey… are you okay? You don’t look so good.” He pressed the back of his hand to your forehead, feeling nothing abnormal and deepening his concern. But you couldn’t process what he was saying. With a lilt, you fell to your side, feeling the injunctive relief of not having to hold yourself upright.

He undid your bandages to look at the wound again before scowling as it dawned on him, “Tranquilizers.”

After rewrapping your arm, he hurriedly stalked towards the door, “You’ll be safe here, I’ll send someone.”

With whatever consciousness you had left you managed to slur a sentence, “Where are you going?”

“To find my brother.”

If he said anything after you didn’t hear it, because the moment your eyes fluttered shut, they stayed shut.

You didn’t know how long you were out. Not terribly so. When you’d awoken, it was still dark out. Tim must’ve flicked the light off when he’d left too, the only light that flooded in was from the streetlamp out the window. The drugs hadn’t cleared your system yet if the pounding in your head and brain fog you were experiencing was any indicator. And they didn’t even hit you directly, who knows where you’d be if they did.

In the streets you could hear the panic of people and the wail of police sirens, which would’ve settled your stomach if not for the fact that it clearly wasn’t over and the police weren’t entering.

You jerked your head towards the door as a loud thud sounded just outside of it. Looking around the room for a place to hide, there was none. And if there was one, you couldn’t see it with the lights out. Some commotion followed before what sounded like a body hit the floor.

Not knowing what else to do, you wrapped yourself in the bedding, pulling it to the floor behind the bed and huddling there. At the very least, no one knew you were in there but Tim, and surely he’d locked the door.

Nope.

The sound of the knob turning made your blood run cold. You drew the blankets tightly around yourself, hoping you’d amalgamate into the cloths if you’d clutched them tightly enough.

With the bed obscuring your view, you couldn’t see the perpetrator and you didn’t want to. You screwed your eyes shut as footsteps creaked on the wood pacing towards you. Against your will, you hands couldn’t cease trembling and you wondered if the other person in the room could hear your heart beating out of your chest.

This was it. If someone wanted to swoop in, now would be great.

The footsteps halted on the opposite side of the bed. You considered jumping out at them, throwing the blanket and bolting for it, but your limbs felt like they were filled with lead. And in any case, if they were armed you were done for anyway. So you held your breath and willed them away instead.

To your horror they’d started again in your direction. Silence. And then a hand touched the blanket and you couldn’t help it, you shrieked and covered your head with your arms.

But instead of force or a bludgeoning, they’d knelt in front of you, gently grabbing your arms as you thrashed. A familiar voice called your name out a couple times before you recognized it and opened your eyes.

“Hey, hey, hey, it’s me! You’re okay,” in the dark you couldn’t really see his face but it was Tim’s voice that called to you. Delirious and reeling, the relief flooded your body so intensely, the tears didn’t even have time to well before they were streaming down your cheeks.

Throwing your arms around him, you sobbed for all you were worth, “I was so scared, why’d you just leave me!”

You felt him stiffen beneath you at the sudden intrusion before softening and patting the back of your head with a gloved hand. “I’m sorry,” he whispered.

And it felt so safe there, in his arms, secure but soft all at once. The familiar lavender mixed with the champagney smell from the gala soothed you in a way you’d never thought you’d needed.

“I thought they were gonna get me,” you choked out between sobs. This was in no way attractive, “and then I’d get kidnapped, and everyone would turn into puppets!”

“I’m sorry,” he said again. Not mocking or laughing at you like your more awake self would’ve expected, he was mellow about the whole thing. Sorry and really sorry for it—and it wasn’t even his fault.

When you calmed down enough to sound coherent, he pulled back to wipe the tears from your cheeks.

“Let me see that,” he nodded towards your bandaged arm. You stretched it out for him and he undid the gauze, “This doesn’t look too bad. Shouldn’t scar.”

Procuring new dressings, he took his time with it this time, applying a salve before wrapping it around you again.

“Tim?” you said his name just to say his name, because you liked the way it felt to say and you wanted to hear him speak. Instead he paused before resuming his work, “I’m Red Robin.”

“Oh.” That’s embarrassing. You were so certain of it too, but he did say he would send someone and he was probably with his family or waiting outside for things to settle. So instead you got the infinitely intangible Red Robin, “I thought you were busy.”

“Plans changed.” He was never this curt with you, not after knowing you anyway. He had to maintain secrecy, you knew this, but he’d find ways to say more anyway.

You flinched as he constricted your arm with the bandage, “You’re pulling it a little tight.”

This made him pause again, letting go of the wrap altogether this time as the circulation breathed back into your marrow.

Exhaling, he ran a hand through his raven hair, “I’m sorry.”

You blinked at him, still fighting to keep your eyelids open but worried nonetheless. This was unlike him, “Red?”

“Sorry, I’m just on edge. I should’ve known, I could’ve prevented this,” shaking his head, it was if he made up his mind, “Everything is transferred now, the project can wrap up without you. We’ll get you on the next flight back tomorrow.”

Somewhere in you an inkling of anger stirred, as if you were an object that could be sent as needed. But the strain in his voice was evident, how could hold a grudge against that? “I don’t want to leave yet.”

“You’re going.”

You huffed, “I’m not. And you don’t have to watch me anymore if it’s too much, I never expected that from you! You’re here now, you didn’t have to be, but you are— that’s more than my useless bodyguards or Wayne security have done and they’re paid for it. You put up with me and nothing has happened to me. I’m sorry for being so vulnerable, that’s my fault. Don’t you dare berate yourself, you haven’t done one wrong thing!”

He said nothing, just stared at you with something like curiosity. Under the pale moonlight and with his face obstructed you could only speculate.

You stuck out your injured arm to him again, urging him to take it, “Hurry and finish, I’m still sleepy.”

Wordlessly he finished binding your arm. As soon as he was done you fell on his shoulder, closing your eyes.

“Tim—“

“I’m not Tim,” he reiterated. There was something in his tone that you couldn’t quite place; annoyance?

“Oh,” you mumbled, feeling sleep creep up on you again, “you smell the same... I think I like him.” Surely it’s fine to confess this much, or that’s what you told yourself as you started to drift off, words slurring and thoughts blurring, “you should meet him, he’s a big fan.”

—

i have a final in 5 hours please with me luck (it’s 2am)

#tim drake fanfic #tim drake #batman #dc #tim drake x reader #red robin x reader #tim drake x gender neutral reader #tim drake fluff #tim drake imagine #bodyguard trope #i can’t write like this #stick to what you know

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covid-safer-hotties · 2 months ago

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also preserved on our archive

by Rowan Walrath

Public and private funding is lacking, scrambling opportunities to develop treatments

In brief Long COVID is a difficult therapeutic area to work in. It’s a scientifically challenging condition, but perhaps more critically, few want to fund new treatments. Private investors, Big Pharma, and government agencies alike see long COVID as too risky as long as its underlying mechanisms are so poorly understood. This dynamic has hampered the few biotechnology and pharmaceutical companies trying to develop new medicines. The lack of funding has frustrated people with long COVID, who have few options available to them. And crucially, it has snarled research and development, cutting drug development short.

When COVID-19 hit, the biotechnology company Aim ImmunoTech was developing a drug for myalgic encephalomyelitis/chronic fatigue syndrome, better known as ME/CFS. As more people came down with COVID-19, some began to describe lingering problems that sounded a lot like ME/CFS. In many cases, people who got sick simply never seemed to get better. In others, they recovered completely—or thought they had—only to be waylaid by new problems: fatigue that wouldn’t go away with any amount of rest, brain fog that got in the way of normal conversations, a sudden tendency toward dizziness and fainting, or all the above.

There was a clear overlap between the condition, which patients began calling long COVID, and ME/CFS. People with ME/CFS have a deep, debilitating fatigue. They cannot tolerate much, if any, exercise; walking up a slight incline can mean days of recovery. Those with the most severe cases are bedbound.

Aim’s leaders set out to test whether the company’s drug, Ampligen, which is approved for ME/CFS in Argentina but not yet in the US, might be a good fit for treating long COVID. They started with a tiny study, just 4 people. When most of those participants responded well, they scaled up to 80. While initial data were mixed, people taking Ampligen were generally able to walk farther in a 6 min walk test than those who took a placebo, indicating improvement in baseline fatigue. The company is now making plans for a follow-on study in long COVID.

Aim’s motivation for testing Ampligen in long COVID was twofold. Executives believed they could help people with the condition, given the significant overlap in symptoms with ME/CFS. But they also, plainly, thought there’d be money. They were wrong.

“When we first went out to do this study in long COVID, there was money from . . . RECOVER,” Aim scientific officer Chris McAleer says, referring to Researching COVID to Enhance Recovery (RECOVER), the National Institutes of Health’s $1.7 billion initiative to fund projects investigating causes of, and potential treatments for, long COVID. McAleer says Aim attempted to get RECOVER funds, “believing that we had a therapeutic for these individuals, and we get nothing.”

Instead of funding novel medicines like Ampligen, the NIH has directed most of its RECOVER resources to observational studies designed to learn more about the condition, not treat it. Only last year did the agency begin to fund clinical trials for long COVID treatments, and those investigate the repurposing of approved drugs. What RECOVER is not doing is funding new compounds.

RECOVER is the only federal funding mechanism aimed at long COVID research. Other initiatives, like the $5 billion Project NextGen and the $577 million Antiviral Drug Discovery (AViDD) Centers for Pathogens of Pandemic Concern, put grant money toward next-generation vaccines, monoclonal antibodies, and antivirals for COVID-19. They stop short of testing those compounds as long COVID treatments.

Private funding is even harder to come by. Large pharmaceutical companies have mostly stayed away from the condition. (Some RECOVER trials are testing Pfizer’s COVID-19 antiviral Paxlovid, but a Pfizer spokesperson confirms that Pfizer is not sponsoring those studies.) Most investors have also avoided long COVID: a senior analyst on PitchBook’s biotech team, which tracks industry financing closely, says he isn’t aware of any investment in the space.

“What you need is innovation on this front that’s not driven by profit motive, but impact on global human health,” says Sumit Chanda, an immunologist and microbiologist at Scripps Research who coleads one of the AViDD centers. “We could have been filling in the gaps for things like long COVID, where pharma doesn’t see that there’s a billion-dollar market.”

The few biotech companies that are developing potential treatments for long COVID, including Aim, are usually funding those efforts out of their own balance sheets. Experts warn that such a pattern is not sustainable. At least four companies that were developing long COVID treatments have shut down because of an apparent lack of finances. Others are evaluating a shift away from long COVID.

“It is seen by the industry and by investors as a shot in the dark,” says Radu Pislariu, cofounder and CEO of Laurent Pharmaceuticals, a start-up that’s developing an antiviral and anti-inflammatory for long COVID. “What I know is that nobody wants to hear about COVID. When you say the name COVID, it’s bad . . ., but long COVID is not going anywhere, because COVID-19 is endemic. It will stay. At some point, everyone will realize that we have to do more for it.”

‘Time and patience and money’ Much of the hesitancy to make new medicines stems from the evasive nature of long COVID itself. The condition is multisystemic, affecting the brain, heart, endocrine network, immune system, reproductive organs, and gastrointestinal tract. While researchers are finding increasing evidence for some of the disease’s mechanisms, like viral persistence, immune dysregulation, and mitochondrial dysfunction, they might not uncover a one-size-fits-all treatment.

“Until we have a better understanding of the underlying mechanisms of long COVID, I think physicians are doing the best they can with the information they have and the guidance that is available to them,” says Ian Simon, director of the US Department of Health and Human Services’ Office of Long COVID Research and Practice. The research taking place now will eventually guide new therapeutic development, he says.

Meanwhile, time marches on.

By the end of 2023, more than 409 million people worldwide had long COVID, according to a recent review coauthored by two cofounders of the Patient-Led Research Collaborative (PLRC) and several prominent long COVID researchers (Nat. Med. 2024; DOI: 10.1038/s41591-024-03173-6). Most of those 409 million contracted COVID-19 and then long COVID after vaccines and antivirals became available. That fact undercuts the notion that the condition results only from severe cases of COVID-19 contracted before those interventions existed. (Vaccination and treatment with antivirals do correlate with a lower incidence of long COVID but don’t prevent it outright.)

“There is that narrative that long COVID is over,” says Hannah Davis, cofounder of the PLRC and a coauthor of the review, who has had long COVID since 2020. “I think that’s fairly obviously not true.”

The few biotech companies that have taken matters into their own hands, like Aim, are often reduced to small study sizes with limited time frames because they can’t get outside funding.

InflammX Therapeutics, a Florida-based ophthalmology firm headed by former Bausch & Lomb executive Brian Levy, started testing an anti-inflammatory drug candidate called Xiflam after Levy’s daughter came down with long COVID. Xiflam is designed to close connexin 43 (Cx43) hemichannels when they become pathological. The hemichannels, which form in cell membranes, would otherwise allow intracellular adenosine triphosphate (ATP) to escape and signal the NLRP3 inflammasome to crank up its activity, causing pain and inflammation.

InflammX originally conceived of Xiflam as a treatment for inflammation in various eye disorders, but after Levy familiarized himself with the literature on long COVID, he figured the compound might be useful for people like his daughter.

InflammX set up a small Phase 2a study at a site just outside Boston. The trial will enroll just 20 participants, including Levy’s daughter and InflammX’s chief operating and financial officer, David Pool, who also has long COVID. The study is set up such that participants don’t know if they’re taking Xiflam or a placebo.

Levy says the company tried to communicate with NIH RECOVER staff multiple times but never heard back. “We couldn’t wait,” he says.

Larger firms are similarly disconnected from US federal efforts. COVID-19 vaccine maker Moderna appointed a vice president of long COVID last year. Bishoy Rizkalla now oversees a small team studying how the company’s messenger RNA shots could mitigate problems caused by new and latent viruses, including SARS-CoV-2. But Rizkalla says Moderna has no federally funded projects in long COVID.

Federal bureaucracy has slowed down research in other ways. When long COVID appeared, Tonix Pharmaceuticals was developing a possible drug called TNX-102 SL to treat fibromyalgia. The two conditions look similar: they’re painful, fatiguing, and multisystemic, and fibromyalgia can crop up after a viral infection.

But it wasn’t easy to design a study to test the compound in long COVID. Among other issues, the US Food and Drug Administration initially insisted that participants have a positive COVID-19 test confirmed by a laboratory, like a polymerase chain reaction test, to be included in the study. At-home diagnostics wouldn’t count.

“We spent a huge amount of money, and we couldn’t enroll people who had lab-confirmed COVID because no one was going to labs to confirm their COVID,” cofounder and CEO Seth Lederman says. “We just ran out of time and patience and money, frankly.”

Tonix had planned to enroll 450 participants. The company ultimately enrolled only 63. The study failed to meet its primary end point of reducing pain intensity, a result Lederman attributes to the smaller-than-expected sample size.

TNX-102 SL trended toward improvements in fatigue and other areas, like sleep quality and cognitive function, but Tonix is moving away from developing the compound as a long COVID treatment and focusing on developing it for fibromyalgia. If it’s approved, Lederman hopes that physicians will prescribe it to people who meet the clinical criteria for fibromyalgia regardless of whether their condition stems from COVID-19.

“I’m not saying we’re not going to do another study in long COVID, but for the short term, it’s deemphasized,” Lederman says.

Abandoned attempts Without more public or private investment, it’s unclear how research can proceed. The small corner of the private sector that has endeavored to take on long COVID is slowly becoming a graveyard.

Axcella Therapeutics made a big gamble in late 2022. The company pivoted from trying to treat nonalcoholic steatohepatitis, a liver disease, to addressing chronic fatigue in people with long COVID. In doing so, Axcella reoriented itself exclusively around long COVID, laying off most of its staff and abandoning other research activities. People in a 41-person Phase 2a trial of the drug candidate, AXA1125, showed improvement in fatigue scores based on a clinical questionnaire (eClinicalMedicine 2023, DOI: 10.1016/j.eclinm.2023.101946), but Axcella shut down before it could get its planned 300-person follow-on study up and running.

The fate of AXA1125 may be to gather dust. Axcella’s former executives have moved on to other pursuits. Erstwhile chief medical officer Margaret Koziel, once a champion of AXA1125, says by email that she is “not up to date on current research on long COVID.” Staff at the University of Oxford, which ran the Phase 2a study, were not able to procure information about the planned Phase 2b/3 trial. A spokesperson for Flagship Pioneering, the venture firm that founded Axcella in 2011, declined to comment to C&EN.

Other firms have met similar ends. Ampio Pharmaceuticals dissolved in August after completing only a Phase 1 study to evaluate an inhaled medication called Ampion in people with long COVID who have breathing issues. Biotech firm SolAeroMed shut down before even starting a trial of its bronchodilating medicine for people with long COVID. “Unfortunately we were unable to attract funding to support our clinical work for COVID,” CEO John Dennis says by email.

Another biotech company, Aerium Therapeutics, did manage to get just enough of its monoclonal antibody AER002 manufactured and in the hands of researchers at the University of California, San Francisco, before it ended operations. The researchers are now testing AER002 in a Phase 2 trial with people with long COVID. Michael Peluso, an infectious disease clinician and researcher at UCSF and principal investigator of the trial, says that while AER002 may not advance without a company behind it, the study could be valuable for validating long COVID’s mechanisms of disease and providing a proof of concept for monoclonal antibody treatment more generally.

“[Aerium] put a lot of effort into making sure that the study would not be impacted,” Peluso says. “Regardless of the results of this study, doing a follow-up study now that we’ve kind of learned the mechanics of it with modern monoclonals would be really, really interesting.”

‘A squandered opportunity’ In 2022, the NIH’s National Institute of Allergy and Infectious Diseases (NIAID) put about $577 million toward nine research centers that would discover and develop antivirals for various pathogens. Called the Antiviral Drug Discovery (AViDD) Centers for Pathogens of Pandemic Concern, the centers were initially imagined as 5-year projects, enough time to ready multiple candidates for preclinical development. The NIH allocated money for the first 3 years and promised more funds to come later.

The prospect excited John Chodera, a computational chemist at the Memorial Sloan Kettering Cancer Center and a principal investigator at an AViDD center called the AI-Driven Structure-Enabled Antiviral Platform. Chodera figured that if his team were able to develop a potent antiviral for SARS-CoV-2, it could potentially be used to treat long COVID as well. A predominant theory is that reservoirs of hidden virus in the body cause ongoing symptoms.

But Chodera says NIAID told him and other AViDD investigators that establishing long COVID models was out of scope. And last year, Congress clawed back unspent COVID-19 pandemic relief funds, including the pool of money intended for the AViDD centers’ last 2 years. Lawmakers were supposed to come through with additional funding, Chodera says, but it never materialized. All nine AViDD centers will run out of money come May 2025.

“When we do start to understand what the molecular targets for long COVID are going to be, it’d be very easy to pivot and train our fire on those targets,” says Chanda from Scripps’s AViDD center. “The problem is that it took us probably 2 years to get everything up and going. If you cut the funding after 3 years, we basically have to dismantle it. We don’t have an opportunity to say, ‘Hey, look, this is what we’ve done. We can now take this and train our fire on X, Y, and Z.’ ”

Researchers at multiple AViDD centers confirm that the NIH has offered a 1-year, no-cost extension, but it doesn’t come with additional funds. They now find themselves in the same position as many academic labs: seeking grant money to keep their projects going.

Worse, they say, is that applying for other grants will likely mean splitting up research teams, thus undoing the network effect that these centers were supposed to provide.

“Now what we’ve got is a bunch of half bridges with nowhere to fund the continuation of that work,” says Nathaniel Moorman, cofounder and scientific adviser of the Rapidly Emerging Antiviral Drug Development Initiative, which houses an AViDD center at the University of North Carolina at Chapel Hill.

“This was a squandered opportunity, not just for pandemic preparedness but to tackle these unmet needs that are being neglected by biotech and pharma,” Chanda says.

Viral persistence Ann Kwong has been here before. The virologist was among the first industry scientists trying to develop antivirals for hepatitis C virus (HCV) back in the 1990s. Kwong led an antiviral discovery team at the Schering-Plough Research Institute for 6 years. In 1997, Vertex Pharmaceuticals recruited her to lead its new virology group.

Kwong and her team at Vertex developed a number of antivirals for HCV, HIV, and influenza viruses; one was the HCV protease inhibitor telaprevir. She recalls that a major challenge for the HCV antivirals was that scientists didn’t know where in the body the virus was hiding. Kwong says she had to fight to develop an antiviral that targeted the liver since it hadn’t yet been confirmed that HCV primarily resides there. People with chronic hepatitis C would in many cases eventually develop liver failure or cancer, but they presented with other issues too, like brain fog, fatigue, and inflammation.

She sees the same dynamic playing out in long COVID.

“This reminds me of HIV days and HCV days,” Kwong says. “This idea that pharma doesn’t want to work on this because we don’t know things about SARS-CoV-2 and long COVID is bullshit.”

Since January, Kwong has been cooking up something new. She’s approaching long COVID the way she did chronic hepatitis C: treating it as a chronic infection, through a start-up called Persistence Bio. Persistence is still in stealth; its name reflects its mission to create antivirals that can reach hidden reservoirs of persistent SARS-CoV-2, which many researchers believe to be a cause of long COVID.

“Long COVID is really interesting because there’s so many different symptoms,” Kwong says. “As a virologist, I am not surprised, because it’s an amazing virus. It infects every tissue in your body. . . . All the autopsy studies show that it’s in your brain. It’s in your gut. It’s in your lungs. It’s in your heart. To me, all the different symptoms are indicative of where the virus has gone when it infected you.”

Kwong has experienced some of these symptoms firsthand. She contracted COVID-19 while flying home to Massachusetts from Germany in 2020. For about a year afterward, she’d get caught off guard by sudden bouts of fatigue, bending over to catch her breath as she walked around the horse farm where she lives, her legs aching. Those symptoms went away with time and luck, but another round of symptoms roared to life this spring, including what Kwong describes as “partial blackouts.”

Kwong hasn’t been formally diagnosed with long COVID, but she says she “strongly suspects” she has it. Others among Persistence’s team of about 25 also have the condition.

“Long COVID patients have been involved with the founding of our company, and we work closely with them and know how awful the condition can be,” Kwong says. “It is a big motivator for our team.”

Persistence is in the process of fundraising. Kwong says she’s in conversations with private investors, but she and her cofounders are hoping to get public funding too.

On Sept. 23, the NIH is convening a 3-day workshop to review what RECOVER has accomplished and plan the next phase of the initiative. Crucially, that phase will include additional clinical trials. RECOVER’s $1.7 billion in funding includes a recent award of $515 million over the next 4 years. It’s not out of the question that this time, industry players might be invited to the table. Tonix Pharmaceuticals’ Lederman and Aim ImmunoTech’s McAleer will both speak during the workshop.

The US Senate Committee on Appropriations explicitly directed the NIH during an Aug. 1 meeting to prioritize research to understand, diagnose, and treat long COVID. It also recommended that Congress put $1.5 billion toward the Advanced Research Projects Agency for Health (ARPA-H), which often partners with industry players. The committee instructed ARPA-H to invest in “high-risk, high-reward research . . . focused on drug trials, development of biomarkers, and research that includes long COVID associated conditions.” Also last month, Sen. Bernie Sanders (I-VT) introduced the Long COVID Research Moonshot Act, which would give the NIH $1 billion a year for a decade to treat and monitor patients.

It’s these kinds of mechanisms that might make a difference for long COVID drug development.

“What I’ve seen a lot is pharma being hesitant to get involved,” says Lisa McCorkell, a cofounder of the PLRC and a coauthor of the recent long COVID review. “Maybe they’ll invest if NIH also matches their investment or something like that. Having those public-private partnerships is really, at this stage, what will propel us forward.”

#mask up #covid #pandemic #wear a mask #covid 19 #public health #coronavirus #sars cov 2 #still coviding #wear a respirator #long covid #covid conscious #covid is not over #wear a fucking mask

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mostlysignssomeportents · 1 year ago

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Uncle Sam paid to develop a cancer drug and now one guy will get to charge whatever he wants for it

Today (Oct 19), I'm in Charleston, WV to give the 41st annual McCreight Lecture in the Humanities. Tomorrow (Oct 20), I'm at Charleston's Taylor Books from 12h-14h.

The argument for pharma patents: making new medicines is expensive, and medicines are how we save ourselves from cancer and other diseases. Therefore, we will award government-backed monopolies – patents – to pharma companies so they will have an incentive to invest their shareholders' capital in research.

There's plenty wrong with this argument. For one thing, pharma companies use their monopoly winnings to sell drugs, not invent drugs. For every dollar pharma spends on research, it spends three dollars on marketing:

https://www.bu.edu/sph/files/2015/05/Pharmaceutical-Marketing-and-Research-Spending-APHA-21-Oct-01.pdf

And that "R&D" isn't what you're thinking of, either. Most R&D spending goes to "evergreening" – coming up with minor variations on existing drugs in a bid to extend those patents for years or decades:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680578/

Evergreening got a lot of attention recently when John Green rained down righteous fire upon Johnson & Johnson for their sneaky tricks to prevent poor people from accessing affordable TB meds, prompting this excellent explainer from the Arm and A Leg Podcast:

https://armandalegshow.com/episode/john-green-part-1/

Another thing those monopoly profits are useful for: "pay for delay," where pharma companies bribe generic manufacturers not to make cheap versions of drugs whose patents have expired. Sure, it's illegal, but that doesn't stop 'em:

https://www.ftc.gov/news-events/topics/competition-enforcement/pay-delay

But it's their money, right? If they want to spend it on bribes or evergreening or marketing, at least some of that money is going into drugs that'll keep you and the people you love from enduring unimaginable pain or dying slowly and hard. Surely that warrants a patent.

Let's say it does. But what about when a pharma company gets a patent on a life-saving drug that the public paid to develop, test and refine? Publicly funded work is presumptively in the public domain, from NASA R&D to the photos that park rangers shoot of our national parks. The public pays to produce this work, so it should belong to the public, right?

That was the deal – until Congress passed the Bayh-Dole Act in 1980. Under Bayh-Dole, government-funded inventions are given away – to for-profit corporations, who get to charge us whatever they want to access the things we paid to make. The basis for this is a racist hoax called "The Tragedy Of the Commons," written by the eugenicist white supremacist Garrett Hardin and published by Science in 1968:

https://memex.craphound.com/2019/10/01/the-tragedy-of-the-commons-how-ecofascism-was-smuggled-into-mainstream-thought/

Hardin invented an imaginary history in which "commons" – things owned and shared by a community – are inevitably overrun by selfish assholes, a fact that prompts nice people to also overrun these commons, so as to get some value out of them before they are gobbled up by people who read Garrett Hardin essays.

Hardin asserted this as a historical fact, but he cited no instances in which it happened. But when the Nobel-winning Elinor Ostrom actually went and looked at how commons are managed, she found that they are robust and stable over long time periods, and are a supremely efficient way of managing resources:

https://pluralistic.net/2023/05/04/analytical-democratic-theory/#epistocratic-delusions

The reason Hardin invented an imaginary history of tragic commons was to justify enclosure: moving things that the public owned and used freely into private ownership. Or, to put it more bluntly, Hardin invented a pseudoscientific justification for giving away parks, roads and schools to rich people and letting them charge us to use them.

To arrive at this fantasy, Hardin deployed one of the most important analytical tools of modern economics: introspection. As Ely Devons put it: "If economists wished to study the horse, they wouldn’t go and look at horses. They’d sit in their studies and say to themselves, ‘What would I do if I were a horse?’"

https://pluralistic.net/2022/10/27/economism/#what-would-i-do-if-i-were-a-horse

Hardin's hoax swept from the fringes to the center and became received wisdom – so much so that by 1980, Senators Birch Bayh and Bob Dole were able to pass a law that gave away publicly funded medicine to private firms, because otherwise these inventions would be "overgrazed" by greedy people, denying the public access to livesaving drugs.

On September 21, the NIH quietly published an announcement of one of these pharmaceutical transfers, buried in a list of 31 patent assignments in the Federal Register:

https://public-inspection.federalregister.gov/2023-20487.pdf

The transfer in question is a patent for using T-cell receptors (TCRs) to treat solid tumors from HPV, one of the only patents for treating solid tumors with TCRs. The beneficiary of this transfer is Scarlet TCR, a Delaware company with no website or SEC filings and ownership shrouded in mystery:

https://www.bizapedia.com/de/scarlet-tcr-inc.html

One person who pays attention to this sort of thing is James Love, co-founder of Knowledge Ecology International, a nonprofit that has worked for decades for access to medicines. Love sleuthed out at least one person behind Scarlet TCR: Christian Hinrichs, a researcher at Rutgers who used to work at the NIH's National Cancer Institute:

https://www.nih.gov/research-training/lasker-clinical-research-scholars/tenured-former-scholars

Love presumes Hinrichs is the owner of Scarlet TCR, but neither the NIH nor Scarlet TCR nor Hinrichs will confirm it. Hinrichs was one of the publicly-funded researchers who worked on the new TCR therapy, for which he received a salary.

This new drug was paid for out of the public purse. The basic R&D – salaries for Hinrichs and his collaborators, as well as funding for their facilities – came out of NIH grants. So did the funding for the initial Phase I trial, and the ongoing large Phase II trial.

As David Dayen writes in The American Prospect, the proposed patent transfer will make Hinrichs a very wealthy man (Love calls it "generational wealth"):

https://prospect.org/health/2023-10-18-nih-how-to-become-billionaire-program/

This wealth will come by charging us – the public – to access a drug that we paid to produce. The public took all the risks to develop this drug, and Hinrichs stands to become a billionaire by reaping the rewards – rewards that will come by extracting fortunes from terrified people who don't want to die from tumors that are eating them alive.

The transfer of this patent is indefensible. The government isn't even waiting until the Phase II trials are complete to hand over our commonly owned science.

But there's still time. The NIH is about to get a new director, Monica Bertagnolli – Hinrichs's former boss – who will need to go before the Senate Health, Education, Labor and Pensions Committee for confirmation. Love is hoping that the confirmation hearing will present an opportunity to question Bertagnolli about the transfer – specifically, why the drug isn't being nonexclusively licensed to lots of drug companies who will have to compete to sell the cheapest possible version.

If you'd like an essay-formatted version of this post to read or share, here's a link to it on pluralistic.net, my surveillance-free, ad-free, tracker-free blog:

https://pluralistic.net/2023/10/19/solid-tumors/#t-cell-receptors

My next novel is The Lost Cause, a hopeful novel of the climate emergency. Amazon won't sell the audiobook, so I made my own and I'm pre-selling it on Kickstarter!

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