#bioscience

[mau-mao]

Vitiligo vs Fever Coat vs Smoke Color

Some may confuse these three things because of their similar appearances.

This is vitiligo ↑↑↑

They are not born with this condition (if they are, it may be a case of chimerism), it shows up as they age. The white/unpigmented spots will grow and develop all over. Don't worry, it isn't harmful. It's just like human vitiligo!

This is fever coat ↑↑↑

It's a rare condition in which the mama cat undergoes severe stress or an illness that causes a spike in body temperature during pregnancy. Prior to birth, the pigmentation of a kitten's coat is very sensitive to heat. When the kittens are born, you will notice white/frosted tips of fur along the body. Fortunately, this has no negative effect on them. Their original coat color is still written in their DNA and may take from 4 months up to a year to present itself.

This is a smoke pattern ↑↑↑

These cats have black fur with white roots. They are also born this way and keep this marvelous color. For longhair smokes, their mane and any other section where the fur is longer will look white.

[jonreytrevino]

NES - Bio Lab

pixel_dailies : laboratory : restriction - 20px tiles or less : 11/16/23

[gotharachne]

Some pictures and samples from the geology trip I went to yesterday

The little waves in the first picture are approximately 280 million years old from a glacial lake (the third picture shows the walls of the lake)

[dr-southernerd]

Laying on my stomach, kicking my feet in the air and singing while writing in my lab notebook

[guardianmonae32]

Check out my recent video where I am sharing my Tips on Applying to Graduate School! 🎓

[l-m-rain]

Me going from migraine that makes me want to die, to applying to 2 different free university courses, playing 3 games at the same time, watching at the very least 3 shows and interacting with 11 different fandoms.

And all because of coffee, even tho it doesn't change the fact that I have no energy for any of those things

[inventforgood]

My idea is that cDNA libraries of the mRNA from humans of different ages, eg 1 year, 5 years, 10 years, 15 years, 22 years, 30 years, 40 years, 55 years, 70 years and 85 years (but practically it would be necessary to just take the samples that became available!) could be constructed or acquired. They could also be acquired from specific “aging critical” tissues/organs eg endothelium, cardiac, pulmonary, kidney, brain etc. The cDNA libraries could be compared by constructing microarrays (that is my dated knowledge but today it could probably be done computationally).

What would that give us? By the differences in the transcriptome between the different age cohorts it would show the difference between aged tissues and young tissues.

Of course, how these differences arose is AS a result of the epigenetic processes, but the differences themselves ARE the results of the epigenetic processes and (in some way which I am not able to imagine right now) may lead to approaches to discover more about the epigenetic processes themselves, which is your interest. Please forgive me if I am telling you things that are already second nature to you, but there is more to my proposal which is in fact quite simple really although very broad in scope and ambitious in outcome.

The differences mentioned above would be either the absence of specific mRNA in older tissues that is present in younger tissues, or vice versa, or quantitative differences in levels of mRNA.

That then gives a series of mRNA targets to investigate, both upstream, in terms of regulation of transcription such as transcription factors and silencing, and downstream in terms of identifying and characterising the protein product of the mRNA, its structure, binding sites, effects etc. That as you said before is quite a considerable body of work and would require many teams of researchers.

As far as intervention to promote health is concerned, discovering the epigenetic processes which cause the changes would be one pathway to treatments; other pathways could be pharmaceutical, perhaps based on transcription factors, and gene-therapy based approaches.

I think that the approach I have outlined is slightly different to that of the Yamanaka factors, which reset some cells to pluripotent stem cells, as my approach is intended to make differentiated cells youthful but still basically differentiated, as in the functioning young

adult.

I have heard of a researcher called Jaoa de Magalhaes who was said to be doing something like what I suggest (and he has now moved to Birmingham University in Britain) but I do not see mention of it on his website, he talks about long lived species, another interesting approach. An academic in Cambridge told me that she had heard of something like this that I propose being done in Singapore, but did not know the name of the researcher. So, although this approach is not truly novel, I believe it is still new ground.

[justmisstaker]

MY FAVES MY FAVES

Fuckin love leaf sheep

Little dudes photosynthesise, like, they took one look at human taxonomic practices and said "lol, but watch this though"

You eat the sun ya little goobers, you're adorable and can do no wrong, I'll bite anyone who says otherwise

[octanexlabsin]

Shaping the Future of Chemical Synthesis: Dedicated to Pharma, Agro, Fine and Specialty Chemicals, CRO, and CDMO sectors, we deliver advanced synthesis solutions with a strong emphasis on quality. Through custom development and CRAMS, we collaborate with global clients to meet the highest standards. Our purpose is to improve life quality through outstanding research, manufacturing, and marketing efforts.

[mau-mao]

How Tortoiseshell Cats Get Their Patterns

Ever wonder why every tortie cats aren't just 50% black and 50% red?

The X chromosome in cats determines color (orange or black).

There is a process named lyonization, or X-inactivation, that occurs in female cats. When the kitty embryo is growing one of the X chromosomes in each cell will randomly inactivate. The active X will be expressed.

B = orange b = black If the Xᴮ inactivates the cell will express black. If the Xᵇ inactivates the cell will express orange.

[meridianbioscience]

Meridian Bioscience supports healthcare providers and researchers worldwide in advancing patient care.

[megamijadeheart]

That's actually why I stopped studying biology and switched to art, because I knew I would end up in prison due to ethics violations lol

[amrtechinsights]

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[impact-newswire]

Axol Bioscience acquires Phenocell to advance human disease models

Acquisition expands Axol’s iPSC-derived cell models and service offering to include ophthalmology and dermatology CAMBRIDGE / EDINBURGH, UK, and GRASSE, FRANCE, October 2024: Axol Bioscience Ltd. (Axol), a leading induced pluripotent stem cell (iPSC) technology provider for drug discovery, today announced it has fully acquired Phenocell SAS, a pioneer in iPSC-based products and bioassays for…

[filosofablogger]

The Good, The Bad, and The Ugly -- Planet Earth

I’m just a wee bit tired of talking politics, y’know?  Of course politics enters into every other topic, whether loudly or silently, but there are other things to talk about … like, um … well, the environment and climate change, for one!  An article that hit my inbox this morning triggered the thought, and so today I have some good news … and of course, some bad news too. The good … While some…

[deepgoraniya]

Strengths and weaknesses

I have never focused on this topic about myself, it was kind of hard to find my own weaknesses as I have always looked at my strengths. however, when I thanked about it, I realized a lot of things.

Strengths: -

Adaptability to adjust to new situations and challenges

problem solving or critical thinking

resilience, stay calm during stressful situations or problem solving

communication skills.

reliability

self-motivated

work ethics.

Weaknesses: -

perfectionism, sometimes I try to be more perfect which in return steal my lot of time.

Time management is one the major weaknesses.

Overcommitting, for me it is hard to say No, which leads to a lot of responsibilities.

Overthinking

Emotional Sensitivity

Hesitation to ask for assistance or help when needed.

Work Life balance, this has been always a major weakness of mine.