#NIGMS

[reportwire]

CHOP Researchers Identify Molecules that Optimize Immune Presentation of Antigens across the Human Population

Newswise — Philadelphia, February 24, 2023—Researchers at Children’s Hospital of Philadelphia (CHOP) have identified variants of a chaperone molecule that optimizes the binding and presentation of foreign antigens across the human population, which could open the door to numerous applications where robust presentation to the immune system is important, including cell therapy and immunization. The…

[wibble-wobbegong]

richard henry creel is really such a character. Such a character.

so, quick summary, in one of the newspaper articles there’s a mention of someone names richard brenner

found by @aemiron-main

richard brenner is listed as the head of the Narcotic Enforcement Division from 1954-1971

richard henry creel is the son of virginia fackle creel and henry clay creel. im sure the connection is obvious

anyway, when we look into who this richard henry creel guy was, we learn that he was the assistant surgeon general of the U.S. public health service, and to become this head he’d have to have had specialized training or significant experience in public health. so, this guy was heavily involved in this stuff, though his exact service starts in 1921 but the end is never specified

under the PHS, the, “The Division of Venereal Diseases was established in 1918, and the Narcotics Division in 1929 (it eventually became the National Institute of Mental Health).”

now, richard henry creel was born in 1878 — he would’ve been in his 50’s by the time the narcotics division was actually created

1955 - “The National Microbiological Institute became the National Institute of Allergy and Infectious Diseases (NIAID) by order of the Surgeon General on December 29. The Biologics Control Laboratory was detached from the institute and expanded to division status within NIH.”

1957 - “The Center for Aging Research was established November 27 as the focal center for NIH extramural activities in gerontology.”

1958 - “On July 16 the Division of General Medical Sciences was established by order of the Surgeon General, extending research into noncategorical areas covered until that time by the Division of Research Grants. The Center for Aging Research was transferred from the National Heart Institute to the Division of General Medical Sciences on November 4.”

1962 - “Five acres of land for a Gerontology Research Center were donated by the City of Baltimore in December.”

1963 - “The National Institute of Child Health and Human Development and the National Institute of General Medical Sciences were established on January 30. The Center for Research in Child Health and the Center for Research in Aging (established in 1956) were transferred from NIGMS to NICHD.”

1967 - “The National Institute of Mental Health [narcotics division] was separated from NIH and raised to bureau status in PHS by a reorganization that became effective January 1.“

1971 - “The White House Conference on Aging recommended creating a separate National Institute on Aging on December 2.”

source

now that’s a lot of words and moving and bullshit, so here’s the most important stuff to know.

richard henry creel was appointed assistant general surgeon in 1921, and 8 years later the Narcotics Division was formed. the surgeon general he was serving served from 1920 to 1936 — it isn’t much of a reach to say he was probably involved in the creation of this division

now, richard brenner was supposedly the head of the Narcotics Enforcement Division from 1954 to 1971. during that time, the narcotics division was brought up to bureau status, putting it at rank with programs like the FBI and an entire institute dedicated to researching the effects of aging were created, merging aging research with child health research

all of this stuff has roots in the PHS, and the PHS’ biggest start up was chemical research. all of this gets rooted back to chemical research

so, when we look at it, we can see that the same year the institute on aging was created, richard brenner was resigned and richard creel died. this was the year that all the main kids were born, most importantly el and will

i’d also like to point out the center of aging stuff began about two years before henry was taken by brenner. that would be when henry was 10, and i believe that that was the year henry moved to hawkins (trust in @laozuspo) and it was only a year after richard brenner had gotten involved with the narcotics division

what could this all be pointing to? well, both em and james have been feeding me stuff about henry’s regeneration abilities. more importantly, how they resemble cancer. what i didn’t include in the info from 1955 is that the first ever cancer chemotherapy center was established — the same year the Biologics Control Laboratory was given its own division. the BCL explored viral diseases and produced vaccines. the word ‘sick’ in the show has prominent value on a deeper level, as stav has explained, but if we take it more surface level…

ALL i’m saying is that a ton of this stuff lines up. i don’t have a clear answer as to what exactly it means or how we got from A to B for sure, but it seems a lot like this richard character was interested in henry’s cancer-like regeneration abilities. possibly even in an attempt to prevent the process of aging. maybe, just maybe, richard brenner, richard henry creel, and martin brenner aren’t all that different *wink wink*

[sejarahku]

'Pavillon Trocadero' and the pavilions of the NIGM and Nestlé at the Colonial Exhibition in Semarang

[prayer-in-time]

Prayer time in Drib Nigm

In Drib Nigm, prayer time is an integral part of the community's daily rhythm, weaving spirituality into the tapestry of life. As the sun's first rays kiss the horizon, the call to prayer resonates through the air, a gentle reminder of devotion and connection with the divine. Families and individuals gather in mosques, homes, and open spaces, their hearts united in reverence and supplication.

The atmosphere during prayer time in Drib Nigm is serene, filled with the melodious recitation of sacred verses and the fragrance of incense. It's a moment of introspection and humility, where worldly worries fade into insignificance before the majesty of God.

People from diverse backgrounds come together, their differences melting away in the shared act of worship. The rhythmic movements of prayer, the whispered invocations, and the collective sense of devotion create a profound sense of unity and peace.

Prayer time in Drib Nigm isn't just a ritual; it's a spiritual journey, a time to seek guidance, solace, and blessings. It's a daily reminder of the sacredness of life and the importance of nurturing the soul amidst life's hustle and bustle. visit link https://prayerintime.com/prayer-times-in-drib-nigm/

[rnomics]

Fluent BioSciences awarded NIH SBIR grant to r#evolutionize single cell analysis

Fluent BioSciences, a cutting edge life sciences company leading the charge in r#evolutionizing single cell analysis through simple, cost-effective, and highly scalable single-cell #RNA sequencing solutions is thrilled to announce the award of an NIH Small Business Innovation Research (SBIR) Phase II grant, funded by the National Institute of General Medical Sciences (NIGMS, 1 R44 GM137648). ... https://www.rna-seqblog.com/fluent-biosciences-awarded-nih-sbir-grant-to-revolutionize-single-cell-analysis/?utm_source=dlvr.it&utm_medium=tumblr

[evoldir]

Fwd: Postdoc: IndianaU.SexChromosomeGenomics

Begin forwarded message: > From: evoldir@evol.biology.mcmaster.ca > Subject: Postdoc: IndianaU.SexChromosomeGenomics > Date: 6 September 2023 at 08:03:54 BST > To: rdmpage@gmail.com > > > A postdoc position is available in the Bracewell Lab at Indiana > University, Bloomington. We are looking for a colleague to join an NIH > NIGMS-funded project looking at chromosome/genome evolution at multiple > evolutionary timescales in beetles and flies. We are particularly > interested in understanding chromosome fusion/fission and changes in > centromere position and the genomic changes that follow. Depending on the > applicants background, directions could include large-scale comparative > analyses in Drosophila to population genetics/genomics in a species of > bark beetle with variation in neo-sex chromosomes. With this position, > there is room to develop projects based on personal interest and research > strengths under the larger umbrella of the project. Please reach out > for more details on the projects and scope of research. The College of > Arts and Sciences is committed to building and supporting a diverse, > inclusive, and equitable community of students and scholars. Indiana > University is an equal employment and affirmative action employer > and a provider of ADA services. All qualified applicants will receive > consideration for employment based on individual qualifications. Indiana > University prohibits discrimination based on age, ethnicity, color, > race, religion, sex, sexual orientation, gender identity or expression, > genetic information, marital status, national origin, disability status > or protected veteran status. > > For more information about the Bracewell lab or the Biology Department, > visit Home (ryanbracewell.com) > and Department of Biology: Indiana University > Bloomington. A Ph.D. in Biology or > a related field with previous research experience in evolutionary > genetics, genomics, or bioinformatics is required. The ideal candidate > will have some programming experience using both R and python and > familiarity with large-scale genomic analyses on high performance > computing clusters. Excellent communication skills and the ability > to work independently as well as part of a team are expected. Salary > will be commensurate with experience and will be highly competitive > for the right person. Best consideration date is Sept 30th, 2023, > but position will remain open until filled. The expected start date > is negotiable but could be as early as 11/1/2023. 100% remote work > is not available. Please submit a cover letter describing interest > and previous experience, a curriculum vitae, and the names of at > least three references (including email addresses and phone numbers) > to https://ift.tt/5qVRYgc. For questions about > the position and additional details about the research, please contact > Dr. Ryan Bracewell (rbracewe@iu.edu). The Bracewell Lab is located on the > beautiful Indiana University campus. The city of Bloomington is in the > rolling hills of southern Indiana and provides ample outdoor recreation > in an affordable mid-sized city. > > > > "Bracewell, Ryan Russell"

[realjaysumlin]

Cells and our health. Your life depends on them.

[lboogie1906]

Geraldine Pittman Woods (January 29, 1921 – December 27, 1999) was a science administrator. She is known for her lifelong dedication to community service and for establishing programs that promote minorities in STEM fields, scientific research, and basic research. She was the 13th National President of Delta Sigma Theta Sorority. She was born in West Palm Beach to Susie and Oscar Pittman. She graduated from high school and attended Talladega College and transferred to Howard University. She excelled in biology and other science classes. She attended a Radcliffe College and Harvard University partnership program to earn an MS and a Ph.D. in neuro-embryology. She was elected into Phi Beta Kappa. She has earned numerous awards for her dedication to community service and minority rights, including the Mary Church Terrell Award of Delta Sigma Theta and the Scroll of Merit of the National Medical Association, the Howard University Achievement Award, and a Distinguished Leadership Achievement Award from the National Association for Equal Opportunity in Higher Education. The sixth annual NIGMS Minority Biomedical Support symposium held at the Atlanta University Center was dedicated to her. The Federal City Chapter of Delta Sigma Theta Sorority, Inc. recognized her contributions to the sorority by establishing the Geraldine P. Woods Sciences Award. At the Annual Biomedical Research Conference for Minority Students, NIGMS unveiled the Geraldine Woods Award because of her pivotal role in the development of the MBRS and MARC. A fellowship in biology at Howard University and one in chemistry at Atlanta University have both been established in her name. She has earned honorary degrees at Benedict College, Talladega College, Fisk University, Bennett College, Meharry Medical College, and Howard University. She married Robert Woods, a dentistry student at Meharry Medical College. After he graduated from dentistry school they moved to Los Angeles where she put her career on hold to raise their three children. #africanhistory365 #africanexcellence #deltasigmatheta https://www.instagram.com/p/CoAWM3Or5gs/?igshid=NGJjMDIxMWI=

[meditech-insights]

Global Sepsis Diagnostics Market valued at ~$510 million in 2021 and is anticipated to grow at a healthy CAGR of 9% by 2026

Sepsis is a life-threatening medical emergency. It is body's reaction to an infection may cause tissue damage, a systemic inflammatory response, and ultimately organ dysfunction and/or failure.

According to the WHO, sepsis affects around 49 million people globally each year. Early diagnosis of sepsis is critical for patient outcomes. Sepsis has no specific symptom or indication that is directly associated with the disease, therefore diagnosing it might be difficult.

The GlobalSepsis Diagnostics Marketvalued at ~$510 million (2021) is set to witness a healthy growth rate of 9% in the next 5 years. Increasing cases of sepsis and hospital-acquired infections, the development of quick diagnostic tests and point-of-care techniques, and favorable initiatives and funding for sepsis-related research are some of the major drivers driving the global sepsis diagnostics market.

However, limited awareness about sepsis is likely to hamper the growth of the sepsis diagnostics market.

Development of Rapid Diagnostic Tests/Point-of-Care Techniques Set to Drive the Sepsis Diagnostics Market

Currently, clinicians possess limited technology needed to conduct multiplexed and fully quantitative diagnostic tests at the point of care with high sensitivity. Numerous research universities and product manufacturers are developing innovative rapid diagnostic tests/point-of-care techniques in response to the demand for quick diagnostic tests.

For instance,

Researchers at the University of Strathclyde have developed an innovative, low cost test for early diagnosis of sepsis. The experimental device analyzes patient's blood and provides results in just 2.5 minutes compared to current testing methods for sepsis which takes up to 72 hours.

“With sepsis, timing is the key. Advancements in diagnostic speed, range, and accuracy are critical for addressing the continued rise in sepsis cases and deaths. Advent of new rapid diagnostic tests for sepsis can save thousands of lives.”- Senior Director, Leading In-Vitro Diagnostics Manufacturer, United States

Explore Premium Report on Sepsis Diagnostics Market @ https://meditechinsights.com/sepsis-diagnostics-market/

Favorable Initiatives & Funding for Sepsis Research

(NIGMS) intends to use the NIH SBIR/STTR program to support preclinical and clinical sepsis studies to create better diagnostic methods and therapies in an attempt to shape the future of sepsis research.

Diagnostics companies are also continuously securing funding to develop rapid sepsis diagnostic tests.

For instance,

In February 2022, CytoVal, a medical diagnostics company secured additional funding from Biomedical Advanced Research and Development Authority (BARDA) to help advance the company’s 10-minute IntelliSep™ sepsis risk stratification test towards commercial launch

In June 2021, HelixBind secured $3 million National Institutes of Health (NIH) grant to support testing of its rapid diagnostic platform for invasive infections associated with sepsis

Competitive Landscape Analysis of Sepsis Diagnostics Market

The global sepsis diagnostics market is marked by presence of both established players such as bioMérieux, Becton, Dickinson and Company, Thermo Fisher Scientific, Danaher Corporation and innovative firms such as Seegene Inc., Axis-Shield Diagnostics, Immunexpress, and others.

For More Detailed Insights, Contact Us @ https://meditechinsights.com/contact-us/

About Medi-Tech Insights

Medi-Tech Insights is a healthcare-focused business research & insights firm. Our clients include Fortune 500 companies, blue-chip investors & hyper-growth start-ups. We have completed 100+ projects in Digital Health, Healthcare IT, Medical Technology, Medical Devices & Pharma Services.

Contact:

Ruta Halde

Associate, Medi-Tech Insights

+32 498 86 80 79

info@meditechinsights.com

[frontal-cortex]

Mouse retina by NIH Image Gallery Via Flickr: What looks like the gossamer wings of a butterfly is actually the retina of a mouse, delicately snipped to lay flat and sparkling with fluorescent molecules. The image is from a research project investigating the promise of gene therapy for glaucoma. It was created at an NIGMS-funded advanced microscopy facility that develops technology for imaging across many scales, from whole organisms to cells to individual molecules. The ability to obtain high-resolution imaging of tissue as large as whole mouse retinas was made possible by a technique called large-scale mosaic confocal microscopy, which was pioneered by the NIGMS-funded National Center for Microscopy and Imaging Research. The technique is similar to Google Earth in that it computationally stitches together many small, high-resolution images. More details: images.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3697 Credit: Kenyoung Kim, Wonkyu Ju and Mark Ellisman, National Center for Microscopy and Imaging Research, University of California, San Diego NIH funding from: National Institute of General Medical Sciences (NIGMS)

[thesingleparentcounselor]

You may not be familiar with the #SDSU #NIH #NIGMS #MARC Scholars program but I am extremely proud of the work we do. Not only do I get to work with some really amazing colleagues and students (Dr. Cathie Atkins has successfully lead this program since day one) but I get to be part of this wonderful #STEM community at #SDSU and be a resource to students who will always hold a special place in my heart. Thank you NIH/NIGMS! Thank you SDSU! Thank you Cathie Atkins and Stanley Maloy! Here's to many, many more years....... #scholasticsupportsaturday #scholastic #academiclife #stemeducation #underrepresented #nobrokenhome https://www.instagram.com/p/CadHArFPPNN/?utm_medium=tumblr

[riddlersbrew]

trails around gotham

[historyatnih]

“Biologists view themselves as fortunate compared to a field like physics, where you can't do an experiment without a huge team of people and very expensive equipment. There was concern that biology would become like physics, dependent on these large accelerators and other kinds of gizmos and huge teams of people working together in order to get anything done. In some ways they were right. There still is lots of work for individual investigators coming up with their own ideas to pursue, but certainly many of the questions at the forefront now require multidisciplinary teams of people and significant equipment in order to do research.”  Dr. Elke Jordan, 2002

Jordan came to NIH in 1972, working at NCI and NIGMS.  In 1988, she became director of the Office of Human Genome Research, responsible for laying the foundation for the infrastructure of the Human Genome Project at NIH. In her oral history, she discusses James Watson, Genbank, patents, ethics, media hype, and much more.  Read it at

https://history.nih.gov/archives/downloads/ejordan.pdf

[thelegend9798]

Without 'work-life balance,' this protein may promote disease

Without ‘work-life balance,’ this protein may promote disease

Newswise — COLUMBUS, Ohio – A family of proteins that have a role in ensuring many types of cells move and maintain their shape may promote disease when they act like workaholics and disrupt the cellular environment, new research suggests. The study increases scientific understanding of plastins, whose job is to bind to and bundle other proteins that can be thought of as the bones and muscles of…

[crystal-net]

The Antidote - 2 (on Wattpad) https://www.wattpad.com/1170204271-the-antidote-2?utm_source=web&utm_medium=tumblr&utm_content=share_reading&wp_uname=LylaSali5&wp_originator=0Yf%2FGqhMiYhGIE2sbnt7oQn0cFFegYo8Lio%2BWcohg5RBqd825iDNh2Z7txYuAGkTbqzSjjm8wyvP9AGvJ8R3zksbeLCuedYB7F4yPELeh%2BlfB1Qk6kLdCRE234Z7qJqu La lune, le Soleil L'Obscurité, la Lumière Le Feu, l'Eau Mia, Namjoon Toutes ces choses bien qu'elles soient contraires ont toutes un point commun. Qu'est-ce ? "- tu veux un verre ?" Pourquoi bon sang avait-il accepté ? Pour son sourire innocent ? Pour ses courbes désireuses ? S'il n'avait pas accepté, que serait-il arrivé ? Je vous propose de venir le découvrir Nouveau chapitre tous les mercredis à 19h

[nctrnm]

#NowPlaying: " PREMIERE | Nigm - Ephemeral [La Forge] 2021" by 44,100Hz Social Club