#Motility Disorders

[burialrite]

Had the second worst medical procedure of my entire life today BUT i WAS told that it immediately turned up abnormal results AND apparently my insides did something that they've never seen happen before :D

[gauricmi]

Gastric Motility Disorder Drug:  New Treatments Emerging for Difficult Gastric Disorders

Understanding Gastric Motility Disorder Drug GMD are a group of conditions that affect the normal movement of contents through the stomach. The stomach acts as a holding chamber, churning and partially breaking down food before advancing it into the small intestine. In GMD, this process is disrupted leading to a variety of symptoms. Some common types of GMD include gastroparesis, dysfunctional dyspepsia, and nausea and vomiting of unknown cause. Gastroparesis, or delayed gastric emptying, occurs when the stomach takes too long to empty its contents. This allows food to linger and ferment in the stomach, causing discomfort. Symptoms of gastroparesis include vomiting, heartburn, bloating, and abdominal pain after eating. Dysfunctional dyspepsia is characterized by these same symptoms but normal gastric emptying. The exact cause is unknown. Nausea and vomiting of unknown cause involves episodes of nausea and vomiting without an identifiable trigger. All of these conditions can greatly impact quality of life. Current Treatment Limitations The current treatment paradigm for Gastric Motility Disorder Drug focuses on symptom management rather than addressing the underlying dysfunction. For gastroparesis, dietary changes such as smaller, more frequent low-fat meals are recommended, along with prokinetic drugs to stimulate gastric emptying. However, available prokinetics have important tolerability issues and limited efficacy. Metoclopramide is often used but can cause Parkinsonism-like side effects with long-term use. Domperidone is not approved in the U.S. due to cardiac concerns. For symptoms like nausea and vomiting, antiemetics are utilized, but they do not work for all patients and their effects are temporary. Other approaches used include antacids and proton pump inhibitors for reflux relief. While these measures provide some benefit, they do not correct the gastric dysmotility driving the ongoing symptoms. A large unmet need exists for new options that can more predictably and sustainably improve gastric function and resolution of symptoms for those suffering from these difficult disorders. Emerging Treatments Targeting Underlying Pathophysiology Researchers are pursuing novel mechanisms that could restore normal coordinated gastric contractions in order to enhance emptying. One approach involves enhancing vagal nerve stimulation, important for controlling gastric motility. Implantable neurostimulation devices are being studied to electrically activate the vagus nerve in a coordinated manner. Early data suggests increased antral contractions and symptom improvement compared to sham stimulation in gastroparesis patients. Further development is ongoing. Aside from neurostimulation, pharmacological agents targeting specific receptors involved in gastric motility are being investigated. One drug enhances the activity of motilin, a hormone critical for digestive muscle contractions. It is currently in Phase III testing for gastroparesis. By mimicking the natural process motilin triggers, this medication may have the potential to safely and effectively promote gastric emptying in a sustained manner. Another compound under study targets a bile acid receptor called TGR5. TGR5 activation leads to GLP-1 release which drives gastric emptying. Preliminary results show more rapid gastric emptying compared to placebo in healthy individuals. If successful in motility disorders, these novel mechanisms could change the fundamental treatment paradigm. Get More Insights On This Topic:  Gastric Motility Disorder Drug

[scientia-rex]

Because my most popular post is about weight loss and how it's a crock, I get a lot of questions about various things, including bariatric surgery--just posted the link to the post I did about that--but also Ozempic/Wegovy, the once-weekly injectable semaglutide medication that was developed for diabetes but was found to have independent benefits on weight loss.

I always said that weight loss was like Viagra: when a medication came along that actually worked, it would explode. We'd all hear about it. Fen-phen in the 90s worked, but it was bad for your heart. Stimulants, like meth, may cause weight loss, but they do it at the cost of heart health, and raise your likelihood of dying young. Over the counter weight loss supplements often contain illegal and unlisted thyroid hormone, which is also dangerous for the heart if taken in the absence of a real deficiency. Orlistat, or "Alli," works the same way as the Olestra chips Lays made in the 1990s--it shuts off your ability to digest fats, and the problem with that is that fats irritate the gut, so then you end up with fatty diarrhea and probably sharts. Plus Alli only leads to 8-10lbs of weight loss in the best case scenario, and most people are not willing to endure sharts for the sake of 8lbs.

And then came the GLP-1 agonists. GLP stands for glucagon-like peptide. Your body uses insulin to make cells uptake sugar. You can't just have free-floating sugar and use it, it has to go into the cells to be used. So if your body sucks at moving sugar into the cells, you end up with a bunch of glucose hanging out in places where it shouldn't be, depositing on small vessels, damaging nerves and your retinas and kidneys and everywhere else that has a whole lot of sensitive small blood vessels, like your brain.

Glucagon makes your liver break down stored sugars and release them. You can think of it as part of insulin's supporting cast. If your body needs sugar and you aren't eating it, you aren't going to die of hypoglycemia, unless you've got some rare genetic conditions--your liver is going to go, whoops, here you go! and cough it up.

But glucagon-like peptide doesn't act quite the same way. What glucagon-like peptide does is actually stimulating your body to release insulin. It inhibits glucagon secretion. It says, we're okay, we're full, we just ate, we don't need more glucagon right now.

This has been enough for many people to both improve blood sugar and cause weight loss. Some patients find they think about food less, which can be a blessing if you have an abnormally active hunger drive, or if you have or had an eating disorder.

However, every patient I've started on semaglutide in any form (Ozempic, Wegovy, or Rybelsus) has had nausea to start with, probably because it slows the rate of stomach emptying. And that nausea sometimes improves, and sometimes it doesn't. There's some reports out now of possible gastroparesis associated with it, which is where the stomach just stops contracting in a way that lets it empty normally into the small intestine. That may not sound like a big deal, but it's a lifelong ticket to abdominal pain and nausea and vomiting, and we are not good at treating it. We're talking Reglan, a sedating anti-nausea but pro-motility agent, which makes many of my patients too sleepy to function, or a gastric pacemaker, which is a relatively new surgery. You can also try a macrolide antibiotic, like erythromycin, but I have had almost no success in getting insurance to cover those and also they have their own significant side effects.

Rapid weight loss from any cause, whether illness, medication, or surgery, comes with problems. Your skin is not able to contract quickly. It probably will, over long periods of time, but "Ozempic face" and "Ozempic butt" are not what people who want to lose weight are looking for. Your vision of your ideal body does not include loose, excess skin.

The data are also pretty clear that you can't "kick start" weight loss with Ozempic and then maintain it with behavioral mechanisms. If you want to maintain the weight loss, you need to stay on the medication. A dose that is high enough to cause weight loss is significantly higher than the minimum dose where we see improvements in blood sugar, and with a higher dose comes higher risk of side effects.

I would wait on semaglutide. I would wait because it's been out for a couple of years now but with the current explosion in popularity we're going to see more nuanced data on side effects emerging. When you go from Phase III human trials to actual use in the world, you get thousands or millions more data points, and rare side effects that weren't seen in the small human trials become apparent. It's why I always say my favorite things for a drug to be are old, safe, and cheap.

I also suspect the oral form, Rybelsus, is going to get more popular and be refined in some way. It's currently prohibitively expensive--all of these are; we're talking 1200 or so bucks a month before insurance, and insurance coverage varies widely. I have patients who pay anything from zero to thirty to three hundred bucks a month for injectable semaglutide. I don't think I currently have anyone whose insurance covers Rybelsus who could also tolerate the nausea. My panel right now is about a thousand patients.

There are also other GLP-1 agonists. Victoza, a twice-daily injection, and Trulicity, and anything else that ends in "-aglutide". But those aren't as popular, despite being cheaper, and they aren't specifically approved for weight loss.

Mounjaro is a newer one, tirzepatide, that acts on two receptors rather than one. In addition to stimulating GLP-1 receptors, it also stimulates glucose-dependent insulinotropic polypeptide (GIP) receptors. It may work better; I'm not sure whether that's going to come with a concomitantly increased risk of side effects. It's still only approved for diabetes treatment, but I suspect that will change soon and I suspect we'll see a lot of cross-over in terms of using it to treat obesity.

I don't think these medications are going away. I also don't think they're right for everyone. They can reactivate medullary thyroid carcinoma; they can fuck up digestion; they may lead to decreased quality of life. So while there may be people who do well with them, it is okay if those people are not you. You do not owe being thin to anyone. You most certainly do not owe being thin to the extent that you should risk your health for it. Being thin makes navigating a deeply fat-hating world easier, in many ways, so I never blame anyone for wanting to be thin; I just want to emphasize that it is okay if you stay fat forever.

[cannabiscomrade]

It's Gastroparesis Awareness Month

Hi! I have gastroparesis and I'm an insufferable know-it-all so let's talk about it!

Gastroparesis, or a paralyzed stomach, is a condition that causes delayed gastric emptying.

This can cause a range of symptoms and complications:

nausea

vomiting

early satiety/fullness

upper gastric pain

heartburn

malabsorption

dehydration

malnutrition

Gastroparesis can be treated by a gastroenterologist, but often needs to be managed by a motility specialist due to a lot of misconceptions about the condition. Providers, especially in the emergency department, will commonly misdiagnose gastroparesis as cannabis-hyperemesis syndome, cyclic vomiting syndrome, gastritis, food poisoning, etc.

There are several commonly known causes of gastroparesis like vagus nerve damage from diabetes, injury to the stomach, and stomach surgery like hernia repair or bariatric surgery. There are also idiopathic cases with no known cause. Other causes of gastroparesis are:

Connective tissue disorders like HSD and EDS (commonly hEDS and cEDS)

Post-viral (like COVID, viral gastritis, mononucleosis/Epstein-Barr)

Restrictive eating disorders

Autoimmune diseases like Systemic sclerosis (scleroderma), Lupus, Hashimoto's

Central nervous system disorders

Gastroparesis also has common comorbidities with conditions like:

POTS and other forms of dysautonomia (POTS, EDS, and gastroparesis are a common triad of diagnoses)

MCAS

SMAS (which can also present with similar symptoms to GP)

Intestinal dysmotility and esophageal dysmotility disorders (known as global dysmotility)

PCOS with insulin resistance

Endometriosis

SIBO/SIFO

Chronic intestinal pseudo-obstruction

Migraines

Certain medications like Ozempic and other drugs in that class act on the digestive system to delay gastric emptying, which has caused people to be diagnosed with gastroparesis. Some people report that their cases have not gone away since stopping the medication, others report feeling better after stopping. Other drugs like opiates and narcotics can cause delayed gastric and intestinal motility as well, but these are commonly known side effects of those painkiller classes.

Gastroparesis is classed based on severity and graded based on how you respond to treatment.

Severity of delay ranges from mild to very severe, and this is based on your actual stomach retention calculated at 4 hours into a gastric emptying study.

The grading scale ranges from one to three, one being mild and three being gastric failure.

There is no consistent single treatment that is proven to work for gastroparesis, and there is no cure. Treatments can consist of:

Diet changes (3 Step Gastroparesis Diet, liquid diet, oral sole source nutrition)

Prokinetic (motility stimulating) drugs

Anti-nausea medications

Proton-pump inhibitors

Gastric stimulator/gastric pacemaker

Pyloric botox and dilation

G-POEM/pyloroplasty

Post-pyloric tube feeding

Gastric venting/draining

Parenteral nutrition

IV fluids

Other surgical interventions like gastrectomy or rarely, transplant

Gastroparesis is a terrible disease and I hope that if any of these symptoms resonate with you that you can get checked out. I was misdiagnosed for a long time before getting a proper gastroparesis diagnosis, and all it took was a gastric emptying study. This is ESPECIALLY true if you're having post-COVID gastrointestinal problems that are not improving. I almost died from starvation ketoacidosis because of how serious my GP got in a short period of time post-COVID (I had GP before COVID), and now I'm tube reliant for all my nutrition and hydration.

Stay safe friends!

[wheelie-sick]

Explaining dysphagia

Dysphagia is simultaneously a symptom and a diagnosable condition. Most people think of it (if they think of it at all) as the choking on food disease but in reality it's much more complicated than that.

There are four categories of dysphagia: oropharyngeal, esophageal, esophagogastric, and paraesophageal

only two of those categories (oropharyngeal and esophageal) are commonly used and diagnosed so those are the main two I'll be talking about.

The diagnosis of dysphagia is a fairly complicated process involving a lot of radiological testing and things stuck up your nose and down your throat.

lost the source :(

source

the ICD 10 further divides dysphagia into unspecified, oral phase, oropharyngeal phase, pharyngeal phase, pharyngoesophageal phase, and other dysphagia which includes cervical dysphagia and neurogenic dysphagia

Oropharyngeal dysphagia

Oropharyngeal dysphagia occurs when someone has difficulty initiating a swallow. It's often accompanied by coughing, choking, feeling food stick in the throat, and nasal regurgitation. Other symptoms include frequent repetitive swallows, frequent throat clearing, a gargly voice after meals, hoarse voice, nasal speech and dysarthria, drooling, and recurrent pneumonia.

Oropharyngeal dysphagia is diagnosed with a modified barium swallow and/or a transnasal video endoscopy.

Some of the consequences of oropharyngeal dysphagia include aspiration pneumonia, upper respiratory infections, and weight loss. Common treatment includes rehabilitative swallowing exercises, botox, surgery, and/or a feeding tube.

Esophageal Dysphagia

Esophageal dysphagia is dysphagia where there is a problem with the passage of food or liquids through the esophagus between the upper and lower esophageal sphincter. Esophageal dysphagia is usually a result of abnormal motility in the esophagus or a physical obstruction to the esophagus. Symptoms of esophageal dysphagia vary depending on cause.

Motility: People with esophageal motility disorders will experience problems with swallowing both liquids and solids. Motility disorders consist of abnormal numbers of contractions in the esophagus, abnormal velocity of contractions, abnormal force of contractions, abnormal coordinated timing of contractions, or several of these simultaneously. People with esophageal motility disorders may also experience spasms or chest pain.

Obstruction: People with an esophageal obstruction will have more difficulty swallowing solids than liquids.

Some symptoms of both include pain when swallowing, the inability to swallow, sensation of food being stuck in your throat or chest, drooling, and regurgitation.

Esophageal dysphagia can be diagnosed with a barium swallow, upper endoscopy, esophageal manometry, and an endoFLIP.

Some common treatments for esophageal dysphagia include medication, esophageal dilation, surgery, stent placement, and/or a feeding tube.

Esophagogastric Dysphagia

Esophagogastric dysphagia occurs when there is a problem with material passing from the lower esophageal sphincter into the gastric fundus.

Paraesophageal Dysphagia

Paraesophageal dysphagia occurs when the esophagus is narrowed due to extrinsic compression.

The ICD 10 Classifications

Oral phase - difficulty moving food or liquid to the back of the throat

Oropharyngeal phase - difficulty initiating swallowing

Pharyngeal phase - difficulty swallowing when food or liquid is at the top of the throat

Pharyngoesophageal phase - unable to find information

Other dysphagia- cervical dysphagia (caused by problems with the cervical spine) or neurogenic dysphagia (caused by problems with the central or peripheral nervous system)

Sources

x x x

+ some others I definitely (/sarcasm) didn't lose the link to

[thatdruidgal]

09.03 placebo effect

Science and Magick

“…the efficacy of magick will depend on the extent to which the act has meaning for the practitioner…”

Placebo Effect

Sourced at https://skygardentarot.com/2020/02/22/magick-and-the-placebo/ and https://www.cbc.ca/natureofthings/episodes/brain-magic-the-power-of-the-placebo

Placebos can have powerful — and real — effects on our mind and body. (A patient experienced relief from the symptoms of a painful medical condition, even though she knew she was taking sugar pills.)

Placebos cause changes in neurobiological signaling pathways and have measurable physiological effects on heart rate, blood pressure (including affecting coronary blood flow and fainting), gastrointestinal tract (including contractions, nausea, motion sickness, bowel motility, functional gastrointestinal disorders, the pulmonary system, especially asthma), immune responses (such as psoriasis, allergic rhinitis, lupus erythematosus).

If we operate from the paradigm that magick is a placebo then by definition the efficacy of magick will depend on the extent to which the act has meaning for the practitioner.

Like what you see? Consider supporting me! ko-fi.com/thatdruidgal

[theautisticdoctor]

Entry #012

Hypermobility

A problem many autistic fellows of mine, including me, are suffering from is hypermobility. It's a underdiagnosed, underrecognized part of autism.

I personally deal with Ehlers-Danlos Syndrome (EDS), which runs in my family. My great-grandmother, grandmother, and mother all have it, and so do I. It comes with a host of symptoms: atrophic scars, mitral valve insufficiency, postural / orthostatic tachycardia syndrome, gastric motility disorder, pelvic and bladder dysfunction, extremely soft and stretchy skin, and, of course, extreme hypermobility. I can bend my joints in ways that I only learned in medical school was abnormal, and I’ve often felt like a bit of a freak during skills practices. I remember asking an orthopaedic surgeon during training why people couldn’t do 90 degrees flexion and extension with their forefeet, only to be met with confusion. When I demonstrated what I meant, the look on his face was one of pure astonishment. This highlights how different our experiences can be and how misunderstood they often are.

One of the most frustrating parts is not being taken seriously by some doctors. I’m lucky to have a medical degree and trusted colleagues I can consult, but many autistic individuals don’t have this luxury. Too often, our symptoms are dismissed or attributed to our mental health, leading us to delay seeking help until things get really bad. Please, don’t wait. The longer you put off seeing a doctor, the harder it becomes to treat your symptoms. Find a physician who listens and takes you seriously. Hypermobility doesn't necessarily mean you have EDS, but hypermobile or not, moving and living isn’t easy. Chronic exhaustion is real and debilitating. I touched on managing energy levels in entry #003 with routines based on my modified spoon theory, which I call the cutlery theory. I’ll dive deeper into this in a future post.

Living with hypermobility means constant joint pain, frequent dislocations, and early arthritis. I’ve never known a pain-free day, and overdoing it physically just makes things worse. Recovery takes time, and I’m still figuring out if physical and mental fatigue recover together or separately. Overstraining definitely not only impacts physical, but also my mental state. Not everyone can access rehabilitation programs, but there are steps you can take on your own to make it a little easier or better. Start by tracking your symptoms to identify patterns. This can help you find ways to support yourself. Working with a physiotherapist or occupational therapist is ideal, but you can also use trial and error to find what works for you. I’m always here to brainstorm and offer support.

I’m a big believer in creative therapy. One exercise is to color in a body image to show where you feel comfortable, uncomfortable, or in pain. This helps you and your healthcare providers understand your condition better and develop a personalised treatment plan.

Also, braces can be a lifesaver for dislocated or overstretched joints, even though I hate wearing them. They help prevent further injury and aid in recovery. Despite the awkward looks and comments, they’re definitely worth it.

In conclusion, hypermobility is often a comorbidity of autism. It can cause mental fatigue and chronic pain, among other symptoms. Don’t suffer in silence, but find ways to accommodate yourself and make life easier. Medication and surgery aren’t always the answers, although they can help. Awareness and lifestyle adjustments can make a big difference too. Talk to your physician, physiotherapist, occupational therapist, and fellow patients to find what works for you.

[3liza]

ok i took a big chunk of time off from eating in the middle of the day and just resumed eating/made up the calories at the end of the day and i think that does help me a lot. there are two schools of thought with gastroparesis eating and one is "eating small meals all the time to keep your guts moving" and the other one is "do intermittent fasting to give your guts a break from having to digest stuff and let your last meal process fully". they both work for different people but i think I'm the latter type.

unsurprisingly a huge percentage of people (mostly girls) who have anorexia and bulimia diagnoses in early life end up being diagnosed as gastroparetics once someone actually does a gastric emptying test. people used to attribute this wholly to eating disorders CAUSING the gastroparesis (which can happen), but once they started testing patients who hadn't had an eating disorder long enough to develop any secondary health effects, they found they were still turning up a ton of gastroparesis cases. the thinking now is that the gastroparesis happens first for a large number of patients who (reasonably) develop either restrictive eating or cyclic vomiting because they physically cannot digest food at a normal pace. this was definitely the case with me, i never had ARFID or any kind of picky eating, food was just physically painful for me even as a very young child and that morphed into an eating disorder as a teen when I observed correctly that simply not eating food for long periods of time was the one thing that reduced my discomfort. not one single adult in my life knew enough to suspect it was anything except basic teen girl body image anorexia, which it mostly wasn't.

obviously losing body mass isn't my goal here and isn't healthy at my size anyway so my technique is to just increase calories per mass as much as possible and eat lots of very dense fats and proteins and of course supplement vitamins. i can keep my body mass pretty steady this way.

anyway if you're a parent or caretaker and you have a kid with an eating disorder try not to worry too much (stressing ED patients out or making a big deal out of the ED is usually the wrong move) but take them to the gastroenterologist and get them checked for motility, allergies, and celiac disease before you assume they're having an entirely psychological problem (it can be a combination of physical and psychological reasons). if someone had caught this when i was 15 it could potentially have prevented a lot of other health problems.

[infernape]

turns out i have a rare esophageal motility disorder 😍fuck

[gauricmi]

Breakthroughs in Treatment: Gastric Motility Disorder Drug Unveiled

Gastric motility disorders can significantly impact an individual's quality of life, leading to symptoms such as bloating, nausea, and delayed gastric emptying. Fortunately, recent advancements in medical research have led to the development of promising treatments, including the introduction of novel Gastric Motility Disorder Drug therapies.

Exploring the Potential of Gastric Motility Disorder Drug:

Targeted Therapeutic Approach: Gastric Motility Disorder Drug therapies aim to address the underlying causes of gastric dysmotility, targeting specific receptors or pathways involved in gastrointestinal motility regulation. These drugs offer a more targeted and effective approach to symptom management compared to traditional treatments.

Improved Symptom Management: Clinical trials of Gastric Motility Disorder Drug therapies have shown promising results in improving symptoms associated with gastric motility disorders. From reducing bloating and abdominal discomfort to enhancing gastric emptying, these drugs offer hope for individuals struggling with gastrointestinal symptoms.

Benefits of Gastric Motility Disorder Drug Therapy:

Enhanced Treatment Efficacy: Gastric Motility Disorder Drug therapies offer enhanced treatment efficacy compared to conventional approaches. By targeting specific mechanisms involved in gastric dysmotility, these drugs can effectively alleviate symptoms and improve overall gastrointestinal function.

Increased Patient Compliance: The introduction of Gastric Motility Disorder Drug therapies may improve patient compliance with treatment regimens. With the potential for fewer side effects and improved symptom relief, patients are more likely to adhere to their prescribed medication, leading to better long-term outcomes.

Potential for Personalized Medicine: As research in Gastric Motility Disorder Drug therapies continues to advance, there is potential for personalized medicine approaches tailored to individual patient needs. By identifying specific genetic or molecular markers associated with gastric motility disorders, clinicians can prescribe targeted therapies for optimal treatment outcomes.

Get More Insights On This Topic: Gastric Motility Disorder Drug

[soniez]

Choosing the Right Gastrointestinal Tract Drug – Factors to Consider

The gastrointestinal (GI) tract is a complex system responsible for digestion and absorption of nutrients.  Given its critical function, disorders affecting the GI tract can significantly impact overall health and quality of life.  Selecting the right medication to treat these conditions is essential for effective management and recovery.  Centurion HealthCare, a leading gastrointestinal tract drugs supplier in India, offers a range of high-quality medications designed to address various GI disorders.  In this article, we will explore the factors to consider when choosing the right gastrointestinal tract drug, and why Centurion HealthCare stands out in the best pharmaceutical industry in India.

Understanding Gastrointestinal Tract Disorders

GI tract disorders encompass a wide range of conditions affecting different parts of the digestive system, including the esophagus, stomach, intestines, liver, pancreas, and gallbladder.  Common GI disorders include:

Gastroesophageal Reflux Disease (GERD)

Peptic Ulcer Disease

Irritable Bowel Syndrome (IBS)

Inflammatory Bowel Disease (IBD)

Hepatitis

Pancreatitis

Each condition requires specific treatment strategies and medications to manage symptoms, promote healing, and prevent complications.

Factors to Consider When Choosing a Gastrointestinal Tract Drug

Choosing the right drug for treating GI disorders involves multiple factors, including the specific condition, the patient’s medical history, and potential side effects.  Here are key considerations:

1.   Accurate Diagnosis

An accurate diagnosis is the first step in selecting the appropriate medication.  Physicians use various diagnostic tools such as endoscopy, colonoscopy, imaging studies, and laboratory tests to identify the specific GI disorder.  Understanding the underlying cause and severity of the condition is crucial for effective treatment.

2.   Mechanism of Action

Different gastrointestinal tract drugs work through various mechanisms to achieve therapeutic effects.  Understanding how a drug works helps in selecting the most suitable option.  Common mechanisms include:

Antacids:  Neutralize stomach acid, providing quick relief from heartburn and indigestion.

Proton Pump Inhibitors (PPIs):  Reduce the production of stomach acid, effective in treating GERD and peptic ulcers.

H2 Receptor Antagonists:  Decrease acid production by blocking histamine receptors in the stomach lining.

Prokinetics:  Enhance gut motility, useful in conditions like gastroparesis.

Antispasmodics:  Relieve intestinal cramps and spasms, often used in IBS treatment.

Anti-inflammatory Drugs:  Reduce inflammation in the GI tract, essential for managing IBD.

3.   Efficacy and Safety

The efficacy and safety profile of a drug are critical factors in the decision-making process.  Clinical trials and real-world studies provide valuable information on a drug’s effectiveness and potential side effects.  Physicians must weigh the benefits against the risks to ensure the chosen medication offers the best possible outcome for the patient.

4.   Patient-Specific Factors

Each patient is unique, and various individual factors can influence drug selection.  These include:

Age:  Certain drugs may be more suitable for children, adults, or the elderly.

Medical History:  Pre-existing conditions, such as kidney or liver disease, can affect drug metabolism and tolerance.

Allergies:  Patients with known drug allergies must avoid medications that could trigger adverse reactions.

Concurrent Medications:  Drug interactions can impact efficacy and safety, requiring careful consideration of all medications the patient is currently taking.

5.   Route of Administration

The route of administration can affect the drug’s efficacy and patient compliance.  Common routes for GI drugs include:

Oral:  Tablets, capsules, and liquids are convenient for most patients.

Intravenous:  Used in severe cases or when oral administration is not feasible.

Topical:  Suppositories and enemas are used for localized treatment in the lower GI tract.

6.   Cost and Availability

Cost can be a significant factor, especially for long-term treatments.  Generic versions of drugs often offer the same efficacy as brand-name medications at a lower cost.  Availability of the drug in the local market is also crucial to ensure uninterrupted treatment.

Centurion HealthCare:  Leading the Way in GI Tract Drug Supply

Centurion HealthCare has established itself as a premier gastrointestinal tract drugs supplier in India, renowned for its commitment to quality, innovation, and patient care.  Here’s why Centurion HealthCare is a trusted name in the best pharmaceutical industry in India:

1.   Comprehensive Product Range

Centurion HealthCare offers a wide range of gastrointestinal tract drugs, catering to various GI disorders.  Their product portfolio includes antacids, PPIs, H2 receptor antagonists, prokinetics, antispasmodics, and anti-inflammatory medications, ensuring comprehensive treatment options for healthcare providers.

2.   Quality Assurance

Quality is at the heart of Centurion HealthCare’s operations.  The company adheres to stringent quality control measures, from raw material sourcing to final product testing, ensuring that every medication meets international standards for safety and efficacy.

3.   Research and Development

Centurion HealthCare invests heavily in research and development to stay at the forefront of pharmaceutical innovation.  Their R&D team continuously works on developing new formulations and improving existing products to address emerging healthcare needs.

4.   Patient-Centric Approach

Understanding that each patient is unique, Centurion HealthCare adopts a patient-centric approach in drug development and supply.  Their medications are designed to provide maximum therapeutic benefit with minimal side effects, enhancing patient outcomes and quality of life.

5.   Global Reach

As a leading gastrointestinal tract drugs supplier, Centurion HealthCare has a robust distribution network that ensures their products are available not only across India but also in international markets.  Their commitment to excellence has earned them a reputation as a reliable partner for healthcare providers worldwide.

6.   Affordability

Centurion HealthCare is dedicated to making high-quality medications accessible to all.  Their cost-effective solutions, including generic versions of popular GI drugs, help reduce the financial burden on patients while maintaining high standards of care.

Conclusion

Choosing the right gastrointestinal tract drug involves careful consideration of various factors, including accurate diagnosis, mechanism of action, efficacy, safety, patient-specific factors, route of administration, and cost.  Centurion HealthCare, as a leading gastrointestinal tract drugs supplier in India, excels in providing high-quality, effective medications that cater to the diverse needs of patients with GI disorders.

With a commitment to quality, innovation, and patient-centric care, Centurion HealthCare stands out in the best pharmaceutical industry in India.  Their comprehensive product range, stringent quality assurance, advanced R&D, global reach, and affordability make them a trusted partner for healthcare providers seeking reliable solutions for GI tract disorders.

By choosing Centurion HealthCare, you can be confident in the quality and efficacy of the medications you are prescribing or consuming, ensuring the best possible outcomes for gastrointestinal health.

[cannabiscomrade]

Theres motility specialistist?!? <- Guy who has been diagnosed with gp for 7 years. I was diagnosed at 14 and had a hard enough time finding a gastroenterologist that would see me, and then I turned 18 during COVID and I just... gave up on professional treatment for a while. To be fair I only have a mild to moderate case (I think) but damn...

Yes! They specialize in esophageal, gastric, and intestinal dysmotility! I highly encourage seeing if there are any in your area.

If you have the luxury of travel, some clinics will do one in-person appointment and then do the rest via telehealth. They can be put through out of network exceptions if you’re in the US. Mayo Clinic and Cleveland Clinic have the leading motility clinics that I’m aware of, but there are other motility specialists.

List of US Neurogastroenterologists and Motility Specialists (r/gastroparesis)

G-PACT list of US Motility Doctors

The Association of Gastrointestinal Motility Disorders also has lists of physicians, centers, dietitians, and other experts from around the world.

[frilledshark-enthusiast]

idea

I hc Dee as having chronic illnesses specifically Gastrointestinal (Gastroparesis is a condition that affects the normal spontaneous movement of the muscles (motility) in your stomach. Ordinarily, strong muscular contractions propel food through your digestive tract.Jun 11, 2022) so basically a paralyzed stomach that causes someone to throw up every-time they eat. A lot of people with this disorder need feeding tubes and I think Dee would be no exception. Lif and heavy would find stickers and patterned tape to keep it on and Dee would never admit it but they love the stickers. I also think they have Emetophobia and unfortunately kinda just have to get used to throwing up (less now that they have the tube). If heavy ever wither convinced glam and Vicky into getting a cat (or just feeding a stray) it would try to catch the tube and Dee would yell about ableism even though they secretly love how much attention the cat pays to them. They have really bad stomach pain and glam got them a hot water bottle to help with it. They love freaking heavy out when they have to change it by pulling it out if front of him. Also heavy being a little shit eats dees favorite foods in-front of them whenever they fight.

[drguptasclinic1]

Unraveling the Enigma: Exploring the Causes of Infertility in Men and Women

Infertility, a condition that affects millions of couples worldwide, can be a source of immense emotional distress and frustration. While there are numerous factors that can contribute to infertility, understanding its underlying causes is essential for effective diagnosis and treatment. In this article, we delve into the multifaceted causes of infertility in both men and women, shedding light on the complex interplay of biological, environmental, and lifestyle factors.

Causes of Infertility in Women

Ovulation Disorders: Irregular or absent ovulation can hinder conception. Conditions such as polycystic ovary syndrome (PCOS), thyroid disorders, and premature ovarian insufficiency (POI) can disrupt the ovulation process.

Fallopian Tube Damage: Blockages or damage to the fallopian tubes can prevent the egg from reaching the uterus for fertilization. Previous pelvic infections, endometriosis, or surgery may contribute to fallopian tube issues.

Uterine Abnormalities: Structural abnormalities in the uterus, such as fibroids or polyps, can interfere with embryo implantation and development, leading to infertility.

Age-related Factors: As women age, the quantity and quality of their eggs decline, making conception more challenging. Advanced maternal age is a significant risk factor for infertility.

Causes of Infertility in Men

Low Sperm Count or Quality: Issues with sperm production, motility, or morphology can impair fertility. Factors such as hormonal imbalances, genetic conditions, and lifestyle choices (e.g., smoking, excessive alcohol consumption) can affect sperm health.

Varicocele: A varicocele, an enlargement of the veins within the scrotum, can lead to decreased sperm production and quality. It is a common reversible cause of male infertility.

Testicular Factors: Conditions such as undescended testicles, testicular trauma, or infections can impact sperm production and function, contributing to infertility.

Ejaculatory Disorders: Disorders affecting the ejaculation process, such as retrograde ejaculation or erectile dysfunction, can hinder the delivery of sperm during intercourse.

Seeking Help from a Male Fertility Doctor

For couples struggling with infertility, consulting a male fertility doctor, also known as a reproductive urologist or andrologist, can provide valuable insights and guidance. These specialists are trained to evaluate and treat male infertility issues, offering diagnostic tests, fertility evaluations, and personalized treatment plans to address underlying causes and improve reproductive outcomes.

Conclusion

Infertility can stem from a myriad of factors affecting both men and women. By understanding the potential causes of infertility and seeking specialized care from a male fertility doctor specialist, couples can embark on a journey towards achieving their dream of parenthood. With advancements in reproductive medicine and personalized treatment approaches, there is hope for overcoming infertility challenges and building a family.

[theorganicnutritions]

Finding Your Best IBS Treatment Plan

Irritable bowel syndrome (IBS) is a common digestive disorder estimated to affect 10-15% of the entire population. Symptoms like cramping, abdominal pain, bloating, constipation and diarrhea can range from mild to completely debilitating.

While no medical cure exists for IBS, the good news is that many effective IBS treatment options are available to significantly ease symptoms. It simply requires working with your doctor to discover the best personalized treatment plan.

Getting Properly Diagnosed

Since IBS is what’s known as a diagnosis of exclusion, the first step is to rule out the possibility of other inflammatory bowel diseases like Crohn’s or Celiac with specific testing. These may include:

Stool tests check for underlying infections or other gut issues

Blood tests look for markers of inflammation indicating disease

Colonoscopy visually examines the large intestine

Food sensitivity testing reveals if certain foods worsen symptoms

Once other conditions are ruled out, your doctor will make an official IBS diagnosis, the details of which will guide your treatment plan.

IBS Treatment Plans Depend on Type

There are four types of IBS, classified by what digestive symptoms are most prominent:

IBS with Constipation (IBS-C): Hard, infrequent stools IBS with Diarrhea (IBS-D): Frequent loose, watery stools.

IBS with Mixed Bowel Habits (IBS-M): Alternating constipation and diarrhea IBS Unspecified: Insufficient abnormality of stool consistency

Identifying your IBS type allows your doctor to select suitable therapies.

Lifestyle Treatments for IBS Relief

Certain at-home care strategies may significantly control IBS flare-ups including:

IBS Diet - Limiting intake of high FODMAP foods like dairy, beans, wheat, onions, cabbage, and artificial sweeteners can ease stool issues in 75% of IBS patients.

Stress Reduction - Stress dramatically exacerbates IBS problems, so relaxation techniques like meditation, yoga, massage are key.

More Exercise – Moderate activity at least 30 minutes daily calms the nervous system tied to digestive function.

Probiotics - These healthy gut bacteria in supplement form have been shown in studies to reduce bloating and pain.

Peppermint Oil - Shown to reduce spasms and cramping pain. Use enteric-coated capsules.

Prescription IBS Medications

If lifestyle adjustments aren’t providing enough relief, many traditional and newer medications can be very effective, including:

Antispasmodics – Helps relax intestinal muscles to reduce painful cramping and spasms

Antidiarrheals – Slows motility and stool frequency for IBS-D

Laxatives – Helps alleviate constipation with IBS-C

Low-dose Antidepressants – Alters pain signaling pathways between the brain and digestive system

Newer Agents - Prescription medications acting on neurotransmitters recently approved specifically for IBS-C and IBS-D.

Last Resort: FMT for IBS

For patients failing standard IBS treatment, research shows great promise for fecal microbiota transplantation (FMT).

This involves transplanting healthy donor stool containing balanced communities of gut bacteria into the patient’s colon via scope or enema.

Results demonstrating FMT eliminates IBS symptoms in many patients suggests disruptions to the gut microbiome play a key role in IBS development.

Finding Your Optimal Treatment Combination

Since IBS is multifactorial in cause, most experts recommend utilizing a combination approach tailored to your specific symptoms patterns.

This can mean exploring herbal supplements like peppermint capsules or artichoke leaf extract while also prioritizing daily stress-reduction practices and a modified FODMAP diet under the guidance of a registered dietician.

Your doctor may also suggest rotating various categories of medications every few months to achieve lasting relief without building tolerance.

Be patient and keep your physician informed of how you’re responding to each new IBS treatment addition or modification. It often requires tweaking strategies over several months before discovering your unique formula for success.

Hope for Life Without IBS Misery

If you feel like you’ve tried everything for your difficult-to-treat IBS with little success, don’t lose hope. The treatments options area is rapidly evolving!

Whether its emerging micobiome research showing fantastic success with FMT for stubborn IBS cases or newly approved medications targeting specific IBS symptom pathways, effective tools for relief are available.

Stay focused finding the right gastroenterologist who will personalize a therapy plan that finally quiet your symptoms for good. With a thoughtful multi-pronged approach, you can get your life back and start feeling like yourself again!

[pharmaceutical0]

Domperidone-Pharmaceutical Reference and Impurity Standards | Simson Pharma

Domperidone is a medication used to treat certain gastrointestinal disorders. It belongs to a class of drugs known as dopamine antagonists and has prokinetic properties, meaning it helps to improve the movement of food through the stomach and intestines.

Domperidone is commonly used to treat conditions such as nausea and vomiting, reflux esophagitis, gastroparesis (delayed gastric emptying), and other disorders that affect the gastrointestinal motility.

Know more:- https://www.simsonpharma.com/promotions/domperidone-impurity-standards