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Also preserved on our archive
By Mary Van Beusekom, MS
SARS-CoV-2, the virus that causes COVID-19, is more infectious than severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) viruses because it contains an enzyme that can efficiently circumvent a host cell's innate defense mechanism, Kobe University–led researchers in Japan suggest in the Journal of Virology.
The innate immune system attaches the molecular tag ISG15 to SARS-CoV-2's nucleocapsid protein, which contains the virus's genetic material, inhibiting viral replication. The team's laboratory experiments suggest that the virus's papain-like protease (PLpro) can remove the tag, recovering its ability to assemble new viruses and escape the innate immune response.
Discovery may lead to more effective drugs While the SARS and MERS viruses belong to the same virus family and also have an enzyme that can remove the ISG15 tag, their versions are less efficient and have a different primary target than that of SARS-CoV-2.
In a Kobe University news release today, senior author Ikuo Shoji, MD, PhD, said this finding may help guide the development of more effective and selective COVID-19 inhibitors that target SARS-CoV-2's nucleocapsid protein.
"We may be able to develop new antiviral drugs if we can inhibit the function of the viral enzyme that removes the ISG15 tag," he said. "Future therapeutic strategies may also include antiviral agents that directly target the nucleocapsid protein, or a combination of these two approaches."
Study Link: journals.asm.org/doi/10.1128/jvi.00855-24
Press Release: www.eurekalert.org/news-releases/1061645
#mask up#covid#pandemic#wear a mask#public health#covid 19#wear a respirator#still coviding#coronavirus#sars cov 2
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Master Post: The Yan Papers & Supporting Evidence of an Unrestricted Bioweapon
Yan Reports
Unusual Features of the SARS-CoV-2 Genome Suggesting Sophisticated Laboratory Modification Rather Than Natural Evolution and Delineation of Its Probable Synthetic Route
SARS-CoV-2 Is an Unrestricted Bioweapon: A Truth Revealed through Uncovering a Large-Scale, Organized Scientific Fraud
The Wuhan Laboratory Origin of SARS-CoV-2 and the Validity of the Yan Reports Are Further Proved by the Failure of Two Uninvited "Peer Reviews"
Birger Sørensen, Angus Dalgleish & Andres Susrud
The Evidence which Suggests that This Is No Naturally Evolved Virus: A Reconstructed Historical Aetiology of the SARS-CoV-2 Spike
Steven C. Quay Bayesian Analysis
A Bayesian analysis concludes beyond a reasonable doubt that SARS-CoV-2 is not a natural zoonosis but instead is laboratory derived
Long history of China's CCP and Biowarfare: Analysis from Clare M. Lopez, Director of U.S. Geostrategic Security Issues for the Near East Center for Strategic Engagement (NEC-SE)
The Role of Biological Warfare in China’s Drive for Global Hegemony (Part 1) & How a CCP Operation Ensnared the US Government (Part 2)
Mixed Messaging from U.S. Government on China’s Biological Weapons Program: The involvement of U.S. government entities with Chinese biological weapons scientists and entities is deeply concerning
“Better Late Than Never?”
China’s Biological Warfare Programme: An Integrative Study with Special Reference to Biological Weapons Capabilities by Dany Shoham
This study attempts to profile China’s biological warfare programme (BWP), with special reference to biological weapons (BW) capabilities that exist in facilities affiliated with the defence establishment and the military. For that purpose, a wide variety of facilities affiliated with the defence establishment and with the military are reviewed and profiled. The outcome of that analysis points at 12 facilities affiliated with the defence establishment, plus 30 facilities affiliated with the PLA, that are involved in research, development, production, testing or storage of BW. This huge alignment might be regarded as superfluous, ostensibly; yet, considering the various factors discussed in the present study, the overall derived picture of the Chinese BW-related alignment is not at all surprising. The chances that an outstanding state like China would ignore new avenues of BW designing and deployment are a priori slim, if any. China, in all likelihood, is and will persist as a paramount BW possessor.
‘Virus warfare’ in China military documents
Chinese military scientists discussed the weaponisation of SARS coronaviruses five years before the COVID-19 pandemic, outlining their ideas in a document that predicted a third world war would be fought with biological weapons.
The Secret Speech of General Chi Haotian
The Secret Speech of General Chi Haotian. In 2005, THE EPOCH TIMES acquired a secret speech given by Defense Minister Chi Haotian to high-level Communist Party Cadres sometime before his retirement in 2003. Details given in Chi’s speech coincide with previously unpublished defector testimony on Sino-Russian military plans.
A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence (2015)
The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome (MERS)-CoV underscores the threat of cross-species transmission events leading to outbreaks in humans. Here we examine the disease potential of a SARS-like virus, SHC014- CoV, which is currently circulating in Chinese horseshoe bat populations1. Using the SARS-CoV reverse genetics system2, we generated and characterized a chimeric virus expressing the spike of bat coronavirus SHC014 in a mouse-adapted SARS-CoV backbone. The results indicate that group 2b viruses encoding the SHC014 spike in a wild-type backbone can efficiently use multiple orthologs of the SARS receptor human angiotensin converting enzyme II (ACE2), replicate efficiently in primary human airway cells and achieve in vitro titers equivalent to epidemic strains of SARS-CoV. Additionally, in vivo experiments demonstrate replication of the chimeric virus in mouse lung with notable pathogenesis. Evaluation of available SARS-based immune-therapeutic and prophylactic modalities revealed poor efficacy; both monoclonal antibody and vaccine approaches failed to neutralize and protect from infection with CoVs using the novel spike protein. On the basis of these findings, we synthetically re-derived an infectious full-length SHC014 recombinant virus and demonstrate robust viral replication both in vitro and in vivo. Our work suggests a potential risk of SARS-CoV re-emergence from viruses currently circulating in bat populations.
The China-Led WHO Report on Coronavirus Is Deeply Suspect
The China-Led WHO Report on Coronavirus Is Deeply Suspect by Lt. Col. (res.) Dr. Dany Shoham: EXECUTIVE SUMMARY: The WHO’s China-led international investigation into the origins of COVID-19 did not trace either the genomic derivation or the initial contraction of the virus that generated the pandemic. This could be because it did not look for an unnatural scenario or because a natural scenario did not in fact occur. China appears to have essentially dictated the proceedings of the investigation, the findings of which are deeply suspect.
Discovery of a novel merbecovirus DNA clone contaminating agricultural rice sequencing datasets from Wuhan, China
Discovery of a novel merbecovirus DNA clone contaminating agricultural rice sequencing datasets from Wuhan, China
An unreported CoV infectious clone in Wuhan
Csabai et al.
Unique SARS-CoV-2 variant found in public sequence data of Antarctic soil samples collected in 2018-2019
Host genomes for the unique SARS-CoV-2 variant leaked into Antarctic soil metagenomic sequencing data
Project DEFUSE: Defusing the Threat of Bat-borne Coronaviruses
DEFUSE proposal
Nuclear translocation of spike mRNA and protein is a novel pathogenic feature of SARS-CoV-2
The spike (S) protein appears to be a major pathogenic factor that contributes to the unique pathogenesis of SARS-CoV-2. Although the S protein is a surface transmembrane type 1 glycoprotein, it has been predicted to be translocated into the nucleus due to the novel nuclear localization signal (NLS) “PRRARSV”, which is absent from the S protein of other coronaviruses. Indeed, S proteins translocate into the nucleus in SARS-CoV-2-infected cells. To our surprise, S mRNAs also translocate into the nucleus. S mRNA colocalizes with S protein, aiding the nuclear translocation of S mRNA. While nuclear translocation of nucleoprotein (N) has been shown in many coronaviruses, the nuclear translocation of both S mRNA and S protein reveals a novel pathogenic feature of SARS-CoV-2.
SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro
Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line
Unnaturalness in the evolution process of the SARS-CoV-2 variants and the possibility of deliberate natural selection
Over the past three years, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has repeatedly experienced pandemics, generating various mutated variants ranging from Alpha to Omicron. In this study, we aimed to clarify the evolutionary processes leading to the formation of SARS-CoV-2 Omicron variants, focusing on Omicron variants with many amino acid mutations in the spike protein among SARS-CoV-2 isolates. To determine the order in which the mutations leading to the formation of the SARS-CoV-2 Omicron variants, we compared the sequences of 129 Omicron BA.1-related isolates, 141 BA.1.1-related isolates, and 122 BA.2-related isolates, and tried to dissolve the evolutionary processes of the SARS-CoV-2 Omicron variants, including the order of mutations leading to the formation of the SARS-CoV-2 Omicron variants and the occurrence of homologous recombination. As a result, we concluded that the formations of a part of Omicron isolates BA.1, BA.1.1, and BA.2 were not the products of genome evolution as is commonly observed in nature, such as the accumulation of mutations and homologous recombinations. Furthermore, the study of 35 recombinant isolates of Omicron variants BA.1 and BA.2, confirmed that Omicron variants were already present in 2020. The analysis we have shown here is that the Omicron variants are formed by an entirely new mechanism that cannot be explained by previous biology, and knowing the way how the SARS-CoV-2 variants were formed prompts a reconsideration of the SARS-CoV-2 pandemic.
Further Supporting Evidence
Anomalies in BatCoV/RaTG13 sequencing and provenance
Time Shows That The ‘Paranoid’ People Were Correct About COVID
Molecular Biology Clues Portray SARS-CoV-2 as a Gain-of-Function Laboratory Manipulation of Bat CoV RaTG13
The genetic structure of SARS-CoV-2 does not rule out a laboratory origin: SARS-COV-2 chimeric structure and furin cleavage site might be the result of genetic manipulation
A look at China’s biowarfare ambitions
Mountains of circumstantial evidence point toward early circulation of SARS-CoV-2
Breaking: SARS-CoV-2 Spike found in bacteria samples taken from China, 2019
Unique SARS-CoV-2 genomes found in Antarctic samples raises questions about SARS-CoV-2 origin, lineages
The Galveston National Lab and Wuhan Institute of Virology
US University Concedes It May Have Broken Law in Contract With Wuhan Lab
Judicial Watch: New Documents Reveal COVID-19 Vaccine Studies Used by HHS were Conducted in China
JW v HHS Wuhan August 31 2021 00696
Flavinkins Archives
THE NATIONAL INSTITUTES OF HEALTH AND ECOHEALTH ALLIANCE DID NOT EFFECTIVELY MONITOR AWARDS AND SUBAWARDS, RESULTING IN MISSED OPPORTUNITIES TO OVERSEE RESEARCH AND OTHER DEFICIENCIES
U.S. Army Medical Research and Development Command (USAMRDC) COVID-19 Common Operational Picture
SELLIN: Is China’s Military Making COVID-19 Variants?
Enhancing Protein Expression by Leveraging Codon Optimization
Engineered bat virus stirs debate over risky research
So, COVID-19 is a Bioweapon After All, The Times ExplainsSars-Cov-2 is a result of bioweapons research, and work of Ralph Baric and Peter Daszak
Journalistic Investigations
The origin of COVID: Did people or nature open Pandora’s box at Wuhan?
What really went on inside the Wuhan lab weeks before Covid erupted?New fresh evidence drawn from confidential reports reveals Chinese scientists spliced together deadly pathogens shortly before the pandemic, the Sunday Times Insight team report
New Emails Chronicle Lab-Leak Coverup in Real Time
Francis Collins and Anthony Fauci emailed about whether NIH funded Wuhan lab before secret call
Pentagon gave millions to EcoHealth Alliance for weapons research program
Leaked Chinese document reveals a sinister plan to ‘unleash’ coronaviruses
BREAKING: DOD CONTROLLED COVID ‘VACCINES’ FROM THE START UNDER NATIONAL SECURITY PROGRAM – LIED THE ENTIRE TIME – Were NEVER ‘Safe and Effective’
The role of the US DoD (and their co-investors) in "covid countermeasures" enterprise.
EVOLUTION OF A THEORY: Unredacted NIH Emails Show Efforts to Rule Out Lab Origin of Covid
The U.S. Keeps Offering China Its COVID Vaccines. China Keeps Saying No
Links between the University of Texas Medical Branch in Galveston and China’s People’s Liberation Army
Broken Bioweapon: Lack of mRNA Integrity in Pfizer Batches: All Regulators Knew This When they "Pretend-Approved" the Shots
Intelligence report warned of coronavirus crisis as early as November: Sources"Analysts concluded it could be a cataclysmic event," a source said
How Did Deborah Birx Get the Job?
Do Governments Track the Injury and Kill Rates from Biowarfare Agents Deployed as mRNA/DNA "Vaccines"?
Lab Leak Most Likely Origin of Covid-19 Pandemic, Energy Department Now Says
FBI Director Says Covid Pandemic Likely Caused by Chinese Lab Leak
Wuhan lab denied BSL4 access for SARS work without clear reasoning
Videos
Proof Government Lab Created COVID, Says Escaped Chinese Virologist Dr. Li-Meng Yan – Ask Dr. Drew
Virologist Dr. Li-Meng Yan Claims Coronavirus Lab 'Cover-Up' Made Her Flee China | Loose Women
The Dr. Jordan B Peterson Podcast, Viral: The Origin of Covid 19 | Matt Ridley | EP 310
Chinese Defector: China’s Weaponization of Covid-19
Was COVID-19 made inside a Chinese lab? | Under Investigation
One Billion COVID Jabs From The CCP? Dr. Naomi Wolf Breaks Down a Disconcerting Timeline
RTE Discussions #16: Examining DoD Involvement in the Pandemic (w/ Sasha Latypova)
Major Evidence China Is Making The Pfizer Vaccine Ingredients!
Naomi Wolf Bombshell: Has China Been Using COVID Vaccines To Decimate Western Democracies?!
LNP/mRNA Is "Natural Born Killer" Says Drug Inventor Dr. Richard Urso w/ Dr Kelly Victory – Ask Dr. Drew
COVID 'Good Material For Non-Traditional Bioweapon' To Ruin Economies: Chinese Virologist
Conversation with Dr. Jane Ruby: We cover the Government-Military-BioPharma Industrial Complex and get into the question Why?
SHOCKING REVELATION - DOCTOR EXPOSES COVID BIOWEAPONS PROGRAM & REVEALS VACCINE WILL KILL MILLIONS
COVID Lab Leak Evidence: Escaped Chinese Virologist Dr. Li-meng Yan & Brian O'Shea
Dr. David Martin: Pandemic Was "Biological Weapon of Genocide" w/ Dr. Kelly Victory – Ask Dr. Drew
Illegal Biolab in CA: Escaped Virologist Warns Of CCP Spy Links w/ Dr. Li-meng Yan – Ask Dr. Drew
Books
What Really Happened In Wuhan: A Virus Like No Other, Countless Infections, Millions of Deaths by Sharri Markson (2022)
Unrestricted Warfare: China's Master Plan to Destroy America by Qiao Liang & Wang Xiangsui (2015)
Podcasts
The Voice of Dr. Yan
Neither Accidental nor Occasional, the History of CCP’s Bioweapon Program Dr. Li-Meng Yan & Clare M. Lopez
No Amnesty Should Be Given Until Investigation of COVID-19 Origin
Pfizer’s Plan of Directed Evolution vs. COVID-19 Predictor in China – Does the Nightmare Become True?
Chinese Spy Balloon is another CCP’s Unrestricted Tactic Against America
CCP promoted novel fabricated data on nature origin of COVID-19
China’s new methodology warfare; Understanding the cognitive war
#covid-19#spike protein#biological WMD#Li-Meng Yan#Yan Papers#covid-19 vaccine#Unrestricted Warfare#fifth generational warfare#fav#save for later#masterpost#most important#important#wuhan institute of virology#wuhan virology lab#furin cleavage site#Clare M. Lopez#Sasha Latypova#virology
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trick or treat :3
Middle East Respiratory Syndrome
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Internal dissent within the mostly volunteer disease-news network known as ProMED—which alerted the world to the earliest cases of Covid, Middle East Respiratory Syndrome (MERS), and SARS—has broken out into the open and threatens to take down the internationally treasured network unless an external sponsor can be found.
The struggle for the future of the low-tech site, which also sends out each piece of content on a no-reply email list with 20,000 subscribers, has been captured in dueling posts to its front page. On July 14, a post by ProMED’s chief content officer, a veterinarian and infectious-disease expert named Jarod Hanson, announced that ProMED is running out of money. Because it is being undermined by data-scraping and reselling of its content, Hanson wrote, ProMED would turn off its RSS and Twitter feeds, limit access to its decades of archives to the previous 30 days, and introduce paid subscriptions.
Hanson is at the top of ProMED’s masthead, and the post was signed “the ProMED team,” which gave the announced changes the feeling of a united action. That turned out not to be the case. Very early on August 3, a post addressing “Dear friends and readers of ProMED” appeared on the site’s front page. The open letter was signed by 21 of its volunteer and minimally paid moderators and editors, all prominent physicians and researchers, and it makes clear that no unity existed.
“Although the [July post] was signed by ‘The ProMED Team,’ we the undersigned want to assure you that we had no prior knowledge,” the open letter stated. “With great sadness and regret … we, the undersigned, are hereby suspending our work for ProMED.”
The letter was taken off the site within a few hours, but the text had already been pushed to email subscribers. (WIRED’s copy is here.) On Friday, signers of the open letter said they had been locked out of the site’s internal dashboard. The site’s regular rate of posting slowed Friday and Saturday, but appeared to pick up again on Sunday.
Maybe this sounds like a small squabble in a legacy corner of the internet—but to public health and medical people, ProMED falling silent is deeply unnerving. For more than 20 years, it has been an unmissable daily read, ever since it received an emailed query in February 2003 about chat-room rumors of illnesses near Hong Kong. As is the site’s practice, that initial piece of intel was examined by several volunteer experts and cross-checked against a separate piece of news they found online. In its post, which is not currently accessible, ProMED reproduced both the email query and the corroborating information, along with a commentary. That post became the first news published outside China of the burgeoning epidemic of SARS viral pneumonia, which would go on to sweep the world that spring and summer—and which was acknowledged by the regional government less than 24 hours afterward.
Using the same system of tips and local news sources, combined with careful evaluation, ProMED published the first alerts of a number of other outbreaks, including two more caused by novel coronaviruses: MERS and Covid, which was detected via two online articles published by media in China on December 30, 2019. Such alerts also led the World Health Organization to reconsider what it will accept as a trustworthy notice of the emergence of epidemics. When the organization rewrote the International Health Regulations in the wake of SARS, committing member nations to a public health code of conduct, it included “epidemic intelligence from open sources” for the first time.
On the surface, the dispute between ProMED’s moderators and its leadership team—backed by the professional organization that hosts the project, the International Society for Infectious Diseases (ISID)—looks like another iteration of a discussion that has played out online for years: how to keep publishing news if no one wants to pay for it. But while that is an enduring problem, the question posed by the pause in ProMED’s operations is bigger than subscriptions. It looks more like this: How do you make a case for the value of human-curated intelligence in a world that prefers to pour billions into AI?
“ProMED might not always be the fastest, but it always provides important context that would not come through a news report,” says John Brownstein, an epidemiologist and chief innovation officer at Boston Children’s Hospital, who cofounded the automated online outbreaks database HealthMap and has collaborated with ProMED. “It’s the anti-social media, in a way. It’s a trusted voice.”
“ProMED possesses trained scientists that are able to discern what is really a problem and what is fake news,” says Scott J. N. McNabb, a research professor at Emory University’s Rollins School of Public Health and a former chief of public health surveillance at the US Centers for Disease Control and Prevention. “That's a tremendous advantage. So the reports are not coming from uninformed individuals, they're coming from professionals that have the medical expertise and public health expertise to really discern: ‘Is this genuine or not?’”
To understand why the fate of ProMED feels momentous, it helps to know a little bit about its history. The deliberately Web 1.0 site—it has no comment section and runs no graphics, so as not to stress the bandwidth in low-income nations—was created in 1994 and began being hosted by ISID in 1999. Its chief founder was the late John Payne Woodall, an entomologist and virologist who had a hand in most of the post-World War II build-up of global public health infrastructure, working for the Rockefeller Foundation, the WHO, and the CDC. (Cofounders were Stephen Morse, a professor of epidemiology at Columbia University’s Mailman School of Public Health, and Barbara Hatch Rosenberg, a biological weapons expert and former professor of microbiology at SUNY Purchase.)
Woodall believed that everyday people’s reports of events could constitute important early warnings of looming problems. The value of open source intelligence might seem obvious today, with every movement of the war in Ukraine, for instance, tracked on Twitter. But at the time, Woodall was challenging the accepted view that official public health surveillance data, gathered by governments and nongovernmental entities, was the key to understanding the havoc diseases can create. And he was leveraging early civilian access to the internet to do it. The site was established and scored its momentous early success exposing SARS all before Twitter launched and Facebook opened to the general public in 2006, and before the first iPhone went on sale in 2007.
The arrival of social media made it possible to instantly share information on all kinds of emergencies, from the Arab Spring to the Fukushima nuclear disaster to the Ebola epidemic in West Africa, and many accounts built audiences and monetization by conveying real-time alerts on arrays of subjects, often with no sourcing attached. The speed of Twitter (now known as X) could make ProMED’s careful verification look slow; though the organization pushed its content to its own Twitter account, those posts would often arrive after a breaking-news account got there first.
That left the site in a battle for funding. Its online host ISID lost revenue during the pandemic, as professionals stayed home from the conferences it had hosted. Internally, money began to dry up. One of the complaints aired in the open letter is that payments to the moderators, who receive a small stipend, are already in arrears and will be delayed for two more months.
“We are really up against a challenge of long-term, sustainable funding for operating ProMED,” says ISID’s CEO, Linda MacKinnon, who described the organization as sipping from project grants to keep core operations going on a budget of about $1 million a year. (MacKinnon spoke after the July 14 announcement but before the open letter was published.) “We have sort of grown organically over the years, from project to project that were all cobbled together, but not stepping back and putting together a business case of how to sustain, how to innovate. We have found ourselves partnering or collaborating with hospitals and academic institutions, but [not finding a] long-term home.”
Hanson, who published the post outlining the changes, told WIRED by email Friday evening: “Not a single entity has stepped forward with any type of funding to allow ProMED to continue to operate as it has for 28 years, which is to say open and free to the public. We have diligently pursued funding and messaged our plan for the past year and made our financial situation widely known.” He added, “Funders are primarily interested in the latest and greatest tools, so from their strategic perspective there's little value in ProMED—an aging but highly effective email surveillance system—to show to their leadership/benefactors.”
A deeper look at recent history shows that the battle over ProMED is not only about money, no matter how critical that might be. After Woodall, ProMED was led for years by Larry Madoff, an infectious disease physician and professor at the University of Massachusetts Medical School who built a wide network of collaborators. Madoff was abruptly dismissed by ISID two years ago, and both he and moderators who worked with him say they do not know why. MacKinnon will only say the action was “a board decision.” Madoff held the title of editor in chief; according to the site’s team listings, that title is not now in use.
Asked for comment, Madoff said this: “ProMED is a public good, and it ought to be freely available and remain so. It would be a shame if it lost large segments of its audience, many of whom are in low-resource settings, because of a failure of the parent organization to adequately provide resources.” He added: “Losing subscribers will hobble ProMED because it depends on its readers to send information. By not having that big subscriber base, by restricting your base through a paid model, you’re going to lose that.”
In 2020, Madoff told WIRED the site’s subscriber base was about 83,000 addresses (which cannot now be confirmed), whereas MacKinnon’s team set the current count at about 20,000. The open letter, among other demands, asks ISID to “ensure the administrative and editorial independence of ProMED's content and subscription policies. This could largely be accomplished by restoring a true Editor-in-Chief position with independent executive authority.”
WIRED reached out to all 21 signatories of the open letter to verify that it is authentic. As of Monday, six—Marjorie P. Pollack, Leo Liu, Maria Jacobs, Martin Hugh-Jones, Pablo M. Beldomenico, and Thomas Yuill—confirmed that it represents their views. “In the first six months of Covid, I averaged three hours of sleep a night,” says Pollack, an infectious disease physician who first joined the site in 1997, and wrote the December 30, 2019 post that first flagged the emergence of Covid. “We have been a collegial group of people, and we understood that ProMED represented a labor of love.”
Asked for comment on the open letter, MacKinnon emailed a statement Friday afternoon that was also posted to the ProMED site. ”We recognize that members of the ProMED community are concerned about the continuation of the platform,” it says in part. “We also know that we could have communicated changes more clearly to the community and apologize for any confusion and distress caused.” The statement went on to enumerate the site’s financial challenges and ended with a plea for “unrestricted operational funding and investment.”
The irony is that ProMED may have run out of runway just as past obstacles to its growth begin to evaporate. Unmeasured but apparently substantial portions of medical and public health users have departed Twitter following the shifts in its ownership and politics, and none of its replacements—Mastodon, Bluesky, Threads, or others—have accumulated the velocity or density to match. That could allow a revived ProMED to reestablish its utility as a trusted source that deserves broader support. But as even ProMED insiders acknowledge, that will need some kind of partner. Last week, supporters said they were hoping to lobby major public health graduate schools, or even the WHO’s new Hub for Pandemic and Epidemic Intelligence, based in Berlin, to lend ProMED financial support or a new institutional home.
“ProMED needs to be saved,” McNabb says. “We can move it into an academic setting, or into a broader context like a WHO collaborating center—wherever people feel comfortable and it can be funded appropriately. But we need to save it. It’s too important for public health.”
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Middle East respiratory syndrome-related coronavirus particle envelope proteins immunolabeled with rabbit HCoV-EMC/2012 primary antibody and goat anti-rabbit 10 nm gold particles.
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Global Oxygen Therapy Equipment Market Trends, Size, By Product Type (Bag-Valve Mask and Oxygen Source Equipment), By Portability (Portable and Stationary), By Application (Asthma, Pneumonia, Chronic Obstructive Pulmonary Disease (COPD), Respiratory Distress Syndrome, Cystic Fibrosis, and Others), By Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa)
The Global Oxygen Therapy Equipment Market was valued at US$ 35.58 Bn in 2022, estimated to reach US$ 60.08 Bn by 2030, with a CAGR of 6.68% from 2023-2030.
For those whose bodies don't obtain enough oxygen, oxygen therapy is a treatment option. Because tissue oxygenation is essential for appropriate physiological function and oxygen is needed for a variety of cell metabolisms. Oxygen therapy is a medical intervention that uses oxygen gas to provide both acute and chronic patient care. Equipment for oxygen treatment is used to treat a variety of respiratory illnesses since it offers supporting relief and complementary elements. It is now an essential component in properly managing several illnesses, including chronic obstructive pulmonary disease, asthma, and other forms of respiratory pain. Improved breathing, more energy, and heart failure prevention are among the advantages of oxygen treatment.
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Top Key Players/Manufacturers of Global Oxygen Therapy Equipment Market:
Linde plc, Invacare Corporation, Chart Industries, Koninklijke Philips N.V., BD, Smiths Medical, Teleflex Incorporated, Fisher & Paykel Healthcare Limited, Drägerwerk AG & Co. KGaA, Inogen, Inc.
Global Oxygen Therapy Equipment Market Production Breakdown Data by Top Regional scope:
NorthAmerica
Asia Pacific
Europe
Latin America
Middle East
By Drivers, Global Oxygen Therapy Equipment Market is primarily split into:
The rise in tobacco use and the prevalence of respiratory disorders, the preference for standalone oxygen therapy equipment over portable equipment, and ongoing technological advancements in the field of oxygen therapy all contribute to the growth of the oxygen therapy equipment market. However, the market expansion is hampered by strict regulatory restrictions that could delay the product approval of oxygen therapy goods. Opportunities for market expansion are anticipated to arise from an increase in the patient pool suffering from respiratory disorders.
By Restraints, Global Oxygen Therapy Equipment Market is primarily split into:
The obstacles that will limit market expansion are the high price of oxygen concentrators and their adverse effects, which include skin irritation and nasal dryness when used therapeutically. The market for oxygen therapy equipment will have difficulties as a result of the tight regulatory requirements that cause delays in product approval. Additionally, the availability of inexpensive substitutes made locally and Medicare reimbursement rate reductions for home oxygen therapy will act as market restraints and slow the market's development pace.
Get More Info: https://qualiketresearch.com/reports-details/Global-Oxygen-Therapy-Equipment-Market
By Application of Global Oxygen Therapy Equipment Market:
Asthma
Pneumonia
Chronic Obstructive Pulmonary Disease (COPD)
Respiratory Distress Syndrome
Cystic Fibrosis
Others
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Informationen des RKI zu MERS-Coronavirus
Das Middle East Respiratory Syndrome Coronavirus (MERS-CoV) wurde im April 2012 erstmals bei Patienten auf der arabischen Halbinsel nachgewiesen. Die Inkubationszeit beträgt 2-14 Tage. Eine Infektion kann asymptomatisch verlaufen oder zu leichten, aber auch schweren Erkrankungen führen. Bei schweren Verläufen kann sich eine Pneumonie entwickeln, die in ein akutes Atemnotsyndrom übergehen kann.…
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The Majestic Persian Cat Price in India: A Treasure Trove of Affection and Beauty
The Persian cat is one of the most recognizable and beloved cat breeds worldwide, renowned for its stunning physical appearance and charming personality. With their majestic long coats, sweet faces, and playful yet gentle nature, it's no wonder why Persian cats have captured the hearts of many feline enthusiasts.
Brief Overview of the Persian Cat Breed
The Persian cat breed originated in the Middle East, specifically in the region formerly known as Persia (now modern-day Iran). They were highly valued for their luxurious coats and were often kept as palace cats by royalty. Over time, Persian cats were introduced to Europe and other parts of the world, where they were bred with different cat breeds to create the diverse range of colours and facial structures we see today.
Persian Cat - Origin and History
The Persian cat's history dates back over 1,500 years, with records of long-haired cats existing in the region as early as the 16th century. They were highly prized for their beauty and were often given as gifts to royalty and nobility. In the late 19th century, Persian cats were introduced to the West and quickly gained popularity as a sought-after breed.
Persian Cat - Physical Characteristics
Coat Length, Texture, and Colours
Persian cats are known for their magnificent long coats, which can reach up to 6 inches in length. Their coats are soft fluffy and come in a variety of colours, including:
Solid: white, black, blue, chocolate, and red
Bi-colour: white with patches of another colour
Calico: predominantly white with patches of orange and black
Tabby: a mix of colours with a distinctive M-shaped marking on the forehead
Persian Cat - Eye Colours
Persian cats have large, round eyes that come in a range of colours, including:
Blue: a bright, vibrant blue
Normal: copper, gold, or green
Dual Colour Eyes: a combination of blue and copper or gold
Persian Cat - Facial Structures
Persian cats have distinct facial structures, which can be classified into three main categories:
Punch Face: a short, flat face with a short nose
Semi Punch Face: a slightly longer face with a more defined nose
Doll Face: a longer, more pointed face with a longer nose
Persian Cat Price in India
The Price of Persian cats in India can vary greatly depending on several factors, including:
Location: prices tend to be higher in urban areas like Mumbai and Delhi
Breeder reputation: reputable breeders may charge more for their kittens
Bloodline: purebred Persian cats with a strong lineage can command higher prices
Age: kittens are typically more expensive than adult cats
On average, the cost of a Persian cat kitten in India can range from ₹ 30k Onwards. Adult cats can cost between ₹30,000 to ₹40,000 onwards.
Persian Cat - Temperament and Personality
Persian cats are known for their friendly, calm, and gentle nature. They are:
Playful: enjoy playing with toys and interacting with their owners
Affectionate: love attention and cuddles
Quiet: not as vocal as other breeds
Adaptable: can thrive in a variety of living situations
Persian Cat - Grooming Needs
Persian cats require regular grooming to maintain their signature long coat. Tips for grooming include:
Brushing: daily brushing to prevent matting and tangling
Bathing: occasional bathing to keep the coat clean
Trimming: regular trimming to prevent overgrowth
Persian Cat - Health Issues
Persian cats are prone to certain health issues, including:
Eye problems: conjunctivitis, cataracts, and progressive retinal atrophy
Respiratory issues: brachycephalic syndrome and chronic bronchitis
Regular veterinary check-ups are essential to monitor their health.
Persian Cat for Sale: Find Your New Feline Companion
Are you searching for a Persian Cat for sale? Look no further! With their majestic long coats and endearing personalities, Persian Cats make wonderful pets for the right owner. Before making a decision, research and find a reputable breeder or rescue organization to ensure you're getting a healthy, well-socialized kitten or adult cat.
Remember, buying or adopting a Persian Cat is a significant decision, but with the right care and attention, it can be an incredibly rewarding experience for both you and your new feline friend.
Conclusion
The Persian cat is a majestic breed that makes a wonderful pet for the right owner. With their stunning physical appearance, charming personality, and playful yet gentle nature, it's no wonder why they remain a popular choice among cat enthusiasts. If you're considering bringing a Persian cat into your family, be prepared to provide the necessary care and attention to ensure they thrive. With the right love and care, a Persian cat can bring joy and companionship to your life for many years to come.
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MERS-CoV Spike Glycoprotein RBD Catalog number: B2016734 Lot number: Batch Dependent Expiration Date: Batch dependent Amount: 50 µg Molecular Weight or Concentration: 27.7 kDa Supplied as: Solution Applications: a molecular tool for various biochemical applications Storage: -80°C Keywords: MERS-CoV Spike Glycoprotein Receptor-Binding Domain, Middle East Respiratory Syndrome Coronavirus Spike…
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