#Medical and Healthcare

[mostly-funnytwittertweets]

[floral-ashes]

The fact that leagues of smart and rational trans adults who are informed about the evidence base for puberty blockers wish they could’ve taken them in their youth seems to me pretty darn conclusive evidence that the balance of risk and benefit is favourable.

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

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Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[incognitopolls]

This is asking about any significantly life altering or life threatening physical disease, infection, or accident that a medical specialist would have needed to test/treat you for.

Anon had a cancer scare that thankfully turned out to be benign, but some bad info and a long waitlist made for a very stressful time. They're wondering how many others have been there!

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We ask your questions so you don’t have to! Submit your questions to have them posted anonymously as polls.

[nightmaretour]

Okay now I've gotten myself angry again. Every time a medical professional is abusive/neglectful the overwhelming response is "Their job is so stressful and underpaid! They deal with so many rude and abusive patients, of course they're like that!!"

You know who else has stressful, underpaid jobs and deal with rude and abusive customers a lot? Retail workers. But if a retail worker started assaulting all of their customers you'd hear all about it, wouldn't you? The consequences would be enormous, and there would be an overwhelmingly negative response, even if it was exclusive to rude customers.

Now imagine this was the norm, and it was socially acceptable, encouraged even, in retail jobs to abuse and assault your customers whenever you feel like it, for any perceived sleight, just because they need to buy groceries and you have to serve them. It would be all over the news, it would be an international scandal with arrests all over the place, there would be exposés of the secret culture of abuse and assault in retail workplaces on every channel and news source with interviews with the victims. Everyone would know about it and everyone would care, because of course that's fucked up.

So why is it different when your victims are sick and rely on you to survive?

[ashersbunker]

SolMed week day 3: Invention/Experiment (I rushed this sorry)

See the host's post here!!!

[spaceacerat]

I see you disabled people who don't know your family medical history because your family members couldn't/wouldn't/weren't allowed to go to the doctor and never got diagnosed, or don't know your family.

I see you disabled people who didn't know you were disabled growing up, physically or mentally, maybe because your parents didn't have insurance and couldn't afford it/wouldn't take you seriously/didn't think it was a problem because they had it/doctors couldn't figure it out.

I see you disabled people who have bouts of an issue that you grew up with, that are/were infrequent enough that you never really thought about it and dealt with it on your own, and when you have one in front of people who weren't medically neglected, you wonder why they look so horrified as you describe it.

I see you disabled people who didn't/haven't had any amount of care or accommodation for their disability since it started, because you couldn't get diagnosed.

I see you disabled people who grew up thinking everyone had the same problem as you and that it was normal and so you accepted it, because you didn't understand how the human body worked and had no real frame of reference nor the language to ask for help, or the people around you saw it and just ignored it.

I see you disabled people only now understanding that what you experience is abnormal, and that there are things that can be done to help it, make it easier, or at least help you understand yourself better.

I see you disabled people that will never be able to get diagnosed or get the help you need, whether from being poor, lacking insurance, or any number of reasons.

This shit is hard, and there are people who will never quite understand your struggles. It doesn't seem to get talked about as much, but I wish it was. Please know I love you, and you aren't alone.

[animentality]

[ebenrosetaylor]

Healthcare can be expensive depending on the country you live in, but it is impossible to attain when you live in a country/place where no doctors can perform the procedures that you need. It may be due to lack of equipment, lack of specialized doctors, or no hospitals at all.

I am raising $ for my friend's mother Nabila @nabila60 This is urgent. Her life is at risk RIGHT NOW and we don't know how much longer she can hold on without treatment. If you answered this poll, please reblog it to reach more people. If you have ever had expensive hospital visits, please show sympathy to a mother who will die without treatment. You can save a life! Every donation counts.

[teamalcott]

The Science of Alcott Healthcare Products: How They Work to Improve Your Health

Alcott Healthcare Products are a popular choice for many people looking to improve their health and wellness. From vitamins and supplements to Healthcare and medical care products, Alcott offers a wide range of products that are designed to promote better health. But how do these products actually work to improve your health? In this article, we’ll explore the science behind Alcott Healthcare Products and how they can benefit your overall well-being.

High-Quality Ingredients

The foundation of every Alcott Healthcare Product is a unique blend of high-quality ingredients. Alcott’s team of scientists and researchers carefully select each ingredient based on their specific health benefits. This selection process is based on scientific research and ensures that each ingredient works together to deliver the maximum health benefits possible.

For example, Alcott’s line of vitamins and supplements contains essential vitamins and minerals that are critical for overall health and wellness. These ingredients are carefully selected and dosed to ensure that they work together effectively. Similarly, Alcott’s healthcare and medical care products contain natural ingredients that are proven to be effective for specific health concerns.

Advanced Manufacturing Processes

The manufacturing process is another critical aspect of the science behind Alcott Healthcare Products. Alcott uses state-of-the-art facilities and cutting-edge technology to ensure that each product is made to the highest standards of quality and purity. This process includes rigorous testing and quality control measures that ensure that every Alcott product meets the highest standards for safety and efficacy.

For example, Alcott’s products are made using advanced manufacturing techniques that ensure that each tablet or capsule contains the exact amount of active ingredients listed on the label. This precision ensures that each supplement is as effective as possible. Similarly, Alcott’s healthcare products are formulated using advanced techniques that allow the active ingredients to penetrate deep into the health and deliver maximum benefits.

Effective Absorption

The way that a healthcare product is absorbed by the body is crucial for its effectiveness. Alcott Healthcare Products are designed to be easily absorbed by the body, allowing the active ingredients to be delivered quickly and efficiently to the cells and tissues where they’re needed most.

The Importance of Clinical Trials

Clinical trials are a critical component of the scientific research that goes into Alcott Healthcare Products. These trials are designed to test the safety and efficacy of each product and ensure that it meets the highest standards of quality and effectiveness.

Alcott conducts extensive clinical trials on each of its products to ensure that they’re safe and effective for a wide range of health needs. These trials are conducted in accordance with strict guidelines and protocols and are reviewed by independent experts to ensure that they’re unbiased and scientifically sound.

Conclusion

In conclusion, the science behind Alcott Healthcare Products is the key to their success. By using high-quality ingredients, advanced manufacturing processes, and effective absorption techniques, Alcott is able to produce products that are safe, effective, and deliver real health benefits to consumers around the world.

Whether you’re looking to improve your overall health and wellness, or target specific health needs, Alcott Healthcare Products have a solution for you. So why not give them a try and experience the science of better health and wellness today?

[bethanythebogwitch]

I listened to reading of some askreddit threads (don't judge me, it's a guilty pleasure) about doctors and healthcare and I notices some major division on topics when the answers were from the doctor's POV and patients' POV. I'm of course not qualified to draw conclusions from this, nor is Reddit a good place to get data, but here are some recurring points I found where the doctor and patient position appeared to be different.

Doctor POV: we can always tell when people are faking pain for opioids. It's extremely obvious.

Patient POV: multiple doctors accused me of drug seeking when I was actually in agony from stones, appendicitis, endometriosis, a tumor, etc.

Doctor POV: people who try to diagnose themselves are really annoying and counter productive.

Patient POV: I only figured out what was wrong with me by searching the internet after multiple doctors dismissed or failed to diagnose me. Alternatively: I went in with a good idea of what was wrong based on past experiences/family history/ etc and the doctors didn't take me seriously. Some would even refuse to do tests to check if the self-diagnosis was correct.

Doctor POV: the phrase "I know my body" is usually used by people who don't know what they're talking about. We are the ones who know medicine so we can tell if you're sick or not.

Patient POV: I knew something was wrong with me because I know my body and know when something isn't normal. The doctors wouldn't take me seriously and told me nothing was wrong after only doing basic tests.

Again, Reddit is not a good place to get data as the nature of the website encourages people posting more sensational stories and exaggerating or fabricating stories to get upvotes. In addition, most of these stories are likely far from the average doctor and patient experience. However, it appears that there may (emphasis, may) be a disconnect between doctors and patients that involves doctors not taking patients seriously and thinking they know better than patients about their own bodies. It seems like defaulting to thinking patients exaggerate pain to seek drugs and that patients don't have any way of understanding their own health is really detrimental.

Do not take this post as me saying you shouldn't go to the doctor. If you need medical help, go to the doctor. The medical system isn't perfect, but it's the best we have. And go to an actual doctor, not a naturopath, homeopath, or other quack.

[inkskinned]

you have to go to work so you can pay for your doctor, who is not taking your insurance right now, and if you say i can't afford the doctor's you are told - get a better job. it is very sad that you are unwell, yes, but maybe you should have thought about that before not having a better job.

(where is the better job? who is giving out these better jobs? you are sick, you are hurting - how the hell are you supposed to be well enough for this better job?)

but you go to the doctor because you had the nerve to be hurt or sick or whatever else. and they tell you that it is because you have anxiety. you try your best. you are a self-advocate. you've done the reading (which sometimes pisses them off worse, honestly). you say it is actually adding to my anxiety, it is effecting my quality of life. so they say that you are fat. they say that all young people have this happen to them, isn't it a medical marvel! they say that you should eat more vegetables. they say that you probably just need to lose a little more weight, and that you are faking it for attention.

(what attention could this doctor possibly give? what validation? that's their fucking job, isn't it?)

there is always a hypochondriac, right. someone always tells you about a hypochondriac. or someone who is unnecessarily aggressive during the worst days of their life. or someone looking "for a quick fix". or some idiot who wasn't educated about how to properly care for themselves who just abandons their treatment. and again, the hypochondriac, the overly-cautious hysteric. these people don't deserve to be treated like humans (right), and since you might be one of these people, you also don't get treated like a human. because those people can really fuck with the system, you now have to pay for it. and besides. you're actually probably faking it.

(more often than not, you find a 2:1 ratio of these stories. for every "hypochondriac", there are 2 people who knew something was wrong, and yet nobody could fucking find it. the story often ends with pointless suffering. the story often ends with and now it's too late, and it's going to kill me.)

you are actually just making excuses. someone else got that procedure or that diagnosis and he's fine, you should be fine too. someone else said they watched a documentary about other inspirational people with your exact same condition, maybe you should be inspirational, too. you're just too morbid. your pain and your experience is probably just not statistically concerning. it is all self-reported anyway, and you're just being a baby.

(once, while sitting down in the middle of making coffee, you had the sudden, horrible thought - i could kill myself to make the pain stop. you had to call your best friend after that. had to pet your dog. had to cry about it in the shower. you won't, but that moment - god, fuck. the pain just goes on and on.)

you know someone who went in for routine surgery and said i still feel everything. they told her to just relax. it took her kicking and screaming before they figured out she wasn't lying - the anesthetic drip hadn't been working. you know someone who went in for severe migraines who was told drink water and lose weight. you know someone who was actively bleeding out and throwing up in the ER and was told you're just having a bad period.

in the ER there are always these little posters saying things like "don't wait! get checked today!" and you think about how often you do wait. how often the days spool out. you once waited a full week before seeing the doctor for what you thought was a sprained wrist. it had actually been broken - they had to rebreak it to set it.

but you go into the doctor. the problem you're having is immediate. the person behind the counter frowns and says we're not taking your insurance. you will be paying for this out-of-pocket.

they send you home with tylenol and a little health packet about weight loss or anxiety or attention deficit. on the front it has your birthday and diagnosis. you think about crying, and the words swim. it might as well say go fuck yourself. it might as well say you're a fucking idiot. it might as well say light your money on fire and lie down in it. and the entire fucking time - the problem persists.

it's okay. it's okay, it's just another thing, you think. it's just another thing i have to learn to live with.

[reasonsforhope]

"The Biden Administration last week [early December, 2023] announced it would be seizing patents for drugs and drug manufacturing procedures developed using government money.

A draft of the new law, seen by Reuters, said that the government will consider various factors including whether a medical situation is leading to increased prices of the drug at any given time, or whether only a small section of Americans can afford it.

The new executive order is the first exercise in what is called “march-in-rights” which allows relevant government agencies to redistribute patents if they were generated under government funding. The NIH has long maintained march-in-rights, but previous directors have been unwilling to use them, fearing consequences.

“We’ll make it clear that when drug companies won’t sell taxpayer funded drugs at reasonable prices, we will be prepared to allow other companies to provide those drugs for less,” White House adviser Lael Brainard said on a press call.

But just how much taxpayer money is going toward funding drugs? A research paper from the Insitute for New Economic Thought showed that “NIH funding contributed to research associated with every new drug approved from 2010-2019, totaling $230 billion.”

The authors of the paper continue, writing “NIH funding also produced 22 thousand patents, which provided marketing exclusivity for 27 (8.6%) of the drugs approved [between] 2010-2019.”

How we do drug discovery and production in America has a number of fundamental flaws that have created problems in the health service industry.

It costs billions of dollars and sometimes as many as 5 to 10 years to bring a drug to market in the US, which means that only companies with massive financial muscle can do so with any regularity, and that smaller, more innovative companies can’t compete with these pharma giants.

This also means that if a company can’t recoup that loss, a single failed drug can result in massive disruptions to business. To protect themselves, pharmaceutical companies establish piles of patents on drugs and drug manufacturing procedures. Especially if the drug in question treats a rare or obscure disease, these patents essentially ensure the company has monoselective pricing regimes.

However, if a company can convince the NIH that a particular drug should be considered a public health priority, they can be almost entirely funded by the government, as the research paper showed.

Some market participants, in this case the famous billionaire investor Mark Cuban, have attempted to remedy the issue of drug costs in America by manufacturing generic versions of patented drugs sold for common diseases."

-via Good News Network, December 11, 2023

[incognitopolls]

*Not counting routine checkups or normal doctor's visits– this is asking about serious illness, injury, etc where you were in a bed.

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We ask your questions so you don’t have to! Submit your questions to have them posted anonymously as polls.

[taviamoth]

Fundraiser for fashion designer Leena Sobieh's nephew to leave Gaza and continue his medical studies in Egypt. Please share and donate if you can.

[mysharona1987]