#Lidocaine

[macgyvermedical]

History of Lidocaine please?

Lidocaine was discovered in Sweden in the early 1940s.

About 1/3 of the surgeries at the time, including hernia repair and goiter, were done under local or regional anesthesia. The drug of choice for this was procaine. And frankly, procaine kind of sucked.

It was stored as a powder and needed to be mixed with saline and epinephrine very carefully in order to be useful. It degraded quickly in this mixture and was only effective for about 17 minutes once injected. It was also toxic at repeated or high doses. So surgeons had to be fairly quick about their surgeries.

And the room was there for a longer-acting, less toxic local anesthetic agent.

In 1943 a compound called LL30 was discovered. The lab personnel that discovered it had done a quick test on their own tongues, which anesthetized well. But it needed to be proven against procaine in both toxicity and effectiveness before a product could really be sold.

In 1944 the trials began. A man named Dr. Torsten Gordh headed up the experiments, using colleagues, patients, and students as test subjects. For the colleagues and patients, he offered the equivalent of about $16 in 2024 money to be in the study. For the students, they could choose between a copy of Gordh's thesis or a packet of American cigarettes.

Most of them chose the cigarettes.

The results were so stunningly superior to procaine that statistical analysis was never done. LL30 lasted a stunning 70 minutes compared to procaine's 17. It was also significantly less toxic, meaning more of it could be used.

LL30 would later be designated as lidocaine and sold under the brand name Xylocaine, which is still used today.

[whumpfish]

Extractions! (Tooth vs. Nail)

I've been wanting to do this one for a long time, for all you torture fans out there...

So I metabolize lidocaine like a motherfucker, and any time I get a local, I always have to get a second one halfway through whatever is being done. For the most part, doctors and dentists listen to me when I say this... for the most part.

Tooth

(The oral surgeon did not give me my second shot when I asked for it.)

1. Any fillings you have will collapse under the pressure of an extraction, even a medicated one. (I'm not sure if this is true for metal ones; all of mine are plaster.) It produces a half-crunch, half-thunk sound that reverberates in that half of your skull and sounds absolutely terrifying.

2. The pain of an unmedicated extraction is acute and radiating at the same time. The acute part feels more like having a stiletto stabbed upward into that space than a tooth taken out in a downward motion.

2a. In maxillary extractions, the stab goes straight up, and depending on the location of the tooth, that stab can feel pointed anywhere from your eyeball (frontmost) to right into your brain (rear).

2b. Mandibular extractions* stab downward from the chin (frontmost) to the hinge of your jaw and straight down your throat (rear).

3. The radiating part spreads like a flower blooming, from a concentrated central point outward in a rolling movement.

4. Your ears might pop like an airplane taking off as that blooming pain reaches the hinge of your jaw. Sometimes only in the one ear.

Nail

(I have been doing minor self-surgery** for years because I am genetically predisposed to ingrown nails, and if I don't catch it in time, they grow straight down and I have to extract them to be able to trim them. If I really don't catch it in time, they grow straight down and then curl backward, and I have to get an actual surgeon involved.)

1. Self-surgery, split off edge of nail, 0 to 1/2" down and backward: You have to wiggle these in a sawing/rocking motion back and forth in order to get that tiny bit of root to let go, and when you "saw" backward it feels more like a steak knife than a butter knife, this time moving with the direction of the nail. Then it reverses when you actually yank.

1a. The yank hurts more than the sawing, sharp like a stab from a steak knife instead of one being pushed in slowly.

1b. You will get the best whump out of a whumper splitting off the edges of the nail and doing this and then yanking the middle part

2. Medicated: Locals in the toe/finger area hurt like a bitch. They're sharp and needling like a stiletto to a paper cut, then if someone tried to pry that cut open. At the same time, they feel hot, almost burning. (Hotter than anesthetic being pushed through an IV, if you're familiar with that sensation.) And there are so many nerves involved that just the first round of locals takes 3-4 shots.

3. Unmedicated, grown down and backward, 1/2" to 3/4": The last time I went in, my surgeon said "given the amount of times I have to shoot you up, you'll probably hurt less if I just yank." (She was right.) This sumbitch goes in both directions, down/back from where the root is, then forward. The down/back is a stabbing pain. The forward is like somebody trying to pry open that papercut, a sensation probably caused by the fact that you are in fact messing with something stuck in a very small cut in the skin, in my case the cut was just caused by the nail that has now been removed.

4. If it is a toenail extraction, you are going to bleed significantly more than teeth or fingernails, because your body has to work harder pushing blood up through your leg veins than it does pushing it down into your shoe. Especially when you take a step. Ibuprofen makes this worse. If you take ibuprofen at all that day, expect your shoe to fill up when you take a step. (Mine did, scaring the tar out of everyone present, including me.)

Pain Intensity Verdict:

Teeth > Nails. By a LOT.

Happy yanking!!

*Because of nerve fuckery, dentists using the sonic cleaning tool despite my warnings results in a pain on the level of extractions, and the sensations described here are based on my experience with that.

**This never fails to horrify my friends. They'll see what I'm fixing to work on and say, "Oh ouch, that's bad, go to the doctor," and I'm just like "nah, just get me isopropyl alcohol and some office supplies, I got this."

[cardiomyopathies]

29

Source: @gentleward

[sonofapunk]

lidocaine my beloved

[pocketslut]

Just put lidocaine on my clit. Will report back with results

[vulpine111]

I wouldn't mind trying these products at some point. Not sure how much good a topical can do for someone with pain as deep as mine, but maybe it would take a little edge off.

[arctic-hands]

If I slap a prescription lidocaine patch on both knees would it make me too numb to hobble around?

[avaantares]

ZOMG1, where have these been all my life?? I'm going to wrap myself up like a mummy and feel great!

[mcatmemoranda]

When sutiring, don't use lidocaine with epinephrine for fingers, toes, ears, nose, and genitals.

[brooklyn-alley-ratcat]

In case this does happen to you, you should ask for Mepivacaine or “Mepi” as that is the anesthetic that doesn’t contain Epinephrine. Septocaine and Lidocaine both do but Septo contains a higher amount than Lifo does so just ask your dentist because they should carry all three in office for this very reason. -A dental assistant

So I go to the dentist and the appointment I had was not the appointment that I thought I was going to have (normal maintenance vs deep clean) so i warned the dentist "hey heads up I burn through dental anesthetics super quick and also I'd like to use as little as possible because putting the dental anesthetics in my body is the most painful part of the process unless I'm having a root canal or something" and she's like "Hmm. Okay. Is it just the injection site?" and I was like "no, it will feel like burning on the opposite side of my face and in my nose and eyes and stuff." And she was like "Hmm. Do you turn really red when this happens?" And I was like "I don't know, I can't really see myself when it happens." And she was like "are you willing to experiment with this a little?" And I was like "sure, no worries" and she injected me with one anesthetic and it hurt like a motherfucker and she and the assistant both went "OOOH" and she was like "Yeah you got really red right away let's try the other," and it was the same thing and then she was like "okay I think this is the one that will work" and it hurt a little bit but it was fucking NOTHING compared to the comprehensive full stabbing burning facial pain from the others and long story short the dentist was like "You're reacting to the epinephrine in these other anesthetics," which I guess is fairly common for people who have autoimmune disorders.

So I guess this is to say: If you get spreading, burning, stabbing pain when you are being injected with local anesthetics it's not supposed to do that and you should say something.

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[tornadoauction]

Listen/purchase: Lidocaine by Nicholas

Dreaming of Tokyo Kissing on Hollywood Boulevard is good for the soul Go to the beach and let all of our worries go Look at the water and listen to books on audio Slow and steady, lidocaine Sweat and heady, summer rain All my life I promise babe I waited for you to come Take me in tidal wave The water is freezing, the sky is grey All my life, I promise babe I waited for you to come Nobody’s perfect, Charlie Brown I cried on a train headed downtown Kintsugi is how I unbreak my heart Pacific volcanoes erupt in the dark Slow and steady, lidocaine Sweat and heady, summer rain All my life I promise babe I waited for you to come Take me in tidal wave The water is freezing, the sky is grey All my life, I promise babe I waited for you to come Durian rush I don’t wanna feel afraid And give up before I get to the good stuff Slow and steady, lidocaine Sweat and heady, summer rain All my life I promise babe I waited for you to come Take me in tidal wave The water is freezing, the sky is grey All my life, I promise babe I waited for you to come Durian rush I don’t wanna feel afraid And give up before I get to the good stuff Durian rush I don't want to feel afraid...

[metropolitandentalbrooklyn]

Can I Use Lidocaine for Braces Pain? Metropolitan Dental Arts Brooklyn Weighs In

[loversplayground]

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