#Human Kidney

[arogyadhamr]

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[crabs-brencil]

his mental dialogue when he's in the field is just a mess of "ops eliminated" "i am executing so hard rn" and "ace" you cannot convince me otherwise

[reasonsforhope]

"For the first time, genetically modified pig kidneys provided “life-sustaining kidney function” during the course of a planned seven-day clinical study—a first step in addressing the critical crisis worldwide of kidney donor organ shortage.

The University of Alabama’s pre-clinical human study at Birmingham also advances the science and promise of xenotransplantation as a therapy to potentially cure end-stage kidney disease—just as a human-to-human transplants can.

“It has been truly extraordinary to see the first-ever preclinical demonstration that appropriately modified pig kidneys can provide normal, life-sustaining kidney function in a human safely and be achieved using a standard immunosuppression regimen,” said UAB transplant surgeon scientist Jayme Locke, M.D., director of UAB’s Comprehensive Transplant Institute and lead author of the paper...

The peer-reviewed findings published last month in JAMA Surgery describes the pioneering pre-clinical human research performed on a recipient experiencing brain death...

The pre-clinical human brain death model developed at UAB can evaluate the safety and feasibility of pig-to-human kidney xenografts, or transplants, without risk to a living human. It is named for transplant pioneer Jim Parsons, an organ donor whose family generously donated his body to advance xenotransplant kidney research, like the latest patient did.

A Critical Need

Kidney disease kills more people each year than breast or prostate cancer, while more than 90,000 people are on the transplant waiting list. More than 800,000 Americans are living with kidney failure and 240 Americans on dialysis die every day. The wait for a deceased donor kidney can be as long as five to 10 years, and almost 5,000 people per year die waiting for a kidney transplant.

Groundbreaking Study Details

The 52-year-old study subject for this research lived with hypertension and stage 2 chronic kidney disease, which affects more than one in seven U.S. adults, or an estimated 37 million Americans. As part of this study, the subject had both of his native kidneys removed and dialysis stopped, followed by a crossmatch-compatible xenotransplant with two 10 gene-edited pig kidneys, or UKidney.

The transplanted pig kidneys made urine within four minutes of re-perfusion and produced more than 37 liters of urine in the first 24 hours. The pig kidneys continued to function as they would in a living human for the entirety of the seven-day study. Also, the kidneys were still viable at the time the study was concluded.

“In the first 24 hours these kidneys made over 37 liters of urine,” said Dr. Locke. “It was really a remarkable thing to see.” ...

Gene editing in pigs to reduce immune rejection has made organ transplants from pigs to humans possible. The natural lifespan of a pig is 30 years, they are easily bred, and they have organs of similar size to humans. Genetically modified pig kidneys have been extensively tested in non-human primates, and the addition of UAB’s preclinical human research model—the Parsons Model—now provides important information about the safety and efficacy of kidneys in human transplant recipients."

-via Good News Network, September 17, 2023

[victimized-martyr]

ur making me wanna ship kyman (only if cartman gets therapy) what the actual fuck is Tumblr doing to me

Nice to tempt you to the dark side 👻

lolol in all seriousness, that’s cool! Technically, Cartman *is* in therapy. He’s seeing Thomas (Panderverse), remember? And it’s strongly implied he’s on medication (Cupid Ye). Can’t say if he’s getting better or worse, but Cartman definitely has evolved. If you want to go the redemption route, it’s been shown that it takes little for Cartman to be “fixed”. He just needs discipline, a sturdy male figure in his life. He… needs to be dominated. Literally (tsst) and if not that, he needs to get out of South Park— his biggest enabler. So, he’s not too far gone. He’s a real piece of work though, and South Park’s wellbeing (in-show and out) can’t function without him being an asshole. It’s just who he is. But whoever decides to stick with him has to have a lot of determination to deal some damage control, or keep him in check. (hm, sounds familiar…)

So, there’s your condition met. Go forth and ship kyman! 🫡

[the-trueantichrist-666]

the Thing i Like most about ronin Is That despite obviously being a Deeply Immoral person he Has a redemptive Side To him. it would have Been Easy for the writer to Write Him as Just a 2d edgelord-Bait character but instead He Does actually have like depth to Him and a sympathetic Reason Why he is the Way He is.

[bitchfitch]

tbh I'm never going to stop being mad about the Manx syndrome that makes Manx cats manxes. It's an easily, Visually identifiable trait that causes the afflicted animal life long discomfort and mobility issues so severe many need specialized care and equipment to give them a normal life. And that isnt even taking into account how many die as kittens or who need to be put down because they'll never have the minimum quality of life needed to subject them to their difficulties.

there's 2 genes that can cause shortened tails/no tail in cats and while it's debatable how ethical the other one is, due to how important tails are for cat communication, the bobtail Gene is at least not devastating to the animals welfare. Unlike Manx syndrome it just causes the kittens to be born with fewer tail vertebrae. All the other vertebrae are unaffected.

Manx syndrome, in the more severe cases, which to be clear are the breed standard and are considered Desirable, cause the back half of the spine to fail to form correctly. This causes the cats to "hop like bunnies" bc their hind legs are partially paralyzed. they have severe nerve issues bc their spinal cord isn't fully encased in bone like it should be. The paralysis effects their guts too, making many of them incontinent or unable to relieve themselves properly. which leads to chronic UTIs and them needing frequent baths. which, they are cats, they do not like baths.

The main defense of the continued intentional breeding of manxes is that it is a naturally occurring mutation, as in its a landrace breed that initially happened on its own in the feral cat population on the island of mann. "if they were able to survive and reproduce under those conditions then surely it's ok" type of argument. A dominant trait spreading through a feral cat population on a small island that has no predators and plenty of small animal prey to eat, is not a defense. it's the law of large numbers.

[eternal-moss]

Falin panel in my style

:D I suddenly felt compelled to redraw the panel. Miss Touden you are my muse

Lineart + original panel under the cut

I mean, look at the improvement from one drawing to the other, Ryoko Kui’s art makes me think hard about anatomy + physics and it feels really good to draw :3

\/ original panel!

[wr1t3w1tm3]

Question: why can't Broadway musicals tape their performance and put it up on a platform for rental while the shows still on Broadway?

Obviously you charge a fair price for the rental, make it like 48 hours and cost maybe whatever their general admission ticket costs. Then, after the musical comes off Broadway, you make that original cast recording avaliable to buy permanently (like including downloads) for that general admission ticket price and knock down the rental price.

Now you'd have to either come up with a streaming service or license it out to one which is not ideal, but it would vastly improve the availability of musical theater especially to people who live outside of New England or people who don't have thousands of dollars to drop just to go see a musical. Not to mention it could help make newer musicals more accessible and easily spread, and don't get me started on accessibility especially when it comes to physical disabilities that would disallow travel or actually seeing a musical in person. This would also allow people to see the musical and then maybe go watch it in person, which increases revenue.

It also allows a continuous revenue stream for the creative team and possibly actors (depending on how contracts are structured), particularly in cases of musicals with specific historical or literary settings that could be used in classrooms (think Hamilton, West Side Story, Fiddler on the Roof, the upcoming The Outsiders, or like every Shakespear play ever). Or even if a musical is really popular and gets a cult following like 30 years later, it would be available in a watchable format and not just as a soundtrack. Plus it'd get rid of people going to musicals for the sole purpose of uploading a slime tutorial.

[coockie8]

i saw that post about roy smoking pot and i raise you the headcanon i have that ed uses weed as a way to self-medicate with the chronic pain brought on by his automail ^^ and also recreationally because he's a little punk and thinks its fun as well as helpful

Ed's stunned for like 0.2 seconds upon finding out that Roy is also low key a pot head, until rapidly getting excited to finally have someone to get high with haha

The alchemic theories these two would come up with while stoned together though lmao

[lorainedoesthings]

Crack YIAU thoughts featuring my bilingual brain & two idiots (context in the tags!)

(aka me & @thatcheeseycandle )

GC is literally dedicated to theories and other stuff relating to YIAU.

[dudukbazaar]

Urinary tract Value ●●●●○ ; Size ●●○○○ The base is often moist. It is mostly used for a kidney or two, rarely the stems.

[2129888]

higuchi sensei when it's time to cook up the guy that'll be falling in love with the main character in one of her little stories

[hottakehoulihan]

Cauldron powers are sick imagine a caterpillar sipping part of a human's brain and kidney juices and generating force thumbs or the ability to seed clouds or a capability to send mutant ladybugs on violent errands.

[chicago-geniza]

Idk what my kidneys are doing but I finally took enough diuretics to get the swelling down somewhat. I need to be juiced like a lemon

[ivan-fyodorovich-k]

I would really like it if the hive mind could move away from the idea that the exception disproves the rule every time

there's such a thing as statistical distribution, the species is made up of unique individuals that nevertheless aggregate into identifiable trends, you can have something be true of most or virtually all people and nevertheless find exceptions. This runs the gamut from effective medical treatments, to the kinds of media people like, to gender roles and expressions, all kinds of things

This Procrustean effort to force everyone to conform to the standard and/or the delusion that the standard is just an axiomatic lie that can be tossed out on a whim are both ridiculous, you can have rules of thumb and broad heuristics that allow for all kinds of exceptions without being falsehoods

[the-trueantichrist-666]

this Has absolutely Zero Relevance to anything else I Have Posted i just wanted to make a hazbin Shitpost

Seriously Why did he lose His Melanin as soon as he got to hell?