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hallmark-movie-fanatics · 1 year ago
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See first photos of 42 new Hallmark Christmas movies (Entertainment Weekly) - Hallmark Channel Part 1
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Checkin' it Twice Premieres: Oct. 20, 8 p.m. ET/PT, Hallmark Channel Cast: Kim Matula, Kevin McGarry Contains: Ice sports, new neighbors Official description: "A journeyman hockey player (McGarry) falls for a real estate agent (Matula) in a career crisis when he's traded to her hometown and moves into the cottage in her hockey loving family's backyard."
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Where Are You, Christmas? Premieres: Oct. 21, 8 p.m. ET/PT, Hallmark Channel Cast: Lyndsy Fonseca, Michael Rady, Jim O'Heir, Julie Warner Contains: A sprinkle of holiday magic, unexpected consequences, Garry Jerry Lenny Larry Terry Gergich Official description: "Addy (Fonseca) wishes for a year without Christmas and she wakes up in a world of black and white. She must work together with the town mechanic (Rady) to restore Christmas."
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Under the Christmas Sky Premieres: Oct. 22, 8 p.m. ET/PT, Hallmark Channel Cast: Jessica Parker Kennedy, Ryan Paevey Contains: A life-altering accident, an out-of-this-world romance Official description: "Kat (Kennedy) is an esteemed astrophysicist, who is scheduled for her first trip into space next year until an accident grounds her.  While on leave, coming to terms with the reality that her dream of being an astronaut is over, she volunteers at the local planetarium.  There, she is paired up with by-the-book David (Paevey) to work on an exhibit opening right before Christmas. Will the stars align to bring these two together at the holidays?"
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Christmas By Design  Premieres: Oct. 27, 8 p.m. ET/PT, Hallmark Channel Cast: Rebecca Dalton, Jonathan Keltz Contains: Christmas couture, learning what matters most Official description: "A fashion designer (Dalton) gets accepted into a Christmas challenge to create a new holiday-themed collection and not only finds the inspiration for her next line but decides to redesign her approach to what's most important in life."
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Mystic Christmas Premieres: Oct. 28, 8 p.m. ET/PT, Hallmark Channel Cast: Jessy Schram, Chandler Massey, Patti Murin, William R. Moses Contains: Mystic Pizza-adjacent, fish friends, Mystic, Conn.  Official description: "Juniper (Schram) travels to Mystic, Connecticut during the holidays to work at the rehabilitation center and aquarium. She reconnects with Sawyer (Massey), the owner of the pizza shop."
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Joyeux Noel Premieres: Oct. 29, 8 p.m. ET/PT, Hallmark Channel Cast: Jaicy Elliot, Brant Daugherty Contains: France, a mysterious artist, an editor and reporter on the case  Official description: "When a romantic painting of a Christmas market captures the imagination of copy editor Lea (Elliot), she is sent to France with pragmatic reporter Mark (Daugherty) to uncover the mystery behind the artist."
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Flipping for Christmas Premieres: Nov. 3, 8 p.m. ET/PT, Hallmark Channel Cast: Ashley Newbrough, Marcus Rosner Contains: Real estate agents, a supposedly simple house renovation Official description: "It's almost Christmas when busy realtor Abigail (Newbrough) agrees to help her sister with the 'simple flip' of a recently inherited home. Unfortunately, co-beneficiary Bo (Rosner) has other plans in mind."
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Never Been Chris'd Premieres: Nov. 4, 8 p.m. ET/PT, Hallmark Channel Cast: Janel Parrish, Pascal Lamothe-Kipnes, Tyler Hynes Contains: Reunited BFFs, a reignited high school love triangle  Official description: "Home for the holidays, BFFs Naomi (Parrish) and Liz (Lamothe-Kipnes) reconnect with high school crush Chris Silver (Hynes). A complex love triangle forms, forcing them to take stock of their lives and find the value of friendship."
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The Santa Summit Premieres: Nov. 5, 8 p.m. ET/PT, Hallmark Channel Cast: Hunter King, Benjamin Hollingsworth, Amy Groening, Stephanie Sy Contains: A Santa convention, chasing down a lost Claus  Official description: "Jordin (King), Ava (Groening) and Stella (Sy) are three best friends who head out for a night on the town to take part in the annual Santa Summit, an event where revelers don Santa suits and visit local spots on the circuit to eat, drink and be merry in true holiday fashion… and set out to find a secret Santa (Hollingsworth) Jordin connected with at the start of the night's festivities."
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Everything Christmas Premieres: Nov. 10, 8 p.m. ET/PT, Hallmark Channel Cast: Katherine Barrell, Cindy Busby, Corey Sevier, Matt Wells Contains: Holiday road trip, unforeseen circumstances Official description: "Lori Jo's (Busby) love for Christmas takes her on a road trip to Yuletide Springs with her roommate Tori (Barrell), where Christmas is celebrated year-round, to participate in a longstanding town tradition to honor her late grandmother.  Along the way, the friends meet Carl (Sevier) and Jason (Wells), and the foursome make stops during their journey to enjoy more small-town Christmas attractions. But when a series of events puts a damper on their plans, a little Christmas magic may put this trip back on the right path."
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Christmas Island Premieres: Nov. 11, 8 p.m. ET/PT, Hallmark Channel Cast: Rachel Skarsten, Andrew Walker Contains: Inclement weather, a career on the line Official description: "When a snowstorm diverts Kate's (Skarsten) first private flight en route to Switzerland to Christmas Island, she must team up with an air traffic controller (Walker) to secure her dream job as the family's pilot."
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A Heidelberg Holiday  Premieres: Nov. 12, 8 p.m. ET/PT, Hallmark Channel Cast: Ginna Claire Mason, Frédéric Brossier  Contains: Germany, a holiday market, getting in touch with one's roots  Official description: "Heidi Heidelberg (Mason) receives the dream opportunity to sell her beautiful, handmade glass ornaments at the prestigious Heidelberg Christmas Market in Germany. While there, she meets Lukas (Brossier), a local artisan who helps her reconnect with her lost heritage."
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Navigating Christmas Premieres: Nov. 17, 8 p.m. ET/PT, Hallmark Channel Cast: Chelsea Hobbs, Stephen Huszar Contains: A divorcée, ringing in the holidays on a remote island, a hot lighthouse operator Official description: "Recently divorced Melanie (Hobbs) and her son Jason visit a remote island for Christmas, only to find themselves running a real working lighthouse where she connects with the curt but cute owner (Huszar)."
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A Merry Scottish Christmas Premieres: Nov. 18, 8 p.m. ET/PT, Hallmark Channel Cast: Lacey Chabert, Scott Wolf Contains: A Party of Five reunion, a brother-and-sister duo, Scotland, hidden secrets Official description: "When estranged siblings, Lindsay (Chabert) and Brad (Wolf) Morgan travel to Scotland at Christmas to reunite with their mother Jo, a big family secret is revealed."
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Holiday Hotline Premieres: Nov. 19, 8 p.m. ET/PT, Hallmark Channel Cast: Emily Tennant, Niall Matter Contains: London, love at first phone call, a secret connection Official description: "After leaving London, Abby (Tennant) connects with an anonymous caller while working at a cooking hotline. The caller is single dad 'John' (Matter) who Abby unknowingly has become smitten with in real life."
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Catch Me If You Claus Premieres: Nov. 23, 8 p.m. ET/PT, Hallmark Channel Cast: Italia Ricci, Luke Macfarlane Contains: An ambitious news anchor, a home intruder purporting to be Santa's son, a high-stakes Christmas caper Official description: "Avery Quinn (Ricci) is an aspiring news anchor who's finally getting her big break on her station's Christmas morning newscast. But that's put in jeopardy when she captures an intruder in her home wearing a red suit claiming to be Chris (Macfarlane), Santa's son, who is on his first mission. A night of adventure ensues as they find themselves being pursued by the police as well as some shady characters. Along the way, they connect over living in the shadow of their parents and inspire each other to go after their dreams."
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Letters to Santa Premieres: Nov. 24, 8 p.m. ET/PT, Hallmark Channel Cast: Katie Leclerc, Rafael de la Fuente Contains: A wish-granting pen, children of divorce Official description: "When young siblings receive a magic pen from Santa that appears to be granting wishes, they request a Christmas gift they want more than anything – for their separated parents (Leclerc, de la Fuente) to reunite."
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Holiday Road Premieres: Nov. 24, 8 p.m. ET/PT, Hallmark Channel Cast: Warren Christie, Sara Canning Contains: Inspired by real events, canceled flights, unexpected allies, holiday road trip Official description: "When bad weather leaves each of them stranded at the airport for the holidays, a tech entrepreneur (Christie), a travel writer (Canning), a devoted mother (Enid-Raye Adams) and her son (Kiefer O'Reilly), a stubborn senior (Trevor Lerner), an enigmatic woman with a hint of mystery (Brittany Willacy), a couple traveling from Beijing (Sharon Crandall, Ryan Mah) and a social media influencer (Princess Davis) all agree to rent a shared van to embark on a road trip to Denver. When their unexpected journey brings them into uncharted territory, they navigate a series of misadventures together and form a deeper bond that just might change the trajectories of each of their lives. Inspired by true events."
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Christmas in Notting Hill Premieres: Nov. 25, 6 p.m. ET/PT, Hallmark Channel Cast: Sarah Ramos, William Moseley  Contains: Haddie Braverman and Peter Pevensie, London, a famous footballer, an American on holiday  Official description: "Famous soccer star, Graham Savoy (Moseley), has always been too busy for love, but when he comes home to Notting Hill for Christmas, he changes his mind after meeting Georgia (Ramos) – a visiting American and the one person who has no idea who he is."
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Haul Out the Holly: Lit Up Premieres: Nov. 25, 8 p.m. ET/PT, Hallmark Channel Cast: Lacey Chabert, Wes Brown, Stephen Tobolowsky, Melissa Peterman, Ellen Travolta, Seth Morris, Jennifer Aspen Contains: A sequel, new neighbors, lots and lots of holiday decorations Official description: "As the holidays approach, Emily (Chabert) and Jared (Brown) are looking forward to celebrating the holidays together again, this time as a couple. Emily, now embracing Evergreen Lane's uniquely festive spirit, is ready to work with Jared, Ned (Tobolowsky), Mary Louise (Travolta) and Pamela (Peterman) to make this year's Christmas celebrations the best yet – even if being the HOA president's girlfriend doesn't stop those dreaded decorating citations.  When a house on the block goes up for sale, it causes quite a stir with residents.  When the soon-to-be neighbors turn out to be holiday royalty (Morris, Aspen), it looks like this year's competition is about to heat up. As the welcoming committee prepares for the new arrivals, only one thing is certain – this Christmas, Evergreen Lane is going to sleigh!"
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Our Christmas Mural Premieres: Nov. 26, 6 p.m. ET/PT, Hallmark Channel Cast: Alex Paxton-Beesley, Dan Jeannotte Contains: Home for the holidays, single mother, a holiday art contest Official description: "Olivia (Paxton-Beesley) is a single mom who returns home for Christmas. Her mom secretly enters her into a mural contest; she wins but partners with teacher Will (Jeannotte) to create a Christmas masterpiece."
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A Biltmore Christmas Premieres: Nov. 26, 8 p.m. ET/PT, Hallmark Channel Cast: Bethany Joy Lenz, Kristoffer Polaha, Jonathan Frakes, Robert Picardo Contains: Star Trek and One Tree Hill stars, the Biltmore Estate, a screenwriter penning a classic holiday film reboot, time travel, a 1940s film star, a time paradox Official description: "Lucy Hardgrove (Lenz) is a screenwriter who lands the job of a lifetime when she's hired to pen the script for a remake of the beloved, holiday movie classic, His Merry Wife!, which was filmed in 1947 at the beautiful, historic Biltmore House. When the head of the studio isn't satisfied with the ending Lucy wrote because it deviates from the original's feel-good conclusion, he sends Lucy to Biltmore Estate for research and inspiration. While there, she unwittingly discovers the ability to travel to the 1947 set of His Merry Wife! through the help of an hourglass. While on set, she and Jack Huston (Polaha), one of the film's stars, spend time together and become close. But her sudden appearance has set off a chain of events that put the production in jeopardy. Before she can return to the present, Lucy must make things right or threaten to alter the future forever."
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My Norwegian Holiday Premieres: Dec. 1, 8 p.m. ET/PT, Hallmark Channel Cast: Rhiannon Fish, David Elsendoorn Contains: Christmas in Norway, a mysterious connection, troll history Official description: "JJ (Fish), grieving the loss of her grandmother and seeking dissertation inspiration, stumbles upon an unexpected holiday destiny. Meeting Henrik (Elsendoorn), a Norwegian from Bergen, their connection deepens when he discovers she has a troll figurine from his hometown. To explore the troll's history and her grandmother's ties, JJ agrees to join Henrik on a journey to Norway. In Bergen, they're drawn into Henrik's family Christmas and wedding traditions, with his sister's wedding the day before Christmas Eve. JJ embarks on a holiday adventure, uncovering the troll's origins and finding her own path to healing, love and family."
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A Not So Royal Christmas Premieres: Dec. 2, 8 p.m. ET/PT, Hallmark Channel Cast: Brooke D'Orsay, Will Kemp Contains: A journalist tracking down a story, a hidden identity, missing royalty Official description: "Tabloid journalist Charlotte (D'Orsay) attempts to land an interview with a reclusive Count. In response, the royal family has a groundskeeper (Kemp) pose as the Count since the real one fled years ago."
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Christmas With a Kiss (working title) Premieres: Dec. 3, 8 p.m. ET/PT, Hallmark Channel Cast: Mishael Morgan, Ronnie Rowe Jr., and Jaime M. Callica Contains: Home for the holidays, a family-run Christmas carnival Official description: "A Mahogany presentation. A woman (Morgan) returns home to help with her family's Christmas Carnival and romance ignites. A photojournalist (Rowe) curates a surprise reunion."
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Magic in Mistletoe Premieres: Dec. 8, 8 p.m. ET/PT, Hallmark Channel Cast: Lyndie Greenwood, Paul Campbell Contains: A curmudgeonly author who sparks backlash online, his well-meaning publicist, and a Christmas festival  Official description: "Harrington (Campbell) is the author of a popular book series but commercial success has left him a bitter recluse. As he returns to his hometown for an annual Christmas festival celebrating his books, he's joined by April (Greenwood), a publicist for the major publishing house he works with.  April is there for damage control after Harrington's recent comments on social media have ruffled some feathers. But as she gets to know him better, hope springs that April can unlock Harrington's guarded heart and help him rediscover the spirit of the holiday."
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Christmas on Cherry Lane Premieres: Dec. 9, 8 p.m. ET/PT, Hallmark Channel Cast: Catherine Bell, Jonathan Bennett, John Brotherton, Erin Cahill, James Denton, Vincent Rodriguez III Contains: Aaron Samuels, a neighborhood coming together for the holidays Official description: "A young couple preparing to welcome their first child (Brotherton, Cahill); an empty-nester (Bell) and her fiancé (Denton) ready to start a new chapter; and a couple (Bennett, Rodgriquez III) who unexpectedly have the chance to expand their family on Christmas Eve celebrate the holiday as they navigate these turning points in their lives."
Click these links for more, ew.com, today.com, tvinsider.com
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larryland · 4 years ago
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REVIEW: "Church & State" at Berkshire Theatre Group
REVIEW: “Church & State” at Berkshire Theatre Group
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tenshichan1013 · 5 years ago
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squad goals
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papermoonstheatricaldiary · 8 years ago
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THE IMPORTANCE OF BEING EARNEST
January 16, 2009
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THE IMPORTANCE OF BEING EARNEST (subtitled A Serious Comedy for Trivial People) is a three act comedy of manners by Oscar Wilde. The story: Two wealthy young gentlemen have taken to bending the truth in order to put some excitement into their lives. Bachelor Jack Worthing has invented a brother, Ernest, who he uses as an excuse to leave his dull country life to visit the beautiful young Gwendolyn. Algernon Moncrieff decides to take the name Ernest when visiting Worthing's young and beautiful ward, Cecily. Things start to go awry when they all end up together in the country, and their deceptions are discovered by the persistent inquiries of the imperious Lady Bracknell.
It was first performed on Valentine's Day 1895 in London, England.  The play was first performed in New York that same year, and has been seen on Broadway eight times since, the last being in 2011. The play has been seen on screens (big and small) many times, the most famous being in 1952 (starring Michael Redgrave, father of Lynn and Vanessa) and the most recent 2002 (starring Colin Firth).  The play is in constant production in regional (see below), educational, and community venues.  
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THE IMPORTANCE OF BEING EARNEST was produced by New Jersey's Paper Mill Playhouse (Millburn) from January 14 to February 15, 2009.  It was directed by David Schweizer with costumes by David Murin and scenery by Alexander Dodge.  It starred John Wayne Wilcox (Jack), Jeffrey Carlson (Algernon), Keith Reddin (Rev. Chausuble), Chris Spencer Wells (Merriman / Oscar Wilde), Lynn Redgrave (Lady Bracknell), Annika Boras (Gwendolyn), Zoe Winters (Cecily), Cynthia Mace (Miss Prism), and Justin Bellero and Matthew Capodicasa as Footmen.  
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In the pantheon of English theatre, Hamlet is generally considered to be the finest tragedy ever written, and EARNEST the best comedy.  The fact that both are in constant production is testament to those somewhat immeasurable assessments.  Although Paper Mill Playhouse is not known for producing the 'classiscs' – this century old audience pleaser is one that entertains everyone and stands up to multiple viewings. This production added some wild(e) new elements, including the playwright himself observing the show from a theatre box, sipping champagne and (oddly) making the 'cell phone speech (”Whatever those are!”)  The production eliminated one of the intermissions of the three-act, three-set comedy, forcing the set design Alexander Dodge to create a clever set that could entertainingly transform from London flat to Manor House Garden in front of the audiences eyes.  It worked!  The first act was monochrome, the second verdant greens, and the third reds and blacks. Wow!  The costumes were pretty outrageous but had their logic and followed the color scheme of the scenery.  
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Despite all this diversion, the real star of this show was its real star – Miss Lynn Redgrave.  There's something to say for having genuine English Theatre royalty playing the English Theatre's most cherished character role – Lady Augusta Bracknell.  It is also more poignant that her father starred in the most famous film adaptation of the play.  Not only was Lynn Redgrave glorious on stage, she was one of the loveliest actors ever to pass through the Millburn stage doors.  And I don't say this because she sadly died just a year after EARNEST.  It was just as true from the time she left the building to the time she left this earth.  While her sister has a sterner reputation, Lynn exuded generosity and love.  Although I wasn't there that night, Vanessa did come to Paper Mill to see her sister perform, testament to their sibling bond.   Although there have been many EARNESTs since 2009, this one was memorable – if for nothing other than Miss Lynn Redgrave.   
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THE IMPORTANCE OF BEING EARNEST rates 4 Paper Moons out of 5
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bpod-bpod · 3 years ago
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Passing on Plague
Yersinia pestis picked up several tricks. One is yersinia murine toxin (Ymt), a protein that helps it colonise the gut of fleas, its vectors between mammal hosts. Pictured are sections of flea guts, showing the thin oesophagus connecting to the larger midgut, after they were fed blood containing mutant Y. pestis, lacking Ymt. If acquired from mouse (top panels) or human blood, these bacteria struggle to take hold and are quickly eliminated. By contrast, when ingested with brown rat blood (below), which fleas take longer to digest, Y. pestis can persist even in the absence of Ymt. Variation between species suggests ancient strains lacking Ymt could already use fleas to move between certain hosts. Gaining Ymt then opened the door to much greater flea-borne transmission, between more species, highlighting how genetic innovations can alter the course of disease history.
Written by Emmanuelle Briolat
Image adapted from work by David M. Bland and colleagues
Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT, USA
Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
Published in PLOS Pathogens, October 2021
You can also follow BPoD on Instagram, Twitter and Facebook
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redrumluna · 4 years ago
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Broadway & Accesibility
Written by L. Musch
 Broadway in NYC consists of 40 theaters that are visited by over 12 million audience members annually. 80% of all tickets in the 2014–2015 season were purchased by caucasian theatregoers. The average age of the Broadway theatregoer in the 2019–2020 season was 42.3 years old and the average household income of these audience members was $261,000, much higher than the U.S national average of $87,863. The average price of a ticket for a Broadway show has been reported to be $145.60 per ticket. In other words, these audiences are, mostly, old, rich and white. In this essay I’m gonna discuss how social media has been revolutionizing Broadway and the theatre experience over the past few years.
 On january 10th, 2009, the Broadway revival of the musical GYPSY was ending it’s run at the St. James Theatre. Broadway icon Patti LuPone (who won her second Tony award for her performance in this production) noticed several camera flashes coming from the audience, causing her to almost trip twice. When another flash went off she stopped the show to yell at the audience member taking pictures and had them kicked out. After that she continued her performance. While this event was happening another audience member made an illegal audio recording from this performance. The recording ended up on YouTube and the rant went viral. 
Due to the lack of accesibility surrounding Broadway, there’s a huge demand for illegal footage of performances, which is why bootlegs (illegal recordings of Broadway shows) are the perfect solution for fans who wouldn’t be able to experience the shows in person. To fans, bootlegs give the complete picture of the Broadway experience. It includes the parts of the show that aren’t in the official cast recordings, which can be important, because often just hearing lyrics and music cannot justify the plotholes between the songs. Bootlegs give fans all over the world an understanding of the show, even if it’s recorded with a low quality phone and another audience member’s head is in frame for most of the video. 
Although many theatre people, including actors such as Patti Murin (Anna in Frozen the musical), believe that bootlegs will destroy Broadway forever. Because they believe that people will stop paying for the shows since they can see them online for free.
 Personally, I believe this is a very privileged way of thinking. The fans that watch, post and trade these bootlegs are mostly teenagers. Teenagers who constantly tweet about their favourite broadway shows, who stream these cast recordings on spotify and who get shows that are currently on Broadway trending on apps like TikTok.
 I’d like to use the Broadway hit Hamilton as an example. When the show started it’s run on Broadway it didn’t take long for it to become huge on social media, teenagers quickly started an online fan community on sites like Twitter and Tumblr and the soundtrack was everywhere. Hamilton bootlegs on YouTube got the most views out of all of them, yet it was the second-highest-grossing show (behind only The Lion King). The show set a Broadway box office record for the most money grossed in a single week in New York City in late november 2016, when it grossed $3.3 million for an eight-performance week. the first show to break $3 million in eight performances.
I also believe Hamilton’s online succes has a lot to do with it’s creator and lead Lin-Manuel Miranda being very active on Twitter and engaging with young fans, posting loads of backstage content and answering many questions about the show. Another show that has gained a lot of attention because of social media is Beetlejuice the musical. Presley Ryan (Former ensemble member and now currently starring as Lydia Deetz in the show) started sharing videos of her and other cast members on the app TikTok. Beetlejuice didn’t do very well in the first weeks of it’s run, but became a huge hit when the soundtrack started going viral online.
 “TikTok was a game changer for Beetlejuice because it allowed our original cast recording to reach millions more young people than Broadway marketing campaigns usually allow,” explains Jennifer Graessle, social media manager for the musical. Graessle believes the musical’s songs work well on TikTok because of their quick, quirky lyrics. The success on TikTok has helped drive 150 million streams for the cast recording, “and its popularity, both on TikTok and beyond, has had a residual effect on the show’s social media presence and ticket sales,” she says. It’s also been a savior for the show — even if it’s being kicked out of New York’s Winter Garden Theater, to be replaced by a revival of The Music Man. Initial reaction towards the production when it launched on Broadway in October 2018 was muted. “I think that word of mouth is what has saved the show from the initial critics of the show who are from an older generation and maybe just didn’t ‘get us’,” says Ryan.
 An alternative for bootlegs could be streaming services. There is currently one named Broadway HD. For $8,99 a month you can watch proshots of a limited collection of Broadway plays and musicals. Hopefully the streaming service will continue to broaden their collection and open up a whole new world for anyone at home or unable to travel to NYC.
 During the recent pandemic there have also been many livestreams of shows that aren’t currently running anymore, like the recent stream of David Bowie’s Lazarus, which was recorded live in 2016 and streamed earlier this month in honor of the icon’s birthday.
 So obviously, the theatre industry has been taking steps to broaden the representation of the performing arts on the internet. Despite the fact that we are far from truly accesible Broadway content i do believe that it will eventually evolve to be that. Theatre people are realizing that the public wants to pay for proshots or streams.
 I believe that accesibility will create more appreciation for the arts and therefore save Broadway.
Resources used: Research Reports | The Broadway League (6) Patti Lupone stops 'Gypsy' mid-show to yell at a photographer - YouTube (3) Patti Murin on Twitter: "No, because then Broadway will never come back" / Twitter Hamilton (musical) - Wikipedia Presley Ryan’s TikToks Have Made Beetlejuice Broadway’s Hottest Ticket | by Chris Stokel-Walker | FFWD (medium.com) BroadwayHD David Bowie's 'Lazarus': London Production Livestreams of Musical - Rolling Stone
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hurtworld · 4 years ago
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mesaj attım ama cevap vermedin dostum. PCR ve qPCR teknikleriyle alakalı kaynak olarak yardımcı olabilir misin?
mendeley kullanıyor musun bilmiyorum ama ben APA şeklinde buraya atayım kaynakları sen seç beğen al dostum.
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telmmas · 5 years ago
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Ученые узнали, какие продукты вызывают рак простаты
High-fat diet proven to fuel prostate cancer progression by imitating a key cancer alteration
What molecular event happens for prostate cancer to progress faster and to be deadlier when patients eat a high-fat diet? This is the question Dr. David P. Labbé, a scientist at the Research Institute of the McGill University Health Centre (RI-MUHC), and his colleagues recently elucidated. In a study published in Nature Communications, they showed that saturated fat intake induces a cellular reprogramming that is associated with prostate cancer progression and lethality. These findings could have a clinical utility in identifying patients at higher risk of a more aggressive, lethal disease. In addition, they suggest that dietary intervention involving the reduction of animal fat, and specifically saturated fat consumption in men with early-stage prostate cancer, could possibly diminish or delay the risk of disease progression.
Some genes—called oncogenes—play a role in cancer initiation and progression. MYC is one of those.
«In this paper, we showed that by mimicking a MYC overexpression, saturated fat intake makes prostate cancer worse,» says Dr. Labbé, who started this study at the Dana-Farber Cancer Institute in the United States, under the supervision of Dr. Myles A. Brown, Director of the Center for Functional Cancer Epigenetics and Emil Frei III Professor of Medicine at Harvard Medical School.
«MYC overexpression profoundly rewires cellular programs and bolsters a distinctive transcriptional signature. MYC is a key factor in tumorigenesis, i.e. it induces malignant properties in normal cells and fuels the growth of cancer cells,» adds Dr. Labbé, who is also assistant professor in the Department of Surgery, Division of Urology at McGill University.
Based on answers to validated food frequency questionnaires obtained from the Health Professionals Follow-Up Study and the Physician Health Study cohorts, researchers were able to stratify prostate cancer patients based on their fat intake—high-fat diet vs. low-fat diet—and the type of fat they were eating—either saturated, monounsaturated or polyunsaturated fat. By integrating dietary and gene expression data from 319 patients, researchers discovered that animal fat and specifically saturated fat consumption mimicked a MYC overexpression. They validated their findings in vivo using a murine prostate cancer model.
Strikingly, patients who had the highest level of the saturated fat intake (SFI) MYC signature were four times more likely to die from prostate cancer, compared to patients with the lowest level, independently of the patient’s age or year at diagnosis. Even after adjusting the results for cancer Gleason grade—an indicator of the aggressiveness of the disease—this association remained significative.
Since fat consumption could be linked to an increase in body fat and obesity, and since obesity is also a risk factor associated with prostate cancer, Dr. Labbé used the Body Mass Index (BMI) to make sure that it was only saturated fat intake—and not obesity—that promoted the progression to a metastatic and lethal disease.
«Even after removing obesity from the equation, patients with high levels of the SFI-MYC signature are still three times more likely to die of prostate cancer,» says Dr. Labbé. «Epidemiological studies have previously reported that saturated fat intake is associated with prostate cancer progression. Our study provides a mechanistic underpinning to this link and a basis to develop clinical tools aimed at reducing the consumption of saturated fat and increasing the odds of surviving.»
The study also showed that for saturated fat to induce MYC reprogramming, the tissue needs to be transformed.
«In a prostate cancer patient, the prostate contains both tumour and normal tissue,» explains Dr. Labbé. «We showed that saturated fat intake only affects the transcriptional program in the tumour tissue.»
«Altogether, our findings suggest that a substantial subset of prostate cancer patients, including some without MYC amplification, may benefit from epigenetic therapies targeting MYC transcriptional activity or from dietary interventions targeting metabolic addictions regulated by MYC.»
Knowing the dietary pattern of a patient or his level of physical activity, clinicians could eventually suggest some specific intervention to decrease the likelihood of progression to a lethal disease. But in order to do that, more research is needed.
«The impact of diet on cancer development has been first established more than 100 years ago. However, lifestyle-related data is only sparsely collected among patients, thereby limiting our capacity to define the molecular link between lifestyle factors and cancer initiation, progression and lethality,» says Dr. Labbé. «We will start soon here at the RI-MUHC to gather dietary and physical activity and assess body fatness information from patients undergoing screening tests for different cancers. And with that data, combined with research in the laboratory, we hope to be able to build personalized interventions for patients who are more at risk of having their cancer progress rapidly, and to ultimately improve outcomes.» Ученые узнали, какие продукты вызывают рак простаты. Постоянная ссылка на материал http://bt8.ru/prostatecanc/
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timetraveler-911 · 5 years ago
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climbing
Val di Murins at #Campill in #AltaBadia #SouthTyrol with 8 #historic #mills along the creek #Seres. #WednesdayMorning #OptOutside #EnjoyNature #AltoAdige #wasunsbewegt #nature #travel #Dolomiti #Lungiarù #2WonTour #ValdiMurins
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Climb the mountain not to plant your flag, but to embrace the challenge, enjoy the air and behold the view. Climb it so you can see the world, not so the world can see you. ~ David McCullough Jr. ~
Val di Morins at Campill / Lungiarù in the South Tyrol Region Alta Badia …
you might also like some of my collections about
South Tyrol
European Landscapes
Mother Nature
some more information in my German…
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hallmarkfanatic · 2 years ago
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August Hallmark Projects
Now let’s see what Hallmark brought up this month! Like always, all the information/speculation I put in this is based off of factors such as social media posts from different Hallmark actors/actresses, general social media info and/or a production website I look at often. Things such air dates, airing networks, co-stars, movie titles, etc, are always subject to change.
Aimee Teegarden and Evan Roderick - New York Autumn Love Story (Update) - We now have the leads and according to my twitter source, it’s one of 2 Fall premieres in October for the network.
Antonio Cupo - Christmas at the Golden Dragon - Director is David Strasser; Not sure is Cupo is staring or producing as of yet. But he is attached to the project.
Patti Murin and Brendan Penny - Christmas Carol Competition - Director is Paula Elle
Lacey Chabert and Wes Brown - Untitled Christmas Project - While it’s not confirmed, they apparently happen to be in the same filming location for an upcoming Christmas movie. So very high chance of this duo happening!
Katherine Barrell - Flight Before Christmas
Alison Sweeny - Christmas Village
Jonathan Bennett - A Manny for Christmas - Director: Ali Liebert
Lights, Camera, Christmas - Director is David Weaver - Very likely for Hallmark given David’s work throughout the network.
Christmas in the Big Easy - Director: Troy Scott
Christmas Italiano - Director: Catherine Cyran
When I Think of Christmas - Director: Peter Benson
Fit for Christmas - Director: Jessica Harmon
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thealmightyemprex · 2 years ago
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So for those who dont know Criterion has doublefeatures on their streaming service,and I decided to watch one called Cheap Tricks ,which was two B movies made by producer Jack Harris .The first film was the Blob ,which is a classic that I have seen multiple times ....The second film,the one I hsall talk about is a strange little flick called Equinox
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the plot of this 1970 film follows David (Edward Connell),Jim (Frank Bonner ) ,Susan (Barbara Hewitt),and Vicki (Robin Christopher) as they go for a picnic/meet up with Dr. Arthur Watermann (Fritz Lieber ) ,only to stumble upon an ancient book which they must keep out of the hands of Asmodeus (Jack Woods ) and his various demonic monsters
Now I will always have a soft spot for "Hey lets make our own movie " movies ,truly independent films appeal to me (I love the Blob for similar reasons ).The film actually reminds a LOT of Evil Dead which would be made a decade later ,not only due to the similar plot of a group of friends coming across a ancient book and being terroized by demonic forces,but in the group of amatures making a film feel.I also want to point out some of the people in this wnent on to bigger things like how Frank Bonner went onto appear in the sitcom WKRP in Cincinnati , David Allen went onto a lot of TV and Movie stop motion work (Dolls,Puppet Master ,The Howling ,Q the Winged Serpent ,etc ),and the film was the brain child of Denis Murin who went on to help found ILM ,and work on the likes of Star Wars and Jurassic Park . I think the effects scenes are great particularly all the stop motion,and the force perspective battle with the green giant .I like the main characters ,and though the acting can be stiff,thought most of them were pretty good
Now I wont lie ....It has goofy moments ,and most of them are courtesy of Jack Woods .See Denis Murin made the movie but when Jack Harris got ahold of it he wanted to add a few more scenes ,which were directed by Jack Woods ,who also play an added villain Asmodeous .....PRoblem is Woods isnt a great actor ,cause whenever he tries to be scary I am laughing,he's just really non threatening looking .In fact the film is more silly then scary .Also dont like the framing device
So yes it is not a perfect movie and I dont love it ....But I was never bored , its a fun watch,and I have nothing but respect for the people who made it.I feel like Ash describing the Xenomorph in Alien,"I admire its purity ".Making art is hard,and I admire this film for just existing
@the-blue-fairie @metropolitan-mutant-of-ark @ariel-seagull-wings @amalthea9 @princesssarisa @marquisedemasque@angelixgutz @filmcityworld1
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mplaylistdiaries · 3 years ago
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March 2018 Playlist
Summary: This is when I started making some changes to my life by limiting or cutting a lot of toxic people from my life. I warned one of my friends who still wished to interact with them about their toxic behaviors and they seemed to take it into consideration at the time, but things started ending up going south later eventually. Which, deeply saddened me because I sincerely treasured and care for that friendship, but I couldn’t keep holding on to it if they weren’t willing to do the same. However, I think it was necessary for me to experience it as well because this experience strengthened the relationships I had with my friends and made us definitely realize that we needed to be more open about our struggles physically, mentally, and socially on things. Therefore, I think this is one of my favorite playlists because it highlights the struggles of me letting those toxic relationship go, working on fostering my current relationships, and accepting the fact that I couldn’t keep pushing my friends away when I needed help because they care and love me for who I am. 
PLAYLIST LINK
Prelude by Fire Emblem Awakening
Santa Fe by Jermey Jordan
A Night To Remember by High School Musical Ensemble Cast
Crusin’ For A Brusin’ by Ross Lynch, Jason Evigan, and Grace Phipps
Carrying The Banner by Jermey Jordan & Newsies Ensemble Cast
Money, Money, Money by Meryl Streep, Julie Waters, and Christine Baranski
The Room Where It Happens by Leslie Odom Jr., Lin Manuel Miranda, David Diggs, Okieriete Onaodowan, and Hamilton Ensemble
I Want It All by Ashley Tisdale, Lucas Grabeel, and High School Musical Ensemble Cast
Sincerely, Me by Mike Faist, Ben Platt, and Will Roland
Two Birds by Regina Spector
Mystic Messenger (Cover) by Aruvn
Pretty Face by Public
Resonance by T.M. Revolution
What Do You Know About Love? by Patti Murin & Jellani Alladin
Winter’s Ball by Leslie Odom Jr., Lin Manuel Miranda, and Hamilton Ensemble Cast
Take A Hint by Victoria Justice, Elizabeth Gillies, and Victorious Ensemble Cast
Breathin’ by The Nor’easters
You Will Be Found by Ben Platt, Kristolyn Lloyd, Will Roland, Laura Dreyfuss, Dear Evan Hansen Ensemble Cast
Give Me A Break Stop Now by REOL
Divine Hammer by Audiomachine
Come Away To The Water ft. Rozzi Crane by Maroon 5
Kabaneri of the Iron Fortress by Ninelie
Come Little Children by The Hound + The Fox
Kingdom Come by The Civil Wars
The Flash Theme (Epic Version) by Samuel Kim Music 
Stay Alive by Hamilton Ensemble Cast
She’s Not There (Cover) by Glee Ensemble Cast
Eye of the Tiger by Survivor 
Courage (Cover) by AmaLee [Amanda Lee]
We Are by ONE OK ROCK
PLEDGE by ASCA
The World Will Know by Jeremy Jordan & Newsies Ensemble Cast
Strike Back (Cover) ft. Natewantstobattle [Nathan Smith] by AmaLee [Amanda Lee]
Bring It On by REOL
No Man’s Land by Rupert Greyson-Williams
PaperMoon by Tommy heavenly6
Lighthouse ft. Danielle Bennett by Alex Blue
Fools by The Nor’easters
Brave Shine by Aimer
Sia ft. Labrinth by To Be Human
Seize the Day by Ben Fankhauser, Jeremy Jordan, Newsies Ensemble Cast
Two Little Lines by Kasie Gasparini & Drew Gasparini
Monster by Caissie Levy, John Riddle, and Frozen Ensemble Cast
Redshift by Audiomachine
Why Should I Worry by Dan Hartman, Charlie Midnight, and Billy Joel
You’ll Be Back by Jonathan Groff & Hamilton Ensemble Cast
Master Oogway Suite by Jorah the Andal
Eye of the Needle by Sia
Shadowland by Heather Headley, Tsidii Le Loka, Lion King Ensemble Cast
I Will Survive by Gloria Gaynor
KOE by ASCA
What Comes Next by Jonathan Groff
No Turning Back Now by Jeremy Jordan
Paper Crown by Alec Benjamin
Eyes Open by Taylor Swift
I’m Just Your Problem by Olivia Olson & Adventure Time Ensemble Cast
It’s All Coming Back To Me Now by Glee Ensemble Cast
Overfly (Cover) by AmaLee [Amanda Lee]
Cecily Smith by Will Connolly and Michael Mitnick
Lay All Your Love On Me by Dominic Cooper & Amanda Seyfried
You’ll Be In My Heart by Phil Collins
Forever Here by Yoko Ishida
Mia & Sebastion’s Theme by Justin Hurwitz
Why Not? by Jonsi
Shirushi by LiSA
Evermore by Dan Stevens
We Don’t Talk Anymore ft. Selena Gomez by Charlie Puth
Catch The Moment by LiSA
Conquest by Fire Emblem Awakening
Like Other Girls by Paul Gordon
Super Mario Super Medley ft. Spencer Williams by David Fowler
Jump up, Super Star by Pauline
A Change In Me by Alan Menken, Doug Hammer, Steve Chaggaris, and Jean Danton
Sticks & Stones by Jonsi
Startear (Cover) by  AmaLee [Amanda Lee]
All Star by Smash Mouth
Stand Out by Tevin Campbell
History Maker (Cover) by Aruvn
The Lotto by Ingrid Michaelson & AJR
Son of Man by Phil Collins
Hope by Namie Amuro
A Lovely Night by Ryan Gosling & Emma Stone
Crossing Field by LiSA
Can You Feel The Love Tonight by Heather Headley, Jason Raize, Max Casella, Tom Alan Robbins, Lion King Ensemble Cast
What A Wonderful Love by The Hound + The Fox
City of Stars ft. Emma Stone by Victor Hugo
In A Crowd of Thousands by Derek Klena & Christy Altomare
The Color of Your Eyes by Megan McGinnis & Paul Alexander Nolan
Always Coming Back by ONE OK ROCK
We’re the Stars by Aimi Terakawa
I’m A Believer by Smash Mouth
I Never Planned On You/ Don’t Come A-Knocking 
Ours by Taylor Swift 
Might U by Makayla Phillips
At The Beginning by Richard Marx & Donna Lewis
I2I by Tevin Campbell & Rosie Gaines
Finale by Jeremy Jordan & Newsies Ensemble Cast
La La Land (Epilogue) by Justin Hurwitz 
Super Powers by V6
Kung Fu Fighting by Shanghai Musical Choirs
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larryland · 4 years ago
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REVIEW: "Coming Back Like a Song!" at the Berkshire Theatre Group
REVIEW: “Coming Back Like a Song!” at the Berkshire Theatre Group
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tenshichan1013 · 5 years ago
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disney broadway quality time
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rogerdellibovi · 6 years ago
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No one I know irl cares about the Tonys so please talk to me about who you think will win/who you wish will win ?
Ah thanks for asking me because I wanted to actually take my bets! Only gonna do musicals cause I don’t know much about the plays
Best musical:
Prediction: The Band’s Visit
If I were the atw: Mean Girls
Best revival:
Prediction: My Fair Lady
If I were the atw: Once on This Island
Leading Actress:
Prediction: Katrina Lenk
If I were the atw: Patti Murin Taylor LoudermanLeading Actor:
Prediction: Joshua Henry
If I were the atw: idk Tony Shalhoub?
Featured Actress:
Prediction: Ashley Park
If I were the atw: Ashley Park
Featured Actor:
Prediction: Norbert Leo ButzIf I were the atw: Grey Henson
Best director:
Prediction: David CromerIf I were the atw: MICHAEL ARDEN
Best Score:Prediction: The Band’s VisitIf I were the atw: y'all can hate me but FROZEN
Best book:Prediction: Mean GirlsIf I were the atw: Mean Girls
Best Choreography:Prediction: CarouselIf I were the atw: Once on This Island
Best Orchestrations:Prediction: The Band’s VisitIf I were the atw: The Band’s Visit
Costumes:Prediction: My Fair LadyIf I were the atw: FROZEN Once on This Island
Lighting: Prediction: SpongebobIf I were the atw: idk anything about lighting
Scenic design:Prediction: My Fair LadyIf I were the atw: FROZEN Once on This Island
Sound:Prediction: SpongebobIf I were the atw: idk anything about sound design so
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msclsfan-blog · 6 years ago
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RECENT BOOTS
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My full list can be found at: msclsfan.weebly.com Please feel free to message me through my site, or just here on tumblr, if you are interested in trading (I also do gifting!) Videos: ​The Band's Visit | Broadway Previews | October 16, 2017 | .VOB Tony Shalhoub (Tewfiq Zakaria), Katrina Lenk (Dina), George Abud (Camal), Etai Benson (Papi), John Cariani (Itzik), Adam Kantor (Telephone Guy), Andrew Polk (Avrum), Ari'el Stachel (Haled), Bill Army (Zelger), Rachel Prather (Julia), Jonathan Raviv (Sammy), Sharone Sayegh (Anna), Kristen Sieh (Iris), Alok Tewari (Simon) Book of Mormon | West End | May 29, 2013 | .VOB Gavin Creel (Elder Price), Daniel Buckley (st/by Elder Cunningham), Alexia Khadime (Nabulungi), Giles Terera (Mafala Hatimbi), Stephen Ashfield (Moroni/Elder McKinley), Tosh Wanogho-Maud (u/s General), Haydn Oakley (Price's Dad/Joseph Smith/Mission President). Book of Mormon | First National Tour - Costa Mesa, CA | May 17, 2014 | .mp4 David Larsen (Elder Price), Cody Jamison Strand, Tallia Brinson (u/s Nabulungi), Jeff Heimbrock (u/s Cunningham's Dad), Pierce Cassedy, James Vincent Meredith, David Aron Damane, Christopher Shyer Book of Mormon | Second National Tour - Cincinnati, Ohio April 2, 2016 | .VOB Ryan Bondy (Elder Price), Cody Jamison Strand (Elder Cunningham), Candace Quarrels (Nabulungi), Daxton Bloomquist (Elder McKinley/Moroni), Sterling Jarvis(Mafala Hatimbi), David Aron Damane (General), Edward Watts (Price’s Dad/Joseph Smith), CJ Pawlikowski (Cunningham’s Dad) Frozen | OBC | Pre-Broadway - Denver, CO | October 1, 2017 | .VOB Caissie Levy (Elsa), Patti Murin (Anna), Julani Alladin (Kristoff), Greg Hildreth (Olaf), John Riddle (Hans), Timothy Hughes (Pabbie), Robert Creighton (Weselton), Andrew Pirozzi (Sven), Audrey Bennett (Young Anna), Ayla Schwartz (Young Elsa) Fun Home | OBC | Broadway | March 29, 2015 | .VOB Beth Malone (Allison), Emily Skeggs Small (Medium Allison), Sydney Lucas (Allison), Michael Cerveris (Bruce), Judy Kuhn (Helen) Oscar Williams (Christian), Zell Morrow (John), Joel Perez (Roy) ,Roberta Colindrez (Joan) Legally Blonde | Broadway | September 2, 2007 | .VOB Laura Bell Bundy (Elle), Andy Karl (u/s Emmett), Orfeh (Paulette), Richard H. Blake (Warner), Kate Shindle (Vivienne), Nikki Snelson (Brooke/Shandi), Michael Rupert (Professor Callahan), Annaleigh Ashford (Margot), Natalie Joy Johnson (Enid/Veronica), Matthew Risch (Dewey/Kyle u/s) Notes: Les Misérables | West End | September 19, 2013 | .mp4 Daniel Koek (Valjean), James Gant (u/s Javert), Na-Young Jeong (Fantine), Carrie Hope Fletcher (Eponine), Rob Houchen (Marius), Samantha Dorsey (Cosette), Anton Zetterholm (Enjolras) Mamma Mia! | Broadway | November 21, 2012 | .VOB  Christy Altomare (Sophie), Natalie Bradshaw/Monica Kapoor (u/s Ali), Thomasina Gross (Lisa), Felicia Findley (Tanya), Laureen Cohn (Rosie), Judy McLane (Donna), Zak Resnick (Sky), Graham Rowat (Harry), Daniel Cooney (Bill), Aaron Lazar (Sam)
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