#Brain Tumor

[reasonsforhope]

"In a first-ever human clinical trial, an mRNA cancer vaccine developed at the University of Florida successfully reprogrammed patients’ immune systems to fiercely attack glioblastoma, the most aggressive and lethal brain tumor.

The results in four adult patients mirrored those in 10 pet dog patients suffering from brain tumors whose owners approved of their participation.

The discovery represents a potential new way to recruit the immune system to fight treatment-resistant cancers using an iteration of mRNA technology and lipid nanoparticles, similar to COVID-19 vaccines, but with two key differences: use of a patient’s own tumor cells to create a personalized vaccine, and a newly engineered complex delivery mechanism within the vaccine.

“Instead of us injecting single particles, we’re injecting clusters of particles that are wrapping around each other like onions,” said senior author Elias Sayour, M.D., Ph.D., a UF Health pediatric oncologist who pioneered the new vaccine, which like other immunotherapies attempts to “educate” the immune system that a tumor is foreign.

“These clusters alert the immune system in a much more profound way than single particles would.”

Among the most impressive findings was how quickly the new method spurred a vigorous immune-system response to reject the tumor, said Sayour, principal investigator at the University’s RNA Engineering Laboratory and McKnight Brain Institute investigator who led the multi-institution research team.

“In less than 48 hours, we could see these tumors shifting from what we refer to as ‘cold’—very few immune cells, very silenced immune response—to ‘hot,’ very active immune response,” he said.

“That was very surprising given how quick this happened, and what that told us is we were able to activate the early part of the immune system very rapidly against these cancers, and that’s critical to unlock the later effects of the immune response,” he explained in a video (below).

Glioblastoma is among the most devastating diagnoses, with median survival around 15 months. Current standard of care involves surgery, radiation and some combination of chemotherapy.

The new report, published May 1 in the journal Cell, is the culmination of seven years of promising studies, starting in preclinical mouse models.

In the cohort of four patients, genetic material called RNA was extracted from each patient’s own surgically removed tumor, and then messenger RNA (mRNA)—the blueprint of what is inside every cell, including tumor cells—was amplified and wrapped in the newly designed high-tech packaging of biocompatible lipid nanoparticles, to make tumor cells “look” like a dangerous virus when reinjected into the bloodstream to prompt an immune-system response.

The vaccine was personalized to each patient with a goal of getting the most out of their unique immune system...

While too early in the trial to assess the clinical effects of the vaccine, the patients either lived disease-free longer than expected or survived longer than expected. The 10 pet dogs lived a median of 4.5 months, compared with a median survival of 30-60 days typical for dogs with the condition.

The next step, with support from the Food and Drug Administration and the CureSearch for Children’s Cancer foundation, will be an expanded Phase I clinical trial to include up to 24 adult and pediatric patients to validate the findings. Once an optimal and safe dose is confirmed, an estimated 25 children would participate in Phase 2."

-via Good News Network, May 11, 2024

-video via University of Florida Health, May 1, 2024

[eretzyisrael]

[laura1633]

Imagine that Max started vomiting in the morning for two days and have nausea and when he searched in google it shows that it maybe a brain tumor which made him go completely dramatic when Charles came home he found Max on the bed telling him that he feels so tired and in pain and that if he dies take care of the cats and Leo , Charles is about to lose his mind because he can’t accept that idea, he takes Max to the doctor and while she’s doing the sonar test she was trying hard to contain her laugh because Max was saying to Charles “ If I die I want you to love someone else and not be sad for a long time .. be sad for like two years.. three years actually and then date someone but don’t love them like you loved me love them half as much as you love me and don’t call them princess okay? “ and Charles is not listening he’s just too worried about Max but when Max say against “ Okayy??” So Charles just say okay and Max gasps “ Okay?! You will love someone else when I die?! You were waiting for me to die right?!” With tears and Charles says “What??” And Max starts crying “he’s pierre isn’t he? I knew you loved him more than me “ and Charles is so confused “ Max what?! No ew no!” And Max crying says” yes you do-“ but the doctor interpreted him saying “ Mr Leclerc you’re not going to die you’re pregnant “ and Max is like “ oh “ and Charles is speechless he was just about to go crazy because he though his husband will die and now he’s trying to understand Max is pregnant 😂😂😂

Oh god, Max telling Charles to wait two years first and then deciding no, three years is more acceptable Hahaha

Looking up symptoms of illnesses on google is never a good idea because it nearly always seems to give you the most dramatic and awful result first!! Poor Max 😂

This probably means they are both going to be super panicky throughout the pregnancy and Charles always fussing over Max and making sure he is okay and wanting to rush to the hospital whenever Max has any aches or pains.

[redditreceipts]

So this is the answer to an ask that @wild-wombytch has sent me, and I chose to answer it in this format because the original ask contains a link to a post that I'd rather not share, to maintain respectful of OP.

Thank you, I'm fine! and cool that you like the cat pictures ❤️ I'll make a separate post for you just containing cat pictures

and thank you so much for saying that! ❤️❤️

yeah, so @wild-wombytch refers to a post that deals with a person who got a tumor from HRT. They have made a post in a mainstream trans subreddit and the people on there got mad at them, because they didn't want to recognise the downsides of HRT:

So this is just a whole other level. People hating on OP because they got a brain tumor is so despicable. These people can rot in hell

(Also, if you want to use my post to make fun of OP for having a brain tumor, enjoy getting blocked 🥰 I try to make this a welcoming place for people who are transitioning, detransitioning or having problems with their medical transition. If you can't handle that, please fuck off)

The specific kind of tumor this person is talking about, a pituitary brain tumor, is (as stated) probably linked to HRT in trans women. This reminds me of the myriad of posts by trans women talking about galactorrhea. Galactorrhea refers to the spontaneous lactation without having given birth or breastfeeding a baby, which can occur in women and men. And what is the most common cause for Galactorrhea?

the most common cause of galactorrhea is a benign tumor in your brain. Even though benign tumors are not as dangerous as cancerous tumors, they can still cause severe dysfunction over time, because they can still grow slowly and compress vital areas of the brain. It's definetly not a topic to be joked about.

I was able to find a ton of "I am spontaneously lactating as a trans woman, is this normal"-posts in the span of seconds. Remember: Galactorrhea, a condition that is most commonly caused by a brain tumor. And what are the responses?

keep in mind: this person probably had not only been lactating, but even had blood in their nipple discarge. Up to a fifth of women who have that sign of discharge have a malignant cause for it - I can't imagine that the prospect for biological males on HRT is much better.

so yeah, instead of telling them to go see their doctor or anything, they link them to r/AdultBreastfeeding - it's a fetish subreddit for people who have a lactation fetish and want to induce lactation.

I mean, a large amount of the stuff I post here is kinda funny and absurd, but if you get a bit deeper in these online echochambers, it gets really dark real quick. Where did we go from "everyone should live their lives as they wish" to "downplaying brain cancer to own the terfs"? And this doesn't mean that every trans woman should immediately stop their HRT just to prevent that from happening. That's not what I'm saying here. I'm just saying that these people genuinely don't seem to care about anything other than their ideology, and even medical professionals are seen as "lying" and "bigoted", and people with brain tumors are accused of "attacking the trans community". How is this not a cult??

Also, I wish the person who made the original post all the best :) I hope they find people who support them and help them heal

[angryschnauzer]

Hubby had his final clinic appointment today. I was so fucking anxious, i was sure they would have found regrowth of the brain tumour or that his bloods wouldn't be good enough for the final round of chemo, but i was proven wrong thankfully.

No regrowth. Blood platelets high enough for his final round of chemo. He's been given the all clear to fly so we can look at going on holiday in October to Malta.

Going forwards he will have MRI scans every two to three months for the rest of his life, and there is a 95% chance the cancer will come back at some point in the next five years. But for now, we are in the clear.

I'm not celebrating just yet, but my anxiety has dropped considerably.

[polpocomune]

Brain Tumor - I need help

LONG OVER DUE UPDATE 2024 (29/July/2024)!: Still doing some tests, this is going to go on for a long time. I'm not in a urgency right now and will probably do another final update in September (officially a year after surgery). I'm very grateful for all the people that have helped me, thank you!

UPDATE (3/November/2023):

I haven't fully paid all my debts so I still have active my gofundme page in case anybody wants to help, I would really appreciate it.

Currently still doing more tests in order to see if there is any tumor residue, in case I need another treatment. Thank you for your support.

UPDATE (10/September/2023):

I got surgery!! Currently in recovery. THANK YOU SO MUCH!! T__T

----------------------------

Hello! I know I don’t have many followers and I’m just another random tumblr user but if you guys could help me share this I would be forever grateful. English is not my first laungage so excuse me if I make any mistake.

On Monday, May 1, around 2 p.m. in the afternoon, I had an epileptic fit. They took me to the ER because the seizures wouldn't stop, then they transferred me to a second hospital where they did a CT scan, but nothing abnormal came out, so they transferred me back to the first hospital. I kept convulsing and I got to the point of being intubated, since I was having breathing difficulties. Until the next day, around 4 a.m., I was able to wake up and was discharged in the afternoon since I looked more stable.

After going to the neurologist and doing several more in-depth studies, they concluded that the epileptic seizures were due to the fact that I have a brain tumor in the upper frontal part. I still have time to extract it, however, the surgery is very expensive for me, approximately $11,760 dollars. That's why I need any help I can get.

I appreciate any contribution even if it is only sharing my cause or having read this far. Thank you so much. ❤️

https://gofund.me/0e392ec8

[lilfoxy1013]

Alrighty.. just putting this here for safekeeping and so maybe it’ll be easier to explain. On Feb 17, 2024 my boyfriend at the time woke up around 9:30 am to me having a seizure. He took me to a research hospital in the area and we got to the ED around 11 am. They did a CT and an MRI and have found what they called a 4 cm tumor in my right frontal lobe. I had another MRI in the middle of March and got more measurements on the size of the tumor. Based on the measurements, I did the math and found it was 119 cubic cm (about the size of a billiards ball). I had a right frontal craniotomy on April 1, 2024. They were able to remove the entire tumor and my MRI the evening after surgery showed no residual tumor. I’ve met with an oncologist and we waited for pathology results. Pathology came back as a Grade 3 Astrocytoma with the IDH1 mutation. I have started 500 mg of Tibsovo daily to keep it from growing back, or at least slow it down. There isn’t a cure for brain tumors, so we just wait for it to come back and do surgery again. If you’ve read this far into my real life shit, I appreciate any well wishes, thoughts, and prayers if you’re religious. I try to keep my spirits up and handle things rationally but some days that is a little more difficult. I’m stuck on antiseizure medication for at least a year from my latest seizure (luckily it’s still just the seizure in Feb 2024) and cannot drive per my state’s laws for a year from the last seizure as well.

Luckily my job has been flexible with me since February but trying to get back to full time hours is a struggle, especially if I want to take care of myself as well (bathing, eating, cleaning, etc). Also, lots of back and forth with insurance companies and the hospital and lots of scans and follow up appointments.

6 month MRI was clean. “No progression” and “stable burden of disease”. Joint pain has been mostly managed with new meds.

I moved in with my “friends” who turned into girlfriend, fiancée, and wife very quickly (we had a hand fasting ceremony Oct 6, 2024) and her husband became my boyfriend as well. Being in a functional throuple is new to them, so there have been some hiccups but everything is looking up. 💜

[cbirt]

Tumors that affect the central nervous system are among the most fatal kinds of cancer, especially in pediatric cases. Surgical removal of the tumor is usually the prescribed course of action, made harder by the fact that the surgeons performing the procedure will not be able to determine the kind of tumor they’re dealing with beforehand, limiting their ability to come up with a plan in advance. A new tool utilizing neural networks seeks to improve the landscape of cancer diagnostics by providing a rapid and accurate mechanism to classify CNS tumors in an intraoperative setting.

Primary treatments for tumors of the nervous system usually involve the excision of the tumor through surgery, this is a difficult procedure to perform, requiring surgeons to make decisions regarding how much of it can be excised without posing a threat to the neural system and increasing the chances of comorbidity.

The determination of the kind of tumor is crucial to be able to identify the necessity and amount of resection that can be feasibly carried out. Certain tumors are presently viewed as being incurable, hence, the surgeon’s aim while operating on a patient must be to acquire tissue samples for proper diagnosis while preserving the patient’s quality of life as much as possible. However, it may be beneficial to attempt a complete resection as possible for other kinds of tumors, as it improves survival.

Continue Reading

[peoplefully]

Hey I know this is the no money website and bigger things need attention but if you could offer help to my family in our time of need.

https://gofund.me/83b70532

My family members dad was diagnosed with a rare brain tumour that they were unable to remove. There are more expensive treatments to make his chemotherapy more bearable (expanded better in her own words) I'm really worried about them and would like to request kindness

[redmegarex]

i have a brain tumor :D

[martian-martian-martian]

just my two cents but— can all of media for fucking ever please stop with the whole

“this character has a brain tumor so they’re gonna go CRAZYYYYYY!!! and start HALLUCINATING!!!! and its acid trippy wacky bootleg schizophrenia!!! WooooOoooo! Their BRAIN is BROKEN they’re going Nuts!!!! They’ve completely changed personalities!!!”

my mom had a brain tumor. one of the most fast acting and lethal. you know what happened? she got really really tired, started having seizures, progressively lost motor function, and died in her sleep.

her personality didn’t change, she didn’t have visions, or become a murderer. she was fully conscious and the same woman she always was. in fact, she fought very hard to REMIND people of that because the MISINFORMATION about brain tumors was so pervasive, people used to treat her like she was losing her mind and it broke her heart because she WASN’T.

brain tumors overwhelmingly affect motor function, and the changes in interaction are most often things like increased confusion, dizziness, and fatigue

brain tumors are not just a dramatic narrative swap out for dementia, or alzheimers, or schizophrenia. all three of which should ALSO not be constantly mischaracterized as horror-fodder, by the way.

i’m so sick of people using brain tumors as a secret hack for making a character go crazy or hallucinate or become evil or some other horseshit. it’s factually untrue and just lazy writing.

there’s lots of other ways to have a character hallucinate, and lots of reasons to go become a mass murderer lmao.

hell, CHILDREN get glioblastomas all the time. and guess what: they remain the same pretty fuckin scared but otherwise normal kids.

frankly, i respect the saw franchise because even though Jigsaw is indeed a mass murderer, his brain tumor didnt evil-lize him, it was facing the realities of a heartless medical industrial complex.

[spoonful116]

Insurance companies, periodically: hey, is that permanent disability still there?

[the-withering-system]

Odd question maybe, probably as I've not found an answer to my exact questions but anyway.

Does anyone know how often benign brain growth needs to be scanned? Specifically Lipomas. I know it's grown in the past couple years by a few mm but I'm not sure when I should get it rescanned. Last MRI & CT was in 2021 so I feel like it's reasonable to request one.

My doc isn't much help, she was of the opinion I didn't need to know it existed and should be living blissfully unaware. Honestly the only reason I'm questioning if it needs to be rescanned is because of her reaction and the fact it's a lipoma in an inoperable area.

But it's growing and that's scary

[fedorahead]

So my friend Nova (Jenny) found out she has a tumour in her brain. She's going in for surgery at 6:30 (I assume EST) to have a shunt put in while awaiting biopsy results.

I wrote a thing for Facebook when I shared the gofundme her friend set up, but I realized I could try sharing it here too and see if anyone on here was interested in helping.

anyway here's what i wrote on facebook

Jenny's been my friend for like seven years at this point, and that makes me qualified to assert that she's the sweetest person on this fucking planet, and probably the least worthy of something like this. She's under the care of some of the top doctors in the country, and the country is the US so you know how healthcare can be.

Donate if you can, and if you know any spells/illuminati that owe you a favour/have some sort of an in with your local deity, please give that a shot and see if we can make this tumour benign.

I got that fortune the other day that said my luck would change, and since then my luck's been 10x worse, so I hope it's because the good luck got reallocated to her.

If you can donate or send whatever energy/agents of chaos/well wishes her way, a whole lot of people whose lives she consistently makes better would appreciate it.

Here's a link to her public post linking this gofundme (to show it's got her sanction)

Here's the original public post about the tumour (she had other posts about her migraines since the 2nd, but obviously none of us saw this coming)

[hannahcrazyhawk]

My new Wishlist:

💜

[lilfoxy1013]

@lilfoxy1013 Hi, just wanted to to see how you been doing lately?

I appreciate you asking! Things are okay for right now. New meds to help with joint pain, physical therapy for the headaches, and my 3 month MRI was almost completely clean! There’s one little spot that my neuro-oncologist wants to keep an eye on, but she isn’t concerned about it yet.