#Brain Tumor

[zombbean]

Please check out my go fund me.

[reasonsforhope]

"In a first-ever human clinical trial, an mRNA cancer vaccine developed at the University of Florida successfully reprogrammed patients’ immune systems to fiercely attack glioblastoma, the most aggressive and lethal brain tumor.

The results in four adult patients mirrored those in 10 pet dog patients suffering from brain tumors whose owners approved of their participation.

The discovery represents a potential new way to recruit the immune system to fight treatment-resistant cancers using an iteration of mRNA technology and lipid nanoparticles, similar to COVID-19 vaccines, but with two key differences: use of a patient’s own tumor cells to create a personalized vaccine, and a newly engineered complex delivery mechanism within the vaccine.

“Instead of us injecting single particles, we’re injecting clusters of particles that are wrapping around each other like onions,” said senior author Elias Sayour, M.D., Ph.D., a UF Health pediatric oncologist who pioneered the new vaccine, which like other immunotherapies attempts to “educate” the immune system that a tumor is foreign.

“These clusters alert the immune system in a much more profound way than single particles would.”

Among the most impressive findings was how quickly the new method spurred a vigorous immune-system response to reject the tumor, said Sayour, principal investigator at the University’s RNA Engineering Laboratory and McKnight Brain Institute investigator who led the multi-institution research team.

“In less than 48 hours, we could see these tumors shifting from what we refer to as ‘cold’—very few immune cells, very silenced immune response—to ‘hot,’ very active immune response,” he said.

“That was very surprising given how quick this happened, and what that told us is we were able to activate the early part of the immune system very rapidly against these cancers, and that’s critical to unlock the later effects of the immune response,” he explained in a video (below).

Glioblastoma is among the most devastating diagnoses, with median survival around 15 months. Current standard of care involves surgery, radiation and some combination of chemotherapy.

The new report, published May 1 in the journal Cell, is the culmination of seven years of promising studies, starting in preclinical mouse models.

In the cohort of four patients, genetic material called RNA was extracted from each patient’s own surgically removed tumor, and then messenger RNA (mRNA)—the blueprint of what is inside every cell, including tumor cells—was amplified and wrapped in the newly designed high-tech packaging of biocompatible lipid nanoparticles, to make tumor cells “look” like a dangerous virus when reinjected into the bloodstream to prompt an immune-system response.

The vaccine was personalized to each patient with a goal of getting the most out of their unique immune system...

While too early in the trial to assess the clinical effects of the vaccine, the patients either lived disease-free longer than expected or survived longer than expected. The 10 pet dogs lived a median of 4.5 months, compared with a median survival of 30-60 days typical for dogs with the condition.

The next step, with support from the Food and Drug Administration and the CureSearch for Children’s Cancer foundation, will be an expanded Phase I clinical trial to include up to 24 adult and pediatric patients to validate the findings. Once an optimal and safe dose is confirmed, an estimated 25 children would participate in Phase 2."

-via Good News Network, May 11, 2024

-video via University of Florida Health, May 1, 2024

[newyorkthegoldenage]

The early days of radiation treatment for cancer. Radiation technicians Nancy Brown, right, and Isabelle Nauer illustrate the use of the Cobalt “bomb” machine at Montefiore Hospital in the Bronx as the new therapy unit makes its bow, February 7, 1953. Nauer wears a plaster cast of the type molded on a patient’s head in a brain tumor case. After conventional x-rays locate the tumor, the cast is marked so that the Cobalt unit can be directed at the same point during each treatment. The “bomb” came from Canada’s Chalk River Atomic Energy pile and produced more radiation than all the world’s medically used radium.

Photo: Associated Press via WHNT

[eretzyisrael]

[laura1633]

Imagine that Max started vomiting in the morning for two days and have nausea and when he searched in google it shows that it maybe a brain tumor which made him go completely dramatic when Charles came home he found Max on the bed telling him that he feels so tired and in pain and that if he dies take care of the cats and Leo , Charles is about to lose his mind because he can’t accept that idea, he takes Max to the doctor and while she’s doing the sonar test she was trying hard to contain her laugh because Max was saying to Charles “ If I die I want you to love someone else and not be sad for a long time .. be sad for like two years.. three years actually and then date someone but don’t love them like you loved me love them half as much as you love me and don’t call them princess okay? “ and Charles is not listening he’s just too worried about Max but when Max say against “ Okayy??” So Charles just say okay and Max gasps “ Okay?! You will love someone else when I die?! You were waiting for me to die right?!” With tears and Charles says “What??” And Max starts crying “he’s pierre isn’t he? I knew you loved him more than me “ and Charles is so confused “ Max what?! No ew no!” And Max crying says” yes you do-“ but the doctor interpreted him saying “ Mr Leclerc you’re not going to die you’re pregnant “ and Max is like “ oh “ and Charles is speechless he was just about to go crazy because he though his husband will die and now he’s trying to understand Max is pregnant 😂😂😂

Oh god, Max telling Charles to wait two years first and then deciding no, three years is more acceptable Hahaha

Looking up symptoms of illnesses on google is never a good idea because it nearly always seems to give you the most dramatic and awful result first!! Poor Max 😂

This probably means they are both going to be super panicky throughout the pregnancy and Charles always fussing over Max and making sure he is okay and wanting to rush to the hospital whenever Max has any aches or pains.

[skyferreirastan]

hey everyone, serious matters today (sky ferreira related)

Sky Ferreira's mother, Tonia, is going through treatment for brain tumor and can't afford to pay all of her medical bills. Tonia has always been hard-working and is a caring mother. She was an active supporter and contributor of the Free Sky Ferreira movement throughout the whole campaign. Her youngest daughter Athena started a fundraiser to help her with all the medical bills, she gave details about her condition and treatment in the description of the gofundme. Tonia also suffers from lupus and it's not the first time she has brain tumors (see screenshot below). Sky's grandma Carol and Sky herself can't pay all by themselves either, Sky's grandma apparently said her business was too slow right now...

Please donate on the link below if you'd like to help them. And don't forget to share. ❤️

[angryschnauzer]

Hubby had his final clinic appointment today. I was so fucking anxious, i was sure they would have found regrowth of the brain tumour or that his bloods wouldn't be good enough for the final round of chemo, but i was proven wrong thankfully.

No regrowth. Blood platelets high enough for his final round of chemo. He's been given the all clear to fly so we can look at going on holiday in October to Malta.

Going forwards he will have MRI scans every two to three months for the rest of his life, and there is a 95% chance the cancer will come back at some point in the next five years. But for now, we are in the clear.

I'm not celebrating just yet, but my anxiety has dropped considerably.

[lilfoxy1013]

Alrighty.. just putting this here for safekeeping and so maybe it’ll be easier to explain. On Feb 17, 2024 my boyfriend at the time woke up around 9:30 am to me having a seizure. He took me to a research hospital in the area and we got to the ED around 11 am. They did a CT and an MRI and have found what they called a 4 cm tumor in my right frontal lobe. I had another MRI in the middle of March and got more measurements on the size of the tumor. Based on the measurements, I did the math and found it was 119 cubic cm (about the size of a billiards ball). I had a right frontal craniotomy on April 1, 2024. They were able to remove the entire tumor and my MRI the evening after surgery showed no residual tumor. I’ve met with an oncologist and we waited for pathology results. Pathology came back as a Grade 3 Astrocytoma with the IDH1 mutation. I have started 500 mg of Tibsovo daily to keep it from growing back, or at least slow it down. There isn’t a cure for brain tumors, so we just wait for it to come back and do surgery again. If you’ve read this far into my real life shit, I appreciate any well wishes, thoughts, and prayers if you’re religious. I try to keep my spirits up and handle things rationally but some days that is a little more difficult. I’m stuck on antiseizure medication for at least a year from my latest seizure (luckily it’s still just the seizure in Feb 2024) and cannot drive per my state’s laws for a year from the last seizure as well.

Luckily my job has been flexible with me since February but trying to get back to full time hours is a struggle, especially if I want to take care of myself as well (bathing, eating, cleaning, etc). Also, lots of back and forth with insurance companies and the hospital and lots of scans and follow up appointments.

6 month MRI was clean. “No progression” and “stable burden of disease”. Joint pain has been mostly managed with new meds.

I moved in with my “friends” who turned into girlfriend, fiancée, and wife very quickly (we had a hand fasting ceremony Oct 6, 2024) and her husband became my boyfriend as well. Being in a functional throuple is new to them, so there have been some hiccups but everything is looking up. 💜

9 month post op MRI came back with no suspicious activity to suggest disease progression or recurrence, so that’s a win! I’m almost able to legally drive in Arkansas again (very stupid seizure law here). The wifey’s husband and I are not pursuing a relationship right now to keep our household as stable as possible, but I think it’s for the best long term ☺️

[polpocomune]

Brain Tumor - I need help

LONG OVER DUE UPDATE 2024 (29/July/2024)!: Still doing some tests, this is going to go on for a long time. I'm not in a urgency right now and will probably do another final update in September (officially a year after surgery). I'm very grateful for all the people that have helped me, thank you!

UPDATE (3/November/2023):

I haven't fully paid all my debts so I still have active my gofundme page in case anybody wants to help, I would really appreciate it.

Currently still doing more tests in order to see if there is any tumor residue, in case I need another treatment. Thank you for your support.

UPDATE (10/September/2023):

I got surgery!! Currently in recovery. THANK YOU SO MUCH!! T__T

----------------------------

Hello! I know I don’t have many followers and I’m just another random tumblr user but if you guys could help me share this I would be forever grateful. English is not my first laungage so excuse me if I make any mistake.

On Monday, May 1, around 2 p.m. in the afternoon, I had an epileptic fit. They took me to the ER because the seizures wouldn't stop, then they transferred me to a second hospital where they did a CT scan, but nothing abnormal came out, so they transferred me back to the first hospital. I kept convulsing and I got to the point of being intubated, since I was having breathing difficulties. Until the next day, around 4 a.m., I was able to wake up and was discharged in the afternoon since I looked more stable.

After going to the neurologist and doing several more in-depth studies, they concluded that the epileptic seizures were due to the fact that I have a brain tumor in the upper frontal part. I still have time to extract it, however, the surgery is very expensive for me, approximately $11,760 dollars. That's why I need any help I can get.

I appreciate any contribution even if it is only sharing my cause or having read this far. Thank you so much. ❤️

https://gofund.me/0e392ec8

[colombiantie]

I've been thinking for a long time who Agent Smith reminds me of and here it is. Yes, maybe they're not exactly twins in appearance, just the shape of their heads, their hairstyle, the color of their eyes, the similar distance between their lips and their noses and of course their costumes. A bit strange, right?

[cbirt]

Tumors that affect the central nervous system are among the most fatal kinds of cancer, especially in pediatric cases. Surgical removal of the tumor is usually the prescribed course of action, made harder by the fact that the surgeons performing the procedure will not be able to determine the kind of tumor they’re dealing with beforehand, limiting their ability to come up with a plan in advance. A new tool utilizing neural networks seeks to improve the landscape of cancer diagnostics by providing a rapid and accurate mechanism to classify CNS tumors in an intraoperative setting.

Primary treatments for tumors of the nervous system usually involve the excision of the tumor through surgery, this is a difficult procedure to perform, requiring surgeons to make decisions regarding how much of it can be excised without posing a threat to the neural system and increasing the chances of comorbidity.

The determination of the kind of tumor is crucial to be able to identify the necessity and amount of resection that can be feasibly carried out. Certain tumors are presently viewed as being incurable, hence, the surgeon’s aim while operating on a patient must be to acquire tissue samples for proper diagnosis while preserving the patient’s quality of life as much as possible. However, it may be beneficial to attempt a complete resection as possible for other kinds of tumors, as it improves survival.

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[ginstermoff]

So there's at least two brain tumors in my head. Please please please let me be the exception and let them just fade away on their own.

[tempest-melody]

Helping Out a Friend | Writing Group Update

Life throws us interesting curve balls. A little over two years ago Keltin and I joined the Denton Writing Club on a whim as a chance to explore creative writing with like-mined people. We have made some amazing friends being part of this community. That being said: I never thought that I would end up leading the group. In December of 2024 the partner (Thomas) of the Founder and President of the…

[allangstnocomfort]

‼️NEW CHAPTER‼️

After The Fall, Comes The Fight

Chapter 3

[peoplefully]

Hey I know this is the no money website and bigger things need attention but if you could offer help to my family in our time of need.

https://gofund.me/83b70532

My family members dad was diagnosed with a rare brain tumour that they were unable to remove. There are more expensive treatments to make his chemotherapy more bearable (expanded better in her own words) I'm really worried about them and would like to request kindness

[redmegarex]

i have a brain tumor :D