#Antifreeze

[jakobsdoodles]

Thank you @artisfox and mystery anon for your interest in my sparkling Antifreeze! Here he is meeting his uncles, who love him and he loves them <3

apologies if tumblr makes the quality look crunchy :/

[macgyvermedical]

Antidote Quiz 2: Ethylene Glycol (the poisonous kind of antifreeze)

Oh No!

Your action hero blorbo was poisoned with ethylene glycol!

You have access to the following antidotes, but, crucially, no time to google it (your internet is like, really slow), which are you going to use?

[misforgotten2]

Made from only the finest farm raised goose grease.

Life - November 17th 1947

[flyingkitesman]

[justkidneying]

Why You're Hungover on Monday Morning

So you know when you get drunk and feel like shit the next day? Have you ever wanted to be able to drink without getting a hangover? Well, I can't really help you there, but I can at least tell you why hair of the dog doesn't work.

Ethanol (CH3CH2OH): this is normal drinking alcohol. When you drink it, most of it gets dumped into your blood and into the liver. What does the liver do with it? It breaks it down into acetaldehyde (which is very toxic) and then breaks that down to acetate. The enzymes involved are Alcohol Dehydrogenase (in the cytosol) and Acetaldehyde Dehydrogenase (in the mitochondria). These both use NAD+ (which is needed for normal metabolism) to do their thing, which leaves us with NADH.

So why is drinking bad for you? Cause it inhibits gluconeogenesis, causes lactic acid build up, and damages your cells (yes, you can handle it and drinking in moderation is fine, but molecularly, it is bad).

Cell Damage: acetaldehyde damages pancreas, brain, liver, and GI tract. It also impairs memory and coordination (obviously, lol), and makes you tired (wow who could have guessed that??). Basically, this compound is the reason you feel like shit. Acetaldehyde is bad for you, but you have to make it to get rid of ethanol. Some people (especially those of Asian descent) don't have enough acetaldehyde dehydrogenase. This causes a build up, so they feel worse and get that nice red face when they drink.

Lactic Acid Build Up: okay so remember all that NADH we made to break down ethanol? It's making us have a bad NADH to NAD+ ratio. We really need that NAD+ to accept an electron and allow us to make ATP (energy). So how can we make more of that? We are going to convert pyruvate (made from breaking down glucose) to lactate. What does lactate cause? LACTIC ACIDOSIS! That is bad.

Inhibition of Gluconeogenesis: do you know what you do when you haven't eaten in a little while? You make glucose (gluconeogenesis). You can make glucose from all kinds of shit, isn't that cool? One of these things is called oxaloacetate. When you have no NAD+, you convert oxaloacetate to malate. You can't make glucose from that. The high NADH to NAD+ ratio also inhibits the gluconeogenesis dehydrogenases needed to make glucose. What I'm getting at here is hypoglycemia (low blood sugar) because you have no usable glucose and you can't make any.

So why is this bad? Well, because you don't have glucose, but your cells are still working (and getting damaged :() you need to give some energy to them to function. This comes in the form of ketone bodies. This is really only an issue for heavy drinkers, but over time and with increased frequency, drinking can lead to ketoacidosis.

But yeah, the reason you feel bad after drinking is mostly due to how toxic acetaldehyde is. That's what causes head ache, nausea, and memory problems (from all the damage it does to those cells). So no, drinking more won't get rid of a hangover, and hair of the dog does not work. Eating food helps though, so you can finally have some glucose to work with.

Now some more notes:

Fatty Liver: this is going to be more prevalent in heavy drinkers, but it happens because you convert DHAP to glycerol-3-phosphate. G3P can combine with fatty acids to make triglycerides, which can go live in the liver and cause hepatosteatosis (fatty liver). This is also bad.

Methanol (CH3OH): this is also called wood alcohol, and can most commonly be drunk via bootleg liquor. Your body uses the same enzymes to break it down, but this time it is making formaldehyde and fomic acid. Fomic acid causes ocular toxicity (aka going blind) and brain damage. So make sure you trust whoever you get your bootleg liquor from, okay?

Ethylene Glycol (OHCH2CH2OH): this is antifreeze. Same enzymes again, but you get glycoaldehyde. This then becomes oxalic acid and glyoxylic acid. These cause lactic acidosis and calcium oxalate formation, which crystalizes in the kidneys, causing renal failure.

Final note: your body can handle drinking, like 1-2 drinks per day. I'm not your mom, so do whatever you want, but at least now you know why you feel like shit as your friends hold your hair back so you can puke in the shitty bar toilet :)

[m34tgr1nd3r]

The internet brainrot has finally consumed me. I was driving the other day and saw an advertisement that was formatted like a shitpost and I laughed at it. It was this.

(photo taken at a red light guys, I'm a good driver)

I mean, come on, you can't tell me this doesn't look like something that would be posted online as a joke.

The font, the 4 exclamation points, the "in stock" being one word, the low quality antifreeze image, the bright red text, it all comes together perfectly to form the most perfect image.

[laughmyaortaoff]

What if instead of perfume we spray ourselves with antifreeze

[its-me-im-bumblebee]

Guy eating ice cream in the snow

Some random person: You’re eating ice cream? How are you not cold?

The guy, shoveling a spoonful of ice cream into his mouth: It’s anti-freeze flavored.

[padowski109]

Did you know that, if your antifreeze isn't up to the task this winter, your engine block could actually crack? That's one reason to have your antifreeze checked: http://www.4performanceunlimited.com/blogspot/blog.php?id=7547073655225295577/without-good-antifreeze-this-johnsburg

#checkantifreeze #antifreeze

[ceptemzorpus]

this is so cool

have you guys noticed how often benrey is "found" throughout the series? just shows up when he wants, good for him.

[protex3com]

PROTEX3 is dedicated to more than just making antifreeze, our mission is to provide unmatched value through coolants that meet Original Equipment Manufacturer (OEM) requirements. Our coolants maintain the high quality established during the initial vehicle conception process. Engineered to combat overheating, corrosion, and protect against freezing, PROTEX3 antifreeze coolants offer comprehensive protection. This dedication not only optimizes vehicle performance but also enhances its durability, reflecting our commitment to superior automotive care.