#Adaptive immunity

[dr-afsaeed]

A liver-centric help circuit revives CD8⁺ T cells via IL-27

Nature Immunology, Published online: 08 July 2025; doi:10.1038/s41590-025-02204-9 Effector CD4⁺ T cells restore antiviral CD8⁺ T cell function in the liver by licensing Kupffer cells via CD40–CD40L interactions. This triggers IL-27 production and reprograms the hepatic immune environment. This liver-intrinsic pathway of T cell help is relevant for chronic hepatitis B virus infection and may apply…

[kamalkafir-blog]

Developmental trajectory and evolutionary origin of thymic mimetic cells

Animals C57BL/6 mice were maintained at the Max Planck Institute of Immunobiology and Epigenetics. Foxn1−/− (ref. 27), Foxn1:cre52, Rosa26-LSL-EYFP53, Foxn1:mCardinal54, Ascl1fl/fl (ref. 55), Foxn1:BlFoxn4, Foxn1:CmFoxn4, Foxn1:CmFoxn138 and Foxn1:Fgf720 transgenic mice have been described previously. The Foxn1:Bmp4 transgene was created by T. Schlake and B.K. by inserting a cDNA fragment…

[stripejournals]

Innovations in Vaccine Design and Immunology

Innovations in Vaccine Design and Immunology: A Comprehensive Review

Introduction

Vaccination has been one of the most integral elements of public health for so many years, which greatly reduced the burden of infectious diseases. Rapid progress in science and technology has brought along innovative changes in the designs of vaccines, changing immunology. This article focuses on recent developments that were brought forward through contributions from microbiology, virology, and cell biology.

Vaccine Innovations: Development and Review Articles

The last few review articles on vaccine development have indicated that over the past decade there was a trend away from the conventional vaccines toward next-generation vaccines. From the live-attenuated and inactivated vaccines it led to novel approaches such as recombinant subunit vaccines, mRNA vaccines, and viral vector vaccines. Such breakthroughs in genetic engineering and immunological understanding have been driving these advances.

Key innovations include:

mRNA Vaccines This employs synthetic messenger RNA, able to instruct cells to produce antigens that induce the proper immune response.

Nanoparticle-based vaccines: nanoparticles with application for improved delivery and antigens stabilizing to attain better immune responses.

Personalized Vaccines: Vaccines designed according to the genetic identity of an individual to tackle diseases.

Make your text human

Contributions from Microbiology case reports and publications

Vaccine design requires a significant input from microbiology, because the knowledge of pathogenic mechanisms of microorganisms helps to identify the targets for the vaccine. The recent microbiology case reports have shed light on pathogen-host interactions, antigenic variability, and antibiotic resistance, which are useful in vaccine strategy.

Staphylococcus aureus vaccine development: Recent studies involving the virulence factors and immune evasion of S. aureus lead to promising antigens for vaccine development. 

Tuberculosis Research: Advances in understanding Mycobacterium tuberculosis pathogenesis have motivated the development of enhanced vaccines such as M72/AS01E.

Virology Research Articles and Blogs

Rapid progress has been achieved in vaccine development through research in virology regarding the newly emerging and re-emerging viral threats. Publications and blogs abound regarding breakthroughs against viruses, like SARS-CoV-2, HIV, and influenza.

Notable findings include:

COVID-19 Vaccines: The mRNA vaccines (Pfizer-BioNTech, Moderna) are the epitome of integrating virology research with vaccine innovation through rapid development and deployment.

HIV VACCINE CHALLENGESDespite having passed decades since its identification, the highly mutating nature of HIV still poses a challenge and thus demands the development of broadly neutralizing antibodies.

Universal Influenza Vaccines: Epitopes of the virus are conserved and targeted and vaccines could be designed that provides long-term immunity against most strains of influenza.

Immunology Publications and Blogs

Immunology research underpins mechanisms through which vaccines provide protection. This has made publications and blogs available, including those on topics like immune memory, optimization of adjuvants, and T-cell activation.

Highlights include:

New adjuvants are AS03 and MF59. They act in the modulation of innate as well as adaptive immune response for better vaccine efficacy.

T-Cell-Based Vaccines: An understanding of the cytotoxic T-lymphocyte response has driven vaccines for intracellular infections, including malaria and certain malignancies.

Immune evasion mechanisms: Informed vaccine design based on the mechanism of immune avoidance by pathogen

Cell Biology Journals: Contributions to Vaccine Design

Cell biology journals have offered critical insights pertaining to the cellular processes, whose importance informs vaccine development. Particular areas related 

to antigen processing and presentation, signal transduction, and the cell response to vaccination have emerged more frequently.

For example:

Dendritic Cells as Vaccine Targets: Exploiting dendritic cells to present antigens directly to T-cells has been a focus of cancer vaccine research.

Cellular Uptake Mechanisms: Knowing how cells internalize nanoparticles will help design effective vaccine delivery systems.

Conclusion

The synergy between microbiology, virology, immunology, and cell biology has catalysed innovations in vaccine design. The integration of interdisciplinary research continues to enhance our ability to combat infectious diseases, paving the way for personalized and universally effective vaccines. As highlighted in review articles, newsletters, blogs, and research publications, the future of vaccinology is poised for unprecedented advancements.

References

A comprehensive list of microbiology, virology, and immunology publications, blogs, and newsletters would be appended here to support the findings discussed.

[petpetisy]

Can a Dog Catch Parvo Twice in 2024? Shocking Truth!

Canine parvovirus is a highly contagious and potentially deadly virus. It mainly affects young puppies. Dogs that get over parvo usually build strong immunity. But, new strains can make them sick again. So, can a dog catch parvo twice? It’s important to know how this virus works and its effects on a dog’s immune system. Table of ContentsKey TakeawaysWhat Is Parvo?Susceptible BreedsDuration of…

[djcgold]

Top Immune Boosting Foods for Fall

Discover the power of fall's immune-boosting foods. Strengthen your defenses and stay healthy during the season. Learn more here.

As the leaves change color and the air turns crisp, we welcome the fall season. But along with its beauty, autumn also brings an increased susceptibility to illnesses like the common cold and flu.  Overview of Immunity Understanding the Immune SystemImmunity and its Cyclical BehaviorBest Fall Immune Boosting FoodsApples SquashPumpkinSweet PotatoesPomegranatesNuts and SeedsFinal…

[bennetsbonnet]

I'm always baffled when I see Pride and Prejudice (1995) held up as the gold standard for adaptations of the novel and encounter claims that it is completely 100% book accurate apart from (mainly said in jest, I know) the scenes of Mr Darcy bathing, fencing and diving in the lake because, while the appreciation for damp Colin Firth suggests we did in fact watch the same series, perhaps we did not read the same book...

While a very very good period drama, Pride and Prejudice (1995) does unfortunately miss the mark on several points. Mr Collins is not a short, greasy middle-aged man; there is far too much Wickham; we miss out on a lot of Mrs Bennet's rivalry with Lady Lucas as well as her reaction to Elizabeth's engagement to Mr Darcy and in my opinion, the biggest disappointment of all, is the handling of the Rosings arc.

Proposal aside (which is to me practically perfection) we miss out on the hilarious misunderstanding between Darcy and Elizabeth of her telling him where she takes her daily walks in hopes he will avoid her (as she believes their dislike to be mutual) while Darcy takes it as an invitation to walk with her (much to Elizabeth's frustration). Instead, we merely see a brooding Mr Darcy on horseback encountering Elizabeth and just... wordlessly riding off?! An interaction which looks all the more peculiar given Colonel Fitzwilliam's hints, upon paying a first visit to Hunsford Parsonage, that Darcy has spoken much of her and Elizabeth wondering aloud why Darcy keeps staring at her. That particular scene makes both of them look a bit stupid, as Darcy hears that Elizabeth might not have such a fond opinion of him yet still proposes and Elizabeth gets a hint that perhaps he doesn't think as ill of her as she wishes him to...

And then the ending is also always a disappointment to me, as the lovely dialogue between Darcy and Elizabeth post-proposal is almost entirely omitted, in favour of more time spent earlier in the episode on Wickham and Lydia. By the time the proposal occurs, there's not time for much more than a protracted double wedding. Sigh.

Listen, there's a lot to enjoy and I am not immune to the charms of a damp man dressed in period costume (or even less...) BUT let's also be realistic about its shortcomings and acknowledge that nothing will ever compare to the wit and charm of Jane Austen's masterpiece.

[pascalscoffin]

Can’t wait to be able to enjoy this show without y’all fucking yapping about how it’s not an exact remake of the damn game

[official-english-major]

One of my favorite subtle details in Epic is how, at the start of Wouldn't You Like, you would expect Odysseus to be on his absolute highest guard after all the unexpected hardships throughout the trip and the conversation he just had with Eury. And yet when a mysterious voice from the trees says "I must say, what a brilliant speech you gave," you can practically HEAR the smirk in Odysseus's voice as he asks "who goes there?"

Bro is exploring a strange island while his crews' lives are in danger, but he also LOVES receiving a compliment on his yapping skills

[clannfearrunt]

U can look into sea cucumber toxins but watch out. You might shatter some crucial underlying assumptions you were making with regards to fantasy cephalopod society epidemiology

[fisherrprince]

Hii i wanted to ask about ur thoughts on duskwights and their specbio? they are so neglected in lore which makes me so sad since they are so cool in concept, subterranean elezen!!!

THERE ARE SO FEW DUSKWIGHT I THINK THEYRE SO COOL THOUGH ! Also anon this has been sitting in my inbox because I got bored of drawing xiv when it was sent but im back. Hey. anybody wana play

ANYWAYS. I like to think that on most levels elezen are very similar if not the same, as Gelmorra was said to be founded centuries and centuries ago and the wildwood returned to the forest A While ago - even with the sped up creation magic induced speciation happening on Eitherys they did not have a ton of time to become completely different. More like reversion vs continued adaptation. Duskwight skin tends to be less saturated, their eyes tend to be lighter and reflect light, their ears are canonically way stronger and can hear echoes and I think super high pitches like bats. The fastest way to distinguish wildwood from duskwight is their tails and whiskeriness. Their whiskers are usually longer and thicker (and there’s more of them!) because they’re used more often, but it also means they’re much more sensitive and get uncomfortable in the wind and crowds easily. Some of them trim their whiskers if they choose to live above ground. Duskwight tails are much more unique than wildwood tails - instead of being a single unicorn-like shape they can have a ton of variation. Many of them are split at the tip, sometimes down to the base, and they can have patterns and flat moth wing-like shapes and even whiskers tucked in between the fibers! This leads to them being much less reticent to losing their tails, as it’s a unique and sometimes important part of them.

[dr-afsaeed]

Tumour-associated vasculature in T cell homing and immunity: opportunities for cancer therapy

Nature Reviews Immunology, Published online: 27 June 2025; doi:10.1038/s41577-025-01187-w The vasculature that forms in tumours and supports tumour growth is abnormal and limits T cell entry into tumours. Here, the authors review how the tumour vasculature acts as a barrier to effective antitumour immunity and the therapeutic strategies to overcome this. Summary Tumor vasculature, critical for…

[fluffypotatey]

Like. I know that Newt is strong. Obviously he is. But he's physically built so differently from Thomas and Minho and Gally and even Frypan, almost all the other surviving Gladers, so losing a fight to him would have to be so funny and so embarrassing at the same time.

Imagine being some 6 foot plus WCKD guard in full body armor with an automatic weapon and you get your shit rocked by a 5'10 teenage boy who looks like he weighs a buck ten soaking wet.

Newt puts a guard in a joint lock and Thomas is just talking to them like, "Just give us your access card, buddy. Trust me, you don't want it to go down like this. Gonna be real embarrassing for you. You're a big, tough guy, and he is made of nothing but beef jerky and granola bars."

i feel like with how the Gladers wrestle constantly, Newt’s learned some tricks on how to beat guys with bigger build than him. and he’s a nimble dude who can slip through your grasp which annoys the fuck out of Gally because he finds the tactic “Avoid” cheating

there are no ground rules for their wrestling tho so everybody ignored it when he complained

[evil-jennifer-hamilton-wb]

Learning about Eukaryotic operons, clunky and limited as they are. Yet another prokaryote W!!!!!!!!!!!!!!!!! C. elegans dreams of directly chained genes regulated by a single promoter, it dreams of easily accessable ribosome binding sites, it dreams of cas-like operon mediated adaptive immunity (I actually know nothing about C. elegans immune system idk what it's operons do)

[ruvviks]

coming up with zombie apocalypse stories is always fun because you can just say whatever and people will just have to take your word for it

[sunshinechay]

15 Day BL Challenge! Part 2!

Day 19: If you could turn any Non-BL show into a BL, which would you choose?

Part 1 Part 2

I’m going to have to quietly admit that I haven’t watched a whole lot that wasn’t BL or a douyin drama in last year haha. This year has not been good for my brain and so the lower brain power shows tend to be what I go for most often.

However after thinking about it for a while, I did think of a few that I would love to see a BL version of it.

The first one is a Chinese short drama called Forever Love

A very short summary is a woman became blind following an incident that also killed her father. She is left to pick up the pieces of both her life and her father’s company, all the while completely unaware that her fiancée and best friend are having an affair (and also are the ones who killed her dad). She wants to figure out who killed her father and her new bodyguard decides to help her with that. Bodyguard was also there the night her father died but she doesn’t realize that until after she recovers her eyesight. A very convoluted but fun (imo) plot ensures and ends happily with girl and bodyguard getting together and fiancée and best friend dealt with. It’s very soap opera esque and I would kind of love a gl version. Please give me hot lady bodyguard and heiress falling in love please haha.

Another is an old one but I still have the urge to see it turned into a BL

Itazura na Kiss: Love In Tokyo is a show that I love despite how kind of bad is. (The Japanese version is the best one. I will die on this hill). I think it would be an interesting thing to adapt, not just as a BL but in a more present twist (the age of social media would make Kotoko’s life even worse istg). Yes I know their relationship is very toxic but have you meet me? I like my BLs like I like my nuclear waste. Toxic and fucked up.

There are probably a lot of older Shojo mange/anime/shows that would be fun and also better if made into BL or GLs honestly (stares very pointedly at Boys Over Flowers. It would be better as a BL, I said what I said!).