#1-test cyp

[axsteroidsus]

Buy 1-Test Cyp 100 USA, A Complete Powerhouse for Bodybuilding

1 Test Cyp 100, which contains the active substance Dihydroboldenone Cypionate (100 mg), is regarded as a dihydrotestosterone derivative and a synthetic androgen, an anabolic steroid drug. Dihydroboldenone is a testosterone derivative that shares structural similarities with Primobolan (Methenolone), except for the methyl radical at position 1, which was necessary to give Primobolan its oral bioactivity. This has had a few modifications. Primobolan has ten times the anabolic and androgenic qualities of dihydroboldenone, which is a more potent steroid due to the lack of a methyl radical at position 1. Buy 1 Test Cyp 100 USA for cutting because it does not provide flavoring and bears no water weight. Dragon Pharma produces this med, which is good for dry muscle mass growth. For more click: https://axsteroids.com/injectable-steroids-2113/1-test-cyp-100-48339.html                     

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o2h discovery Hiring Research Associate - ADME: MSc/M.Pharma in Microbiology/Biotechnology Are you a skilled professional with a background in Microbiology or Biotechnology? Join o2h discovery as a Research Associate - ADME and contribute to cutting-edge drug discovery projects. Located in the vibrant city of Cambridge, UK, o2h discovery offers a dynamic and collaborative work environment for talented individuals. About o2h discovery o2h discovery is a leading biotech company specializing in integrated drug discovery services. We partner with global pharmaceutical and biotech companies to accelerate their research and development processes. Our state-of-the-art facilities and expert team provide comprehensive support across chemistry, biology, and ADME. Job Role and Responsibilities Research Associate - ADME Location: Cambridge, UK As a Research Associate in the ADME department, you will be responsible for: Performing all ADME assays with precision and efficiency. Developing methods and collecting data using LC-MS/MS and other modalities (Absorbance/Fluorescence). Supporting new assay development for ADME activities. Analyzing data from enzyme activities (GraphPad Prism, MS-Excel) and MS data (Sciex). Compiling reports and interfacing with collaborators. Coordinating with third-party collaborators for PK studies (animal models). Conducting day-to-day testing and profiling of compounds in cells/protein-based assays. Drafting reports, documenting experiments, and presenting results within the lab and in various forums/meetings. Working closely with other biology group members involved in screening, cell biology, protein biology, and ADME. Contributing to group activities (like ordering, stocking, and follow-ups). Qualifications and Skills To be considered for this role, you should have: An MSc/M.Pharma in Microbiology/Biotechnology. 1-4 years of experience with LC-MS/MS, HPLC, and bio-analytical studies. A solid understanding of laboratory tools, techniques, and methods. Hands-on experience with general biotech laboratory equipment (cell-culture lab, in-vitro and ADME lab). Practical experience with cell culture techniques (established cell lines) and ADME assays (microsomal stability, plasma stability, solubility, permeability, CYP inhibition assays, plasma protein binding assays). The ability to overcome technical challenges and exercise sound judgment under pressure. High self-motivation to initiate projects and work independently under aggressive deadlines. Strong technical knowledge with exceptional attention to detail. Excellent personal rapport and the ability to engender trust and respect. The ability to work well as part of a small focused team and build relationships. Exceptional organizational skills that thrive in a fast-paced and vibrant team environment. Positivity, focus, and a winning mentality allied with kindness. Curiosity, energy, creativity, and bravery with a strong desire to help build the o2h culture. [caption id="attachment_66270" align="aligncenter" width="930"] o2h Group Recruitment Alert[/caption] How to Apply If you meet the qualifications and are excited about this opportunity, we encourage you to apply. For more information about the job role, responsibilities, and application process, please visit o2h discovery Careers.

[personalsteroids]

Rumored Buzz on Anadrol

I'm sure they say that when it comes to measurement and energy that Anadrol will be the king, but like I stated I felt like I received a lot more away from Dianabol.

AND… I like my BBB Way of life, (Babes, Beer and Blow) been dwelling it for 3 decades. Does 1 really need to stick to just the babes for that cycle and pct? or does it not make any difference at at acceptable sum?

I lent a gym Close friend some $$$ and he repaid me with two hundred 10mg Oxandrolone and 200 10mg Stanozolol. Any solutions on what amount or which or each which i could securely insert to my current HRT and any other terms of what to incorporate, cautions or your common fucking hella mad Knowledge.

We’ve manufactured all probable endeavours making sure that the data supplied here is accurate, up-to-day and complete, even so, it shouldn't be treated in its place for Skilled professional medical suggestions, diagnosis or treatment. Practo only supplies reference supply for popular info on medicines and doesn't assure its precision or exhaustiveness. The absence of the warning for any drug or mix thereof, really should not be assumed to indicate that the drug or combination is safe, powerful, or suitable for any provided affected person.

I’m on trt at 100mg examination cyp every week. I’m just coming off a small surgical procedure that held me out in the gymnasium for approximately two months. I’m all set to get again just after it and lean out for summertime. I have a bottle of deca 250mg/ml.

Este ciclo es recomendado para aquellos que quieren perder peso y acelerar el metabolismo. Para las mujeres que quieren ganar masa muscular, la dosis puede ser aumentada hasta los 20 miligramos.

Algunas investigaciones apuntan a que el anavar tiene un efecto anabólico que es muy beneficioso en la ayuda a la ganancia de masa muscular, principalmente para aquellos que se están iniciando en el uso de medicamentos anabolizantes, y también para las mujeres, gran parte del público que consume el anavar.

Reality: With a great food plan and moderate dosage it received’t cause you to bloated, it’s nevertheless 90% diet! Most bodybuilders again in the 1970’s used Deca Andriol testocaps up until about fourteen times out from a contest before dropping it and took no anti-estrogens all through cycles. The late Sergio Oliva utilised solely Deca/Dbol for a contest prep staple and was a best bodybuilder!

I think we a solo will Have you ever feeling like rubbish. I'd personally use take a look at with it, the 19-nor compounds contend With all the dht receptors and you can genuinely really feel like crap without the need of check in there

Go on working with Arimadex or Aromasyn all through your 2 wk wait before beginning Clomid, and keep on with it even though on Clomid and Individually speaking, I would go a week past your Clomid with it.

Christian Vasquez (November 5, 2012): “Sustanon 250 is the greatest steroid I’ve utilised. It's got substantially elevated my toughness and dimensions although not offering me any Unwanted side effects. I'd advise it to any individual who wants to bulk up devoid of stressing about drinking water retention or other regular side effects.”

It’s also important to bear in mind the doses for Women of all ages are unique and frequently decreased than Those people for guys. Girls start to knowledge physique mass gains at two hundred-400mg of Deca drugs weekly and While the aspect-outcomes are generally significantly less extreme for Females on Deca, they're able to nonetheless be serious.

Following we get to the cousin of Deca, NPP (Nandrolone Phenylpropinoate) NPP is basically what test prop will be to Testosterone Enanthate; it’s a shorter version of nandrolone that packs pretty a punch at just 200 mg/week.

La vida media de Anavar es de aproximadamente 8 horas. Se recomienda dosificar este compuesto dos veces al día.

[deity187]

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[scleroticstatue]

It's potentially all foods — there's a link to kidney failure when Central America started using it heavily on sugar cane — but specifically gluten first because 1. Humans don't actually digest gluten, the bacteria in your guts do, 2. Glyphosates are shown to cause chelation in minerals, specifically cobalt — i.e., it prevents them from being properly digested — which is one of the testing markers for celiac disease, but other mineral deficiencies can cause other autoimmune diseases like microcephaly, which is also linked to gluten intolerance, 3. Glyphosates suppress CYP enzymes in plants which in turn regulate our vitamin A1 amount, which is also linked to Celiac's, 4. Glyphosates have been shown to reduce digestive enzymes along with killing your digestive bacteria, which means that the food you eat isn't digesting as well and on the way out it's tearing the microfolds in your digestive tract, and since gluten is a massive molecule (12,000-130,000 DA, compared to sugar that's 180 DA (not 180,000 just 180) or even bigger stuff like starch at 1,000-10,000 DA), it's more likely to get wedged on what is essential an open wound and more likely to cause damage.

Gluten is most likely the figurative canary in the coal mine for almost all allergies. It's not researched enough to be actionable, considering how many protections Big Ag has in place, but there's definitely enough research for anyone who's read the studies to be like "oh. Okay. Okay."

Personally I think the medical profession should stop asking "what normal God-made nutritious foods that have been staples of the human diet for 5,000+ years do people need to completely cut out of their diet to be healthy" and start asking "how do we fix what's making people's body not tolerate wheat"

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10 Reasons 1-Testosterone is a stimulating Steroid

AAS Analysis:

10 Reasons 1-Testosterone is a stimulating Steroid

 1-testosterone (dihydroboldenone), aka DHB, may be a steroid which has been growing in popularity recently but isn't new the bodybuilding world. DHB isn't a testosterone-based compound; it's merely the 5alpha reduced sort of Equipoise (boldenone). DHB acts during a much different way than standard Testosterone or EQ. DHB is that the dihydrotestosterone (DHT) version of equipoise like DHT is to Testosterone. 1-Test is one among the foremost potent present steroids to be isolated. From 2002-2005, 1-Testosterone was being sold as a supplement until being added as a category III drug in Jan. 2005. During this short 3 yrs, a number of these supplements sold with good success albeit the oral bioavailability isn't very high. Supplement companies were using 1-Testosterone in an oil solubilized softgels attached to an undecanoate ester (think Andriol/ Lymphatic delivery) also as Transdermal solutions/gels at the time. Both of those delivery methods have some positive effects but, the injectable preparations are quite simply, simpler. In most cases, DHB is attached to the cypionate ester. There are not any legit prescription DHB injectable preparations available, therefore the only options are all from underground labs (UGL) sources. Always use caution when using anything from UGLs. UGLs aren't regulated and are available with more risk for contamination. For this text, we are getting to focus mainly on 1-Testosterone Cypionate. Here are ten reasons why 1-testosterone may be a steroid that I find to be very interesting.

 1.) DHB has an anabolic to androgenic ratio of 200/100. As compared, testosterone's A: A ratio is strictly 100 (100:100), and Deca Durabolin is rated at 125: 37, so DHB is twice as anabolic as testosterone and almost twice as anabolic as Deca. However, let's not forget that rates given to anabolic androgenic steroids (AAS) are often misleading. DHB is extremely minimally androgenic. Side effects like aggression and vital sign increase are getting to be less likely to occur than with other steroids. Compared to other compounds, DHB is taken into account very mild, but this is often all relative to the dose used. 1-Testosterone doesn't cause significant stress on the kidneys or other organs. 1-Testosterone is understood to yield lean quality tissues gains with little to no bloat with low side effect potential.

2.) DHB is extremely anabolic and doesn't aromatize, which suggests it should yield nice lean muscle gains. DHB is more anabolic than testosterone, equipoise, and Deca Durabolin. Since there's no aromatization to estrogen, there's no got to worry about estrogenic side effects like gynecomastia or water retention. Beat all, DHB are often an excellent pre-contest hormone since it'll offer you minimal water retention. 1-Testosterone Cyp is great for helping to take care of muscle while on a contest diet, might be used for a lean bulk with relative ease by running it at moderate doses, or are often used with aromatizing compounds like Testosterone, Dianabol, or MENT for an all-out bulk when combined with a diet that reflects those goals.

 3.) Unfortunately, Injectable DHB is understood to return with prominent post injection pain (PIP). This happens after the injection, and that I believe this might be since 1-Testosterone is an irritating substance on its own. This will even be experienced with a number of the transdermal solutions. The PIP may cause many to avoid DHB and miss out on the potential benefits. From my experience, the PIP seems to vary greatly from person to person. Almost like how some have PIP with steroids attached to the propionate ester. PIP also can vary counting on which underground lab is manufacturing the answer. Most ordinarily you'll find DHB dosed at 100-150mg/ml. The 150mg/ml is typically getting to cause more PIP than the 100mg/ml. to assist reduce the PIP, try diluting the DHB with another steroid or sterile oil like Grapeseed oil (sterilized). Heating the oil with a hot pad before doing the injection can sometimes help also as doing all of your injection slowly. Using less volume with each injection can sometimes help take a number of the snap at also, so rather than doing 2ml on Mon. and Thurs. you'll try doing 1ml Mon., Tues., Thurs., and Friday.

  4.) Another potential negative drawback is that the volume of oil needed to offer the user a robust effect. 1-Testosterone is extremely almost like Primobolan when it involves the way they're dosed mg/ml and therefore the volume of oil that has got to be wont to reach the specified effect. Both DHB and Primo are typically dosed at 100mg/ml. Most users notice the simplest results once they recover from 400mg per wk. This suggests you're injecting an honest little bit of this painful oil into your muscles weekly. For many, this may prevent them from using this steroid.

 5.) Curiously enough , DHB has some thermogenic properties, almost like trenbolone, mainly regarding sweating and in some cases insomnia. DHB gives very nice strength gains without hurting appetite so it is often a really nice bulker. Although it's going to share its name with equipoise or testosterone, users consider DHB more as trenbolone's baby brother. I personally desire this is often overstating the facility of DHB. Yes, it's an excellent anabolic, and that i desire it's a stronger compound than Primobolan but yet definitely milder than tren. The PIP makes it somewhat difficult to use in most cases, but I even have personally had 1-Test Cyp that had little or no PIP a time or two, and in those cases, it wasn't an inconvenience in the least to use. Meager side effects overall aside from the potential injection site pain and a small increase in blood heat. If you'll find a 1-Testosterone Cyp with little PIP that's from a trusted source, it's worth using both within the offseason and in contest prep counting on your diet and your goals. This compound could easily be implemented in either situation with great success. a bit like all steroids, DHB is suppressive, so a radical post cycle therapy (PCT) should be implemented unless you're on Testosterone replacement.

 6.) 1-Testosterone is one among the few steroids which will be taken in oral form, transdermal solution, or in an injectable preparation. As stated above to experience the foremost benefits the injectable preparation is best except for some, the transdermal 1-Testosterone are often a pleasant addition or are often utilized by women in lower doses. Here is what a number of the standard doses were when DHB was being sold as a supplement before being placed on the list as a schedule III drug. When it had been dosed orally and packaged in an oily solution in gel cap form the oral dosing was 100-250mg daily. Transdermally, 75-100mg was applied daily. I personally enjoyed the transdermal version and ran it up to 200mg daily this version is hard to return by nowadays. Starter doses with the injectable cypionate version would be 100-200 mg added to TRT dose of test. Confine mind this is often a really mild dose, and personally, I felt just subtle changes from this dose. If you won’t to running only 1-200mg / wk of Testosterone for TRT then added in 200mg of DHB, you'd probably notice a touch effect, except for a bodybuilder running much higher doses, this is able to probably get to be doubled or tripled to note truth potential positive anabolic effects of this compound. Women have used this steroid at low doses like 25mg daily of the orally. Typically, the oral dosages are prepared much higher per cap. Injectable dosing for ladies is around 10-20mg per wk. Any use of this compound by a female could still very easily because masculinizing effects.

 7.) When DHB is combined with moderate to higher doses of testosterone an AI should be used. This is often because 1-Testosterone features a high binding affinity to the androgen receptor which suggests there's an honest chance more testosterone goes to be displaced. This might very likely increase estrogen and free testosterone to above normal levels. For instance, for instance a bodybuilder.

 is using around 400-500 milligrams (mg) per week of DHB with long ester testosterone dosed at 4-600mg/wk. Some guys may use 4-600mg of Testosterone by itself with no AI (I wouldn't recommend this, but some people escape with it) but when the 1-Testosterone is employed in conjunction with an equivalent dose of testosterone more of the testosterone are often aromatized which yields a better estrogen level.

 8.) DHB does aromatize but only at a really low level. It’s not fully understood how. It’s speculated that the body could also be potentially inserting a covalent bond on its own at carbon-4. Even still estrogen related sides are usually very mild to non-existent with this compound by itself. If employed by itself or stacked with non-aromatizing agents, it shouldn't cause noticeable estrogenic side effects, like lethargy, low libido, or depressed mood. For this reason, it's an honest idea to stack some testosterone with it. Males got to have estrogen to function optimally and by keeping a minimum of a replacement dose of Testosterone in with the DHB cycle should accomplish this. The added testosterone will give the cycle another androgenic kick. The side effects aren't bad in comparison to stronger compounds like trenbolone, and are probably more in line with the side effects which will arise with Equipoise and/or Primobolan. As stated above, support supplements, blood work, and a full post cycle therapy (PCT) should be used in the least times.

 9.) 1-Testosterone may be a Dihydrotestosterone (DHT) derived steroid. I even have heard a couple of people say it's not a Testosterone base, DHT base, or 19-Nor base but something different. This is often not correct. 1-Testosterone is what DHT is to Testosterone to Boldenone (EQ). Boldenone may be a Testosterone Derived Steroid and Dihydroboldenone is that the DHT derivative of Boldenone. This is often also why it's the classic DHT type results, Hardening, Strength, little to no water retention, low to no estrogenic side effects.

10.) 1-Testosterone is often an irritating substance to the skin. This has been known to not only cause some irritation within the transdermal formulas but also the PIP which most realize it for. One other thing that I found to be interesting was that some users may experience a small burning during urination from this compound. I personally noticed I felt like I had to urinate more frequently while on 1-Test Cyp once I got over 5-600mg/wk this is often also where I noticed the slight stinging or burning sensation. It had been very mild and honestly had I not been really listening to the small details I’ll have overlooked this.

  In closing, my personal opinion on 1-Testosterone is that it is often a superb tool for bodybuilders who don't mind doing frequent, voluminous injections. It works great during a cut phase also as a lean mass building phase. Overall the side effects are relatively mild but to not be taken without any consideration. The anabolic effects are significant if you'll tolerate moderate or higher doses of this anabolic. 400mg+ is where you actually start to ascertain some changes. Do I feel it compares to Tren? No I don’t, but I do desire it works better than both Primobolan and EQ mg per mg, but EQ is simpler to use at higher mgs. The PIP is often severe in some cases and varies from person to person and batch to batch. I hope you guys enjoyed this text to shut I’m getting to offer you a couple of example setups. Here are a couple of hypothetical scenarios, this is often an example of how i might found out differing types of cycles with DHB after having used 1-Test Cypionate quite a couple of times.

  Example 1: 1-Test Cyp as a part of a cutting stack would look something like this. For theoretical purposes, here is what a cut stack may appear as if while utilizing 1-Test Cyp for a male bodybuilder : 300mg of Test prop per wk (100mg on Mon, Wed, Fri), 3-450mg of 1-Test Cyp(100+150mg on Mon, Wed, Fri), with 300mg of Tren ace/wk (100mg Mon, Wed, Fri) and perhaps a lower dose of oral Winstrol or Anavar (25-50mg) on training days only. Ancillaries: Exemestane 12.5mg on Mon, Wed, Fri.

  Example 2: 1-Test Cyp as a part of a bulking cycle would look something like this. 600mg of 1-Test Cyp (200mg Mon, Wed, Fri), 600mg of Test E or C (200mg Mon, Wed, Fri), 300mg of NPP (150mg Tues and Thurs), 25mg of Dianabol on training days.

GH- 2 IU pre-workout / 2 IU post workout

Ancillaries: Exemestane 12.5mg a day.

  LLEWELLYN, W. (2017). ANABOLICS (11th ed.). S.l.: MOLECULAR NUTRITION.

1-Testosterone (dihydroboldenone)

[cameron-brook-blog]

1-Testosterone Cypionate / Dihydroboldenone DHB Powder

1-Testosterone Cypionate / Dihydroboldenone DHB Powder

1-testosterone (dihydroboldenone), or DHB for short, is an anabolic steroid that has some unique properties of interest to bodybuilders. Interestingly, in spite of the fact that the name can be confusing, in no way is DHB testosterone. In fact, it is simply the 5alpha reduced form of Equipoise (boldenone), which acts in a completely different way. Therefore, you can think of it as a…

[dieveticord-blog]

Full SportsTime 2019 Women's Internationals: England ENG v France FRA

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[wayne62d54464600-blog]

Listing of Different Anabolic Steroids and Anabolic Steroid Benefits And Drawbacks

We thought it would certainly be helpful to assemble an useful checklist of anabolic steroids medications typically used for muscle building and bodybuilding. In the name of accomplishing a particular athletic objective, a lot of individuals are searching for particular listings of artificial anabolic steroids in different groups as well as objectives. Below are most, otherwise all, of the significant China anabolic steroids (https://chinarawsteroids.com) steroids on the market, (omitting all of the different brand name options), and also their key objective when used as performance boosting materials. Some are used for Message Cycle Therapy (PCT) at the end of a cycle utilizing a rough efficiency enhancement supplement. Get steroids online here. Checklist of Anabolic Steroids and What They Do Anadrol-- utilized for bulking, taken orally Anavar-- preferred by female professional athletes, used for lean gains & reducing Clenbuterol-- weight-loss, weight loss & cutting Clomid-- liked as post cycle therapy Cytomel-- weight loss & cutting Deca Durabolin-- used mostly for bulking yet can likewise be utilized in reducing Dianabol-- bulking Equipoise-- performance enhancement: speed & toughness Halotestin-- toughness as well as aggression Human Growth Hormone: bulking, muscle growth Insulin-- efficiency improvement: endurance, muscular tissue manufacturing Lasix-- cutting, reduce water retention & swelling Methyltestosterone-- dental testosterone/ made use of for toughness as well as dimension Nolvadex-- short-term upkeep as well as cholesterol decrease PCT Omnadren-- muscle mass gains in the offseason & in some cases cutting Primobolan-- high nitrogen retention, lean muscle & cutting Sustanon-- reduced consumption needs, lean muscle & cutting Cypionate-- testosterone substitute Enanthate-- different testosterone substitute Propionate-- increased pureness different testosterone replacement Testosterone Suspension-- Super increased purity different testosterone substitute Testosterone-- the key male growth hormone, advertises muscular tissue size as well as toughness Trenbolone-- effective stamina as well as size promotion-- High toxicity Winstrol-- Many prominent steroid of perpetuity. Made use of for toughness, dimension, as well as cutting. Less poisonous than Trenbolone Caroline Hatton, Ph.D., as well as a doping prevention consultant, claimed "The key in making prohibition lists work is they prevent finiteness. Instead of listing each prohibited drug individually, they detail whole medicine courses and name particular medications only as instances. This is to prevent users that take designer drugs from stating they didn't damage a particular rule because the medicine that they utilize was not noted." To put it simply, they open up the jaws of the catch as extensively as possible in order to capture as many transgressors as they potentially can. However it's reasonable, after all- how can we validate these people's too high incomes if they do not have a heck of a great deal of active job to do? So, whether any thing on the above listing of anabolic steroids for body building is actually named on the WADA checklist, you can be sure that the stipulations would certainly cover any one of them. Even if they do not- the rules are versatile sufficient to engulf any person captured doping. Each sporting activities organization which adopts this "Code" is likewise in charge of the enforcement of it via drug screening and also charges for non-compliance. Numerous significant sports organizations, like Major League Baseball (MLB), the National Football Organization (NFL), and also the National Basketball Organization (NBA), have yet to embrace WADA's "Code.". While this may be shocking, it stands to reason that were any one of these major sports companies to adopt the code, it would suggest huge decreases in the performance requirements of their groups and also gamers. It would certainly likely hurt the appeal of these games. Legal Recommended Steroids Catalog. Boldenone Undecylenate: $1200/KG. Testosterone Enanthate: $690/KG. Sustanon 250( S250): $1050/KG. Nandrolone Decanoate: $1900/KG. Stanozolol( Winstrol): $1700/KG. Contact solution individuals to address your inquiries and obtain even more solution. Most safe Steroid-- www.safeststeroid.com. If you're searching for non-liver toxic oral steroids, you most likely need to look into steroid different supplements. These are without a doubt the safest steroids as they have virtually absolutely no side effects. The safest real steroid for body building is thought about by a lot of to be Anavar. You may aslovisit www.safeststeroid.com to learn more. Listing of Prescription Steroid Names Bodybuilders Usage. Afro-- Methyltestosterone. Agovirin Depot. Anabolic DN. Anabolicum Vister. Anadrol. Anadrol 50. Anadur. Anatrofin. Anavar. Andractim. Andriol. Andro-Cyp-- Testosterone Cypionate. Androderm. Androgel. Andropen 275. Arderone 100/200-- Test Enanthate. Boldebal-- Equipose. Bolfortan. Cabaser-- Cabergoline. Cheque Decrease. Choragon-- H.C.G. Clomipheni citrate-- Clomid. Contrapasmina-- Clenbuterol. Cytomel Tabs-- Cytomel. Danocrine. Deca Durabolin. Delatestryl. Deposterona. Depot Testosterone. Dianabol (steroid road name: Dbol. Diandrol. Dimethyltrienolone. Dinandrol. Durabolin. Dynabol. Dynabolan. Eltroxin-- L-Thyroxine. Emdabol. EPO. Equilon 100. Equipoise. Ermalone. Esiclene. Estandron. Fherbolico. Finaject. G. chor. "Endo"-- H.C.G. Genabol. Gonadotraphon-- H.C.G. Halodrol. Halotestin. Chaos. Histerone inj-- Test Suspension. Hydroxytest. Libriol. Madol. Masteron. Masteron Enanthate. Mediatric-- Methyltestosterone. Megagrisevit Mono. MENT. Methandriol. Methandriol Dipropionate. Methosarb. Methyl-1-Testosterone. Methyl-D. Methyltestosterone. Methyltrienolone. Miotolan. MOHN. Myagen. Nandrabolin. Nandrolone. Nandrolone Phenylpropionate. Nebido. Neo-Ponden. Neotest 250. Nilevar. Norandren 50, 200. Omnadren. Ora-Testryl tabs-- Halotetin. Orabolin. Oral Turinabol. Oranabol. Orgasteron. Oxandrolone. Oxymetholone. Parabolan. Perandren. Physex-- H.C.G. Primobolan. Primobolan Depot. Primoteston. Promagnon. Prostanozol. Proviron. PSGAG. Retabolil-- Deca. Riboxifen-- Nolvadex. Rodozol-- Cytadren. Roxilon. Roxilon Inject. Sanabolicum. Spectriol. Spriopent mite-- Clenbuterol. Stanozolol. Sten. Steranabol Ritardo. Sterandryl Retard. Sterobolin-- Deca. Superdrol. Sustanon. Sustanon 250. Synovex. T. cell pharm-- Nolvadex. T. Streuli-- Examination Propionate. T3-- Cytomel. Tamaxin-- Nolvadex. Tamofene-- Nolvadex. Examination 400. Testoderm. Testolent. Testopel. Testosterone. Testosterone CHP. Testosterone Cypionate. Testosterone Enanthate. Testosterone Heptylate. Testosterone Propionate. Testosterone Suspension. Testoviron. Testred Cyp-- Examination Cypionate. The Clear. The Lotion. THG. Thioderon. Transdermal Testosterone. Tren. Trenbolone. Trenbolone Enanthate. Tri Trenabol. Tribolin. Ultandren-- Halotestin. Winstrol. Winstrol Depot. Leading Steroid Brand names( Significant kind alphabetically). Alpha Pharma. Balkan Pharmaceuticals. Bayer. British Dispensary. British Dragon. Concentrex. Crazybulk. ElitePharm. Geneza. Kalpa Pharmaceuticals. LA Pharma. Organon. Puro-Labs. Sciroxx Labs. Trademark Pharmaceuticals. Sopharma. SP Laboratories. If you need to know even more regarding branded firm for steroid completed item and also Underground Laboratory( UGL) House made steroid, you may obtain even more info here ： Anabolic Steroids-- Drug Quality vs. Under Ground Laboratory (UGL) \ The Checklist of Unlawful Steroids\ The checklist of prohibited steroids is so big that it would be impossible to checklist as well as describe all of them below, regrettably. That's because there are 192 of them. Yes, that is a surprisingly high number \ We have actually edited thousands of thousands of words on the subject of steroids below, and even we really did not recognize there were that many sort of unlawful steroids in the world \ The International Olympic Committee (IOC) as well as the United States Olympic Board (UOC) stand with over 625 official sports companies around the world \ They have actually jointly embraced the World Anti-Doping Company's (WADA) main performance enhancing steroid "Code" which prohibits 192 of these efficiency enhancing compounds, formulations and also techniques of use. Article By steroidly. Edited by Wumei Technology, All Civil Liberty Reserved \ WADA Listing of Performance-Enhancing Medicines\ Efficiency enhancing drugs can be added and also deleted from the checklist by WADA more or less at will- however not every one of the certain prohibited substances are named explicitly \ As you can visualize, this can make it difficult to recognize which are allowed as well as which are not \ Yet, customarily, the policy makers are not worried regarding the experience of actual people who need to live under their guiding lights. Have a look at the best bulking cycles as well as product here \ The Effects of Steroids\ While all of the steroids on our list of anabolic steroids names will vary in residential properties to some degree, it is fair to state that they all have residential or commercial properties in common- both positive and also unfavorable \ Anyone seeking to acquire steroids must take into consideration all of the list below variables; \ Their specific performance demands\ Sex comparability\ Compound toxicity vs individual health and wellness\ Familiarity with the sought substance as well as similar medications\ Every little thing on the above checklist of steroids will certainly or may: \ Create positive results \ Advertise the appearance of trimness\ Promote muscular tissue development\ Enhance muscle strength as well as rate\ Trigger unfavorable effects \ Trigger water retention\ Advertise kidney and liver issues\ Negatively impact high blood pressure as well as cholesterol\ In the marketplace for Steroids\ Research the drug you want completely. Know it upside as well as downwards. Know just how much it sets you back in every form. Know where in the world it is legal and also unlawful \ Learn more than one steroids blog to discover solutions- those are the only people that will certainly speak honestly concerning just how to utilize steroids for performance enhancement- qualified individuals take the chance of shedding their jobs, liberty, as well as credibility if they advise any person to use steroids for these reasons \ If you wish to know the most effective anabolic steroid on the whole, it's Winstrol. Hands down. Yet that doesn't mean it's the most effective for your requirements as well as your biology \ If you're seeking to purchase steroids online, you need to (read with fantastic focus) totally as well as completely research study every little thing from the medicine itself to the vendor to the place and also reputation of the resource \ Prior to you order steroids online, do lots of research study on the full listing of anabolic steroids. It is the very best means to find the very best anabolic steroid for you \ Who Invented Steroids\ The very first steroid artificially generated was testosterone. In August of 1935 it was initial manufactured by Adolf Butenandt as well as G Hanisch. He won a Nobel Peace Reward for his job \ The Russians were the first to utilize them for performance-enhancement in sports. Their success had the UNITED STATES Olympic team's doctor develop his very own anabolic androgenic steroids with a group of drug store \ The initial steroid was called Dianabol Methandrostenolone \ Why would a Physician recommend steroids? Dianabol was prescribed for melt victims. Various other steroids are utilized to cause male puberty, deal with cancer and also HELP, along with promote muscle mass development \ Today names of steroids for swelling and allergies show up as a few of one of the most regularly used prescription steroids by medical professionals \ Are anabolic steroids lawful? In the majority of nations, steroids are lawful with a prescription for medical as well as restorative purposes. They are illegal for bodybuilding \ When did steroids end up being prohibited in the USA? Anabolic androgenic steroids were contributed to the dangerous drugs function as schedule III medications in the Anabolic Steroids Control Act of 1990 \ Ben Johnson's questionable success at the 1988 summer season Olympics triggered the discussion about whether steroids need to be lawful or not \ If you want to boost your efficiency without buying illegal steroids, attempt purchasing from this list of legal steroids \ Steroids For Women\ Anavar, Clenbuterol and Winstrol are the most effective steroids for ladies. Most steroids create side effects that are also hazardous for women bodies \ The most vital steroid shots for bodybuilding are Trenbolone, Deca Durabolin, Dianabol, Winstrol, and Testosterone \ The oral steroids listing consists of Anadrol, Anavar, Clenbuterol, Dianabol, Trenbolone, and also Winstrol \ If you're trying to find a checklist of bodybuilders and also celebrities who make use of steroids, click on this link. Arnold Schwarzenegger, Ronnie Coleman and also Dorian Yates were one of the most well-known \ With the variety of brands, variations as well as alternatives out there, it's tough to compile an absolutely detailed checklist of anabolic steroids offered today, yet we covered a lot of the top steroid names right here.

[my-steroid-raw-powder]

Buy Testosterone Cypionate powder 58-20-8 For Bodybuilding Supplements Use

Raw Testosterone Cypionate (Test cyp) powder basic Characters

Product Name: Testosterone Cypionate powder

CAS number: 58-20-8

Molecular Formula: C27H40O3

Molecular Weight: 412.6047 g/mol

Melt Point: 98.0-104.0°C

Color: White crystalline powder

Storage Temp: Store at 8°C-20°C, protect from moisture and light

Testosterone Cypionate Powder

Testosterone Cypionate powder, commonly referred to as “Test cyp powder”.

Testosterone Cypionate is a synthetic testosterone, is a long-acting version of the parent hormone testosterone with an attached cypionate ester to delay its release into the body. Testosterone is the most potent, naturally occurring androgen that is formed in the human body. It is responsible for characteristics specific to males and their sexual traits. It mainly used in clinical treatment without testosterone disease or class testosterone, cryptorchidism, functional uterine bleeding, menorrhagia, endometriosis, uterine fibroids, menopausal syndrome, metastatic breast and ovarian cancer, a pituitary dwarfism, senile osteoporosis, aplastic anemia, etc.

Testosterone Cypionate is a kind of difficult to get a long-term testosterone, Cypionate can effectively increase muscle mass and strength, is a little more efficient than Testosterone Enanthate, is very popular in the testosterone, but its water more, and relative to other synthetic reaction of the drug than may relatively more, clinical general effective dosage of 200-1000 mg every week, a lot of people use more 2000 mg/week,, of course, this is not very safe.

Testosterone Cypionate can only be used in an injectable form and is often used to treat conditions such as low Testosterone. More than 20 million people in the United States have some form of low testosterone, which can seriously reduce the quality of life. Symptoms such as muscle mass and loss of strength, decreased libido and sexual performance, increased body fat and low energy levels are common features of low testosterone. In addition, neglect of low testosterone can be a gateway to many serious conditions such as alzheimer’s disease, diabetes and osteoporosis. Most men find injections every seven to ten days, with a total of 100mg to 250mg per injection to completely eliminate the problem.

Testosterone Cypionate powder Benefits

Testosterone Cypionate comes with the benefits and effects of all testosterone steroids; the ester attached to it simply controls the release time and in this case results in a slower release steroid that will suit people doing longer cycles.

Some of the big benefits you will experience when using Test Cypionate at a higher dosage for performance and bodybuilding purposes include:

Boosts protein synthesis, nitrogen retention, IGF-1 hormone, and keeps the body in a prime anabolic state to promote muscle growth, fat loss and, endurance muscle repair.

Encourages the growth of lean muscle and the loss of fat making it ideal for a bulking cycle.

It’s also ideal for cutting cycles as it helps retain lean muscle while fat being burnt, while also maintaining strength levels which can often otherwise suffer during heavy dieting phases.

Enhances athletic and muscular performance with increased endurance and the ability to workout longer and harder without tiring as quickly as you normally would, ensuring faster progress towards your results.

Recovery is enhanced with an increase in red blood cells getting greater amounts of oxygen and nutrients to the muscles.

All of these benefits and effects are possible with Testosterone Cypionate, but your specific dosage, workout and diet routines will greatly determine just how powerful these effects will be. Your age and genetics also play a role in how this (and any other) steroid will affect you.

Your results are not necessarily going to be the same as the next guy at the gym using the exact same steroid cycle. Testosterone Cypionate provides the power to deliver exceptional results to those who are determined to use the steroid to its maximum potential.

Testosterone Cypionate powder Dosage

Whatever your goals are, your Testosterone Cypionate can be tailored to meet them and this is a steroid that is considered one of the safest to use at bodybuilding doses where muscle gain is the main goal. Regardless of your experience level, the recommended dosage frequency is twice weekly injections to maximize and maintain your blood levels of the steroid.

This is a versatile steroid that can effectively be used from as low as 250mg weekly for beginners, right up to 1000mg per week for advanced users, with intermediate users often settling for 500mg to 700mg weekly for a very effective muscle growth dosage while still being able to control side effects.

While it might be tempting to increase the dosage to above 1000mg to increase gains, doing so also brings about heightened estrogen and androgenic side effects that are not worth the trade-off for the extra gains and dosing this high is not recommended.

Testosterone Cypionate powder Cycles

A Testosterone Cypionate cycle can be designed for cutting or bulking and this is a versatile steroid that stacks very well with almost any other steroid out there whether it is used as a primary compound or for testosterone support at lower doses.

Beginner Testosterone Cypionate Cycles

A 12 week cycle with a dosage of between 300mg and 500mg weekly and with no other steroids included makes this a safe, simple and easy to administer testosterone-only cycle for a beginner wanting to gain quality lean mass with minimal side effects.

Testosterone is considered the safest steroid for a beginner to start with until you can determine your own individual response, and then consider adding other steroids into a stack as intermediate and advanced users do.

Intermediate Testosterone Cypionate Cycles

If you’re at the intermediate stage then you will likely want to combine Testosterone Cypionate with other steroids in a stacked cycle, such as Deca-Durabolin and Dianabol.

A typical cycle of this type would include Testosterone Cypionate at 500mg weekly and Deca at 400mg weekly for 12 weeks, with Dianabol providing a kickstart for the first 4 weeks only at 25mg daily.

The primary benefits of this stack for intermediate users is for making big gains in strength and bulk while making use of three of the most popular and widely used steroids in a tried and proven stack cycle.

Advanced Testosterone Cypionate Cycles

Advanced users will often look at using Testosterone Cypionate as a supportive compound only while relying on much more powerful steroids to take on the role of the primary anabolic compound for muscle gains.

An example advanced cycle of 12 weeks includes 200-300mg weekly of Testosterone Cypionate and 600mg per week of Trenbolone Enanthate. This cycle avoids the side effect of water retention because Testosterone Cypionate is taken at a low enough dose that aromatization can be avoided, and Trenbolone does not aromatize and convert to estrogen; therefore this advanced cycle comes with the added benefit of no estrogen related side effects.

Testosterone Cypionate injectable recipes

Test Cypionate 200mg/ml @ 100ml Recipe

20 gram Testosterone Cypionate powder (18.18ml)

2ml BA (2%)

20ml BB (20%)

59.82ml Oil

Testosterone Cypionate 250mg/ml @ 100ml cooking recipe:

25 gram Testosterone Cypionate powder

3ml BA (3%)

15ml BB (15%)

33.25ml EO

30ml GSO

Buy Testosterone Cypionate Powder

There are many testosterone cypionate suppliers available both online and in physical stores around the globe. However, you need to be very careful if you need to get a high-quality drug that will guarantee you quality results by the end of your cycles. Not every testosterone cypionate manufacturer you find online is genuine, some are just there to make money, and they don’t care about the results you will get after taking your dosages. Before you buy testosterone cypionate, first do your research. Make sure you understand how the testosterone cypionate supplier works before you make any order. Read different customer reviews as well as looking at the company ratings.

We are the leading testosterone cypionate supplier and manufacturer in the region. Our website is user-friendly, so you can easily make your order using your smartphone, tablet, or desktop from the comfort of your home or office. We always make sure that we deliver all the products within the shortest time possible. You can buy testosterone cypionate powder in bulk or just enough for your bulking or cutting cycles. Remember, no matter how easily you can get the drug, don’t start taking it without your doctor’s guidance.

Reference [1] Nieschlag E, Behre HM, Nieschlag S (26 July 2012). Testosterone: Action, Deficiency, Substitution. Cambridge University Press. pp. 315–. ISBN 978-1-107-01290-5. [2] Nieschlag E, Behre HM, Nieschlag S (13 January 2010). Andrology: Male Reproductive Health and Dysfunction. Springer Science & Business Media. pp. 442–. ISBN 978-3-540-78355-8. [3] Becker KL (2001). Principles and Practice of Endocrinology and Metabolism. Lippincott Williams & Wilkins. pp. 1185, 1187. ISBN 978-0-7817-1750-2. [4] Kicman AT (June 2008). “Pharmacology of anabolic steroids”. British Journal of Pharmacology. 154 (3): 502–21. doi:10.1038/bjp.2008.165. PMC 2439524. PMID 18500378. [5] Hoberman J (21 February 2005). Testosterone Dreams: Rejuvenation, Aphrodisia, Doping. University of California Press. pp. 134–. ISBN 978-0-520-93978-3.

[kratompointt]

Kratom: Uses, Effects, Hazards

Towards this aim, we employed untargeted metabolomics to decide which alkaloids vary in content material across business kratom merchandise. We then remoted those relevant alkaloids and as compared their biological consequences in vitro, inclusive of activity on the µ-opioid receptors kratom capusles and inhibitory consequences on CYP isoforms involved within the metabolism of opioids and different tablets. Our remaining goal with this take a look at become to capture the range of business kratom products being hired via US clients and to evaluate (based on vitro studies) the potential implications of this variability in terms of protection and efficacy.

Commercial kratom merchandise may be divided into  chemotypes with differing alkaloid profiles

We performed untargeted metabolomics evaluation of more than 50 commercial available kratom merchandise (Table S1) to gain a international contrast of chemical composition. A principal thing evaluation (PCA) plot of the resulting records (Fig. 2) reveals what look like  different groupings of the information. It become of interest to decide which chemical constituent(s) have been liable for those differences. To achieve this, we tested loadings and volcano plots (Fig. 3) and determined that the height region of a constituent with m/z of 401.2064 and retention time of two.70 various throughout the 2 groups.

This constituent was isolated and identified as the recognised kratom oxindole alkaloid speciofoline (three, Fig. 1) ([M + H]+  = 401.2071, Δ = 1.7 ppm) based totally on contrast of NMR, ECD, and mass spectrometry information with literature values23,24,25,26 (Table S2, Figure S1 and S2). Several other ions had been also found to vary in content material across the samples (Fig. Three), and primarily based on their similar mass disorder to indole alkaloids27, are possibly other extra minor alkaloids of kratom. Structures of those other putative alkaloids had been now not determined in this study.Genetic variations do no longer appear to explain the observed chemotypes in business kratom samples There are 10 related species in the Mitragyna genus6, such as Mitragyna speciosa (Korth.) Havil., Mitragyna diversifolia (Wall. Ex G. Don) Havil., Mitragyna hirsuta Havil., and Mitragyna rotundifolia (Roxb.) Kuntze. While these species can be distinguished by way of morphological characteristics in raw plant fabric, contamination or misidentification ought to occur all through collection and could not be outstanding in powdered fabric which include that used in this take a look at. The dramatic differences in alkaloid amount in diverse kratom samples validated in Table 1 and Fig. 4 led us to invite whether the samples pronounced to be Mitragyna speciosa might be exclusive species or strains of Mitragyna.

[paleorecipecookbook]

How Mold Exposure Can Hurt Your Gut Health

If you’ve encountered mold, either from a water-damaged building or contaminated foods, you’ve likely encountered mycotoxins—toxic byproducts of mold. They’re common environmental toxins, and they have adverse effects on many body systems, including the gastrointestinal tract.

While you’ve probably heard about the respiratory symptoms that can follow mold exposure, research indicates that mycotoxins can cause serious problems for your gut, as well. Read on to learn how mycotoxins impact gut health and the microbiota and what you can do to help restore your gut health if you’ve been exposed.

You know that mold exposure can cause major respiratory symptoms, but did you know it can hurt your gut, too? In this article, I explain how mold can hurt your GI tract and give my recommendations on how to get your gut healthy again. #optimalhealth #wellness #chriskresser

Did You Encounter Mold?

Unfortunately, mold exposure is far more common than we might expect. In the United States alone, 43 percent of buildings have current water damage, and 85 percent have past water damage. (1) Even homes that haven’t suffered water damage can house mold if indoor humidity levels are too high. Contaminated crops, including grains, as well as some fermented foods and dairy, can also carry mycotoxins.

Mycotoxins may play a crucial role in the development of chronic inflammatory response syndrome (CIRS), a complex, multifaceted illness. If you have CIRS brought on by mold exposure, you could be feeling any number of a wide range of symptoms: (2)

Malaise after exerting yourself

Weakness or fatigue

Memory problems

Headaches

Lightheadedness

Shortness of breath and other respiratory issues

Chronic abdominal problems

If you’re experiencing the symptoms above and you think you may have encountered mycotoxins, I recommend you get tested for CIRS. You can read more about CIRS and how to get tested in my article “5 Things You Should Know about Toxic Mold Illness.”

More about Mycotoxins

Mycotoxins are not molds, but rather the toxic compounds produced by specific types of fungi such as:

Aspergillus

Fusarium

Stachybotrys, or black mold

While a few mycotoxins have useful applications—the antibiotic penicillin is a toxin derived from Penicillium fungi, and the mycotoxin citrinin is used to produce cheese, sake, and miso—the vast majority of mycotoxins are harmful and capable of causing disease in humans.

The most frequently encountered harmful mycotoxins (which can ingested through consuming contaminated foods, inhaled or otherwise absorbed) are:

Trichothecenes

Fumonisins

Ochratoxins

Aflatoxins

Mycotoxins have a diverse array of harmful effects on the body. They are carcinogenic, mutagenic (capable of altering your DNA), and estrogenic (therefore triggering hormonal imbalance) and impair the normal function of the immune system, kidneys, liver, and nervous system. Emerging research indicates that mycotoxins also interact with the gut microbiota.

How Mold Can Hurt Your Gut Health

Mycotoxins produced by mold impair gut health on a structural and functional level. They disrupt the balance of beneficial and pathogenic bacteria in the gut, increase intestinal permeability, interfere with nutrient absorption (causing malnutrition), generate oxidative stress and inflammation, and increase your susceptibility to bacterial, viral, and parasitic gut infections.

It Changes Your Gut Microbiota

Mycotoxins can increase levels of harmful gut bacteria and deplete beneficial microbes. Research has found that exposure to deoxynivalenol (DON), a fumonisin mycotoxin, significantly increases levels of Bacteroides in the gut; also, a high proportion of Bacteroides is associated with inflammatory bowel disease (IBD). (3) Ochratoxin reduces levels of Lactobacillus reuteri and bifidobacteria; the reduction of beneficial lactobacilli and bifidobacteria decreases the intestinal production of short-chain fatty acids, leading to impaired gut immunity. (4)

Mycotoxins also promote the growth of pathogenic bacteria. In animal studies, ochratoxin ingestion increases the growth of a family of bacteria that includes Staphylococcus and Listeria. A combination of aflatoxins and fumonisins enhances the growth of Shiga-toxin-producing Escherichia coli, a type of E. coli that causes diarrhea, UTIs, and bloodstream infections. (5, 6)

It Can Lead to Leaky Gut

The intestinal epithelium—tightly packed epithelial cells that line the walls of your intestines—acts as a barrier to block the entry of pathogens, toxins, and foreign antigens into the bloodstream. Trichothecenes, fumonisins, and aflatoxins interfere with a protein that links epithelial cells together, weakening this barrier; they also decrease gut-protective mucin production and lower IL-8, a cytokine that assists with pathogen removal. (7) These effects increase intestinal permeability, causing leaky gut and rendering the gut vulnerable to infection.

It Can Cause Weight Loss and Even Malnutrition

Mycotoxins can damage your intestinal villi. Intestinal villi are small, finger-like projections that extend into the small intestine. They increase the surface area of the intestine and provide more pathways for nutrient absorption. Trichothecenes and ochratoxins degrade intestinal villi. (8) Shortened intestinal villi increase the risk of malnutrition by decreasing surface area available for nutrient absorption.

The mycotoxin deoxynivalenol (DON), a member of the trichothecene family, also blocks several nutrient transporters in the GI tract, including the D-glucose/D-galactose sodium-dependent transporter (SGLT1) and the D-fructose transporter (GLUT5). (9) Inhibition of these transporters impairs the absorption of carbohydrates and can promote small intestinal bacterial overgrowth (SIBO), malnutrition, and weight loss.

It Could Increase Oxidative Damage

People who have been exposed to mycotoxins require higher levels of antioxidants to combat free radical damage in their GI tracts. (10) Mycotoxins induce the production of reactive oxygen species (ROS), which oxidatively damage intestinal cells. (11)

Mold Increases Your Susceptibility to Gut Infections

Those who develop symptoms caused by mold often experience a variety of gastrointestinal issues, including gut infections. Mycotoxin exposure may directly increase your susceptibility to bacterial, viral, and parasitic gut infections by decreasing your intestinal immunity.

In animal studies, ochratoxin triggered viral gut infections and strengthened the virulence of intestinal parasites. In chickens, Fusarium decreases populations of CD4+ and CD8+ cells (helper T cells), increasing the risk of coccidiosis, an intestinal disease that easily spreads from bird to bird. Furthermore, the effectiveness of antiparasitic drugs is reduced by high levels of circulating mycotoxins, suggesting that mycotoxin exposure should be addressed first before attempting to treat parasitic infections. (12)

These Factors Can Worsen the Harmful Effects of Mold

Several factors may exacerbate the harmful effects of mycotoxins on your gut, including diet, antibiotic use, stress, exposure to other environmental toxins, and genetic background.

A diet high in grains, conventional dairy, and other processed foods that can become contaminated exponentially increases your exposure to mycotoxins. Mycotoxins can get into the food supply at various points in its production and distribution. For instance, grains sitting in storage, waiting to be transported or processed, can become damp and then moldy with mycotoxin-producing fungi. This is especially true with industrially farmed crops that are grown and harvested in vast quantities and then stored for long stretches of time before going to market.

Also, we know that antibiotic use and stress disrupt the gut flora, which can reduce the microbiome’s capacity to bind and detoxify mycotoxins. Exposure to other environmental toxins in water-damaged homes or other buildings—such as bacteria, Actinomycetes, endotoxins, and microbial volatile organic compounds (VOCs)—creates further toxicity in the GI tract. Finally, people with variants in CYP genes may be at an increased risk of mycotoxin-induced dysbiosis and intestinal epithelial damage; this is due to impaired processing of mycotoxins by cytochrome p450 enzymes in the liver. (13)

If You Have SIBO or IBS, Mold Exposure Might Make Things Worse

The gastrointestinal tract serves as the primary interface between ingested mycotoxins and the rest of the body.

Fascinatingly, researchers have discovered that mycotoxins and the gut microbiota engage in bidirectional crosstalk that ultimately influences the structure, function, and health of the gastrointestinal tract.

They have learned that while a healthy gut microbiota can bind and metabolize some ingested mycotoxins, mycotoxins can also alter the microbiota and reduce its natural detoxification capacity. This means that patients with pre-existing gut issues such as irritable bowel syndrome (IBS) and SIBO may be more severely impacted by mycotoxin exposure than people with a healthy gut microbiota, due to changes in their gut bacteria that reduce their capacity to process mycotoxins. (14)

Here’s How to Restore Your Gut Health after Mold Exposure

The first step in treating the side effects of mycotoxins is to stop your exposure to the mold in the first place and test your home for mold. Then you can focus on restoring your gut health.

Take Probiotics

Beneficial gut bacteria bind mycotoxins and prevent their absorption in the small intestine. Probiotic strains with mycotoxin-binding properties include Lactobacillus rhamnosus, L. plantarum, L. casei, and Propionibacterium freudenreichii. (15, 16, 17) If you’re trying to reduce your total mycotoxin load and detox, I encourage you to supplement with a multispecies probiotic containing these strains. Saccharomyces boulardii is another beneficial mycotoxin-binding probiotic that has been found to be effective in treating ochratoxin-exposed animals. (18)

Use Activated Charcoal or Another Sequestering Agent

Sequestering agents are compounds that bind mycotoxins in the GI tract and prevent them from being recirculated through the liver and GI tract. They help reduce the number of mycotoxins to which GI cells and microbes are exposed. Cholestyramine, activated charcoal, and bentonite clay are potent binding agents that can reduce the bioavailability of mycotoxins in the gut. (19, 20) However, these can cause constipation. I would only recommend them if you tend to have loose stools or you suffer from diarrhea. If you have constipation, chlorella also has mycotoxin-binding properties and may be a better option for you.

Switch to a Low-Mold Diet

Your diet can be a significant source of mycotoxins, especially if it is centered around grains, dairy, and other processed, packaged foods. Experimenting with a low-mold diet will reduce the amount of mycotoxins entering your GI tract and protect your intestinal epithelial cells and the gut microbiota. Here are some simple guidelines for implementing a low-mold diet.

You Should Avoid These Foods Entirely

Avoid high-sugar fruits:

Pineapple

Mango

Banana

Melons

Oranges

Grapes

Excess sugar fuels fungal overgrowth in the gut, a condition that often accompanies toxic mold illness; avoiding these fruits temporarily will starve and facilitate the eradication of fungal pathogens. I also recommend steering clear of packaged and processed foods, most grains, and fermented foods. And, of course, don’t consume foods that contain mold or yeast, such as:

Cheese

Alcoholic drinks

Processed and smoked meats

Edible fungi

Dried fruits

You Can Eat These Foods, but Only in Moderation

Consume moderate amounts of:

Rice

Quinoa

Buckwheat millet

Teff

Gluten-free oats

Potatoes

Sweet potatoes

Legumes

Squash

Low-sugar fruits such as apples and berries

Eat These Foods Whenever You Want

You’re free to eat organic and grass-fed meats and poultry, wild-caught seafood, non-starchy vegetables, fresh sprouted nuts and seeds, olive oil, coconut oil, ghee, and butter.

Bone broth, gelatin, and collagen peptides provide easily assimilated amino acids that can help repair damaged intestinal cells, so they’re another great addition to your low-mold diet.

Now I’d like to hear from you. Do you suffer from gut issues? Were you exposed to mold, or do you believe you were? Let me know in the comments below.

The post How Mold Exposure Can Hurt Your Gut Health appeared first on Chris Kresser.

Source: http://chriskresser.com November 08, 2018 at 02:36AM

[milesllisa]

English FA Cup News, Stats, Scores - ESPN

Tonights fa cup results - Scottish Cup Fixtures & Results | Scottish Cup| Scottish FA

Culture Secretary Oliver Dowden said coronavirus 'certificates' were being considered as a way of getting people back to larger events in the UK 'in significant numbers'. One of the FA Cup semi-finals at Tonights fa cup results is now being considered as a pilot event in government plans to return fans safely to stadiums, as ministers finalise tonights fa cup results list of Covid test events. Jamie Carragher had the unenviable task of trying to thwart Thierry Henry on several occasions during their careers, as Arsenal's record scorer was quick to remind when as they shared punditry duties.

The Arsenal legend was impressed with the attacking approach that helped Arsenal to torment Tottenham in the final third during their win on Sunday - but has concerns over their uneven season. Events starting with FA Cup semi-finals are pilot schemes for reopening tonights fa cup results and other events in the UK. Boris Johnson will give the green light if successful in June. The FA Cup final could be played in front of 20, fans on May 15 after it was confirmed the Government will use it as a test event in May cyp pave the way for larger crowds at Wembley for the Euros.

Leeds United boss Fz Tonights fa cup results, as a tactician who loves related site little details, will no doubt be aware of how his Yorkshire neighbours made life difficult for the west Londoners in the FA Cup last month.

Want an antidote to the depressing furore surrounding Irish trainer Gordon Elliott?

FA Cup News

Saints were article source of the Premier League earlier this season but a run of just one win in 11 games has led to fears they may be in a relegation battle. Hasenhuttl feels the break may work in their favour. Arteta remains confident that Arsenal are heading in the right direction despite a season of inconsistency which has left them languishing in mid-table for the duration of the season.

Tonights fa cup results Wilder watched the lacklustre Blades lose a fifth game in six against Southampton, producing only two shots on target in a defeat that dealt another huge blow to their survival hopes.

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I can still see him diving forward on the six-yard box to angle his header into the Wembley net, clinching the FA Cup. The former Scotland forward passed away on Monday evening after a battle with illness. He won two First Division titles in and and scored the winner in the FA Cup final. Phil Jones left injury hell at Manchester United is set to continue with the centre back possibly missing the rest of the season due to a long-standing knee problem.

Pep Guardiola's side have already racked up 20 consecutive victories in all competitions. If they continue to win, they could surpass the record winning runs of some outstanding teams. To have impacted two different institutions as Ian St John did is testimony to the great man's talent and warmth.

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Fans will be back at elite sports events from Cu; 17 with 10, supporters allowed at the biggest venues - like Wembley and large Premier league football grounds before the end of the season. Argos AO. Privacy Policy Feedback. FA Tonights fa cup results semi-finals to be part of pilot events for crowd return with up to 4, allowed into Wembley Harvey Barnes eyeing a return from knee injury by the start of May as he looks to help Leicester seal a Champions League place Man United boss Ole Gunnar Solskjaer said he doesn't need trophies to massage his ego but he has failed again after limping out of the FA Cup Bournemouth 2 1 Crawley Redults FT.

Chelsea 3 1 Resuls Town FT. Brentford 1 3 Leicester City FT. Fulham 0 3 Burnley FT. Manchester United 3 2 Liverpool Tobights. Tonights fa cup results 3 0 Sheffield Wednesday FT.

Southampton 1 0 Arsenal FT. Barnsley 1 0 Norwich City FT. Millwall 0 3 Bristol City FT. Chorley 0 1 Wolverhampton Wanderers FT. Southampton 2 0 Shrewsbury Town FT. Barnsley 2 0 Tranmere Rovers FT. Bristol City 2 1 Portsmouth FT. Chelsea 4 0 Morecambe FT. Your password was not recognised. No account? Sign up! By clicking "OK" or continuing to use this site, you agree ta we may collect and use your personal data and set cookies to improve your experience and customise advertising.

To see how, and to learn how to control cookies, please read our Privacy Policy and Cookie Policy. FA Tonigbts. Sport Football FA Cup. Latest News. In the last 2 hours. BBC 9-Apr Big incentive for Gillingham women Kent Messenger 9-Apr Why Leicester City are not overachieving as they offer proof to outsiders Leicestershire Live 8-Apr Where are they now?

EFL chief cautiously optimistic that Sheffield United and Wednesday can kick off next season in front of capacity crowds Sheffield Star 7-Apr FA Tonights fa cup results final vaccine passports would be 'discrimination' and 'wrong', says one former player i News 7-Apr Kelechi Iheanacho shows his love for Leicester City fans with favourite moment selection Leicestershire Live 7-Apr Roker Report Weblog 6-Apr Spurs to have fans present for cup final Enfield Independent websites Vaccine passports Pilot scheme for theatres, tonights fa cup results, sports and nightclubs The Telegraph 5-Apr

[juniperpublisherscasestudies]

Juniper Publishers- Open Access Journal of Case Studies

Accidental Exposure to Docetaxel Overdose - Case Report and Review of the Literature

Authored by Amr Muhammed

Abstract

Since the 1990s, docetaxel plays an expanding role in the treatment of high-risk breast cancer, lung cancer, advanced gastric and metastatic prostate cancer [1,2]. Hundreds of publications have mentioned the diverse range of docetaxel toxicity profile and the increased likelihood of bone marrow suppression, GIT and skin toxicity with dose escalation beyond 100mg/m2 [2]. Despite that, very few authors pointed to cases of docetaxel overdose and proper medical intervention in these cases [3]. This publication aims to point at one of the cases of accidental docetaxel overdose secondary to miscalculation at the clinical pharmacy ward and the medical intervention taken with the case.

Keywords: Docetaxel overdose; Docetaxel toxicity; Chemotherapy overdose; Taxane toxicity; Taxane overdose

Abbreviations: ANC: Absolute Neutrophil Count; CYP: Cytochrome P Enzymes; D: Day; GIT: Gastrointestinal Tract; SCLC: Small Cell Lung Cancer

Introduction

Docetaxel is a hydrophilic semisynthetic analogue of paclitaxel, originally, produced from Taxus Baccata's needles. It facilitates the assembly and stabilization of cellular microtubules through blockage of their depolymerization process. This enhanced stability interferes with their essential arrangement during cell cytokinesis leading to arrest the cell cycle [4].

Docetaxel is metabolized and deactivated by CYP 450 enzymes family, namely, 3A4 and 3A5 then excreted mainly into the bile [5]. The efficacy of the docetaxel detoxifying hepatic elimination depends on several factors such as, the genetic polymorphisms of CYP3A, the concomitant use of CYP3A inducers or inhibitors and Pgp inhibitors that affect Pgp, the membrane transport protein of docetaxel inactive products, in biliary canaliculi [4,6].

Although thousands of publications mentioned and discussed docetaxel related toxicity such as BM depression, GIT and skin toxicity especially patients receiving doses beyond 100mg/m2, the literature lacks any reports discussing the issue of docetaxel overdose and the proper clinical management of such condition [2,3].

Case Report

A 53-years-old male, ECOG-Performance status 1, with a history of refractory Stage-IV SCLC failed on Etoposide-Cisplatin, was admitted to the hospital with grade-3 diarrhoea and fatigue six days post-Docetaxel-Cisplatin infusion. Accidentally, the patient received overdosed docetaxel at 175mg/m2, a total of 280mg on D1, given on 1-hour infusion and dosed cisplatin at 70mg/m2, total dose of 110mg, given on 2-hour infusion post- 2000 c.c. fluid hydration.

At admission time, his physical examination revealed grade-3 diarrhoea, dehydration and neutropenia 0.4x109/L and grade-2 mucositis of the GIT. Liver and kidney function tests were unremarkable. He received adequate IV hydration, broad-spectrum antibiotics; levofloxacin 500mg/IV/24hr and metronidazole 500mg/IV/6hr, GC-CSF factor; filgrastim 5|ig/ kg/day/SC and other measures against mucositis. Five days post admission, his diarrhoea was controlled, and his ANC rise to 3.5x109/L. he kept under observation for another 5 days then discharged from the hospital.

Discussion

Docetaxel is a hydrophilic semisynthetic analogue of paclitaxel is produced from Taxus Baccata's needles. It produces its pharmacological action through stabilization of cellular microtubules leading to cell cycle arrest during mitosis. Thus, docetaxel toxicity and side effect profile are commonly related to tissues with rapid turnover; bone marrow, skin and gut mucosa.

We described a case of accidentally miscalculated docetaxel dose, given in docetaxel/cisplatin combination, in 53-years old male patient with a history of SCLC failed on first-line Etoposide/Cisplatin. He developed grade-3 diarrhoea, grade-2 buccal mucositis, and neutropenia at 0.4x109/L. The patient was hospital admitted and received adequate fluid hydration, broad-spectrum antibiotics and hemopoietic growth factor till improvement and discharge.

Till now, no antidote to docetaxel overdose or a predefined standard of care management to cases with overdose. Thus, monitoring the vital signs, adequate hydration, broad-spectrum antibiotics, GC-CSF and other symptoms directed supportive measures remain the only possible guide for dealing with these patients.

Conclusion

Although docetaxel overdose is a rare medical condition to be seen in current practice, it is still a serious medical condition that needs to be dealt with extreme caution. Since no antidote has been identified to such condition, supportive treatment based on symptoms and guards against neutropenia are the best of care in current practice.

In this case, the early attention to the patient clinical condition, adequate intervention through monitoring of vital signs, enough hydration, use of broad-spectrum antibiotics and GC-CSF factor were enough intervention to facilitate early recovery.

Following this accidental docetaxel-overdose, new restrictions were implemented in the clinical pharmacy and drug preparation unit and chemotherapy ward to prevent such accidents from being happened again.

For more articles in Open Access Journal of Case Studies please click on: https://juniperpublishers.com/jojcs/index.php

[mbimphblog]

GENE EXPRESSION STUDY OF COMPOUND (DEHB) TREATED LARVAE ISOLATED FROM THE Streptomyces rimosus AGAINST THE FUNCTIONAL GENES OF Culex quinquefasciatus Say (Diptera:Culicidae) | UTTAR PRADESH JOURNAL OF ZOOLOGY

The present study aims to test the effect of Streptomyces rimosus-isolated compound (di-2-(ethyl hexyl) phthlate) on mosquito gene expression, namely Cytochrome P450 (CYP450), Glutathione S-transferase (GST), Esterase (EST) and Beta-actin (ACTIN) using RT-PCR and qTPCR. GST, EST, CYP and actin gene nucleotide sequences from Cx. Quinquefasciatus was extracted from a database of NCBIs. In the conserved regions of the mosquito nucleotide sequence, primers were constructed using the web tool Primer3 Input. Mosquitoes were treated with the Streptomyces rimosus isolated drug. Early Twenty Third Instar Cx Larvae. Into the containers, quinquefasciatus were added. Using dimethyl sulfoxide (DMSO) (249 ml water and 1 ml DMSO), concentrations of 2.0 ppm of the compound were prepared; five replicates for treated concentrations were preserved. According to the manufacturer's instructions, complete RNA was extracted using the RNeasy package. Using the QuantiTect reverse transcription package, the total RNA was translated into cDNA. In the final amount, the RT- PCR reaction was 20 μl. The reactions were performed by using gene-specific primers under standardised qRT-PCR conditions. The findings showed that as compared to standard controls, the EST gene showed downregulation. In addition, in contrast to the controls, the GST gene showed differential levels of expression and CYP 450 showed no difference in expression. EST and GST genes are responsible for insecticide resistance, as per previous studies, but the compound-treated larvae showed some up- and downregulation of genes in EST and GST in our study. Clearly, the current study notes that the isolated compound DEHP from S. Rimosus can be used to interrupt the production of resistance to Cx. Insecticide-fighting quinquefasciatus. Please see the link :- https://mbimph.com/index.php/UPJOZ/article/view/1617

[rnomics]

Cells, Vol. 9, Pages 87: Metabolism of Reactive Oxygen Species in Osteosarcoma and Potential Treatment Applications

Background: The present study was designed to explore the underlying role of hypoxia-inducible factor 1α (HIF-1α) in reactive oxygen species (ROS) formation and apoptosis in osteosarcoma (OS) cells induced by hypoxia. Methods: In OS cells, ROS accumulated and apoptosis increased within 24 h after exposure to low HIF-1α expression levels. A co-expression analysis showed that HIF was positively correlated with Forkhead box class O1 (FoxO1) expression and negatively correlated with CYP-related genes from the National Center for Biotechnology Information’s Gene Expression Omnibus (NCBI GEO) datasets. Hypoxia also considerably increased HIF-1α and FoxO1 expression. Moreover, the promoter region of FoxO1 was directly regulated by HIF-1α. We inhibited HIF-1α via #siRNA and found that the ROS accumulation and apoptosis induced by hypoxia in OS cells decreased. In this study, a murine xenograft model of BALB-c nude mice was adopted to test tumour growth and measure the efficacy of 2-ME + As2O3 treatment. Results: Ad interim knockdown of HIF-1α also inhibited manganese-dependent superoxide dismutase (MnSOD), catalase and sestrin 3 (Sesn3) expression in OS cells. Furthermore, hypoxia-induced ROS formation and apoptosis in OS cells were associated with CYP450 protein interference and were ablated by HIF-1α silencing via #siRNA. Conclusions: Our data reveal that HIF-1α inhibits ROS accumulation by directly regulating FoxO1 in OS cells, which induces MnSOD, catalase and Sesn3 interference, thus resulting in anti-oxidation effects. The combination of an HIF-1α inhibitor (2-mercaptoethanol,2-ME) and ROS inducer (arsenous oxide, As2O3) can prohibit proliferation and migration and promote apoptosis in MG63 cells in vitro while inhibiting tumour growth in vivo. http://bit.ly/2u4gtvR