#source: j. jonker

[vanalex]

[unopenablebox]

i'm unshakably certain that someone must have made a "the jopper" joke when both jopping and the 2019 joker movie were big (in the vein of "to the joker this is just a regular car", "to the jonker this is just a regular liquid", and so on)

but unfortunately i can't actually remember ever seeing one, and also jopper is apparently the name for a het ship from stranger things? so my search engine efforts have been useless. thwarted in my hunt for the jopper

[ibaha]

‘Joker’ Looks To Break Worldwide B.O. Record For R-Rated Film, On Its Way To $900M ‘Joker’ Looks To Break Worldwide B.O. Record For R-Rated Film, On Its Way To $900M #Joker ★Source: *https://ift.tt/2ldLEQZ ******************************************************************* In the name of Allah, the Entirely Merciful, the Especially Merciful. AL - FATIHAH 1. [All] praise is [due] to Allah, Lord of the worlds . 2. The Entirely Merciful, the Especially Merciful, 3. Sovereign of the Day of Recompense. 4. It is You we worship and You we ask for help. 5. Guide us to the straight path - 6. The path of those upon whom You have bestowed favor, not of those who have evoked [Your] anger or of those who are astray. 7. AMIN Al - Quran. ******************************************************************* Disclaimer: ========= For copyright matters please contact us at: help.100@yahoo.com ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ 💖💖💖 Sponsor And Donations...$£€₹ PayPal - help.you@aol.com Payoneer - help.you@aol.com Bitcoin - 3QF1JScZAd5qG5BCXBe8UhDZJBA2QUzp8k ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ _a joker video, a joker fan film, a joker toy, a joker music, joker blood smile, joker batman, joker baby, joker best scenes, joker bruce wayne scene, joker breakdown, joker best moments, joker box office, joker bathroom song, ever b joker, block b joker, m.o.v.i.e joker, block b joker reaction, cardi b joker, zona b joker, nicob joker, j.o.b joker, cardi b joker001, block b joker song, joker clips, joker cosplay, joker costume, joker car scene, joker canisters, joker cartoon, joker cop car scene, joker chase scene, joker comparison, joker cringe, c jonker, studio c joker, c kan joker, joker c ops, me pongo joker c-kan letra, joker c ops settings, c kan joker letra, c reel productions joker, me pongo joker c-kan instrumental, c ops joker handycam, joker dark knight, joker death scene, joker dances on stairs, joker dies, joker death, joker dancing on stairs song, joker dance song, joker drawing, d joker gezeg, d joker two face, djoker band, d rockers dance group, d jokers dance group, d.joker gezeg house mix, joker song 8d, official dj d joker, bounty hunter d joker, d&d joker build, joker edits, joker end scene, joker ending song, joker entrance, joker end credits, joker easter eggs, joker ending explained, joker elevator scene 2019, hey joker, e joker trailer, hey joker dj, hey joker dj song, hey joker 2, hey joker 2019, hey joker song dance, hey joker song 2019, hey joker dance, hey joker scene, joker final trailer reaction, joker full movie 2019, joker final scene, joker film theory, joker first trailer, joker face paint, joker film, joker final smash, f zero x joker cup, impractical jokers f, joker ta9t f adam, joker 2 face f16, f o r joker, jay f joker, joker f gamer respeita, joker gaming f, joker ember f, eufab joker f, joker gary, joker gotham, joker gary glitter, joker gaming, joker gas, joker gun scene, joker gas fortnite, joker gary glitter scene, joker gta 5, joker get what you deserve, irfu g joker, max g joker, g shock joker edition, g eazy joker, g shock custom joker, g shock joker original, g shock joker petak, joker hey song, joker hit me, joker harley quinn, joker hospital scene 2019, joker heath ledger, joker hit by car, joker halloween costume, joker highlights, joker half in the bag, joker heist, h joker dj ks, joker interview, joker impression, joker interview scene, joker irs, joker intro, joker in smash, joker ign, joker incel, joker in smash reaction, joker injustice 2, i joker movie, i joker song, i joke, i joke to you, i joke i smoke, i joke joke mo kay badman, i joke i joke i keed i keed, i joke but i don't play - tone-loc, i joke i joke sound effect, i joke i started, joker jared leto, joker joker, joker joaquin phoenix laugh, joker joe rogan, joker jimmy fallon, joker jail scene, joker joaquin phoenix scene, joker justice league, joker joaquin phoenix interview, joker jr, dj joker, dj joker song, dj joker 2019, dj joker gaan, dj joker remix, j joker beyblade, dj joker gezeg, dj joker song 2019, dj joker mix, dj joker ringtone, joker kills murray, joker kills 3 guys, joker kill count, joker kill, joker kills murray reaction, joker kills mom, joker knock knock, joker kiss scene, joker killing scenes, joker kills his friend, k joker rules, s.k joker gamer, October 21, 2019 at 05:16PM by X World

[cancersfakianakis1]

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality

Publication date: 11 June 2018 Source:Cancer Cell, Volume 33, Issue 6 Author(s): Ewa Gogola, Alexandra A. Duarte, Julian R. de Ruiter, Wouter W. Wiegant, Jonas A. Schmid, Roebi de Bruijn, Dominic I. James, Sergi Guerrero Llobet, Daniel J. Vis, Stefano Annunziato, Bram van den Broek, Marco Barazas, Ariena Kersbergen, Marieke van de Ven, Madalena Tarsounas, Donald J. Ogilvie, Marcel van Vugt, Lodewyk F.A. Wessels, Jirina Bartkova, Irina Gromova, Miguel Andújar-Sánchez, Jiri Bartek, Massimo Lopes, Haico van Attikum, Piet Borst, Jos Jonkers, Sven Rottenberg Inhibitors of poly(ADP-ribose) (PAR) polymerase (PARPi) have recently entered the clinic for the treatment of homologous recombination (HR)-deficient cancers. Despite the success of this approach, drug resistance is a clinical hurdle, and we poorly understand how cancer cells escape the deadly effects of PARPi without restoring the HR pathway. By combining genetic screens with multi-omics analysis of matched PARPi-sensitive and -resistant Brca2-mutated mouse mammary tumors, we identified loss of PAR glycohydrolase (PARG) as a major resistance mechanism. We also found the presence of PARG-negative clones in a subset of human serous ovarian and triple-negative breast cancers. PARG depletion restores PAR formation and partially rescues PARP1 signaling. Importantly, PARG inactivation exposes vulnerabilities that can be exploited therapeutically.

Graphical abstract

Teaser

Gogola et al. show loss of poly(ADP-ribose) glycohydrolase (PARG) confers resistance of BRCA2-deficient tumor cells to PARP inhibition by restoring PAR formation, controlled DNA replication fork progression, and the recruitment of downstream DNA repair factors while sensitizing them to ionizing radiation and temozolomide. https://ift.tt/2LDYrUL

[vanalex]

Source: J. Jonker, a Type O Negative fan, from his private collection.

[vanalex]

[vanalex]

[vanalex]

And you say, we suck!!?!?

Very rare live CD from Type O Negative - live in Paradiso, Amsterdam - december 16, 1996

Source: J. Jonker

[ibaha]

‘Joker’ Looks To Break Worldwide B.O. Record For R-Rated Film, On Its Way To $900M #Joker ★Source: *https://ift.tt/2ldLEQZ ******************************************************************* In the name of Allah, the Entirely Merciful, the Especially Merciful. AL - FATIHAH 1. [All] praise is [due] to Allah, Lord of the worlds . 2. The Entirely Merciful, the Especially Merciful, 3. Sovereign of the Day of Recompense. 4. It is You we worship and You we ask for help. 5. Guide us to the straight path - 6. The path of those upon whom You have bestowed favor, not of those who have evoked [Your] anger or of those who are astray. 7. AMIN Al - Quran. ******************************************************************* Disclaimer: ========= For copyright matters please contact us at: help.100@yahoo.com ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ 💖💖💖 Sponsor And Donations...$£€₹ PayPal - help.you@aol.com Payoneer - help.you@aol.com Bitcoin - 3QF1JScZAd5qG5BCXBe8UhDZJBA2QUzp8k ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ _a joker video, a joker fan film, a joker toy, a joker music, joker blood smile, joker batman, joker baby, joker best scenes, joker bruce wayne scene, joker breakdown, joker best moments, joker box office, joker bathroom song, ever b joker, block b joker, m.o.v.i.e joker, block b joker reaction, cardi b joker, zona b joker, nicob joker, j.o.b joker, cardi b joker001, block b joker song, joker clips, joker cosplay, joker costume, joker car scene, joker canisters, joker cartoon, joker cop car scene, joker chase scene, joker comparison, joker cringe, c jonker, studio c joker, c kan joker, joker c ops, me pongo joker c-kan letra, joker c ops settings, c kan joker letra, c reel productions joker, me pongo joker c-kan instrumental, c ops joker handycam, joker dark knight, joker death scene, joker dances on stairs, joker dies, joker death, joker dancing on stairs song, joker dance song, joker drawing, d joker gezeg, d joker two face, djoker band, d rockers dance group, d jokers dance group, d.joker gezeg house mix, joker song 8d, official dj d joker, bounty hunter d joker, d&d joker build, joker edits, joker end scene, joker ending song, joker entrance, joker end credits, joker easter eggs, joker ending explained, joker elevator scene 2019, hey joker, e joker trailer, hey joker dj, hey joker dj song, hey joker 2, hey joker 2019, hey joker song dance, hey joker song 2019, hey joker dance, hey joker scene, joker final trailer reaction, joker full movie 2019, joker final scene, joker film theory, joker first trailer, joker face paint, joker film, joker final smash, f zero x joker cup, impractical jokers f, joker ta9t f adam, joker 2 face f16, f o r joker, jay f joker, joker f gamer respeita, joker gaming f, joker ember f, eufab joker f, joker gary, joker gotham, joker gary glitter, joker gaming, joker gas, joker gun scene, joker gas fortnite, joker gary glitter scene, joker gta 5, joker get what you deserve, irfu g joker, max g joker, g shock joker edition, g eazy joker, g shock custom joker, g shock joker original, g shock joker petak, joker hey song, joker hit me, joker harley quinn, joker hospital scene 2019, joker heath ledger, joker hit by car, joker halloween costume, joker highlights, joker half in the bag, joker heist, h joker dj ks, joker interview, joker impression, joker interview scene, joker irs, joker intro, joker in smash, joker ign, joker incel, joker in smash reaction, joker injustice 2, i joker movie, i joker song, i joke, i joke to you, i joke i smoke, i joke joke mo kay badman, i joke i joke i keed i keed, i joke but i don't play - tone-loc, i joke i joke sound effect, i joke i started, joker jared leto, joker joker, joker joaquin phoenix laugh, joker joe rogan, joker jimmy fallon, joker jail scene, joker joaquin phoenix scene, joker justice league, joker joaquin phoenix interview, joker jr, dj joker, dj joker song, dj joker 2019, dj joker gaan, dj joker remix, j joker beyblade, dj joker gezeg, dj joker song 2019, dj joker mix, dj joker ringtone, joker kills murray, joker kills 3 guys, joker kill count, joker kill, joker kills murray reaction, joker kills mom, joker knock knock, joker kiss scene, joker killing scenes, joker kills his friend, k joker rules, s.k joker gamer, by X World