#sound interesting? good

[awestruck-atrophy]

hello bbc sherlock fandom can I interest you in a flavor of mormor yet to be present in an actual sherlock holmes adaptation

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

--

Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[writeouswriter]

People sorting ao3 solely by stats and only clicking on fics with a certain amount of kudos or comments, you will not survive the winter, nor the summer, nor at all, *brings out knife,* run

[starry-bi-sky]

Out of Context Stuff for a Danyal Al Ghul au i haven't posted - Pit Beast Danyal

Damian, 13: Look, Danyal, -- I am so sorry for everything that happened between us in the League, I hope you can forgive me.

Danny, 10 (allegedly): (has been secretly plotting to murder Damian this whole time, is still gonna do it obvs, but is going to make it significantly less painful now)

Danny: I-- of course, older brother. :]

--------

Bruce: what do you have there, Damian?

Damian:

Danny: (a hulking 10ft pit beast standing beside him, growling idly with ram horns gouging out his eyes and a second set of horns jutting into the air, spines down his back, and a long, spiked tail with an animalistic, skull-like face)

Damian, who smuggled him in (they've made amends): a smoothie, father

----------

Damian: this is my little brother Danyal, i murdered him when he was five. He festered in rage for the last half-a decade, took over a League mountain base in Switzerland, murdered everyone inside and then tried to murder me when I went to investigate with Drake.

Danny: hello!

Damian: we're cool now

----------

Damian: thoughts on resurrection

Danny, (a full ghost): i will succeed in murdering you if you try it

Damian: we'll put a pin in it then

----------

Danny (still instilled with League values): why don't we just murder him??

Damian, on patrol (Danny followed him): we don't murder people, Danyal

Danyal:,,,,are you sick, Dami?? Have you been possessed? Why not!?

(There is raucous laughing through the comms)

----------

Danny, five, pre-death: Dami! :D

Danny, dead, vengeful: Older brother (:

Danny, post-forgiveness: Dami! :]

-------

For some actual context: Danny is fully dead in this au, its a result of the classic DPxDC Demon Twins "death duel" trope but instead of Danny getting revived, he stays fully dead. Danny was five, Damian was seven. His ghost lingered though, and due to the proximity of the pits his ghost steadily absorbed the ambient energy it was letting off. The pits are not corrupted ectoplasm in this au, it's just liquid ecto.

Which means Danny's corruption from an angry and hurt little ghost boy to an unrecognizable monster is from his own doing. It's a result of him stewing in his hurt and anger for years, it physically warped him. He's very powerful. Danny can travel between League Bases but chose a small, out-of-the-way base in the Swiss mountains to fester in and then just. Never Left.

His influence steeped into the very foundations of the building, allowing him to transform and warp the rooms and hallways for his own bidding, Meaning he could turn it into a seemingly unending labyrinth if he so wished to, and block the entrance.

Eventually, blinded (both metaphorically and physically) by his own rage, Danny grew powerful enough to appear physically in the living realm and attacked everyone in the base, slaughtering them all and leaving the base abandoned. He attacks anyone who dares enter -- whether that be other league members, or the unfortunate hiker who stumbled across the base. His conscious is steeped into every nook and cranny of the building, there is nowhere you can hide where he can't find. Nobody leaves without his explicit say so. Nobody ever does.

Him appearing as ten years old before Damian in the skits above is his own physical doing. First it was to prevent Damian from being suspicious of him. Damian initially thought Danny was revived with the pits, he was too busy with his own training afterwards to notice that Danny never showed up again, and when he did notice, he assumed it was because Danny was too ashamed of his loss to face him. He'd always forget to ask about him.

Then it becomes a personal choice to appear as ten. It's how old he would've been had he been alive.

danny forgiving Damian is kinda for an offshoot branch of the main au. Whereas the main au takes the form of a ps4 first person horror game where Damian and Tim are investigating the Base for Plot Reasons. There's no sign of the rumored "monster" living inside until the end, where Danny, who was found inside the Base and has been happily "helping" them look around, manages to persuade Damian into splitting off from Tim in order to "show him something."

This something turns out to be Danny revealing that he never really forgave Damian for that fight, and he reveals through a horrifying transformation, that he was the monster the whole time. Which the game subtly hints at throughout as Danny's strange behavior becomes harder to ignore.

First from his insistence to only refer to Damian as "older brother" (when before the duel he always called him Damian or Dami), to him right off the bat denying the existence of a monster when questioned. ("There's no monster here, older brother. It's just me.") To other various things, like his knowledge of the outside world not matching up to modern times or things going on with the league outside of the base, or what happened to the other league members.

This whole idea was inspired by the song "Scylla" from Epic the Musical, with Danyal being the voice of Scylla as well as Odysseus, while Damian stands as Eurylochus. The instrumentals after Scylla says "hello" is him turning into the pit beast, and Scylla's "drown in your sorrow and fears" part is danny, as the pit beast, snarling at Damian while he attacks him.

There's a Good Ending, a Bad Ending, and a True Ending. The Bad Ending results in Damian being killed by Danny, it happens when Damian decides not to question or suspect Danny and treats him kindly. The Bad Ending is a cutscene, where Danny kills Damian quick and painlessly.

Meanwhile the Good Ending is Damian killing Danny. This is a boss fight, and it happens when Damian treats Danny coldly and suspiciously the whole time. Danny as a result, decides to make Damian's death painful as he had planned to, which is why it's a boss fight because it only causes him to double down on his anger.

The True Ending is Damian escapes with Tim. It happens when you treat Danny warmly up until the last minute, where when Danny proposes to Damian that he wants to show him something, Damian goes to talk to Tim and finally, reluctantly agrees that something is off with Danny, and that he'll be careful going in. It starts off with the boss fight until a third through, where it then changes to a cutscene where Tim manages to get the door open and Damian escapes out. It's then a chase scene down a never-ending hallway as the building actively works to keep you trapped inside. But you eventually make it to the exit so long as you avoid all the projectiles and doors.

Remember when I mentioned that Danny only lets people leave when he wants them to? That's where the treating Danny kindly throughout the game comes into play. It causes him to second guess himself and, eventually, reawaken and strengthen the love and admiration he had for Damian prior to his murder. It's why in the Bad Ending he kills Damian quickly -- because by then, he loves him enough that he doesn't want him to suffer, but is still so consumed by his rage and need for vengeance that he kills him anyways. That quiet part is what allows Damian (and Tim) to find the exit, because some part of Danny still loves Damian enough that he wants him to live.

The True Ending ends with a cutscene of Damian and Tim tumbling out into the snow/grass outside of the base. Damian looks up back to the entrance to see Danny standing there. But rather than a ten year old boy, there's a little five year old Danyal Al Ghul instead. He stares at Damian emotionlessly, blood seeping from his chest, staining his clothes, and little, bloody sword in his hands and tearstains on his cheeks, before he turns away and disappears back into the building.

[felsicveins]

I'm so lonesome all the time

Some sweet day

Gonna take away

This hurting inside

[qwantzfeed]

ceci n'est pas une pipe?  more like ceci n'est pas une intellectual property crime in just a few months and honestly, i hate to wait

[poorly-drawn-mdzs]

hope you feel better soon!

I am riddled with ailments, but I stay silly!

[babacontainsmultitudes]

Not a Francis hater, not a Francis apologist, but a secret third thing (watching him be a fucked up little freak and enjoying the show 🍿)

[infinitelystrangemachinex]

massages forehead So Ambessa hid Mel away because she was a weapon in the literal sense, a mage. But Ambessa came to Piltover for Hextech? And Ambessa had nothing to say to Mel about her powers having visibly awakened? Even when Mel offered to go with Ambessa, giving her the ultimate opportunity to make Mel a weapon for real? And Ambessa made no attempt to find or retrieve Mel - not just her daughter and the remnants of the family Ambessa professes to love, but also her ultimate weapon - when she disappeared? And Ambessa trusted Singed and Viktor on their home turf - neither of them hiding how insane and self-serving they are with every reason to take over Ambessa's soldiers or just blatantly turn on her as soon as it benefits them - more than she trusted Mel? While Caitlyn (and by extension Piltover) was visibly and clearly falling away from Ambessa's teachings before Ambessa's eyes? (as if getting rid of certain people allows piltover to get rid of fascism but we won't get into All That)

Not only do I struggle to be hyped for Mel's powers beyond how amazing and beautiful she looks, but I can't help but feel like Mel is somehow less powerful in season 2 than she was in season 1, and not in an interesting way. As if Mel's ability to bend all of Piltover politics and economics to her will in season 1 now means nothing in season 2? You can argue that Jinx's attack led directly to Mel losing ground in Piltover - because I expected Mel to have to claw back that power without being able to rely on people who are too easily seduced by Ambessa and authoritarianism, and she would have to get creative to go toe to toe with her mother. I expected pushback to her mage identity that she would have to navigate. But instead this went either unwritten, or was ignored or discarded. Instead Mel is removed from the main plot, cutting her off from what made her the most interesting - only for all of Mel's very real talents, her very real powers and abilities, to be not only translated but REPLACED with magical powers she doesn't know how to control, and by the finale, those magic powers are the only powers that are considered real. Mel takes a backseat to Piltover's governing and decisions, a backseat to Jayce of all people who was not only new to politics mere months ago but made poor governing, strategic, and diplomatic decisions when he had that power. In season 1 Mel stayed off the "throne" but she did pull its strings one way or the other, and she makes no attempt at this in season 2

In my least generous suspicions, Mel was gentled and quieted to capitulate to an agenda for other characters who had to be correct and heroic - or wrong and villainous - no matter what the leadup narrative said, given her powers to help sell the game and set up future shows, and was effectively ejected from the Arcane story with faceless soldiers and a role she doesn't want because she was inconvenient there

[ohno-the-sun]

Vibrating with happiness I got them signed aaaaa

[justjensenanddean]

‘Tracker’: Justin Hartley on Working With Good Friend Jensen Ackles for First Time

ET has a first look at Justin Hartley and Jensen Ackles on set of ‘Tracker’ season 2, which airs Wednesdays on CBS.

[s0fter-sin]

god the way ghost’s voice drops when he tells soap, “you’ll need to improvise to survive”

before that, everything he says is steady but when he acknowledges that soap’ll have to do something outside his skill set, something he intimately knows to be difficult, his voice wavers. he does the same when he says, “welcome to guerrilla warfare”; it’s sombre and serious in a way he doesn’t act for the rest of the mission. if you read into it enough, he almost sounds apologetic; like he knows exactly what soap’s about to go through and wishes he didn’t have to

he keeps soap going; poking at him and making jokes, giving him tips and asking about his progress. he never lets him stop and take a second to think bc he knows the moment he does is the moment it'll all hit him; the betrayal, the pain, the fear, the deaths, all of it will drown him and if that happens, soap won't make it

he needs him to be a soldier through and through and he knows this is one of the worst kinds of battlefields you could end up on

and the only times he slips is when he acknowledges that fact

it happens again when he says, "tryin' to get you here alive and in one piece". his jovial dark humour facade drops for just a moment when he has to face the potential reality of losing soap. then he tries to pick it back up again with, "one of us has to survive to tell the tale"; completely discounting himself as a survivor to try and rally soap and make him think it’s all down to him

and soap does the same thing

when he's calling out for ghost on the radio, he's tentative, testing the frequency, then when he doesn’t get a response, he grows desperate; "ghost, this is 7-1, do you copy?"

then when ghost answers, he smooths out his voice; he hides the pain, the fear, and no matter what response you give to ghost asking if he’s injured, soap brushes it off (“i’m good”, “what’s the difference?”, “i’m not a medic”). soap decides it’s in ghost’s best interest to hide the extent of his injuries

he doesn’t know where ghost is, if he’s secure, if he has any weapons; he doesn’t even know if he’s in las almas until he says, “there’s a church, i’m headed to it”. for all he knows, he could’ve run in the complete opposite direction. if ghost knows he’s hurt, then his attention would be split between his own survival and soap’s

and soap, who lets himself be poked and prodded towards the church, needs to hide his own doubts. maybe he needs ghost to believe he'll make it so he himself can believe it ("what are my odds?" "don't make me bet against you", "think i'll live that long?" "probably not")

he all but begs ghost to tell him he'll get through it and if he knows just how bad off he is, maybe he'll change his mind. maybe he'll think he won't make it to the church

maybe he'll leave him alone for good

"you injured?"

"i’m good"

"let's find out how good you are"

[ryllen]

something i promised on my kofi 6 months ago... 🫠

[dittydipity]

played the researcher and seeker event. this is what they are to me

[turtleblogatlast]

One of the biggest things that makes me see Leo as trans is absolutely the size of his carapace in comparison to his brothers’.

And I’m not talking about height! I’m specifically looking at his shell here, because when you compare him to the others, particularly Donnie who is nearly the same height as Leo, it’s very clear that Leo’s carapace is much longer in proportion to the rest of his body.

Like - standing side by side, even though Donnie is shorter his carapace ends noticeably higher up than Leo’s does. And I like this not only because it really helps push the idea that Leo could very likely be trans (or intersex!), but it’s also just a fun design difference between them.

(It also lends way to future scenarios of Donnie eventually getting taller than Leo, but sitting down still has Leo being the taller one haha.)

[sysig]

“It could be that the loss of her children drove the Queen deeper into her darker desires...but, I don’t believe she was fighting against them that hard before that particular tragedy. No monster does.” (Patreon)

Bonus:

Hmm, wonder what he could cover those holes with :3c