#senolytic activator

[jim-fetter-illustrations]

We Humans aren't designed to live forever, but we can live longer than we do!

Most “anti-aging” supplements that many popular websites and books recommend do NOT slow down your aging process, they mostly benefit your health as you get older, and you are still ageing at the same rate you always have.

These are substances like vitamin A, vitamin E, coenzyme Q10, lipoic acid, B-vitamins, calcium, omega-3 fatty acids, zinc, multivitamins, curcumin, EGCG, nicotinamide riboside (NR), mushroom extracts and many more are great supplements but they won't slow down your aging!

This means many touted “anti-aging” supplements are nothing more than antioxidants, which do improve your health as you age, like vitamin A, vitamin E, coenzyme Q10, lipoic acid and so on. But they don’t slow down aging. Some antioxidants can even accelerate aging, like lipoic acid or vitamin A and vitamin E.

Ya see,... We human beings aren't supposed to live forever so we have an aging process which triggers (kicks in) at a certain age, and it's downhill from there on. We have a built in fail point, just like automobiles do, so they can keep selling us cars forever.

Ya wanna know what does slow down your ageing process, and they SLOW DOWN not stop it..........

1. "Fisetin", a natural ingredient found in vegetables and fruits, especially in strawberries. Fisetin is mostly known for its senolytic activity, meaning it can clear away senescent cells, ..... zombie cells literally that have done their job biologically but reuse to die off, and are still hanging around sponging off of other healthy cells, like many of our political leaders do.

2. Alpha-ketoglutarate (the calcium form)

Alpha-ketoglutarate (AKG) is a substance that naturally occurs in our bodies. When we get older, the levels of AKG decline. Most studies show in mice that they live 14% longer than mice that didn't take Alpha-ketoglutarate (AKG).

3. Microdosed lithium

Lithium is a mineral found in nature. It seeps from rocks into water, including drinking water, like natural spring water.

Various studies show the more amount of lithium in the drinking water the longer people have been living in that area, and had less neurodegenerative diseases like Alzheimer’s.

So the further you are from the city the better off health wise you are.

Can you see the stars at night,...... if not your still to close to the city!

4. Glycine

Glycine is an amino acid that occurs naturally in our body. When we age, glycine levels decline.

Glycine has many functions in the body. It improves the epigenome (the machinery that determines which genes are switched on or off, a process that goes increasingly awry when we get older). Glycine especially improves the epigenome of mitochondria, the power plants of our cells.

5. Pterostilbene

Pterostilbene is the better brother of the famous anti-aging substance resveratrol.

Resveratrol has long been hyped as a longevity substance. However, it unfortunately did not live up to that hype. Studies showed disappointing results when it came to resveratrol extending lifespan.

6. Malate or malic acid

Malate, also called malic acid, is found in apples, and in our own bodies.

Malate is an important substance in the mitochondria. In fact, malate is a component of the Krebs cycle, which consists of various substances that are chemically modified to provide the energy that keeps all cells going.

7. Magnesium

Magnesium is an indispensable mineral for the body to function properly.

Magnesium helps innumerable enzymes in our body to function properly. Cells shuttle magnesium in and out to propagate nerve signals and to generate muscle impulses, including the beatings of our heart.

Magnesium also sticks to our DNA, stabilizing our DNA, protecting it against damage. Increasing DNA damage is one of the reasons why we get older.

8. Glucosamine (the sulfate form)

Most people know glucosamine as a substance to reduce wear and tear of cartilage and to improve joint health.

Few people know that glucosamine can also extend lifespan in different organisms, including mice.

Studies show that glucosamine is one of the few supplements associated with reduced mortality in humans, and also reduced risk of cardiovascular disease in humans.

9. Hyaluronic acid

Hyaluronic acid is an important component of the skin. But hyaluronic acid (HA) surrounds and embeds many other cells in the body than just the skin cells.

The older we get, the less hyaluronic acid there is in the body. A 70-year-old has only about 19 percent of the amount of hyaluronic acid of a young person.

Studies show that hyaluronic acid, taken orally, can improve skin appearance by reducing wrinkles, improving moisturization of the skin and increasing skin radiance. It can also improve osteoarthritis, which makes sense given joints and cartilage contain a lot of hyaluronic acid.

10. Ginger

Ginger is a well-known spice. But it’s not just any spice, it's THE SPICE for longevity.

Many scientific studies demonstrated multiple beneficial health effects of ginger, like reducing inflammation and protecting cells against damage.

Ginger has been found to extend lifespan in simple organisms, like fruit flies.

Ginger can improve type 2 diabetes and inflammation in humans.

11. Rhodiola rosea

Rhodiola rosea is a very interesting plant that grows in the northern regions of Europa and Asia.

Rhodiola rosea has been used for centuries as an adaptogen, a substance that can improve resilience against both physiological stress and mental stress.

Rhodiola can also improve nerve regeneration.

Studies in humans show that Rhodiola rosea can improve memory, concentration and can reduce fatigue.

12. L-theanine

Theanine is a substance found in green tea, and is one of the reasons why green tea is healthy.

Theanine has been shown to extend lifespan in simple organisms.

Theanine has been associated with healthier blood vessels, and could reduce blood pressure and even obesity.

Theanine has shown to reduce neurodegeneration and protect neurons in the body.

13. Nicotinamide mononucleotide (NMN)

Nicotinamide mononucleotide (NMN) is needed to make NAD+.

NAD+ is a very important substance in the cells. It provides energy for cells and is also a cofactor for proteins that repair and maintain our epigenome and our DNA.

NMN improves metabolism and reduces inflammation.

In conclusion I can say I've studied anti-aging for decades and many anti-aging supplements are based on outdated insights and don’t have any or just very little science backing up their claims.

Also, they do not contain substances that have been shown to act on aging mechanisms.

I personally have been taking 5 of these 13 supplements for a decade, so I should outlive your grandchildren, Lol

I would say if you just took one of these 13 it should be L-Glycine, because Glycine is like the switch that turns on the light in the room, and if the switch doesn't work nothing else gets what it need to illuminate you.

Ginger being a close second to take, which both are fairly cheap in cost to get pharmaceutical grade supplements, and remember only pharmaceutical grade supplements are worth a damn, because Choosing a pharmaceutical-grade supplement is the only way to know for sure that you're giving your body the highest, purest, and most bioavailable form of an ingredient possible, so if it doesn't say "pharmaceutical-grade" on the label, it isn't!!

As Spock from Star Trek would say "Live Long And Prosper", and you do that by knowing how!

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[anujmrfr]

The Age of Healthy Aging: Trends in the Longevity Industry

Redefining Aging: The Dawn of the Longevity Economy

The Longevity Market is a rapidly emerging and transformative sector focused on extending human healthspan—the period of life spent in good health—rather than merely increasing lifespan. This interdisciplinary market encompasses a vast array of products, services, and technologies aimed at preventing, delaying, or reversing age-related diseases and decline. It spans diverse fields, including biotechnology, pharmaceuticals, regenerative medicine, personalized nutrition, preventive healthcare, digital health, age-tech (technology for older adults), and even financial services tailored for extended lives. Driven by an aging global population, scientific breakthroughs in aging biology, and a growing consumer desire for a healthier, more active later life, the longevity market is poised for exponential growth. As of mid-2025, the market is experiencing significant investment and innovation, with projections indicating a global value exceeding USD 63 billion by 2035, growing at a compound annual growth rate of over 10%.

Key Market Drivers and Scientific Frontiers

Several powerful factors are propelling the longevity market forward. The most significant driver is the rapidly aging global population. As the number of individuals aged 60 and above is expected to double by 2050 to surpass 2 billion, there is an immense and growing demand for solutions that enable people to live healthier, more productive lives for longer. This demographic shift is creating vast market opportunities across various sectors, from healthcare to consumer goods and financial services. Furthermore, groundbreaking scientific advancements in aging biology are revolutionizing our understanding of the aging process. Researchers are identifying and targeting the molecular and cellular hallmarks of aging, paving the way for truly transformative interventions.

Scientific and technological innovation is at the core of this market's expansion. Key areas of focus include regenerative medicine, with advancements in stem cell therapy and tissue engineering showing promise in repairing damaged tissues and rejuvenating organs. Senolytics and cellular therapies are emerging as a major frontier, targeting and eliminating senescent (aging) cells that contribute to age-related inflammation and dysfunction. Technologies like CRISPR gene editing offer the potential to correct genetic predispositions to age-related diseases. The increasing adoption of biomarker analysis and preventive genomics is enabling personalized longevity interventions, allowing individuals to understand their biological age and tailor their lifestyle and medical strategies. Artificial intelligence (AI) and machine learning (ML) are playing a pivotal role in accelerating drug discovery, identifying novel therapeutic targets, and personalizing health recommendations based on vast datasets of genetic, metabolic, and lifestyle information. The rise of the "biohacking" and "wellness" movements further fuels consumer demand, with individuals actively seeking dietary supplements, exercise regimens, and digital tools to optimize their health and extend their healthspan. Wearable devices and smart health apps are increasingly becoming integrated components of longevity strategies, providing real-time data on health metrics.

Market Segmentation and Investment Landscape

The longevity market is incredibly diverse and can be segmented by various solutions and services: therapeutic interventions (e.g., senolytics, regenerative medicine, gene therapies), diagnostics (e.g., biological age testing, genetic testing), digital health and wellness platforms (e.g., health tracking apps, personalized nutrition advice), financial services (e.g., retirement planning for extended lifespans, long-term care insurance), and age-friendly products and services (e.g., smart home technologies, accessible travel).

Geographically, North America, particularly the US, dominates the longevity market due to its robust venture capital ecosystem, cutting-edge research institutions, and a large consumer base focused on health optimization. Europe, with countries like the UK, Germany, and Switzerland, is also fostering a growing number of longevity startups and research centers. The Asia-Pacific region, especially Japan, South Korea, and Singapore, is investing heavily in longevity R&D, driven by some of the world's oldest populations. Challenges for the market include the significant R&D costs, the complex regulatory pathways for novel anti-aging therapies, and ethical considerations surrounding life extension. Despite these challenges, the unprecedented confluence of demographic trends, scientific breakthroughs, and burgeoning investment ensures that the longevity market will continue its rapid expansion, fundamentally reshaping healthcare, economies, and how humanity perceives and experiences aging.

About Market Research Future (MRFR) Market Research Future (MRFR) is a global market research firm that provides comprehensive insights into market trends, drivers, challenges, and opportunities. We offer a broad range of market intelligence reports and consulting services to help businesses and enterprises in various industries make informed decisions

Media Contact: Market Research Future (MRFR) Phone: +1-646-845-9312 Email: contact@marketresearchfuture.com Website: marketresearchfuture

[levitasacademy]

Longevity: The Art and Science of Living Longer, Healthier 

Longevity is more than just living a long life—it’s about living well for as long as possible. The pursuit of longevity has captured human interest for centuries, but only in recent decades has science begun to unlock the secrets to a longer, healthier lifespan. With the right habits, many of us can add not just years to life, but life to those years 

What Is Longevity? 

Longevity refers to a long duration of life, but in the health and wellness world, it increasingly means “healthspan”—the number of years we live free from chronic illness or significant decline. Living to 90 or even 100 is not uncommon today, but the goal is to arrive at those ages in good physical and mental condition. 

Several factors influence longevity, including genetics, environment, healthcare access, and most importantly, lifestyle choices. 

Key Lifestyle Habits That Promote Longevity 

Nutrition  Diet is one of the most powerful tools for longevity. Blue Zones—regions where people live significantly longer—typically follow plant-based, whole-food diets. Key principles include: 

Eating plenty of vegetables, legumes, and whole grains 

Limiting processed foods and sugar 

Using healthy fats like olive oil 

Eating smaller portions and avoiding overeating 

Movement and Physical Activity  Regular exercise is linked to a lower risk of nearly every age-related disease. Activities like walking, strength training, stretching, and balance exercises can keep the body functional well into old age. Even moderate activity, like gardening or taking the stairs, contributes to improved lifespan. 

Sleep and Recovery  Sleep is a non-negotiable component of long-term health. Adults who consistently get 7–9 hours of quality sleep show better immune function, hormone regulation, and brain health—all vital for longevity. 

Mental and Emotional Wellbeing  Chronic stress, depression, and social isolation can negatively impact healthspan. Practices like meditation, gratitude, therapy, and strong social connections support brain health and reduce inflammation. 

Purpose and Community  Having a sense of purpose—whether through work, volunteering, family, or creative pursuits—has been shown to increase life expectancy. Likewise, social ties play a significant role. Loneliness is now considered a major risk factor for early mortality. 

Interesting Facts About Longevity 

The world’s oldest verified person, Jeanne Calment, lived to 122 years. 

In Okinawa, Japan, many centenarians credit their longevity to “ikigai,” meaning a sense of purpose. 

Genetics account for only 20–30% of longevity, while lifestyle factors influence the majority. 

Blue Zones like Sardinia (Italy), Nicoya (Costa Rica), and Ikaria (Greece) show that culture and community are just as important as food and exercise. 

Modern Advances in Longevity Science 

Science is also playing a key role in the longevity revolution. Researchers are studying the biology of ageing, including telomere shortening, oxidative stress, and cellular senescence. Interventions like intermittent fasting, NAD+ boosters, and senolytics are being explored for their potential to slow down the ageing process. 

In parallel, wearable health tech, DNA testing, and personalised medicine are enabling people to track, understand, and respond to their own health data in real time. 

Conclusion 

Living longer is no longer a far-fetched dream—it’s a realistic goal for many, provided they make intentional choices. Longevity isn’t about chasing eternal youth, but about maintaining vitality, independence, and joy for as long as possible. Whether through diet, movement, mindset, or community, the path to a long and fulfilling life is well within reach. 

For those in the medical or wellness fields, exploring longevity-focused education can be a powerful step. Specialised longevity medical courses now offer professionals the tools to support healthy ageing in their clients—combining science, preventative strategies, and personalised care to extend both lifespan and healthspan. 

[rakesprogress212]

The Future of Aging: Longevity Science Breakthroughs

The traditional view of aging as inevitable decline is being overturned. Research from the Buck Institute reveals that only 30% of aging is genetically predetermined - the remaining 70% stems from modifiable factors. This understanding has spawned a new field of longevity science aiming not just to extend life but to compress morbidity, preserving vitality into advanced age.

Cellular Repair Mechanisms At the forefront are senolytic therapies that target "zombie cells" accumulating with age. Early clinical trials show these compounds can reverse aspects of aging in human tissue. NAD+ boosters, which enhance cellular energy production, demonstrate promise in restoring muscle and cognitive function. Perhaps most remarkably, partial cellular reprogramming experiments have successfully reset aging markers in animal models.

Nutritional research has identified specific protocols with measurable anti-aging effects. Time-restricted eating aligns with circadian biology to enhance cellular cleanup processes, while certain polyphenols activate longevity pathways. The VALID study found participants following a "longevity diet" showed biological markers 3 years younger than chronological age.

The Longevity Lifestyle Beyond laboratory interventions, behavioral factors prove equally powerful. The Blue Zones studies identified common habits among populations with exceptional longevity: natural movement throughout the day, strong social connections, purposeful living, and plant-rich diets. Modern adaptations include "exercise snacks" - brief activity bursts that maintain metabolic flexibility - and cognitive challenges that build neuroplasticity.

Ethical considerations accompany these advances. Access to longevity interventions risks creating health disparities, while lifespan extension raises questions about retirement structures and intergenerational equity. Researchers emphasize that the goal isn't immortality but "healthspan" - preserving quality of life throughout our years.

[edgythoughts]

Why Do Cells Age and Die 2025

Why Do Cells Age and Die 2025

Cells—the basic units of life—do not live forever. Like all living things, they have a natural life cycle: they grow, perform functions, divide, and eventually die. But why does this happen? Why can’t a cell just keep going endlessly? In 2025, thanks to major breakthroughs in cell biology, genetics, and aging science, we now have a clearer understanding of the cellular aging and death process than ever before. Let’s explore what makes cells age, why they eventually die, and how this ties into larger systems like aging, disease, and life expectancy. Book-Level Explanation Cells age and die due to both internal mechanisms and external factors. There are two main biological processes that drive this: 1. Cellular Senescence Cellular senescence refers to a permanent state where cells stop dividing but remain metabolically active. It’s usually triggered by DNA damage, oxidative stress, or the shortening of telomeres (protective ends of chromosomes). Senescent cells don’t die immediately, but they lose their ability to function normally and may release inflammatory signals that can harm neighboring cells. 2. Programmed Cell Death (Apoptosis) Apoptosis is a highly regulated and natural form of cell death. It plays a vital role in development, immune response, and tissue homeostasis. When a cell is damaged beyond repair, or if it’s no longer needed (such as after an infection is cleared), it undergoes apoptosis to safely dismantle and remove itself. Other factors also play key roles: - Telomere shortening: Telomeres act like protective caps at the end of chromosomes. With every division, they get shorter. When they become too short, the cell can no longer divide. - DNA damage: Radiation, toxins, and errors in replication can damage DNA. If the damage is too extensive, it can trigger senescence or apoptosis. - Mitochondrial dysfunction: As cells age, mitochondria (energy-producing organelles) become less efficient and produce more reactive oxygen species (ROS), which damage cellular components. These mechanisms are essential for the survival of organisms. They prevent the spread of damaged or potentially cancerous cells and help renew tissues. Easy Explanation Think of a cell like a little worker in your body. It has a job to do—maybe it builds things, cleans waste, or helps protect you from germs. But even the hardest worker gets tired over time. That’s basically what happens with cells. Every time a cell divides, it makes a copy of itself. But with each copy, its "shoelace tips" (called telomeres) get shorter. When those tips are too worn out, the cell can’t divide anymore. It’s like trying to tie your shoes with frayed laces—it just doesn’t work. Some cells also get sick from stress, like too much sun, pollution, or chemicals. When they’re damaged beyond repair, they self-destruct through a process called apoptosis. This is the body’s way of recycling broken or dangerous cells so new, healthy ones can take their place. Sometimes, a cell doesn’t die right away but goes into “retirement” mode. It’s still alive but not really working anymore. These retired cells are called senescent cells. If too many build up, they can actually cause inflammation and problems in your body. So, cells age and die to keep your body clean, efficient, and healthy. If they didn’t, damaged cells could cause serious issues like cancer.

Why This Matters in 2025 In the last few years, scientists have made major progress in understanding and even reversing some parts of the aging process. Some highlights: - Researchers have identified compounds called senolytics that can selectively remove senescent cells from tissues. Early trials show these might help reduce age-related inflammation and improve health span. - CRISPR and other gene-editing tools are being used to investigate telomere extension and DNA repair. - Studies in model organisms have shown that controlling mitochondrial health can slow down cellular aging. There’s even speculation that cellular rejuvenation techniques could one day delay aging and age-related diseases in humans. Real-World Impact The way cells age and die affects everything from your skin wrinkling to the development of Alzheimer’s, cancer, and heart disease. It also plays a role in immune system decline, making older adults more vulnerable to infections. By better understanding this process, researchers can: - Develop anti-aging therapies - Create more effective cancer treatments - Improve regenerative medicine (e.g., using stem cells) - Enhance organ transplant outcomes This field is central to the future of personalized and preventative medicine.

Conclusion

Cells age and die because it’s part of nature’s way of maintaining balance. While it might seem like a flaw, it’s actually a protective system that helps your body stay healthy. In 2025, scientists are closer than ever to unraveling the secrets of cellular aging—and perhaps even learning how to slow it down. External Link for Further Reading: Learn more about cell aging and programmed death on Wikipedia: https://en.wikipedia.org/wiki/Cell_senescence Our Blogs You Might Like What If Human Consciousness Could Be Uploaded Into Light 2025 https://edgythoughts.com/what-if-human-consciousness-could-be-uploaded-into-light-2025 How Do Gut Bacteria Shape the Brain 2025 https://edgythoughts.com/how-do-gut-bacteria-shape-the-brain-2025 Disclaimer: The easy explanation is designed to help readers of all backgrounds understand complex scientific concepts. If you're a student, always follow your school's guidelines and refer to your textbooks or academic materials when preparing for exams or assignments. We're here to support your learning—not replace your curriculum. Read the full article

[didanawisgi]

https://onlinelibrary.wiley.com/doi/10.1111/acel.70053?fbclid=IwZXh0bgNhZW0CMTEAAR7plAx6qlUxReL2a7drkjav_SEozywwWTEzfG3ouJ3HscLjHMCZ1iBGu3grcw_aem_fAkm8NrxjSCd5gtITeq-RA

Targeting IGF1-Induced Cellular Senescence to Rejuvenate Hair Follicle Aging

ABSTRACT

The insulin-like growth factor-1 (IGF-1) signaling pathway is known as a potent aging modifier, disruption of which consistently associates with lifespan extension across diverse species. Despite this established association, the mechanisms by which IGF-1 signaling modulates organ aging remain poorly understood. In this study, we assessed age-related changes in IGF-1 expression across multiple organs in mice and identified a more prominent increase in skin IGF-1 levels with aging—a phenomenon also observed in human skin. To explore the consequences of elevated IGF-1, we developed transgenic mice ectopically expressing human IGF-1 in the epidermis, driven by the bovine keratin 5 promoter (IGF-1 Tg). These mice exhibited premature aging of hair follicles, as evidenced by accelerated hair graying and loss. Single-cell RNA sequencing analyses of dorsal skin highlighted an upsurge in cellular senescence markers and the senescence-associated secretory phenotype (SASP) in hair follicle stem cells (HFSCs), alongside a decline in hair growth and HFSC exhaustion. Our findings indicate that excessive IGF-1 triggers HFSC senescence, thereby disrupting hair follicle homeostasis. Remarkably, interventions in IGF-1 signaling via downstream mechanisms—specifically blocking Ac-p53 activation via SIRT1 overexpression or senolytic treatment for senescent cell clearance, or reducing IGF-1 through dietary restriction—significantly reduced senescence markers, mitigated premature hair follicle aging phenotypes, and restored the stem cell pool. Our findings provide fundamental insights into the biological processes of hair aging and highlight the therapeutic promise of targeted interventions to rejuvenate aged HFSCs and promote hair follicle health.

[everwelllab]

Why This Study on Hair Aging Changed How I Think About Hair Loss

I’ve always wondered why some people keep thick, dark hair while others start graying and thinning early. Genetics play a role, sure—but this study suggests hormones and cellular aging are just as important.

The Problem: When IGF-1 Speeds Up Hair Loss

IGF-1 is a hormone we usually associate with youth and repair. But researchers found that as mice aged, their skin produced more IGF-1, and humans showed the same pattern. So they took it further—genetically modifying mice to overproduce IGF-1 in their skin. The result?

Hair turned gray and fell out faster

Hair follicle stem cells (HFSCs) burned out

Inflammation and cellular exhaustion set in

Basically, too much IGF-1 made stem cells work overtime until they couldn’t function anymore. Instead of preserving hair, it sped up aging.

How They Tried to Fix It

Once they saw the damage, researchers tested ways to slow or reverse it:

Blocking p53 activation via SIRT1 – Prevented stem cell burnout

Senolytics (removing aging cells) – Cleared out exhausted stem cells

Dietary restriction (naturally lowering IGF-1) – Helped preserve hair follicle function

All three helped restore some stem cell activity and slow hair loss.

Limitations & What’s Still Unclear

It’s a mouse study – Human biology is more complex.

IGF-1 balance is tricky – Too much ages follicles, too little weakens muscles and bones.

Other factors matter – Stress, inflammation, and diet also impact hair health.

What This Means for Me (and Maybe You)

Reading this made me rethink my own habits. Could my diet and lifestyle be pushing IGF-1 higher and accelerating hair aging? Here’s what science suggests might help:

Intermittent fasting & caloric restriction – Lowers IGF-1 naturally.

Moderate protein intake – Animal protein (especially dairy) spikes IGF-1.

Exercise (but not overtraining) – Strength training helps, but excessive workouts can backfire.

Less sugar & processed food – High insulin drives IGF-1 up.

Better stress management & sleep – Chronic stress disrupts IGF-1 regulation.

The Big Question: Can We Slow Hair Aging Naturally?

I used to think hair loss was mostly about genetics, but now I’m convinced hormones and lifestyle matter just as much. If small changes can keep hair follicles working longer, why not try them?

Would you change your habits if it meant keeping your hair healthier for longer?

[biopractify]

Reverse Aging with Biotechnology

1. What Causes Aging? The Science Behind Getting Older

Aging isn’t just about wrinkles and gray hair—it’s a biological process driven by genetic, molecular, and environmental factors. Scientists have identified key mechanisms that contribute to aging, including:

🧬 Telomere Shortening – Telomeres (protective caps on chromosomes) shorten with each cell division, leading to cellular aging and death. 💥 Cellular Senescence – Old or damaged cells stop dividing but remain in the body, causing inflammation and disease. 🔬 Mitochondrial Dysfunction – Energy-producing mitochondria become less efficient, accelerating tissue and organ decline. ⚖ Epigenetic Changes – Environmental factors modify gene expression, turning "aging genes" on or off. 🦠 Loss of Stem Cells – The body's ability to repair itself decreases as stem cell production declines.

If we can target these processes, we may be able to slow, halt, or even reverse aging.

2. The Most Promising Anti-Aging Biotechnologies

Scientists are exploring several cutting-edge technologies that could help us fight aging at the molecular level. Here are the most promising breakthroughs:

🧬 Gene Therapy: Editing the Code of Life

Gene editing tools like CRISPR allow scientists to modify DNA, potentially reversing age-related damage. ✅ Example: In 2020, a biotech company successfully extended the lifespan of mice by 25% using gene therapy. 🔬 Researchers are investigating telomerase activation, which could extend telomeres and prevent cellular aging.

🦠 Stem Cell Therapy: Regenerating the Body

Stem cells have the ability to repair damaged tissues and regenerate organs. ✅ Example: Studies show that stem cell injections can rejuvenate aged tissues and improve cognitive function. 🔬 Companies like Altos Labs are investing billions into stem cell-based age-reversal therapies.

💊 Senolytics: Clearing Out Aged Cells

Senolytic drugs target and remove senescent cells—those "zombie cells" that contribute to aging and inflammation. ✅ Example: In clinical trials, senolytics improved lung function, heart health, and lifespan in mice. 🔬 Human trials are underway to test their effectiveness in reversing age-related diseases.

🧪 NAD+ & Metabolism Boosters

NAD+ (Nicotinamide Adenine Dinucleotide) is a vital molecule that declines with age. ✅ Example: NAD+ supplements have shown promise in restoring cellular energy and slowing aging. 🔬 Companies like Elysium Health are developing NAD+ boosters to promote longevity.

🖥 AI & Drug Discovery

AI is revolutionizing anti-aging research by analyzing massive datasets to identify new longevity drugs. ✅ Example: AI-driven drug discovery has led to the development of rapamycin derivatives, which may extend lifespan. 🔬 AI helps identify genetic markers of aging, accelerating the search for anti-aging therapies.

3. Can We Reverse Aging in Humans? The Latest Research

While many anti-aging treatments have worked in animals, human applications are still in early stages. Here are some groundbreaking studies:

📌 Harvard Researchers Reversed Aging in Mice – Scientists used a combination of gene therapy and Yamanaka factors to rejuvenate aged mice. 📌 Epigenetic Reprogramming Shows Promise – Partial reprogramming of cells has been shown to restore youthful function in aged tissues. 📌 First Human Trials Underway – Several biotech companies are testing gene therapies and longevity drugs in humans.

Although we’re not yet at the stage of full human age reversal, these advances are bringing us closer than ever.

4. The Challenges & Ethical Questions

Reversing aging isn’t just a scientific challenge—it also raises ethical, social, and economic concerns:

🛑 Safety Risks – Many anti-aging treatments involve genetic modification, which carries unknown long-term effects. ⚖ Who Gets Access? – If anti-aging treatments become available, will they be affordable for everyone or just the wealthy? 🌍 Overpopulation – If people live significantly longer, how will this impact the planet’s resources? 🤖 Playing God? – Should humans be interfering with the natural aging process?

These ethical dilemmas will need to be addressed as anti-aging technology advances.

5. The Future of Longevity: How Close Are We?

🚀 By 2030: Expect more anti-aging drugs and early-stage gene therapies. 🚀 By 2050: Potential for widespread cellular rejuvenation treatments. 🚀 By 2100: Could we see human lifespans of 150+ years? Some scientists believe it's possible.

With biotech giants, AI-driven research, and government funding, we are moving closer to an age where aging itself becomes optional.

Final Thoughts: The Future of Aging is Here

While full age reversal isn’t possible yet, biotechnology is unlocking ways to slow and even partially reverse aging. Gene therapy, stem cells, senolytics, and AI are leading the way toward longer, healthier lives.

🌟 The big question: If aging becomes reversible, would you want to live forever? Share your thoughts below

[pandey879676]

Beyond the Fountain of Youth: Exploring Modern Anti-Ageing Solutions

The quest for eternal youth has long captivated the human imagination. From ancient myths of the Fountain of Youth to modern-day breakthroughs in medical science, the desire to age gracefully and live longer remains universal. In today's world, the conversation around anti-ageing is evolving from mythical pursuits to scientifically-backed strategies aimed at not only extending life but improving its quality. But what does the future of anti-ageing look like, and how can modern solutions help us defy the natural process of aging?

The Science of Ageing: A Brief Overview

Ageing is a complex biological process that affects every cell in the body. At the cellular level, it involves a combination of genetic and environmental factors that lead to the gradual decline in the function of tissues and organs. DNA damage, oxidative stress, inflammation, and the shortening of telomeres (the protective caps on our chromosomes) are some of the key contributors to ageing.

While we can't stop time, scientific advancements have brought us closer to understanding these mechanisms, allowing us to develop methods to slow them down or reverse their effects. From genetics to lifestyle changes, researchers are exploring various anti-ageing solutions that target the root causes of aging.

Cutting-Edge Anti-Ageing Therapies

In recent years, the development of anti-ageing treatments has gained significant momentum. Here are some of the most promising modern solutions:

Gene Therapy and CRISPR Technology Gene therapy is rapidly advancing, with scientists looking for ways to repair or replace damaged genes that cause age-related diseases. CRISPR, a revolutionary gene-editing tool, is being investigated for its potential to extend lifespan by targeting the genes responsible for ageing. Researchers are hopeful that these technologies could one day allow us to slow down or even reverse the effects of ageing at a genetic level.

Senolytics: Eliminating Senescent Cells One of the key breakthroughs in anti-ageing research is the discovery of senescent cells – cells that no longer divide or function properly, contributing to age-related inflammation and tissue dysfunction. Senolytics are compounds designed to target and eliminate these dysfunctional cells, potentially reducing the effects of ageing and enhancing overall health.

Telomere Extension Telomeres are protective structures at the ends of chromosomes that shorten with age. The shorter the telomeres, the more likely we are to experience age-related diseases. Scientists are studying ways to lengthen telomeres using enzymes like telomerase to slow down the ageing process. While still in the early stages, these therapies could hold promise for extending human lifespan.

Nutraceuticals and Anti-Ageing Supplements The role of nutrition in ageing is well-documented, and many scientists are focusing on developing supplements that may help slow the aging process. Antioxidants like resveratrol, NAD+ boosters, and compounds like curcumin have shown potential in fighting oxidative stress, improving cellular repair, and promoting longevity. These supplements can complement a healthy diet and lifestyle, contributing to longer, healthier life.

Lifestyle Factors and Anti-Ageing

While cutting-edge therapies offer exciting possibilities, lifestyle choices remain a cornerstone of healthy aging. Regular physical activity, a balanced diet rich in antioxidants, stress management, and adequate sleep are crucial for maintaining vitality as we age. Practices like intermittent fasting and mindfulness have also been linked to longevity, suggesting that the mind-body connection plays an essential role in how we age.

The Future of Anti-Ageing

While we are still far from achieving immortality, the future of anti-ageing science looks promising. With advancements in genetic research, nanotechnology, and artificial intelligence, we are likely to see more personalized and effective anti-ageing treatments. The hope is that, in the not-too-distant future, we may be able to not only live longer but also enjoy a higher quality of life throughout our extended years.

Ultimately, the journey towards anti-ageing isn’t just about living longer—it’s about living better. Modern solutions are helping us rethink what it means to age, offering a blend of science, technology, and lifestyle choices to achieve a longer, healthier life.

[praneeth8373733]

Exploring Anti-Ageing Innovations for a Healthier, Longer Life

The quest for eternal youth and longevity has been a part of human culture for centuries. From ancient alchemists seeking the "elixir of life" to modern science unlocking the genetic code, the desire to combat the effects of ageing is as old as civilization itself. Today, advancements in technology, medicine, and genetics are driving new anti-ageing innovations that promise a healthier, longer life. Let’s explore some of the most exciting and promising developments in the field of anti-ageing.

Genetic Research and Anti-Ageing One of the most groundbreaking areas of anti-ageing research is genetic science. Over the past few decades, scientists have uncovered fascinating insights into how our genes influence the ageing process. One of the most significant breakthroughs is the discovery of the "longevity gene" — a gene that, when activated, may slow down the ageing process and extend lifespan.

Researchers are also exploring ways to manipulate genes responsible for cellular repair and regeneration. For example, the study of telomeres — the protective caps at the end of chromosomes — has revealed that as telomeres shorten over time, cells lose their ability to divide and regenerate. Scientists are now working on ways to extend the length of telomeres, which could lead to healthier, more youthful cells and a longer life.

Stem Cell Therapy Stem cell therapy is another innovative approach gaining attention in the field of anti-ageing. Stem cells are unique because they have the ability to develop into different types of cells in the body, potentially repairing or replacing damaged tissues. In the context of ageing, stem cell therapy holds promise for rejuvenating organs, tissues, and even the skin.

For instance, stem cell injections have been shown to promote the regeneration of skin cells, improving the appearance of wrinkles and sagging skin. In more severe cases, stem cells are being explored for use in regenerating damaged organs, offering hope for reversing age-related diseases like heart disease and Alzheimer’s.

Senolytics: Targeting Senescent Cells Another exciting area of research involves senolytics, which are compounds designed to target and eliminate senescent cells. These are cells that have stopped dividing and accumulating in the body as we age, often contributing to chronic inflammation, tissue damage, and age-related diseases.

By removing these cells, researchers believe they can help restore tissue function and reduce the physical and mental effects of ageing. Early studies on senolytic drugs have shown promising results, including the potential to reduce frailty, improve muscle strength, and even extend lifespan.

Regenerative Medicine and Organ Transplants Advancements in regenerative medicine are offering new solutions to combat the effects of ageing. The ability to grow organs in laboratories or use 3D printing to create tissue replacements could revolutionize the way we address age-related decline. Rather than relying on traditional organ transplants, scientists envision creating custom-grown organs that could replace failing ones, offering patients the chance to live longer, healthier lives.

Moreover, regenerative therapies are being applied to skin care as well. From bioengineered skin grafts to the use of growth factors that stimulate collagen production, these innovations aim to combat wrinkles and skin damage, making us look as young as we feel.

Nutraceuticals and Anti-Ageing Supplements The rise of nutraceuticals, or food-based supplements, has also contributed to the growing field of anti-ageing. These supplements are packed with ingredients designed to target the biological processes of ageing. Some popular ingredients include resveratrol, NAD+ boosters, and curcumin — all known for their anti-inflammatory and antioxidant properties.

By taking these supplements, individuals may be able to reduce oxidative stress and inflammation, which are major contributors to the ageing process. While research is still ongoing, many people are already incorporating these anti-ageing supplements into their daily routines in hopes of living longer, healthier lives.

Conclusion The innovations in anti-ageing research are promising and continuously evolving, offering exciting possibilities for those who seek to live longer and healthier lives. From genetic breakthroughs to stem cell therapies and regenerative medicine, these cutting-edge developments are pushing the boundaries of what was once considered impossible. As science continues to advance, the future of anti-ageing may hold solutions that will not only add years to our lives but enhance the quality of those years as well.

This article covers various innovative approaches in anti-ageing and longevity, providing an overview of the most promising developments in the field.

[verofax]

Reversing the Clock? Could Dietary Supplements Hold the Key to Extended Lifespan?

The pursuit of longevity has long captivated humanity. Now, groundbreaking research from Dr. David Sinclair at MIT offers a potential paradigm shift: a method to potentially extend human healthspan through cellular rejuvenation. This isn’t science fiction – Dr. Sinclair’s approach focuses on dietary supplements aimed at preventing the buildup of “aging cells,” which contribute to age-related diseases.

Understanding the Science: Targeting Senescent Cells

As we age, our bodies accumulate senescent cells, damaged cells that stop dividing but don’t die. These “zombie cells” secrete harmful substances that disrupt surrounding healthy cells, accelerating aging and contributing to age-related diseases like heart disease, cancer, and Alzheimer’s.

Dr. Sinclair’s research focuses on targeting these senescent cells. His approach utilizes dietary supplements designed to:

Clear Senescent Cells: These supplements might encourage the body’s natural mechanisms to eliminate senescent cells more efficiently.

Prevent Senescence: Supplements could potentially interfere with the processes that cause cells to become senescent in the first place.

The Promise of Dietary Supplements: A Healthier, Longer Life?

If successful, Dr. Sinclair’s approach could revolutionize healthcare. Imagine a future where age-related diseases become less prevalent, and people enjoy a longer period of health and vitality. Here are some potential benefits:

Reduced Disease Burden: By eliminating senescent cells and their harmful effects, the risk of age-related diseases could be significantly reduced.

Extended Healthspan: A longer healthspan translates to more years spent living an active and fulfilling life.

Improved Quality of Life: With a reduction in age-related ailments, individuals could potentially enjoy a higher quality of life well into their later years.

A Note of Caution: Early Days and Important Considerations

While Dr. Sinclair’s research is exciting, it’s crucial to maintain a balanced perspective:

Early Stage Research: Dr. Sinclair’s work is still in its early stages. Extensive clinical trials and safety assessments are needed before these supplements can be widely recommended.

Focus on Healthy Habits: Supplements are not a magic bullet. Maintaining a healthy lifestyle with proper diet, exercise, and sleep remains paramount for healthy aging.

Regulation and Accessibility: As this research progresses, regulations and accessibility considerations regarding these supplements will need to be addressed.

The Future of Aging – A Multifaceted Approach

Dr. Sinclair’s research on senolytics offers a fascinating glimpse into the future of aging. While dietary supplements hold promise, it’s likely that a multifaceted approach will be needed to achieve significant longevity breakthroughs. This may include advancements in other areas like regenerative medicine, gene editing, and personalized healthcare.

Staying Updated on the Longevity Frontier

Dr. Sinclair’s breakthrough research is a significant step towards a future where aging is not a disease but a manageable condition. As the field of longevity research continues to evolve, staying informed about ongoing developments will be key. Keep an eye on this space for further updates on clinical trials, regulatory developments, and the potential impact of Dr. Sinclair’s work on the future of aging.

For more insightful tips and expert advice, follow me on LinkedIn, Facebook, Instagram, Twitter, TikTok, Threads, YouTube channel and stay tuned!

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Blog source: https://verofax.com/blog/reversing-the-clock-could-dietary-supplements-hold-the-key-to-extended-lifespan

[sudheervanguri]

CSIR-Central Drug Research Institute Hiring Project Associate Are you an M.Pharm or MSc graduate in Biochemistry or Zoology looking for a rewarding career in research? CSIR-Central Drug Research Institute (CDRI) is currently hiring Project Associates. Located in Lucknow, this prestigious institute offers an exciting opportunity to work on cutting-edge projects with a team of dedicated professionals. If you have expertise in cell culture, animal handling, and molecular biology, this could be the perfect role for you. CSIR-Central Drug Research Institute Hiring Project Associate - M.Pharm, MSc About the Job Department: Research & Development (R&D) – Active Pharmaceutical Ingredients (API) Position: Project Associate Vacancies: 01 Project Code Number: GAP0475 Project Title: Novel ẞ3-adrenergic agonists as senolytics and insulin sensitizers: Studies in adipose tissue of metabolic dyshomeostasis model systems Scheduled Completion: May 2027 Location: CSIR-Central Drug Research Institute, Lucknow Responsibilities Conduct research and development activities for API projects. Perform synthesis and characterization of organic compounds. Collaborate with cross-functional teams to ensure project success. Document experimental procedures and results accurately. Ensure compliance with regulatory and safety guidelines. Qualifications Degree: M.Pharm with GPAT qualification or MSc in Biochemistry/Zoology with NET/GATE qualification. Experience: Freshers and professionals with relevant experience. Skills: Expertise in cell culture, animal handling (diabetes and obesity models - mice, rat, hamster), histopathological studies, cell and molecular biology. Salary and Benefits Monthly Emoluments: ₹31,000 + 16% HRA Upper Age Limit: 35 years (age relaxation as per Government of India norms) Application Process Interested candidates can apply by filling the Google form provided here. The last date for submitting the application is 18/07/2024, up to 5 PM. Selection Process Screening: The duly constituted Screening Committee will shortlist candidates based on their qualifications and experience. Interview: Shortlisted candidates will be notified via email and will attend the interview (online/offline) as communicated. Important Information The positions are purely temporary, initially for one year, and extendable based on performance and project duration. Engagement in these projects does not confer any right to regularization against any CSIR/CDRI post(s). The number of positions may vary at the time of selection depending on the project requirements. Contact Information For further queries, please contact: Email: info@csir.cdri.in Address: CSIR-Central Drug Research Institute, Lucknow [caption id="attachment_86214" align="aligncenter" width="1200"] CSIR-Central Drug Research Institute Hiring Project Associate[/caption] Instructions To apply for the above post, please go through the Instructions given below and fill the Google Sheet (link given above) All applicants must fulfill the essential qualification for the position and other conditions stipulated in the advertisement as on the last date of submission of application. They are advised to satisfy themselves before applying that they possess at least the essential qualifications laid down for position/positions as on the last date of submission of application. The prescribed essential qualifications are the minimum and the mere possession of the same does not entitle candidates to be called for interview. The duly constituted Screening Committee will adopt its own criteria for short-listing the candidates. The candidate should therefore, mention in the application all the qualifications and experiences in the relevant area over and above the minimum prescribed qualification, supported with. List of shortlisted candidates meeting the criteria (Essential qualification plus criteria set by the committee) shall be notified on the CDRI Website. Date and mode of interview shall be communicated to the shortlisted candidates through e-mail.

The position/s are purely temporary. The engagements shall be initially for a period of ONE YEAR or till the project duration or to the extent funds available, whichever is earlier. The engagements shall be extendable on yearly basis subject to performance review and project duration / funds availability. The engagement of a project staff in different projects either in the CSIR - Central Drug Research Institute, Lucknow or different Lab./Institute of CSIR taken together shall not exceed 5 years in any case. The engagement in these projects will not confer any right implicit or explicit on the candidate for consideration for regularization against any CSIR/CDRI post(s). The number of positions to be recruited may vary at the time of selection depending on the requirement under the project. No TA/DA or allowances will be paid to the candidates for attending the interview. Suitable Candidates may be empaneled for future requirement if any, under same project or different projects of similar nature and requiring candidates with similar essential and desirable qualifications. Age will be reckoned as on the last date of submission of application for this advertisement. Age relaxation will be provided as per Government of India norms. Candidates seeking age relaxation should enclose relevant certificates in prescribed format issued by the appropriate authority as per the latest instructions issued on the subject. Applications (filled in google sheet) submitted after the scheduled date and time shall not be considered for the interview and summarily rejected. The shortlisted candidates shall attend the interview (online/offline), as communicated to the candidate. In case a large number of candidates apply, the Screening Committee may include the additional screening criteria beyond essential and desirable qualifications and shortlist the candidates for interview in proportion to the available vacancies. to interact in English/Hindi before the Selection Committee. Candidate has the option 16) In case the final certificates reflect CGPA/SGPA/OGPA Grades, the candidate should convert the same into an equivalent percentage as per the approved formula of the University in the Google Form, and a copy of such conversion must be attached along with the google form. To avoid any inconvenience, only those candidates who strictly fulfil the eligibility criteria and possess the degree's / mark sheets in the subjects above should apply for the interview. Upon selection, the original documents, including eligibility qualification, DOB, caste, and age relaxation certificate, will be verified. If any discrepancy is found, the selection shall stand cancelled automatically. Advertisement / post may be cancelled at any stage due to force majeure, including closure of project, non-availability of fund, compromised integrity, unethical practices, etc. The decision of the CSIR-CDRI in all matters relating to eligibility, acceptance or rejection of applications, mode of selection, and conduct of examination/interview will be final and binding on the candidates.

[scientificinquirer-blog]

DAILY DOSE: Study Explores Atrial Fibrilation And Elite Athletes; Senolytics Target Zombie Cells in Clinical Trials.

TOUR DE FRANCE CYCLISTS FUEL HEART HEALTH STUDY. On July 1, 2023, as the Tour de France kicked off from Bilbao to the Pyrenees, sports cardiologist Andre La Gerche observed the event keenly from Melbourne. He is particularly interested because some of the leading cyclists are part of his study on the impact of endurance exercise on heart health. The research explores how such activities could…

[knowledgeandinformation]

How not to age

Slowing pathways of ageing

Only about 15-30% of our lifespan appears determined by our genes, which means how we live our lives may determine the bulk of our destiny.

AMPK

Autophagy is a housekeeping process by which defective cellular components are broken down and scrapped for spare parts. AMPK induces autophagy. The most reliable way to extend lifespan may be long term food reduction. AMPK activation is thought to be one of the mechanisms for this longevity boost. Exercise increases the AMPK activity. To help boost AMPK a) reduce consumption of saturated fat (concentrated in meat, dairy and desserts)b) increase consumption of fibre, c) 2 teaspoons of barberries, d) a dash of black cumin, e) hibiscus and/or lemon verbena tea, f) 2 teaspoons of vinegar

Autophagy

To boost this anti-aging pathway, consider a) 60 minutes of moderate to vigorous aerobic activity, b) minimise your intake of fried food, c) consume at least 20mg of spermidine by incorporating foods such as tempeh, mushrooms, peas and wheat germ into your diet, Wheat germ has 2.5mg per tbsp, mushrooms 9.2mg per 100g, tempeh 9.7mg per 100g d) drink three cups of regular or decaffeinated coffee.

Spermidine plays a key role in regulating cell growth. Wheat germ can significantly improve dementia way beyond all available antidimentia treatments so far.

Cellular senescence

To prevent cellular senescence, avert DNA damage by following the recommendations in the oxidation chapter and to clear such cells of their SASP there are natural senolytic compounds in foods (quercetin, fisetin and piperlongumine). While it is not yet clear whether sufficien levels can be reached by eating foods rich in these compounds, the foods are healthful in their own right. To slow this aging pathway, consider a) consuming quercetin-rich foods, beverages and seasonings such as onions, apples, kale, tea and salt free capers, b) eating strawberries, c) seaoning meals with pippali.

Epigenetics

Exercise frequency and intensity are associated with a deceleration of aging. In 2018 an aging analysis was published of the CALERIE study, the first major randomised trial of calorie restriction in humans. The control group continued to age at a rate of about one year per year but in that time the dietary restriction group only aged by about one month. And they achieved this with only a 12% calorie restriction. Aging rates were slowed independent of weight loss.

The lifestyle factor most closely associating with slowing aging, even more than exercise, is a marker of fruit and vegetable intake, blood levels of carotenoid phytonutrients like beta-carotene. The food most consistently linked to accelerating aging is meat.

To help boost this anti-aging pathway, restrict calories by 12% which would be cutting about 250 calories out of a 2000 calorie diet, and b) meeting the 400μg recommended daily allowance of folate, which could be achieved with about a cup of cooked lentils or edamame, a cup and a half of cooked spinach or asparagus, or two and a half cups of broccoli.

Glycation

Advanced glycation end products (AGEs) are one of the main factors contributing to the aging process. As AGEs accumulate in our bones, joints and muscles, they may contribute to osteoporosis, arthritis and muscle asting, the weaking, shrinking and loss of muscle mass with age. AGEs are implicated in age related memory decline, impaired wound healing, skin aging, cataracts and Alzheimer's disease.

Eating an AGE less diet by emphasising lower AGE foods such as fruits and vegetables, cooking high protein foods using relatively low heat and high humidity methods such as boiling or steaming rather than broiling or frying, favouring raw nuts and seeds over roasted or toasted, choosing lower glycemic load foods. Steel cut oats are a low glycemic index food but instant oats are high.

IGF-1

The higher the IGF-1 in your bloodstream, the higher your risk for developing some cancers such as breast, colorectal and prostate.

Inflammation

Chronic inflammation is systemic, persistent and non-specific and appears to perpetuate disease. A marker is C-reactive protein. Immunity deteriorates with age in a process known as immunosenescence. There is also more inflammation. The progressive increase in pro-inflammatory status is a major feature of the aging process and is referred to as "inflammaging". Applying skin lotion twice daily may be a simple way to dampen systemic inflammation. Some causes of inflammation are the buildup of dietary advanced glycation end products, senescent cells spewing SASP and age related decline in autophagy machinery. Two years of modest caloric restriction cut inflammation markers such as CRP by 40%, which could have been due to a boost in autophagy that cleared out inflammatory cellular debris or simply as a consequence of their weight loss. Fatty tissue plays an active role in secreting inflammatory chemicals. Dietary cholesterol may contribute to inflammation. As we age, there is an increate in visceral fat which may contribute to inflammaging.

Dietary Inflammatory Index: generally components of animal products and processed foods like saturated fat, trans fat and cholesterol were found to be pro-inflammatory, while constituents of whole plant foods such as fiber and phytonutrients came up strongly anti-inflammatory. Eating a more inflammatory diet has been associated with 75% increased odds of having cancer and 67% increased risk of dying from it.

mTor

Suppression of mTOR may be a central mediator of the lifespan-extending effects of dietary restriction. Caloric restriction has been heralded as a fountain of youth but negative side effects may include dangerously low blood pressure, infertility, slower healing of wounds, menstrual irregularities, sensitivity to cold and loss of strength, bone and libido. You're also walking around starving all the time. However the benefits of eating less may not be coming from restricting calories but from restricting protein. Methionine and the three branch-chain amino acids (BCAA) isoleucine, leucine and valine are particularly important to restrict, and they are particularly concentrated in animal proteins. A compound called DIM, formed when the cruciferous vegetable compound indole-3-carbinol hits our stomach acid, has been shown to suppress mTOR activation. Sulforaphane, another product of consuming cruciferous vegetables, also suppresses mTOR. Also coffee and green tea. To slow this aging pathway, strive to stick to the recommended daily intake of protein, 0.8g per healthy kg of body weight which translates to about 45g a day for the average-height woman.

Oxidation

Free radicals are unstable, violently reactive molecules with an unpaired electron. The unpaired electron steals electrons away from any molecule in their path. The resultant cellular damage causes aging. Mitochondria are the major source of cellular free radical formation. You can reduce mitochondrial free radical production rate through exercising and by lowering intake of the amino acid methionine. Methionine restriction is thought to account for about 50% of the lifespan extension attributed to full dietary restriction. Legumes have a comparably low methionine content. This is consistent with legume consumption being the most important dietary predictor of survival in older people around the world. Antioxidants can't seem to slow the rate of aging but they may be able to prevent age-related diseases linked to oxidative damage to the 99% of our DNA outside the mitochondria. Oxidative stress has been implicated in hair graying, the development of cataracts, arthritis, frailty and neurodegenerative, cardiovascular, kidney and pulmonary diseases, cognitive decline, age-related macular degeneration and muscle loss. Every meal is an opportunity to tip the balance in a pro-oxidant or antioxidant direction. Eating a single meal deficient in antioxidant-rich foods can leave us in a pro-oxidant state for hours. You can also experience increased oxidative stress due to illness, secondhand smoke, air pollution and sleep deprivation. Antioxidant levels can plummet within 2 hours of a stressful event and take up to 3 days to get back to normal. So healthier eating is especially important when we anticipate we'll be stressed, sick or tired. Kiwis, cooked carrots and green tea are particularly good at facilitating DNA repair. Red wine can improve blood antioxidant capacity. Nrf2 levels and signaling tend to decrease with age. 30 mins of cycling can boost them but the most potent natural Nrf2 inducer is sulfurophane (in cruciferous vegetables). B12 deficiency is associated with increased oxidative stress. To slow oxidation, consider daily exercising, restrict methionine intake by choosing plant based protein sources and reducing overall protein intake to recommended levels, activate Nrf2 defenses by eating green/ cruciferous vegetables and drinking green tea, eating berries and other naturally vibrantly coloured foods, using herbs and spices, avoiding added salt, sugar and saturated fat- and cholesterol-rich foods.

Telomeres

Telomeres are one of the aging pathways that have crept into the public consciousness. Increasing telomere length to slow or even prevent aging is a popular idea, though the science is controversial. Telomere elongation is possible through activation of the telomerase enzyme, but there is a constant battle between the forces hacking away at our telomeres such as aging, oxidative stress and inflammation and the lifestyle decisions that can help build them back up. To help boost this anti-aging pathway, on a daily basis consider: a) following the recommendations in the inflammation and oxidation chapters, b) eating a high-fibre diet centered around whole plant foods, drink tea and coffee, eat cruciferous vegetables, supplement with 800 to 1000 IU of vitamin D3 a day if your vitamind D blood level is under 20 ng/mL.

Lifestyle

Weight

BMI of 20 to 22 is the optimal weight for longevity (53-58kg for 5ft4).

Sleep

Sleep deprivation is no joke. The magnitude of impairment from a week of five-hour nights is similar to that reported in people who smoke, have diabetes or have coronary artery disease. There are some alarming contaminants in melatonin supplements. Pistachios are not just the most melatonin-rich nut, they are simply off-the-charts as the most melatonin-rich food ever recorded. To get a physiological dose of melatonin, all you have to eat is two pistachios.

Salt

Between 40 and 70 food intake drops by about a quarter due to a declining appetite. We also start losing our taste buds and sweet and salty tastes are often the first to slip, which can lead to diets particularly excessive in sugar and salt.

Preserving function

Bones

Inflammation and oxidative stress may play a role in osteoporosis. The intake of pro-inflammatory foods and an elevation of inflammatory markers in the blood such as C-reactive protein are both associated with osteoporotic fractures. A higher intake of fruits and vegetables is associated with lower fracture risk. The consumption of vitamin-C rich foods is associated with lower risk of bone loss, osteoporosis and hip fracture. Soy foods have been significantly associated with lower risk of fracture.

Nutritionally, soy milk is the best choice for replacing dairy milk in the human diet.

Bowel

Fibre.

Circulation

The capacity of our blood vessels to repair themselves is dependent on endothelial progenitor cells that emerge from stem cells in our bone marrow to patch up any holes in our endothelium, the innermost lining in our blood vessels that keeps our blood flowing smoothly. Reduce trans fat (mostly in meat and dairy), saturated fat (animal products and junk foods. also coconut oil palm oil) and dietary cholesterol (animal products, particularly eggs). Increase berries, onions, green tea. Eat plant based.

Immune system

Vaccination is less effective for the elderly. For example, while flu shots can build up sufficient antibody protection in 50-70% of younger individuals, that proportion falls to as few as 10-30% of older adults who are among those who need the protection the most. Also, the immune cells of elderly produce significantly more pro-inflammatory signals. This suggests the worst of both worlds - a decline in the part of the immune system that fights specific infections and an aggravation of nonspecific overreactions that can lead to inflammation. Immunosenescence is the decline in immune defense with aging. Exercise helps to improve efficacy of flu and pneumonia vaccines. Sleep improves the ability to clear viruses more quickly so you're less likely to become symptomatic. Those who eat more fruits and vegetables have a lower risk of getting an upper respiratory tract infection like the common cold. Those eating five or more servings of fruits and vegetables had an 82% greater protective antibody response to a flu vaccine than those who didn't. Disappointing trial results for echinacea. Kiwifruits, broccoli significantly shorten flu duration. Maybe seaweed and soy milk. Mushrooms, particularly shiitake. Nutritional yeast. Green tea. Fibre.

Joints

Athletic injuries to the knees are a well established risk factor for osteoarthritis later in life. At the same time, physical inactivity can put your knees at risk, not only because weakened muscles make for less stable joints but because cartilage also has a "use it or lose it" characteristic. Exercise is consistently effective for pain relief if you have osteoarthritis.

Dietary factors associated with accelerated progression: higher saturated fat intake, dietary cholesterol, pro-inflammatory omega-6 fat, pro-inflammatory diets.

Reduced acceleration: anti-inflammatory diet, fibre, green tea, strawberries. Ginger, turmeric (1/2 tsp daily). No evidence for glucosamine, chondroitin or collagen.

Muscles

Muscle mass starts to decline after 30 and accelerates after 50 at a loss of 1-2% every year. Not just because people become less active with age. Frailty is comprised of weakness, unintentional weight loss, exhaustion, slow walking speed and low physical activity. The heritability of muscle mass and strength is around 50%. Use it or lose it applies to muscle. Eating high on the Dietary Inflammatory Index has been associated with frailty. The recommended dietary allowance of protein is 0.8g of protein per ideal kg of body weight per day. Extra protein or essential amino acid supplementation appears to have little or no effect on muscle mass, strength or performance when taken alone or added to an exercise regimen. Whey protein stimulates the greatest response in terms of short term muscle protein synthesis but there is no correlation between this and long term changes in muscle mass. Higher fruit and vegetable intake linked to lower frailty. Creatine is effective if combined with exercise.

Skin

The three main constituents that make up the bulk of our skin are collagen, hyaluronic acid and elastin. As we age, the synthesis of collagen and elastin decreases by about 1% a year as does skin thickness. Intrinsic aged skin loses elasticity and develops fine wrinkles but is generally otherwise smooth and unblemished but extrinsic skin becomes leathery, bumpy, blotchy and mottled with coarse wrinkles and furrows. Between 80-90% of facial aging of those with light skin is due to sun exposure.

Fibre for varicose veins. Minimise sun exposure and use sunscreen to prevent skin cancer. Sunscreen to prevent skin aging, retinol to reverse aging. Nicotinamide for wrinkles. Vitamin C for oxidative stress but shelf stable versions aren't effective so buy L-ascorbic acid and mix 3g into 30g water and use a few drops on face daily. Collagen supplements haven't been shown to be effective. Stimulate collagen synthesis by ensuring a daily vitamin C intake of at least 95mg (an orange or a cup of broccoli have 70mg). Foods which may be defensive against wrinkles are antioxidant rich foods, anti-inflammatory foods, anti-glycation foods, fibre rich foods and foods shown to block collagen- and elastin- destroying enzymes such as garlic, turmeric and ginger.

Teeth

Green tea as a mouthwash, with or without added amla? Sugar consumption is considered to be the one and only cause of cavities. Superior dental health among vegetarians may be due to eating fewer pro-inflammatory foods or more anti-inflammatory components like high fibre diets. But vegetarians do have an increased risk of dental enamel erosion due to the consumption of more acidic fruits and vegetables such as citrus and tomatoes. The solution is to rinse out your mouth with water after consuming sour foods or beverages and waiting 30-60 minutes after consumption to allow your teeth to first remineralise. Flossing before brushing is much better for plaque removal than after. Nitrates may play an important antimicrobial role in saliva which alleviates gum inflammation.

Vision

Prevent cataracts with spring greens, spinach and goji berries.

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Unlocking the Secrets of Lifespan Extension: Exploring Strategies for Prolonging Vitality

Introduction:

The Quest for Lifespan Extension

In a world where scientific advancements are continually pushing boundaries, the quest for lifespan extension has become a prominent topic of exploration. As humanity strives to unlock the secrets of longevity, researchers are delving into various strategies aimed at prolonging vitality. This article will explore key approaches and breakthroughs in the field of lifespan extension.

Understanding the Biological Basis:

Decoding the Aging Process

Before diving into strategies for lifespan extension, it's crucial to understand the biological basis of aging. Aging is a complex process influenced by genetic, environmental, and lifestyle factors. At the cellular level, the accumulation of damage, deterioration of DNA, and the decline in cellular functions contribute to the aging phenotype.

Strategies for Lifespan Extension:

Nutritional Interventions

One avenue gaining significant attention is nutritional interventions. Caloric restriction, for instance, has shown promise in extending lifespan in various organisms. Studies suggest that reducing calorie intake without malnutrition activates molecular pathways associated with longevity, promoting cellular repair and resilience.

The Role of Dietary Supplements

Certain dietary supplements, such as resveratrol and NAD+ precursors, have demonstrated potential in promoting cellular health and longevity. These compounds activate sirtuins, a class of proteins linked to various cellular processes, including DNA repair and energy metabolism.

Genetic Approaches

Advancements in genetic engineering have opened new possibilities for extending lifespan. Gene editing technologies like CRISPR-Cas9 enable scientists to manipulate specific genes associated with aging. Researchers are exploring the potential of enhancing cellular repair mechanisms and slowing down the aging process through targeted genetic interventions.

Telomere Extension and Cellular Senescence

Telomeres, protective caps at the end of chromosomes, naturally shorten with each cell division, contributing to cellular aging. Scientists are investigating ways to extend telomeres, delaying cellular senescence. Strategies like telomerase activation aim to maintain telomere length and promote cellular longevity.

Senolytics - Clearing Aging Cells

Senescent cells, which have ceased to divide and accumulate with age, contribute to tissue dysfunction. Senolytic drugs target and eliminate these aging cells, promoting tissue rejuvenation. Research in this area explores the potential of senolytics in delaying age-related diseases and extending healthy lifespan.

Hormonal Interventions

Hormones play a crucial role in regulating various physiological processes, and their decline with age is associated with several aging-related issues. Hormonal interventions, such as hormone replacement therapy, are being investigated for their potential in extending healthspan and mitigating age-related conditions.

Growth Hormone and Longevity

Studies on growth hormone suggest a complex relationship with aging. While excessive levels may accelerate aging, optimizing growth hormone levels in a controlled manner may have positive effects on muscle mass, fat distribution, and overall vitality.

Ethical Considerations and Challenges:

Balancing Progress and Ethical Concerns

As scientists make strides in the quest for lifespan extension, ethical considerations become paramount. Questions surrounding access to life-extending technologies, potential socio-economic implications, and the definition of a "good" or "meaningful" life in an extended lifespan scenario must be addressed.

The Challenge of Long-Term Studies

Conducting long-term studies on lifespan extension presents a significant challenge. The human lifespan is inherently lengthy, making it difficult to observe the effects of interventions over several decades. Researchers face the task of designing studies that can provide meaningful insights within a reasonable timeframe.

Conclusion:

Navigating the Future of Lifespan Extension

In the pursuit of unlocking the secrets of lifespan extension, a multidisciplinary approach involving genetics, nutrition, and hormonal interventions is revealing promising avenues. As science continues to advance, ethical considerations will guide the responsible development and implementation of life-extending technologies. The journey towards a longer, healthier life is complex, but the potential benefits for individuals and society as a whole make it a journey worth taking.

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Cutting-edge Research on PAH and IPF: New Discoveries and Promising Treatments

Cutting-edge Research on PAH and IPF: New Discoveries and Promising Treatments https://ift.tt/wvKdQyO Pulmonary arterial hypertension (PAH) and idiopathic pulmonary fibrosis (IPF) are debilitating and life-threatening lung diseases affecting millions worldwide. Despite significant medical research and treatment advances, these conditions remain challenging, and effective therapies are limited. However, recent cutting-edge research has uncovered discoveries and promising treatments that could revolutionize how we approach PAH and IPF. PAH is a progressive disorder affecting the blood vessels in the lungs, leading to increased blood pressure and strain on the heart. IPF is a chronic and irreversible lung disease characterized by having buildup of scar tissue in the lungs, which impairs breathing and oxygenation. While PAH and IPF have distinct causes and manifestations, they share some underlying biological mechanisms and clinical features, such as inflammation, oxidative stress, and impaired endothelial function. One recent breakthrough in PAH research is the discovery of a novel therapeutic target called endothelial-to-mesenchymal transition (EndMT). EndMT is a cellular process that transforms endothelial cells into mesenchymal cells, contributing to fibrosis and vascular remodeling in PAH. By targeting EndMT, researchers have identified several promising drugs, such as Rho-kinase and TGF-beta inhibitors, that could prevent or reverse the pathological changes in the lung vasculature and improve outcomes for PAH patients. Similarly, in IPF research, recent studies have shed light on the role of senescent cells, which have lost the ability to divide and proliferate but remain metabolically active and secrete harmful substances. Senescent cells accumulate in the lungs of IPF patients and contribute to the progression of fibrosis and inflammation. Therefore, targeting senescent cells with drugs or gene therapies, such as senolytics or telomerase activators, could slow down or reverse the disease process in IPF. Another exciting area of research in both PAH and IPF is the development of precision medicine and personalized therapies. By analyzing individual patients’ genetic, epigenetic, and molecular profiles, researchers can identify specific subtypes or biomarkers associated with different disease stages, responses to treatment, and outcomes. This information can then be used to tailor treatment strategies that target the underlying mechanisms of the disease and maximize the therapeutic benefits while minimizing the risks and side effects. Cutting-edge research on PAH and IPF advances our understanding of these complex and devastating lung diseases and opens up new avenues for treatment and prevention. While there is still much to learn and explore, the discoveries and innovations in this field show promise for improving the lives and outcomes of patients with PAH and IPF. The post Cutting-edge Research on PAH and IPF: New Discoveries and Promising Treatments first appeared on Lahouaria Hadri | Science. via Lahouaria Hadri | Science https://ift.tt/cn3P4uS January 08, 2024 at 10:21AM