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Microbiota "revolution": in the gut matrix and its bad "sentients programs", there are also good chances to enhance the good ones
The “sweet” issue for public health According to the International Diabetes Federation Diabetes Atlas (9th edition), approximately 463 million adults globally suffer from diabetes. This number is projected to rise to 578 million (10.2% of the total population) by 2030, making diabetes one of the most serious threats to human health in the 21st century. The global prevalence of T2DM is increasing,…
#Akkermansia#Bifidobacterium#cardiovascular risk#chronic inflammation#dietary habits#dysbiosis#Enterobacteria#gut community#lactobacilli#lifestyle#metformin#microbiota#Ruminococcus#short chain fatty acids#type 2 diabetes
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Gut Microbiome Test | FMD
The key to overall well-being heavily depends on the gut microbiome, an ever-evolving community of billions of bacteria thriving within our digestive system. Bacteria, viruses, fungi, and other microorganisms make up this complex ecosystem, which has a significant impact on immunity, digestion, and even mental health.
Its functioning depends on the diversity of the gut microbiota. In addition to supporting the immune system by protecting against hazardous intruders, a diverse and abundant microbial community also helps break down complex nutrients. The influence of the microbiome on mental health is further demonstrated by recent studies, which point to its possible involvement in disorders including anxiety and depression.
For optimum health, it is important to maintain a healthy gut microbiome. This complex ecology is shaped by a person's diet, lifestyle, and surroundings. A healthy microbial community is promoted by including foods high in fiber, fermented foods, and probiotics in one's diet. On the other hand, this delicate equilibrium may be upset by overusing antibiotics or by eating a diet heavy in processed foods.
Good & Bad Bacteria in The Gut
Numerous different types of bacteria reside in the human gut, and they are essential to our general well-being. There are "bad" and "good" bacteria in this intricate ecosystem, each having a different role and impact on human health.
Positively, "good" bacteria, also known as probiotics, aid in immune system regulation, nutrition absorption, and digestion. These helpful bacteria aid in the breakdown of complex carbohydrates, the synthesis of vital vitamins, and the creation of an unfavorable environment for invading organisms. Lactobacillus and Bifidobacterium, which are present in yogurt and fermented foods, are two common examples.
On the other hand, pathogenic or "bad" bacteria can upset the delicate equilibrium of the gut microbiome. These dangerous bacteria can weaken the immune system, induce inflammation, and create digestive problems when they multiply. Disturbances in the microbiota of the gut, frequently brought on by unhealthy eating habits or overuse of antibiotics, can result in disorders including inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS).
Encouraging the development of helpful bacteria while limiting the proliferation of dangerous ones is essential to maintaining a healthy gut balance. A balanced gut microbiota may be achieved by eating a varied and high-fiber diet, including foods high in probiotics, and refraining from overusing antibiotics. Maintaining this equilibrium makes sure that our gut's billions of bacteria cooperate to promote healthy digestion, absorption of nutrients, and general well-being.
Interesting Facts About Gut Microbiome
Microbial Metropolis: The gut is home to trillions of microorganisms, collectively known as the gut microbiome. This bustling community includes bacteria, viruses, fungi, and other microbes, creating a diverse ecosystem within our digestive tract.
Microbial Census: The number of microbial genes in the gut is estimated to be around 150 times greater than the number of human genes. This emphasizes these microorganisms' significant impact on our biology and overall health.
Personalized Microbial Fingerprint: Each person's gut microbiome is unique, akin to a personalized microbial fingerprint. Genetics, diet, environment, and lifestyle contribute to this individualized composition.
Brain-Gut Connection: The gut microbiome communicates with the brain through the gut-brain axis, influencing mood, behavior, and even cognitive function. This bidirectional communication emphasizes the gut's role in mental health.
Weighty Matters: The gut microbiome has been linked to weight management. Certain microbial species are associated with lean individuals, while an imbalance may contribute to weight gain and obesity.
Microbial Diversity Matters: A diverse gut microbiome is generally a healthy one. A rich microbial community supports various functions, including efficient digestion, nutrient absorption, and a robust immune system.
Microbial Maturation: The development of a newborn's gut microbiome begins at birth and continues through early childhood. Factors like delivery method (vaginal vs. cesarean), breastfeeding, and exposure to microbes shape its maturation.
Probiotics and Prebiotics: Probiotics, beneficial live bacteria, and prebiotics, which are compounds that nourish these bacteria, contribute to a balanced gut microbiome. Foods like yogurt, kefir, and fiber-rich vegetables support gut health.
Gut Microbes and Immunity: A significant portion of the immune system is located in the gut. The gut microbiome plays a crucial role in training the immune system, helping it distinguish between harmful and harmless substances.
Gut-Heart Connection: Recent studies suggest a link between the gut microbiome and cardiovascular health. Imbalances in the gut may contribute to conditions like atherosclerosis and hypertension, highlighting the systemic impact of gut health.
Gut Microbiome Test
Discover the wonders of your body with a Gut Microbiome Test – your personal guide to understanding what's going on inside. Your gut is like a tiny universe, filled with trillions of microorganisms. This test helps you learn about them in a way that's all about you. It's not just about digestion – find out how your gut buddies can affect your mood and even your weight. Learn which foods can be your best pals for a healthy gut. This test is like a sneak peek into your future health, helping you catch potential issues early. It's an investment in feeling good and staying well.
Start a journey to well-being with the First Medical Diagnostics Gut Microbiome Test – a unique tailored diagnostics test to understand your gut health. We collect blood samples from the comfort of your home. The sample collection process is done precisely using a special kit from Germany. After the sample is collected, we send it to the laboratories in Germany, and within three weeks the report is shared with the patient. Furthermore, we offer comprehensive counseling sessions to patients to guide them in achieving their well-being. The thorough counseling that comes after, in addition to the accuracy of the tests, is what distinguishes First Medical Diagnostics. This is about learning the unique language of your body, not simply about numbers. The report turns into a road map that points you in the direction of foods that balance your microbiota and lifestyle changes that will make you healthy.
This is a collaboration with professionals who genuinely care about your health; it's not your typical health test. It's an adventure that starts at home and travels across borders to link you with knowledge from across the world. Because there is no one-size-fits-all solution when it comes to your health, go with the First Medical Diagnostics Gut Microbiome Test.
For more information,
Call us at +91 8800929600
Visit us at www.fmdindia.in
#fmdindia#microbiomes#FMD#thyroid#rheumatoidarthritis#diabetes#irritablebowelsyndrome#constipation#insomnia#diarrhea#heartburn#bloating#akkermansia#bacteroides#bifidobacterium#christensenella#eubacterium#lactobacillus#ruminococcus#enterobacteriaceae#enterococcus
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#living with lupus#lupus symptoms#chronic inflammation#autoimmune#gut microbiome#ruminococcus gnavus
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Microorganisms, Vol. 12, Pages 1225: Periodontal Inflammation and Dysbiosis Relate to Microbial Changes in the Gut
Periodontal disease (PerioD) is a chronic inflammatory disease of dysbiotic etiology. Animal models and few human data showed a relationship between oral bacteria and gut dysbiosis. However, the effect of periodontal inflammation and subgingival dysbiosis on the gut is unknown. We hypothesized that periodontal inflammation and its associated subgingival dysbiosis contribute to gut dysbiosis even in subjects free of known gut disorders. We evaluated and compared elderly subjects with Low and High periodontal inflammation (assessed by Periodontal Inflamed Surface Area (PISA)) for stool and subgingival derived bacteria (assayed by 16S #rRNA sequencing). The associations between PISA/subgingival dysbiosis and gut dysbiosis and bacteria known to produce short-chain fatty acid (SCFA) were assessed. LEfSe analysis showed that, in Low PISA, species belonging to Lactobacillus, Roseburia, and Ruminococcus taxa and Lactobacillus zeae were enriched, while species belonging to Coprococcus, Clostridiales, and Atopobium were enriched in High PISA. Regression analyses showed that PISA associated with indicators of dysbiosis in the gut mainly reduced abundance of SCFA producing bacteria (Radj = −0.38, p = 0.03). Subgingival bacterial dysbiosis also associated with reduced levels of gut SCFA producing bacteria (Radj = −0.58, p = 0.002). These results suggest that periodontal inflammation and subgingival microbiota contribute to gut bacterial changes. https://www.mdpi.com/2076-2607/12/6/1225?utm_source=dlvr.it&utm_medium=tumblr
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The gut microbiota and tumor-associated macrophages (TAMs) affect tumor responses to anti–programmed cell death protein 1 (PD-1) immune checkpoint blockade. Reprogramming TAM by either blocking or deleting the macrophage receptor triggering receptor on myeloid cells 2 (TREM2) attenuates tumor growth, and lack of functional TREM2 enhances tumor elimination by anti–PD-1. Here, we found that anti–PD-1 treatment combined with TREM2 deficiency in mice induces proinflammatory programs in intestinal macrophages and a concomitant expansion of Ruminococcus gnavus in the gut microbiota. Gavage of wild-type mice with R. gnavus enhanced anti–PD-1–mediated tumor elimination, recapitulating the effect occurring in the absence of TREM2. A proinflammatory intestinal environment coincided with expansion, increased circulation, and migration of TNF-producing CD4+ T cells to the tumor bed. Thus, TREM2 remotely controls anti–PD-1 immune checkpoint blockade through modulation of the intestinal immune environment and microbiota, with R. gnavus emerging as a potential probiotic agent for increasing responsiveness to anti-PD-1.
TREM2 deficiency reprograms intestinal macrophages and microbiota to enhance anti–PD-1 tumor immunotherapy | Science Immunology
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Comparative genomics reveals extensive intra-species genetic divergence of the prevalent gut commensal Ruminococcus gnavus
http://dlvr.it/SsvxRV
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Letter to the Editor
Faecalibacterium prausnitzii over ASVs related to species in the genus Bacteroides (B. dorei, B. massiliensis and B. thetaiotaomicron) (figure 1E), which provided an area under the curve (AUC) of 0.863 for differentiating individuals with PASC from RC. Balance values also negatively correlated with IL-6 (r=−0.44, p=0.01). These microbiome differences are consistent with Liu et al,1 who also reported higher levels of Bacteroides (B. vulgatus specifically) and lower F. prausnitzii with PASC. Liu et al also reported higher Ruminococcus gnavus with PASC, and lower Collinsella aerofaciens, and Blautia obeum. Interestingly, an ASV highly related to R. gnavus (100% identity over V4 read) correlated positively with IL-6 and ASVs related to F. prausnitzii (98.7% ID), C. aerofaciens (100% ID) and B. obeum (100% ID) all negatively correlated with IL-6 and/or CRP levels in our study
A mechanistic link between microbiome differences and high inflammation in PASC is supported by studies showing anti-inflammatory effects of F. prausnitzii5 and proinflammatory effects of R. gnavus.6 Higher levels of particular Bacteroides and R. gnavus in PASC may also be interesting because R. gnavus, B. thetaiotaomicron and B. vulgatus all produce sialidases that can liberate sialic acids from host mucin.7–9 B. thetaiotaomicron can also increase the ratio of sialylated to sulfated mucins in mono-associated rats, and this effect was diminished by co-colonisation with F. prausnitzii.10 Sialic acids may be important in SARS-CoV-2 pathogenesis because the receptor-binding domain of the spike protein recognises sialic acid-containing oligosaccharides.11 Increased levels of microbially liberated sialic acids could support immune evasion by SARS-CoV-2 when free sialic acids bind to the spike protein; sialic acids are used for host immune evasion by multiple bacterial pathogens.12 Sialidase and sialyltransferase inhibitors have been effective in influenza prophylaxis and symptom relief,13 and also prevented pathogen outgrowth due to liberation of sialic acids from gut mucins by B. vulgatus in mice8, suggesting that, if experimentally validated, sialidase inhibition has therapeutic potential for PASC.
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Las erupciones de #lupus pueden estar asociadas con el aumento de una #bacteria específica intestinal. El reciente trabajo realizado en sesenta mujeres enfermas de #lupus permitió estudiar la particularidad de su microbiota intestinal. Los resultados confirman que las fases de desequilibrio de la microbiota coinciden con las fases de actividad de la enfermedad. La bacteria responsable: #Ruminococcus gnavus Los investigadores consiguieron identificar una bacteria, Ruminococcus gnavus, cuya superabundancia muestra una correlación positiva con la actividad de la enfermedad. Este desequilibrio va acompañado de una alteración de la barrera intestinal, que aumentaría la exposición del sistema inmunitario a las bacterias digestivas, algunas de ellas patógenas. www.microbiotico.com 01 (81) 8850-7840 y 41 (en Dr. Christian Cornejo - Restaurart.mx) https://www.instagram.com/p/Bx43wgzgD0m/?igshid=8tkfsseonvog
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Rettocolite ulcerosa: se mancano batteri all'appello, allora la soluzione è rimetterli
Rettocolite ulcerosa: se mancano batteri all’appello, allora la soluzione è rimetterli
La colite ulcerosa è un tipo di malattia infiammatoria intestinale analoga alla malattia di Chron. Diversamente da ciò, tuttavia, provoca infiammazione e piaghe nell’ultimo tratto dell’intestino crasso, che può provocare dolore addominale, perdita di peso, diarrea contenente pus o sangue e altri problemi. I sintomi della colite ulcerosa possono variare da lievi a gravi e attualmente non esiste…
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#acidi biliari#autoimmunità#batteri#colite cronica#dolore#flogosi cronica#infiammazione#intervento chirurgico#intestino#microbiota#mucosa intestinale#poliposi familiare#rettocolite#rettocolite ulcerosa#Ruminococcus
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Saki the succubus
#Saki the succubus full#
studioHIP-CATs is best known for the art of the manga Saki the Succubus Hungers Tonight. The inoculation loop was dipped in the ooze and streaked on Triphenyltetrazolium Chloride (TZC) (Himedia) media. Mikokuno Homare is a Japanese writer best known for the manga Saki the Succubus Hungers Tonight. The small pieces were placed in distilled water for 10 to 15 minutes. Isolation of Ralstonia solanacearum The outer parts of infected material were removed with a sterilized scalpel. This bacterium is commonly found in tropical, sub-tropical and warm temperate climates, but is not believed to survive cold temperatures such as those typical of Wisconsin winters. Ralstonia wilt is caused by the bacterium Ralstonia solanacearum (formerly Pseudomonas solanacearum). hentai vertical video masturbation verified amateurs exclusive amateur succubus fetish pussy pussy stuffing. Please use the Bookmark button to get notifications about the latest volumes. Enjoy Stuffing pussy with hentai shirt Video. READ Is Ruminococcus Flavefaciens harmful or helpful? How long does bacterial wilt live in soil?īacterial wilt is both a soilborne and a waterborne disease, meaning that the pathogen can survive in soil for up to two years after the crop harvest (Shamsuddin et al., 1978), and in water for up to four years (Alvarez et al., 2008 Hong et al., 2008) in the absence of a host. Youre reading Saki the Succubus Hungers Tonight Volume 1 at. The bacteria were first named Bacillus solanacearum. It can be readily spread through the movement of contaminated soil and infected vegetatively propagated plants, in contaminated irrigation water, and on the surfaces of tools (cutting knives) and equipment used to work with the plants, and on soiled clothing. How do you identify Ralstonia solanacearum?įIGURE 1 Ralstonia solanacearum distinctive symptoms and signs on representative hosts: A, unilateral yellowing and wilting of tobacco plant in the field B, the stem-streaming test C, wilting of tobacco leaves in the field D, reddish to brown discoloration of the vascular tissue on tobacco stem E, wilting and … How is Ralstonia solanacearum treated?Ī heat treatment at either 45☌ for 2 d or a minimum temperature of 60☌ for 2 h of the infected soil prior to tomato planting reduced the total bacterial population by 60–97%, that of Ralstonia sp. The species as a whole has a very broad host range and infects hundreds of species in many plant families. studioHIP-CATs is bestknown for the art of the manga Saki the Succubus HungersTonight.Ralstonia solanacearum is a widely distributed pathogen found in tropical, subtropical, and some temperate regions of the world (3). She's in for a surprise when Renta pulls her into theclosest building to escape the downpour-and it turns out to be a love hotel! ContributorBio: Mikokuno Homare is a Japanesewriter best known for the manga Saki the Succubus HungersTonight. There she meets Yui, a human who hates demons. Richille, a fallen succubus who lacks sensuality and magical powers is sent to the human world to learn about seduction. Stuck outside in a freak rainstormand soaked to the bone, she chases after Renta to set the record straight andconfess her own love. A succubus is a demon who feeds on mens life energy. And then,even worse, Saki gets left out in the rain. Renta is reaping the benefits of having a succubus as a roommate, but a whole new problem has fallen into his lap: Saki has avoided harvesting his essence. When she findsherself with an opportunity to move in with a 30-something man who's never sleptwith a woman before, she takes it, just like she'll takehim! VOLUME SUMMARY: Saki is left out in thecold when rival succubus Mami confesses her feelings for Renta first. A new supernatural romance manga about a succubus-in-training Saki-chan is a beautiful young woman and just a little naive. She may seem harmless as she wanders the streets, but bewareshe’s a brand-new succubus who thrives on the lust of men She’s justnot very good at it yet. She may seemharmless as she wanders the streets, but beware-she's a brand-new succubus whothrives on the lust of men! She's just.not very good at it yet. 3.557 out of 5 from 66 votes Rank 21,315 Saki-chan is a beautiful young woman and just a little naive.
#Saki the succubus full#
Read full overviewĮnjoy a sweet roommate romance in this Mature-rated manga about a succubus-in-training! Saki-chan is a beautiful young woman and just a little naive. She may seemharmless as she wanders the streets, but beware-she's a brand-new succubus whothrives on. Enjoy a sweet roommate romance in this Mature-rated manga about a succubus-in-training! Saki-chan is a beautiful young woman and just a little naive.
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Nutrients, Vol. 16, Pages 891: Gastrointestinal Microbiota & Symptoms of Depression and Anxiety in Anorexia Nervosa—A Re-Analysis of the MICROBIAN Longitudinal Study
The microbiota–gut–brain axis may play a role in the pathophysiology of anorexia nervosa (AN). Here, the relationship between the gastrointestinal microbiota and symptoms of depression, anxiety, and eating disorder pathology in patients with AN before (n = 55) and after weight restoration (n = 44) was investigated by reanalyzing the data of the MICROBIAN study. The gastrointestinal microbiota was analyzed using 16S #rRNA amplicon sequencing. Symptoms of anxiety disorder, depression, and the severity of the eating disorder were measured by validated questionnaires. All analyses were adjusted for the body mass index (BMI). Several significant findings between psychological parameters and the gastrointestinal microbiota were not evident after controlling for the BMI. No differences in alpha and beta diversity between groups of higher and lower symptom severity levels for depression and anxiety were found. Positive associations between species of Blautia and Ruminococcus and depression symptoms, and between the phylum Firmicutes and anxiety symptoms were observed after rehabilitation, respectively. A positive correlation was found between propionate and acetate levels and the reduction of depression severity during inpatient treatment. Accounting for the weight status when analyzing the relationship between psychological parameters and the gastrointestinal microbiota in patients with underweight is important since the BMI may be the driver for many observed changes. https://www.mdpi.com/2072-6643/16/6/891?utm_source=dlvr.it&utm_medium=tumblr
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researchers at Washington University School of Medicine in St. Louis have found, in mice, that a strain of gut bacteria—Ruminococcus gnavus—can enhance the effects of cancer immunotherapy.
Gut bacteria enhance cancer immunotherapy in mouse study
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Gut microbiome of patients with PACS were characterised by higher levels of Ruminococcus gnavus, Bacteroides vulgatus and lower levels of Faecalibacterium prausnitzii. Persistent respiratory symptoms were correlated with opportunistic gut pathogens, and neuropsychiatric symptoms and fatigue were correlated with nosocomial gut pathogens, including Clostridium innocuum and Actinomyces naeslundii. Butyrate-producing bacteria, including Bifidobacterium pseudocatenulatum and Faecalibacterium prausnitzii showed the largest inverse correlations with PACS at 6 months.
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