#proteomic

[cbirt]

Scientists at St. Jude Children’s Research Hospital have published their findings on SJ3149, a chemical with broad efficacy against various cancer types, particularly acute myeloid leukemia (AML). Scientists worked together to discover and improve a chemical molecule that functions as a molecular “super-glue” for a variety of tumors. SJ3149 binds to cancer-related protein casein kinase 1 alpha (CK1α), causing its elimination. The findings were published in the journal Nature Communications.

Have you ever wished you could just put a “Do Not Enter” sign on a faulty protein in a cancer cell? Thanks to molecular glue degraders, scientists are coming closer to doing just that. These ingenious tiny molecules function as matchmakers, bringing together a protein designated for destruction (the target) and the cellular executioner (an E3 ligase) in a lethal embrace. As a result, the target protein is tagged and disposed of, providing a fresh approach to cancer treatment.

Molecular glues work by hijacking the cell’s natural protein recycling system. The molecular glue binds the targeted protein to an enzyme, marking it for destruction via proteasomal degradation. For many cancer-related proteins that conventional small molecule inhibitors cannot effectively target, molecular glues may be a feasible therapeutic option. This prompted scientists at St. Jude to create a vast proprietary library of molecular glues and screen it against a variety of cancer cell lines, resulting in an early hit.

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[smokszyvverstar]

Told my professor that i read a bunch of papers and didnt understand anything and he said that it'll probably be at about 10 to 20 papers that things will finally start falling into place. Because im new to that area

And i needed to hear that

I felt stupid because i wasnt understanding high level professional scientific papers in a field that the only thing i knew about it before is "oh yea, it exists"

And maybe you need to hear it too. And maybe Im posting this just so i can finally internalise it.

You wont understand everything the first time you study it. It will take weeks, months, years. And thats ok. Thats normal.

So sit down and allow yourself to reread the same paragraph five times because you dont understand. Thats how learning starts.

And the best thing is, that even after decades, you wont know everything. So its ok to not know everything

[studentbyday]

day 11 // 100dop++

src: coffee shop vibes

The fastest way to kill something special is to compare it to something else. Sometimes it's other people, sometimes it's imagined successful versions of me many years from now and I wonder how I can ever be her with where I am right now and if it's possible at all. But I can't compare their many years of experience to my one. It just wouldn't be fair.

journal and/or meditate ✅ (been feeling anxious about lab stuff and rather annoyed in general, probs bc of not being entirely well rested, so i needed to meditate, i guess, even if it was hard.)

physio ✅

finish watching video on ms-based proteomics ✅

try to read 2nd package article ✅ (barely understood...gotta come back to it later)

slowly work through documentation of 1st package ✅ (still got a long way to go)

I hope the lab will still want me after they find out how little I actually know 🥺 But if not, it's back to studying at my own pace, which isn't that bad either. If I've learned anything in the past 2 days, it's that I really need to brush up on and learn more stats and math and how R plays a role in it, so that's what I'll be focusing on next if I don't get this position...

[everythingaboutbiotech]

Common uses of bioinformatics

💡Sequence analysis Analyzing DNA and protein sequences to identify genes, regulatory regions & mutations.

💡Gene expression Analyzing RNA expression data from experiments like microarrays or RNA-seq to understand gene regulation.

💡Phylogenetics Constructing evolutionary relationships between organisms based on genetic data and genomic comparisons.

💡Molecular modeling Predicting protein structure and docking drugs to proteins using computational modeling and simulation.

💡Databases & Data mining Developing databases like GenBank to store biological data and mining it to find patterns.

💡Genomics Studying entire genomes, including sequencing and assembling genomes as well as identifying genes and genomic variations.

Follow @everythingaboutbiotech for useful posts.

[tenfluenza]

do you ever do something that's so incredibly out of your paygrade

[scientificinquirer-blog]

Large-scale proteomics in population-based studies from UK and Iceland.

In an article revealed today in Nature, scientists  from deCODE Genetics, a subsidiary of the pharmaceutical company Amgen, demonstrated how plasma proteomics can contribute to a better understanding of diseases. The study’s focus on the plasma proteome led the team to find associations between various diseases and the levels of specific proteins. “Measuring a great number of proteins in a…

[aartichede08]

Proteomics Market Size Estimation, Consumption, And Growth Opportunities Till 2028

Proteomics Market research report provides comprehensive information on the market. It also includes in-depth information about Market #Drivers, Opportunities, Market Restraints, Market Growth #Challenges and Cumulative #Growth Analysis. Moreover, the report also provides an in-depth analysis of the Proteomics Market by identifying key players. The report also examines the #competitive landscape of the Proteomics Market industry and analyses its impact on the growth of this market over the next few years. The segmental analysis focuses on revenue and forecast for the period 2019-2029.

Request PDF Sample Copy of Report @ https://www.axiommrc.com/request-for-sample/11462-proteomics-market-report

Proteomics refers to the large scale characterization of the entire protein complement of cells, tissues and even whole organisms. Proteomics is the large-scale study of proteins. Proteins are vital parts of living organisms, with many functions such as the formation of structural fibers of muscle tissue, enzymatic digestion of food, or synthesis and replication of DNA.

The competitive landscape analysis of the Proteomics market is primarily focused on expanding the growth of the Proteomics market with new return type innovation, business expansion, and the increasing presence of a range of manufacturers operating in the reverse logistics market has led to growing demand for the market. 

Market Key Players

Bio-Rad Laboratories, Inc.

Illumina, Inc.

Agilent Technologies, Inc.

Danaher Corporation

General Electric

Thermo Fisher Scientific, Inc.

Bruker Corporation

F. Hoffmann-La Roche Ltd.

Promega Corp.

Merck KGaA

Biognosys AG

Bruker

Caprion Biosciences Inc.

Luminex Corporation

Genzyme Corporation

LI-COR, Inc.

Waters Corporation

To Buy Proteomics Market Report https://www.axiommrc.com/buy_now/11462-proteomics-market-report

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[cbirt]

In a recently published study, Stanford Medicine researchers highlighted age-related problems in humans and showed how aging varies from person to person and between organs within an individual. Researchers used human blood plasma protein levels from particular organs to examine aging in 11 key organs in real people. The approach suggested by the authors offers a straightforward and comprehensible way to research the aging of organs. Understanding the molecular changes in human organs is crucial for addressing the global disease burden and revolutionizing patient care, preventative medicine, and drug development. Current methods present are either expensive or need to provide the required molecular insights. To combat this problem, the researchers hypothesized that complete quantification of organ-specific proteins in plasma could enable minimally invasive assessment and tracking of human aging for any organ.

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[global-research-report]

Exploring Regional Insights in the Proteomics Market: Trends and Predictions

The global proteomics market was valued at USD 24.29 billion in 2023 and is projected to grow at a compound annual growth rate (CAGR) of 13.10% from 2024 to 2030. This robust growth is driven by several key factors, including the rising prevalence of chronic and infectious diseases, the increasing demand for advanced diagnostic solutions for targeted disease treatment, and the growing need for personalized medicine. Additionally, technological advancements in protein analysis are further fueling the market's expansion, providing more precise tools for disease diagnosis and therapy.

Factors Driving Market Growth:

One of the primary drivers of the proteomics market is the increasing prevalence of chronic and infectious diseases worldwide. The World Health Organization (WHO) projects that the number of new cancer cases will rise to over 35 million by 2050, a 77% increase from the approximately 20 million cases anticipated in 2022. This surge in disease prevalence is spurring greater demand for pathogenesis research, as well as the development of advanced diagnostics and therapeutics. For example, a study published in Nature Communications in July 2024 highlighted how proteomics-based techniques were used to identify effectors secreted by Rickettsia spp., advancing our understanding of the host-pathogen interface.

Additionally, proteomics is playing a significant role in aging research. A study published in August 2024 in Nature Medicine introduced a proteomic aging clock, which uses plasma proteins to measure an individual's biological age. This tool can predict the risk of age-related diseases, multimorbidity, and even mortality across different populations. Emerging technologies like top-down proteomics are also enhancing our understanding of how proteoforms—distinct variations of proteins—contribute to disease mechanisms and precision medicine, helping to bridge the gap between genotypes (genetic makeup) and phenotypes (observable traits).

Gather more insights about the market drivers, restrains and growth of the Proteomics Market 

Regional Insights:

The global market for proteomics is experiencing strong growth across all regions, with significant contributions from North America, Europe, and the rapidly expanding Asia Pacific market.

North America:

In 2023, North America dominated the proteomics market, accounting for 45.97% of the total revenue share. This dominance can be attributed to the region’s advanced technological infrastructure, strong demand for disease diagnostics, and extensive research and development (R&D) investments, particularly in the fields of precision medicine and biotechnology. The presence of highly advanced healthcare facilities and substantial government funding for biotechnology and healthcare research further supports market growth in the region.

United States:

The U.S. proteomics market is expected to grow steadily throughout the forecast period, driven by its robust R&D landscape in biotechnology and life sciences. The U.S. is a leader in mass spectrometry technology, which has widespread applications in medicine, biotechnology research, and pharmaceutical development. Additionally, the presence of key players in the industry contributes to ongoing innovations, advancing proteomics research and its application in drug discovery, diagnostics, and personalized medicine.

Europe:

Europe is expected to experience significant growth in the proteomics market from 2024 to 2030, supported by a strong biotechnology R&D sector, an increasing focus on spatial biology research, and the presence of key industry players. Government investments, along with funding from private sources, are facilitating the expansion of proteomics research and driving the commercialization of proteomics products across the region.

United Kingdom:

The UK is poised for notable growth in the proteomics market due to advancements in mass spectrometry and its applications in a variety of fields, including oncology, neurology, immunology, pathology, and personalized medicine. The UK’s strong scientific community and healthcare infrastructure further support the adoption of proteomics technologies.

Germany:

Germany is witnessing substantial growth in the multi-omics field, which integrates proteomics with genomics, metabolomics, and other data types. The country has an active biotechnology and pharmaceutical sector, with strong support from academic institutions and government funding for proteomics-related research. For instance, the European Molecular Biology Laboratory (EMBL) in Germany hosted events in early 2024 focused on the integration and analysis of multiomics data, underscoring the country’s leadership in this area.

France:

In France, the proteomics market is expected to grow due to the increasing adoption of advanced protein analysis technologies in areas like cancer research, drug discovery, and translational research. Government funding and investments in biotechnology further support the market’s growth, positioning France as a key player in the European proteomics landscape.

Asia Pacific:

The Asia Pacific region is forecast to grow at the fastest CAGR of 15.97% from 2024 to 2030. Several factors contribute to this rapid growth, including the rising prevalence of chronic diseases, an increasing preference for outsourcing proteomics-based projects, and robust public and private funding for proteomics R&D. Additionally, favorable government regulations and the strong presence of biotechnology and biopharmaceutical companies in the region are driving market expansion.

Japan:

Japan’s proteomics market is expected to grow at a significant rate due to the country’s substantial investments in drug discovery and development, technological advancements, and the increasing focus on personalized medicine. Government policies supporting biotechnology innovation also contribute to market growth in Japan.

China:

China’s proteomics market is poised for growth, driven by the country’s focus on advancing biotechnology and therapeutics. The increasing demand for precision medicine, coupled with rising awareness of chronic diseases and the need for more effective diagnostic tools, is fueling the market’s expansion. Additionally, government investments in healthcare innovation and research are further propelling growth.

India:

India is expected to witness rapid growth in its proteomics market due to the increasing use of proteomics-based research and the growing presence of biopharmaceutical companies involved in drug discovery. Government investments in scientific research and healthcare innovation further boost the market’s expansion in the country.

Middle East and Africa:

The Middle East and Africa (MEA) region is expected to see growth in the proteomics market due to increasing demand for improved diagnostics that aid in the prevention and treatment of diseases, alongside rising government funding in biotechnology research. The region’s healthcare infrastructure development and focus on biotech innovation support market growth.

Saudi Arabia:

In Saudi Arabia, the proteomics market is expected to grow due to significant investments in biotechnology, increased research activities, and government initiatives aimed at advancing scientific research and innovation in health sciences.

Kuwait:

The proteomics market in Kuwait is anticipated to grow as the country engages in global collaborations with researchers and biotech companies. These partnerships facilitate the exchange of knowledge and access to advanced technologies, helping boost the market in Kuwait.

Browse through Grand View Research's Category Biotechnology Industry Research Reports.

The Latin America molecular methods market for food safety testing size was valued at USD 154.6 million in 2024 and is projected to grow at a CAGR of 10.0% from 2025 to 2030.

The global plasma fractionation market sizewas estimated at USD 35.8 billion in 2024 and is projected to grow at a CAGR of 8.5% from 2025 to 2030.

Key Proteomics Companies:

The following are the leading companies in the proteomics market. These companies collectively hold the largest market share and dictate industry trends.

Illumina, Inc.

Agilent Technologies, Inc.

Bio-Rad Laboratories, Inc.

Thermo Fisher Scientific, Inc.

Bruker Corporation

F. Hoffmann-La Roche Ltd.

Waters Corporation

Merck KGaA

Danaher

Standard BioTools Inc.

Order a free sample PDF of the Market Intelligence Study, published by Grand View Research.

[hellsiteproteomics]

Amino acid sequence:

NGL I I WAS AN ELEPHANT ID WHIP THAT THING ARND CRAY STYLE

Closest match:

ParB N-terminal domain-containing protein [Patescibacteria group bacterium]

Common name:

Patescibacteria

(image source)

ngl if i was a elphephant id whip that thing around crazy style

[market-insider]

Proteomics Market Forecast: Technological Advancements Shaping the Future

The global proteomics market size is expected to reach USD 58.16 billion by 2030, registering a CAGR of 13.10% from 2024 to 2030, according to a new report by Grand View Research, Inc. The major factors driving theindustry growth are a rise in the demand for personalized medicine, an expansion of the pipeline of diagnostics utilizing proteomics mass spectrometry as well as biochip platforms, and discoveries based on genomics. Moreover, owing to the importance of proteomics in drug development, numerous pharmaceutical companies have established their own proteomic divisions, which are fueling the expansion of the global industry. For instance, in September 2021, Biognosys, announced the collaboration with Evotec, to promote the use of next-generation proteomics in clinical research and drug discovery.

The COVID-19 outbreak is expected to have a significant impact on the industry, as researchers across the world are concentrating on decoding 3D structures of SARS-CoV-2 proteins. To create effective medications and biological products against COVID-19, scientists are also attempting to examine the identification techniques, structures, characterization, and interactions of these proteins. The protein structure of virus proteins and their specific locations must be understood to find a novel, efficient target treatment medication for a virus. Therefore, it will increase the demand for drug development for COVID-19 and propel industry growth. The growing need for customized medications increased R&D spending, and technological developments related to proteomics components are also driving the market.

In addition, attractive market expansion potential for proteomics is anticipated to come from improvements in mass spectrometry-based proteomics and lucrative opportunities related to biomarker identification. Thereby, propelling the market growth.The introduction of new and improved proteomics techniques by major industry participants is projected to further accelerate the growth of the industry. For instance, to provide quick data acquisition for shotgun proteomics, Bruker Corp. introduced the timsTOF Pro system for Parallel Accumulation And Serial Fragmentation (PASEF) mass spectrometry in September 2017. This system uses proprietary Trapped Ion Mobility Spectrometry (TIMS) technology.Furthermore, proteomic research advancements have accelerated the detection of protein biomarkers, protein biochips & pharmacoproteomics, and proteomics-based molecular diagnostics, which have all made significant contributions to the development of personalized medicine.

For More Details or Sample Copy please visit link @: Proteomics Market Report

Proteomics Market Report Highlights

The reagent & consumables product segment held the largest share in 2023 due to rising research activities and the growing demand for protein separation from complicated mixtures for efficient analysis

The clinical diagnostics application segment held a larger share in 2023 due to the development of sophisticated & specialized tests for early disease detection and disease management

The spectroscopy technology segment held the maximum share in 2023 owing to the increasing usage in toxicological response profiling, basic molecular biology, biomarker identification, and pharmaceutical target screening

North America led the global industry in 2023 due to a rise in demand for personalized drugs, the existence of major players operating in the U.S. and a highly developed healthcare research framework, and substantial expenditure on R&D

Asia Pacific is expected to grow at the highest CAGR over the projected period due to factors, such as the rising prevalence of target diseases, increasing aging population, and rising proteomics adoption

Gain deeper insights on the market and receive your free copy with TOC now @: Proteomics Market Report

We have segmented the global proteomics market based on Product & services, application, technology, region.

[alishaaishu]