#proteomic

[cbirt]

Scientists at St. Jude Children’s Research Hospital have published their findings on SJ3149, a chemical with broad efficacy against various cancer types, particularly acute myeloid leukemia (AML). Scientists worked together to discover and improve a chemical molecule that functions as a molecular “super-glue” for a variety of tumors. SJ3149 binds to cancer-related protein casein kinase 1 alpha (CK1α), causing its elimination. The findings were published in the journal Nature Communications.

Have you ever wished you could just put a “Do Not Enter” sign on a faulty protein in a cancer cell? Thanks to molecular glue degraders, scientists are coming closer to doing just that. These ingenious tiny molecules function as matchmakers, bringing together a protein designated for destruction (the target) and the cellular executioner (an E3 ligase) in a lethal embrace. As a result, the target protein is tagged and disposed of, providing a fresh approach to cancer treatment.

Molecular glues work by hijacking the cell’s natural protein recycling system. The molecular glue binds the targeted protein to an enzyme, marking it for destruction via proteasomal degradation. For many cancer-related proteins that conventional small molecule inhibitors cannot effectively target, molecular glues may be a feasible therapeutic option. This prompted scientists at St. Jude to create a vast proprietary library of molecular glues and screen it against a variety of cancer cell lines, resulting in an early hit.

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[smokszyvverstar]

Told my professor that i read a bunch of papers and didnt understand anything and he said that it'll probably be at about 10 to 20 papers that things will finally start falling into place. Because im new to that area

And i needed to hear that

I felt stupid because i wasnt understanding high level professional scientific papers in a field that the only thing i knew about it before is "oh yea, it exists"

And maybe you need to hear it too. And maybe Im posting this just so i can finally internalise it.

You wont understand everything the first time you study it. It will take weeks, months, years. And thats ok. Thats normal.

So sit down and allow yourself to reread the same paragraph five times because you dont understand. Thats how learning starts.

And the best thing is, that even after decades, you wont know everything. So its ok to not know everything

[studentbyday]

day 11 // 100dop++

src: coffee shop vibes

The fastest way to kill something special is to compare it to something else. Sometimes it's other people, sometimes it's imagined successful versions of me many years from now and I wonder how I can ever be her with where I am right now and if it's possible at all. But I can't compare their many years of experience to my one. It just wouldn't be fair.

journal and/or meditate ✅ (been feeling anxious about lab stuff and rather annoyed in general, probs bc of not being entirely well rested, so i needed to meditate, i guess, even if it was hard.)

physio ✅

finish watching video on ms-based proteomics ✅

try to read 2nd package article ✅ (barely understood...gotta come back to it later)

slowly work through documentation of 1st package ✅ (still got a long way to go)

I hope the lab will still want me after they find out how little I actually know 🥺 But if not, it's back to studying at my own pace, which isn't that bad either. If I've learned anything in the past 2 days, it's that I really need to brush up on and learn more stats and math and how R plays a role in it, so that's what I'll be focusing on next if I don't get this position...

[everythingaboutbiotech]

Common uses of bioinformatics

💡Sequence analysis Analyzing DNA and protein sequences to identify genes, regulatory regions & mutations.

💡Gene expression Analyzing RNA expression data from experiments like microarrays or RNA-seq to understand gene regulation.

💡Phylogenetics Constructing evolutionary relationships between organisms based on genetic data and genomic comparisons.

💡Molecular modeling Predicting protein structure and docking drugs to proteins using computational modeling and simulation.

💡Databases & Data mining Developing databases like GenBank to store biological data and mining it to find patterns.

💡Genomics Studying entire genomes, including sequencing and assembling genomes as well as identifying genes and genomic variations.

Follow @everythingaboutbiotech for useful posts.

[tenfluenza]

do you ever do something that's so incredibly out of your paygrade

[scientificinquirer-blog]

Large-scale proteomics in population-based studies from UK and Iceland.

In an article revealed today in Nature, scientists  from deCODE Genetics, a subsidiary of the pharmaceutical company Amgen, demonstrated how plasma proteomics can contribute to a better understanding of diseases. The study’s focus on the plasma proteome led the team to find associations between various diseases and the levels of specific proteins. “Measuring a great number of proteins in a…

[aartichede08]

Proteomics Market Size Estimation, Consumption, And Growth Opportunities Till 2028

Proteomics Market research report provides comprehensive information on the market. It also includes in-depth information about Market #Drivers, Opportunities, Market Restraints, Market Growth #Challenges and Cumulative #Growth Analysis. Moreover, the report also provides an in-depth analysis of the Proteomics Market by identifying key players. The report also examines the #competitive landscape of the Proteomics Market industry and analyses its impact on the growth of this market over the next few years. The segmental analysis focuses on revenue and forecast for the period 2019-2029.

Request PDF Sample Copy of Report @ https://www.axiommrc.com/request-for-sample/11462-proteomics-market-report

Proteomics refers to the large scale characterization of the entire protein complement of cells, tissues and even whole organisms. Proteomics is the large-scale study of proteins. Proteins are vital parts of living organisms, with many functions such as the formation of structural fibers of muscle tissue, enzymatic digestion of food, or synthesis and replication of DNA.

The competitive landscape analysis of the Proteomics market is primarily focused on expanding the growth of the Proteomics market with new return type innovation, business expansion, and the increasing presence of a range of manufacturers operating in the reverse logistics market has led to growing demand for the market. 

Market Key Players

Bio-Rad Laboratories, Inc.

Illumina, Inc.

Agilent Technologies, Inc.

Danaher Corporation

General Electric

Thermo Fisher Scientific, Inc.

Bruker Corporation

F. Hoffmann-La Roche Ltd.

Promega Corp.

Merck KGaA

Biognosys AG

Bruker

Caprion Biosciences Inc.

Luminex Corporation

Genzyme Corporation

LI-COR, Inc.

Waters Corporation

To Buy Proteomics Market Report https://www.axiommrc.com/buy_now/11462-proteomics-market-report

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[cbirt]

In a recently published study, Stanford Medicine researchers highlighted age-related problems in humans and showed how aging varies from person to person and between organs within an individual. Researchers used human blood plasma protein levels from particular organs to examine aging in 11 key organs in real people. The approach suggested by the authors offers a straightforward and comprehensible way to research the aging of organs. Understanding the molecular changes in human organs is crucial for addressing the global disease burden and revolutionizing patient care, preventative medicine, and drug development. Current methods present are either expensive or need to provide the required molecular insights. To combat this problem, the researchers hypothesized that complete quantification of organ-specific proteins in plasma could enable minimally invasive assessment and tracking of human aging for any organ.

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[market-insider]

Proteomics Market Forecast: Technological Advancements Shaping the Future

The global proteomics market size is expected to reach USD 58.16 billion by 2030, registering a CAGR of 13.10% from 2024 to 2030, according to a new report by Grand View Research, Inc. The major factors driving theindustry growth are a rise in the demand for personalized medicine, an expansion of the pipeline of diagnostics utilizing proteomics mass spectrometry as well as biochip platforms, and discoveries based on genomics. Moreover, owing to the importance of proteomics in drug development, numerous pharmaceutical companies have established their own proteomic divisions, which are fueling the expansion of the global industry. For instance, in September 2021, Biognosys, announced the collaboration with Evotec, to promote the use of next-generation proteomics in clinical research and drug discovery.

The COVID-19 outbreak is expected to have a significant impact on the industry, as researchers across the world are concentrating on decoding 3D structures of SARS-CoV-2 proteins. To create effective medications and biological products against COVID-19, scientists are also attempting to examine the identification techniques, structures, characterization, and interactions of these proteins. The protein structure of virus proteins and their specific locations must be understood to find a novel, efficient target treatment medication for a virus. Therefore, it will increase the demand for drug development for COVID-19 and propel industry growth. The growing need for customized medications increased R&D spending, and technological developments related to proteomics components are also driving the market.

In addition, attractive market expansion potential for proteomics is anticipated to come from improvements in mass spectrometry-based proteomics and lucrative opportunities related to biomarker identification. Thereby, propelling the market growth.The introduction of new and improved proteomics techniques by major industry participants is projected to further accelerate the growth of the industry. For instance, to provide quick data acquisition for shotgun proteomics, Bruker Corp. introduced the timsTOF Pro system for Parallel Accumulation And Serial Fragmentation (PASEF) mass spectrometry in September 2017. This system uses proprietary Trapped Ion Mobility Spectrometry (TIMS) technology.Furthermore, proteomic research advancements have accelerated the detection of protein biomarkers, protein biochips & pharmacoproteomics, and proteomics-based molecular diagnostics, which have all made significant contributions to the development of personalized medicine.

For More Details or Sample Copy please visit link @: Proteomics Market Report

Proteomics Market Report Highlights

The reagent & consumables product segment held the largest share in 2023 due to rising research activities and the growing demand for protein separation from complicated mixtures for efficient analysis

The clinical diagnostics application segment held a larger share in 2023 due to the development of sophisticated & specialized tests for early disease detection and disease management

The spectroscopy technology segment held the maximum share in 2023 owing to the increasing usage in toxicological response profiling, basic molecular biology, biomarker identification, and pharmaceutical target screening

North America led the global industry in 2023 due to a rise in demand for personalized drugs, the existence of major players operating in the U.S. and a highly developed healthcare research framework, and substantial expenditure on R&D

Asia Pacific is expected to grow at the highest CAGR over the projected period due to factors, such as the rising prevalence of target diseases, increasing aging population, and rising proteomics adoption

Gain deeper insights on the market and receive your free copy with TOC now @: Proteomics Market Report

We have segmented the global proteomics market based on Product & services, application, technology, region.

[hellsiteproteomics]

Amino acid sequence:

NGL I I WAS AN ELEPHANT ID WHIP THAT THING ARND CRAY STYLE

Closest match:

ParB N-terminal domain-containing protein [Patescibacteria group bacterium]

Common name:

Patescibacteria

(image source)

ngl if i was a elphephant id whip that thing around crazy style

[alishaaishu]

[researchinsights]

The global proteomic biomarker analytics market size was valued at USD 24,983.8 million in 2023 and is poised to grow at a significant CAGR of 9.1% during the forecast period 2024-30. It also includes market size and projection estimations for each of the five major regions from 2024 to 2030. The research report includes historical data, trending features, and market growth estimates for the future. Furthermore, the study includes a global and regional estimation and is further split by nations and categories within each region.

[health-views-updates]

Proteomics Market Outlook: Trends, Challenges, and Opportunities

Proteomics Market Outlook, Scope & Overview:

Industry reports indicate that the global proteomics market was valued at USD 25.3 billion in 2022 and is projected to reach USD 70.8 billion by 2030, growing at a CAGR of 13.7% over the forecast period 2023-2030.

Technological Advancements to Drive Growth of Global Proteomics Market

The adoption of advanced proteomics technologies will continue to influence global market revenues. Researchers and healthcare providers are increasingly utilizing proteomics for drug discovery, biomarker identification, and personalized medicine, thereby driving the market growth.

As a product segment, mass spectrometry currently holds a significant share of the global proteomics market. This segment is anticipated to grow at a year-over-year rate of 13.7% in 2023 over 2022 and reach USD 70.8 billion in revenues by 2030. The increasing need for high-throughput protein analysis and advancements in mass spectrometry technologies are expected to drive market growth.

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Proteomics Solutions – Market Dynamics

Drivers:

Proteomics solutions are witnessing significant growth in the global market due to their ability to provide comprehensive insights into protein functions, interactions, and structures. The increasing adoption of proteomics in drug development, disease diagnosis, and personalized medicine are key factors driving the adoption of proteomics solutions worldwide. Additionally, the rising prevalence of chronic diseases and the growing emphasis on precision medicine are further propelling market growth.

Restraints:

Despite the growth potential, challenges such as high costs associated with proteomics research, complexity of data analysis, and the need for skilled professionals are hindering the widespread adoption of proteomics solutions. Moreover, concerns about reproducibility and standardization in proteomics research pose additional challenges to market expansion.

Proteomics Solutions – Market Outlook

The proven benefits of proteomics solutions in advancing biomedical research, improving disease understanding, and facilitating drug development have contributed to the market's growth. Proteomics solutions are expected to witness increased adoption across major markets, including North America, Europe, and Asia Pacific, driven by technological advancements and the increasing focus on personalized healthcare.

Global Proteomics Market

The rise in demand for proteomics solutions in developed and emerging markets is expected to drive market growth over the forecast period. North America currently holds a significant market share in the global proteomics market, with the US being a key contributor to market revenues. Europe and Asia Pacific regions are also experiencing rapid adoption of proteomics solutions, supported by favorable regulatory frameworks and increasing investments in healthcare research.

Key Players in the Proteomics Solutions Market

Leading companies in the proteomics solutions market include Thermo Fisher Scientific, Agilent Technologies, Danaher Corporation, and Waters Corporation. These companies are at the forefront of developing and commercializing advanced proteomics platforms for various applications, including biomarker discovery, drug development, and clinical diagnostics.

In conclusion, the global proteomics market is poised for substantial growth over the forecast period, driven by technological advancements, increasing healthcare expenditures, and the expanding adoption of proteomics in biomedical research and clinical practice.

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