#polycythemia vera

[scrillpy]

this is gonna be out of place for my blog but i'm a trans masc 3 years on T and last week i got diagnosed with the very early stages of polycythemia vera and just. i wanted to ask if stopping HRT will make it stop? i understand there's no cure but would stopping T make it stop progressing perhaps?

it may be a silly question but i'm just learning about it now and i think tumblr is a good place for getting answers for things like this

[hopefuldesolate]

hi gang i might have PV/leukemia ☹️ so that sucks for me. its not that serious bcuz im still young but if i have to get a bone marrow sample ill scream.

[timesofpharma]

Polycythemia Vera

Polycythemia Vera (PA)/ Erythrocytosis: What is Polycythemia Vera? Why uncontrolled red blood cells are produced in polycythemia Vera? Polycythemia Vera is a blood disorder, where in the red blood cells formation is abnormally higher. Polycythemia Vera is a rare blood cancer, It is caused due to mutation in the gene Janus kinase-2 (JAK2), due to which a neoplastic growth of hematopoietic…

[simplykaren]

Today in my search history:

polycythemia vera

difference between blush and flush

what does fluid in the lungs sound like

the chronicles of narnia

what temperature does asphalt burn at

what temperature does concrete burn at

fire color and temperature

converting Fahrenheit to Celsius

[oncozine]

 In this episode of The Onco'Zine Brief, Peter Hofland talks with two experts about their research and the impact the outcomes from these studies may have on the treatment of patients diagnosed with cancer. First, Hofland talks with Christopher Heery, MD. Dr Heery is a board-certified medical oncologist with primary expertise in the translational and clinical development of immunotherapies, including, but not limited to PD-L1 inhibitors, therapeutic cancer vaccines, immune suppressor modulator, adoptive NK cells, and other therapeutics. As the chief medical officer at Arcellx, he is responsible for medical oversight, clinical strategy, medical affairs, and regulatory strategy for the company’s pipeline of novel – investigational drug. In the second half of the program, Hofland talks with Srdan Verstovsek, Dr Srdan Verstovsek, MD, PhD., a Medical Oncologist and Professor in the Department of Leukemia at The University of Texas MD Anderson Cancer Center, about some of the developments in the treatment of myeloproliferative neoplasm, which are types of blood cancer that begin with an abnormal mutation or change, in a stem cell in the bone marrow. These change leads to an overproduction of any combination of white cells, red blood cells and platelets – and results in a number of diseases, including:

Essential Thrombocythemia (ET) Is a rare blood disease in which the bone marrow produces too many platelets;

Myelofibrosis, a rare disorder in which abnormal blood cells and fibers build up in the bone marrow;

Polycythemia Vera (PV) – a disease in which too many red blood cells are made in the bone marrow and, in many cases, the numbers of white blood cells and platelets are also elevated.

About The Onco'Zine Brief The Onco'Zine Brief is distributed in the United States via PRX (Public Radio Exchange). In the United Kingdom and Europe, the program is distributed via UK Health Radio (UKHR). And the program can be downloaded via most podcasts and streaming media services, including iTunes, Spotify, TuneIn, and iHeart Radio. For more information about The Onco'Zine Brief or how to sponsor or support this public radio broadcast and podcast, visit to download our Media Kit, visit Patreon at or contact the sales team. For more information about cancer and cancer treatments, visit our online journal Onco'Zine. To sign up for The Onco'Zine Newsletter (open for residents of the United States only), text the word CANCER to 66866. The Onco’Zine Brief is made possible, in part, by Java Original Coffee – the home of artisan roasted coffee.

[two-calicos-in-a-trenchcoat]

So

Is there like

Some bad information about cast iron pans going around or what

Like I cant find anything so im gonna say no but my friends mom texted her a little bit ago telling her to stop using cast iron immediately and let her know if she needs new pans

And like my friend has a lot of health problems and her mom has been pushing "cures" and "treatments" on her her whole life so this is probably just more of the same

But the only potential negative i could find to using cast iron pans is that they add iron to whatever you're cooking and if youre at risk for iron overload that could cause problems

But my friend has low iron. So that's not a problem.

And the only negative story I could find involving cast irons pans in the news is that someone got their head bashed in with a cast iron pan a few weeks ago

So we're not really sure where the sudden urgency to get rid of cast iron pans is coming from

[canisalbus]

What?? Why on Earth would they bloodlet Machete when he's already anemic?

Anemia wasn't discovered until 1852, so his physicians have no idea. He's just moody and achy and visibly unwell and bloodletting happens to be the cure-for-all fix at the time.

I don't think I'm exaggerating when I say it was one of the most used treatments in western medicine from ancient Greece to 19th century (and even earlier than that in Egypt, for example). There weren't many ailments that a little bit of breathing a vein wouldn't alleviate, supposedly. This whole concept is based on humoral theory which is a fascinating cornerstone of medical history and also completely unfounded nonsense, look it up if you haven't, it's interesting. People believed that blood didn't circulate through the body, it was created, used up and then the bad blood would stagnate in the extremities. Having too much blood would disturb your humoral balance and create illnesses so removing it was beneficial to your wellbeing. Even completely healthy people would sometimes go get themselves bled a bit just to be sure.

You kind of need blood for your body to function so this treatment was completely pointless at best and life threatening at worst. If you were sick to begin with it would only weaken you further (and expose you to potential infections, which in the absence of antibiotics, wasn't great). The only viable use for it would have to be rare blood disorders where your body produces too many red blood cells, like polycythemia vera, essentially the polar opposite of anemia.

[mariamakeslemons]

Spooktober 2024: Day 2 Vampire

Warning: Medical inaccuracy, inaccurate depiction of DID (purposeful for story purposes only)

Nikto blinks slowly, feeling so fucking tired. Before, in a barely recalled memory, he’d put on the mask of acceptability and would head to a club or bar. He’d seduce someone and drink enough to make them woozy, like they were drunk, before plopping them in a taxi and finding one or two more to repeat. Until he was full. Now, they can’t seduce anyone. Too much, too many, too feral. Too, too, too. Nikto can’t even think of him, but of them. What once was, the man. The monster, all too ready to rip and tear anything that comes too close. The stray mutt, looking for a home but too scared to accept the hands that reach out.

“Excuse me?” you say, pulling Nikto out of the musing of each self. Blue eyes look up at you from the dark mask, watching as you furrow your brow. You ask, “Are you okay? You seem off.” Nikto blinks slowly, pushing through the voices to answer you, the nurse, the medic, the pretty one. He finally gives a single nod, which only makes you frown deeply. Crouching before him, you look into his eyes and he knows. Oh, a little seer, a little psychic, a sweet little one that knows.

“Shit,” you hiss, standing up and striding quickly to the refrigerator that is held in the medical room. Nikto sits and watches as you look through the chill to pull out a blood bag.

“Honestly,” you complain, “Please tell us if you are not human. There’s enough others that need blood for us to have spare blood bags.” Nikto blinks down at the blood bag, before raising his eyes back to you as you turn to a clipboard and write something down before pausing.

“Do you want to mention what you are, or just that you need blood?” you ask.

“Why?” Nikto finally speaks, tilting his head at your question.

“Why do I ask or why does anything need to be noted?” you ask back. Nikto pauses, mulling over the question.

“Both,” he decides.

“I ask because most of your coworkers want as little written about them as possible,” you explain, “And I want to write something down so we don’t starve you.” Nikto blinks again, mulling over the options given.

“We need blood,” he decides to declare. You nod once and write down something on the clipboard before grabbing the fabric that drapes around the medbed he’s sitting on.

“I can’t let you leave with the blood bag, but I know you’re one of mercs who doesn’t show your face,” you start, giving him a smile, “So, I’ll close the curtain and let you drink the blood, you let me know when you finish so we can set up a timetable for your feedings afterward.” Nikto blinks once before nodding once. Your smile glows before he’s swallowed by darkness as you draw the curtain. Looking down at the blood bag, Nikto decides that you are his, theirs, ours.

----------------------------------------------------------------------------

The next time Nikto arrives to the medical bay while you are there, he finds out where the blood bags come from. You sit on the bed, sipping at a water as an IV fills with your precious, delicate, delectable blood.

“Seriously,” one of the other medics joke, no one noticing Nikto hide in the shadows, “If it wasn’t for your polycythemia vera, we’d have more trouble keeping up with the demand for blood.” You don’t reply verbally, as your puffed out cheeks show that you have a mouthful of water. But the way you unwrap your middle finger from the bottle is telling enough. Nikto feels the man lean forward, very interested as your colleagues laugh good naturedly at your gesture. The monster wants to rip the IV from your arm and drink from the source, your comfort be damned. The mutt wants to curl against you and whisper how one of your coworkers can be taken down with a swift kick to their left knee.

“I’m just glad I only need to do this once a week,” you sigh after swallowing the water, leaning back on the bed. There’s more laughter and Nikto itches for one more. One from you specifically. So, he steps forward purposefully, startling your coworkers. You, however, only turn your head curiously before your pretty, bright, lovely smile appears.

“Hello Nikto,” you greet easily. He preens at your greeting, giving you a nod before settling on the same bed you are laying on. Your eyebrows raise and your smile shifts into something amused.

“Are you tired?” you ask, looking into his eyes. He knows that you know he isn’t, but he still shakes his head. You hum, tilting your head, “Then why are you laying down?”

“Tired,” he says, despite just denying it. The lie is acceptable as you lean your head back and laugh, so pretty, gorgeous, beautiful. Nikto tongues at his canine teeth, feeling them elongate in longing, wanting to leave his bites, his marks, their claims all over your throat and shoulders. Instead, he shuffles closer, cautious to not touch you but longing for it. You don’t seem to mind, having turned to your coworkers and started talking to them about some work Nikto doesn’t care about. He hesitantly leans against you, shuddering at the feeling of your warmth and mouth watering at the scent of your blood. Such a sweet treasure, a pretty thing, a lovely beauty. All for him, Nikto decides now, all for them.

[cruelfeline]

At session about fun emergency cases -> case about polycythemia vera in a cat -> speaker talks about using leeches for therapeutic bloodletting and wound healing -> my evil little ears perk up -> now on leeches.com searching for a pet leech

^--- this is how my mind works

[aileuromania]

TW: blood, cancer

My diagnosis was confirmed today. I have Polycythemia Vera - a type of blood cancer that means that I produce too many red blood cells. It’s also affected my platelet count too, so I’m a clotting mess.

It’s caused by a mutated gene that the haematologist estimates mutated about 6 months ago. They don’t know why it mutated or what caused it to mutate, only that it has.

This is going to be a permanent friend.

My treatment paths are either regular bloodletting, or permanent (“mild”) oral chemotherapy in the form of hydroxyurea. I’m going with the bloodletting for now even though it’s probably going to leave me back in anaemia land. Better that than pretty much guaranteed leukaemia or worse in 15-20 years, but I’ll probably have to move to it. I’m under no illusions here.

There are other treatments down in the US, but they don’t seem to be an option here.

Oh well, at least I know what I’m dealing with now.

[wiredaughter]

Outbreak

××

allison cameron×robert chase ☆ zombie apocalypse ☆ 1008 words ☆ ao3

@augustwritingchallenge day 4: zombie apocalypse @aug-kissed week 1: blow a kiss

Doctor Allison Cameron squints at the whiteboard in House's office. Extending ecchymosis, low grade fever, rash. It doesn't entirely seem like a case but House is, if to be believed, consulting with the federal government; which makes it a case. Of course, he's not around to explain why the patient is at PPTH instead of some blacksite if that's the truth. She exits the room, it's not her job to know why anymore.

The ER pulls her from her job trajectory considerations easily, there seems to have been a highway wreck involving at least six vehicles and she spends the morning up to her elbows on life altering injuries and advanced life support. She doesn't think about the diagnostics team again until she chats with Foreman in the lift to the cafeteria and learns the patient went after a phlebotomist with teeth and nails, making House wonder whether they should add aggressiveness to the list or the patient is just a bit of a prick.

She thinks about it, vaguely, during her lunch with Chase but ultimately doesn't bring it up until they're walking back to their respective stations. Good choice too, going by his general disinterest in the matter.

‘It's irregular, is all, to have the patient here, don't you think?

There's resignation mixed with admiration in the look her boyfriend gives her, and a hint of selfdeprecation in his smile. ‘How is a government consult meant to compel me more than a gun to his head, again?’

Cameron shrugs, stops to kiss him quickly. ‘It just seemed interesting. I’ll see you later.’

As she walks away, she turns in time to see him blowing her a kiss. Yes, her life's changed ever since resigning from the diagnostics department and it hasn't always been easy, but she's excited to let someone in again. Doesn't mean everything's got to change, she thinks, back in House’s office, this time with most of the team assembled. There's more symptoms now, hyperpyrexia, necrosis, erythrocytosis, battle sign. Transmissible = BITES is underlined several times. They've quarantined the floor the patient is being held in, and have anyone who's been in direct contact with him in isolation.

‘Polycythemia vera,’ she suggests, more to get the ball rolling than as a real answer, being that she hasn't seen the patient at all.

‘No hypertension,’ Kutner objects. ‘It's dropping steadily, actually.’

‘How's his spleen?’

‘We're waiting on the test, but palpation suggested no abnormalities.’

‘How about a different neoplasm. Essential thrombocythaemia?’ Thirteen checks the file. ‘Plateletes were high too.’

‘It could fit, but there's no cyanosis…’

She trails off when House looks ready to rule on it, but the door opens before he can, to reveal a harassed looking Chase, still on OR scrubs holding his pager up. ‘You can't page me, House, you're not my boss.’

Instead of answering, House raises a brow as he feels for something on his desk. On cue, Chase's pager goes off. Cameron exchanges a look with Foreman, who looks ready to go back to the differential. Following their cue, Chase looks at the board, almost involuntarily, frowns at what's written there. ‘If you have to page me, can it be for something other than Resident Evil roleplay?’

‘That's your diagnosis?’ House sounds exasperated. ‘Our patient is a zombie?’

‘It's how it always starts, the outbreak. Fever, necrosis, head trauma… Biting.’

‘Thank you, for illustrating exactly why I fired you.’

Chase gives Cameron a look that questions her willingness to listen to this before setting his pager down on House's desk and making for the door. Later, she mouths, and he gives a short nod before exiting. He's back before anyone can comment, wide eyed oh shit expression replacing his previous eyeroll in progress. ‘Tell me Taub is in on the joke?’

‘He went in for an NCV, I told you there's no jo-'

House's words get drowned by gunfire. Cameron moves to where Chase stands, pulling him out of the most direct line from the door to House, guessing whatever this is it's probably House-related. Again. The uniformed men that barge in after a blood splattered Taub don't shoot at anyone, though. The leader pulls down his mask.

‘Doctor House?’ It's not really a question, as he continues speaking directly at him without giving him the chance to direct his attention anywhere else. ‘Your assistance is required on site now, until the situation is handled. This your team?’

House nods, eyes burning holes through Chase’s head like he's jinxed him somehow. The man, who still hasn't introduced himself, talks into his comm to coordinate an extraction as his men exit. Cameron takes the chance to peek out the door, to see twitching, bloodied bodies strewn across the floor. She steps back, horrified, to take Chase's hand. The words zombie outbreak play on her head in his voice.

‘So,’ House leans forward on his cane, holding Chase’s pager up looking entirely too satisfied for someone who just dismissed what seems to be the working theory. ‘In the team, or out?'

Chase squeezes her hand, gives House an unimpressed look and snatches it back. ‘Unless you know someone else with over sixty hours in Deadly Silence, in.’

‘I have 100% completion in Deadly Silence’ Cameron lets her calf slide against Chase's in the chopper after an incredibly short briefing by phone, her words made private by the noise around them.

‘Your government is actually bioengineering zombies and your move is proving my expendability?’ He holds his chest in an exaggerated fashion, pressing their knees together.

‘Competition breeds progress.’ Her tone is too affectionate for her words to have any meaning.

Chase leans in, like he's going to kiss her but thinks better of it, considering their surroundings and the ongoing ‘situation’ that spans half the continental states if the information hasn't changed since they took off. Instead, he settles for an air-kiss. Not her, not now. She pulls him by his improbable tie, locking their lips for what might be the last time if the zombies are really at the gates.

[mcatmemoranda]

Screening evaluation includes CBC/differential, blood smear, history and physical examination, and ferritin, as described in UpToDate content on evaluation of thrombocytosis. Clinical emergencies and complications (eg, thrombosis, bleeding) should be managed without delay by evaluation of thrombocytosis.

CBC: complete blood count; MPN: myeloproliferative neoplasm.* Definitions:

Worrisome findings on smear: Leukemic blasts, leukoerythroblastosis

Persistent thrombocytosis: Platelets >450,000/microL confirmed on repeat CBC

Vasomotor symptoms: Erythromelalgia, flushing, pruritus

Constitutional symptoms: Fever, sweats, weight loss

Unusual thrombotic presentations (eg, unusual or multiple sites; <45 years old; unexplained, unprovoked, or recurrent thrombosis)

¶ Refer to UpToDate content on evaluation of thrombocytosis for details.Δ Refer to UpToDate content on diagnostic testing for MPNs for details.

Thrombocytosis – Thrombocytosis is defined as a platelet count >450,000/microL (>450 x 109/L) in adults and children.

●Causes – Thrombocytosis can be caused by:

•Reactive processes – Platelet counts increase with iron deficiency, splenectomy, and in response to infectious, inflammatory, or malignant conditions.

•Autonomous processes – Essential thrombocythemia, polycythemia vera, and other myeloproliferative neoplasms cause unregulated, clonal proliferation of hematopoietic stem and progenitor cells.

●Evaluation – Initial evaluation (algorithm 1) should seek to distinguish reactive thrombocytosis from an autonomous process, based upon:

•Clinical – History of bleeding, thrombosis, vasomotor symptoms (eg, erythromelalgia [painful feet with redness due to clots], flushing, pruritus), constitutional symptoms (e.g., unexplained fever, sweats, or weight loss), iron deficiency anemia, and examination for splenomegaly

•Laboratory

-Complete blood count (CBC)

-Blood smear

-Serum ferritin

●Further evaluation and management – Further studies and management are guided by findings from the initial evaluation.

Scenarios include:

•Evidence of iron deficiency – Thrombocytosis may be due to iron deficiency in patients with a history of blood loss (eg, gastrointestinal bleeding, menorrhagia, multiple pregnancies), hypochromic/microcytic anemia, or low serum ferritin (eg, <15 ng/mL).

The source of blood loss should be investigated, and the platelet count should be re-evaluated after iron repletion.

•Inflammatory causes – The patient with an apparent infectious or other inflammatory cause of thrombocytosis should be evaluated as clinically indicated and the underlying disorder addressed.

•Post-splenectomy – No further investigation is warranted for thrombocytosis after splenectomy.

•Suspected hematologic malignancy – Essential thrombocythemia, polycythemia vera, or another myeloproliferative neoplasm or hematologic malignancy should be suspected in a patient with erythromelalgia, pruritus, constitutional symptoms, splenomegaly, or an abnormal blood smear (e.g., nucleated red blood cells, teardrop cells, blasts).

Further evaluation for a myeloproliferative neoplasm or other hematologic malignancy should include testing for mutated JAK2, CALR, MPL, and BCR::ABL1, as described separately.

•Family history of thrombocytosis – An inherited disorder may be suspected in an individual with primary relatives who have unexplained thrombocytosis, leukemias, or characteristic skeletal, skin, or other somatic anomalies. Evaluation and diagnosis of familial causes of thrombocytosis are described separately.

[love-reincarnate]

@hush-little-darling Don’t expect me to sympathise with you just because you have blood cancer and Polycythemia Vera. You’re still a little bitch. Fuck you.

[sudnormal]

The truth is, I also share the headcanon that Anger suffers from migraines but at the same time not that kind of migraine, so some headcanons about this (au human/au elements):

okay, most of my life I have spent with a circle of people with this pain (my dad mostly) and most of them share something, he suffers from a disease that makes his blood the 2 thickest of what he would see, that's why not enough blood/oxygen arrives. to the arteries of the brain and this causes pain when being in a bad mood too much. It not is exactly polycythemia vera but it is something similar. I think it could be its kind of vascular migraine.

-I think that because of this he is very resistant to pain since most treatments that seek to relieve pain are injections or pills with side effects (tramadol for pain, nifedrigramin for sleep, clonasepal for tachycardia caused by tramadol , migretil for headaches, etc...)

-fear helps him a lot to administer his medications correctly (I have the head canon that fear is a doctor pr something)

-one of the recommendations is not to try to get angry but it never works

I wanna be a doctor :3

[wool-string]

I’ve had an idea for deadman wonderland Ajin au

So Kei doesn’t die in the truck accident but his classmates do n he gets framed for pushing them, even though he was also hit

Kai follows him to prison to keep him safe but because Kai is a normal human he gets put in the general area n Kei goes to the other section.

I gave him claws but I think Tanaka would suit claws more n I’ll give Kei a full ibm armor. Also Kei with polycythemia Vera so he’s making enough blood to upkeep that giant bloody ghost armor

Kou maybe with anemia?? So his weapon doesn’t last at all. That’s all I can think of to make him accurate to plot.