#parkinsons

[mindblowingscience]

A colossal study has revealed a variation of a gene involved in an immune response has been secretly giving protection to the billions who carry it from Alzheimer's and Parkinson's disease. Known as DR4, the variant, or allele, is part of a family of genes that normally help our immune system pinpoint and destroy foreign invaders, like bacteria and viruses. "In an earlier study, we'd found that carrying the DR4 allele seemed to protect against Parkinson's disease," says psychiatrist and geneticist Emmanual Mignot from Stanford University in the US, the institution that led the study. But Alzheimer's and Parkinson's are distinct conditions with different pathological biomarkers in the brain – Lewy bodies for Parkinson's, and abnormal tangles of a protein called tau in Alzheimer's. Discovering DR4 as a common factor was astounding.

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[willowreader]

https://movementdisorders.onlinelibrary.wiley.com/doi/full/10.1002/mds.29116

Click on the link above for the article.

[augmentedpolls]

Neurodevelopmental disorders examples: ADHD, autism, dyslexia, dyscalculia, sensory processing disorder

Neurological disorders examples: epilepsy, Parkinson’s, Alzheimer’s, MS

[randomtheidiot]

Prion disease: A disease caused by a misfolded protein that burns holes in the brain and always kills. Can have a late start (anywhere from 2 to 5 years) but always causes the same symptoms, which look nothing like autism and will kill you within months or even weeks of onset. Basically a zombie virus that eats your brain from the inside out and makes you lose control of your mind and body. Causes hallucinations, rapid decline in mental function to the point of nonsentience, convulsions, abnormal movement like walking in circles, loss of ability to eat, sleep and breathe and eventually death. None of these symptoms look like autism.

Forest rangers: Doing their goddamn jobs and getting blood samples from the local deer population to test for diseases. They’ve been doing this practically since the technology first became available and they’ve filmed the process extensively. They are so open about doing this that they write it all down in excruciating detail and publish it in news articles. This is where the CWD and other disease reports come from, and they would naturally do more of this if there’s more reason to suspect a disease outbreak.

Autism: You’re born with it. It has been diagnosed more frequently due to advancements in neuroscience. It also happens to look and function nothing like prion disease and it doesn’t fucking kill you within weeks of a diagnosis.

Some conspiracy nut: Hurr durr the government is injecting zombie diseases into deer to give humans autism and that’s definitely how autism works and also I’m not crazy and I don’t need therapy, you’re just a sheep and I’m too smart for you liberals to ever possibly understand.

Get your tinfoil hat wearing head out of your ass and either figure out just what the fuck you’re talking about or keep your mouth shut and don’t make yourself look like a jackass in front of people who do. Fear mongering doesn’t work if you’re an idiot.

[softzindagi]

one of the hardest thing being a caregiver is the mental decline you end up witnessing. my dad has hallucinations and delusions, and it’s hard to see because he’s not the same dad i had even last year. he doesnt smile or joke the same, he becomes agitated and mad often, and he is just slower in general. it breaks my fucking heart, i wish i could see him smile and laugh again. but often he is dazed, in pain, or coughing up and barely recovering from pneumonia. i just wish things were different. i wish the hallucinations and delusions were gone and he was healthy. but parkinsons is an insane disease, and it’s taken everything from my father way too quickly.

[spookietrex]

Had a neurologist appointment today that went really well. It was nice to just be...heard for once. I started in on my "my doctors aren't listening to me and are making things up" speech and she started to cut me off until I cut her off and explained that a certain hospital near us had actually documented in my medical record that I'd thrown up on purpose. (I didn't. They'd asked about nausea but unfortunately I'm dissociative in the hospital...especially if you're trying to involuntarily hospitalize me) and she stopped. She documented my symptoms and referred me to another provider who can actually help evaluate me for Parkinsons because my symptoms are more than just functional neurological disorder and I'm tired of being dismissed. She actually watched my videos of my tremoring and my muscles convulsing involuntarily and it switching sides.

[bpod-bpod]

Conversation Starters

Neurons communicate with chemicals – bursts of neurotransmitters which pass signals from one cell to the next. While the brain’s millions of neurons may look a little chaotic, their chemical chatter is in a fine balance that changes with age and disease. Normally, dopaminergic neurons squirt a neurotransmitter called dopamine into different brain areas, influencing processes such as movement, reward and motivation. Here researchers grow human dopaminergic neurons (highlighted in orange) from stem cells in a dish. With so many important roles in the brain, they investigate how the cells deteriorate in Parkinson’s Disease – specifically, how a toxic chemical called alpha-synuclein (which builds up in Parkinson’s) affects the cultured cells. The next step is to see if new drugs can slow down or stop alpha-synuclein, staving off symptoms.

Written by John Ankers

Winning image by Nick Gatford of the Nuffield Department of Clinical Neurosciences

Image category of the University of Oxford's Department of Biochemistry Centenary Scientific Imaging Competition

Image copyright held by Nick Gatford

Research published in Nature Communications, June 2021

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[ricisidro]

A peer-reviewed study on macaque monkeys showed a disturbing increased presence of tau proteins and the consequential neurodegeneration and neuro inflammation of the glial cells in all monkeys, published in the journal Alzheimer's and Dementia (2024).

#SARSCoV2 #COVID19 #braininflammation #Parkinsons #dementia #Alzheimers #memoryloss #cognitive

https://alz-journals.onlinelibrary.wiley.com/doi/pdf/10.1002/alz.13868

[denimixart]

Na chorobę Parkinsona zapadają coraz młodsi.... Dwadzieścia kilka lat to nie jest czas na Parkinsona, a jednak zdarza się. ☹️

Jak powiedział profesor Jarosław Sławek, specjalista w dziedzinie neurologii:

"Chorują rzeczywiście coraz to młodsi pacjenci. Szacunkowo do 2040 roku na świecie ma już chorować 16 milionów ludzi dzisiaj to jest około 6-8 mln, czyli ta liczba będzie naprawdę wzrastać… “

[kp777]

Study of 500,000 Medical Records Links Viruses With Alzheimer's Again And Again : ScienceAlert

A study of around 500,000 medical records suggested that severe viral infections like encephalitis and pneumonia increase the risk of neurodegenerative diseases like Parkinson's and Alzheimer's.

[mindblowingscience]

We know that what we eat and drink has a significant impact on our health, and a new study has found another connection between drinking coffee and being less likely to develop Parkinson's disease. Looking at data collected on 184,024 individuals across an average of 13 years, the international team of researchers behind the study found that coffee consumers had a lower risk of getting Parkinson's than those that didn't drink coffee at all. Further analysis of a sample of hundreds of people with Parkinson's measured levels of the primary metabolites of caffeine, paraxanthine, and theophylline, in the blood – finding that they had an inverse association with the risk of developing Parkinson's.

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[whats-in-a-sentence]

The micrographs in figure 24.20 show that one sHsp, αB-crystallin, prevents in vitro amyloid fibril formation by the protein α-synuclein, the major component of Lewy body deposits in Parkinson's disease.

"Chemistry" 2e - Blackman, A., Bottle, S., Schmid, S., Mocerino, M., Wille, U.

[cherylreeves]

My daddy fought a long battle with #Parkinson’s and #PTSD from Vietnam war. He loved God and honoured him. He is in Heaven now. Can I be relieved for him and yet just so sad too? #Grief #mourning #processing

[metalheadsforblacklivesmatter]

-fae

[softzindagi]

google is quite possibly the worst thing as an anxious caregiver watching and caring for my father who is on a feeding tube and has parkinsons and dementia. Reading everything and looking up things and just, feeling all kinds of despair bc every time i read the word end stage, it just breaks my fucking heart further and further. And its the looking knowledge that im watching my dad in the horrible stage and not being able to fucking do anything but care for him and hope for miracles to happen. His parkinsons and dementia seems to have progressed ten fold, exponentially getting worse and i just dont know what to do or how to deal with this. I feel like im one more horrible thing away from losing it completely. Theres something called caregivers grief, where you watch your loved one through all the stages of decline, scrambling to help and fix them, but the decline just keeps progressing. You watch every bit of it, heartbroken and grief stricken, theres nothing you can do to stop it. I just want him to be better and back to who he was even six months ago, but thats not possible and it fucking hurts so much.