#nobuo tomizawa

[foxspeterpan]

[thebutcher-5]

Lupin III - Le profezie di Nostradamus

Lupin III – Le profezie di Nostradamus

Benvenuti o bentornati sul nostro blog. Negli ultimi articoli abbiamo discusso di alcuni film tratti dalle opere di Stephen King. Dei film molto interessanti per vari motivi: la loro produzione turbolenta come Unico indizio la luna piena, per il divertimento e l’intrattenimento che riesce a portare come L’occhio del gatto e soprattutto per l’enorme macello registico e di sceneggiatura da far…

[cinemacuervo]

Lupin III: Adiós a Nostradamus (1995)

Lupin III: Adiós a Nostradamus (1995)

Título original: Rupan sansei: Kutabare! Nastradamus (Lupin III: Farewell to Nostradamus) Director: Shunya Ito, Takeshi Shirado, Nobuo Tomizawa Año: 1995 Género: Animación / Aventuras País: Japón Duración: 100 min Idioma: Español latino SINOPSIS: Una nueva aventura del exquisito ladrón de guante blanco conocido como Lupín. En este caso deberá robar las profecías perdidas de Nostradamus,…

[falconlord5]

The Prometheon

Your politics are bad and you should feel bad

Story by Alan Burnett and Stan Berkowitz

Written by Stan Berkowitz

Directed by Nobuo Tomizawa

Yeah, are all American generals psychotic assholes? Like, is there a screening process or something?

Hardcastle would vote for Trump

That’s so Jack Kirby it hurts

Hardcastle is a xenophobic nutjob, but he’s not wrong here. The life of one living creature is not worth the risk of an asteroid hitting Earth. Not one that size.

Should’ve blown up the asteroid.

And he’s not going to be bothered by the explosives anyway.

That’s a really bad idea, Supes.

Oh look, a moron on a cruise

Ouch, Lois.

Why do Americans hate the metric system so much?

Double suns would provide more heat than city could

That sounds like Jennifer Hale

Those tanks and artillery are awfully close to the monster. 

While I don’t think this is a very good episode, it’s a pretty classic Superman type story

Superman created by Jerry Siegel and Joe Shuster

Animated by TMS

[recentanimenews]

"Ramen Fighter Miki" Provides Service With a Smile

  Order Up.

  Online anime streaming is a virtual smorgasbord of choices, but you can't always tell just by looking at the buffet whether you'll like a particular dish or not. “Cruising the Crunchy-Catalog” is here to whet your appetite. Each week we provide additional information and cultural context in order to help anime fans decide whether or not they'd like to try out something new.

    What's Ramen Fighter Miki?

  Ramen Fighter Miki is a 2006 TV anime with direction by Nobuo Tomizawa and animation by Telecom Animation Film. The series is based on the Muteki Kanban Musume (“Invincible Poster Girl”) manga by Jun Sadogawa, which was serialized from 2002 – 2007 in Akita Shoten's Weekly Shōnen Champion manga magazine. Crunchyroll descibes Ramen Fighter Miki as follows:

    In a world where terror grips the land and innocents have no solace from violence and brutality, one girl walks the line between life and death to bring her own special brand of... Ramen! Miki Onimaru works at her parent's Ramen shop, making deliveries, waiting tables, and attracting customers with cute, girlish charm. Somehow, Miki can't complete even one of these simple tasks without the full employment of her extensive bone-crunching, skull-splitting martial arts moves and penchant for unleashing relentless destruction. Can Miki get through the day without messing up and angering her Mom, who makes her look like a gentle kitten in comparison?

    Ramen Fighter Miki is a comedy predicated on single premise: the main character, Miki Onimaru, is both singularly violent and terrible at her job. Although she works at her family's Chinese restaurant in an ordinary Japanese shopping center, Miki acts like she's the protagonist of Fist of the North Star, unleashing secret killer moves that get their own on-screen Kanji and generally terrorizing her neighbors at the grocery store and bakery.

    A History of Violence.

  Although Ramen Fighter Miki's brand of comedy primarily relies on a steady application of slapstick violence, the show also incorporates elements of parody, poking fun at such genre staples as martial arts films (complete with exaggerated techniques and training montages), horror movies, and youth sports dramas. There's even an episode that lampoons Super Sentai-style tokusatsu TV shows.

    TV Safety.

  Back when cathode ray televisions with a 4:3 aspect ratio were the industry standard, Japanese animation was produced such that the most important action was always within the center of a 4:3 frame. Anything outside of that area (which was referred to as “TV safety”) wouldn't appear on camera in the final product, and so animators would often scribble things (production notes, doodles, dirty jokes) in the margins of the cels.

    With the rise of LCD and plasma screen televisions with widescreen aspect ratios, some of the sight gags in Ramen Fighter Miki don't quite translate. One running joke involves the character of Tomoka Kayahara, a kind-hearted teacher whose sour expression causes people to mistake her for a vengeful spirit. When Tomoka appears, she's accompanied by the kind of glitches and distortion that indicate electromagneticl interference in a cathode ray projector. Modern TVs don't really glitch in that manner.

    Expect the Unexpected.

  Although Ramen Fighter Miki is completely dedicated to its bizarre premise and Miki's total warfare with childhood friends and the neighborhood dog make up the bulk of the humor, the show also keeps its comedy fresh by playing fast and loose with the audience's expectations. Many jokes seem to be going in one direction, only to swerve at the last moment into completely tangential absurdity.

    Tune In, Turn On, Take Out.

  Crunchyroll currently streams Ramen Fighter Miki in the United States, Canada, Puerto Rico, American Samoa, Guam, the US Virgin Islands, and the United States Minor Outlying Islands. The series is available in the original Japanese language with English subtitles.

    Ramen Fighter Miki was also released on DVD in North America by Media Blasters under their Anime Works label, and an English language version of the original Muteki Kanban Musume manga was published by ADV Manga under the title Noodle Fighter Miki, but these releases are now out-of-print.

    Comedy can be an acquired taste, but each episode of Ramen Fighter Miki is easily digested and likely to leave viewers hungry for more. If you're in the mood for a heaping helping of humorous violence topped with thoroughly foolish characters turning the ordinary and the everyday into the extraordinary and the bizarre, please consider giving Ramen Fighter Miki a try.

    Is there a series in Crunchyroll's catalog that you think needs some more love and attention? Please send in your suggestions via e-mail to cruisingcrunchy@gmail.com or post a Tweet to @gooberzilla. Your pick could inspire the next installment of “Cruising the Crunchy-Catalog”!

  Paul Chapman is the host of The Greatest Movie EVER! Podcast and GME! Anime Fun Time.

By: news+feed@crunchyroll.com

[cancersfakianakis1]

Determination of poor prognostic immune features of tumour microenvironment in non-smoking patients with lung adenocarcinoma

Publication date: November 2017 Source:European Journal of Cancer, Volume 86 Author(s): Tomonari Kinoshita, Chie Kudo-Saito, Reiko Muramatsu, Tomonobu Fujita, Miyuki Saito, Haruna Nagumo, Toshiharu Sakurai, Shinobu Noji, Emi Takahata, Tomonori Yaguchi, Nobuo Tsukamoto, Yuichiro Hayashi, Kaoru Kaseda, Ikuo Kamiyama, Takashi Ohtsuka, Kenji Tomizawa, Masaki Shimoji, Tetsuya Mitsudomi, Hisao Asamura, Yutaka Kawakami We have previously demonstrated that the prognostic significance of tumour-infiltrating CD8+ T cells significantly differs according to histological type and patient smoking habits in non-small cell lung cancer (NSCLC). This work suggested that infiltrating CD8+ T cells may not be activated sufficiently in the immunosuppressive microenvironment in non-smokers with adenocarcinoma. To understand the immunogenic microenvironment in NSCLC, we characterised immune cells comprehensively by performing an immunohistochemical evaluation using an alternative counting method and multicolour staining method (n = 234), and assessed immune-related gene expression by using genetic analytical approaches (n = 58). We found that high infiltration of activated CD8+ T cells expressing interferon gamma (IFN-γ) and granzyme was correlated with postoperative survival in patients with non-adenocarcinoma. On the contrary, CD8+ T-cell accumulation was identified as a worse prognostic factor in patients with adenocarcinoma, particularly in non-smokers. Infiltrating CD8+ T cells were significantly less activated in this microenvironment with high expression of various immunoregulation genes. Potentially immunoregulatory CD8+ FOXP3+ T cells and immunodysfunctional CD8+ GATA3+ T cells were increased in adenocarcinoma of non-smokers. CD4+ FOXP3+ regulatory T cells expressing chemokine receptor-4 (CCR4)- and chemokine ligand (CCL17)-expressing CD163+ M2-like macrophages also accumulated correlatively and significantly in adenocarcinoma of non-smokers. These characteristic immune cells may promote tumour progression possibly by creating an immunosuppressive microenvironment in non-smoking patients with lung adenocarcinoma. Our findings may be helpful for refining the current strategy of personalised immunotherapy including immune-checkpoint blockade therapy for NSCLC. http://ift.tt/2yjQCwQ

[recentanimenews]

"Ramen Fighter Miki" Provides Service With a Smile

  Order Up.

  Online anime streaming is a virtual smorgasbord of choices, but you can't always tell just by looking at the buffet whether you'll like a particular dish or not. “Cruising the Crunchy-Catalog” is here to whet your appetite. Each week we provide additional information and cultural context in order to help anime fans decide whether or not they'd like to try out something new.

    What's Ramen Fighter Miki?

  Ramen Fighter Miki is a 2006 TV anime with direction by Nobuo Tomizawa and animation by Telecom Animation Film. The series is based on the Muteki Kanban Musume (“Invincible Poster Girl”) manga by Jun Sadogawa, which was serialized from 2002 – 2007 in Akita Shoten's Weekly Shōnen Champion manga magazine. Crunchyroll descibes Ramen Fighter Miki as follows:

    In a world where terror grips the land and innocents have no solace from violence and brutality, one girl walks the line between life and death to bring her own special brand of... Ramen! Miki Onimaru works at her parent's Ramen shop, making deliveries, waiting tables, and attracting customers with cute, girlish charm. Somehow, Miki can't complete even one of these simple tasks without the full employment of her extensive bone-crunching, skull-splitting martial arts moves and penchant for unleashing relentless destruction. Can Miki get through the day without messing up and angering her Mom, who makes her look like a gentle kitten in comparison?

    Ramen Fighter Miki is a comedy predicated on single premise: the main character, Miki Onimaru, is both singularly violent and terrible at her job. Although she works at her family's Chinese restaurant in an ordinary Japanese shopping center, Miki acts like she's the protagonist of Fist of the North Star, unleashing secret killer moves that get their own on-screen Kanji and generally terrorizing her neighbors at the grocery store and bakery.

    A History of Violence.

  Although Ramen Fighter Miki's brand of comedy primarily relies on a steady application of slapstick violence, the show also incorporates elements of parody, poking fun at such genre staples as martial arts films (complete with exaggerated techniques and training montages), horror movies, and youth sports dramas. There's even an episode that lampoons Super Sentai-style tokusatsu TV shows.

    TV Safety.

  Back when cathode ray televisions with a 4:3 aspect ratio were the industry standard, Japanese animation was produced such that the most important action was always within the center of a 4:3 frame. Anything outside of that area (which was referred to as “TV safety”) wouldn't appear on camera in the final product, and so animators would often scribble things (production notes, doodles, dirty jokes) in the margins of the cels.

    With the rise of LCD and plasma screen televisions with widescreen aspect ratios, some of the sight gags in Ramen Fighter Miki don't quite translate. One running joke involves the character of Tomoka Kayahara, a kind-hearted teacher whose sour expression causes people to mistake her for a vengeful spirit. When Tomoka appears, she's accompanied by the kind of glitches and distortion that indicate electromagneticl interference in a cathode ray projector. Modern TVs don't really glitch in that manner.

    Expect the Unexpected.

  Although Ramen Fighter Miki is completely dedicated to its bizarre premise and Miki's total warfare with childhood friends and the neighborhood dog make up the bulk of the humor, the show also keeps its comedy fresh by playing fast and loose with the audience's expectations. Many jokes seem to be going in one direction, only to swerve at the last moment into completely tangential absurdity.

    Tune In, Turn On, Take Out.

  Crunchyroll currently streams Ramen Fighter Miki in the United States, Canada, Puerto Rico, American Samoa, Guam, the US Virgin Islands, and the United States Minor Outlying Islands. The series is available in the original Japanese language with English subtitles.

    Ramen Fighter Miki was also released on DVD in North America by Media Blasters under their Anime Works label, and an English language version of the original Muteki Kanban Musume manga was published by ADV Manga under the title Noodle Fighter Miki, but these releases are now out-of-print.

    Comedy can be an acquired taste, but each episode of Ramen Fighter Miki is easily digested and likely to leave viewers hungry for more. If you're in the mood for a heaping helping of humorous violence topped with thoroughly foolish characters turning the ordinary and the everyday into the extraordinary and the bizarre, please consider giving Ramen Fighter Miki a try.

    Is there a series in Crunchyroll's catalog that you think needs some more love and attention? Please send in your suggestions via e-mail to cruisingcrunchy@gmail.com or post a Tweet to @gooberzilla. Your pick could inspire the next installment of “Cruising the Crunchy-Catalog”!

  Paul Chapman is the host of The Greatest Movie EVER! Podcast and GME! Anime Fun Time.

By: news+feed@crunchyroll.com