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does anyone actually build a detailed linkedin profile. you've got to be fucking with me
#💀💀💀💀💀💀💀💀💀💀💀#we are at the stage that i am literally looking up 'how to write a good cover letter/resume'#and then some of the tips are literally 'networking'#bro i swear to god. has job hunting always been like this#why do u gotta be ur own fucking marketing team these days just to get a job. god#im speaking as someone who basically has no experience LMAO </3#and thr experience i Do have. i dont have any metrics to attach LMAO in some cases thats on me#didnt realise i had to know this shit lmao. also my MEMORY IS BAD AND I NEVER SAVED ANYTHING
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5 Best Social Media Marketing Tips https://www.blatheringsblog.com/best-social-media-marketing-tips-for-small-companies/
#achieve your business goals#Best Social Media Marketing#Best social media marketing tips#Best Social Media Marketing Tips For Small Companies#grow your online presence#social media marketing strategy#social media marketing strategy mastery#social media marketing team#social media marketing tips#Social media strategy guide#Social networking#The importance of social media#What is social media marketing
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Mastering the Art of Multi Level Marketing: Strategies for Growth and Success
Multi Level Marketing (MLM) has gained popularity in recent years as a viable business model for individuals looking to generate income through network building and sales. Understanding the basics of MLM is crucial for anyone looking to succeed in this industry. At its core, MLM involves selling products or services through a network of distributors. These distributors earn commissions not only…
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Essential Skills for Successful Network Marketing Professionals
The post reflects experiences from network marketing, focusing on lessons learned from Erich Worre. It emphasizes the importance of skills, attitude, and ongoing practice in developing leadership. Key strategies include effective communication.
Inspired by Erich Worre’s seminar Professionals for teamwork in Network Marketing Business are challenging to be found. When I used to be involved with Multi Level Marketing, I watched many seminars on leadership, business development, and teamwork. I followed mostly Erich Worre and John Maxwell. The things I learned back then were useful for improving the business. In that post, I share what…
#Business#Goals#Leadership#Multi Level Marketing#Network Marketing#Professionals#Prospects#Team#Time Management
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ADD SHOP E RETAIL LTD. ने समस्तीपुर, बिहार में 1ST Mega Seminar का आयोजन किया
Network Marketing News: ADD SHOP E RETAIL LTD ने 15 नवंबर 2024 को समस्तीपुर में 1ST Mega Seminar का सफलतापूर्वक आयोजन किया। इस कार्यक्रम का आयोजन Team Sankalp (BIHAR) द्वारा किया गया था, जिसमें मुख्य अतिथि के रूप में Mr. Deepak Kumar Singh, Founder Team Sankalp, विशेष रूप से उपस्थित रहे। इस सेमिनार का मुख्य उद्देश्य जैविक खेती और व्यापार के अवसरों के ��ारे में जागरूकता फैलाना था। कार्यक्रम की…
#directsellingnow#1ST Mega Seminar#Add Shop E Retail Ltd#ADD SHOP E RETAIL LTD.#Business Building Seminar#Direct selling Industry#Direct Selling News in Hindi#Direct Selling Now (DSN)#Founder Team Sankalp#Mr. Ajay Kumar#Mr. Deepak Kumar Singh#Mrs. Anima Devi#Network Marketing (MLM)#डायरेक्ट सेलिंग ताज़ा ख़बरें#नेटवर्क मार्केटिंग समाचार
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Supernatural *is* a horror show first and foremost.
it has been said before but i feel the need to state again that the finale of supernatural is not only the most insane case of accidentally making a soul crushing psychological horror while trying to make a satisfying conclusion but the only case of that happening ever (at least to my knowledge.) i’ve seen bad tv endings, but never a tv ending that was trying to be comforting instead telling me that all of my worst nightmares are true and that me and the ones i hold close will never ever love openly without fear. again, so many before me have made this point but god. they killed him on rebar. he never got to be free
#this at least helps me appreciate the ending#horror is often used for social commentary#and the fact that this bi male character thought his life would end brutal and bloody and alone 15 years before#and the fact that *nothing had changed* after all#that he died the same death and *gave up* bc his reason for fighting (love) was lost to him forever when cas was sent to the Empty#that he was on this hamster wheel that drove him to near madness and even when he defeated it the real world (OURS)#couldn't handle an ending where he was happy in love with another man is a slam dunk for the writing team#if youre mad at the ending dont direct your anger at the writers. they were *very* clear esp in the last season that this was their goal#you can kill network exec Chuck in the show but the real-life execs still will not allow dean to live#and this is *after* market research presumably demonstrated that it wasnt profitable enough commit to destiel#that is a *societal* problem and a *financial* problem that even our most beloved queer characters haven't earned enough of#our approval to LIVE! how horrifying! how terrible#how visceral and real yet only those primed by sympathy to queer hardship would even see it as such#ANOTHER horror that even our deaths arent mortifying enough to a majority of people#i thought i hated the ending but the more i think on it and read btwn the lines#the more it makes sense. none of this is an accident and the writers were begging us to understand that their hands were tied by other#forces that they ultimately failed to defeat but they *could* call out several issues and deliver a pyrrhic victory#they showed us artistic censorship has the potential to be *deadly*. they showed us that some people can give everything they have and#still be considered disposable due to (insert marginalized status here - note that eileen charlie - and her partner - resoultion)#and cas do not get on-screen resolutions to their stories)#and this ending *still* haunts those that *do* give a shit years later#this is a horror show and the horrors never ceased they just framed it as a happy ending and hoped we would accept this brutality as closure#and for many it was. the rest of us cant rest in peace knowing how easy dean and cas were to throw away for so many.#spn text rant#>?[#supernatural#spn s15#chuck won
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A new local creative cafe venture - jumping in
When discussing this idea with a friend recently, expecting everyone to talk me out of it, I realised that every time I had considered a new venture or starting down any path if anything ahead was not visible, I got serious cold feet. The other realisation I had was that everything I have done, which was worthwhile – including a course during 2020 that paid a stipend and turned out better than…
#Becoming a new business owner#business#buying your first real business#coffee#creating a social hub#female business strategy#finding a purpose#food#gathering information#Ideas for Asset Rich Cash Poor Entrepreneurs#implenenting new ideas#lifestyle business#lifestyle business ownership#making savings and efficiencies#marketing strategy and implementation#news#nuts and bolts#nuts and bolts of running a business#Ongoing concern#planning to take a leap into business ownership#Posted inHanging local artists work on walls of a cafe#running a team#seed network#side hustle#Solo Singer Songwriters and opening the talent bottleneck#starting a business#Starting a local business#taking on a retail or online business#Taking on a Running Business#team leadership
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#networker#networkmarketing#networking#business#mlm#network#lifestyle#marketing#entrepreneur#success#liderazgo#motivation#negocios#emprende#multinivel#marketingdigital#lavoroonline#mindset#emprendedores#networkmarketingitalia#lavorodacasa#emprendedor#team#businessonline#businesswoman#exito#entrepreneurship#workfromhome#emprendedora#onlinebusiness
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Website Designing Company Near Me
Best Website Designing Company Near Me @PICKMYURL +919819595495 #pickmyurl
#aimarketing #business #infinity #marketing #team #networkmarketing #artificialintelligence #aimarketer #aiadvertising #aidigitalmarketing #pickmyurl #digitalmarketing #digitalmarketingagency #socialmediamarketing #india #businessmarketing #facebookmarketing #marketingautomation #linkedinmarketing #instamarketing #instagrammarketing #youtubemarketing #websitedesigning #webhosting #seo #aimarketingcompany #aiagency #aimarketingagency
#ai-marketing#business#infinity#marketing#team#network-marketing#artificial-intelligence#ai-marketer#ai-advertising#aidigitalmarketing#pickmyurl
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Best AI Marketer in India
Power of AI Marketing @PICKMYURL +919819595495 #pickmyurl
#aimarketing #business #infinity #marketing #team #networkmarketing #artificialintelligence #aimarketer #aiadvertising #aidigitalmarketing #pickmyurl #digitalmarketing #digitalmarketingagency #socialmediamarketing #india #businessmarketing #facebookmarketing #marketingautomation #linkedinmarketing #instamarketing #instagrammarketing #youtubemarketing #websitedesigning #webhosting #seo #aimarketingcompany #aiagency #aimarketingagency
#ai-marketing#business#infinity#marketing#team#network-marketing#artificial-intelligence#ai-marketer#ai-advertising#ai-digital-marketing#pickmyurl#digital-marketing#digital-marketing-agency#social-media-marketing#india#business-marketing#facebook-marketing#marketing-automation
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gyancareer
#Our study abroad agency#located in the center of Bangalore's busy MG Road#works as a spotlight for students looking to study abroad#pointing them in the direction of a future filled with adventures and knowledge from around the world.#Why Choose Us?#As the top study abroad consultant in MG Road#Bangalore#we pride ourselves on providing personalized and comprehensive services that cater to the unique needs of each student. Our team of dedicat#ensuring a seamless transition from aspirations to reality.#Expert Guidance at Your Fingertips#Choosing the right study abroad consultant near you is crucial#and our prime location in MG Road makes us easily accessible. Our knowledgeable consultants are equipped with the latest information on int#courses#and admission procedures. This#combined with our extensive network#empowers us to offer you the best advice for your academic journey.#Genuine and Trustworthy Services#In a market flooded with options#we stand out as the best study abroad consultant in Bangalore due to our commitment to transparency and integrity. Our reputation as a genu#with countless success stories attesting to our unwavering dedication to client satisfaction.#Comprehensive Overseas Education Support#Ranked as the No.1 study abroad consultant in Bangalore#we go beyond the basics. Our services encompass not only academic guidance but also comprehensive support for visa and immigration processe#we strive to ensure a hassle-free experience#allowing you to focus on your academic journey.#Top-tier Visa and Immigration Assistance#Our commitment to excellence extends to being the best visa and immigration consultant in Bangalore. Navigating the complex visa processes#ensuring that you meet all requirements and deadlines with confidence.#In conclusion#our study abroad consultancy in MG Road
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Can You Make Money With Optavia
Optavia is a Baltimore based health and wellness company. There is a wide range of Optavia products, ranging from muesli bars and snacks, to pre-made meals.
They were formerly known as Medifast, but have now decided to rebrand themselves as Optavia, and sell their weight loss and dietary products through multi-level marketing. Here at The Finance Guy, we have the opinion that you can’t make money with MLM, but we are happy to be proven wrong, so we’ll have closer look and ask can you make money with Optavia
How do you make money with optavia
To find out how you can make money in this MLM, we looked at a copy of the Optavia Compensation Plan. This document explains all the ways you can make money as an Optavia coach, as well as what you need to do in order to qualify for commissions.
The first thing that stands out is that they tell us that this compensation plan gives Optavia coaches the ability to shape their destinty and create a life of greater momentum. It’s not the first time we’ve heard similar claims in a compensation plan, but we’ll keep going.
They tell us that to earn from all 9 of their potential income streams, Optavia coaches need to be competent in 3 areas which are: - Client Support - Team Buiding - Leadership Development
Before they go into 9 ways Optavia coaches make money, they first explain that with Optavia, there are 2 types of Volume. Compensation Volume (CV) and Qualifying Volume (QV)
Compensation Volume is used to calculate how much commission coaches can earn. All Optavia products have a CV between 0% and 100%. Commissions are based on these values. Coaches will also earn CV from people they sponsor. Coaches they personally sponsored are shown as Frontline Compensation Volume (FCV). Coaches sponsored by others in their downline will contribute to their Group Compensation Volume (GCV).
Qualifying Volume is used to help determine coaches rank in the Optavia system. Their rank will determine which commissions they do or don’t qualify to earn. Just as with CV, coaches can also earn Frontline Qualifying Volume (FQV) and Group Qualifying Volume (GQV).
Client Support Commission The amount of commission Optavia coaches can earn is shown in the table below:
As we see from this diagram, coaches can earn commission from their frontline volume. That is the people who they have personally sponsored to join Optavia. It starts at 15%, but increases if the coach is able to sponsor 5 different éntities’.
If you do sponsor 5 or more front line coaches, then you will qualify for the client support bonus. This will increase depending on the monthly volume ordered by the people in your frontline. If they order a combined volume of 6,000 points, you will earn the maximum bonus of 13%, taking your total Optavia client commissions to 28%
Coach Consistency Bonus If your frontline achieves certain qualifying volumes for 3 months in a row, then Optavia will pay you a lump sum bonus. The amounts your can earn are shown below: - 2,000 FQV = $250 - 4,000 FQV = $500 - 6,000 FQV = $1,000
While these bonuses are all well and good, it’s important to remember that the person who sponsored you into Optavia can also qualify for them. In other words, the person who sponsored you has a vested interest in making you spend large amounts on Optavia every month
Coach Accelerator Bonus This is what most MLMs refer to as a ‘fast start bonus’. Optavia makes this available to new coaches for their first 3 months. If you personally sponsor 3 frontline Optavia coaches, and they each buy 345 QV worth of product in a month, you will get a lump sum payment of $150. If you manage to do this with 5 new coaches, then they’ll give you $250.
Accelerator Assist Bonus If someone you personally sponsored earns a Coach Accelerator Bonus, then you will also get paid the same amount.
These accelerator bonuses are a nice way to reward new coaches who ‘hit the ground running’. Having said that, they also create an incentive for the person who sponsored you to make you spend as much as possible as soon as you join. After all they need you to spend 345 QV or you won’t be eligible for their accelerator bonus. The person who sponsored them will be equally enthusiastic to make you spend because they too will get the bonus.
We might think that the Optavia accelerator bonuses are designed to make people sponsor new coaches and get them spending as much as possible as quickly as possible.
Team Growth Bonus This is Optavia’s version of what other MLMs would call ‘downline commissions’. Optavia coaches can only start earning this payement once they achieve the rank of ‘Senior Coach’ with Optavia. The amount of commission they earn from their down line will depend on their rank as shown in the table below:
While it’s nice that Optavia is willing to pay all these commissions, it does mean that 32% of the price Optavia Coaches pay for any products goes to their upline as a team growth bonus. On top of that up to 28% will be paid to their sponsor as a client support commission.
While they may tell you how exciting it is that you can earn all these commissions, we think it’s important to remember that 60% of what you pay for your Optavia products, goes to your upline as commission. You should also keep in mind that this is before Optavia has made any profit for themselves.
A universal challenge we find with all MLMs, is that their products or services have to be very expensive in order to include all the layers of commission offered by the MLM compensation plan.
Fully Integrated Business Coach Consistency Bonus The compensation plan tells us that you can reach a level of mastery with Optavia if you achieve their level of Fully Integrated Business Coach (FIBC). As expected the qualifications for this are volume based. To become a FIBC, you will need: 6,000 Frontline Qualifying Volume At least 5 Front Line Optavia Frontline Senior Coach Teams 15,000 in total Group Qualifying Volume for the month
If you manage to achieve all these criteria for 3 consecutive months, then Optavia will pay you a bonus for the month of $1,000. The only way to obtain this bonus is if you have a very active downline who are purchasing a lot of Optavia products.
Once again, if you have recently joined, then your upline has a vested interest in making you buy as much Optavia products as possible every month
Executive Director Gerneration Bonus To qualify for this bonus, you must first achieve the Optavia rank of Regional Director or higher. The amount you can earn will depend on how many Éxecutive Director Teams’ you have in your Optavia downline. Each time someone in your downline reaches the Optavia rank of Executive director, that leg in your downline will qualify. You don’t need to have personally sponsored the Optavia coach who reaches the rank.
The amount of Optavia Director Generation Bonuses paid at each rank are showed in the table below:
As you climb the Director ranks within Optavia, you will qualify for more and more and more generations of bonuses..
Elite Leadership Bonus These are 3 additional bonuses of 0.5% each which are paid when Optavia coaches achieve the qualifying ranks for each bonus. The qualifying ranks are National Director, Global Director and Presidential Director. These bonuses are cumulative, so an Optavia coach who reaches the rank of Presidential director, will get paid all three elite leadership bonuses.
While it’s nice that you can earn all these bonuses, it’s important to remember that they represent a total of 13.5% of the price paid by coaches for Optavia products. If we include the commissions and bonuses we looked at previously, we see that when Coaches buy Optavia products, 73.5% of what they pay goes to their upline to fund the compensation plan. And this doesn’t include the other one of cash payments that coaches may earn.
Like all MLMs Optavia will tell us how proud they are of their generous compensation plans, we see it a a problem. If they are paying so much in their compensation plan, the only way the company can turn a profit, is to include it in the price paid by Optavia coaches in their MLM
How are optavia coaches promoted
In order to qualify for all the commission available in the Optavia compensation plan, coaches will need to get promoted through the ranks of their MLM.
To reach each level, coaches must reach a combination of sponsoring and volume quotas. This is shown in the table below:
Are Optavia coaches making money
To find out if they are making any money in this MLM, we looked a copy of the Optavia Income Disclosure. All they have given us is a table of earnings for the previous 12 months, with very little explanation.
For example Optavia have not explained how they selected the coaches who are included in their table. Looking at the first line, which is Optavia Coaches who earned nothing. We see that they represent 22.42% of all coaches, and they were active for an average 13 months. This seems like a high average. Maybe Optavia is only showing us the data for Coahces who were active for the entire 12 moths. They have not told us how many coaches quit during the year, but we are guessing that like most MLMs, it is a very substantial number
While we are not convinced we have all the information, from the table they have given us we can see that: - 22.42% of Optavia Coaches earned no income at all - 2.17% of Optavia Coaches earned over $50,000 for the year (enough to replace a full time job)
Even if Optavia have given us limited information with only their most active Coaches, it still shows us that 97.83% of active Optavia Coaches earned less than a full time income
Why is it difficult to make money with Optavia
To find out why it’s hard to make money from the Optavia business opportunity, we looked at Dr Jon Tayolors 5 Step MLM evaluation. This study looks at 5 potential red flags, and Dr Taylor explained that if any MLM raises any 4 of the 5, then they should be considered a product based pyramid scheme, and not a legitimate business opportunity. They are:
Red Flag 1 - Constant Recruitment of New Members There is a strong emphasis on recruitment in Optavia. They only way to earn some commissions such as the accelerator bonuses, is to ensure that new Optavia coaches are being constantly recruited into the downline. Optavia definitely raises red flag 1!
Red Flag 2 - Promotion Through Recruitment As we saw, the only way to climb the ranks with Optavia is to meet their qualifying criteria, which includes building a downline. It is therefore impossible to get promoted without recruitment. Based on this, Optavia raises red flag 2
Red Flag 3 - Pay to Play While there is no specified quota for coaches to remain active in Optavia, there is a requirement for their downline to have Group Qualifying Volume. So even if Optavia isn’t asking you to buy product every month, it’s very likely that your upline will be pressuring your to add to their GQV. Technically Optavia didn’t raise this red flag so we won’t count it.
Red Flag 4 - Most of the Rewards go to your upline Dr Taylor warns that the compensation plans of most MLMs results in extreme inequality of payouts, he estimates that while a few people at the top make a lot of money, 99.6% of people who join MLM will lose money.
As we already noted when looking at the various commissions paid in the compensation plan, 73.5% of the price paid by Optavia coaches goes to their upline as commission. It’s safe to say Optavia has raised this red flag.
Red Flag 5 - More than 5 levels in the payout plan Dr Taylor says 'Excessive levels in a downline is another sign participants are expected to sell primarily to their downline, rather than to the general public. This makes it an exploitative money transfer scheme, or product-based pyramid scheme'.
Optavia did not mention any limitations to the commission paid on their bonuses. Their compensation plan suggests commission is paid on the entire downline in your team. Even if someone reaches the high ‘director ranks’ the coaches above them at the equal or higher levels will receive some commission from their entire downline. Optavia definitely raises this red flag.
Based on our understanding Optavia has raised 4/5 red flags from Dr Taylors MLM evaluation system. His study found that any opportunity which raises 4 or more flags should be considered a product-based pyramid scheme.
Dr. Taylor estimated that 99.7% of participants will lose money in a business such as Optavia. The reason is that there is no real demand for the products being sold. The business is an endless recruitment chain in which only the very few at the top will make real money.
Should you join optavia
The first thing to be aware of before joining any MLM, is that it is a sales job. You are not owning your own business, and it’s not as simple as just telling a few friends to get on board with you. The only way to succeed will be to sell large amounts of the product and sign up large numbers of complete strangers into your downline.
Before you join Optavia, it would be a good idea to try some of the products and see if you would be willing to pay full price for them. At the end of the day, if you wouldn’t buy the products without being part of the compensation plan, then you can’t expect others to do so.
It might also be a good idea to look into some reviews of the Optavia diet. One review we read found that their system simply put people on a diet where their calorie intake was reduced to between 800 and 1200 calories a day. That is half the recommended caloric intake for an adult. In other words the Optavia diet is simply starving the weight off your body. While this may result in weight loss, it might not be healthy for everyone.
is Optavia an Illegal pyramid scam
Even though MLMs closely resemble pyramid schemes, they are not illegal. The reason dates back to the 1979 case of Amway vs the FTC. After 4 years in court Amway was found to be offering a business opportunity, rather than a pyramid scam. The technicalities came down to wording in their paperwork. One example requires consultants to make retail sales.
The Amway ruling effectively opened the doors for all other MLMs to operate within the law. However we should remember that being legal doesn’t make it ethical. If you knew that less than 1% of people had a chance of generating a real income, would you feel comfortable recruiting new consultants?
We also looked at the 2018 FTC Business Guidance for MLMS. The FTC explains that several activities used by MLMs to promote their business opportunities, may be misleading and unlawful.
Another issue, is that even though these rules may be in the paperwork, they are difficult to enforce. For example, several people in MLMs have said that they have cupboards full of product. This is because of the minimum monthly purchases they need to make to remain active in the system. Even though stockpiling is against the rules, there is no way for the company to monitor it.
Being legal does not make MLM ethical. All companies are in business with the goal of selling goods and services for a profit. Network marketing companies are able to charge a higher price because they create a customer base of loyal members who believe that by consuming these products and recruiting others to do so, they will become financially free. Keep in mind that making such promises is in breach of the FTC guidance.
As always, we’d love to hear your feedback about Optavia. Feel free to share your thoughts and feedback in the comments section below:
For more posts like this, look at our list of mlm reviews.
#Optavia#Optavia coach#make money with Optavia#optavia review#Optavia compensation plan#Optavia Income Disclosure#MLM#Network Marketing#Optavia Pyramid scheme#Optavia coach earnings#how much do Optavia coaches make#Optavia team bonus#Optavia integrated business coach bonus#Optavia FIBC#Optavia business coach#Optavia pyramid scheme#Optavia pyramid scam
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नेटवर्क मार्केटिंग से पैसे कैसे कमाएं, How to Earn Money from Network Marketing.
नेटवर्क मार्केटिंग नेटवर्क मार्केटिंग एक व्यापारिक प्रणाली है। जहा आप अपने नेटवर्क को उपयोग करके अपने उत्पादों और सेवाओं का प्रचार करते हैं। साथ ही नए सदस्यों को अपने बिजनेस में जुड़ाते हैं। इस तरीके में आपकी मेहनत और सामर्थ्य के हिसाब से आपकी कमाई को बढ़ाया जा सकता है। नेटवर्क मार्केटिंग एक व्यवसाय होने के साथ साथ एक संवाद का माध्यम भी है। जो आपके निर्माणात्मक और वित्तीय स्वतंत्रता का माध्यम बन…

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#Business Opportunities#Compensation Plans#Direct Selling#Entrepreneurship#Financial Freedom#Home-Based Business#MLM (Multi-Level Marketing)#MLM Success#MLM Training#Network Marketing Companies#Network Marketing Strategies#Network Marketing Tips#Passive Income#Sales and Recruitment#Team Building
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Mastering the Art of Multi Level Marketing: Strategies for Growth and Success
Multi Level Marketing (MLM) has gained popularity in recent years as a viable business model for individuals looking to generate income through network building and sales. Understanding the basics of MLM is crucial for anyone looking to succeed in this industry. At its core, MLM involves selling products or services through a network of distributors. These distributors earn commissions not only…
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"Engineers at the University of Pennsylvania have made a critical breakthrough that promises better outcomes for pregnancies threatened with pre-eclampsia, a condition that arises due to insufficient blood flow to the placenta, resulting in high maternal blood pressure and restricted blood flow to the fetus.
Pre-eclampsia is one of the leading causes of stillbirths and prematurity worldwide, and it occurs in 3 to 5% of pregnancies. Without a cure, options for these patients only treat symptoms, such as taking blood pressure medication, being on bed rest, or delivering prematurely—regardless of the viability of their baby.
Making a decision to treat pre-eclampsia in any manner can be a moral conundrum, to balance many personal health decisions with long-standing impacts—and for Kelsey Swingle, a doctoral student in the UPenn bioengineering lab, these options are not enough.
In previous research, she conducted a successful proof-of-concept study that examined a library of lipid nanoparticles (LNPs)—which are the delivery molecules that helped get the mRNA of the COVID vaccine into cells—and their ability to reach the placenta in pregnant mice.
In her latest study, published in Nature, Swingle examined 98 different LNPs and their ability to get to the placenta and decrease high blood pressure and increase vasodilation in pre-eclamptic pregnant mice.
Her work shows that the best LNP for the job was one that resulted in more than 100-fold greater mRNA delivery to the placenta in pregnant mice than an FDA-approved LNP formulation.
The drug worked.
“Our LNP was able to deliver an mRNA therapeutic that reduced maternal blood pressure through the end of gestation and improved fetal health and blood circulation in the placenta,” says Swingle.
“Additionally, at birth we saw an increase in litter weight of the pups, which indicates a healthy mom and healthy babies. I am very excited about this work and its current stage because it could offer a real treatment for pre-eclampsia in human patients in the very near future.”
While further developing this cure for pre-eclampsia and getting it to the market for human use is on the horizon for the research team, Swingle had to start from scratch to make this work possible. She first had to lay the groundwork to run experiments using pregnant mice and determine how to induce pre-eclampsia in this animal model, processes that are not as well studied.
But, by laying this groundwork, Swingle’s work has not only identified an avenue for curing pre-eclampsia, it also opens doors for research on LNP-mRNA therapeutics addressing other reproductive health challenges...
As Swingle thinks ahead for next steps in her research, which was funded by the National Institutes of Health and the National Science Foundation, she will also collaborate to further optimize the LNP to deliver the mRNA even more efficiently, as well as understanding the mechanisms of how it gets to the placenta, a question still not fully answered.
They are already in talks about creating a spin-off company and want to work on bringing this LNP-mRNA therapeutic to clinical trials and the market.
Swingle, who is currently finishing up her Ph.D. research, has not only successfully led this new series of studies advancing pre-eclampsia treatment at Penn, she has also inspired other early career researchers in the field as she continues to thrive while bringing women’s health into the spotlight."
-via Good News Network, December 15, 2024
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ADD SHOP E RETAIL LTD ने Rampur में आयोजित किया 'Organic Farming & Business Opportunities' Seminar
ADD SHOP E RETAIL LTD ने The Opal Hotel (Rampur) में एक विशेष सेमिनार का आयोजन किया, जिसका मुख्य फोकस ‘Organic Farming & Business Opportunities’ पर था। इस दौरान Team Sankalp के Founder Mr. Deepak Kumar Singh खासतौर पर मौजूद रहे। यह सेमिनार Team Sankalp, Rampur द्वारा आयोजित किया गया। सेमिनार की शुरुआत Team Sankalp के Team Leader, Mr. K.P. Singh ने होस्टिंग के साथ हुई। उन्होंने सभी…
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