#mrnp

[orofeaiel]

Paradise Inn - MRNP

[akayna]

Enjoy ten seconds of waterfall

[seabeck]

MRNP

[frommylimitedtravels]

Wandering around the backside of the Tatoosh Range - MRNP

[ribosome-papers]

Two germ granule eIF4E isoforms reside in different mRNPs to hand off C elegans mRNAs from translational repression to activation

bioRxiv: http://dlvr.it/T7RHNr

[rnomics]

Modulation of #RNA binding properties of the #RNA helicase UPF1 by its activator UPF2 [Report]

The NMD helicase UPF1 is a prototype of the superfamily 1 (SF1) of RNA helicases that bind RNA with high affinity and translocate on it in an ATP-dependent manner. Previous studies showed that UPF1 has a low basal catalytic activity that is greatly enhanced upon binding of its interaction partner, UPF2. Activation of UPF1 by UPF2 entails a large conformational change that switches the helicase from an RNA-clamping mode to an RNA-unwinding mode. The ability of UPF1 to bind RNA was expected to be unaffected by this activation mechanism. Here we show, using a combination of biochemical and biophysical methods, that binding of UPF2 to UPF1 drastically reduces the affinity of UPF1 for RNA, leading to a release of the bound RNA. Although UPF2 is capable of binding RNA in vitro, our results suggest that dissociation of the UPF1-RNA complex is not a consequence of direct competition in RNA binding but rather an allosteric effect that is likely mediated by the conformational change in UPF1 that is induced upon binding its activator. We discuss these results in light of transient interactions forged during mRNP assembly, particularly in the UPF1-dependent mRNA decay pathways. http://rnajournal.cshlp.org/cgi/content/short/rna.079188.122v1?rss=1&utm_source=dlvr.it&utm_medium=tumblr

[guidedsailor]

Rainy Days in the Park

[jenifir-juniper]

The best hike ever

[mountrainiernps]

We don’t know about you, but we’re feeling 122!

On this day in 1899, Mount Rainier National Park was established—17 years before the National Park Service came to be. That’s 122 years of recreation, record setting snowfall, research, resource protection, and refuge from our day-to-day lives. The last 122 years have been filled with adventure, and we can’t wait for what the next 100 years has in store for us!

What’s your favorite adventure at Mount Rainier National Park?

NPS/E. Brouwer photo at Sunrise in July 2014. A dirt path leads into a green meadow with trees and wildflowers. Mount Rainier rises from the horizon in the background. -cm

[orofeaiel]

Twisty Mountain Road

[akayna]

Waterfalls on the Paradise side of Mt. Rainier National Park (Tahoma)

Myrtle - Christine - Narada

August 2024

[pattatie]

Mount Rainier National Park | Fall Palette by NatureNan2018 Stopping along a meadow trail to admire fall's palette of color, design and texture. https://flic.kr/p/2jPoo5v

[seabeck]

MRNP

[ibraphotog]

I miss living right outside a national park.

[ch-ak]

Buddy had the best view in the house that day.

[babu31world]

An Oldie But Goody by Stephanie Sinclair Via Flickr: Since today is #tbt here is one from my beginner years that my brother asked about last night. I found it in a data card and reprocessed it to order a metal print for him. I still love this shot and recall the morning I took it, as I was the only one at the lake and had the area to myself. What a gift. #ThrowbackThursday