#mediation service United Kingdom

[brookstonalmanac]

Events 5.13 (before 1955)

1373 – Julian of Norwich has visions of Jesus while suffering from a life-threatening illness, visions which are later described and interpreted in her book Revelations of Divine Love. 1501 – Amerigo Vespucci, this time under Portuguese flag, set sail for western lands. 1568 – Mary Queen of Scots is defeated at the Battle of Langside, part of the civil war between Queen Mary and the supporters of her son, James VI. 1612 – Sword duel between Miyamoto Musashi and Sasaki Kojiro on the shores of Ganryū Island. Kojiro dies at the end. 1619 – Dutch statesman Johan van Oldenbarnevelt is executed in The Hague after being convicted of treason. 1654 – A Venetian fleet under Admiral Cort Adeler breaks through a line of galleys and defeats the Turkish navy. 1779 – War of the Bavarian Succession: Russian and French mediators at the Congress of Teschen negotiate an end to the war. In the agreement Austria receives the part of its territory that was taken from it (the Innviertel). 1780 – The Cumberland Compact is signed by leaders of the settlers in the Cumberland River area of what would become the U.S. state of Tennessee, providing for democratic government and a formal system of justice. 1804 – Forces sent by Yusuf Karamanli of Tripoli to retake Derna from the Americans attack the city. 1830 – Ecuador gains its independence from Gran Colombia. 1846 – Mexican–American War: The United States declares war on the Federal Republic of Mexico following a dispute over the American annexation of the Republic of Texas and a Mexican military incursion. 1861 – American Civil War: Queen Victoria of the United Kingdom issues a "proclamation of neutrality" which recognizes the Confederacy as having belligerent rights. 1861 – The Great Comet of 1861 is discovered by John Tebbutt of Windsor, New South Wales, Australia. 1861 – Pakistan's (then a part of British India) first railway line opens, from Karachi to Kotri. 1862 – The USS Planter, a steamer and gunship, steals through Confederate lines and is passed to the Union, by a southern slave, Robert Smalls, who later was officially appointed as captain, becoming the first black man to command a United States ship. 1888 – With the passage of the Lei Áurea ("Golden Law"), the Empire of Brazil abolishes slavery. 1909 – The first edition of the Giro d'Italia, a long-distance multiple-stage bicycle race, began in Milan; the Italian cyclist Luigi Ganna was the eventual winner. 1912 – The Royal Flying Corps, the forerunner of the Royal Air Force, is established in the United Kingdom. 1917 – Three children report the first apparition of Our Lady of Fátima in Fátima, Portugal. 1940 – World War II: Germany's conquest of France begins, as the German army crosses the Meuse. Winston Churchill makes his "blood, toil, tears, and sweat" speech to the House of Commons. 1941 – World War II: Yugoslav royal colonel Dragoljub Mihailović starts fighting against German occupation troops, beginning the Serbian resistance. 1943 – World War II: Operations Vulcan and Strike force the surrender of the last Axis troops in Tunisia. 1945 – World War II: Yevgeny Khaldei's photograph Raising a Flag over the Reichstag is published in Ogonyok magazine. 1948 – Arab–Israeli War: The Kfar Etzion massacre occurs, a day prior to the Israeli Declaration of Independence. 1950 – The inaugural Formula One World Championship race takes place at Silverstone Circuit. The race was won by Giuseppe Farina, who would go on to become the inaugural champion that year. 1951 – The 400th anniversary of the founding of the National University of San Marcos is commemorated by the opening of the first large-capacity stadium in Peru. 1952 – The Rajya Sabha, the upper house of the Parliament of India, holds its first sitting. 1954 – The anti-National Service Riots, by Chinese middle school students in Singapore, take place.

[mightyflamethrower]

Authored by Marina Zhang via The Epoch Times (emphasis ours),

A new review suggests that COVID vaccines "may trigger" rheumatic immune-mediated inflammatory diseases, including arthritis, vasculitis, lupus, and adult-onset Still's disease.

On average, patients developed rheumatic diseases 11 days after vaccine administration, according to the study. Seventy-five (over 27 percent) of these patients experienced total disease remission, and about 50 percent improved following treatment. Eight were admitted to intensive care, and two died from their symptoms.

"The short time span between COVID-19 vaccine administration and the onset of R-IMIDs suggests the potential possibility of a cause-and-effect relationship," the authors wrote.

Rheumatic immune-mediated inflammatory diseases (R-IMIDs) involve inflammation that manifests in the joints, tendons, muscles, and bones due to an unknown cause.

The study, led by researchers from the National Health Service in the United Kingdom, examined 271 participants from 190 case studies published worldwide.

Over 80 percent of the patients developed symptoms after their first or second dose of the COVID-19 vaccine, and most were treated and improved with corticosteroids.

Almost 57 percent of the injured patients received the Pfizer vaccine, nearly a quarter received the AstraZeneca vaccine, and 12 percent of the rheumatic diseases manifested after the administration of the Moderna vaccine.

Reported Diseases

Rheumatic diseases may be less common than myocarditis, a known adverse event of COVID vaccination. A search on the Vaccine Adverse Event Reporting System (VAERS) found that over 3,000 cases of myocarditis have been reported after the COVID-19 vaccine, with over 2,300 cases of arthritis, over 370 cases of systemic lupus erythematosus, the most common type of lupus, and 280 cases of vasculitis. The following are rheumatic diseases that were included in this first-ever systematic review of new-onset R-MIDs after COVID vaccination.

Inflammation of Blood Vessels

Vasculitis was the most common rheumatic disease in the review, with 86 adverse events recorded. The more common vasculitis diseases affect the smaller blood vessels, causing red spots and lumps on the skin and possible organ damage. Medium and larger blood vessels can also be affected, causing tissue, muscle, and kidney damage.

One patient with inflammation in the larger blood vessels presented with fluid buildup in her lungs. Another developed inflammation in the arteries in his head and lost vision in his left eye due to reduced blood flow to his optical nerves.

Connective Tissue Diseases

Sixty-six cases of diseases affected the connective tissues. Diseases that fall under this category include lupus, an autoimmune disease affecting the skin, joints, and internal organs, and myositis and dermatomyositis, which manifest as muscle and tissue inflammation.

Two patients died of their conditions. One was a 44-year-old man who developed myositis, or muscle inflammation, and compartment syndrome in his limbs. Compartment syndrome is a painful and potentially fatal condition where pressure in muscles builds up. Another 62-year-old female died after developing diabetes and dermatomyositis, inflammation of both the skin and muscles, after getting the Pfizer vaccine.

Arthritis

Fifty-five patients developed arthritis after taking the vaccine, primarily manifesting in the knees, elbows, and ankles.

After treatment with steroids, most experienced some improvement in their symptoms, 12 went into remission, and two had persistent symptoms.

Adult-Onset Still's Disease

Twenty-two cases of adult-onset Still's disease were documented in the report. Symptoms of this rare disease include daily fever, arthritis in more than five joints, and salmon-pink rashes on the body. Six of these patients also developed cardiac problems, two of whom developed myocarditis and heart failure.

Five of the patients went into remission, while most experienced improvement in their conditions after being treated with steroids.

Other Diseases

Less common diseases include polymyalgia rheumatica, reported in 21 people. Symptoms of this disease include stiffness and inflammation in the shoulders, neck, and hips, and sarcoidosis, which occurs when inflamed tissues start to grow inside organs, causing tissue malfunction.

Molecular Mimicry Is the Leading Explanation

The authors noted the very short duration between vaccination and symptom onset, with 11 days being the average duration. This duration is similar to those found in other studies investigating myocarditis side effects after COVID-19 vaccines. The authors reasoned that the vaccine may have been a "trigger" for the rheumatoid diseases.

However, some of the patients might have been predisposed to rheumatic diseases, the authors reasoned. Additionally, some might have been predisposed to having a highly inflammatory response to mRNA vaccinations, leading to rheumatic symptoms like joint stiffness and inflammation.

Molecular mimicry, which occurs when the body mistakes foreign substances for its own and mounts an immune response, is the leading explanation for the development of these autoimmune diseases. The authors reasoned that vaccine adjuvants like aluminum may be structurally similar to human proteins. Therefore, the body might have mistaken self-tissue while attacking these adjuvants, perceived as foreign invaders.

However, many studies have shown that the spike proteins on the surface of the COVID-19 virus share structural similarities to human proteins. One study found that antibodies that reacted to spike protein could also react to nearly 30 different human tissues. If the spike proteins induced by the COVID-19 vaccines are similar to the original viral spike proteins, then the vaccine spike proteins may also trigger autoimmunity.

Another possibility is that mRNA vaccines may trigger the formation of inflammasomes. Inflammasomes are clusters of proteins that signal inflammation and viral elimination. This can also cause immune cells to become hyperactive and damage self-tissues in an attempt to clear the vaccine.

THIS is exactly what happened to me. I have RA and haven't felt good two days in a row since I took the JAB. Both shots made me very sick. After the second one my heart beat exhilarated to 130-140 BPM.

They had to crack my chest in order to slow my heart down and restore circulation to the upper chambers of my heart (myocardia). Six months after that my appendix died and went to gangrene before it ruptured. Right now my kidneys have only 55 percent function. I hope the people I leave behind can figure out a way to sue the makers of the Jab. The VA refuses to document it.

[literaturereviewhelp]

The research project involved carrying out an analysis and design of concrete pavements based on a comprehensive literature review as well as on the results of a number of engineering tests to determine the best designs for concrete pavements. Concrete pavements are road surfaces that are built using a concrete mixture of Portland cement, sand, coarse aggregate and water to provide durable surfaces that can effectively sustain vehicular or foot traffic. The history of the use of concrete pavements on roads and walkways dates back to 1893 when the world’s first strip of concrete pavement was successfully completed. According to Croney (2008), the first concrete roads were constructed in the United States at the beginning of the 20th century and the technology later spread to Europe and the other parts of the world in the 1920s. Over the years, concrete as a building material has been increasingly used for paving airports, highways, residential streets as well as business parking lots. According to many experts, the increasing popularity of concrete pavements is particularly attributed to the numerous benefits of using concrete as a paving material some of which include its durability and less maintenance requirement, workability, strength, cost effectiveness and durability. Contemporary design techniques used for concrete pavements have resulted in the development of economically sustainable concrete pavements that are not only offer one of the best riding surfaces but are able to perform for many years with minimal maintenance. According to Horenstein (34), modern designs often take into account all the diverse sorts of environmental conditions including future estimations on environmental changes and traffic growth. Currently, there is a growing need for sustainable and low cost alternative pavement materials in many developed countries including Australia.   or   The overall annual incidence of traumatic brain injury in the United Kingdom is nearly 300/100 000. (British,1998) A majority of the TBI patients are young however their life expectancy is only occasionally diminished, (NHS, 1996; Rimel et al, 1990) this has resulted in a substantial population of TBI victims living in the UK. It has been conjectured that as many as 500 000 people in the United Kingdom may be presently living with the consequences of their head injury. (McMillan &Greenwood 1991). Traumatic brain injury is often "a hidden disability"(Social, 1995) as an affected person may appear physically normal, and as yet may harbor considerable cognitive, psychological, social, emotional, and behavioral problems. While it is a fact that about 2% of the US population suffers from some form of TBI-related disability, as yet no known holistic pharmacological treatment is currently available. As a result TBI progressively causes post-acute injury, progressive neuronal degeneration occasioned by acute and delayed cell death mediated in part by calpains (Kampfl et al. 1996) and in part by apoptotic-inducing caspases (Rink et al. 1995; Colicos et al. 1996; Yakovlev et al. 1997; Conti et al. 1998; Newcomb et al. 1999; Clark et al. 2000).Thus psychosocial problems, in particular, have been documented long after discharge from acute services. These include impaired judgment, short temper, aggression, and intolerance of others. (McKinlay et al,1981; Tate et al,1981; Thomsen ,1992; Koskinen,1998) The long-term or permanent effects of brain injury may require post-injury and possibly life-long rehabilitation. Such effects include: cognitive deficits-coma, confusion, shortened attention span, memory problems and amnesia, problem-solving deficits, problems with judgment, inability to understand abstract concepts, loss of sense of time and space, decreased awareness of self and others, inability to accept more than one- or two-step commands simultaneously; motor deficits- paralysis or weakness, spasticity (tightening and shortening of the muscles), poor balance decreased endurance, inability to plan motor movements, delays in initiation. Read the full article

[head-post]

US, Russia to meet in Saudi Arabia over Ukraine crisis

A US-Russian meeting on Ukraine in Saudi Arabia is due to take place on Tuesday, Axios  reported, citing informed sources.

Russian and US delegations are already in Saudi Arabia

“A meeting of senior US and Russian officials to discuss a possible agreement to end the conflict in Ukraine and prepare for a summit between Trump and Putin will take place in Saudi Arabia on Tuesday, two informed sources said,” the media said.

They confirmed media reports that the US side will be represented by Secretary of State Marco Rubio, National Security Adviser to the President Mike Walz and Special Representative for the Middle East Steve Whitkoff.

On the Russian side, several key figures will take part in the talks. Among them are presidential aide Yuri Ushakov, Foreign Intelligence Service director Sergei Naryshkin and Kirill Dmitriev, head of the Russian Direct Investment Fund. These high-profile diplomats and specialists will actively participate in the discussion and elaboration of possible solutions that could help stabilise the situation in Ukraine and the international arena as a whole.

Saudi Arabia, as it has become known, is not just providing its territory for these important meetings, but will also assume the role of a mediator in the negotiation process. This decision seems to be driven by the kingdom’s desire to strengthen its position in the international arena and play an important role in resolving one of the most pressing conflicts in Europe. At the talks, the Saudi delegation will be headed by the kingdom’s national security adviser, which emphasises the importance of this event for the country.

Ukraine is not invited to the negotiations

The Ukrainian delegation has actively started its work in Saudi Arabia. TV channel NBC, citing sources, reported that Ukraine’s participation in the meeting in Saudi Arabia is not envisaged.

“Two US officials confirmed that Ukraine was not invited to the talks in Saudi Arabia, but said that the United States intends to hold a bilateral meeting with Russia, then a bilateral meeting with Ukraine, and after that – joint talks,” NBC reported.

However, US President Donald Trump confirmed the participation of Ukrainian President Volodymyr Zelensky in the negotiation process.

“He will be involved, yes,” he said, speaking to reporters.

Zelensky to travel to Saudi Arabia

Zelensky is preparing to travel to Saudi Arabia, where talks between Russian and US Presidents Vladimir Putin and Donald Trump may take place. Ukrainian Economy Minister Yulia Svyrydenko said that as part of the visit, the Ukrainian leader had scheduled meetings with local entrepreneurs to discuss initiatives in the spheres of energy, agriculture and infrastructure. According to her, the Ukrainian delegation is already in the kingdom.

Zelensky said that he was ready to hold talks with Putin, provided that representatives of the US and Europe were present and there were “strong security guarantees.” In an interview with NBC, he also noted that it is impossible to end the conflict without the decision of the Russian leader.

Zelensky stated the need to meet with the US president. He also noted that Trump did not invite him to Saudi Arabia, although he is ready to meet in Washington. Zelensky emphasised that the teams of both presidents need to agree on details to set a date for the meeting.

He also noted that Ukraine would not accept a deal between the US and Russia to resolve the conflict without taking its opinion into account and added that the US most likely does not have a clear peace plan for Ukraine. In addition, Zelensky said he was working on a co-operation agreement to attract US investment in Ukraine. He also stated his desire to show the “front lines” to Trump’s special representative Keith Kellogg during his visit to Kyiv.

US-Russia contacts

Meanwhile, Rubio had his first phone conversation with Russian Foreign Minister Sergey Lavrov on the evening of February 15. According to the Russian Foreign Ministry, they agreed to maintain a channel of communication to solve the accumulated problems in Russian-American relations. In addition, the sides have a “mutual mood” to interact on topical international issues, including the settlement around Ukraine, Palestine and in general in the Middle East and other areas.

In addition, Rubio and Lavrov agreed “in the very near future” to organise a meeting of experts for the subsequent mutual removal of obstacles to the work of the foreign missions of the two countries. Among the examples of tougher conditions for the functioning of Russian diplomatic missions in the US are visa restrictions, expulsion of diplomats, and restrictions on their movement.

UK is “ready” to put troops on ground

News of the talks between the US and Russia came after British Prime Minister Keir Starmer said Sunday that he was ready to deploy British troops to Ukraine to enforce a peace agreement if necessary, CNN reports.

In an article for the Daily Telegraph, Starmer said he does not take the possibility lightly, but believes that helping to secure Ukraine would also strengthen the security of the United Kingdom and Europe.

The British prime minister urged European countries to increase their defence spending and “play a greater role in NATO,” but said US support would still be crucial to ensure peace. Prime Minister Keir Starmer also said he would meet with Trump and other G7 allies in the coming days to strike a favourable deal.

Read more HERE

[swldx]

BBC 0536 18 Jan 2025

7285Khz 0458 18 JAN 2025 - BBC (UNITED KINGDOM) in ENGLISH from ASCENSION ISLAND. SINPO = 35233. English, s/on @0458z with Bowbells int. fb ID, pips and Newsroom preview. @0501z World News anchored by David Harper. § Israel's government has approved the new Gaza ceasefire and hostage release deal with Hamas, paving the way for it to take effect on Sunday. It came hours after the prime minister's office and Hamas both said they had finalised the details of the agreement, two days after it was announced by mediators Qatar, the US and Egypt. § TikTok has said it will be forced to "go dark" in the US on Sunday unless the government intervenes before a ban takes effect. In a statement late on Friday, it said the White House and the Department of Justice had "failed to provide the necessary clarity and assurance to the service providers that are integral to maintaining TikTok's availability". It said that unless the government immediately stepped in to assure the video app it would not be punished for violating the looming ban, it would be "forced to go dark on January 19".§ President-elect Donald Trump's inaugural address on 20 January will take place indoors due to dangerously cold weather being forecast next week in Washington, he has confirmed. The address, as well as other speeches, will now take place inside the US Capitol's rotunda, rather than outside the building. The inaugural parade will also be held indoors at Washington's Capital One Arena in downtown Washington about one mile (1.6km) away, along with all three inaugural balls. The last president to be sworn-in indoors was Ronald Reagan in 1985, when cold weather also plagued the US Capitol. § A massive fire and explosions ripped through an indoor children's park and a casino in the Mexican city of Culiacán on Thursday. A 39-year-old man was rushed to an area hospital for treatment to burns on his hands and back, authorities said. § As 3,000 riot police swarmed his hillside villa on Wednesday, South Korean President Yoon Suk Yeol huddled with party loyalists, telling them that people were increasingly realising the country's legal system had been hijacked by leftist forces. "People are now seeing how serious the situation is," the impeached president told the gathering, according to one lawmaker present, Yoon Sang-hyun. "It starts now," the 64-year-old leader said, according to another lawmaker, Kwon Young-jin. § A Bolivian judge has ordered the arrest of the former president Evo Morales over his alleged abuse of a teenage girl while in office, raising the stakes in the state’s months-long showdown with the former leader. The judge in the southern city of Tarija called for Morales, 65, to be arrested after Bolivia’s first Indigenous president ducked out of a hearing on his possible pre-trial detention for a second time. § Sports. @0506z “The Newsroom” begins. Backyard gutter antenna w/MFJ-1020C active antenna (used as a preamplifier/preselector), JRC NRD-535D, 250kW, beamAz 115°, bearing 103°. Received at Plymouth, United States, 9763KM from transmitter at Ascension Island. Local time: 2325.

[acquaintsofttech]

Robust Laravel Application Development - Lessons Learned

Introduction

Building a robust Laravel application that can scale, handle high traffic, and remain maintainable over time is not without its challenges. Over the years, developers and teams have encountered several common pitfalls and learned invaluable lessons while building and maintaining large-scale Laravel applications.

Developing robust applications with Laravel requires careful planning, attention to detail, and adherence to best practices. It is also essential to have an in-depth understanding of the intricacies of secure and scalable architecture. This would ideally mean trusting a software development outsourcing company like Acquaint Softtech.

This article provides more information on the lessons learned from building robust Laravel applications. It focuses on best practices, common mistakes, and solutions to improve application scalability, security, maintainability, and performance.

Laravel Application Development

Laravel has rapidly become one of the most popular PHP frameworks due to its expressive syntax, rich ecosystem, and developer-friendly features. With Laravel, developers can build modern web applications with ease, thanks to the abundance of built-in tools, comprehensive documentation, and support for modern PHP standards.

It is a powerful PHP framework that offers developers a structured and efficient way to build web applications. There are many reasons why Laravel is the ideal web framework. It has an elegant syntax, follows the MVC architecture, and has a special Blade templating engine.

Besides this, Laravel also eliminates the need to build an authentication system from scratch since it is in-built. The special object-relational mapping, Eloquent CRM helps simplify the database operations.

But that's not all. Not only does Laravel have good features to build a robust solution, but it also has the necessary tools and features to help you test it. Testing, debugging, and validation are highly simplified with Lararel. It allows the use of special test tools like PHPUnit and PEST.

Here are a few interesting statistics:

2706 of the Laravel powered websites are from the Web Development sector. (6sense)

Over 303,718 Americans use Laravel, while this figure is 54,648 in the United Kingdom and 31,053 in Russia. (BuiltWith)

As data collected in 2024, 7.9% of developers use the Laravel framework worldwide while 4.7% use Ruby on Rails, 3.2% use Symfony framework and 1.7% use Codeigniter.

Node.js is one of the most popular with 40.8% using it; React comes close second at 39.5%

Lessons Learned

Understand the MVC Architecture Thoroughly : Lesson 1

Laravel adheres to the Model-View-Controller (MVC) architecture, which separates the application logic from the user interface. This separation is critical for building scalable and maintainable applications. One of the key lessons learned from working with Laravel is that a deep understanding of the MVC architecture is essential for building a robust application.

Model: Represents the data layer and handles business logic.

View: The user interface that the end-user interacts with.

Controller: Mediates between the Model and the View, processing user requests and sending the appropriate response.

A common mistake is allowing business logic to seep into the controller or view. This breaks the MVC pattern, making the application harder to maintain and test. Adhering to strict separation of concerns ensures that each application part can be developed, tested, and maintained independently.

Key Takeaway: Always ensure that business logic resides in models or services, controllers handle user requests, and views strictly present data without containing any application logic.

Use Eloquent ORM Effectively : Lesson 2

Laravel's built-in Object Relational Mapping (ORM) tool (Eloquent) provides a simple and elegant way to interact with the database. However, improper use of Eloquent can lead to performance issues, especially in large applications with complex database queries.

Common Mistakes: N+1 Query Problem: The N+1 problem occurs when a query retrieves a list of items but then executes additional queries to fetch related items for each entry. This can lead to hundreds of unnecessary database queries. To avoid this, Laravel offers the with() method for eager loading relationships.

php code

// Bad

$posts = Post::all();

foreach ($posts as $post) {

echo $post->author->name;

}

// Good (Using eager loading)

$posts = Post::with('author')->get();

foreach ($posts as $post) {

echo $post->author->name;

}

Mass Assignment Vulnerabilities: Laravel's MassAssignment allows you to bulk insert or update data in the database. However, safeguarding against mass assignment can expose your application to vulnerabilities. Developers should always use $fillable or $guarded properties in their models to protect against mass assignment.

php  code

// Protecting against mass assignment

protected $fillable = ['title', 'content', 'author_id'];

Solutions: Always use eager loading to avoid the N+1 problem.

Define fillable attributes to protect against mass assignment.

Avoid complex queries in models. Instead, use Query Builder for more advanced database interactions that Eloquent struggles with.

Key Takeaway: Use Eloquent for simple CRUD operations, but be mindful of performance concerns and security risks. When necessary, fall back on Laravel’s Query Builder for complex queries.

Service Layer for Business Logic : Lesson 3

As Laravel applications grow, keeping controllers slim and models focused on data becomes increasingly important. This is where the service layer comes in. Service classes allow developers to isolate business logic from controllers and models, making the application more modular and easier to test.

Example:

Instead of handling user registration logic in the controller, a service class can be created to handle it.

PHP code

// In the UserController

public function store(UserRequest $request)

{

$this->userService->registerUser($request->all());

}

// In UserService

public function registerUser(array $data)

{

$user = User::create($data);

// Other business logic related to registration

}

This pattern makes it easier to maintain, test, and scale the application as business logic becomes more complex.

Key Takeaway: Introduce a service layer early on for business logic to improve code organization and maintainability.

Prioritize Security at Every Step : Lesson 4

Security is a fundamental aspect of building a robust Laravel application. One of the lessons learned from years of Laravel development is that security should not be an afterthought. Laravel provides many built-in security features, but it’s up to developers to use them correctly.

Key Security Practices:

Sanitize Input: Always sanitize user inputs to prevent XSS (Cross-Site Scripting) and SQL injection attacks. Laravel automatically escapes output in Blade templates, which helps protect against XSS. For SQL injection protection, always use Eloquent or Query Builder.

Use CSRF Protection: Laravel automatically protects against Cross-Site Request Forgery (CSRF) by including a CSRF token in forms. Developers must ensure that CSRF protection is not disabled unintentionally.

Authentication and Authorization: Laravel offers built-in authentication and authorization mechanisms through policies, gates, and middleware. Use them to control access to resources and ensure users have the necessary permissions.

Password Hashing: Always store user passwords using Laravel’s Hash facade, which uses bcrypt by default. Avoid storing plain-text passwords in the database.

PHP

$user->password = Hash::make($request->password);

Rate Limiting: To prevent brute force attacks, implement rate limiting using Laravel’s RateLimiter facade.

Secure API Development: When building APIs, use OAuth2 or Laravel Sanctum for token-based authentication. Also, rate limiting for API endpoints should be implemented to prevent abuse.

Key Takeaway: Leverage Laravel's built-in security features and be proactive in identifying potential vulnerabilities.

Lesson 5: Cache Strategically for Performance

Caching is critical for improving the performance of Laravel applications, especially as they scale. Laravel supports various caching mechanisms, including file, database, Redis, and Memcached.

Best Practices for Caching:

Cache Expensive Queries: If your application frequently runs heavy queries, consider caching the results to reduce the load on the database.

PHP code

$users = Cache::remember('users', 60, function () {

return User::all();

});

Route Caching: Laravel provides a route:cache Artisan command to cache all routes in your application. This can significantly improve the performance of larger applications.

Bash CODE

php artisan route:cache

View Caching: Similarly, views can be cached to avoid unnecessary recompilation.

Bash CODE

php artisan view:cache

Optimize Configuration Loading: Use config:cache to combine all configuration files into a single file, reducing the time it takes to load configurations during requests.

bash CODE

php artisan config:cache

Key Takeaway: Use caching strategically to optimize performance and reduce server load, especially for database-heavy applications.

Optimize Database Interactions : Lesson 6

Efficient database interaction is critical for building scalable Laravel applications. Poorly optimized queries or over-reliance on ORM abstractions can lead to performance bottlenecks.

Best Practices for Database Optimization:

Database Indexing: Ensure that frequently queried columns are indexed. Laravel’s migration system supports creating indexes with ease.

php code

Schema::table('users', function (Blueprint $table) {

$table->index('email');

});

Avoid SELECT * Queries: Always specify the columns you need in a query. Fetching all columns unnecessarily increases the load on the database and memory usage.

php  code

$users = User::select('id', 'name', 'email')->get();

Use Pagination: For large datasets, always paginate results rather than fetching everything at once.

php code

$users = User::paginate(15);

Database Query Profiling: Use Laravel’s built-in query log to identify slow queries. You can enable query logging with the following code:

php code

DB::enableQueryLog();

Key Takeaway: Optimize database queries by using indexes, avoiding unnecessary data fetching, and employing efficient pagination techniques.

Test Your Application : Lesson 7

Testing is a crucial aspect of robust Laravel application development. Laravel comes with PHPUnit integration, making it easy to write unit tests, feature tests, and browser tests. However, many developers tend to skip or neglect testing due to time constraints, which often leads to bugs and regressions.

Testing Best Practices:

Unit Tests: Unit tests focus on testing individual components or methods. They are fast and reliable but don’t cover the whole application flow.

php code

public function testUserCreation()

{

$user = User::factory()->create();

$this->assertDatabaseHas('users', ['email' => $user->email]);

}

Feature Tests: Feature tests allow you to test the entire application flow, from requests to responses. They ensure that the application behaves as expected in real-world scenarios.

php  code

public function testUserRegistration()

{

$response = $this->post('/register', [

'name' => 'John Doe',

'email' => 'john@example.com',

'password' => 'secret',

'password_confirmation' => 'secret',

]);

$response->assertStatus(302);

$this->assertDatabaseHas('users', ['email' => 'john@example.com']);

}

Continuous Integration: Integrate automated tests with a continuous integration (CI) tool such as GitHub Actions or Travis CI. This ensures that your tests are automatically run whenever new code is pushed, preventing broken code from being deployed.

Key Takeaway: Always write tests for critical application components and workflows to ensure stability and reliability.

Prioritize Code Maintainability and Readability : Lesson 8

Laravel is known for its elegant syntax and developer-friendly structure, but as the application grows, maintaining clean and readable code becomes challenging.

Best Practices for Maintainability:

Follow PSR Standards: Laravel encourages following the PHP-FIG’s PSR standards, such as PSR-2 for coding style and PSR-4 for autoloading. Following these standards ensures that your codebase remains consistent and easy to navigate.

Use Named Routes: Using named routes instead of hard-coded URLs makes it easier to manage changes in the URL structure.

php code

Route::get('/user/profile', 'UserProfileController@show')->name('profile');

Refactor Regularly: As the application evolves, refactor code regularly to avoid technical debt. Use Laravel’s php artisan make:command to create custom Artisan commands that automate repetitive tasks.

Comment and Document: Clear comments and documentation help other developers (or even yourself in the future) understand the purpose of the code. Use Laravel’s DocBlocks to document classes, methods, and variables.

Key Takeaway: Invest in code quality by following coding standards, refactoring regularly, and documenting thoroughly.

Leverage Laravel’s Ecosystem : Lesson 9

Laravel has an extensive ecosystem that can simplify development and add powerful features to your application. Leveraging this ecosystem can save Laravel application development time and reduce complexity.

Key Laravel Tools and Packages:

Laravel Horizon: Provides a dashboard and tools to monitor queues and jobs in real-time.

Laravel Echo: Integrates WebSockets and real-time broadcasting capabilities into Laravel applications.

Laravel Telescope: A debugging assistant that allows you to monitor requests, queries, exceptions, logs, and more.

Laravel Sanctum: API authentication using tokens is especially useful for single-page applications (SPAs).

Laravel Vapor: A serverless deployment platform for Laravel that enables you to deploy Laravel applications on AWS Lambda without managing infrastructure.

Key Takeaway: Use Laravel’s ecosystem of tools and packages to extend your application’s capabilities and streamline development.

Prepare for Scalability : Lesson 10

As your Laravel application grows, you need to ensure that it can scale to handle increased traffic and data.

Key Scalability Considerations:

Horizontally Scale Your Database: As your user base grows, consider using database replication to scale horizontally. Laravel supports multiple database connections and read-write splitting.

Use Job Queues: Offload time-consuming tasks (such as sending emails or processing files) to queues. Laravel’s queue system supports drivers like Redis, Beanstalkd, and Amazon SQS.

Optimize Load Balancing: For high-traffic applications, consider using a load balancer to distribute incoming traffic across multiple application servers.

Containerization: Use Docker to containerize your Laravel application. Containerization ensures that your application can run consistently across various environments and can be scaled easily using orchestration tools like Kubernetes.

Key Takeaway: Plan for scalability from the start by using job queues, load balancing, and database replication.

Use Configuration and Environment Management Properly : Lesson 11

Lesson: Mismanaged environment configurations can lead to security and stability issues.

Practice: Store sensitive configurations like database credentials, API keys, and service configurations in .env files. Utilize Laravel’s configuration caching (config:cache) for production environments.

Tip: Regularly audit .env files and restrict sensitive data from being logged or committed to version control.

Some of the other lessons learned from developing a robust Laravel solution include that it has Artisan. This allows one to use a command line tool, Artisan, that can automate repetitive tasks. This serves the purpose of accelerating the development process. It is possible to simplify the process of managing the packages with the help of 'Composer'. API development is a breeze with Laravel since it has in-built support for RESTful APIs.

Benefits Of A Robust Laravel Solution

A robust Laravel solution offers a multitude of benefits for businesses and developers, ranging from enhanced security and scalability to faster development and easier maintenance.

Hire remote developers from Acquaint Softtech to build a top-notch solution. We have over 10 years of experience developing cutting-edge solutions.

Here's a detailed look at the key benefits of using a robust Laravel solution:

Scalability and Performance Optimization

Enhanced Security Features

Faster Time to Market

Modular and Maintainable Codebase

Seamless API Integration

Efficient Database Management

Simplified User Authentication and Authorization

Robust Testing Capabilities

Efficient Task Scheduling and Background Processing

Vibrant Community and Ecosystem

Advanced Caching Mechanisms

Support for Multilingual and Multi-tenant Applications

Built-in Tools for SEO and Content Management

Conclusion

Building a robust Laravel application requires a deep understanding of best practices, design patterns, and the ability to anticipate challenges. By learning from the lessons shared above, developers can avoid common pitfalls and ensure that their applications are secure, performant, maintainable, and scalable. Following these guidelines not only enhances the quality of the code but also helps deliver applications that stand the test of time

Analyzing case studies of successful Laravel applications can provide a roadmap for best practices and strategies. At the same time, these lessons learned from developing a robust, scalable, and secure Laravel application are also of great value.

[qocsuing]

The Importance of Forex Regulatory Bodies

The Importance of Forex Regulatory Bodies The foreign exchange (forex) market is the largest and most liquid financial market in the world, with daily trading volumes exceeding $6 trillion. Given its size and decentralized nature, the forex market is susceptible to various risks, including fraud, manipulation, and unethical practices. This is where forex regulatory bodies play a crucial role. These organizations are responsible for overseeing and regulating the forex market to ensure its integrity, transparency, and fairness. This article explores the importance of forex regulatory bodies and their impact on the market.To get more news about forex regulatory, you can visit our official website.

Ensuring Market Integrity One of the primary functions of forex regulatory bodies is to maintain market integrity. They achieve this by setting and enforcing rules and standards that all market participants must follow. These regulations help prevent fraudulent activities, such as price manipulation and insider trading, which can undermine the trust and stability of the market. For instance, the U.S. Commodity Futures Trading Commission (CFTC) and the National Futures Association (NFA) are responsible for regulating forex trading in the United States, ensuring that brokers and traders adhere to strict ethical standards.

Protecting Investors Investor protection is another critical aspect of forex regulation. Regulatory bodies implement measures to safeguard retail traders from unscrupulous brokers and fraudulent schemes. This includes requiring brokers to be licensed and registered, conducting regular audits, and ensuring that they maintain adequate capital reserves. In the European Union, the European Securities and Markets Authority (ESMA) has introduced stringent regulations to protect investors, such as leverage limits and negative balance protection. These measures help create a safer trading environment for retail investors.

Promoting Transparency Transparency is essential for the proper functioning of the forex market. Regulatory bodies promote transparency by requiring brokers to provide clear and accurate information about their services, fees, and trading conditions. This allows traders to make informed decisions and compare different brokers effectively. For example, the Financial Conduct Authority (FCA) in the United Kingdom mandates that brokers disclose their financial statements and any conflicts of interest. Such transparency helps build trust between brokers and traders, fostering a more reliable market.

Enhancing Market Stability Forex regulatory bodies also play a vital role in enhancing market stability. By monitoring and supervising the activities of market participants, they can identify and address potential risks before they escalate. This proactive approach helps prevent systemic issues that could disrupt the market. The Australian Securities and Investments Commission (ASIC), for instance, closely monitors the financial health of brokers and takes corrective actions when necessary to ensure market stability.

Facilitating Dispute Resolution Disputes between traders and brokers are inevitable in the forex market. Regulatory bodies provide mechanisms for resolving these disputes fairly and efficiently. They offer mediation and arbitration services to help parties reach amicable solutions without resorting to lengthy and costly legal proceedings. The Cyprus Securities and Exchange Commission (CySEC) is known for its effective dispute resolution framework, which has helped resolve numerous conflicts between traders and brokers.

Adapting to Technological Advancements The forex market is constantly evolving, driven by technological advancements and changing market dynamics. Regulatory bodies must adapt to these changes to remain effective. This includes updating regulations to address new trading technologies, such as algorithmic trading and cryptocurrencies. By staying ahead of technological trends, regulatory bodies can continue to protect market participants and ensure the market’s integrity. The Monetary Authority of Singapore (MAS) is a prime example of a regulator that has embraced innovation while maintaining robust oversight.

Conclusion In conclusion, forex regulatory bodies are indispensable for the proper functioning of the forex market. They ensure market integrity, protect investors, promote transparency, enhance market stability, facilitate dispute resolution, and adapt to technological advancements. Without these regulatory bodies, the forex market would be vulnerable to fraud, manipulation, and systemic risks. Therefore, it is essential for traders to understand the role of these organizations and choose brokers that are regulated by reputable authorities. By doing so, they can trade with confidence and contribute to a fair and transparent forex market.

[thxnews]

Quad Leaders Urge Gaza Ceasefire

With a significant move amid the 80th anniversary of the D-Day landings, the leaders of the United Kingdom, the United States, Germany, and France have issued a unified statement on the escalating situation in Gaza. On June 6, 2024, they emphasized their backing for President Biden's comprehensive deal aimed at halting hostilities and promoting lasting peace in the region.  

A Call for Immediate Action

The Quad Leaders—Rishi Sunak, Joe Biden, Olaf Scholz, and Emmanuel Macron—have called for an immediate ceasefire in Gaza. Their joint statement underscores the urgent need to end the violence, release hostages, and significantly increase humanitarian aid to alleviate the suffering of civilians.  

El Baba Children collect water in Khan Younis city, in the southern Gaza Strip. Photo by Eyad. UNICEF.   Key Elements of the Statement - Immediate Ceasefire and Hostage Release: The leaders stress the necessity of an immediate halt to all hostilities and the release of all hostages. - Humanitarian Assistance: A substantial increase in humanitarian aid is essential, including the provision of temporary shelters, medical facilities, and food supplies. - Infrastructure Rehabilitation: Immediate refurbishment of essential services such as electricity, water, and medical facilities is crucial for stabilizing the region.  

Support for Long-term Solutions

The statement not only addresses the immediate crisis but also emphasizes long-term solutions. The leaders reaffirm their commitment to a two-state solution as the only viable path to lasting peace and security for both Israelis and Palestinians.   Commitment to Israel's Security Reiterating their unwavering support for Israel's security, the Quad Leaders call for Hamas to fully accept the proposed comprehensive deal. They emphasize that this proposal, agreed upon by Israel, should be implemented without delay to bring an enduring end to the conflict.  

Backing the Palestinian Authority

The leaders also expressed strong support for the Palestinian Authority and Prime Minister Mohammed Mustafa's reform program. They call for increased regional and international backing for the Palestinian government, including the transfer of revenues by Israel.   Restoring Governance in Gaza A significant part of the leaders' statement focuses on the need to restore legitimate Palestinian governance in Gaza. This requires appropriate international support and addresses Israel's security concerns. The leaders commit to contributing to international stabilization efforts in Gaza, aiming for long-term regional security and preventing future crises.  

Gaza Strip after the ceasefire. Photo by Samar Abu Elouf. Wikimedia.  

Preserving Stability in Lebanon

The Quad Leaders also highlight the importance of maintaining stability in Lebanon. They urge all parties to exercise maximum restraint to avoid further regional escalation and stress their determination to support de-escalation efforts consistent with UN Security Council Resolution 1701.  

International Coordination and Efforts

The leaders stress the need for coordinated international efforts to implement President Biden's proposed deal. This includes ensuring the efficient delivery of humanitarian aid and supporting mediation efforts to achieve regional peace and stability.  

Key Points of the Quad Leaders' Statement

Aspect Details Ceasefire Immediate cessation of hostilities and release of hostages Humanitarian Assistance Significant increase in aid, including shelters and medical facilities Infrastructure Rehabilitation Refurbishment of essential services like electricity, water, and medical facilities Long-term Peace Commitment to a negotiated two-state solution Israel's Security Emphasis on the need for Hamas to accept the comprehensive deal Palestinian Authority Support Backing Prime Minister Mustafa's reform program and increasing international support Governance in Gaza Restoration of legitimate Palestinian governance with international support Lebanon Stability Importance of stability and support for de-escalation efforts International Coordination Ensuring efficient delivery of aid and supporting mediation efforts  

RAF Humanitarian aid delivery in Gaza. Photo by the Ministry of Defence. Gov.uk.  

What it Means

The Quad Leaders' statement reflects a strong, unified approach to addressing the crisis in Gaza. By supporting President Biden's comprehensive deal, they aim to bring immediate relief to civilians, ensure long-term peace and security, and prevent future conflicts. Their commitment to a two-state solution, Israel's security, and the restoration of governance in Gaza underscores their dedication to a stable and peaceful Middle East.   Sources: THX News, Prime Minister's Office, 10 Downing Street & The Rt Hon Rishi Sunak. Read the full article

[adventism-atheism-orthodoxy-me]

The Invisible Hand

Back in the late 1700's a man by the name of Adam Smith in a book he wrote entitled, the Wealth of Nations, gave a name, "The Invisible Hand", to a system, a god, that had existed since the dawn of time. Known imperfectly throughout history, mankind still benefited from this god's benevolence every time goods and services exchanged hands peaceably, rather than through war, violence and coercion. First sheaves of wheat could be traded for clay pots, or barrels of fish; later these same sheaves of wheat could be traded for currency, which didn't depend upon the particular needs of potters or fishmongers to determine value. Every time something is, has, or will ever be traded, this god's activities are made manifest.

However, like every system on earth, as soon as man realized that he could exploit it, distortions resulted from this exploitation. In Ancient Rome, "Bread and Circuses", became the way a ruler could distract his people from problems that plagued their everyday existence. It was a market trade-off in distraction, but at some point the cost of maintaining the expense of these distractions could no longer be maintained, and the Empire that used these tactics fell into disarray and dissolution.

We currently live in a society that has raised this "Invisible Hand" to heights unprecedented in history. We have sects with their own priesthoods: Capitalists advocate for completely unmediated restraints on market manipulation, while Communists advocate for total restraint, with only government manipulation allowed. None of this is seen to be mediated in any way by an even higher power, by none other than God who established these processes and mechanisms that would enable us to engage with one another peaceably.

I remember the first time I heard, "Greed is good", I thought to myself that it was an oversimplification of a very complex issue. Maybe fine for a bumper sticker, but certainly not something anyone would take seriously. Enlightened self interest does lead to good outcomes. Every creature in the animal kingdom seeks to avoid pain and death, and seeks to acquire food and shelter. That greed could be seen as the greatest good, a moral absolute in it's own right, unmediated by the grace of God who made this gift possible seemed bizarre. What's really disheartening is hearing Christians passionately argue that Capitalism is God given in the same sense as God IS Capitalism.

To suppress the invisible hand is to deny reality. Many communes, and even countries have tried to find a better way to produce and distribute goods and services to those who need them outside of using the principles outlined by Adam Smith. These societies almost universally fall apart because of unmitigated human selfishness. They are frequently run by authoritarian leaders, and are characterized by rampant slothfulness, and hording. Inflation in the Soviet Union could be measured by the length of lines that formed for the acquisition of goods. Rather than exchanging time for productive work that produced a product and a wage that could be used to purchase a good or service; time was spent in a line, producing nothing.

The Invisible Hand is a God given creation, it cannot be denied, but must be constrained by the "Good God, who loves mankind".

Much of modern intelligentsia loves to blame the modern American "Consumer Culture" for the ills in our society. The problem with that assertion is that the consumer can only buy what is produced. My favorite example is that nobody can buy a house that hasn't been built. But other examples abound. Hot dog buns are sold in units of 8, while hot dogs are sold in units of 12. Printer companies sell a different printer every year, and jack up the prices of printer cartridges in prior models. Smart phones are almost required, you can't park a car in my town without using an app to register a parking payment. Manufactured obsolescence means that goods that could be cared for and maintained for ten years historically, must now be replaced every five; and repairs cost more now because instead of resoldering a wire on an electrical device, whole modules must be replaced and the old ones tossed out into ever growing landfills. Grocery stores no longer use dumpsters, but rather use trash compactors to prevent perfectly decent food from being scavenged away. Healthy food is filled with additives to increase profits, and sometimes to encourage addiction, resulting in an ever diminishing quality of food, making all of us sicker. Monthly subscriptions for various services has become almost ubiquitous. Our entire society practically forces paid consumption - forces it. We are not a consumer society, we are a PRODUCER SOCIETY. Government statistics measures GNP, Nothing must prevent the ever increasing production of goods. And heaven forbid if prices or consumer confidence drops.

It is always characteristic of the "haves" to blame the "have nots", the disenfranchised, for their issues. Corporations, in their unmediated quest for profit, takes advantage of the consumer. First, they do everything they can to minimize costs, polluting their environments, that then need to be cleaned up by the very same consumers that bought their products. No longer are goods priced at cost plus 30%; rather, market research pin-points the precise pain point that limits the price most customers will spend for goods and services, and uses that for guidance, pocketing the excess as "profit". And don't even get me started as to how most of these consumers earn their living. They are disrespected by both their bosses, and by their customers.

"Consumers" are disrespected by producers, manipulated by them through advertising, exploited, tricked, coerced, and blamed for the rise and fall of economies. They are seen as nothing more than pawns and marks. Do not tell me that the individual consumer has any control over any of this.

Contrary to the assertion that the modern American consumer experience is that of freedom, it is an experience of bondage to a vast array of powers greater than ones own. Governments - federal, state, and local, Corporations, policies, laws, rules, regulations, even HOAs. All designed to make the individual feel small, unimportant and powerless. It is no wonder that societal rage is on the rise.

In the first Century there was a movement in Palistine that preached a message of freedom in a world of exploitation by the principalities and powers of the age. The cost of following this message to those who followed "The Way" was extremely steep, persecution and death in many cases. Yet this movement grew, in spite of the negative market forces weighed against it. People heard this message, heard the testimony about the one who had stood up to the bullies of heavenly and earthly power, and came out of the ordeal glorified.

That is the God that motivates.

We need fewer apologetics defending a God in the mold of Capitalist exploitation, a corporate middle manager, or worse - a CEO. He is not a God that offers any kind of redemption. We need more evangelists looking outside of our self imposed silo Churches preaching of a God better then the fallen world around us. Better than that world, and able to transform it.

It's NOT the consumer, it's almost never the consumer, it's the product. No amount of advertising in the world will redeem a subpar product.

A man can't buy a house that's not being sold, and he's not obligated to buy the one that is.

Glory to God, the maker of heaven and earth and all things therein. Have Mercy upon me, A Sinner.

[togethermediation]

Navigating Harmony: The Role of Family Mediation Services in the UK

In the intricate tapestry of family life, conflicts and disputes can sometimes unravel the strongest bonds. In the United Kingdom, Family Mediation Services play a pivotal role in helping families weave those bonds back together, providing a structured and supportive environment for resolving conflicts amicably. These services are instrumental in fostering communication, understanding, and ultimately, maintaining the fabric of family relationships.

Family Mediation Services act as a neutral third party, facilitating open and constructive dialogue among family members facing disputes, whether it be related to divorce, child custody, inheritance, or other familial issues. This alternative dispute resolution method has gained prominence in recent years due to its effectiveness in fostering collaboration and reducing the emotional and financial toll associated with lengthy court battles.

One of the key benefits of family mediation is its voluntary nature. Families can opt for mediation willingly, allowing them to have greater control over the resolution process. In contrast to court proceedings, mediation empowers individuals to voice their concerns, needs, and preferences in a less adversarial setting. Trained mediators guide the conversation, ensuring that all parties have an equal opportunity to express themselves.

Moreover, Family Mediation Services UK focuses on the best interests of children when parents are navigating the challenges of separation or divorce. Mediators work to create a child-focused environment, considering the emotional and practical needs of the children involved. This approach helps parents develop mutually agreeable parenting plans, fostering a stable and supportive environment for the children amidst family transitions.

In addition to its voluntary nature and child-focused approach, family mediation is known for its efficiency. Court processes can be lengthy and costly, whereas mediation offers a more time-efficient and cost-effective solution. Families can often resolve their issues in a few sessions, saving both time and resources while mitigating the emotional toll that extended legal battles can bring.

The United Kingdom recognizes the importance of Family Mediation Services and actively encourages their use. Legal professionals, including solicitors and judges, often recommend mediation as a first step in resolving family disputes. The government has also taken steps to promote awareness about mediation services, highlighting their benefits and accessibility.

It's essential to note that while family mediation can address a wide range of issues, it may not be suitable for every situation. Cases involving domestic violence or situations where there is a significant power imbalance may not be appropriate for mediation. In such cases, the safety and well-being of the individuals involved take precedence, and alternative legal avenues may be explored.

In conclusion, Online Family Mediation Services in the UK serve as a vital bridge to resolution in times of familial discord. By fostering open communication, focusing on the best interests of children, and providing a voluntary and efficient alternative to court proceedings, mediation plays a crucial role in preserving the fabric of family relationships. In a society that values harmony and collaboration, these services continue to be a beacon of hope for families navigating the complexities of conflict and seeking a path toward reconciliation.

Source & Reference: https://sites.google.com/view/together-mediation-services/navigating-harmony-the-role-of-family-mediation-services-in-the-uk

[themarketinsights]

Minichromosomal Technology Market to Develop New Growth Story

Latest released the research study on Global Minichromosomal Technology Market, offers a detailed overview of the factors influencing the global business scope. Minichromosomal Technology Market research report shows the latest market insights, current situation analysis with upcoming trends and breakdown of the products and services. The report provides key statistics on the market status, size, share, growth factors of the Minichromosomal Technology The study covers emerging player’s data, including: competitive landscape, sales, revenue and global market share of top manufacturers are Thermo Fisher Scientific (United States), Merck KGaA (Germany), Horizon Discovery Limited (United Kingdom), Lonza (Switzerland), GenScript (United States), Eurofins Scientific (Luxembourg), Sangamo Therapeutics (United States), Editas Medicine (United States), CRISPR Therapeutics (Switzerland), Precision Biosciences (United States)

Free Sample Report + All Related Graphs & Charts @: https://www.advancemarketanalytics.com/sample-report/177066-global-minichromosomal-technology-market

Minichromosomal Technology Market Definition:

Genetic engineering is a scientific tool that is utilised in a wide range of fields, including plant, animal, and human sciences. Plant genetic engineering has revolutionised plant science, with the first generation of transgenic crops being the most widely accepted technique in contemporary agriculture. However, genetic engineering has certain limits, and new methods are still needed to address difficulties such as gene stacking, transgene location effects, and insertion-site complexity. Because of the plasticity of the genome in plants compared to other taxa and the ability to manipulate and analyse such chromosomes throughout the life cycle and at various stages of development, engineered minichromosomes, also known as artificial chromosomes or synthetic chromosomes, are likely to have numerous applications in both basic and applied research. A minichromosome is a very tiny form of a chromosome either through de novo synthesis utilising cloned chromosome components or by telomere-mediated truncation of endogenous chromosomes.

Market Trend:

Increasing Applications in Biopharmaceutical Segment

Market Drivers:

Rising Government Expenditure Genomics Projects

Growth in Biotechnology Industry

 

Market Opportunities:

Increasing Biotech Infrastructure Cross Asian Regions

The Global Minichromosomal Technology Market segments and Market Data Break Down are illuminated below:

by Type (Reagents & Consumables, Software & Systems, Services), Application (Cell Line Engineering, Genetic Engineering, Diagnostic Applications, Drug Discovery & Development, Others), End Use (Pharmaceutical Companies, Biotechnology Companies, Academic & Government Research Institutes)

Region Included are: North America, Europe, Asia Pacific, Oceania, South America, Middle East & Africa

Country Level Break-Up: United States, Canada, Mexico, Brazil, Argentina, Colombia, Chile, South Africa, Nigeria, Tunisia, Morocco, Germany, United Kingdom (UK), the Netherlands, Spain, Italy, Belgium, Austria, Turkey, Russia, France, Poland, Israel, United Arab Emirates, Qatar, Saudi Arabia, China, Japan, Taiwan, South Korea, Singapore, India, Australia and New Zealand etc.

Enquire for customization in Report @: https://www.advancemarketanalytics.com/enquiry-before-buy/177066-global-minichromosomal-technology-market

Strategic Points Covered in Table of Content of Global Minichromosomal Technology Market:

Chapter 1: Introduction, market driving force product Objective of Study and Research Scope the Minichromosomal Technology market

Chapter 2: Exclusive Summary – the basic information of the Minichromosomal Technology Market.

Chapter 3: Displayingthe Market Dynamics- Drivers, Trends and Challenges of the Minichromosomal Technology

Chapter 4: Presenting the Minichromosomal Technology Market Factor Analysis Porters Five Forces, Supply/Value Chain, PESTEL analysis, Market Entropy, Patent/Trademark Analysis.

Chapter 5: Displaying market size by Type, End User and Region 2015-2020

Chapter 6: Evaluating the leading manufacturers of the Minichromosomal Technology market which consists of its Competitive Landscape, Peer Group Analysis, BCG Matrix & Company Profile

Chapter 7: To evaluate the market by segments, by countries and by manufacturers with revenue share and sales by key countries (2021-2026).

Chapter 8 & 9: Displaying the Appendix, Methodology and Data Source

Finally, Minichromosomal Technology Market is a valuable source of guidance for individuals and companies in decision framework.

Data Sources & Methodology The primary sources involves the industry experts from the Global Minichromosomal Technology Market including the management organizations, processing organizations, analytics service providers of the industry’s value chain. All primary sources were interviewed to gather and authenticate qualitative & quantitative information and determine the future prospects.

In the extensive primary research process undertaken for this study, the primary sources – Postal Surveys, telephone, Online & Face-to-Face Survey were considered to obtain and verify both qualitative and quantitative aspects of this research study. When it comes to secondary sources Company's Annual reports, press Releases, Websites, Investor Presentation, Conference Call transcripts, Webinar, Journals, Regulators, National Customs and Industry Associations were given primary weight-age.

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What benefits does AMA research study is going to provide?

Latest industry influencing trends and development scenario

Open up New Markets

To Seize powerful market opportunities

Key decision in planning and to further expand market share

Identify Key Business Segments, Market proposition & Gap Analysis

Assisting in allocating marketing investments

Definitively, this report will give you an unmistakable perspective on every single reality of the market without a need to allude to some other research report or an information source. Our report will give all of you the realities about the past, present, and eventual fate of the concerned Market.

Thanks for reading this article; you can also get individual chapter wise section or region wise report version like North America, Europe or Southeast Asia.

Contact Us:

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[bespokemediationservice]

Bespoke Mediation Service

Divorce or relationship disputes can be extremely difficult and the parties involved can often really benefit from specialist support.

Bespoke Mediation Service can help you find a way through the conflict and move towards a brighter future.

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[alishaclarkeblogs]

GRE Coaching Classes in Rajkot - Best GRE Training Center in Rajkot

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Let’s Join in Saarthi's GRE Coaching Classes in Rajkot and Study With India's Most Qualified Professor.

The Saarthi Foundation, Best Classes for GRE in Rajkot, specialises in delivering an excellent education while thoroughly prepare students for examinations. GRE is a brief name for Graduate Record Exam. It is mandatory for entrance into higher education and professional business schools in the United States.

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Although there are success memories of people who passed the GRE without tutoring, enrolling in an academic programme enhances the probability of success. So, choose the top GRE Classes in Rajkot that is suited for you according to the instructors experience, cost of tuition, the distance from your house, and your specific GRE weaknesses and strengths.

Do you know? SEF always believe in Indian students that get excellent educations at highly ranked colleges while applying their understanding, abilities, and expertise to the regions in which they are living and working in their careers. We aim for straightforward and truthful communication. For self-evaluation and better comprehension, consistently practise examinations are scheduled which include problem solving sessions.

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Saarthi Education Foundation will offer you Step by step guidance to reach your Dream University and college in the US. GRE is administered practically every day of the year; however, booking a GRE exam at a proper time and with the appropriate level of the preparation needs the guidance of an instructor. SEF is a leading institution for dedicated class and online examination preparation for overseas educational admissions exams such as the, GRE, TOEFL, PTE and IELTS.

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[brookstonalmanac]

Events 5.13

1373 – Julian of Norwich has visions of Jesus while suffering from a life-threatening illness, visions which are later described and interpreted in her book Revelations of Divine Love. 1501 – Amerigo Vespucci, this time under Portuguese flag, set sail for western lands. 1568 – Mary Queen of Scots is defeated at the Battle of Langside, part of the civil war between Queen Mary and the supporters of her son, James VI. 1612 – Sword duel between Miyamoto Musashi and Sasaki Kojiro on the shores of Ganryū Island. Kojiro dies at the end. 1619 – Dutch statesman Johan van Oldenbarnevelt is executed in The Hague after being convicted of treason. 1654 – A Venetian fleet under Admiral Cort Adeler breaks through a line of galleys and defeats the Turkish navy. 1779 – War of the Bavarian Succession: Russian and French mediators at the Congress of Teschen negotiate an end to the war. In the agreement Austria receives the part of its territory that was taken from it (the Innviertel). 1780 – The Cumberland Compact is signed by leaders of the settlers in the Cumberland River area of what would become the U.S. state of Tennessee, providing for democratic government and a formal system of justice. 1804 – Forces sent by Yusuf Karamanli of Tripoli to retake Derna from the Americans attack the city. 1830 – Ecuador gains its independence from Gran Colombia. 1846 – Mexican–American War: The United States declares war on the Federal Republic of Mexico following a dispute over the American annexation of the Republic of Texas and a Mexican military incursion. 1861 – American Civil War: Queen Victoria of the United Kingdom issues a "proclamation of neutrality" which recognizes the Confederacy as having belligerent rights. 1861 – The Great Comet of 1861 is discovered by John Tebbutt of Windsor, New South Wales, Australia. 1861 – Pakistan's (then a part of British India) first railway line opens, from Karachi to Kotri. 1862 – The USS Planter, a steamer and gunship, steals through Confederate lines and is passed to the Union, by a southern slave, Robert Smalls, who later was officially appointed as captain, becoming the first black man to command a United States ship. 1888 – With the passage of the Lei Áurea ("Golden Law"), the Empire of Brazil abolishes slavery. 1912 – The Royal Flying Corps, the forerunner of the Royal Air Force, is established in the United Kingdom. 1917 – Three children report the first apparition of Our Lady of Fátima in Fátima, Portugal. 1940 – World War II: Germany's conquest of France begins, as the German army crosses the Meuse. Winston Churchill makes his "blood, toil, tears, and sweat" speech to the House of Commons. 1941 – World War II: Yugoslav royal colonel Dragoljub Mihailović starts fighting against German occupation troops, beginning the Serbian resistance. 1943 – World War II: Operations Vulcan and Strike force the surrender of the last Axis troops in Tunisia. 1945 – World War II: Yevgeny Khaldei's photograph Raising a Flag over the Reichstag is published in Ogonyok magazine. 1948 – Arab–Israeli War: The Kfar Etzion massacre occurs, a day prior to the Israeli Declaration of Independence. 1950 – The inaugural Formula One World Championship race takes place at Silverstone Circuit. The race was won by Giuseppe Farina, who would go on to become the inaugural champion that year. 1951 – The 400th anniversary of the founding of the National University of San Marcos is commemorated by the opening of the first large-capacity stadium in Peru. 1952 – The Rajya Sabha, the upper house of the Parliament of India, holds its first sitting. 1954 – The anti-National Service Riots, by Chinese middle school students in Singapore, take place. 1958 – During a visit to Caracas, Venezuela, the US Vice President Richard Nixon's car is attacked by anti-American demonstrators. 1958 – May 1958 crisis: A group of French military officers lead a coup in Algiers demanding that a government of national unity be formed with Charles de Gaulle at its head in order to defend French control of Algeria. 1958 – Ben Carlin becomes the first (and only) person to circumnavigate the world by amphibious vehicle, having travelled over 17,000 kilometres (11,000 mi) by sea and 62,000 kilometres (39,000 mi) by land during a ten-year journey. 1960 – Hundreds of University of California, Berkeley students congregate for the first day of protest against a visit by the House Committee on Un-American Activities. 1967 – Dr. Zakir Husain becomes the third President of India. He is the first Muslim President of the Indian Union. He holds this position until August 24, 1969. 1969 – May 13 Incident involving sectarian violence in Kuala Lumpur, Malaysia. 1971 – Over 900 unarmed Bengali Hindus are murdered in the Demra massacre. 1972 – A fire occurs in the Sennichi Department Store in Osaka, Japan. Blocked exits and non-functional elevators result in 118 fatalities (many victims leaping to their deaths). 1972 – The Troubles: A car bombing outside a crowded pub in Belfast sparks a two-day gun battle involving the Provisional IRA, Ulster Volunteer Force and British Army. Seven people are killed and over 66 injured. 1980 – An F3 tornado hits Kalamazoo County, Michigan. President Jimmy Carter declares it a federal disaster area. 1981 – Mehmet Ali Ağca attempts to assassinate Pope John Paul II in St. Peter's Square in Rome. The Pope is rushed to the Agostino Gemelli University Polyclinic to undergo emergency surgery and survives. 1985 – Police bombed MOVE headquarters in Philadelphia, killing six adults and five children, and destroying the homes of 250 city residents. 1989 – Large groups of students occupy Tiananmen Square and begin a hunger strike. 1990 – The Dinamo–Red Star riot took place at Maksimir Stadium in Zagreb, Croatia between the Bad Blue Boys (fans of Dinamo Zagreb) and the Delije (fans of Red Star Belgrade). 1992 – Li Hongzhi gives the first public lecture on Falun Gong in Changchun, People's Republic of China. 1995 – Alison Hargreaves, a 33-year-old British mother, becomes the first woman to conquer Everest without oxygen or the help of sherpas. 1996 – Severe thunderstorms and a tornado in Bangladesh kill 600 people. 1998 – Race riots break out in Jakarta, Indonesia, where shops owned by Indonesians of Chinese descent are looted and women raped. 1998 – India carries out two nuclear weapon tests at Pokhran, following the three conducted on May 11. The United States and Japan impose economic sanctions on India. 2005 – Andijan uprising, Uzbekistan; Troops open fire on crowds of protestors after a prison break; at least 187 people were killed according to official estimates. 2006 – São Paulo violence: Rebellions occur in several prisons in Brazil. 2011 – Two bombs explode in the Charsadda District of Pakistan killing 98 people and wounding 140 others. 2012 – Forty-nine dismembered bodies are discovered by Mexican authorities on Mexican Federal Highway 40. 2013 – American physician Kermit Gosnell is found guilty in Pennsylvania of murdering three infants born alive during attempted abortions, involuntary manslaughter of a woman during an abortion procedure, and other charges. 2014 – An explosion at an underground coal mine in southwest Turkey kills 301 miners.

[kayla1993-world]

Canadian Diplomats to be Evacuated from violence-stricken Sudan

Canadian diplomats in Sudan will be evacuated amid intensifying violence between the Sudan Armed Forces (SAF) and the paramilitary Rapid Support statement released by Global Affairs Canada on Sunday. “The situation in Sudan has rapidly deteriorated impossible to safeguard the safety and security of our staff in Khartoum,” the statement reads. “After consulting with Canada’s ambassador to Sudan, the decision has been made to temporarily suspend our operations in Sudan.” The statement also explained that Canadian diplomats will work outside with the Sudanese government, neighboring countries, and the international community. All parties will work on a coordinated response to help Canadians still inside Sudan’s borders. This decision follows a more extensive trend of international diplomats being evacuated from the war-stricken region. Two weeks ago, Sudan erupted over a planned transition to democratic rule, intensifying deep-rooted conflict between the RSF and SAF. The fighting between these two factions resulted from the two commanders’ unwillingness to relinquish their power despite promises of new elections by the end of 2023. They killed more than 400 people since April 15. Last Thursday, Canada’s Foreign Affairs Minister Mélanie Joly said there were no means of evacuating Canadians from Sudan as Khartoum was inaccessible. According to Global Affairs Canada, there are 1,596 Canadians known to be in Sudan. However, since registration is voluntary, the exact number remains unknown. “We urge all parties to agree to an immediate ceasefire and to engage in mediation efforts supported by regional partners that promote dialogue and a lasting peace,” Global Affairs Canada’s statement said. “Canada remains committed to supporting the people of Sudan in their desire to secure a democratic future and a peaceful transition to a civilian-led government.” On Saturday, United States President Joe Biden announced that the U.S. military had carried out of embassy personnel in Sudan, calling the rising violence “unconscionable” and thanking American troops for safe extraction. Diplomats were airlifted and transported to an undisclosed location by officials. On Twitter, United Kingdom Prime Minister Rishi Sunak announced that U.K. armed forces have evacuated British diplomats and their families. “I pay tribute to the commitment of our diplomats and bravery of the military personnel who carried out this difficult operation,” Sunak tweeted Sunday. As international diplomats continue to assess the changing situation in Sudan, Global Affairs Canada recognizes the need to offer service and security for Canadians affected by the violence. “The Canadian embassy will resume operations in Khartoum as soon as the situation in Sudan allows us to guarantee proper service and the safety and security for our staff,” the statement says.

[swldx]

BBC 0513 16 Jan 2024

7285Khz 0458 16 JAN 2024 - BBC (UNITED KINGDOM) in ENGLISH from ASCENSION ISLAND. SINPO = 35233. English, s/on @0458z with Bowbells int. fb ID, pips and Newsday preview. @0501z World News anchored by Chris Berrow. § Israel and Hamas have agreed a Gaza ceasefire and hostage release deal following 15 months of war, mediators Qatar and the US say. Qatari Prime Minister Sheikh Mohammed bin Abdul Rahman Al Thani said the agreement would come into effect on Sunday so long as it was approved by the Israeli cabinet. US President Joe Biden said it would "halt the fighting in Gaza, surge much needed-humanitarian assistance to Palestinian civilians, and reunite the hostages with their families". Israeli Prime Minister Benjamin Netanyahu said the deal's final details were still being worked on, but he thanked Biden for "promoting" it. Hamas leader Khalil al-Hayya said it was the result of Palestinian "resilience". § Outgoing US President Joe Biden warned of a "dangerous" oligarchy taking shape in America, as he delivered his farewell address and brought a decades-long career in politics to an end. "Today, an oligarchy is taking shape in America of extreme wealth, power and influence that really threatens our entire democracy, our basic rights and freedom," he said on Wednesday. Biden, 82, took aim at an ultra-wealthy "tech-industrial complex" which he said could wield unchecked power over Americans. He also used his final televised speech from the White House to issue warnings about climate change and social media disinformation. § Canada’s outgoing Prime Minister Justin Trudeau said on Wednesday that “nothing is off the table” when it comes to responding to proposed tariffs by President-elect Donald Trump, but that no single region of the country should bear the full brunt of that response. Trump has threatened to impose 25% tariffs on all Canadian imports. § Cuba on Wednesday began releasing prisoners jailed following anti-government protests in 2021, making good on a deal agreed with the Biden administration this week. Outgoing U.S. President Joe Biden on Tuesday removed Cuba from a blacklist of nations that sponsor terrorism and rolled back a raft of sanctions implemented by Donald Trump during his first presidency that have contributed to the communist-run island's worst economic crisis in decades. § Red Flag warnings advising of extreme wildfire danger expired across the Los Angeles area late on Wednesday, but forecasters warned that dry and windy conditions will persist on Thursday, and that the threat of blazes remained. The National Weather Service added that the respite for fire-ravaged Los Angeles will be short, with high chances for renewed Red Flag warnings - when ideal fire conditions of high winds and low humidity dominate - starting again on Sunday. § South Korea's arrested President Yoon Suk Yeol does not intend to take part in a second day of questioning on Thursday, his lawyer said, further stonewalling a criminal probe into whether he committed insurrection with his martial law bid. Yoon, the first sitting South Korean president to be arrested, was taken to the Seoul Detention Centre on Wednesday evening after refusing to cooperate, where he was expected to have spent the night in a solitary cell. § Popular Bollywood actor Saif Ali Khan has been hospitalised for multiple stab injuries after an intruder reportedly barged into his house and attacked him. The attack took place early Thursday morning at an upscale neighbourhood of Mumbai city, where Khan lives with his family. @0506z “Newsday” begins. Backyard gutter antenna w/MFJ-1020C active antenna (used as a preamplifier/preselector), JRC NRD-535D, 250kW, beamAz 115°, bearing 103°. Received at Plymouth, MN, United States, 9763KM from transmitter at Ascension Island. Local time: 2258.