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In the world of medical innovation, Dr. Vivek Vij is a famous surgeon.
Renowned for elevating liver transplant survival rate, Dr. Vivek Vij is a famous surgeon at the forefront of medical innovation. With expertise that spans decades, he has transformed the landscape of liver transplant surgery in India. Dr. Vij's commitment to affordable healthcare ensures that liver transplant surgery costs in India remain accessible, providing hope to countless patients in need. Trust in his expertise for life-changing liver transplants.
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Amanita phalloides, the deadliest mushroom of the world
Commonly known as "death cap" internationally, this mushroom of European origin occurs now in all countries with temperate climate zones worldwide. It is particularly abundant in northern, central and eastern Europe, including Germany, where it forms an ectomycorrhiza symbiosis with broad leaf tree species.
Its similarity to edible mushroom species such as the straw mushroom and the white Caesar make it particularly dangerous. It may also be confused with the cultivated mushroom and the field or meadow mushroom, although clear distinguishing features exist.
Its deadly poison are heat-stable polycyclic oligopeptides of the amatoxin group with a lethal dose of about 0.1 mg per kg of body weight. This is equivalent to 20 to 40 grams of mushroom for an adult and 1 to 2 grams for children. The poison survives cooking, freezing and drying.
Amatoxins are highly efficient inhibitors of the RNA polymerase and disrupt gene expression in human cells. This causes nausea, vomiting and severe diarrhea about 8 to 12 hours after ingestion. At this time, the toxin has already distributed throughout the whole body and enriched in the liver, so any attempt to bind the toxin in the digestive tract is inefficient. The disruption of gene expression in the liver causes the liver cells to die and the liver to dissolve. Blood coagulation is severely disturbed, leading to severe interior bleeding. Hepathic encephalopathy leading to coma is the final cause of death and occurs six to ten days after ingestion.
Early stages or a mild poisoning is treated with Silymarin, an extract from the milk thistle, which inhibits the uptake of amatoxins into the liver cells. The ultimate cure for severe cases of amatoxin poisoning is a liver transplant. Due to these therapies, the death rate of cases of Amanita poisoning has been reduced from almost 100 % to 10 to 15 %. Early diagnosis and quick action are the prerequisites for a poisitive outcome.
Mushroom hunters in Europe usually know to distinguish the death cap from edible fungi, so cases among Europeans are rare. Immigrants, however, have more frequently suffered from Amanita poisonings. Many of the victims of the last decade came from Syria, where the death cap is unknown in many regions. In the USA, immigrants from south east Asia are frequent victims of Amanita poisoning. In Australia, signs warn mushroom hunters to abstain from their leisure activity in areas where Amanita phalloides has been introduced.
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The death cap mushroom (Amanita phalloides) is one of the most toxic and deadly mushrooms in the world. It’s responsible for the majority of fatal mushroom poisonings, as it contains potent toxins called amatoxins that are highly resistant to heat and enzymes, meaning they remain toxic even after cooking.
Characteristics of the Death Cap
Appearance:
Cap: It has a pale green to olive-brown, smooth cap that can be mistaken for other edible mushrooms. The cap is usually 5–15 cm in diameter, with a somewhat sticky surface when wet.
Gills: The gills beneath the cap are white and free (not attached to the stalk).
Stalk: The stalk is white or pale, with a swollen base that may have a cup-like structure (volva).
Spore Print: The spore print of the death cap is white.
Habitat:
It is most commonly found in temperate regions, particularly in Europe and North America, often growing in association with hardwood trees like oak, chestnut, and pine.
It thrives in moist environments, typically appearing in late summer or fall.
Toxicity and Symptoms of Poisoning
Death cap mushrooms contain several toxic compounds, with amatoxins being the most lethal. These toxins inhibit RNA polymerase II, a critical enzyme in protein synthesis, leading to cell death—especially in the liver and kidneys.
Poisoning Stages:
Latency Period (6-12 hours): After ingestion, there is a deceptive phase with no symptoms, which can lull people into a false sense of security.
Gastrointestinal Phase (12-24 hours): Violent abdominal pain, vomiting, and diarrhea occur, leading to dehydration and electrolyte imbalance.
Apparent Recovery (1-2 days): Symptoms seem to improve, but this is an illusion. Meanwhile, liver and kidney damage is worsening internally.
Liver/Kidney Failure (3-5 days): If untreated, the liver and kidneys begin to fail, leading to coma and potentially death.
Treatment
Immediate medical attention is critical. Hospital treatment often involves:
Activated Charcoal: Administered to absorb any remaining toxins.
Intravenous fluids: To manage dehydration.
Liver Transplant: In severe cases, patients may require a liver transplant to survive.
Unfortunately, even with aggressive treatment, the death rate for death cap mushroom poisoning can range from 10–30%.
Edibility Confusion
One of the most dangerous aspects of the death cap is its resemblance to edible mushrooms. It can easily be confused with mushrooms like the paddy straw mushroom (Volvariella volvacea) and the caesar’s mushroom (Amanita caesarea), particularly in its early stages of growth.
Cultural Impact and History
Death caps have a long and infamous history:
In ancient Rome, they were believed to have been used in political assassinations, notably in the death of Emperor Claudius.
Poisonings continue to occur worldwide, often involving foragers who mistake the death cap for an edible mushroom, particularly in areas where foraging is common.
Conclusion
The death cap mushroom is a highly toxic species that requires caution and awareness. It highlights the importance of proper identification and knowledge for those who forage mushrooms.
Get yourself my art works to add to your collection of mushrooms:
#ainight#handmade#art#mushroomcore#artists on tumblr#mushroom art#artists of tumblr#mushrooms#stay vigilant#tumblr#artists of threadless#threadless#death cap#poisonous mushrooms#poison#dead#deadly#mushroom love#mushrooms that can kill you
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Got a three-fer here for @mungrovebingos!
Summary: Billy's recovery has been a long process, and his spirits are low, even five years after his near death at Starcourt Mall. Eddie has just the thing to boost Billy's morale- and even Mother Nature decides to lend a hand. Rating: Mature Tags/Warnings: PTSD, Body Image Issues, Post injury recovery, scars, hospital stays, medical content, serious injuries, hurt/comfort. Read here, or on AO3!
Once, Billy had thought that living was hard. That dying would have been easier.
The truth was, neither was easier.
Living was hard, because it meant dealing with Neil, protecting and caring for a step-sister he’d never asked for, while trying to graduate, get a job, and get the fuck out of the hellhole that was supposed to be home- and try not to be eaten alive by the guilt of leaving Max to Neil’s cruelty.
Nearly dying had been excruciating. The pain didn’t end, and death didn’t come for him; it had simply sat there on the sidelines and laughed at him, taunting him with release as he succumbed to a coma instead.
Billy had woken up to a world of pain like he’d never experienced.
His entire digestive system was rocked to its core from the chemicals he’d been forced to consume- as well as whatever that thing had pumped into him. His liver was on its last legs, and doctors had placed him on a transplant list in the likely chance it failed.
It was still nothing compared to the damage to his torso.
He had sustained a gaping wound in his chest, his sternum broken in two. Ribs on each side were broken, his spleen had ruptured- and removed while he was in his coma- and he’d lost a kidney.
He’d been placed in a medical coma for his own sanity- with only ten percent of his liver functioning, they couldn’t give him any pain medication stronger than Tylenol. To spare him the agony, they’d put him under, hooking him up to a ventilator, with a feeding tube that went directly into his small intestine, since his stomach was so damaged. He was also put on a high dose of daily antacids to help his stomach heal.
Meanwhile, his chest had been operated on multiple times, his sternum put back together with a titanium fixation plate, his ribs left to heal naturally, and the organs damaged beyond repair were removed- his spleen, the kidney, a large part of his liver, gall bladder, and what remained of his thymus.
The doctors had told Neil not to get his hopes up, that his chances of survival were less than twenty percent.
Neil didn’t come back after that last consult- in fact, he’d left Hawkins altogether.
To everyone’s surprise, Billy proved them wrong.
He lived. He healed.
He started to come back, his body pulling itself together. The ulcers in his stomach and the inflammation in his intestines healed. His bones slowly knit themselves together. His surviving kidney was tolerating the doubled load better than expected, and his liver was regenerating faster than anyone had dared to dream- going from ten percent functionality to nearly fifty.
Billy Hargrove would survive- like he always did. And like everything else in his life that had to be survived, his recovery would be long, painful, and slow.
All the while, in his coma, Billy dreamed of the Pacific Ocean. He dreamed of memories of cold water, seven foot waves, sandals covered in sand, and an orca calf with freckles on the white parts of its jaw and lower belly, leaping out of the water in a moment of pure, joyous freedom.
It was the snoring he’d woken up to. He’d opened his eyes, looked to his right, and found Eddie there in the chair, arms folded on Billy’s bed, head resting on them as he snored. His messy hair was a nightmare, and Billy could tell from a glance that Eddie hadn’t changed in days- he probably only left to change or shower when hospital staff told him to.
Billy had let out a soft snort through his nose- muffled by the cannula feeding oxygen into his nose- then put his hand on Eddie’s head, stroking the disaster that was his hair. Eddie had stirred, lifting his head, and his big brown eyes became even bigger, filling with tears, glittering in the fluorescent lights.
“Welcome back,” he’d said, tears spilling over cheeks that had the imprint of the sleeves of his jacket.
“What’d I miss?” Billy had asked, voice dry, hoarse and rough from months of being on a ventilator.
He was worried the feelings that had started to cultivate between them had faded, that Eddie might change his mind after seeing the damage done to him, but Eddie had let out a sobbing laugh, and without a word, simply leaned over and kissed him- answering any silent doubts Billy woke up with.
That was nearly five years ago, and after grueling physical therapy, after trauma therapy that was even harder, Billy was as close to being “back to normal” as he ever could be.
His chest was tight, stiff, the large scar was unpleasant to look at- shiny, gnarled tissue that was waxy, hard, and disconnected from his chest wall. It restricted his movements, made it hard to get comfortable when sleeping, and it constantly was shot through with jolts of electricity, or bouts of itching deep under the scar tissue.
The doctors assured him the pain and the itching was normal, that it was good- it meant he was healing. To Billy, it was just a reminder of the traumatic injury that caused it, and he hated it. He’d rather it stay numb than have it heal.
He was tired of the pain shooting through his sternum and ribs, waking him from sleep, turning his dreams into nightmarish flashbacks of melted people piercing his chest and attempting to kill him as fanged tentacles sank their teeth into his sides, trying to rend him from limb to limb.
Billy was tired of waking up, drenched in a cold, acrid sweat that reeked of battery acid. The doctors told him it was from the high protein diet he’d been on to speed up his healing, but Billy still smelled the chemicals that the monster had made him choke down, still felt the burn of chlorine and boric acid in his throat.
He still couldn’t taste things properly, but his diet was so simple now, thanks to the damage done to his stomach, that it didn’t really matter much anyway.
He could only take Tylenol- anything else was too hard on his stomach and liver, and both were still recovering from what the monster had made him swallow. Billy didn’t bother with Tylenol- it didn’t touch his pain.
Weed helped, though. He and Eddie didn’t know if it would hurt his liver or not- and they sure as fuck weren’t going to ask doctors about it- but it helped. The high helped him sleep, calmed his anxiety responses to loud noises and bright lights. It didn’t entirely help his pain, but it soothed the inflammation of his scar tissue after his daily massaging.
Eddie had been consulting with some folks in Portland, and they’d sent him lotions and balms infused with cannabis oil. Beeswax, goat’s milk, castor oil with rosemary, lavender, or peppermint, cocoa butter- all different sorts of things for Billy to try.
They all helped a great deal with massaging his scars, and Eddie had been more than happy to rub his back down, tracing shapes in the patterns, kissing them when he was done, and telling Billy how much of a bad ass he looked.
Billy always scoffed, but the truth was, it helped him feel better about the scars. He used to go out shirtless, or with an open shirt or jacket, showing off the body he’d cultivated- muscular and tan, the 1980’s ideal.
Now, it was 1990, almost at the five year anniversary of his brush with death, and Billy wasn’t too fond of his body anymore. His range of movement, strength and flexibility were still restricted, and he had to keep his skin protected and covered to prevent the scars from becoming worse- they were already painful, since the larger ones were contracture scars.
Billy was thinner, struggling to keep up the muscle tone he’d once had, working so hard with physical therapy, massage and manipulation of his scar tissue to soften it up, and he was paler of skin and darker of hair while avoiding the sun to keep it from thickening his scars.
He’d been miserable, despite his progress, and it tore Eddie up to see him that way, so he’d suggested the road trip to California, to the coast Billy knew so well, had spoken so fondly of, and so often.
So they’d made the trip. It had been slow going- Billy didn’t have the stamina he used to for driving, so Eddie had taken the wheel, and dealt with Billy’s passenger-seat driving. They’d stopped at rest stops to save money, or shitty motels when the rest stops weren’t safe enough, and Eddie had patiently, lovingly worked out the knots in Billy’s muscles, massaged CBD balms into his scars, and they’d eaten pizza on lumpy or sagging mattresses, watching late night TV before sleeping.
There was a night where they stopped at a gas station in a questionable place where they attracted instant attention because they stood too close together at the line for the register. In the lot next to the gas station, the locals were having a riotous party that involved their jacked-up trucks that kept backfiring loudly.
Every bang, every hoot and holler that came from the trucks had Billy flinching, until he was actively shaking, a sweat breaking out on his face. Eddie hurried to pay when it was their turn, and the cashier gave Billy an odd look.
“You okay, hon?”
Billy clutched at the collar of his tank top, trying to cool himself down, and the top of his scar became visible. Eddie saw her expression change to horror.
“Shh,” Eddie hissed to her in a conspiratorial whisper as he handed her the money for the gas. “He was in the Army; combat damage, and he’s got that Post Traumatic stress thing.”
The woman nodded, her eyes going doleful.
“So young…. Thank you for your service, honey,” she said in a sorrowful tone, giving him a salute as Eddie gently herded him back to the car.
It had taken Billy nearly an hour to come down from the panic attack, and once he’d calmed, he fell asleep. Eddie elected to keep driving- Nebraska was no place for them to stop, and they were mere miles from the Colorado border.
It got easier, the further west they went. They weren’t going to San Diego- Billy knew those beaches, but the risk that Neil went back there was too high. The city was big, but so was Neil’s network of contacts that had found out Billy’s sexuality and spurred Neil’s decision to move to Hawkins.
The last thing Billy needed for his recovery was having Neil find him.
So instead, they were headed to Monterey Bay, south of San Francisco. Eddie had heard it was a good place for beginner surfers, which meant it would be easier for Billy to get back on the board, and indulge in some exercise that wouldn’t be too dangerous for him, while still being enjoyable.
He’d told Billy they were going to San Francisco to spend time in a place where there were fellow queer folks, and they could just disappear into the crowd for a bit, and be normal. The trip to Monterey Bay was a surprise.
And now, after a careful week of driving, they had reached Monterey Bay. It was three in the morning, and Billy was sleeping soundly in the front seat. Eddie did his best not to wake him as he stopped at a few motels, comparing prices, before finally settling on one that was cheap and right by the beach- it was the off season for another week or two, so prices and availability were at a premium.
Eddie booked their room for a week, then came back to the car. He opened Billy’s door and carefully, gently roused him from his sleep. Billy jerked awake with a snort, sitting up and looking around warily.
“Where are we?” he asked, voice thick with sleep. Eddie rubbed his shoulder and handed him the room key.
“The motel. Booked us in for a week. Let’s get you into a decent bed and get some actual sleep, yeah?”
Billy nodded, blinking sleep-fogged eyes as he got out of the car and did a full body stretch, only stopping when his scars tugged and protested. Eddie didn’t react to Billy’s sudden stiffening, the frustration in his face- the last thing Billy needed or wanted was pity. It meant his weakness was obvious, and Eddie didn’t want him to feel weak. Still, Eddie hauled their luggage out of the trunk of the car and carried it in, letting Billy unlock the door.
The room was nice and cool, and Billy sighed gratefully- he never did regain his heat tolerance, still preferring the cold to heat. Eddie didn’t mind- the colder it was, the easier it was to snuggle up to Billy while he slept, without overheating Billy in the process.
Billy went back outside to lock the car up as Eddie took inventory of the room. He was rather satisfied with it, all things considered- well worth the nightly cost of thirty bucks. It was a bit more than he wanted to spend, but the motel was clean, close to the beach, and since it wasn’t a hotel, it wasn’t as likely to fill up as quickly, giving them a bit of disconnect from the public.
The room had a sofa with a pull-out bed- which Eddie dumped their luggage on- and a single king-sized bed. It had a small table with two chairs, a dresser with two sets of drawers, a TV with a VCR, cable, and a mini fridge that actually had a separate freezer. The bathroom had a decent enough sized tub with a sliding door of frosted glass for the shower.
Eddie unpacked their clothes while Billy took a leak, and shed his clothes, changing into a fresh pair of boxers. He shoved his dirty clothes in a plastic shopping bag as Billy came out to wash his hands.
“Don’t forget to brush your teeth,” Eddie told him, pressing a kiss to his cheek before slipping past for his turn in the bathroom. Billy rolled his eyes good-naturedly, but still helped himself to the trial sized tube of toothpaste and the travel toothbrush left on the counter, too tired to dig through their bags for his own.
While Eddie prepped for bed, Billy closed the curtains tight, locked the door, slid the chain home, turned the thermostat down as far as it would go, and the AC on as high as possible. When Eddie emerged, hair and teeth brushed, the room had dropped by five degrees, and Billy was sprawled on the bed. He’d peeled the blankets back, folding them so Eddie could have them all.
“Gonna get cold as hell in here,” Eddie commented, sliding under the covers and nestling up against Billy’s side.
Billy was resting on his back, arm outstretched so Eddie could curl against his side, using his chest as a pillow. His scars had finally healed to the point where Eddie could rest his cheek on Billy’s chest without causing him discomfort, and it was a major milestone in Billy’s recovery- the reclamation of his intimacy with Eddie.
“So what’s the plan tomorrow… or later, rather?” Billy said, voice already thick with sleep again, lulled by the siren song of freezing AC, Eddie’s warmth, and a comfortable bed.
On the night stand, the alarm clock glared at them with red digits, telling them it was four am. Eddie closed his eyes, ignoring it- time didn’t matter when they were on vacation- and nuzzled into Billy’s chest. His heartbeat was strong and steady under his cheek, reassuring and soothing.
“No plan,” Eddie murmured. “Nothing pressing, anyway. But there is a surprise.”
“A surprise?” Billy asked, and Eddie heard his heart speed up a bit. Eddie stroked his scars gently.
“Nothing bad, I promise,” he soothed. “Just… listen.”
As if trying to help him out, the AC stopped humming, having reached the set temperature. Bill was quiet, and Eddie waited as the sound of waves reached his ears.
“We’re right by the beach,” Billy said wonderingly. “How’d you afford a motel in San Francisco on the beach, babe?”
“I didn’t. We’re at Monterey Bay,” Eddie told him, smiling.
“Eddie….”
“You like the cold even more now, so I figured, it’s not full tourist season yet, so the beach won’t be as crowded, the water will be perfect for you, and the waves are decent, but not overwhelming, so you can surf a bit without overdoing it.”
Billy made a soft sound in his throat that sounded suspiciously like a sob being choked back. He rolled onto his side and wrapped his arms and legs around Eddie, clinging to him like a piece of flotsam in a flood.
“Thank you, Eddie,” he whispered into Eddie’s hair.
Eddie smiled in the darkness, hearing Billy’s heartbeat, the waves outside, and feeling Billy’s warmth seeping into the bed, into his bones, reigniting the fatigue that he’d been fighting all night.
“For now, let’s sleep,” he told Billy, stroking his back. “And when we’re rested, let’s go to the beach.”
Billy nodded, and with one final shudder, his muscles relaxed, and he stopped fighting the fatigue born of anxiety, a long car ride, and worry about the unknown, succumbing to sleep- and taking Eddie with him.
——
Their fatigue was deeper than either of them realized- neither of them woke until nearly five in the evening, sleeping more than twelve hours.
It was Billy who woke up first, roused by the sound of the waves and the gnawing of his stomach. He untangled himself from Eddie’s arms and legs, then slid out of bed and moved to the bag of snacks on the sofa. A half empty bag of beef jerky called his name, and he sat on the foot of the bed, gnawing on it, staring into space contentedly.
Eddie’s breathing was starting to quicken, and he stirred under the blankets. His stomach let out a roar of protest, and with a grumble, he sat up, rubbing at his eyes. Billy tried not to laugh at the mess his hair had become- as it always was when he woke up.
“Hungry?” he asked, holding out the bag. “There’s a quarter left, give or take.”
Eddie shook his head, yawning and stretching, his back popping.
“Thinking of ordering take out- there’s a binder that has menus, numbers and shit of local places that deliver.”
Billy deflated a little as Eddie got out of bed and swiped the binder from the dresser.
“We’ve had enough junk food, babe,” he pointed out, his stomach still grumbling, unsatisfied with the jerky.
Eddie flicked on the light above the headboard of the bed, and pointed to a page in the binder.
“Look. Local seafood- shrimp, fish, crab, pasta, crab cakes…”
Billy’s stomach let out a roar and Eddie laughed as his own stomach echoed the sentiment.
“Yeah, fish and chips sounds amazing.”
“Actual seafood, locally caught,” Billy breathed. “Fuck, that sounds so good.”
Eddie grinned.
“You order for us- I’m gonna take a shower because I caught a whiff of my own pits and I reek. You can join me after you order us some food, and by the time we’re done, it’ll be here, and we can go eat it on the beach.”
Billy smiled.
“That sounds amazing. Fish and chips, then?”
“Yeah, with extra lemon, ketchup instead of tartar sauce, and a sweet tea with lemon.”
Eddie kissed Billy’s forehead, then disappeared into the bathroom while Billy ordered their dinner- Eddie’s fish and chips, and a basket of fried mahi mahi, grilled salmon, fried shrimp, and a large order of french fries, with two large cokes. He suspected Eddie would want to sample from his plate, as he was wont to do, and he decided if Eddie was going to sample some of his seafood, there would be good seafood, and plenty of it.
Billy waited for Eddie to finish showering before taking one himself. He still had issues being seen in full light, still needed to be alone when he had to touch his scars.
Eddie was patient in that regard. He never asked Billy to take showers together, never demanded bright lights when they were intimate. Billy was getting better, though- he could handle a lamp or two being on, and didn't flinch anymore when Eddie's hands brushed over his scars.
It was different in a shower, when he was naked and there was no expectation of intimacy to distract Eddie from his scars. He felt too exposed, too vulnerable.
Eddie was okay with that. He'd wait as long as it took, as long as Billy needed, to be comfortable in his own skin again.
The food arrived after an hour- Eddie was ravenous, but didn't begrudge the delivery guy for the wait, tipping him well. The bag of food had steam billowing from the seams, and it was hot in his hands. The drinks were still cold and full of ice, the plastic cups beaded in condensation.
Billy came out, wearing swim trunks and a tank top, drying his hair with a towel. He sniffed the air and his stomach let out a roar. Eddie grinned and held up the bag.
“Dinner's here!”
Billy headed for the table, but Eddie shook his head, shoving his feet into his Reeboks.
“Come on,” he said, grabbing the throw blanket from the end of the bed. “Get the drinks, let's go eat this on the beach.”
Billy's face lit up, and he slipped into his flip-flops, grabbing the drinks and the room key. Together, the locked the room up, and headed for the beach.
The sun was setting, and there weren't many people around. The surf was loud, soothing, and the sky was a rich gradient of gold, orange, red, wine, and dark indigo blue, with a splattering of stars starting to shine through. On the horizon, Billy could see sparks of light that he knew were Mars and Venus.
Eddie spread out the blanket on a soft, level patch of sand just far enough from the waterline that they wouldn't get wet, but close enough that it was only a few steps to get his feet in the water.
The two of them sat down, pulling out their dinner and setting it out. Though they'd ordered their own meal, they shared, eating in companionable silence only broken by commentary on the food, or soft laughter or sounds of appreciation.
Eddie felt flustered as occasionally, Billy held out morsels for him to try, refusing to let Eddie take them with his hands- he put them directly in Eddie's mouth, his eyes glittering in the light of the fading sunset, love and gratitude written all over his face.
“I needed this. So much.”
Eddie wiped grease off on his jeans and reached over to take Billy's hand, squeezing it.
“I know. Was it a good surprise?” he asked.
Billy nodded, his eyes shining, and he looked over the water. The sunset was almost gone, a thin sliver of gold and red shining over the edge of the horizon, casting an orange light over the water in stark contrast with the wine-dark ocean and the sparkling stars overhead.
”I don't think it could get any better,“ he said softly.
”Maybe if you could surf?“ Eddie suggested, and Billy shook his head, squeezing Eddie's hand again.
”Tomorrow. For now? This is all I need.“
He leaned in to kiss Eddie, and a massive splash of water caught their attention.
Out of the water, the remaining sunlight shining on its slick rubbery skin, leapt a massive killer whale. It let out the breath from its lungs in a great burst of air before crashing back into the water again.
Billy was on his feet, running for the tide, Eddie following. Billy went as far as waist deep, staring at the water with eyes wide.
“Billy?”
Billy didn't answer. The orca breached again, this time, his belly facing them, his massive, elegant body twisting as he leapt for the sheer joy of it, as if trying to fly, and not caring if he succeeded- because the attempt was all that mattered.
Tears rolled down his face as he saw the freckles on the white parts of the orca's chin and belly- the very same he'd seen on a calf nearly a decade ago.
“You made it,” he whispered. “You grew up.”
Eddie was in the water beside him, his arm around his waist. The water was cold around their legs, the sand fine and coarse under their feet, between their toes, swirling in the tide.
“You… you know this whale?” Eddie joked gently. “He owe you money for a surfing contest, because it looks like he'd win.”
Billy laughed, pulling Eddie against him, not bothering to wipe the tears from his face.
“I saw him when I was ten. I was surfing, and this calf just leaps out of the water, and I saw a freckle on his belly, on his jaw. He was the spunkiest, happiest thing I'd ever seen in my life.”
Billy smiled. A real, genuine smile.
“I dreamt about him when I was in a coma. About coming home, and seeing him again. And here he is, all grown up. He's HUGE, he's powerful and he's still free and happy.“
Another splash, a short distance away, and another orca leapt out of the water. This one was a bit smaller, with a shorter dorsal fin- and there was a calf at its side. Billy's smile grew.
”Is that your kid, big guy?“ Billy asked the orca, even if he couldn't hear the question. ”Did you find a family of your own?“
One by one, more orcas began to join the acrobatics, and soon, there was close to ten of them, all leaping, breaching, splashing with their tails, rolling in the water, playing with the calves, and high pitched calls sounded over and through the water as they talked to one another.
Billy turned and buried his face in Eddie's chest, his shoulders shaking, tears soaking Eddie's shirt. Eddie held him close, alarmed.
”Billy, you okay?“ he asked, worried.
”I'm better than okay,“ Billy managed.
Eddie held him, waiting for him to recover, to regain his composure. When Billy pulled away again, he was smiling.
”They're welcoming me home, Eddie.“
”Yeah, you really do belong here,“ Eddie agreed, thinking they needed to make this trip permanent, that they needed to move here for Billy's well being. Already, his mind was making plans, lists, mapping out the move and the logistics behind it.
Billy shook his head.
”I wouldn't have come here, wouldn't have seen them, wouldn't have had this chance at recovering, if it wasn't for you, Eddie,“ he said.
He rested his head on Eddie's shoulders, letting the waves crash against his waist, feeling the sand under his feet, watching the orcas dance.
”Me?“ Eddie asked, and Billy nodded.
”It's you, Eddie. Wherever you are, is home.“
Eddie swallowed a shuddering, happy breath, resting his cheek against Billy's head, and the two of them watched the orcas dance under the stars.
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It's very cute that Mr. Mega thinks his refusal to read our leaks means anything. We'll continue sharing them, and people will continue reading them. But here, for you, Mr. Curt Mega, we have provided the medical report from John's time in the hospital after the ten days of sleeplessness he spoke of. Thank us later!
Mount Sinai Hospital Treatment Report: Johnathan S. MacNamara
Date of Admission: September 9, 2012
Date of Discharge: November 17, 2012
The patient was admitted to the Emergency Room at 6:24 AM, 09/05/12 and evaluated to be in critical condition almost immediately. He exhibited signs of septic shock, including: lung failure, kidney failure, liver failure, a blood pressure of 68/43 mm Hg, and a heart rate of 134 BPM. In addition, he showed signs of infection stemming from an abdominal laceration approximately 30 inches in length and on average approximately 2 inches deep. The exhibited signs included: seizures, a consistent 105° F fever, swelling around the wound, pus in and around the wound, and human fecal matter smeared across the abdominal region. The lattermost sign was not so much a symptom as an obvious cause.
The patient's wounds were immediately cleaned with heavy disinfectants and a tracheostomy was preformed. He was attached to a mechanical ventilator and the blood-oxygen levels slowly stabilized. Patient was admitted to the ICU for further treatment at 7:36 PM, 09/05/12. Injuries upon admission were mapped as follows:
1. Bullet entry and exit through right deltoid. 2. Large laceration across midsection. Shows signs of heavy bacterial and viral infection. 3. Second-degree burn in the shape of greek letter omega. 4. Electric burns on lower right back. Presumably from high-voltage taser or cattle prod. 5. Intense electric burns in genital and inner-thigh areas. 6. Hamstrings lacerated. Presumably to constrict movement of legs.
Upon admission to the ICU, the patient was administered a standard dose of penicillin. There had been no signs of consciousness since arrival to the hospital, however the patient did appear to be in a survivable state. Within the unit, he was attached to a dialysis machine and given a steady IV of saline solution and another one that contained water-soluble vitamins and nutrients. Once the infection showed no further sign of spreading, the patient was given an emergency liver transplant. This occurred on 09/06/12.
The transplant succeeded, and the liver immediately began to filter blood and further cleared the infection. The decision was made to keep the patient on the dialysis machine until the infection and subsequent sepsis was cleared, and after a partial recovery from the first transplant occurred.
After 57 hours of total unconsciousness and unresponsiveness, the patient was declared to be in a coma caused by toxic-metabolic encephalopathy. He was assumed to wake up within the month.
The tracheostomy ventilator was removed on 09/23/12 and replaced with a laryngoscopic ventilator. This was changed once more on 10/03/12 when it was replaced with a mask ventilator.
The genital burns required a skin graft, but otherwise healed normally without infection or complications.
At 1:58 PM on 10/09/12, the patient began to react to outside stimuli. He moved when touched and made audible responses to pain. Over the next few days, he began to react to auditory and olfactory stimuli in addition to touch-based reactions increasing in consistency. By 10/12/12, the patient could follow simple commands and had managed to open his eyes a few times.
On 10/15/12 at approximately 12:30 AM, the patient awoke in a frenzied state. He attempted to rip out IVs and pulled off the ventilation mask and appeared to be unaware of where he was. It took excessive physical force, but he was eventually restrained and slowly calmed. He fell back asleep soon after, but showed greater signs of healing by that point. The next afternoon, he gave an official record of what happened to him, which provided a more accurate method of how to treat him. He consented to a kidney transplant and went into surgery on 10/18/12.
There were no complications during the surgery, and the donor was the wife of the patient, Rosalind M. Schaffer. She didn't suffer any complications from the donation either.
After the surgery, he was moved from the ICU and into the recovery wing with a private room.
The patient was dosed on standard pain medication over recovery, and showed no infectious flare-ups over recovery. He was monitored for lasting impacts of his wounds or disease, and had gained a noticeable tremor in both his hands. He underwent physical therapy while in the hospital's care, allowing him to regain full motion in his legs and to lessen his hand tremors.
The patient was discharged at 8:14 PM on 11/17/12 with a clean bill of health and prescribed a pain medication for as long as needed. It was also recommended that the patient stop smoking, as his lungs had previously failed once and it could be a major risk factor. The patient obviously did not follow the advice, as he was seen smoking a cigarette the second he left hospital grounds.
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Jess Watches // Sun 12 May // Day 228 Synopses & Favourite Scenes & Poll
The Resident (with mum) 3x10 Whistleblower (mid season break)
On Devon's last day as an intern, he and Conrad are faced with a moral dilemma over a suicidal patient who is in need of a liver transplant. When Bell discovers that Cain is keeping braindead patients alive in order to boost his survival rates and add to Red Rock's profits, he decides to take matters into his own hands. Meanwhile, Adaku goes into early labor, causing a strain on her heart and Mina is left in doubt over how to best handle her care.
You just knew Conrad wasn't gonna make it to the end of his shift without being caught. Red Rock pounced. Hopefully Conrad's dad helps defeat them. How smug they were to demote Bell, but him being more focused on making sure Kit gets to keep her job. And I hope Adaku and baby are ok.
Star Trek: Prodigy 1x14 Crossroads
When the crew attempts to secure transport to the Federation, they unwittingly cross paths with the Vice Admiral who is hunting them.
I like that Starfleet aren't clean cut 'good guys'. They seem to be thriving on the power afforded to them by the Federation and the story is building effectively to show how dangerous that can be.
Amphibia 1x12 Civil Wart / Hop-Popular
Anne exposes Wartwood to a teen romance film, and the town is split on the movie's love triangle. / After losing his stand, Hop Pop decides to run for mayor of Wartwood.
Shipping wars are serious business in Wartwood. Sequel Plot Twist: the boys are in love too! I had a good giggle at the end with not-so-subtle references to fandom culture. / And being a theatre major, Hop Pop would be a marvellous mayor.
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The targeting practices make this so much worse. I was diagnosed with liver disease a few years ago and eventually got on the transplant list, so during that I was googling a lot of medications and symptoms and survival rates. Apparently the algorithms associate liver with alcohol and I started getting alcohol ads constantly. What if I was an alcoholic? Who's blamed if someone goes back to an addiction because of those constant reminders?
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The Sirolimus market is anticipated to expand from $1.5 billion in 2023 to $3.2 billion by 2033, reflecting a robust CAGR of 7.8%, driven by increasing demand.
Sirolimus Market : Sirolimus, a potent immunosuppressive drug, is transforming the treatment of organ transplant recipients and patients with certain cancers. By inhibiting the immune system’s response, sirolimus helps prevent organ rejection after transplants, such as kidney or liver transplants, ensuring the body doesn’t attack the new organ. Additionally, this drug has shown promise in treating certain types of cancer, like renal cell carcinoma, by interfering with tumor growth. Its targeted action not only improves graft survival rates but also reduces the need for higher doses of corticosteroids, which can have harsh side effects. Sirolimus offers a critical balance in transplant medicine by managing immune responses while reducing adverse effects.
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As research continues to expand, sirolimus is being explored for its potential in treating a range of autoimmune disorders, including those with vascular and connective tissue conditions. The flexibility of sirolimus in managing both cancer and organ transplant care positions it as a valuable therapeutic tool in modern medicine. By providing better outcomes for patients with chronic conditions or those undergoing life-saving procedures, sirolimus is helping to reshape the future of immunosuppressive therapies. As new formulations and delivery methods emerge, sirolimus may continue to improve patient quality of life and expand its role in immune modulation.
#Sirolimus #ImmunosuppressiveTherapy #OrganTransplant #CancerTreatment #KidneyTransplant #RenalCellCarcinoma #Immunology #TransplantCare #MedicalInnovation #CancerCare #VascularDiseases #AutoimmuneDisorders #HealthTech #TargetedTherapy #PatientCare
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What Are the Stages of Liver Cancer? Comprehensive Guide to Diagnosis and Progression
Liver cancer is a complex disease that unfolds over several stages. Understanding these stages is crucial for effective treatment and care. This guide provides a deep dive into the stages of liver cancer, focusing on how the disease is diagnosed and progresses. Our goal is to equip you with a comprehensive overview of liver cancer's stages, from early diagnosis to the advanced stages, ensuring patients, caregivers, and healthcare professionals are well-informed.
What Is Liver Cancer? An Overview
Liver cancer originates in the liver cells, with hepatocellular carcinoma (HCC) being the most common type. Other types include intrahepatic cholangiocarcinoma and angiosarcoma. Identifying the specific type is critical, as each progresses differently and requires tailored treatment. Early diagnosis and intervention significantly improve outcomes, making awareness of liver cancer's progression essential.
Symptoms and Early Detection of Liver Cancer
The symptoms of liver cancer can vary widely, especially in its early stages. Some common symptoms include:
Unexplained weight loss
Persistent pain in the upper abdomen
Swelling or bloating
Yellowing of the skin and eyes (jaundice)
While these symptoms can indicate various conditions, they become critical signals for liver cancer screening when they persist. Detecting liver cancer early, before it spreads, significantly enhances treatment options and effectiveness.
The Importance of Staging in Liver Cancer Treatment
In liver cancer, staging is used to describe the size, spread, and extent of the disease. Understanding the stage of liver cancer is essential for doctors to design a personalized treatment plan. This staging system provides a snapshot of how advanced the cancer is and informs decisions on surgery, chemotherapy, radiation therapy, and other treatments.
The Liver Cancer Staging Systems
Liver cancer is staged using different systems, with two primary frameworks widely accepted:
The American Joint Committee on Cancer (AJCC) TNM System: This system considers Tumor (T) size, lymph Nodes (N) involvement, and Metastasis (M) to classify the cancer stage.
The Barcelona Clinic Liver Cancer (BCLC) Staging System: This system incorporates tumor characteristics, liver function, performance status, and treatment recommendations.
For a comprehensive approach, let's delve into each stage, examining how liver cancer progresses.
Stage I: Localized Liver Cancer
In Stage I, the cancer is still contained within the liver. It is typically a small tumor without any invasion into nearby blood vessels or lymph nodes. At this stage, liver cancer may not show noticeable symptoms, and it is often detected through routine imaging tests or liver function tests.
Characteristics: Single tumor, no blood vessel invasion.
Treatment Options: Surgical resection, ablation, or liver transplantation may be possible.
Prognosis: Early-stage liver cancer has a higher survival rate due to the limited spread.
Stage II: Cancer Begins to Spread Within the Liver
In Stage II, liver cancer begins to show signs of spreading. One or more tumors may be present, and cancer may start to invade nearby blood vessels. However, it is still localized within the liver.
Characteristics: Multiple small tumors or a single tumor with blood vessel involvement.
Treatment Options: Surgical resection or localized treatments like radiofrequency ablation and embolization.
Prognosis: Early intervention still offers a good prognosis, but monitoring is critical as the risk of spread increases.
Stage III: Advanced Liver Cancer in the Liver
In Stage III, liver cancer has advanced within the liver, affecting larger portions or multiple areas of the liver. This stage is divided into three subcategories:
Stage IIIA: Multiple large tumors or a single tumor that has invaded a major blood vessel.
Stage IIIB: Tumors have spread to nearby organs (excluding the gallbladder) or the liver’s outer layer.
Stage IIIC: Cancer has spread to nearby lymph nodes.
Treatment Options: Targeted therapies, chemotherapy, and palliative care. Surgery may not be an option if the cancer has spread significantly.
Prognosis: The prognosis at this stage is more challenging, but treatments focus on slowing progression and managing symptoms.
Stage IV: Metastatic Liver Cancer
Stage IV represents the most advanced phase of liver cancer, where the disease has metastasized, spreading beyond the liver to other parts of the body such as the lungs, bones, or other organs. This stage is often further classified into IVA and IVB:
Stage IVA: Cancer has spread to distant lymph nodes.
Stage IVB: Cancer has spread to other organs beyond the liver.
Characteristics: Metastasis to multiple organs, distant lymph nodes, and tissues.
Treatment Options: Systemic treatments such as chemotherapy, immunotherapy, and palliative care to manage symptoms and improve quality of life.
Prognosis: The prognosis is often poor due to the extensive spread, but treatments aim to manage symptoms and improve the patient's comfort and quality of life.
How Is Liver Cancer Diagnosed? Essential Tests and Procedures
Detecting liver cancer requires a combination of imaging studies, lab tests, and sometimes biopsies. The primary diagnostic tools include:
Ultrasound: Initial imaging for any suspected liver abnormalities.
CT Scan and MRI: Provide detailed images to assess the size and spread of tumors.
Biopsy: A tissue sample may be taken to confirm the presence and type of cancer.
Blood Tests: Markers like alpha-fetoprotein (AFP) can suggest liver cancer when elevated.
Early and accurate diagnosis is essential for effective treatment planning, and regular screenings are recommended for individuals at high risk of liver cancer, such as those with chronic hepatitis or cirrhosis.
Treatment Options Across Stages
Stage-Dependent Treatments: Liver cancer treatment varies by stage. Surgical options are often viable in earlier stages, while later stages may focus on systemic treatments and palliative care.
Surgical Resection: Removing part of the liver affected by cancer.
Liver Transplant: Suitable for patients with limited cancer spread.
Localized Therapies: Ablation, embolization, and radiation are often used in early to mid-stages.
Targeted Therapy and Immunotherapy: Used in advanced stages to slow cancer growth and enhance the immune response.
Each treatment plan is highly individualized, taking into account the stage, liver function, and overall health.
Risk Factors and Prevention
The risk factors for liver cancer include chronic hepatitis B or C infection, alcohol-related liver disease, nonalcoholic fatty liver disease, and certain genetic conditions. Preventative measures include:
Regular Screenings: For high-risk individuals.
Vaccination: Against hepatitis B.
Lifestyle Adjustments: Reducing alcohol intake, maintaining a healthy weight, and managing liver conditions.
Living with Liver Cancer: Support and Resources
Managing liver cancer requires comprehensive support, from medical treatment to emotional and psychological care. Patients benefit from a strong support network, access to counseling, and community resources that provide assistance and guidance throughout treatment and recovery.
Conclusion: Navigating Liver Cancer Stages and Treatment
Liver cancer presents unique challenges, but understanding its stages empowers patients and their families to make informed decisions. From early detection to advanced care, awareness and timely intervention can make a significant difference. For those diagnosed, working closely with a healthcare team is essential to explore all treatment options, manage symptoms, and maintain quality of life.
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Liver Cancer Treatment Survival Rate
The 5-year survival for liver cancer treatment is approximately 10%-14%, low in part because many of the patients with liver cancer also have cirrhosis, which is a serious liver disease in its own right. The dual entity of cirrhosis-liver cancer together poses a very dangerous combination. Regular screening for high-risk patients (e.g., those with chronic hepatitis B or C infection) will allow earlier disease detection and optimal treatment. Early diagnosis of this cancer generally equates with improvement in survival chances. the 5-year survival rate can be over 50% in patients free from cirrhosis or other serious health issues. The transplanted liver can survive for 60-70% of patients within the 5-year survival range in cases of early-stage liver cancer.
For more information about liver cancer treatment click on the below link:
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The Risks and Benefits of Liver Transplant Surgery
Liver transplant surgery is often a life saving option for people with severe liver diseases, such as cirrhosis, hepatitis, or liver cancer. This complex procedure involves replacing a diseased liver with a healthy one, often from a deceased or living donor. Though liver transplantation is widely practiced, patients should carefully consider both the risks and benefits of the surgery, ideally in consultation with a skilled professional
Benefits of Liver Transplant Surgery
Life-Saving Potential: For patients in advanced stages of liver disease, a transplant can mean the difference between life and death. A new liver can reverse the effects of liver failure, restoring vital functions like blood filtration, metabolism, and immunity.
Improved Quality of Life: Many patients who undergo liver transplants find a significant improvement in their daily life. Physical symptoms associated with liver disease, such as jaundice, muscle weakness, and chronic fatigue, are often alleviated after a successful transplant. With a healthy liver, patients can regain strength, return to work, and participate in family and social activities.
Reduced Risk of Liver Cancer Recurrence: For some patients with liver cancer, a transplant may offer a better long-term solution than traditional treatments, such as chemotherapy or partial liver resection. With the diseased liver removed, the likelihood of cancer recurrence can be significantly reduced, providing a potentially cancer-free future.
Long Term Health Benefits: A successful transplant can provide long-term health benefits, allowing recipients to live healthier lives for years. Advances in surgical techniques and post-transplant care have improved survival rates, making transplants a viable option for those with end-stage liver disease.
Risks of Liver Transplant Surgery
Surgical Complications: The liver transplant surgeon in indore is complex and involves the risk of complications during or after the procedure. Potential complications include bleeding, bile duct issues, and blood clot formation. While highly skilled surgeons, such as those among the best liver specialists in Indore, can minimize these risks, they remain a possibility in any major surgery.
Rejection of the Donor Liver: The immune system may recognize the new liver as foreign and attempt to reject it. To prevent this, patients need lifelong immunosuppressive medications, which reduce the risk of rejection but can have side effects, including an increased susceptibility to infections and certain cancers.
Infections: Immunosuppressive drugs, essential to prevent rejection, also weaken the body's defense mechanisms, making patients more prone to infections. Infections can occur in various body parts, such as the lungs, urinary tract, and surgical incision site. Ensuring a clean, supportive recovery environment is vital to manage this risk.
Mental and Emotional Stress: The journey through a liver transplant can be mentally and emotionally taxing for both the patient and their loved ones. From managing post surgery medications to adjusting to a new lifestyle, the transplant process can be challenging. Psychological support and counseling can help patients and families adapt and find stability.
A liver transplant is a critical procedure with the potential to extend and improve the lives of those with severe liver disease. Understanding the risks and benefits can help patients make informed decisions, ideally with a liver transplant surgeon's guidance or the best liver specialist in Indore. With the right medical support and a commitment to post-operative care, patients can navigate the complexities of a liver transplant, embracing a second chance at life.
#liver transplant surgeon in indore#liver specialist in indore#best liver doctor in indore#best liver specialist doctor in indore#liver doctor in indore#liver doctor indore#liver specialist dr in indore
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Dr. Ganesh Nagarajan: Liver Cancer Treatment in Mumbai
Liver cancer is one of the most serious and life-threatening forms of cancer. As with most cancers, early detection and effective treatment are key to improving survival rates. For patients in India, particularly in Mumbai, access to top-tier liver cancer care is essential. Dr. Ganesh Nagarajan, a renowned surgical oncologist, provides crucial insights into the causes, symptoms, and treatment options available for liver cancer. His expertise has made him a trusted figure in Liver Cancer Treatment in Mumbai, helping many patients navigate this difficult diagnosis.
Understanding Liver Cancer: An Overview
Liver cancer occurs when cells in the liver begin to grow uncontrollably, forming a malignant tumor. There are different types of liver cancer, the most common being hepatocellular carcinoma (HCC), which originates in the main type of liver cells. Less commonly, cancer can begin in the bile ducts or blood vessels within the liver.
In most cases, liver cancer does not show any noticeable symptoms in the early stages. By the time it is diagnosed, the disease may have already progressed to an advanced stage. Dr. Ganesh Nagarajan emphasizes the importance of regular screening, especially for those with risk factors like chronic hepatitis or cirrhosis, as it could lead to early detection and more effective liver cancer treatment in Mumbai.
Causes and Risk Factors of Liver Cancer
Dr. Ganesh Nagarajan explains that liver cancer is primarily associated with chronic liver conditions. Some of the most common risk factors include:
Chronic Hepatitis B and C: Both hepatitis B and C are viral infections that lead to liver inflammation. Over time, this inflammation can cause cirrhosis, which significantly increases the risk of developing liver cancer.
Cirrhosis: This is a condition where scar tissue gradually replaces healthy liver tissue, impairing liver function. Cirrhosis can result from various factors, including long-term alcohol abuse, fatty liver disease, and chronic viral hepatitis.
Alcohol Consumption: Excessive alcohol intake is another leading cause of liver cancer. Over time, it can lead to cirrhosis, which heightens the risk of cancerous cell formation.
Non-Alcoholic Fatty Liver Disease (NAFLD): As obesity and type 2 diabetes become more common, so does NAFLD. This condition can lead to liver inflammation, scarring, and, ultimately, cancer.
Exposure to Aflatoxins: These harmful substances, produced by fungi found in crops, particularly grains and nuts, have been linked to liver cancer.
Symptoms of Liver Cancer
As Dr. Ganesh Nagarajan explains, liver cancer is often referred to as a "silent" disease because its symptoms may not appear until it has reached an advanced stage. Some common symptoms that may indicate liver cancer include:
Unexplained weight loss
Loss of appetite
Upper abdominal pain
Jaundice (yellowing of the skin and eyes)
General weakness and fatigue
Nausea and vomiting
For anyone experiencing these symptoms, seeking an expert opinion from a specialized clinic offering liver cancer treatment in Mumbai is critical. Early diagnosis and immediate treatment offer the best chance of success.
Treatment Options for Liver Cancer
Dr. Ganesh Nagarajan emphasizes that liver cancer treatment in Mumbai varies based on the stage of cancer, overall liver function, and the patient’s health. Some of the most common treatment options include:
Surgery: If the tumor is small and localized, surgical resection can be performed to remove the cancerous part of the liver. In certain cases, a liver transplant may also be considered.
Ablation and Embolization: For patients who are not suitable candidates for surgery, techniques such as radiofrequency ablation (RFA) or transarterial chemoembolization (TACE) can be used to destroy cancer cells or block blood flow to the tumor.
Targeted Therapy: This treatment involves using drugs that specifically target cancer cells while sparing normal cells, helping to slow the progression of the disease.
Chemotherapy: While liver cancer is often resistant to chemotherapy, it may still be used in some cases to shrink tumors or slow their growth.
Immunotherapy: A newer form of treatment, immunotherapy works by stimulating the immune system to attack cancer cells.
Conclusion
Liver cancer remains a challenging diagnosis, but with advances in medical treatments, there is hope. For those in need of liver cancer treatment in Mumbai, Dr. Ganesh Nagarajan's clinic offers expert care and cutting-edge therapies designed to give patients the best possible outcome. With a focus on individualized treatment plans, he is a trusted resource for anyone facing this difficult disease.
FAQs
1. What are the early warning signs of liver cancer?Early-stage liver cancer may not show symptoms, but common signs include weight loss, abdominal pain, and jaundice.
2. Is liver cancer curable?If detected early, liver cancer can be treated effectively, especially through surgery or liver transplant.
3. Who is at risk of developing liver cancer?Individuals with chronic liver diseases, hepatitis B or C, cirrhosis, or excessive alcohol use are at higher risk.
4. How can liver cancer be prevented?Preventive measures include hepatitis vaccinations, limiting alcohol intake, maintaining a healthy weight, and regular screenings for those at risk.
5. Why is Dr. Ganesh Nagarajan considered an expert in liver cancer treatment?Dr. Ganesh Nagarajan is a renowned surgical oncologist in Mumbai, specializing in advanced techniques for treating liver cancer, offering personalized treatment plans for each patient.
For expert Liver Cancer Treatment in Mumbai, consult with Dr. Ganesh Nagarajan and get the best care possible.
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Treatment Of Liver Cirrhosis Market To Grow At Highest Pace Due To Rising Alcohol Intake
Liver cirrhosis refers to scarring (fibrosis) of the liver tissue and poor functioning of the liver. It is caused by excessive alcohol consumption over many years or due to chronic hepatitis virus infections such as hepatitis B or C. The progression of fibrosis leads to nodule formation and ultimately to cirrhosis. The key symptoms of liver cirrhosis include jaundice, fatigue, abdominal pain, weakness, loss of appetite, nausea and vomiting. Treatment for liver cirrhosis depends on the severity of the disease and includes medications to improve liver functions, antibiotics to treat infections, diuretics to remove excess fluid and sometimes orthotopic liver transplantation.
The Liver Cirrhosis Market is estimated to be valued at US$ 1.41 Bn in 2024 and is expected to exhibit a CAGR of 5.2% over the forecast period 2024-2031.
Key Takeaways
Key players operating in the liver cirrhosis market are Madrigal Pharmaceuticals, Inc., Galectin Therapeutics Inc., Grifols Therapeutics LLC, Cyma Bay Therapeutics, Akero Therapeutics, Inc.
Key players operating in the liver cirrhosis market are increasingly investing in R&D to develop advanced treatment options. For instance, Madrigal Pharmaceuticals is developing resmetirom, a first-in-class thyroid hormone receptor beta-selective agonist for the treatment of non-alcoholic steatohepatitis (NASH) and liver cirrhosis.
The growing prevalence of excessive alcohol consumption and obesity are major factors fueling the demand for liver cirrhosis treatment solutions. According to WHO, around 3 million deaths each year result from harmful use of alcohol. Excessive alcohol intake damages liver cells making the organ less able to regenerate, leading to the development of cirrhosis over the years.
Technological advancements in liver transplantation techniques coupled with the emergence of effective post-transplant medications have increased the eligibility of patients and survival rates post transplantation. Shortage of liver donors however remains a key challenge. Companies are investing in development of artificial or bio-engineered livers as potential alternatives.
Market Trends
Increasing Adoption Of Targeted Therapies: Pharma companies are focusing on developing targeted therapies for liver cirrhosis that specifically act on certain molecular targets or pathways involved in disease progression. For example, Galectin Therapeutics' drug belapectin blocks galectin-3 activity involved in fibrotic response and necrosis.
Rise Of Combination Therapies: Due to multifactorial nature of the disease, companies are exploring efficacy of combining two or more treatment modalities for synergistic effects. For example, combination of antiviral medications with immunomodulators to achieve sustained virologic response.
Market Opportunities
Asia Pacific presents high growth prospects owing to changing lifestyles, abusive consumption of alcohol and growing obesity rates. Public-private partnerships can help facilitate more affordable healthcare access in emerging economies.
Emergence of non-invasive diagnostic tools leveraging imaging and biomarkers hold potential to precisely diagnose and monitor disease progression and treatment response without need for repeated liver biopsies. This can increase patient acceptance and compliance.
Impact Of COVID-19 On Liver Cirrhosis Market Growth
The COVID-19 pandemic has significantly impacted the growth of the liver cirrhosis market. During the initial phases of the pandemic, factors like lockdowns, restrictions on non-essential medical services led to postponement of diagnosis procedures and delay in treatment. This adversely impacted the market growth initially. However, as the healthcare sector learned to cope and adapt to the new normal, telehealth services gained prominence helping maintain continuity of care virtually. With the development and availability of vaccines as well, the market is recovering fast. However, challenges like availability of medical staff, hospital beds, and potential risks of severe COVID infection in cirrhosis patients still persist and need to be addressed. The immediate focus post pandemic is to boost diagnosis and treatment rates back to pre-COVID levels. Intensifying awareness campaigns and policies promoting community healthcare can aid in early detection and management of cirrhosis cases.
Geographical Regions With Highest Liver Cirrhosis Market Value
North America dominates the Liver Cirrhosis Market in terms of value. The region accounted for over 35% market share in 2024 owing to rising prevalence of cirrhosis caused by non-alcoholic steatohepatitis (NASH) and alcohol abuse. Growing healthcare spending and availability of advanced treatment options have further augmented the regional market. Europe ranks second with major markets being Germany, United Kingdom, France and Italy. Developed healthcare infrastructure, supportive reimbursement environment and presence of key industry players have boosted the European market.
Fastest Growing Region For Liver Cirrhosis Market
Asia Pacific is identified as the fastest growing regional market for liver cirrhosis expected to expand at a CAGR of around 7% during the forecast years. Growing consumption of alcohol, rising obesity rates attributed to changing lifestyles and dietary habits have majorly contributed to increased cirrhosis burden in the region. Countries like China, India and Japan have emerged as high potential markets. Rapid economic development, rising healthcare expenditure, growing medical tourism are some factors favoring the Asia Pacific liver cirrhosis market. Initiatives to spread awareness about lifestyle-related liver diseases can further augment the regional market opportunities.
Get more insights on this topic: https://www.trendingwebwire.com/liver-cirrhosis-market-poised-for-growth-amid-rising-adoption-of-targeted-therapies/
Author Bio:
Alice Mutum is a seasoned senior content editor at Coherent Market Insights, leveraging extensive expertise gained from her previous role as a content writer. With seven years in content development, Alice masterfully employs SEO best practices and cutting-edge digital marketing strategies to craft high-ranking, impactful content. As an editor, she meticulously ensures flawless grammar and punctuation, precise data accuracy, and perfect alignment with audience needs in every research report. Alice's dedication to excellence and her strategic approach to content make her an invaluable asset in the world of market insights. (LinkedIn: www.linkedin.com/in/alice-mutum-3b247b137 )
What Are The Key Data Covered In This Liver Cirrhosis Market Report?
:- Market CAGR throughout the predicted period
:- Comprehensive information on the aspects that will drive the Liver Cirrhosis Market's growth between 2024 and 2031.
:- Accurate calculation of the size of the Liver Cirrhosis Market and its contribution to the market, with emphasis on the parent market
:- Realistic forecasts of future trends and changes in consumer behaviour
:- Liver Cirrhosis Market Industry Growth in North America, APAC, Europe, South America, the Middle East, and Africa
:- A complete examination of the market's competitive landscape, as well as extensive information on vendors
:- Detailed examination of the factors that will impede the expansion of Liver Cirrhosis Market vendors
FAQ’s
Q.1 What are the main factors influencing the Liver Cirrhosis Market?
Q.2 Which companies are the major sources in this industry?
Q.3 What are the market’s opportunities, risks, and general structure?
Q.4 Which of the top Liver Cirrhosis Market companies compare in terms of sales, revenue, and prices?
Q.5 Which businesses serve as the Liver Cirrhosis Market’s distributors, traders, and dealers?
Q.6 How are market types and applications and deals, revenue, and value explored?
Q.7 What does a business area’s assessment of agreements, income, and value implicate?
*Note: 1. Source: Coherent Market Insights, Public sources, Desk research 2. We have leveraged AI tools to mine information and compile it
#Liver Cirrhosis Market Trend#Liver Cirrhosis Market Size#Liver Cirrhosis Market Information#Liver Cirrhosis Market Analysis#Liver Cirrhosis Market Demand
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Alcoholic Liver Diseases: Symptoms, and Treatment
Overconsumption of alcohol over time can lead to alcoholic liver disease. This condition not only causes liver damage but also results in the buildup of fats, inflammation, and scarring. In alcoholic liver disease, healthy liver tissues are replaced with scarred tissues. It’s a major cause of acute liver damage and can lead to liver failure, sometimes necessitating a liver transplant. Liver damage due to alcohol typically occurs in three stages: fatty liver, alcoholic hepatitis, and cirrhosis.
Early Signs
The early signs of alcoholic liver disease are often subtle and can affect various systems in the body. Early symptoms may include:
Nausea and vomiting
Abdominal pain
Reduced appetite
Diarrhea
These early symptoms are often mistaken for general malaise or a stomach bug. Ignoring these symptoms can lead to faster progression of the disease.
Alcoholic Liver Disease Symptoms
As the disease progresses, symptoms become more noticeable and severe. Later-stage symptoms include:
Swelling of the lower limbs (oedema)
Ascites (buildup of fluid in the abdomen)
Jaundice (yellowing of the skin and eyes)
Fever and shivering
Weight loss
Itchy skin
General weakness and muscle wasting
Excessive curvature of fingernails
Blood in stools and vomit
Easy bruising and bleeding
Increased sensitivity to drugs and alcohol
If you experience these symptoms, it’s crucial to consult a doctor at a reputable liver care hospital.
Treatment Options for Alcoholic Liver Disease (ALD)
Abstinence The most crucial treatment for ALD is complete abstinence from alcohol. This reduces further liver damage and allows the liver to recover, improving outcomes and the histological features of hepatic injury. Abstinence helps improve survival rates at all stages of ALD.
Nutritional Therapy Malnutrition is a common consequence of ALD, especially in the second stage of alcoholic hepatitis. Protein-calorie malnutrition is prevalent in patients with ALD. No matter the stage, consulting a hepatologist and starting nutritional therapy early can help alleviate symptoms and improve the condition.
Medication (Pharmacological Therapy) Hepatologists carefully screen the symptoms and stages of the disease to prescribe appropriate medications. Patients must adhere to their medication regimen to improve symptoms.
Liver Transplant In severe cases, liver transplant surgery may be the only option. This step is taken when the liver has completely stopped functioning and there’s no improvement despite abstinence from alcohol. Complicated cirrhosis and lack of response to other treatments, including medications, may necessitate a liver transplant. Patients must also lose weight and quit smoking, as both can worsen ALD.
Conclusion
Alcoholic liver disease is a serious condition that requires timely diagnosis and treatment. Early signs may be subtle, but as the disease progresses, symptoms become more severe. Treatment options include abstinence, nutritional therapy, medication, and in severe cases, liver transplant. For expert care and treatment, consult the specialists at Arvachin Hospital. They offer comprehensive services to help manage and treat alcoholic liver disease effectively.
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Phone: +91–9695953111, 05422978222
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Visit: Amara Khaira Chak, Akhari bypass NH2, Varanasi
Arvachin Hospital is dedicated to providing exceptional healthcare services to ensure your well-being.
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India’s best liver transplant surgeons have extensive experience and an impressive track record in conducting transplant surgeries, having completed over 750 liver transplants with high survival rates.
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Combined Liver-Kidney Transplantation: When and How?
Combined liver-kidney transplantation (CLKT) is a procedure where both a liver and a kidney are transplanted simultaneously into a recipient who requires both organs due to end-stage organ failure. Here are some key points about when and how CLKT is performed:
When is CLKT considered?
Indications: CLKT is typically considered when a patient has concurrent liver and kidney failure. This could be due to:
Chronic kidney disease (CKD) progressing to end-stage renal disease (ESRD) alongside liver failure, often seen in conditions like cirrhosis.
Acute kidney injury (AKI) that does not recover, combined with acute liver failure.
Evaluation: Patients undergo rigorous evaluation to determine the need for CLKT. Criteria include severity of liver disease (often assessed by MELD score) and kidney disease (usually assessed by eGFR or need for dialysis).
How is CLKT Performed?
Surgical Procedure: CLKT involves transplanting both organs simultaneously in a single surgical procedure. The liver is typically transplanted first, followed by the kidney. The surgical team may consist of liver transplant surgeons and renal transplant surgeons working together.
Immunosuppression: After transplantation, patients require lifelong immunosuppressive therapy to prevent organ rejection. The immunosuppressive regimen is tailored to balance preventing rejection with minimizing side effects.
Recovery: Recovery from CLKT involves monitoring for organ function, managing immunosuppressive medications, and addressing any post-operative complications. Recovery times can vary, but patients typically stay in the hospital for several weeks post-surgery.
Considerations and Outcomes
Patient Selection: Selecting appropriate candidates for CLKT is crucial. Candidates should have a reasonable expectation of survival and improvement in quality of life compared to their pre-transplant state.
Outcomes: CLKT can offer excellent survival rates and improved quality of life for appropriately selected patients compared to sequential liver and kidney transplants or other treatments.
Challenges: CLKT is a complex procedure with inherent risks, including surgical complications, rejection of transplanted organs, and side effects from immunosuppressive medications.
In summary, CLKT is performed when a patient has concurrent liver and kidney failure and is evaluated as a suitable candidate for dual organ transplantation. The procedure involves simultaneous transplantation of both organs, followed by lifelong management with immunosuppressive therapy to maintain organ function and prevent rejection.
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