#karl fischer titrator

[kimberlabnics]

Karl Fischer Titrator

Labmate Karl Fischer Titrator offers solvent inhalation, determination, and wastewater discharge functions. Easy operation via panel keys. Electrode polarization voltage signals titration end with an alarm. Measuring range: 0.02% to 100%, moisture resolution: 0.01ml.

[analabtron]

Ambient Temperature=10-deg-c-to-35-deg-c; Measurement Range=0-to-100-mg; Resolution=0-1-micro-g; Max. Electrolysis Speed=40-micro-g-s; Amount and Precision of electrolysed water=10-micro-g-to-1000-micro-g-plusmn-2-micro-g-and-gt-1000-micro-g-0-2. Shop Online at Labtron.us

[pharmablogs]

Karl Fischer Titration

Principle of Karl Fischer Titration: The principle of Karl Fischer titration is based on the oxidation reaction between iodine and sulphur dioxide.

Principle of Karl Fischer Titration The principle of Karl Fischer titration is based on the oxidation reaction between iodine and sulphur dioxide. Water reacts with iodine and sulphur dioxide to form sulphur trioxide and hydrogen iodide. An endpoint is reached when all the water is consumed. The chemical equation for the reaction between sulphur dioxide, iodine, and water (which is employed…

[compleattsinc]

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Validate HPLC, GC, and ICP-MS systems for accurate analytical results

Validate Karl Fischer Titrators for precise moisture content determination

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[qwdqada]

Principle of Karl Fischer

The idea of Karl Fischer’s titration is solely based on the oxidation reaction between sulphur dioxide and iodine. Iodine and sulphur dioxide react with water to form hydrogen iodide and sulphur trioxide, respectively. When all the water is drank, it reaches a conclusion. The chemical equation that takes place for the reaction between sulphur dioxide, iodine, and water (which is applied during the Karl Fischer titration) is provided below.

I₂ + SO₂ + H₂O → 2HI + SO₃

Applications of Karl Fischer

It can be used in technical products such as plastics, oils, gases

It is used in cosmetic products

It is used in pharmaceutical products

It is used in the industry

[labtroncc]

Coulometric Karl Fischer Titrator

Labtron Coulometric Karl Fischer Titrator features precise moisture analysis with a sensitivity down to microgram levels, an integrated reagent exchange system, and a user-friendly interface with digital display. Specifications include titration cell volume, measurement range (ppm to percent), accuracy, compliance with ASTM and ISO standards, and compatibility with various sample types.

[labnics25]

Karl Fischer Titrator

Karl Fischer Titrator - NKFT-100 is a volumetric type auto analyzing titrator that helps to determine the moisture content of a sample. It is an enclosed automated system with a reagent bottle adaptor and an endpoint detector that sets it free from environmental interference. The functions like solvent inhalation, determination, wastewater discharge, can easily be operated by its panel keys. The electrode polarization voltage aids in determining the end of the titration process with an alarm sound.

[chemstockforchemicals]

Hanna Instruments HI-933 Karl Fischer Titrator - CHemstock

🔬 Unveiling the HI-933 Karl Fischer Titrator: The All-in-One Moisture Mastermind 🔬

Are you tired of inaccurate or time-consuming moisture analysis? Look no further! Chemstock the best Laboratory equipment supplier proudly presents the HI-933 Karl Fischer Titrator from Hanna Instruments, designed to revolutionize your testing process. This powerful titrator delivers unmatched accuracy and efficiency, making it the perfect choice for a wide range of applications.

💡 Here's what sets the HI-933 apart:

🌟 Unmatched Performance:

Precise moisture determination from 100 ppm to 100%.

Dynamic titrant dosing for faster, more accurate results.

Automatic drift rate compensation for reliable analysis.

🎨 User-Friendly Design:

Compact footprint saves valuable bench space.

Intuitive interface with a large color LCD display.

Customizable reports and data storage for seamless workflow.

🚀 Advanced Features:

Sealed solvent system minimizes water vapor entry.

Precision dosing pump ensures accurate titrant delivery.

Visually recognizable desiccant simplifies maintenance.

🌐 Broad Capabilities:

Stores up to 100 user-defined or standard titration methods.

Supports integration with laboratory balances and other peripherals.

Customizable endpoint criteria for optimal flexibility.

💼 Unparalleled Support:

Hanna offers comprehensive on-site installation and training.

Benefit from ongoing support via phone or webinars.

Access to pre-programmed standard methods for various industries.

🔍 The HI-933 is the perfect solution for:

Chemical analysis

Food and beverage production

Pharmaceutical manufacturing

Environmental monitoring

And much more!

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[labmate-inc]

Karl Fisher Titrator

Karl Fisher Titrator is a cutting-edge instrument designed for precise water content determination in solutions, even down to 1% using volumetric analysis. This device prioritizes safety during chemical handling through automated reagent filling, removal, and mixing. Its volumetric measurement range spans from 0.1 mg to 250 mg, boasting exceptional accuracy from 0.1 mg to 20 mg. With ample data storage, it accommodates up to 200 volumetric and 200 Coulometric records, all compliant with GLP standards for easy retrieval. This versatile instrument offers both titter detection and KF titration modes suitable for a wide array of solvents.

Karl Fischer titration is a widely used and accurate method for water content determination, especially when dealing with trace amounts of water. It is particularly important in industries where moisture control is critical, such as the pharmaceutical, chemical, and food industries. The Karl Fischer reagent, known for its quantitative and selective reaction with water, enables precise moisture content measurement. In summary, the Karl Fisher Titrator is a sophisticated tool that ensures meticulous water content analysis with safety, accuracy, and convenience.

https://www.labmate.com/karl-fisher-titrator

 #titrator, #karlfisher, #karlfishertitrator

[spectralabinstruments]

After 25 years of dedication to quality and knowledge, Spectralab begins a new decade. Since its founding in 1981, when its first product was released, Spectralab has played a crucial role in determining the requirements of analytical chemists and providing them with solutions.

Contact Spectralab to Buy Automatic Potentiometric Titrator in India

We offer a variety of tools, including nephelometers, turbidity meters, and Karl Fischer titrators. Address: W-446, Rabale MIDC, Rabale, Navi Mumbai – 400701, Maharashtra, India.

Telephone No. 91 22 62556868 (100Lines)

Email: Marketing@spectralab.biz

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[flexitest1234]

Determination of moisture analysis in pharmaceutical products/industries.

Moisture analysis is a critical process in the pharmaceutical industry to determine and control the moisture content in pharmaceutical products and raw materials. Excessive moisture can affect the stability, quality, and efficacy of pharmaceutical products, leading to potential degradation, microbial growth, and reduced shelf life. Therefore, accurate moisture analysis is crucial to ensure product safety and compliance with regulatory standards.  Loss on drying (LOD) is the most common method used for moisture analysis. It involves weighing a sample before and after drying it at a specific temperature until a constant weight is achieved. The weight difference represents the moisture content. Karl fischer titration is widely employed for the accurate determination of water content in pharmaceuticals. It uses a specialized titration technique based on the reaction between iodine and water. Karl Fischer titration is highly sensitive and can detect low levels of moisture. NIR spectroscopy is a non-destructive technique that measures the absorption of near-infrared light by pharmaceutical samples. Different molecular vibrations, including water, absorb specific wavelengths of light, allowing for the determination of moisture content. This variant of Karl Fischer titration utilizes an electrochemical cell to quantify the moisture content in pharmaceutical samples. It offers high accuracy and sensitivity and is suitable for both low and high moisture levels. Thermogravimetric (TGA) method measures the weight changes of a sample as it is heated. By analyzing the weight loss during heating, the moisture content can be determined.  These specialized chambers create controlled environmental conditions of temperature and humidity to simulate the storage and transportation conditions of pharmaceutical products. The weight change of the sample over time provides information on moisture content. It is important to follow appropriate sampling techniques and validate the chosen method to ensure reliable and accurate moisture analysis. Additionally, regulatory bodies such as the United States Pharmacopeia (USP) provide guidelines and standards for moisture analysis in the pharmaceutical industry to ensure product quality and safety.

Quality control of moisture content in pharmaceuticals is crucial to ensure product safety, stability, and efficacy. By implementing robust quality control measures for moisture content, pharmaceutical manufacturers can maintain the integrity and quality of their products, mitigate risks associated with excessive or inadequate moisture, and meet regulatory requirements. There are the key aspects of moisture content control in the pharmaceutical industry that is defining appropriate moisture content specifications for each pharmaceutical product based on its formulation, stability, and intended use. These specifications should be established considering regulatory requirements and industry standards. Selecting suitable moisture analysis methods, such as Loss on Drying (LOD), Karl Fischer titration, NIR spectroscopy, or other validated techniques, based on the product characteristics and regulatory guidelines. The method chosen should be accurate, reliable, and capable of detecting moisture within the desired range.  Follow proper sampling techniques to ensure representative samples are collected. Consider factors such as sample size, storage conditions, and sample handling to prevent moisture contamination during collection. Properly prepare samples to ensure uniformity and accuracy during analysis. Homogenize or mix the sample thoroughly to eliminate moisture concentration variations within the sample. Calibrating and validate moisture analysis instruments regularly to maintain accuracy. This includes verifying the accuracy and precision of the method using reference standards or certified materials. Validate the selected moisture analysis method to ensure it is suitable for the intended purpose. Method validation should involve assessing parameters such as accuracy, precision, linearity, specificity, and robustness. Conduct regular moisture content testing during different stages of pharmaceutical manufacturing, including raw materials, in-process samples, and finished products. Set appropriate sampling frequencies and ensure compliance with established procedures. Record and analyze moisture content data for each batch or lot. Maintain accurate and comprehensive documentation of all test results, including the sample details, testing conditions, and instrument calibration records.  If moisture content test results fall outside the specified limits, perform thorough investigations to identify the root cause. Implement appropriate corrective and preventive actions (CAPA) to address any issues identified during the investigation. Ensuring compliance with relevant regulatory guidelines, such as those outlined in pharmacopeias (e.g., USP, EP, JP), Good Manufacturing Practices (GMP), and other applicable regulations. Stay updated on any changes to regulations and adjust quality control practices accordingly. The moisture content in pharmaceuticals can have a significant impact on product quality, stability, and efficacy. To mitigate the impact of water content in pharmaceuticals, manufacturers must establish appropriate moisture specifications, implement robust quality control measures, conduct stability studies, and employ suitable packaging materials and storage conditions.

Additionally, adherence to Good Manufacturing Practices (GMP) and regulatory guidelines is essential to ensure product safety, efficacy, and compliance with industry standards. Water can react with pharmaceutical ingredients, leading to chemical degradation. This can result in reduced potency, formation of impurities, or loss of the desired therapeutic activity. Moisture-sensitive compounds may undergo hydrolysis, oxidation, or other degradation reactions in the presence of excessive water, excessive moisture content can lead to the growth of bacteria, fungi, or other microorganisms, which can contaminate pharmaceutical products. Microbial contamination can compromise product safety and efficacy and pose health risks to consumers. The moisture content in pharmaceuticals is a crucial factor in determining product shelf life and storage conditions. Excess moisture can accelerate degradation reactions and reduce the stability of active ingredients, resulting in shorter shelf life. It is essential to control moisture levels to maintain product quality and ensure appropriate storage conditions (e.g., temperature and humidity) to prevent moisture-related degradation. Moisture-sensitive pharmaceuticals require appropriate packaging materials to protect them from moisture ingress. Excessive moisture can compromise the integrity of packaging, leading to moisture transfer into the product or moisture loss from the product. This can impact stability, efficacy, and shelf life. Moisture content can influence the accuracy and reliability of analytical testing methods used for potency determination, impurity analysis, or dissolution testing. It is crucial to control and account for the moisture content during analytical testing to ensure accurate and consistent results.

It's important to note that each method has its advantages, limitations, and appropriate applications. It is advisable to validate the selected method according to regulatory guidelines and to follow appropriate sampling and sample preparation techniques to ensure accurate and reliable moisture content measurement in pharmaceuticals, to measure moisture content in pharmaceuticals, various methods can be employed. The selection of a specific method depends on factors such as the nature of the pharmaceutical product, the required accuracy, the moisture range of interest, and the regulatory requirements

[finarchemical]

Finar’s Best Laboratory Chemical: Karl Fischer Reagent

Laboratory chemicals are known to be substances employed in scientific research, analysis, and experimentation. They can include a wide range of substances such as acids, bases, solvents, reagents, and other chemicals that are used to conduct experiments and analyze samples in a laboratory setting.

These chemicals are typically highly purified and have known properties and characteristics, making them useful for a variety of scientific applications. They may be used in fields such as chemistry, biology, physics, and engineering to conduct experiments, make measurements, or analyze samples. 

It is important to handle laboratory chemicals with care and follow proper safety procedures to ensure the safety of both the researcher as well as the environment. Proper storage, handling, and disposal of these chemicals are also critical to prevent accidents and minimize environmental impact. Therefore, the lab chemical suppliers take ample care before using these chemicals. 

A very common and widely used laboratory chemical happens to be the Karl Fischer reagent. Let’s take a closer look at it

Karl Fischer reagent is a commonly used laboratory reagent used for the determination of water content in a wide range of samples. A German chemist named Karl Fischer developed this method of water analysis. Hence, the reagent is called Karl Fischer. 

Karl Fischer reagent consists of an iodine solution, sulfur dioxide, pyridine, and a solvent such as methanol or ethanol. The reagent is added to the sample, and the water in the sample reacts with iodine to produce iodide ions. The iodide ions are then titrated with a standardized solution of iodine to determine the water content in the sample.

The Karl Fischer method is highly specific and accurate for the determination of water content in samples, even at very low levels. It is generally used in a variety of laboratory applications, including in the pharmaceutical, food, and chemical industries. 

Some specific uses of Karl Fischer reagents in laboratories include:

Analysis of water content in pharmaceuticals, including tablets, capsules, and syrups.

Testing water content in food and beverage products such as juices, dairy products, and canned goods.

Analysis of water content in chemicals such as solvents, surfactants, and polymers.

What is the general method of preparing Karl Fischer's reagent? 

Start with high-purity iodine crystals and sulfur dioxide gas. The iodine should be sublimed and distilled to remove any impurities.

Place the iodine crystals in a round-bottom flask with a magnetic stir bar.

Slowly add the sulfur dioxide gas to the flask with vigorous stirring. The reaction between iodine and sulfur dioxide will produce iodine monochloride, which is a key intermediate in the formation of the final reagent.

Continue stirring the mixture until all of the iodine has dissolved and the solution becomes clear. The solution will have a yellow colour due to the presence of iodine monochloride.

Once the iodine has dissolved, add the base component, typically pyridine or imidazole. The base is added to the solution to scavenge the hydrogen ions produced during the reaction between iodine and water, allowing the reaction to continue until all the water is consumed.

The final solution is a Karl Fischer reagent that can be used for water determination in a variety of samples.

It is important to note that the preparation of Karl Fischer reagent requires proper safety precautions, including the use of a fume hood and appropriate personal protective equipment. Additionally, the specific recipe and conditions for preparing Karl Fischer reagents may vary depending on the intended use and the supplier of the reagents.

If you’re searching for the best laboratory chemicals manufacturers in India, Finar Chemicals is where you need to be! It is a leading manufacturer of laboratory chemicals, offering a wide range of high-purity solvents, reagents, and biochemicals. With a robust focus on quality, innovation, and sustainability, Finar Chemicals has become a trusted name in the chemical industry.

[foodtech101blog]

How to determine Moisture content in food ?

How to determine Moisture content in food ?

Determination of moisture is one of the most important experiment in Food Science & Technology, also in food industry. In this blog, you will learn about the importance, methods & various facts about the analysis of moisture in any food sample. Why moisture content is estimated?  To determine Microbial stability of food by knowing moisture % & water activity (aw)In order to maintained food…