#euthanatize

[understandingnembutal]

Understanding Nembutal: It Uses, Side Effects and Risks

Nembutal, also referred to as pentobarbital, is a potent sedative drug that is a member of the barbiturate drug family. The primary uses of this drug today are for anesthesia and euthanasia, though it was once used as a sedative-hypnotic medication.

Nembutal is a tightly regulated drug that can only be obtained with a prescription from a qualified vendor. Seizures, anxiety, and insomnia are a few of the conditions that it is typically used to treat. Nembutal causes sedation, relaxation, and reduced anxiety by depressing the central nervous system.

Nembutal is frequently misused for its euphoric effects despite its therapeutic benefits. The drug is listed as a Schedule II controlled substance under the United States Controlled Substances Act because of its high potential for addiction and overdose.

The most typical uses of nembutal are for physician-assisted suicide or euthanasia. In some nations, it is acceptable for terminally ill patients to request Nembutal as a suicide drug. However, this is an extremely contentious practice that is illegal in many nations.

Concerns about Nembutal's availability and use in illegal and hazardous ways have also arisen as a result of its use in euthanasia. The use of nembutal illegally has been linked to an increased risk of overdose, death, addiction, and other negative effects.

In conclusion, the strong sedative drug nembutal has both therapeutic and potentially harmful applications. It must only be used under the direction and supervision of a qualified medical professional, and it must never be used for illegal activities. Seek immediate professional assistance if you or someone you know is struggling with substance abuse or addiction.

Pentobarbital Group is a seasoned and competent online publication that focuses on writing informative articles on nembutal and where to buy nembutal lawfully. Pentobarbital Group has a thorough awareness of the uses, advantages, and hazards related to this product and offers insightful information to readers looking for accurate and trustworthy information. Their articles are based on thorough research, and they are written in a way that makes difficult concepts simple to comprehend. Pentobarbital Group is contributing to the greater discussion regarding the use of nembutal in modern medicine by sharing their knowledge and encouraging safer and more knowledgeable usage of the drug.

[arttsuka]

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[bonesandpoemsandflowers]

read an article today about how the massive amounts of DDT off the coast of California combined with herpes is "goo-ifying" the genitals of male seal lions and giving them "gnarly" cancer and the amount of suffering we've inflicted on the world is truly haunting and i, the individual, can do nothing about many specific situations.

[leekimdramas]

Yonder Review (Spoiler Free)

If you were dying... Would you like to go to a virtual place where your memories, You, can live forever?

Kim Jae Hyun’s wife is dying... He has a few more minutes left to share the last moments before she will be euthanatized. 

However, a strange women comes into the house and puts something that will keep the wife’s memories and she will never die.

This is a very interesting concept and it’s very though provoking. It will definitely make you think if what the main characters are doing is even reasonable.

But the drama is not really here to say this is bad or good. There are different perspectives and you can decide yourself.

If living forever is such a bad thing...

This is also a very short drama, so it’s easy to binge. Personally, I had a bit of a trouble coming back to the drama because it touches on the hard/sad moments of life and I wasn’t feeling like I can just watch them continuously. 

So making breaks in between was the way to watch it.

The actors were amazing, we’re talking about Shin Ha Kyun and Han Ji Min after all. I felt what they felt and they were really good together.

Overall, this was a very interesting, in a good way, watch. I wanted a little bit more from the ending but at the same time it’s not really my place to judge the characters.

They thought they picked the right answer and that’s what matters. Plus with that answer we got to dive deeper into the supposedly heaven.

10/10

[petculiars]

What Do Pet Snakes Eat?

New Post has been published on https://www.petculiars.com/what-do-pet-snakes-eat/

What Do Pet Snakes Eat?

It is known that snakes can eat strange things from golf balls, and bulbs, to sheep, and alligators, and with such a reputation, it makes sense to ask: What do snakes eat?

Different types of snakes eat different things

There is no single diet to describe what snakes eat. Since there are many types of snakes, they will feed differently. Some snakes have special bodies that allow them to eat only one type of prey. For example, snakes that eat eggs only eat eggs.

Fortunately, usually, pet snakes will be limited to a basic diet consisting of mice and rats. Snakes are carnivores, and a rat or mouse is usually a complete and balanced meal for them.

Certain species of snake can also eat chicken, guinea pigs, gerbils, or young rabbits. Some snakes also eat insects, frogs and amphibians, earthworms, eggs, other reptiles, bats, and even birds.

Each species of snake has a different diet. However, snakes always feed on animal matter, never on plant material. Their teeth are not designed for plant consumption.

Should the pet snake’s food be alive?

You might also like my articles about whether:

Do anacondas eat people

Constrictors as pets

How to know if your snake is sleeping

Although snakes prefer live food, it is recommended to feed your pet snake only dead prey. There were incidents where the live prey was left inside the snake terrarium and it did not consume it immediately. In defense, the prey bites or attacks the snake, and can seriously hurt it.

Factors on which the feeding of a pet snake depends

Because a snake’s diet can vary so much, it’s important to do some research before buying a snake pet. In captivity, it is always best to feed your snake dead prey, or frozen prey, but defrost it before giving it.

However, some snakes will not eat previously dead food. So, make sure your snake has already followed such a diet, with frozen and then defrosted animals, before bringing it home. However, there are some exceptions to this rule. Young snakes that eat young mice will not eat prey unless it moves. So, for them, living prey is acceptable.

There are several reasons to make sure your snake is in the right place, and it will consume dead or defrosted meat. And one of these reasons is the cruelty factor. If you feed your snake with living prey, that prey often suffers more than is necessary to become the food for the snake. If the prey can be euthanatized before, it is generally better.

In addition, the living prey can fight back. If it is a rodent, it can bite the snake as it tries to eat it. The snake will generally win the fight but may be injured in the process.

Another reason to buy frozen food is to avoid any kind of parasite that the prey can carry. Live prey can have internal parasites like worms, or external parasites like ticks, and fleas. Any of these can also harm the snake.

An additional advantage when offering frozen foods is that they are cheaper and you can make a stock. You don’t have to buy live animals when you have to feed the snake.

How much food do snakes eat?

The amount of food a snake will eat during each feeding will depend on its age, size, and species. Whenever you feed your snake, make sure that the prey is not more than half the diameter of the snake. This will help with digestion.

As a general rule, you can give the snake the entire prey. No need to cut it into smaller pieces. This is because the jaw of a snake is not joined inside the face, as in humans. It is connected by a ligament, which makes the jaw very flexible and allows it to rotate vertically and horizontally. This is why snakes are able to eat an entire large prey.

Do snakes drink water?

Snakes drink water, but not very often. However, the snake should always have a large bowl that is a little deep with water at its disposal. The snake can soften itself in it and even make its needs in this water. Water evaporation also helps maintain proper humidity inside the terrarium.

How often do snakes eat?

Snakes do not eat often. Usually, they will consume one meal only once a week or once every two weeks, maybe even more. Smaller, younger snakes can eat 2 times a week, and larger, older snakes may not eat for weeks.

Not sure if the snake is hungry? There are some signs you can look for. For example, the snake may become more active or start climbing on the sides of its enclosure as if it were looking for food. Be careful with the intestinal transit as it may become hungry afterward.

Important advice when feeding pet snakes

Now that you know what snakes eat, you should know that it is advisable to move the snake to another feeding facility, separate from where it usually sits. This can decrease the aggression of the snake and make it less likely to attack if it is hungry.

In addition, you should wait 48 hours after feeding before handling the snake. Snakes can be stressed, just like humans, and if their prey is not fully digested, it can be regurgitated.

Wash your hands thoroughly before and after feeding the snake. Many reptiles can carry Salmonella, a life-threatening bacterium that can spread from pets to humans. And vice versa, any chemicals on your hands, for example, moisturizers, lotions, hand disinfectants, etc., can be transferred to the skin of the snake, which can cause irritation.

Final words! So, what does your pet snake eat?

You will need to do research for the specific species of snake you are buying to find out what it will eat. If it is a more general species, it is best to provide it with several types of food, such as live crickets, fish, frogs, and small mammals such as mice and rats.

But if the snake species is more specialized and eats only one type of food in the wild, be prepared to always have that food at hand.

Keep in mind that most snakes eat every 5-14 days. So, determine in advance the types of food you will need to buy for your new pet, to ensure that it remains happy, healthy, and well-fed for years to come.

[tired-fandom-ndn]

That person is unironically talking about mass euthanatizing people. As a Jew I noped the fuck out of that one. HOW are they not horrified by this language??

(Regarding owlvi/d)

Wish I could say this was the first time a popular and well-loved tumblr user has explicitly said that people with certain mental illnesses should be euthanized or sterilized and still gotten waves of love and support, but I can't.

[pokedext]

Today reminded me the hardest part of my job is letting client decide when it’s time to let go of a pet. I understand the inability to decide sometimes comes from love, but I’ve seen animals pain prolonged just because a client isn’t ready to let go. Today a women with her cat that has cancer on her neck/mouth was told point blank by the vet if it were his cat he’d have her euthanized and give her some dignity instead of the possibility of dying painfully at home. So we scheduled her for Tuesday euthanasia, but by the end of the appointment she wanted medication that lasted longer than the 3 days in case she decides not to euthanatize on Tuesday. She’s trying to bargain with God and time, there is no saving grace here. 

[newtyp]

Can someone find me that comic on euthanatizing a pet?

It has a dog being put down. 

[missrumaania]

#Repost @tanyasrocksforjustice • • • • • Some people think that this is a manly sport. Think again you small dicked assholes! Hurting calves that can’t fight back ain’t fair game! How about you try this on a grown bull...without any weapons, just you and him one on one...yeah, didn’t think so!!!!!! Make the dam connection people! Shame on you if you support this awful disgusting sport!!!!!!!!! RP @donnamaria1961 THE CALGARY STAMPEDE @sherylcrow along with other paid performers attended this years @calgarystampede __________________________________ “If it makes you happy, it can’t be that bad” Wanna bet #cherylcrow ???? ____________________________________ Canada’s Calgary Stampede is a SPECTACLE OF ANIMAL ABUSE. The list of animals injured and killed is never going to stop when entertainers endorse and audiences pay to watch this horror show. Another year has come and gone. More animals lost their lives in this blood sport that takes place every year. Another horse broke its leg in the extremely dangerous CHUCKWAGON RACE in the most recent stampede. The animals injured are not “euthanatized”. They’re shot dead. Euthanasia is just a nice way of saying killed because they’re disposable commodities. Their lives are meaningless and another bullet awaits the next innocent victim who is injured. These animals did not sign up willingly. They’ whipped excessively and forced into an extremely dangerous situation. As for “CALF ROPING” !!! How anyone in their right mind can find this entertaining is lacking something in their brain. The list of animals injured and killed that are “USED” to perfect “cowboy rodeo skills” is unaccounted for and unacceptable. Entertainment should never have a victim and I’m done with celebrities supporting animal cruelty and abuse. Seaworld lost a ton of celebrity endorsers after Blackfish. The Calgary Stampede is horrific and what we see is only a small portion of the cruelty. Thank you to everyone who signed the petition. Shame on @calgarystampede and Warren Connell the CEO of the Calgary Stampede for supporting animal cruelty as bad as bullfighting.

[pittylover728]

I’m going to let my favorite 2 most handsome Florida boys I’ve ever seen drop some #pitbull knowledge on you real fast. #ignoranceisnotblissitsignorance Posted @withregram • @noah_and_lincoln Who you calling dangerous? 😠👊🏼 .. .. These heroes are celebrating National Pit Bull Awareness Month! Even though Noah and Lincoln are labeled as American Bully on paper, many people still refer to them as “pitbulls”. The word pitbull does not define a “pitbull” breed. But many dogs that share the same physical characteristics such as American Pit Bull Terrier, American Bulldog, Cane Corso, Bull Terrier, Staffordshire Bull Terrier, etc., are labeled as pitbulls because that term has been deemed as a catch all for these breeds and more. .. .. There are several types of AmBully; Pocket, Standard, Classic, Extreme, and XL. In the last few years they’ve added what’s called an exotic American Bully, which has different color patterns that include spots. Each one is obviously derived from different breeding practices and each category has similar and unique features. Their lifespan can be between 10-12 years. These dogs are prone to being overweight if not exercised regularly and may suffer from joint issues later in life. Their overall temperament is gentle, loving towards people and other dogs, and loyal. These dogs thrive under regular training routine, a strong pack leader and clear set boundaries. .. .. So, you see why there is so much confusion with calling a dog that appears to look like a “pitbull” a pitbull. The AmBully has several categories within the breed. Hence, causing mislabeling which has caused for many dogs to be euthanatized, deemed dangerous and even banned. .. .. I hope this has given you a little more of a background for the American Bully. I know breed doesn’t matter to us as we see them as big loving hippos but for the public it’s important to understand that each bully breed is different and not one is a single pitbull because there isn’t a pitbull breed. . . . . . #thedodo #ilovemydogs #dogoftheday #americanbully #funnydogs #bullybreed #bullygang #dogmom #bullymom #americanbullyxl https://www.instagram.com/p/CGNIKJgAn6U/?igshid=wkeq3ycpy180

[biomedgrid]

Biomed Grid | Echinchrome Pigment Isolated from Sea Urchin Improves Female Rat’s Fertility

       Introduction        

Infertility is considering disease which characterized by the failure to establish a clinical pregnancy after one year of regular and unprotected sexual intercourse during the fertile phase of the menstrual cycles [1]. Infertility is a stressful and unexpected experience by a couple and is estimated to affect 8%–12% of couples worldwide [2]. About 15–30% of the infertile couples are diagnosed with unexplained infertility after basic fertility tests after they cannot achieve a pregnancy due to accident or to undetected causes, including oviduct dysfunction with tubal patency, fertilization failure and implantation failure without an organic lesion [3]. Oxidative stress may contribute to aging and several diseased states affecting female reproduction [4]. Recent reports identified an excessive amount of reactive oxygen species (ROS) caused by alcohol consumption, cigarette smoking, varicocele, and obesity, among other factors, results in infertility [5]. Approximately 190 million patients are infertile worldwide including recurrent implantation failure and recurrent pregnancy loss [6]. Treatment of infertility may use drugs or surgical procedures.

Unfortunately, these treatments are expensive and associated with side effects [7]. Therefore; alternative medicines have proven efficacious in the treatment of infertility. Marine organisms are a wonderful source of biologically active natural products [8]. There is much valuable information for new antibiotic discoveries from sea urchin (Phylum Echinodermata, class Echinoidea), which give new insights into bioactive compounds within it [9]. Sea urchin has a number of unique substances, such as quinonoid pigments named spinochromes [10]. From these compounds, Echinochrome (Ech) which is the most common dark red pigment of sea urchin shells, spines, and eggs [11]. It has ability to improve mitochondrial function in the heart and therapeutic potential against cardio-toxic agent [12,13]. In addition, Ech consider strong hypolipidemic agent which also possess ability to improve renal function [14,15]. Thus, the present study aimed to evaluate effect of Ech on fertility of female rats.

       Methods Sea urchin collection

Sea urchins (Paracentrotus lividu) were collected from the Mediterranean coast of Alexandria (Egypt). They washed with sea water at the collection site to remove sand and overgrowing organisms and transport to the laboratory packed in ice.

Echinochrome (Ech) extraction

The internal organs of sea urchins were removed, and then the shells and spines washed with a stream of cold water, air-dried at 4 °C for 2 days in the dark and then grounded. The powders (50 g) were dissolving by gradually adding 100 ml of 6 M HCl. Three times extraction of the pigments with the same volume of diethyl ether. The ether layer collected washed with 5% NaCl until the acid almost removed. The ether solution including the pigments dryad over anhydrous sodium sulfate and the solvent evaporated under reduced pressure. The pigment stored at -30 °C in the dark [16,17].

Experimental animals

From the National Research Center (NRC, Dokki, Giza) twenty seven Wistar rats (18 virgin female rats, 7–8 weeks old, 200–220 g; and 9 mature male rats, 14–15 weeks old, 240–260 g) were obtained, transferred to our breeding colony and maintained on a 12hr light/dark cycle and controlled temperature (23 ± 2 °C). The animals had given food and water ad libitum.

Reproductive management

After one week of acclimatization the females were started the oral administration of DMSO, low and high dose of Ech for 30 days. At the end of the month the female’s mate with males (2: 1). The presence of sperm in the vaginal lavage will consider day 0 of gestation. If no sperm were observed in the vaginal smears in any of the females within 7 days of mating, the male was replaced by another male.

Ethical consideration and Field study

Experimental protocols and procedures used in this study were approved by the Cairo University, Faculty of Science, Institutional Animal Care and Use Committee (IACUC) (Egypt) (CUIF718). All the experimental procedures were carried out in accordance with international guidelines for the care and use of laboratory animals.

Experimental design

a) 18 virgin females will assign into 3 groups (6 rats/ group):

b) Control: Rats received 1 ml 2% DMSO (orally) daily for 30 days

c) Low dose Ech: Rats received 1 ml of 0.1 mg/kg Ech (in 2% DMSO, orally) daily for 30 days

d) High dose Ech: Rats received 1 ml of 1 mg/kg Ech (in 2% DMSO, orally) [14] daily for 30 days.

After thirty days the treated females’ rats cohabited with normal males, then the females allowed to complete the pregnant period. At day 20, the animals had euthanatized, and blood sample were collected for biochemical analysis. The fetuses were removed from uterus and were blotted on blotting paper. Embryo number, length and weight were recorded.

Biochemical analyses

The serum glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin, total protein, albumin, creatinine, urea, uric acid, total cholesterol (TC), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C), triglycerides (TG), follicular stimulated hormone (FSH), luteinizing hormone (LH), testosterone were determined according to the manufacturer’s instructions using Spectrum Diagnostics and Bio-diagnostic kits (Giza, Egypt).

Statistical analysis

Values were expressed as means ± SE. The comparisons within groups were evaluated utilizing one way analysis of variance (ANOVA) with Duncan post hoc test was used to compare the group means and p<0.05 was considered statistically significant. SPSS, for Windows (version 15.0) was used for the statistical analysis.

       Results        

High dose of Ech caused significant (p<0.05) decrease in levels of glucose, AST, ALT, ALP, Creatinine, Urea, Uric acid, TC, LDL-C, Tg, while TP, Albumin and HDL-C increase (Table 1). Table 2 showed significant increase in FSH, LH, Uterus weight, Body weight gain, Placenta weight, Embryos number, Embryos weight, Embryo length, while Testosterone decreased after the treatment with high dose Ech.

Table 1: Effect of different doses of Echinochrome (0.1 and 1 mg/kg) on biomarkers of female rats.

Note: Values are means ± se (n = 6 per group). Each value not sharing a common letter superscript is significantly different (P <0.05).

Table 2: Effect of different doses of Echinochrome (0.1 and 1 mg/kg) on Maternal and Fetal outcome of female rats.

Note: Values are means ± se (n = 6 per group). Each value not sharing a common letter superscript is significantly different (P <0.05).

               Discussion        

Infertility is an important public health problem and diagnosis and treatment are stressful, invasive, and costly [10]. Obesity and lifestyle factors such as cigarette smoking, alcohol use, and recreational drug use can promote excess free radical production, which could affect fertility [4]. Ech known as powerful antioxidant natural product which may improve fertility by prevent oxidative stress state. Oxidative stress is one of the most frequent problems in patients with obesity [19]. In the present study Ech showed hypolipidimic activity by decrease levels of TC, Tg, LDL-C and increase HDL-C. This improve in lipid profile state was confirmed by many previous studies [15] [14] and consider main factor for enhancing fertility. Female obesity and known to adversely affect fertility through changes of hormone patterns and the menstrual cycle [18]. Therefore, alterations in liver function due to alcohol consumption may result in altered metabolism of the exogenous gonadotropins used in In vitro fertilization, as well as the estrogen response of ovarian follicles to stimulation. In theory, these hormonal shifts could result in abnormal folliculo genesis and impaired endometrial receptivity [20].

Liver play essential role in the fertility where liver function affects the reproductiion by modulating sex steroid metabolism and transport to tissues [21] Our study revealed that high dose of Ech improve liver function by decrease AST, ALT, ALP activities and increase protein production which consider other pathway for improve fertility. Maintained of kidney functions play important role in fertility.Renal insufficiency is usually accompanied by impaired reproductive function, particularly among females [22]. The current study proved the ability of Ech to improve kidney functions which enhance fertility in female rats. Hyperglycemia and elevated lipids acutely suppress LH and FSH [23]. So, the hypoglycemia and hypolipidemic activities of Ech have amelioration effect on LH and FSH in the present study. In the present study uterus weight, body weight gain, placenta weight, embryos number, embryos weight, embryo length increased after the treatment with high dose Ech. An improvement in sex hormones, lipid profile, glucose level, liver function and kidney functions is the suggested pathways for amelioration the fertility in female rats.

  Conclusion        

Echinchrome ameliorate female rats’ fertility through an improvement in sex hormones, lipid profile, glucose level, liver function and kidney functions.

Read More About this Article: https://biomedgrid.com/fulltext/volume3/echinchrome-pigment-isolated-from-sea-urchin-improves-female-rats-fertility.000651.php

For more about: Journals on Biomedical Science :Biomed Grid

[weepingmusicartisan]

Are you in Chicago? Pumpkin is celebrating with a "kitten party"/adoption event on October 19!

[thatjokegavemecancer]

We’re overdue now I think..

The most wonderful and beautiful day of my life has come and gone. Our wedding was perfect. Thanks to the countless hours Edith, her sister, family (both mom and dad), and everyone/thing involved including my mom, sister, brother, and everyone!

We were married on May 4th 2019 under a rustic Chupah with the most gorgeous of weather, outside, surrounded by the most beautiful flower arrangements and smiling faces you could only find in magazines.

Side note about My wife: WHATASMOKESHOW!

Overwhelmed by the amount of love and smiles seeping out of every pore of or our guests and family was the most incredible of experiences. 2 days later we leave for Portugal (May 6th, 2019).

Our plan: tourist stuff for the first few days in Lisbon, rent a car, get lost in the southern part of Portugal, make our way back up to Porto, then fly to the Azores.

The first few days in our beautiful hostel in Lisbon I found myself a bit restless, as I always am when traveling.

I want to see and experience everything!

The next few days I start getting headaches. I write it off as too much delicious wine and stinky cheese, a lot of walking, and not enough water. So I start chugging water before and after bed, taking some pain meds, and hoping I’ll acclimate.

Over the next few days, the headaches got a bit worse.

By day 8 I am popping 800mg Motrin regularly throughout the day to control these terrible migraines I’ve been getting. Again, I chalk it up to port wines, delicious cured meats, and a minor surgery a few days before our honeymoon.

We get back to the US, and the migraines aren’t getting any better. I get through the first week of work without trouble. Once the office has cleared out Thursday evening, I lift up my end-of-day cup of tea and notice my hand shakes ever so slightly.

Now, there are few things I take great pride in: 1. I am the funniest and most humble person I know 2. I found the most wonderful woman on earth, and somehow convinced her to marry me! 3. My hands do not shake. Ever.

Maybe my sleepy-time tea had a little extra caffeine in it? The following morning, I woke up with the migraine already settled. I started getting ready for work (while singing my version of Moana’s You’re Welcome), and I stumbled ever so slightly on my way to the shower. I turned to Edith, and before I can say we are going to the ER, there was a bag packed with goodies, snacks, books,  and fun stuff to do while waiting in the ER already prepared by Edith. (Perks of being married to a nurse).

We stumble into the BWH ER department. They triage us into a room, where the attending, who appeared to be actively trying to avoid eye contact with us, goes “so migraines, huh? You drink caffeine?.” “Uh, sure, but I don’t think this is…” “let’s get him some caffeine pills and some saline.” At this point I mention my history of cancer, and my strong recommendation for a scan. “Sure, let’s get that scan ASAP, and make sure there are no goombas hiding in there.” A quick CT scan and an hour later, I am escorted into the same ER room as before. The same attending bursts in and explains: “So you know those goombas we were checking on? Well, you got some.” This was the last I would ever hear from or see the attending ED Physician. Next enters a very frazzled, kind eyed, neurologist. He ran me Through a thorough neuronexam, and seemed shocked that I am responding as well as I am. He double checks some moves, and finds my only difficulty is “tight rope walking.”

The neurologist then shares that he is so surprised due to the size and location of the tumor. He recommends I go to ICU for monitoring ASAP. After cracking some jokes, and letting the neurologist leave without my usual smart ass remarks, a neurosurgery resident confidently steps into the room. “We need to pluck that guy out of you as soon as possible. If we don’t, you could die. So how does Tuesday morning work? We’d keep you in ICU until then.”

The resident mentions the name of a surgeon, who I immediately “look up” by playing Jewish phone tag and calling one of my longest standing best friends Dr. Sunshine Brem, who followed up by calling  and emailing her father. Dr. Henry Brem, who is not only one of the most caring, selfless, funniest, and wonderful people we got on the planet, but also happens to be a world class neurosurgeon at JHU. Not 15 minutes had passed since my initial inquiry to Sarah, before an older energetic man commends the attention of the ED shouting “who is Mr. Dassa? I have an email here from Henry that I need to see him.” The man was wearing a long white coat, and was waving a flimsy piece of freshly printed printer paper. In comes the head of neurosurgery at BWH. “So, I got an email from my friend Henry. Are you the one with the brain tumor on the left?” “I think so…” The surgeon looks over my images, bluntly and kindly stares me in the eyes and says “you’re not waiting until Tuesday. You are living. We are getting you ready for surgery first thing in the morning.”

More imaging is completed, I am escorted to my all inclusive ICU suite, get pumped full of wonderful drugs, zonked out, then next thing I know, I am being rolled into the OR. Anesthesiologists: “you ready? Me: “just give me the good stuff” Anesthesiologist: “hahaha you got it bud.” I wake up with a minor headache, very thirsty, with a catheter in. In the past, I have pulled nurses in closely and asked to either remove the catheter or euthanatize me. Luckily, neither came to fruition.

After a 2 day recovery, the entire team were shocked to see my balance back, no shaking hands, AND that I could name of the current president of the United States (looks like implementing the “I” word takes longer than removing a brain tumor).

I was dismissed by the hospital, told I’m cleared, but before I pick up a handpiece again, I am taking a week to rest, recoup, and make absolutely sure that my hands and eyes are 100+. Anything less, I can teach dentistry, and/or improv classes.

All in all, doing great. Floored by all the supports and love from everyone! Can not wait to get back, and so happy that I can :)

With love! YD

[kat-the-dog-trainer]

Hi, great blog, I really admire you 🙂 I found a bunny that had been in some sort of accident, he was bleeding and his front right leg was visibly broken. He looked like he was in lots of pain. I took him to my local humane society and they ended up euthanatizing him because his injuries were so severe. Do you think I did the right thing? I just didn't want to see him suffer.

NOTE: I AM SO SORRY IF I NEVER POSTED THIS; I FOUND IT SITTING IN MY DRAFTS.

Yes, I think you did the right thing.

Often with rabbits, treating a broken leg entails one of two things:

1) pins2) amputation

Both of which are accompanied by hefty pain meds and most likely something to prevent gastrointestinal stasis from lack of exercise.This is also not your rabbit (I’m not sure if it’s a wild one?) so what we view as “benevolent human keeps poor critter in their care” can be viewed by the rabbit as “massive semi-hairless ape is keeping me trapped in a small cage”, especially if they are already scared.

With severe injuries, it comes down to quality of life and, whilst people generally want to “KEEP ALL ANIMULS ALIVE UNDER ALL COSTS

[gayassdbz]

Euthanatize me

[healthtimetaylor]

Does age interfere with gadolinium toxicity and presence in brain and bone tissues?

PMID:  Invest Radiol. 2019 02 ;54(2):61-71. PMID: 30394964 Abstract Title:  Does Age Interfere With Gadolinium Toxicity and Presence in Brain and Bone Tissues?: A Comparative Gadoterate Versus Gadodiamide Study in Juvenile and Adult Rats. Abstract:  OBJECTIVES: The main objective of the study was to assess the effect of age on target tissue total gadolinium (Gd) retention after repeated administration of gadodiamide (linear) or gadoterate (macrocyclic) Gd-based contrast agent (GBCA) in rats. The secondary objective was to assess the potential developmental and long-term consequences of GBCA administration during neonatal and juvenile periods.MATERIALS AND METHODS: A total of 20 equivalent human clinical doses (cumulated dose, 12 mmol Gd/kg) of either gadoterate or gadodiamide were administered concurrently by the intravenous route to healthy adult and juvenile rats. Saline was administered to juvenile rats forming the control group. In juvenile rats, the doses were administered from postnatal day 12, that is, once the blood-brain barrier is functional as in humans after birth. The tests were conducted on 5 juvenile rats per sex and per group and on 3 adult animals per sex and per group. T1-weighted magnetic resonance imaging of the cerebellum was performed at 4.7 T during both the treatment and treatment-free periods. Behavioral tests were performed in juvenile rats. Rats were euthanatized at 11 to 12 weeks (ie, approximately 3 months) after the last administration. Total Gd concentrations were measured in plasma, skin, bone, and brain by inductively coupled plasma mass spectrometry. Cerebellum samples from the juvenile rats were characterized by histopathological examination (including immunohistochemistry for glial fibrillary acidic protein or GFAP, and CD68). Lipofuscin pigments were also studied by fluorescence microscopy. All tests were performed blindly on randomized animals.RESULTS: Transient skin lesions were observed in juvenile rats (5/5 females and 2/4 males) and not in adult rats having received gadodiamide. Persisting (up to completion of the study) T1 hyperintensity in the deep cerebellar nuclei (DCNs) was observed only in gadodiamide-treated rats. Quantitatively, a slightly higher progressive increase in the DCN/brain stem ratio was observed in adult rats compared with juvenile rats, whereas no difference was noted visually. In all tissues, total Gd concentrations were higher (10- to 30-fold higher) in the gadodiamide-treated groups than in the gadoterate groups. No age-related differences were observed except in bone marrow where total Gd concentrations in gadodiamide-treated juvenile rats were higher than those measured in adults and similar to those measured in cortical bone tissue. No significant treatment-related effects were observed in histopathological findings or in development, behavior, and biochemistry parameters. However, in the elevated plus maze test, a trend toward an anxiogenic effect was observed in the gadodiamide group compared with other groups (nonsignificant). Moreover, in the balance beam test, a high number of trials were excluded in the gadodiamide group because rats (mainly males) did not completely cross the beam, which may also reflect an anxiogenic effect.CONCLUSIONS: No T1 hyperintensity was observed in the DCN after administration of the macrocyclic GBCA gadoterate regardless of age as opposed to administration of the linear GBCA gadodiamide. Repeated administration of gadodiamide in neonatal and juvenile rats resulted in similar total Gd retention in the skin, brain, and bone to that in adult rats with sex having no effect, whereas Gd distribution in bone marrow was influenced by age. Further studies are required to assess the form of the retained Gd and to investigate the potential risks associated with Gd retention in bone marrow in juvenile animals treated with gadodiamide. Regardless of age, total Gd concentration in the brain and bone was 10- to 30-fold higher after administration of gadodiamide compared with gadoterate.

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