#estrons

[femtechcanadablog]

Get feminized with us get your estrogen feminization started with us

[chicinsilk]

US Vogue July 1957

Wedding dress, in white taffeta, with puffed sleeves; folded hands. Tulle headdress: flat taffeta bow. By Murray Hamburger in Estron acetate taffeta and voile. Blin & Blin wool coat, brown and white checks, seven-eighths long on a Melba toast-colored Lesur wool suit, both by Arthur Jablow. Coffee jersey hat, by Sally Victor. Julianelli shoes.

Robe de mariée, en taffetas blanc, avec des manches bouffantes ; mains de replis. Coiffe en tulle : noeud plat en taffetas. Par Murray Hamburger en taffetas d'acétate Estron et voile. Manteau en laine Blin & Blin, à carreaux marron et blanc, long de sept huitièmes sur un tailleur en laine Lesur couleur toast Melba, tous deux, par Arthur Jablow. Chapeau en jersey café, de Sally Victor. Chaussures Julianelli.

Photo Sante Forlano vogue archive

[luv-lee]

[xanthippethecat]

Pronounce gender hormones like Italian pastas.

[peonypuddles]

Got a new fluorimeter at school and IT RUNS WINDOWS 11 thank fucking god I never have to work out of XP AGAIN

[pizzalexxii]

Hi hello I have arisen in Tumblr once again to share what has been on my mind these past few weeks \o/

Meet my @infamous-if OC, Xia! (stage name) My confident diva queen who is a complete emotional wreck inside </333

Anyway, this scene was during the BOTB auditions,, I rec you play the song below for the vibes wieehee

[autogyne-redacted]

Cyperus Rotundus Report:

There's been some recent buzz about Cyperus Rotundus oil for long term hair removal and I've been doing some digging.

While Cyperus is a well established medicinal herb (and infamous agricultural weed) the only two academic studies that seem to exist on it's role in hair removal are a pair of 2012 and 2014 studies by GF Mohammed, an Egyptian dermatology/sexology/venereology professor. Both follow the same basic methods and show the same basic results:

Cis women with unwanted armpit hair massaged .25mls of distilled Cyperus Rotundus essential oil to the target area twice daily, during the study they plucked hairs from the area every 3 weeks (sugaring or threading) and applied oil immediately after hair removal.

They followed this protocol for 6 months. They were evaluated after 8 months, which was 2 months without the treatment and 1 month after their last hair removal.

Results were shockingly good! Showing a more than 90% hair reduction at that point, statistically equivalent to laser for dark hair and fully effective against white hair that laser isn't effective against. (This is the data for the 2014 study, the 2012 is basically identical just with a larger group and no laser comparison group).

This discussion of potential mechanisms boils down to "Cyperus rotundus is rich in potent components such as flavonoids, lignans, and polyphenols.30-33 Flavonoids and lignans have estrogenic activity that may inhibit 5α-reductase and 17β-hydroxysteroid dehydrogenase via differential transcription activity of an estrogen-response element reporter.34-36 Thus, hair follicles that are entirely androgen dependent can be minimized.1,21,35"

The discussion surrounding these results doesn't tell us much though. There's no discussion of whether or not the author thinks plucking the hair is significant (they just say participants removed hair via "their usual method (sugaring/threading). No discussion of how the dosage was determined or how long results might last/what a long term regiment to maintain results might look like.

Which is to say, maybe it's doing local hormone shit and maybe that's via 5α-reductase and 17β-hydroxysteroid dehydrogenase. Wikipedia tells me 5alpha is tied to steroid metabolism (with both estrogen and androgens) and that 17beta is involved with the " interconversion of DHEA and androstenediol, androstenedione and testosterone, and estrone and estradiol." This is largely beyond me so for now I'm sticking with, "maybe Cyperus Rotundus does some local hormone shit."

Initially I was dismissive of this explanation (after all, lower systemic androgen levels might lighten hair or make it thinner but androgen-activating hair follicles famously persists regardless of androgen levels. But I've seen some studies suggesting that local androgen levels can interact with hair follicles growth stages in some weird ways, including shortening the Anagen growing phase and maybe increasing the time duration of the rest period before a follicle resets to Anagen.

I wasn't able to find much anecdotal evidence and what I could find wasn't over large time periods, but some Reddit reports noted that even after just a week or so it seemed like hairs were coming out from the root when shaving (ie the length of hairs stuck to the raser was substantially longer than the length visible before shaving) and other noted a dramatically increased consistency of plucked hairs have a bulb (a sign that they were in the anagen growth phase before being plucked and that they actually pulled out from the root and didn't break midway).

Hair follicle growth phase and follicle damage is *weird,* I got midway into a deep dive and started losing focus so I'm posting this with less details than I'd like, but I think there's strong evidence that C Rotundus oil in some way affects the growth phases of follicles in a way that suppresses growth (at least short to mid term). It also seems vaguely possible that the oil somehow makes the follicles more susceptible to damage from the hair getting plucked. As I understand it damage to the follicle is far from guaranteed, but happens regularly with plucking. Tho generally it's only enough damage to push the follicle towards being inactive for a period of months and then coming back good as new, not much of a vector for permanent hair elimination.

The fact that results last months after treatment ends is sick. I figure this could suggest that the relevant medicinal compounds just hang around for a long time (if I circle back to this I'll see if there's halflife data on the potentially relevant compounds). If they do hang around on the scale of months than the twice daily application is probably major overkill.

I also think it's feasible (based off my v limited knowledge) that the C Rotundus effect pushes the follicles into an extended rest period, you stop applying the oil and the follicles stay in track to wait out that rest period before activating again.

And ofc there could be a vector for actual permanent hair removal that I just can't think of, but my slightly informed opinion is that that seems unlikely.

.

Side effects are supposed to be basically non-existent (the only object the studies cite is that some ppl don't like the smell of the oil).

I think the main question for me is figuring out what dosing looks like long term. (Do you cycle on and off, do you apply weekly, is daily application most of the time actually important? Etc)

It's also unclear if plucking vs shaving is important. I've been a big fan of epilating lately so that's what I'll be doing and it seems like it should pair nicely with what I expect from C Rotundus but more data from more ppl trying more different shit with this would be rly tight!!

if any of y'all try it out I'd love to hear how it goes <3 <3 <3

Also I probably have the citations for all of the shit I'm referencing around somewhere and can dig them up if anything is of interest.

[catboybiologist]

I stumbled upon a surprisingly recent study on 2 methods of estradiol administration, and the results are baffling, demonstrating transdermal estradiol correlating with a significantly higher decrease in androgen levels when compared with oral-sublingual estradiol. bonkers results, but I'm no biologist, I got no clue if it's quite as "big if true" as it seems

thanks, and hope it's as exciting as I think it is!

https://academic.oup.com/jes/article/8/8/bvae108/7691571

This has generally been known. Any transdermal method is better than sublingual, which is why injections and patches are popular. The usual reasoning for this, however, is that you can increase your effective dose more without stressing out the liver. The method of T suppression from that point is thought to be through pituitary signaling.

I gave the paper a quick buzz through but not an extensive read. Increased suppression at the same circulating estradiol level is interesting. The estrone might matter, delivery to the pituitary might matter. I'll think about it. Imma see if I can get a sense of it based on that paper and estrogen signalling in general.

[mortalityplays]

How do you make a whore moan?

Extract sapogenins from a Mexican yam and employ Marker degradation to degrade the sapogenin side chain while leaving similar functional groups on the steroid nucleus (relatively) unaffected. Use acetic anhydride to block the hydroxyl group formed by opening the six-membered pyran ring. Then oxidatively open the five-membered furan ring with chromic acid. This forms the acetyl side chain of progesterone and an esterified hydroxyl group on the steroid nucleus. The ester is then hydrolyzed under strongly basic conditions. The use of acetic acid leads to the production of 16-dehydropregnenolone acetate (16-DPA). 16-DP can be converted into progesterone in two steps. Firstly, the double bond in ring D is hydrogenated, followed by Oppenauer oxidation of the hydroxyl group and the concurrent migration of the remaining olefin from ring B to ring A so that it is in conjugation with the ketone carbonyl group at position 3. Alternatively, a three-step procedure involving Br2, CrO3, and Zn/HOAc can be used. 16-DP can also be converted into testosterone and the downstream products estrone and estradiol. 👍

[clowncaraz-journal]

hrt for transspecies folk:

Biotin or keratin, LAC (mix of lavender, almond, cedarwood oil(topical only)), HCG, Estrone, DHEA, DHT

modding for transspecies folk:

attaching, elfing, fangsmithing, suiting (yes these are real things)

[femtechcanadablog]

Kickstart your feminization journey with us at femtech canada organization All kinds of feminization products are available at affordable prices.just dm me.

[chicinsilk]

US Vogue November 1, 1952

Dovima wears a buttery beige crepe afternoon dress, with a loose buckle belt that falls from the waist, not up. By Talmack, in Bianchini crepe (wool with Estron acetate)

Dovima porte une robe d'après-midi en crêpe beige beurre, avec une ceinture à boucle lâche descendant de la taille, pas vers le haut. Par Talmack, en crêpe Bianchini (laine avec acétate d'Estron)

Photo Norman Parkinson vogue archive

[i-am-a-fan]

you’re telling me these isomers use they/them pronouns?

[squelsh]

we should put cats on human estrogens to see what happens. like, okay i think we have the same primarye estrogens (estradiol 17b?) and i only really take estradiol and consider myself done with it so maybe like, our estrone is different to cats and we should give them that so it's actually human unique for them? is our estriol unique? 1.5mg estriol daily. okay i'm still not over the fact that actually we probably have almost identical estrogens to felidaes. fucking, 4-OHE2? do they have that? probably. okay 0.5mg estradiol twice daily and we check to see that they're okay. and then we can get the go-ahead to put the cat-unique estrogens in people. fuck wait don't most domestic cats not even produce estrogens in any meaningful amount after being spayed? the cat hrt surely can't just mean menopause, right. i'm asking for 6 billion dollars

[musicblogwales]

WRKHOUSE unveil fantastic new video - 'Take' is Out Now!

North Wales band WRKHOUSE release hard-hitting new single 'Take', which is available now via all streaming dsp's and youtube. The track delivers deliciously distorted bass-lines and pulsing synth leads that translate into an anthemic and uplifting single.

A stand alone single, ‘Take’ will also be included on the bands upcoming extended version of their debut EP  ‘Out Of The Blue’. The release is accompanied by a striking new music video by long-time collaborator Aled Victor. 

Recorded at the same time as the band’s debut EP, the track comes amid a wave of critical acclaim with support from the likes of BBC Radio Wales (Welsh A-List), BBC Radio 1, Clash, Selector Radio, Atwood Magazine and God Is In The TV among others, the band pull influences from a diverse array of Indie pioneers such as Foals, Nothing But Thieves, and Talking Heads (to name a few), the full EP delves into themes of liberation from the constraints of one's life, whether it be in relationships, self-discovery, or artistic expression. 

The new single ‘Take’ showcases the more angsty and post-punk flavoured side of the band’s sound, leaning on political themes. Built around punching drums and a wall of fuzzy, overdriven bass and guitar tones, the track journeys through its urgent and expressive, spoken word verse to its infectious and anthemic chorus. Working with acclaimed producers Ed Al-Shakarchi (Boy Azooga, The Bug Club, Loathe), Steffan Pringle (Adwaith, Estrons) and Mark Gardener (Ride), the tracks production captures both the bands raw, intense energy whilst also delivering a polished and radiantly complete sound. 

Talking about the track and the upcoming extended EP release the band explained “We’d sat with the instrumental for a long time - it was the first of the tracks to be recorded, but it was a struggle initially to give it a story that aligned with the rest of the EP. Eventually we felt urged to express a certain kind of message in the lyrics, that felt like it needed its separate moment.”

WRKHOUSE have had a breakthrough year with the release of their long-awaited debut EP, Out of the Blue boasting invigorating hooks, vast arrangements, and textural echoes of their upbringing in North Wales. Both an awardee of the 2024 BBC Horizons Launchpad Fund and also winners of a 2024 Welsh Music Prize Triskel Award, WRKHOUSE have quickly gathered pockets of loyal fans across the country, having just finished a packed out debut headline UK launch tour and being named among BBC Cymru Fyw’s ‘top five artists to watch’. Their brand of groove-heavy alt-pop places them firmly among Wales’ newest generation of exciting emerging acts. This autumn, WRKHOUSE introduce the final chapter of their Out of the Blue journey.  ‘Take’ is out now on all DSP's.

DISCOVER WRKHOUSEInstagram @wrkhousewrkhouseTiktok @wrkhousewrkhouseYoutube @wrkhousewrkhouseFacebook @wrkhouseTwitter - @wrkhouseeeBandcamp - BandcampLinktree - https://linktr.ee/wrkhouse

[sillybouquetoflillies]

estronized n full of chicken ^-^