#estrons

[chicinsilk]

US Vogue July 1957

Wedding dress, in white taffeta, with puffed sleeves; folded hands. Tulle headdress: flat taffeta bow. By Murray Hamburger in Estron acetate taffeta and voile. Blin & Blin wool coat, brown and white checks, seven-eighths long on a Melba toast-colored Lesur wool suit, both by Arthur Jablow. Coffee jersey hat, by Sally Victor. Julianelli shoes.

Robe de mariée, en taffetas blanc, avec des manches bouffantes ; mains de replis. Coiffe en tulle : noeud plat en taffetas. Par Murray Hamburger en taffetas d'acétate Estron et voile. Manteau en laine Blin & Blin, à carreaux marron et blanc, long de sept huitièmes sur un tailleur en laine Lesur couleur toast Melba, tous deux, par Arthur Jablow. Chapeau en jersey café, de Sally Victor. Chaussures Julianelli.

Photo Sante Forlano vogue archive

[luv-lee]

[xanthippethecat]

Pronounce gender hormones like Italian pastas.

[peonypuddles]

Got a new fluorimeter at school and IT RUNS WINDOWS 11 thank fucking god I never have to work out of XP AGAIN

[pizzalexxii]

Hi hello I have arisen in Tumblr once again to share what has been on my mind these past few weeks \o/

Meet my @infamous-if OC, Xia! (stage name) My confident diva queen who is a complete emotional wreck inside </333

Anyway, this scene was during the BOTB auditions,, I rec you play the song below for the vibes wieehee

[clowncaraz]

Deviæ - Deviæsis - Deviatypal

An adjective to a variation where your physical sex traits are considered unnatural, artificial, or animalistic in nature.

Can be considered this way due to:

HRT or Surgery

Body Modification

Tattoos

Physical Biokinesis/Postfurry Identity

Physical Nonhumanity (Only Physical)

Transhumanist Appendages

Transspecies Transition

Misceverse Transition

Examples:

a transspecies canine getting a knot by use of body modification/beading

disembodied transhuman genitalia that allow for direct stimulation

miscverse scent implants in the skin

tattoos for markings, scales, etc

hormones like HCG, Estrone, DHEA, DHT

animalizing surgery

use of subliminals, exercise, and exposure to nonhumanity

genitalia sleaving

Terminology:

Deviborn/ ANBS - Born with deviatypal traits/ "Assigned Nonhuman By Society"

Cisspecieal - Someone who's species aligns with what was assigned to them by society

HtA/ HtB - Human to Animal/ Human to Beast

Species Dysphoria - Dysphoria that affects the perception of species

Non-dichomy - Those not aligned in the animal/beast or human category

Malspecialia - Affirmation of deviæ identity for the sole purpose of attacking or discrimination

Species expression - The expression of species traits through clothing, terms, names, etc

Vocalization Training - non-surgical method helping with speaking in or around the tone, sounds, or pitch of their species

Tail Creation - The attachment of a tail to the spine permanently or frequently

@radiomogai

@beyond-mogai-pride-flags

@transspeciesculture

[autogyne-redacted]

Cyperus Rotundus Report:

There's been some recent buzz about Cyperus Rotundus oil for long term hair removal and I've been doing some digging.

While Cyperus is a well established medicinal herb (and infamous agricultural weed) the only two academic studies that seem to exist on it's role in hair removal are a pair of 2012 and 2014 studies by GF Mohammed, an Egyptian dermatology/sexology/venereology professor. Both follow the same basic methods and show the same basic results:

Cis women with unwanted armpit hair massaged .25mls of distilled Cyperus Rotundus essential oil to the target area twice daily, during the study they plucked hairs from the area every 3 weeks (sugaring or threading) and applied oil immediately after hair removal.

They followed this protocol for 6 months. They were evaluated after 8 months, which was 2 months without the treatment and 1 month after their last hair removal.

Results were shockingly good! Showing a more than 90% hair reduction at that point, statistically equivalent to laser for dark hair and fully effective against white hair that laser isn't effective against. (This is the data for the 2014 study, the 2012 is basically identical just with a larger group and no laser comparison group).

This discussion of potential mechanisms boils down to "Cyperus rotundus is rich in potent components such as flavonoids, lignans, and polyphenols.30-33 Flavonoids and lignans have estrogenic activity that may inhibit 5α-reductase and 17β-hydroxysteroid dehydrogenase via differential transcription activity of an estrogen-response element reporter.34-36 Thus, hair follicles that are entirely androgen dependent can be minimized.1,21,35"

The discussion surrounding these results doesn't tell us much though. There's no discussion of whether or not the author thinks plucking the hair is significant (they just say participants removed hair via "their usual method (sugaring/threading). No discussion of how the dosage was determined or how long results might last/what a long term regiment to maintain results might look like.

Which is to say, maybe it's doing local hormone shit and maybe that's via 5α-reductase and 17β-hydroxysteroid dehydrogenase. Wikipedia tells me 5alpha is tied to steroid metabolism (with both estrogen and androgens) and that 17beta is involved with the " interconversion of DHEA and androstenediol, androstenedione and testosterone, and estrone and estradiol." This is largely beyond me so for now I'm sticking with, "maybe Cyperus Rotundus does some local hormone shit."

Initially I was dismissive of this explanation (after all, lower systemic androgen levels might lighten hair or make it thinner but androgen-activating hair follicles famously persists regardless of androgen levels. But I've seen some studies suggesting that local androgen levels can interact with hair follicles growth stages in some weird ways, including shortening the Anagen growing phase and maybe increasing the time duration of the rest period before a follicle resets to Anagen.

I wasn't able to find much anecdotal evidence and what I could find wasn't over large time periods, but some Reddit reports noted that even after just a week or so it seemed like hairs were coming out from the root when shaving (ie the length of hairs stuck to the raser was substantially longer than the length visible before shaving) and other noted a dramatically increased consistency of plucked hairs have a bulb (a sign that they were in the anagen growth phase before being plucked and that they actually pulled out from the root and didn't break midway).

Hair follicle growth phase and follicle damage is *weird,* I got midway into a deep dive and started losing focus so I'm posting this with less details than I'd like, but I think there's strong evidence that C Rotundus oil in some way affects the growth phases of follicles in a way that suppresses growth (at least short to mid term). It also seems vaguely possible that the oil somehow makes the follicles more susceptible to damage from the hair getting plucked. As I understand it damage to the follicle is far from guaranteed, but happens regularly with plucking. Tho generally it's only enough damage to push the follicle towards being inactive for a period of months and then coming back good as new, not much of a vector for permanent hair elimination.

The fact that results last months after treatment ends is sick. I figure this could suggest that the relevant medicinal compounds just hang around for a long time (if I circle back to this I'll see if there's halflife data on the potentially relevant compounds). If they do hang around on the scale of months than the twice daily application is probably major overkill.

I also think it's feasible (based off my v limited knowledge) that the C Rotundus effect pushes the follicles into an extended rest period, you stop applying the oil and the follicles stay in track to wait out that rest period before activating again.

And ofc there could be a vector for actual permanent hair removal that I just can't think of, but my slightly informed opinion is that that seems unlikely.

.

Side effects are supposed to be basically non-existent (the only object the studies cite is that some ppl don't like the smell of the oil).

I think the main question for me is figuring out what dosing looks like long term. (Do you cycle on and off, do you apply weekly, is daily application most of the time actually important? Etc)

It's also unclear if plucking vs shaving is important. I've been a big fan of epilating lately so that's what I'll be doing and it seems like it should pair nicely with what I expect from C Rotundus but more data from more ppl trying more different shit with this would be rly tight!!

if any of y'all try it out I'd love to hear how it goes <3 <3 <3

Also I probably have the citations for all of the shit I'm referencing around somewhere and can dig them up if anything is of interest.

[mortalityplays]

How do you make a whore moan?

Extract sapogenins from a Mexican yam and employ Marker degradation to degrade the sapogenin side chain while leaving similar functional groups on the steroid nucleus (relatively) unaffected. Use acetic anhydride to block the hydroxyl group formed by opening the six-membered pyran ring. Then oxidatively open the five-membered furan ring with chromic acid. This forms the acetyl side chain of progesterone and an esterified hydroxyl group on the steroid nucleus. The ester is then hydrolyzed under strongly basic conditions. The use of acetic acid leads to the production of 16-dehydropregnenolone acetate (16-DPA). 16-DP can be converted into progesterone in two steps. Firstly, the double bond in ring D is hydrogenated, followed by Oppenauer oxidation of the hydroxyl group and the concurrent migration of the remaining olefin from ring B to ring A so that it is in conjugation with the ketone carbonyl group at position 3. Alternatively, a three-step procedure involving Br2, CrO3, and Zn/HOAc can be used. 16-DP can also be converted into testosterone and the downstream products estrone and estradiol. 👍

[i-am-a-fan]

you’re telling me these isomers use they/them pronouns?

[squelsh]

we should put cats on human estrogens to see what happens. like, okay i think we have the same primarye estrogens (estradiol 17b?) and i only really take estradiol and consider myself done with it so maybe like, our estrone is different to cats and we should give them that so it's actually human unique for them? is our estriol unique? 1.5mg estriol daily. okay i'm still not over the fact that actually we probably have almost identical estrogens to felidaes. fucking, 4-OHE2? do they have that? probably. okay 0.5mg estradiol twice daily and we check to see that they're okay. and then we can get the go-ahead to put the cat-unique estrogens in people. fuck wait don't most domestic cats not even produce estrogens in any meaningful amount after being spayed? the cat hrt surely can't just mean menopause, right. i'm asking for 6 billion dollars

[heartshapedgreen]

re: last rb, i have so much to say about the demonization of androgens & the way hyperandrogenism intersexies are kind of regurgitating that by taking their diagnosis and biased researches for granted. dyadist research will usually mention androgen excess and estrogen excess in isolation from the other hormone, nothing about progesterone or estrone, or the fact we all have these hormones working together in different ways, we all have a menstrual cycle (yes, even those who don't bleed - that's just one symptom of a period - and the "male cycle" which centers testosterone cycling every 24 hours is bs cause everyone's testosterone - usually - does that) AND your menstrual cycle is as unique to you as your fingerprint. that's why we all look so different.

like i grew up with high levels of androgens, had a precocious puberty & i'm now going thro puberty no. 2. i suspect high levels of estrogen (relative to my progesterone, everyone forgets her) with androgens prolly decreasing because My God The Pain™️ (& i have very high pain tolerance). i recently developed incontinence issues and really bad pelvic floor dysfunction with chronic pelvic pain. testosterone deficiency leads to chronic pain btw & testosterone is known to help with cfs and fibro. personally increasing my probiotics & fiber has helped immensely (you poop out excess estrogen, and i have ibs-c LOL).

having dealt with dysfunction with both the 'mones, i have to say i much prefer my baby days of growing body hair at 7y/o rather than severe pelvic pain where i can't move and have to do postnatal physiotherapy for it. & knowing i'm just going to get worse and worse with age. my fertile family members would pop out babies every year to stop the symptoms of hyperestrogenism btw. what financial insecurity and no medicalcare does to a bitch.

anyways. what they don't tell you is that androgens and estrogens are both pro inflammatory & anti inflammatory + they work in tandem, and estrogen dominance can be a Bitch. & the virilization that comes with, for ex, PCOS? that's from androgen secreted from the ovarian cysts (which can secrete estrogen too & that's also not good). the androgen excess is a consequence, not a cause. acne, hirsutism, menstruation irregularities are consequences of the inflammatory processes.

and those cysts? most likely caused from various dysfunctions in the body. i'm not a doc (thank god), but something something metabolic dysfunction something. the thing about androgen (and estrogen) being pro iflammation? it becomes a feedback loop of inflammation > high levels of androgen/estrogen secreted > More inflammation. working on the root cause, decreasing inflammation (whatever this means for you) is more likely to help than the way fatphobic and interphobic docs will tell you to lose weight or reduce your testosterone. you also need your testosterone. hirsutism is not the be all end all.

[sillybouquetoflillies]

estronized n full of chicken ^-^

[sylestial]

lmao I asked my doctor to test my estrone levels for the first time last appointment. the results came in today and it was at S I X H U N D R E D pg/ml. looks like I'm switchin to shots!

[fatal---femme]

new trans woman music genre called (prog)estrone rock

[omegaremix]

Omega Radio for August 11, 2018; #170.

End Of A Year / Self Defense Family “Self-Immolation Family”

Bethlehem Steel “Florida 2”

Still Corners “The Photograph”

Eternal Summers “Famous Last Words”

Aa “Homecoming”

Dead Hearts Club “Dead Friends”

H.Grimace “In The Body”

Heads. “At The Coast”, “Urges”

Swearin’ “Grow Into A Ghost”

Hot Flash Heat Wave “Glo Ride”

Palm “Dog Milk”

Water From Your Eyes “We’re Set Up”

Charcoal Owls “225 Says You’ll Stay”

Viet Cong / Preoccupations “Disarray”

Rolling Blackouts Coastal Fever “An Air Conditioned Man”, “Time In Common”

Wild Nothing “Letting Go”

Beastmilk / Grave Pleasures “Love In A Cold World”, “Strange Attractors”

Shopping “Suddenly Gore”

Soft Kill “Trying Not To Die”

Estrons “I’m Not Your Girl”, “Cameras”

Corridor “Le Grand Ecart”

Lotus Plaza “Strangers”

Idles “Samaritans”, “Danny Nedelko”

Menace Beach “Black Rainbow Sound”

Deluxe Summer and colorful indie.

[autogyne-redacted]

The thing that's so cool about sublingual is that if you have access to taking e oral you have access to taking it sublingually (or buchal). Like some ppl don't like needles and suppositories aren't everyone's cup of tea but literally you just let your pills hang out in your mouth for longer and you get more estradiol actually in your system.

Like the only reasons against it (**compared to oral**) are if you really hate your e peaking, you actively want more estrone (which I would be unusual), or you just can't handle something tasty hanging out in your mouth for a little bit. (You could also want a lower e level but like just take less if that's your issue with sublingual tbh)

From here, this newer studies and studies on trans women give similar results this one just has a graph.