#enantiomers

[connieaaa]

I was at the Snohomish County EMS conference yesterday and there was a super interesting lecturer named William Heuser, he is a clinical pharmacist and toxicologist, as well as a critical care flight paramedic. I was warned ahead of time that the lecture would "knock your socks off", but was surprised because he spoke like a fire and brimstone Pentecostal preacher but he was yelling about about traumatic brain injuries and intubation sequences medications. It was so cool, after the lecture I go up to him and ask "Can you autograph my chemistry homework? It the only thing I have available."

He said yes, and then glanced at the paper and said "Oh, you are learning about ecgonine - you must be studying Organic Chemistry."

Me: "Yes, it was exciting during your lecture when you brought up s-ketamine vs racemic ketamine I was like "oh he is talking about enantiomers!""

Him: "You know what enantiomers are! I trained in Oganic Chemistry so I think that's awesome, most people don't want I am talking about. Good luck on your studies."

[tenth-sentence]

The maximum number of stereoisomers possible for this molecule is 2ⁿ = 2² = 4, each of which is drawn in figure 17.20.

"Chemistry" 2e - Blackman, A., Bottle, S., Schmid, S., Mocerino, M., Wille, U.

[whats-in-a-sentence]

The over-the-counter drug ibuprofen (an analgesic sold under various names including Nurofen®, figure 17.19), for example, shows enantiomerism and can exist as the following pair of enantiomers:

"Chemistry" 2e - Blackman, A., Bottle, S., Schmid, S., Mocerino, M., Wille, U.

[oh-dear-so-queer]

Again, 2-methylcyclohexanol has two stereocentres and exists as 2² = 4 stereoisomers, with the cis isomer as one pair of enantiomers and the trans isomer as a second pair:

"Chemistry" 2e - Blackman, A., Bottle, S., Schmid, S., Mocerino, M., Wille, U.

[homeostasister]

Gonna start using enantiomer terminology to talk about everyday chiral objects.

Ugh, all our bread knives are R configuration. I wish we had a racemic mixture so I could pick a knife with the right chirality to actually use the serrated edge without having to cut towards myself.

[underagetigerdrinker]

[hanbon2023]

Chiral Separation

Chiral separation is the process of separating enantiomers, which are mirror-image isomers of a molecule that cannot be superimposed onto each other. Enantiomers possess identical physical and chemical properties but exhibit different biological activities. Chiral separation is crucial in fields such as pharmaceuticals, agrochemicals, and fine chemicals, where the specific enantiomeric form of a molecule may have different effects or interactions in biological systems.

Types of Chiral Separation

Preparative Liquid Chromatography System

The Hanbon preparative liquid chromatography system finds widespread application in the separation and purification of a diverse range of substances, including pharmaceutical intermediates, biopharmaceuticals, synthetic drugs, natural products, fine chemicals, and food additives.

Chromatographic Column

Hanbon offers a range of medium and high-pressure chromatography columns, including laboratory columns and DAC (dynamic axial compression) columns.

Simulated Moving Bed (SMB)

In 2005, Hanbon introduced the innovative DAC® (dynamic axial compression) column, which incorporates iSMB (simulated moving bed) technology.

Continuous Ion Exchange Chromatography

Continuous dissociation technology is a powerful combination of standard fixed resin bed technology and continuous counter-current systems.

SFC (Supercritical Fluid Chromatography)

Supercritical Fluid Chromatography (SFC) is a powerful chromatographic technique that utilizes supercritical fluids as the mobile phase.

How Does Chiral Chromatography Work?

Chiral chromatography relies on the use of a chiral stationary phase, which is a solid or liquid material capable of differentiating between enantiomers. The chiral stationary phase interacts selectively with the enantiomers, leading to differences in their retention times or elution orders. This separation is based on the differences in their molecular interactions, such as stereoselective adsorption or formation of inclusion complexes.

[kagrenacs]

I wonder where the name Meridia came from. I'm reading about Meridional energy transfer, the transfer of energy from the equator, North and Southwards to the poles along a gradient. And that sounds similar to her sphere. :0

[kyannnite]

bingge vs. bingmei

[pennyhelpsmestudy]

I’ve been on spring break recently, so there wasn’t much to post.

Studying for my second exam, and I’m really struggling with enantiomers and meso compounds. Any tips? I feel like I’ve watched every video on the subject.

[theonpilled]

beautiful lesson at smelling class

[gayleafpool]

ochem is the funniest subject. why did they call it a backside attack

[tenth-sentence]

The trans isomer is chiral and exists as a pair of enantiomers.

"Chemistry" 2e - Blackman, A., Bottle, S., Schmid, S., Mocerino, M., Wille, U.

[whats-in-a-sentence]

A classic example of a coordination complex (see chapter 13) that can exist as enantiomers is the golden-yellow [Co(en)3]³+ ion (figure 17.13).

"Chemistry" 2e - Blackman, A., Bottle, S., Schmid, S., Mocerino, M., Wille, U.

[oh-dear-so-queer]

Similarly, 3-methylcyclohexanol contains two stereocentres and exists as 2² = 4 stereoisomers, with the cis isomer as one pair of enantiomers and the trans isomer as a second pair:

"Chemistry" 2e - Blackman, A., Bottle, S., Schmid, S., Mocerino, M., Wille, U.

[edge-oftheworld]

can we please appreciate the L-hemoglobin joke more