#cheap travel coronavirus

[lenbryant]

(Times) This May Be Our Last Chance to Halt Bird Flu in Humans, and We Are Blowing It

The outbreak of H5N1 avian influenza among U.S. dairy cows, first reported on March 25, has now spread to at least 33 herds in eight states. On Wednesday, genetic evidence of the virus turned up in commercially available milk. Federal authorities say the milk supply is safe, but this latest development raises troubling questions about how widespread the outbreak really is.

So far, there is only one confirmed human case. Rick Bright, an expert on the H5N1 virus who served on President Biden’s coronavirus advisory board, told me this is the crucial moment. “There’s a fine line between one person and 10 people with H5N1,” he said. “By the time we’ve detected 10, it’s probably too late” to contain.

That’s when I told him what I’d heard from Sid Miller, the Texas commissioner for agriculture. He said he strongly suspected that the outbreak dated back to at least February. The commissioner speculated that then as many as 40 percent of the herds in the Texas Panhandle might have been infected.

Dr. Bright fell silent, then asked a very reasonable question: “Doesn’t anyone keep tabs on this?”

The H5N1 outbreak, already a devastating crisis for cattle farmers and their herds, has the potential to turn into an enormous tragedy for the rest of us. But having spent the past two weeks trying to get answers from our nation’s public health authorities, I’m shocked by how little they seem to know about what’s going on and how little of what they do know is being shared in a timely manner.

How exactly is the infection transmitted between herds? The United States Department of Agriculture, the Food and Drug Administration and the Centers for Disease Control and Prevention all say they are working to figure it out.

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According to many public health officials, the virus load in the infected cows’ milk is especially high, raising the possibility that the disease is being spread through milking machines or from aerosolized spray when the milking room floors are power washed. Another possible route is the cows’ feed, owing to the fairly revolting fact that the U.S. allows farmers to feed leftover poultry bedding material — feathers, excrement, spilled seeds — to dairy and beef cattle as a cheap source of additional protein.

Alarmingly, the U.S.D.A. told me that it has evidence that the virus has also spread from dairy farms back to poultry farms “through an unknown route.” Well, one thing that travels back and forth between cattle farms and chicken farms is human beings. They can also travel from cattle farms to pig farms, and pigs are the doomsday animals for human influenza pandemics. Because they are especially susceptible to both avian and human flu, they make for good petri dishes in which avian influenza can become an effective human virus. The damage could be vast.

The U.S.D.A. also told me it doesn’t know how many farmers have tested their cattle and doesn’t know how many of those tests came up positive; whatever testing is being done takes place at the state level or in private labs. Just Wednesday, the agency made it mandatory to report all positive results, a long overdue step that is still — without the negative results alongside them — insufficient to give us a full picture. Also on Wednesday, the U.S.D.A. made testing mandatory for dairy cattle that are being moved from one state to another. It says mandatory testing of other herds wouldn’t be “practical, feasible or necessarily informative” because of “several reasons, ranging from laboratory capacity to testing turnaround times.” The furthest the agency will go is to recommend voluntary testing for cattle that show symptoms of the illness — which not all that are infected do. Dr. Bright compares this to the Trump administration’s approach to Covid-19: If you don’t test, it doesn’t exist.

As for the F.D.A., it tells me it hasn’t completed specific tests to confirm that pasteurization would make milk from infected cows safe, though the agency considers it “very likely” based on extensive testing for other pathogens. (It is not yet clear whether the elements of the H5N1 virus that recently turned up in milk had been fully neutralized.) That testing should have been completed by now. In any case, unpasteurized milk remains legal in many states. Dr. Bright told me that “this is a major concern, especially given recent infections and deaths in cats that have consumed infected milk.”

Making matters worse, the U.S.D.A. failed to share the genomes from infected animals in a timely manner, and then when it shared the genomes did so in an unwieldy format and without any geographic information, causing scientists to tear their hair out in frustration.

All this makes catching potential human cases so urgent. Dr. Bright says that given a situation like this, and the fact that undocumented farmworkers may not have access to health care, the government should be using every sophisticated surveillance technique, including wastewater testing, and reporting the results publicly. That is not happening. The C.D.C. says it is monitoring data from emergency rooms for any signs of an outbreak. By the time enough people are sick enough to be noticed in emergency rooms, it is almost certainly too late to prevent one.

So far, the agency told me, it is aware of only 23 people who have been tested. That tiny number is deeply troubling. (Others may be getting tested through private providers, but if negative, the results do not have to be reported.)

On the ground, people are doing the best they can. Adeline Hambley, a public health officer in Ottawa, Mich., told me of a farm whose herd had tested positive. The farm owner voluntarily handed over the workers’ cellphone numbers, and the workers got texts asking them to report all potential symptoms. Lynn Sutfin, a public information officer in the Michigan Department of Health and Human Services, told me that response rates to those texts and other forms of outreach can be as high as 90 percent. That’s heartening, but it’s too much to expect that a poor farmworker — afraid of stigma, legal troubles and economic loss — will always report even mild symptoms and stay home from work as instructed.

It’s entirely possible that we’ll get lucky with H5N1 and it will never manage to spread among humans. Spillovers from animals to humans are common, yet pandemics are rare because they require a chain of unlucky events to happen one after the other. But pandemics are a numbers game, and a widespread animal outbreak like this raises the risks. When dangerous novel pathogens emerge among humans, there is only a small window of time in which to stop them before they spiral out of control. Neither our animal farming practices nor our public health tools seem up to the task.

There is some good news: David Boucher, at the federal government’s Administration for Strategic Preparedness and Response, told me that this virus strain is a close match for some vaccines that have already been formulated and that America has the capacity to manufacture and potentially distribute many millions of doses, and fairly quickly, if it takes off in humans. That ability is a little like fire insurance — I’m glad it exists, but by the time it comes into play your house has already burned down.

I’m sure the employees of these agencies are working hard, but the message they are sending is, “Trust us — we are on this.” One troubling legacy of the coronavirus pandemic is that there was too much attention on telling the public how to feel — to panic or not panic — rather than sharing facts and inspiring confidence through transparency and competence. And four years later we have an added layer of polarization and distrust to work around.

In April 2020, the Trump administration ousted Dr. Bright from his position as the director of the Biomedical Advanced Research and Development Authority, the agency responsible for fighting emerging pandemics. In a whistle-blower complaint, he alleged this happened after his early warnings against the coronavirus pandemic were ignored and as retaliation for his caution against unproven treatments favored by Donald Trump.

Dr. Bright told me that he would have expected things to be much different during the current administration, but “this is a live fire test,” he said, “and right now we are failing it.”

Zeynep Tufekci (@zeynep) is a professor of sociology and public affairs at Princeton University, the author of “Twitter and Tear Gas: The Power and Fragility of Networked Protest” and a New York Times Opinion columnist. @zeynep • Facebook

A version of this article appears in print on April 28, 2024, Section SR, Page 9 of the New York edition with the headline: The U.S. Is Blowing Its Chance to Halt Bird Flu in Humans. Order Reprints | Today’s Paper | Subscribe

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[digiroadsabhisheksaini]

The Art of Flavour Making: Qatar is a nation known not only for its stunning architecture and bustling economy but also for its rich culinary heritage.

 It is located in the middle of the Middle East, where culture, tradition, and innovation meet. Qatar has a growing food service market. Qatar has become a thriving centre for gastronomic experiences thanks to a remarkable rise in the food service industry over the past few years. The Qatar Food Service Market has developed into a dynamic landscape that caters to the diverse culinary preferences of Qataris and expats alike, offering everything from traditional Qatari fare to international fare.

The Ascent of Qatar's Food Service Market

The development of Qatar's food Service market can be credited to a few elements. Qatar's, right off the bat's, quickly growing populace, driven by a roaring economy and a convergence of ostracises, has encouraged an exorbitant interest for different eating choices. Subsequently, business people and established café networks have jumped all over the chance to lay out their presence in the nation, adding to a dynamic culinary scene.

Qatar's Service has been proactive in advancing the travel industry and accommodation, facilitating significant occasions, for example, the FIFA World Cup 2022. In addition to putting Qatar on the map globally, these initiatives have prompted investments in the food service industry, which includes food trucks, cafes, and restaurants.

High-end restaurants and gourmet eateries have also emerged as a result of Qatar's affluent population's preference for high-end dining experiences. These establishments frequently combine modern culinary techniques with traditional Qatari flavours, appealing to both local foodies and visitors from abroad looking for an elevated dining experience.

Key Players and Trends in the Qatar Food Service Market is characterised by a wide range of players, from independent restaurants to multinational chain restaurants. Nearby business visionaries have gained by Qatar's rich culinary legacy, offering credible Qatari dishes like Machbous (flavoured rice with meat) and Thareed (a stew-like dish with bread). These establishments represent Qatar's culture by maintaining Qatar's culinary heritage while adapting to contemporary tastes.

Simultaneously, global eatery networks have laid out major areas of strength for an in Qatar's food Service market, taking care of the inclinations of a cosmopolitan customers. From cheap food monsters to upscale feasting foundations, these chains offer many cooking styles, including American, Italian, Asian, and Center Eastern, mirroring Qatar's status as a mixture of societies.

Notwithstanding conventional physical eateries, food conveyance Services have acquired colossal notoriety in Qatar, driven by accommodation and changing shopper inclinations. Food delivery apps and platforms have grown at an exponential rate, giving customers access to a wide range of cuisines from the convenience of their offices or homes.

In addition, supportability and wellbeing cognizant feasting have arisen as critical patterns in Qatar's food Service market. Catering to the preferences of consumers who care about the environment and their health, restaurants and cafes are increasingly including plant-based options, organic produce, and ingredients sourced locally on their menus.

Opportunities and Challenges In spite of its rapid expansion, Qatar's food service market faces a number of obstacles, such as rising operating costs, increased competition, and regulatory requirements. Aspiring restaurateurs, particularly small businesses and startups, may face significant barriers to entry due to high real estate and labour costs.

Besides, the Coronavirus pandemic has introduced remarkable difficulties to the food Service industry, with impermanent terminations, limitations on eating limit, and changes in shopper conduct affecting organisations no matter how you look at it. Online ordering, contactless delivery, and improved safety protocols are just a few of the innovative strategies that tenacious business owners have used to overcome these obstacles.

Looking forward, Qatar's food Service market is ready to proceed with development and advancement. Entrepreneurs can take advantage of the growing demand for one-of-a-kind culinary experiences as the nation gets ready to host major events and draw tourists from all over the world. By embracing innovation, supportability, and social variety, Qatar's food Service industry is set to flourish in the years to come, reaffirming the country's status as a worldwide gastronomic objective.

[theorist-influencer-untitled]

4.21.24 Sunday

2:37 am

I still have windblow... Hmmm... Weird... I already posted here about my view on getting pregnant... But we all have our own views about life....Life is a case by case and sometimes the situation that applicable on other people, might not applicable on you...

For the judgemental, mind your own lives and stop judging people....We all have our own definition of LIFE and RIGHTS. We all have RIGHTS or FREEWILL...

I'm not liberated nor ultra-conservative... I'm conserberated...

My life before was different on my life now....Our family is in chaos, we are not ohkay coz of what they did to me for 17 years. Aside from other people and some old friends that are missing... Weird!!!

If ever on example if Pilot Garret is here... My example subject matter....I really like him when I first saw him on youtube...

If the topic or question if I want to have a child, yeah! But it is it depends on the situation... But I want to have one supposed to be but there is part of me that I'm between ready and not ready... This is difficult to explain....I have windblow...

But sometimes I'm worrying... I know, I'm religious enough... I'm 44 on my first life, on my repeat I'm only 17 on my 2nd life ( My cat side will come out ) hahah but originally my nature wasn't rude or wasn't mean...

I feel bad and I feel old and I truly feel fat and ugly....Yeah! There are so many 17 years old right now who already got some lines on their faces coz they wanted to be the older person or their situation stressed them out so much or someone is stressing her unfairly.

I don't know if the windblow will be good to me, if the time comes that I'm ready to have a child...

I remember Mike Shawn the one that I met in cuddle-lite from last year but the app just lasted for 4 years, then it was closed last year....The app which you can only have voices of people and not live chat with face but only pictures, only live chat using your voice.I was so desparate and I have this intuition that probably Mike can take me seriously but he is just suddenly gone.I told him I have windblow and I'm a college graduate and I know I can work but I don't know what happened but there was a "pandemic of coronavirus" . Everything changed from there...

It is totally unfair in my part that someone planned to bury me here plainly, it is super ugly tomb, coz it is "Untitled" ... Worst they changed me into a wrong or cheap version of me since 2007...

3:39 am

I still have windblow...

Did Mitch give me that "simple battery"??

Where is Mark, is he here for 17 years? Simply observing me but why??? Not normal...

Hmmm....I feel betrayed...

This song is for the one who inspires me these days...

12:59 noon

John is on over-heat...I wiped him a towel of iced cold water... Later will try to post our video...

1:31 pm

I still have windblow... I wanna leave Cavite.I didn't interfere on whoever they are...

I just don't like anyone here... I feel out of place here... I don't like people who talk bad things about me that they didn't know me at all... I don't like people who are below of my ability to analyze things.

2:06 pm

Yehey!!! Angels got my coffee frother! Wow!!!

2:59 pm

I have windblow...

I just don't like people who interfere so much on me,even on youtube who are controlling me on my "freedom of expression"... I wonder who are they behind that youtube bathroom people...

I still wanna leave Cavite.. Hoping to get a bf and I miss having a bf but I want someone like Pilot Garret or some other men that I like... I feel frustrated...

If Mark is just there, I really wanna leave Cavite.. I love to travel and to meet new friends who can truly pull me up... Not this way... Burying me alive... I FEEL BAD FOR 17 YEARS!

5:35 pm

I still have windblow... Not happy being flatten this way... I feel out of place here in Cavite...

I wanna leave Cavite and I need a bf that I want mutually on me, someone who can pull me up...

Again, I'm a college graduate but someone plan to smash me since 2007... Probably that one is undergraduate...

By looking at the face in a way I can tell the heart...

If I can't see Pilot Garret...

I wanna be in Pampangga if Mark is somewhere nearby.... hello!!! I wanna leave Cavite... I feel small... I wanna tell Mark, I wanna be in Los Angeles...He knows he can...

9:28 pm

Still,have windblow... Fucking tired!!!

I wanna leave Cavite....I feel frustrated.... I have super crush this Pilot Garret...

Hating this windblow sometimes they are so mean to me like a wicked step mom or mean girls...

I feel so frustrated... Thinking of money and job though not my ideal thing to be simply a call center agent but I need money....

I really like Pilot Garret but I can't go up to shine. I really like his nose,eyes and eyebrows.

I'm really douting on Superman Chef Cedrick...It feels like I've met him somewhere or it was just a dream..

I feel fat,old and wrinkled just for here... I feel self-pity...

The 2 fake Uncle's here ( Uncle DD and Uncle Jun ) can't assist me correctly... 1 pack of Anchor Protein Milk here, I need to buy again but I will be out of fundings soon.

The progress of Uncle DD is mainly for their own personal agenda... Our wifi is cut again and again... We can't buy a new TV... The TV here is damaged already... I wanna leave Cavite...

If I can't get Pilot Garret or anyone in youtube... Mark please appear and let's go... I can't stay here for nothing....A lot of Filipino are smashing me unfairly...

I feel bad, I'm not a child, my fear that people will tell on Pilot Garret that I'm a child. I'm not! I just don't have a carrer coz some fucking Filipino's are damaging me or removing me to be liked by the kind of Pilot Garret...

9:55 pm

John humped on my feet, I'm resting on the sofa... He is done,his sperm was on my blanket cloth...

John first experience was on my lower leg, angels...He released himself on me.

John never bite me hard... Sometimes he is playfully biting me but with his bite inhibition awareness... He is biting me but not the real bite.

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[writer59january13]

Future time traveler looks back one century ago

I exhibit health and virility at one hundred and 64 years astride planet earth, whereby spouse, (who remained married to yours truly for about one century – which elapsed in blink of an eye) long since gave up the ghost, which found me receptive to possible mission to date women (strong of body, mind, and spirit with frontier spirit) young enough to be my granddaughter.

Circa December 4th, 2123, or 1212 military time,

yours truly attempted crafting id est feeble rhyme

far from madding crowd, nevertheless yet lovely

bones and flesh quite spry, still considered prime (moost procreative, prodigious, and progressive)

stage, since (case ye didn't know) approximately

eight score orbitz round Earth's sun still noontime

chronologically analogous to protracted lunchtime

whereat the average offspring jetson or (daughter)

Born twenty three years into twenty second century alive

and well (still hashtagged as precocious) with drive

to safely, sidestep, and surmount establishmentarian

archaic, formulaic, and mosaic Judaic/Christian give

wry master of words (me) take poetic license to jive

reasonably rhyming nope heart tickle early misthrive

moost definitely dirty deeds done dirt cheap (trick)

super tramping space cowboy lobbing power-drive

re: frequently innocent prelapsarian double entendre

(Jean Jacques Rousseau) Noble Savage he doth strive

even though hanky panky tinged entire his/her story,

Homo sapiens animal husbandry hastily did wive.

Bajillion years after proto humans experienced woe

countless figurative early Brady bunched bro doggie

dimples encountered necessity to escape cohabitation

(marital covenant alien), yet quasi marital brouhaha

ofttimes witnessed altercation begetting re: thorough

out baby with bath water phenomena, which literal cruel fate heavily peppered past (mine) accounting

lamely explaining Pink Floyd momentary status quo

upended accompanied courtesy lapse of reason no

definitive evidence to substantiate claim, yet I know

without shadowed doubt every friggin forebear (hoe

pining to savor manumission, versus cotton pickin)

back breaking stoop labor think indentured escrow

harking back to days of our lives (mainly bonobo

nasty, short and brutus creatures millenniums ago

unsung simian kindred beings suffering figurative

ruffled horse feathers nsync with bird in hand dodo

which latter species long extinct (as Dutch good eats)

now non sequitur (sea quitter) mine homeboys/girls

comprising Harris eventual clan (of craven lionized

"scapegoats" set genealogical precedent, and grew

some real winners gentiles, who commingled and

intermarried, and united proudly to kvetch as Jew)

eventually acquiring redeeming qualities conveniently

best caricatured as features exhibited by Mister MaGoo

invariably dear reader "fake" anecdote ye will poo poo

as well how storied and fabled coronavirus (COVID-19)

medical technicians reference quaint pandemic setting

figurative global stage brethren and sistern microbes

made webbed, wide world wish for said good ole days

cuz, communique done being crafted about six hours marine hated, armies of beastie boys slain 2123 yahoo

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[bankabio]

INDIAN RAILWAY AND THE BIO TOILET ERA

The Indian railways had announced to introduction of bio toilets in all its passenger coaches.

A revolution in Indian railways

Indian railways achieved a 100% target of bio-toilet installation in trains. There were 2,45,400 bio-toilets installed in Indian railway coaches. By the end of the year 2013, 2774 trains were fitted with bio-toilets.

The bio-toilets help to eliminate the dirt that falls on tracks. The idea to introduce it was to disinfect the human urine and feces. The initiative also started in the times of the coronavirus where maintaining proper hygiene was of utmost importance.

Let us understand what a bio-toilet exactly is.

Understanding bio-toilets

Bio toilets were invented by DRDO and the Indian railways. The anaerobic bacteria are kept in the bio-digester container. This converts human feces into gas and water. Thus, only methane gas and water stay back after decomposing the sewage. The water can be recycled and then used in the toilet. The gases get released into the air. The contaminated water is released on the track after it goes through the process of chlorination.

There are many benefits of bio-toilets. Human feces were dumped on the railway tracks directly. This is used to spread dirt in the environment. It also damaged the rail tracks and is metals. Bio toilets do not let it happen.

Also. earlier at least 15 litres of water used to be spent on the toilet flushing. The vacuum bio-toilets use only half a liter of water. The Indian stations will become cleaner and also be less smelly. This in turn will help to stop the spread of diseases. There will be less mosquitoes and cockroaches. Manual laborers will also not have to do the dirty work.

Bio toilets have indeed changed the Indian railway’s face. This has given a lot of scope to improve track maintenance. The railways also have a lab that maintains these bio-toilets. There is also a team in every railway division. They maintain the bio toilets. The waste is tested in the lab to check the bio-toilet is working fine. Installing bio-toilets is not cheap. It takes around four lakh rupees for installation. This is also part of Indian railway competition with the airlines.

Indian Railways sending on Bio toilets

There is a lot that the government is spending on bio-toilets. This also helps to reuse water usage.

Govt. Bio toilets in Indian railways. This was a part of the Swachh Bharat Mission. This was done along with the Defence Research and Development Organisation or DRDO. The bio-toilets were installed in 79,269 passenger coaches in the years 2021-22. A total of 2, 74,000 liters of human excreta falls every day.

The bio-toilets use an anaerobic bacterial system. This is how the system works. The bio-toilet takes the human waste. This is the input. It then converts it to gas and water. This was monitored well. The railway thus ensures that no amount of human waste falls on the tracks.  Earlier 3,980 tons of human waste used to fall on the tracks.

There were several benefits of introducing bio-toilets. It helped to save rail and fitting corrosion. This technology has brought in a change in the track cleanliness. The first train to install the bio-toilet was the Gwalior-Varanasi Bundelkhand. This was done in the year 2011.

The installation of bio-toilets has been a great success for the railways. However, there were many challenges in this process. The proper functioning of the toilets and its maintenance is a key concern. There are many processes involved and the railways need to address this well. If this is done then railways will be able to create a railway system that is not just efficient but is also environmentally friendly. And it is not only about a clean track. It is a great step by the Indian railways to create a sustainable environment and clean travel for the rail passengers of India.

Post this several passenger trains adopted this.

Conclusion

The Indian railway and the bio-toilet era are indeed sustainable solutions for the railways. We at Bankabio have partnered with India Railways to work towards the initiative. Our toilets use microbial culture power and treat human waste. This converts human waste into environmentally friendly byproducts. This does mark the start of a sustainable technology solution.

Our initiative with the railways helps to improve hygiene. It has a positive environmental impact. It reduces water wastage too. There is also a significant improvement in hygiene because of this initiative by the Indian railways. In turn, this helps to enhance the passenger’s travel experience. Track safety and no risk of corrosion ensure that the rail infrastructure is also well maintained.

Source link [https://theinscribermag.com/indian-railway-and-the-bio-toilet-era/]

[jcmarchi]

Digital Virology: AI’s Expert Eye Identifies Infections - Technology Org

New Post has been published on https://thedigitalinsider.com/digital-virology-ais-expert-eye-identifies-infections-technology-org/

Digital Virology: AI’s Expert Eye Identifies Infections - Technology Org

Microscopy plus machine learning and AI equals a quick, cheap and automated way to detect not only coronavirus, but other emerging pathogens or cellular responses to drugs.

Digital virology, AI in medical research – illustrative rendering. Image credit: Minttu Polso/Aalto University

Before there were vaccines or good ways to diagnose SARS-CoV-2, scientists around the world were scrambling to develop methods for understanding the biology of the virus. While the pandemic opened plenty of scientific opportunities and questions, doors, and borders were also shut almost everywhere.

One of the millions of people who were stuck during early 2020 was computer scientist Christian Guckelsberger. Due to starting a postdoc on AI and creativity in Finland, he instead found himself part of an international biomedical research project to harness machine learning to identify the coronavirus from patient blood samples.

“It was like being thrown into cold water. I’m not a medical person and hadn’t thought about these kinds of things since high school biology,” says Guckelsberger, now an assistant professor of creative technologies at Aalto University and FCAI.

“But this project gave me the feeling of doing something relevant and putting my mind to best use at a critical time.”

Amid pandemic travel restrictions, Guckelsberger’s involvement in the timely, multidisciplinary project allowed him to come to Finland and embark on what he thought would be a two-month project. It ended up lasting an entire year and sparked a renewed fascination for biomedical research and the people doing it.

What Guckelsberger and colleagues developed during that year is a way to automatically classify digital microscopy images of the interactions between antibodies and virus antigens in lab-grown cells. A computer essentially learns to detect if the patient has anti-coronavirus antibodies.

Beyond a diagnosis, the method also gives researchers insight into what features in cells indicate a positive result, what kind of antibody responses are present and allows them to make predictions about the likelihood of a COVID-19 antibody-positive sample from the image alone.

The same sample images classified by a computer were also shown to expert virologists, who rated them as positive or negative for coronavirus antibodies. “Our approach can match the classification level of human experts,” says Guckelsberger, “and it’s much faster. Plus, it can tell us when there are ambiguous results that should be given a closer look by an expert eye.”

The results of the project, recently published in Cell Reports Methods, also show that the method is comparable, and in some ways superior, to widely-used assays like ELISA.

“We used cells, rather than purified virus proteins, as the basis for our assay, which is closer to real physiology,” says lead author Vilja Pietiäinen of the Institute for Molecular Medicine Finland (FIMM) at the University of Helsinki.

“Because everything is completely automated, we have high throughput, but we also get the digital images that can be shown to a virologist or a pathologist, without them having to go to a microscope. The results can even be checked on a mobile device. And we can count the number of infected cells, so we have the quantitative data as well as the visuals.”

During the early days of the pandemic, the research team was able to form quickly thanks to earlier international and local collaborations on virology, imaging and drug response studies, explains Pietiäinen.

“At that point, we needed a high-throughput assay for antibody testing that would indicate if a person had a SARS-CoV-2 infection. Since then, there has been a lot of improvement on SARS-CoV-2 diagnosis, detection, and antibody response,” such as the widely familiar polymerase chain reaction (PCR) test or the antigen test (such as the nose swab) that directly measures the presence of the virus in the body.

The test developed by Pietiäinen, Guckelsberger and colleagues, by contrast, measures antibodies, which tells us how the immune system recognizes the virus and produces different types of antibodies against it.

Machine-learning-based analysis, automated workflow. Image credit: Minttu Polso/Aalto University

“When you only have a few samples, know very little about a disease or might not have access to a high-level biosafety lab, our pipeline can be really valuable,” says Guckelsberger, adding that it can be used anywhere regardless of location, sample preparation equipment or type of microscope. In fact, the pipeline is versatile to test on any germ.

“We designed the test to be used for any emerging pathogen, increasing our readiness for future pandemics,” says Pietiäinen. “Certain components should be optimized for each new virus, but the beauty of the assay is that it can be used for different purposes. It’s already being used to study zoonotic viruses like the Puumala virus.”

Other automated cell-based assays, followed by AI-guided image analysis methods, are being used in the research group to study the drug responses to SARS-CoV-2 as well as to identify drugs that can kill patient-derived cancer cells ex vivo.

Beyond publishing their work and contributing to a better understanding of the pandemic, Guckelsberger and Pietiäinen share a common insight that this project taught them.

“When big questions come up in the world, we as scientists can’t work alone in silos. Experts from different fields, different universities and countries need to come together with a shared aim—in our case, data scientists, clinicians, computer scientists, biochemists,” says Pietiäinen.

“Working in a big team, which is not something we do often in computer science, was fascinating,” echoes Guckelsberger.

“One big challenge was communicating from different perspectives of expertise, for example making sense of what is happening at both ends of the pipeline from wet lab procedures to parameters to data and images. At the same time, this was a fantastic learning experience, and one that I wish to have more of in the future.”

While they employed well-established machine learning for each component of the pipeline, Guckelsberger says making the connection between biologists and computer scientists was one of the real advances. Using technology to resolve biological questions was a big takeaway for Pietiäinen, too.

“Combining microscopy with machine learning, not just for SARS-CoV-2, but to see personalized responses to drugs or to see the cellular phenotypes of rare genetic diseases, is powerful. A picture is worth a thousand words, that is also the case here.”

Source: Aalto University

You can offer your link to a page which is relevant to the topic of this post.

[priyalsoni123]

Stay worry-free with MangoHomz

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[nandini849]

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Imagine you are struggling to research all the options available to you, talk to travel agents and choose accommodations. Tragically, hostels do not provide kitchen offices for cooking. We also cannot ignore the patient’s clinical requirements, such as access to lifts and wheelchairs. Wouldn’t you say that such protests should not be about consideration for the patient and his various controls? Indian authorities have worked to open doors for unknown patients to seek quality and affordable clinical attention in the country. In fact, one could not complain — providing excellent comfort to patients is difficult. The time has come to close the gap between quality clinical facilities and pleasant and affordable housing.

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Mangohomz also provides cheap hotels near aiims New Delhi with all clinical equipments and available 24*7*365. MangoHomz follows the coronavirus insurance and insurance policy.

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Every MangoHomz property invites you to take preventive measures against the new Covid (coronavirus). Our employees are prepared to follow strict SOP (Standard Operating Procedures) rules to prevent the spread of the Covid virus.

[college-girl199328]

Almost three years into the COVID-19 pandemic, testing for the coronavirus is becoming less common and less relevant in Canada, experts say.

The federal government scrapped pre-arrival PCR test requirements for travellers last February and is ending new shipments of rapid antigen tests to provinces and territories.

While supply is not an issue as Ottawa and provincial health authorities have millions of rapid tests in their stockpiles, demand appears to be waning.

“So it may be that a year from now or so, the rapid test may not be necessarily useful,” he told Global News.

"As the virus has mutated over time, the emergence of new variants has also reduced the sensitivity of the antigen tests," said Evans.

Dr. Anna Banerji, an infectious disease specialist at the University of Toronto, said in her opinion, people are using rapid antigen tests less because there is no longer a public health strategy to deal with COVID-19.

Money is another factor to consider, as “these tests are not cheap,” said Evans, so there might be less of an appetite from the government to continue picking up the cost for a tool that was not relied upon to paint a picture of the pandemic in the first place.

Instead, PCR testing done in labs has helped track COVID-19 case numbers and positivity rates in the community, he said.

Ottawa has ordered more than 811 million rapid tests since the beginning of the pandemic, with a price tag of about $5 billion, of which 680 million went to provinces and territories.

So far, the provinces have been providing these tests for free at pharmacies, grocery checkouts, and other locations.

Health Canada said the decision to end shipments at the end of January was made in collaboration with provinces and territories, as the regions have enough supply.

At the peak of the COVID-19 pandemic, rapid antigen tests were an essential go-to for many Canadians.

Cutting back on supply might make it difficult for people who want to continue testing themselves, said Evans.

“It’s going to be really challenging without the rapid test for many people who have relied on them to really figure out if the symptoms they’re having of a respiratory tract infection are due to COVID or just due to some other virus,” he said.

There is also a risk of further spread of COVID since viral shedding can occur up to seven days after COVID-19 symptoms develop, Evans said.

According to Health Canada, there are 90 million rapid tests in the federal inventory, but 6.5 million of those will expire this year and the rest will expire within two years.

Once these tests go beyond their expiration date, accuracy becomes questionable, Evans said.

He said antigen tests can still be safely used one or two months after their expiration, but the reliability is going to diminish the further away one gets from the expiration date on the package.

"There is nothing in the rapid antigen tests that is particularly biologically hazardous, especially if they have never been used," said Evans.

And most pharmacies, clinics, and hospitals are well equipped with biological waste containers, so they should be able to take care of any large lots of expired tests that need disposal.

[newstfionline]

Wednesday, February 1, 2023

Global report highlights link between corruption, violence (AP) Most of the world continues to fail to fight corruption with 95 % of countries having made little to no progress since 2017, a closely watched study by an anti-graft organization found Tuesday. Transparency International’s 2022 Corruption Perceptions Index, which measures the perception of public sector corruption according to experts and businesspeople, also found that governments hampered by corruption lack the capacity to protect the people, while public discontent is more likely to turn into violence. “Corruption has made our world a more dangerous place. As governments have collectively failed to make progress against it, they fuel the current rise in violence and conflict—and endanger people everywhere,” said Delia Ferreira Rubio, the chairperson of Transparency International. “The only way out is for states to do the hard work, rooting out corruption at all levels to ensure governments work for all people, not just an elite few,” she added.

President Biden to end COVID-19 emergencies on May 11 (AP) President Joe Biden informed Congress on Monday that he will end the twin national emergencies for addressing COVID-19 on May 11, as most of the world has returned closer to normalcy nearly three years after they were first declared. The move to end the national emergency and public health emergency declarations would formally restructure the federal coronavirus response to treat the virus as an endemic threat to public health that can be managed through agencies’ normal authorities.

School closures and their toll (USA Today) For all the talk of life getting back to normal, school hasn’t been the same in years. Three years since the coronavirus pandemic shuttered schools across the U.S., students have experienced one disruption after another: a COVID outbreak here, a flood there, an ice storm, hurricane, or tornado over there. Community events, school-related violence, even water system breakdowns have disrupted class. New research published Monday in the journal Nature Human Behaviour concludes that the combination of pandemic-related school closures, the shift to virtual learning where it was even an option and the mental health toll on students set kids back by about a third of a year. The analysis concluded as much based on a review of 42 other studies conducted in 15 countries. Nearly all the world’s student population experienced school closures because of COVID.

The U.S. consumer is starting to freak out. (WSJ) Beginning in 2020, Americans were buoyed by government stimulus checks, hefty savings and cheap credit, but that has started to shift. In recent months, delinquency rates on credit cards and consumer loans approached or hit prepandemic levels. Banks are gearing up for consumers to fall behind on their loans. Retail purchases, spending on services, and sales of cars and homes have dropped; the spate of recent layoffs and high inflation haven’t helped. Consumer spending accounts for roughly 70% of the economy.

Deadly road (Washington Post) Only the water keeps them apart. Russian soldiers—pushed into retreat by a counteroffensive late last year—control the east bank of the mighty Dnieper River. Ukrainians control the west. As Ukraine awaits new tanks from the United States and Europe, and fighting rages over strategic towns in the east, a war of attrition is underway in this southern battleground. The river limits territorial advances, permitting—for now at least—only destruction from a distance. On the route traveling east and north from villages on the Gulf of the Dnieper to the battered but never-occupied city of Nikopol, the width of the river ranges from several miles to fewer than 1,000 feet, putting the Russians close enough to strike with mortars and shells or sniper fire. They hit some villages dozens of times a day. Ukrainian forces are firing back. Roads are still littered with abandoned Russian checkpoints and military equipment. Russian trenches and firing positions are dug into farmers’ fields. Signs warn of mines. At village entrances, Ukrainian troops warn the chances of being shelled are high.

Former Shanghai bookseller’s wife hit with ‘exit ban’ (AP) Chinese police have prevented a woman from returning to her home in Florida in an effort to compel her husband to return to China, she wrote in a letter he made public. The case appears to be the latest example of Chinese authorities placing an “exit ban” on a person’s relatives to pressure them to return. In an appeal to authorities, Fang Xie, 51, wrote that the police have told her that she is “innocent” but that she cannot leave until her husband, a former bookseller who left China after his store was shut down for political reasons, gives himself up. She was barred from boarding a plane in Shanghai last August, her husband Miao Yu said, and hasn’t been able to leave China since. Yu ran one of Shanghai’s best-known independent bookstores until 2018, when local authorities prevented his Jifeng Bookstore from renewing its lease, effectively pushing it out of business. At that time, Yu said, a representative of the public security bureau told him his shop had hosted “too many sensitive scholars” and “sensitive talks.” Exit bans, which critics have likened to hostage-taking, have affected both Chinese citizens and foreigners. The U.S. government includes exit bans as a risk in its travel advisory for people going to China.

U.S. military poised to secure new access to key Philippine bases (Washington Post) The U.S. military is poised to secure expanded access to key bases in the Philippines on the heels of a significant revamp of U.S. force posture in Japan—developments that reflect the allies’ concern with an increasingly fraught security environment in the region and a desire to deepen alliances with the United States, according to U.S. and Philippine officials. The expansion involves access to Philippine military bases, likely including two on the northern island of Luzon—which, analysts said, could give U.S. forces a strategic position from which to mount operations in the event of a conflict in Taiwan or the South China Sea. They will also facilitate cooperation on a range of security concerns, including more rapid responses to natural disasters and climate-related events. While expanded base access is alone not the security linchpin for the region, “it’s a pretty big deal,” said Gregory Poling, director of the Southeast Asia program at the Center for Strategic and International Studies. “This is significant not just in terms of what it means for a Taiwan or South China Sea contingency. This is a signal that the Philippines are all in on modernizing the alliance.”

Baghdad’s Heat and Its Real Estate Boom (NYT) Along the highway in the Dora suburb of Baghdad, the decapitated trunks of dead date palm trees rise up through the sandy soil like fingers from a grave, relics of once-lush groves increasingly being supplanted by a construction boom in Iraq’s expanding capital. Many of Baghdad’s orchards and gardens have been sacrificed to largely unregulated building over the past decade, reducing the green spaces that have traditionally helped keep the capital livable as temperatures increase in what is already one of the hottest cities in the world. Baghdad, with its population of more than seven million, is one of the largest cities in the Arab world. Intersected by the Tigris River, it was once the center of the Islamic world, known for its elaborate gardens. But green space in the capital has contracted in the past two decades, to about 12 percent from more than 28 percent, Ms. Faisal said. Shaded areas in Baghdad are more than five degrees cooler than areas with no plant cover, according to studies. In a city where summer temperatures have reached up to 125 degrees Fahrenheit, dangerously high heat combined with increased air pollution pose particular hazards for the poor, who have no access to air-conditioning. Older people, infants and the sick are particularly vulnerable.

U.S. struggles to face Israeli-Palestinian reality (Washington Post) Secretary of State Antony Blinken is visiting Israel and the occupied Palestinian territories in a period of intense crisis. The deadliest Israeli army raid in years, which claimed at least nine Palestinian lives in the Jenin refugee camp, was followed by an attack on a synagogue in Jerusalem by a Palestinian gunman, who killed seven civilians. In a reflection of how entrenched the cycle of violence is in the Holy Land, it emerged that the assailant’s grandfather had been murdered 25 years ago allegedly by a Jewish supremacist. The ideological bedfellows of those extremists are now in power in Israel. Arriving in Tel Aviv on Monday, the United States’ top diplomat called for “urgent steps to restore calm” between Israelis and Palestinians. But his entreaties may not go very far. Blinken’s visit to Israel and the West Bank comes at a fraught moment. Tensions are mounting between Israelis and Palestinians, after a surge in vigilante attacks carried out by Jewish settlers in the West Bank and raids by Israeli security forces, as well as a spike in attacks carried out by Palestinian militants. There is turmoil, too, within the Israeli political system, as Netanyahu’s new far-right ruling coalition appears bent on overhauling the country’s judiciary, a move critics fear would erode Israeli democracy and pave the way for further Palestinian dispossession. Meanwhile, the enfeebled and unpopular Palestinian Authority, led by Abbas, is losing its grip over the West Bank, where many Palestinians now view the entity as an accomplice in the decades-old Israeli military occupation.

Pope’s Africa trip spotlights conflict, and church’s future (AP) Pope Francis is opening a six-day visit to Congo and South Sudan on Tuesday, aiming to bring a message of peace to two countries riven by poverty, conflict and what Francis has called a lingering “colonialist mentality” that still considers Africa ripe for exploitation. Aid groups are hoping Francis’ trip will shine a spotlight on two of the world’s forgotten conflicts and rekindle international attention on some of Africa’s worst humanitarian crises, amid donor fatigue and new aid priorities in Ukraine. But Francis’ trip will also bring him face-to-face with the future of the Catholic Church: Africa is one of the only places in the world where the Catholic flock is growing, in terms of practicing faithful as well as fresh vocations to the priesthood and religious life. That makes his trip, his fifth to the African continent in his 10-year pontificate, all the more important as Francis seeks to make his mark on reshaping the church as a “field hospital for wounded souls” where all are welcome and poor people have a special pride of place.

Nigeria’s push for redesigned currency creates cash shortage (AP) Nigeria’s push to replace its paper money with newly designed currency notes has created a shortage of cash, leaving people unable to buy what they need and forcing businesses to close across the West African nation, experts and business groups said. The Central Bank of Nigeria says the redesigned denominations of 200 (43 U.S. cents), 500 ($1.08) and 1,000 naira ($2.17) notes and new limits on large cash withdrawals would help curb money laundering and make digital payments the norm in Africa’s biggest economy. But the process to replace the old currency notes is “rushed,” and commercial banks don’t have enough new cash to give to customers, pushing demand higher than supply, said Ayokunle Olubunmi with Nigeria’s main ratings agency, Agusto and Co. The government is pushing for a cashless economy that is more inclusive and says the changes will drive economic growth. Critics are skeptical, pointing to decades of chronic corruption in which government officials are known to loot public funds and create more hardship for the many struggling with poverty.

[jadekinsjackson]

Jade Talks Cheap Flights #10 – Flights Back to Australia Hi, with the recent drama of my sister's flight to Australia being cancelled, there was a lot of people caught up overseas without clear instructions from the airline and with uncertainty how to get home, so todays episode is dedicated to all the best flight options, for Australians to get back home to Australia, this week, before all the airlines ground their fleet due to coronavirus.

[janetang1]

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[damianogender]

god KNEW if i were an adult who didn't have to answer her parents that i would be travelling the world right now and would see ~every beautiful place~ without other people crowding them!!!! in peace and silence!!!!! which would quite possibly cure my depression and i'd be too powerful then