#cc: shao

[valyrra]

♡ General ♡

[valyrra]

That was way too fun thank you so much for tagging!!!!?!

No pressure tagging: @esolean @localravenclaw @shanaraharlyah @gil-galado @nadilu @queen-of-stoneharts @sinimake @matchbet-allofthetime @josukesbonnet @jenkaixcx @joliackermann @temporaryusername2015 and everyone who wanna join

Tagged by: @thesingularityseries

Tagging (if you want 💅): @malicedragoness @theelderhazelnut @valyrra @luna-di-fuoco

[inspofromancientworld]

End of the Han Dynasty

On the 10th of December 220 CE, Emperor Xian of Han was forced to abdicate by Cao Pi, which ended the rule of the Han Dynasty over China. This act was the culmination of 31 years of Emperor Xian of Han's reign over China, from 28th September 189.

By Gary Lee Todd - http://www.garyleetodd.com/chinese-museums-online/luoyang-6-horse-chariot-burial-tomb-museum/, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=4918196

In 184, during Emperor Ling of Han's reign, the writing was on the wall for chaos upon his death given the corruption of his reign. In 188, one of his advisors, Liu Yan, claimed that the cause of agrarian revolts that were happening, such as the Yellow Turban Rebellion, which was a peasant uprising in 184 CE, so he suggested that Inspectors should become Governors that had more authority, including the ability to command the armed forces and levy taxes. Liu Yan became one of the Governors, which was a continuation of the corruption and heavy taxation that was a hallmark of Emperor Ling's reign.

As Emperor Ling became ill in 189, he had two sons who'd survived to adulthood, Liu Bian and Liu Xie, who had been raised by foster parents to attempt to prevent the continuation of his sons not reaching adulthood. One was born to Empress He Lingsi, the other born to Consort Wang Linghuai. He refused to make a decision between his sons. Because of this, there was a power struggle when he died between supporters of his sons. One supporter, a eunuch, meant to kill Empress He's father, a general, but when he found out, he proclaimed his 13 year old grandson emperor, making his daughter regent for him. Liu Bian became known as Emperor Shao.

As a result of the assassination attempt, General He plotted to exterminate the Ten Attendants, eunuchs who enjoyed great power under Emperor Ling. His daughter, Empress Dowager He, disagreed with this action, which led General He to order a warlord to march on the capital at Luouang to make her change her mind. The eunuchs found out and assassinated General He. The companion of General He summoned, Yuan Shao, went on a rampage and tried to kill all the palace eunuch, regardless of whether they were involved in the Ten Attendants or not. Those that survived kidnapped Emperor Shao and his brother.

By Unknown author - Taken from Gongjin's Campaign Memorials: a Three Kingdoms WikiZengxiang quantu Sanguoyanyi, Public Domain, https://commons.wikimedia.org/w/index.php?curid=37570947

Dong Zhuo, the warlord General He charged with infiltrating the capital found the boys (13 and 8 at the time). The emperor was anxious while the prince was calm and ordered Dong Zhuo to return them to the palace. Dong Zhuo took the opportunity to take over and he poisoned the emperor and replaced him with his brother, who became Emperor Xian. Dong Zhuo set himself up as 'Chancellor of State' and then granted himself the 'privilege of attending court without needing to disarm himself or remove his shoes'.

By Unknown author - Zengxiang quantu SanguoyanyiTaken from http://threekingdoms.wikia.com/wiki/File:Dong_Zhuo_-_Qing_ZQ-SGYY.jpg, Public Domain, https://commons.wikimedia.org/w/index.php?curid=37570496

Spring of 190 saw a coalition rising up against Dong Zhuo, charging him with kidnapping Emperor Xian and usurping the throne. Yuan Shao was selected leader of the coalition, though the coalition was rather disorganized and afraid to actually confront Dong Zhuo, so the position of leader was basically in-name-only. Dong Zhuo, however, was spooked and moved the capital to Chang'an, then a month later, forced Emperor Xian and the rest of the court there and for the old capital to be burnt down.

In 191, the coalition resisting Dong Zhuo tried to put Liu Yu, who was a member of the royal family's clan, on the throne, but he declined because he was loyal to Emperor Xian. With the continued disorganization of the coalition, Sun Jian, a general under Yuan Shu attacked Dong Zhuo near Luoyang and scored several victories, forcing him to retreat back to Chang'an. The coalition didn't push their advantage and eventually disbanded. The rebellion did give several members the idea to rule over their own territory as kings.

The uprising caused Dong Zhuo to become crueler in his unofficial regency. Dissent continued to simmer, though, even including Dong Zhuo's foster son Lü Bu, who was having an affair with one of Dong Zhuo's maids and held a grudge against Dong Zhuo over an episode when attempted to murder him. Lü Bu and Wang Yun, the interior minister, led the assassination of Dong Zhuo and the rest of his clan in 192.

Wang Yun was set up as regent because he was considered level headed, but power went to his head and he failed to keep on the good side of those who helped him get that power as well as not granting amnesty to those who survived that were part of Dong Zhuo's reign, leading them to become nervous that they might be massacred. This fear caused them to rise up and revolt against Wang Yun and they eventually took control of Chang'an and executed Wang Yun.

The remainder of Dong Zhuo's army were very self-serving, so various warlords rose up and took control of various provinces, though they paid lip service to Emperor Xian as they do. In 195, Emerpor Xian was allowed to go back to the old capital of Luoyang, but then his captor-regents regretted that decision. They were unable to recapture him. The devastation wrought by Dong Zhuo, though, left those who were left at Luoyang starved to death. A tug of war between high ranking officials of the territory near the capital as to whether they would accept the emperor or not.

By Wang Qi (1529 - 1612) - A copy of w:Sancai Tuhui, Public Domain, https://commons.wikimedia.org/w/index.php?curid=10217506

Cao Cao, a warlord and poet, took advantage of this indecision and brought Emperor Xian to his territory in 196. He was a minor warlord at the time and in 196, he led a campaign of both conflict and diplomacy to gain control over Emperor Xian and used the authority of the emperor to move the capital to Xu within his territory. He was respectful to Emperor Xian, but ruled for the emperor.

Because of the preceding chaos, there was a severe lack of food and money, so Cao Cao sent soldiers to farm under- or undeveloped land. The harvests were sold between the military and the people. Because this was successful around Xu, it was adopted further out. Cao Cao sought to reunite the various provinces of China at the time, though it was complicated by things like an affair Cao Cao had with a widowed aunt of one warlord.

In 197, Yuan Shu, a warlord who opposed Cao Cao, declared himself 'Son of Heaven', basically emperor, an act of treason against the Han dynasty, which caused other warlords to attack him and those who had alliances with him to break them. Yuan Shu tried to flee to join Yuan Shao, but his way was blocked and he ended up dying of illness in 199.

In a bid to gain control of Emperor Xian in 198, Yuan Shao tried to get Cao Cao to move the capital to Juancheng, closer to his territory, but Cao Cao refused. Cao Cao also joined forces with another warlord to attack Lü Bu. He captured Lü Bu and executed him, which gained Cao Cao more territory.

By Nederlandse Leeuw, Qiushufang - Own work, based on excerpts from File:Topographical 3K gif.gif, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=87411546

Yuan Shao defeated another warlord in 199 at the Battle of Yijin and the defeated warlord committed suicide by fire. This expanded the Han dynasty nominally, but the territory was under Yuan Shao. Yuan Shao used this victory to turn against Cao Cao directly. By 205, though, Cao Cao had conquered all the Yuan held territories. By 207, there were three kingdoms under the empire of China, Cao Cao's, Liu Biao's, and Sun Quan's.

The next 13 years were a continuous push for each of these territories to expand their holdings, including an alliance between Liu Biao and Sun Quan against Cao Cao, which was eventually broken in 219 over seizing of food supplies and building resentments.

By Yan Li-pen - http://hi.baidu.com/%CB%CE%BE%FC%D2%C5%C3%F1/album/%D1%D6%C1%A2%B1%BE%20%C0%FA%B4%FA%B5%DB%CD%F5%CD%BC%BE%ED, Public Domain, https://commons.wikimedia.org/w/index.php?curid=1872130

In 220, Cao Cao died and his son Cao Pi inherited his title, taking it before Emperor Xian could officially grant it. That winter, Emperor Xian sent his Imperial Seal, the symbol of his power, to Cao Pi, and issued an edict that he was abdicating. Cao Pi tried to decline, but he eventually accepted, officially ending the Han Dynasty. Former Emperor Xian was granted a ducal title.

In 221, Liu Bei declared himself emperor and Sun Quan declared himself separately in charge of the state of Wu, more commonly known as Eastern Wu, in 222, then emperor of Wu in 229, thus officially starting the Three Kingdoms era.

[odditycircus-2002]

Had a random headcannon pop in my head while reI watching some episodes of The Nanny. Mostly that I one hundred percent see Medusa Reader and Shao or Reiko having a similar dynamic to Niles and CC, mainly where Niles always insults CC and CC tries to get him back, but Niles always comes out on top. In this case Medusa reader is Niles and they had this dynamic long before she was turned into her current snakey state. I especially like the idea of her calling Shao and Reiko dogs because of the "war dogs" saying. So I just imagine when Shao calls Raiden scrawny if Medusa reader had been there she would have made a comment like "Oh don't be jealous, you can still lose weight to fit back into your debutante dress." Or if she was with some people getting a tour of a really nice room in the palace and the person goes "How do you manage to keep this room so beautiful?" she basically just replies "because they have a childproof lock on the door so Shao can't get into it." Stuff like that.

First off, always a pleasure to hear from you again. Heads up, I don’t watch that show so I don’t understand everything. That being said, that basically fits well with Medusa!Reader and Shao😆 In my head, they’ve always had beef no matter the timeline. To Y/N, Shao is a brute who acts before he thinks. Although, I’d imagine insulting Y/N is a bit hard to do when she had to bandage him up countless times during his early career.

General Shao: You wouldn’t last a day as an Outworld soldier!

Y/N: You’re talking to the same person who once has their hands buried elbow deep within you trying to stuff your guts back in.

[sulzuulsul]

ye suhua / shao siming - ps I did end up giving her a dog and yes ik the body isn’t the best match, but with no mods/cc it was the best I could do🙃😅🙃

[sbgridconsortium]

A small molecule that clogs up ribosome machinery

This publication highlight is part of the SBGrid/Meharry Medical College Communities Project, focused on science education and demonstrating how structural biology and preclinical science connect to medicine.

Ribosomes are essential molecular machines in the cell. They create proteins through the translation of RNA into an amino acid sequence. This process of translation is an important topic of study for molecular and structural biologists because of its vital role in maintaining life and the proteome. The production of the full proteome is essential for life and any variance or interference in the process could lead to drastic consequences. Because of this, the study of how small molecules and drugs interact and influence the ribosome is an ever-present question for structural biologists and medicinal chemists. In Nature Chemical Biology, SBGrid member Dr. Susan Shao from Harvard University, shows the unique effect that a small molecule, SRI-41315, has on the ribosome. 

Ribosomes are made of many different protein and RNA units. The process of creating amino acid chains from an RNA transcript is highly dynamic and requires the timely introduction and removal of a library of participating molecules in the translation symphony. One of these molecular players in translation is eukaryotic translation termination factor 1, eRF1. This protein binds to the ribosome subunits and aids in the termination or conclusion of the translation process. eRF1 helps the ribosome read the translation instruction, the mRNA, and helps the ribosome know when to stop and remove the finished amino acid chain. The small molecule SRI-41315 has been known to degrade eRF1, but the mechanism for this degradation was unknown until Dr. Susan Shao and colleagues proposed the following using cryo-EM and molecular assays: 

Pictured above is small molecule SRI-41315 (gray) interaction with eRF1 (green) and RNA (orange) in the ribosomal complex. PDB:8SCB. CC BY SBGRID

Using electron microscopy at cryogenic temperatures, a technique known as cryo-EM, Dr. Shao was able to create a model of eRF1 in complex with a ribosome with SRI-41315 bound. In this model, SRI-41315 was shown to act as a glue in the machine. This small molecule locked eRF1 into a specific configuration, limiting the dynamic process of translation. By gumming up the ribosomal machine, SRI-41315 increased eRF1 degradation and affected the machine's ability to accurately produce functional proteins. The ability of this small molecule to indirectly slow down and effect the efficiency of translation is a very compelling observation and provides evidence for the wide array of functions small molecules can have in living systems.

To learn more about the clog in the ribosomal machine, continue reading at Nature Chemical Biology. 

Vida Storm Robertson, Fisk University

Vida Storm Robertson is a Masters Student in Chemistry at Fisk University working in both solid-state and solution based structural determination techniques. He plans on starting a PhD program in biophysics in the fall of 2024.  

[wikiuntamed]

On this day in Wikipedia: Sunday, 7th January

Welcome, chào mừng, vítejte, καλωσόρισμα (kalosórisma) 🤗 What does @Wikipedia say about 7th January through the years 🏛️📜🗓️?

7th January 2023 🗓️ : Event - January 2023 Speaker of the United States House of Representatives election The longest U.S. House of Representatives speaker election since the December 1859 – February 1860 U.S. speaker election concludes and Kevin McCarthy is elected 55th Speaker of the United States House of Representatives. "At the opening of the 118th United States Congress, the members-elect of the House of Representatives elected in the 2022 midterms held an election for its speaker, marking the 128th speaker election since the office was created in 1789. It began on January 3, 2023, and concluded in the early..."

7th January 2018 🗓️ : Death - Jim Anderton Jim Anderton, Former New Zealand Deputy Prime Minister (b. 1938) "James Patrick Anderton (born Byrne; 21 January 1938 – 7 January 2018) was a New Zealand politician who led a succession of left-wing parties after leaving the Labour Party in 1989. Anderton's political career began when he was elected to the Manukau City Council in 1965. After serving for five..."

Image licensed under CC BY-SA 2.0? by

Jim_Anderton_talks_with_supporters.jpg: Ben Ross

derivative work: Schwede66

7th January 2014 🗓️ : Death - Run Run Shaw Run Run Shaw, Chinese-Hong Kong businessman and philanthropist, founded Shaw Brothers Studio and TVB (b. 1907) "Sir Run Run Shaw (19 November 1907 – 7 January 2014), also known as Shao Yifu and Siu Yat-fu, was a Hong Kong businessman, filmmaker, and philanthropist. He was one of the foremost influential movie moguls in the East Asian and Hong Kong entertainment industry. He founded the Shaw Brothers Studio,..."

Image by Uncredited

7th January 1974 🗓️ : Birth - Alenka Bikar Alenka Bikar, Slovenian sprinter and politician "Alenka Bikar (born 7 January 1974) is a retired female sprinter from Slovenia, born in Ljubljana. She specialised in the 200 metres, competing in three Olympic games from 1996 to 2004. She was also named Slovenian Sportswoman of the Year in 2001. Bikar won the gold medal in the 200 m in the..."

Image licensed under CC BY-SA 2.0? by https://www.flickr.com/photos/thepaperboy/ Ian @ ThePaperboy.com

7th January 1923 🗓️ : Birth - Vaklush Tolev Vaklush Tolev, Bulgarian theologian, educator, public figure and lecturer (d. 2013) "Vaklush Tolev (Vaklush Tolev Zapryanov, Bulgarian: Ваклуш Толев Запрянов), also known as Vaklush, The Teacher of Wisdom, was a theologian by education, a public figure, university lecturer, and author of a multitude of works which are religious, philosophical, cultural and historical in terms of..."

7th January 1815 🗓️ : Birth - E. Louisa Mather Elizabeth Louisa Foster Mather, American writer (d.1882) "Elizabeth Louisa Mather (née Foster; January 7, 1815 – February 5, 1882) was an American writer. She wrote essays, stories and poems for 40 years on religious subjects, capital punishment, and woman's suffrage...."

Image by F. C. Pierce

7th January 🗓️ : Holiday - Christian Feast Day: Raymond of Penyafort "Raymond of Penyafort (Catalan: Sant Ramon de Penyafort, IPA: [ˈsan rəˈmon də ˌpɛɲəˈfɔɾ]; c. 1175 – 6 January 1275) was a Catalan Dominican friar in the 13th century, who compiled the Decretals of Gregory IX, a collection of canonical laws that remained a major part of Church law until the 1917 Code..."

Image by Tommaso Dolabella

[flourishfox]

Shaoran Li x Sakura Kinomoto

[virtuallyinsane-dark]

"Under The Stories" by Xiwen Zhu, Panpan Shao / CC BY-NC-ND 4.0

[architectnews]

Shenzhen Building News, Guangdong Architecture

Shenzhen Architecture News, Guangdong Building Designs, Architects, Chinese Property Photos

Shenzhen Building News

Contemporary Chinese Architecture Developments: Guangdong Province Built Environment Updates

post updated 6 Sep 2020

Shenzhen Architecture News

Shenzhen Architectural News, chronological:

Shenzhen Architecture Designs – chronological list

28 Aug 2020 Prince Plaza, Shekou District Design: OMA / David Gianotten photograph © Seth Powers, courtesy of OMA Morden Wharf Greenwich Peninsula Prince Plaza was commissioned by CMSK (China Merchants Shekou Holdings). The mixed-use podium tower is located at Shekou’s most prominent view corridor linking the Nanshan mountains and the Shenzhen Bay.

26 Aug 2020 SUSTech School of Medicine & Hospital – Tender

25 Aug 2020 Shenzhen Fuwai Hospital Phase III

7 August 2020 SHUIBEI International Centre Building, Luohu Architects: Aedas photo : CreatAR Images SHUIBEI International Centre Building Design Shaping the city’s skyline with contemporary urban renewal developments, he states that, “Urban regeneration is not simply replacing old and weathered buildings with new ones, but rather building a new relationship and a deeper connection between the city and its people through these new developments. This connection requires more than just space as it also integrates everyday organic synergy from the community.”

13 May 2020 China Resources’ MixC Market Hall Architects: 10 DESIGN image courtesy of architects office China Resources’ MixC Market Hall Sungang MixC Market Hall, China Resources’ new mixed-use development is under construction in Shenzhen, China with anticipated completion by Q3 2022. Located on a former industrial zone, this retail-gastronomy destination will provide an immersive gastronomic experience under one roof.

18 Feb 2020 C Future City Experience Center, Shangsha Architects: CCD/ Cheng Chung Design (HK) image courtesy of architects office C Future City Experience Center Shangsha used to be a coastal fishing village, which has developed along with the renewal of the city, while now it is witnessing the rising of C Future City. Through reflecting on the values that rooted in the village, CCD finally decided to take “marks of the fishing village” as the starting point for the design.

10 Feb 2020 Qianhai Talents’ Apartments Design: Foster + Partners image © Foster + Partners Qianhai Talents’ Apartments Shenzhen An innovative residential project in Shenzhen aimed specifically at the rental market. The project is envisaged as a building exclusively for ‘talents’ – professionals who would have an intensive work-centred lifestyle.

Shenzhen Building News 2019

16 Dec 2019 Ensue Luxury Restaurant, Futian District Design: Chris Shao Studio LLC photographer : Common Studio: Lit Ma & Kelly Puleio Studio Ensue Luxury Restaurant in Shenzhen Simple and natural elements engage the guest with a new experience of fine dining, by way of redefining a luxurious and opulent experience with a more naturalistic aesthetic that still embodies refined detail.

14 Dec 2019 Huitong Hybrid Tower Design: Jaeger Kahlen Partners Architects photographer : 叶文锐 Wenrui Ye Huitong Hybrid Tower in Shenzhen A novel idea in skyscraper design: part world-class office space and part high-tech car park. By efficiently and seamlessly integrating parking spaces into the design, JKP increased buildable area under zoning regulations and maximized the value of the project to both the users and the city.

8 Nov 2019 Konka Tower Architects: Mecanoo image courtesy of architects Konka Tower The city is searching for new models for urban and architectural innovation to replace the traditional model of large-scale indoor shopping malls and focus on flexible development.

21 Sep 2019 MORPH, Nanshan District Architects: Various Associates photograph : Shao Feng MORPH, Nanshan District Occupying a corner of a building, MORPH is a mixed-use space with a total construction area of 1,000 sqm. With an urban park and Houhai business circle nearby, it’s a rare tranquil place amidst the hustle and bustle of the downtown area.

11 Sep 2019 Typhoon-proof Shenzhen East Coast

16 July 2019 Futian Civic Cultural Centre Building

5 July 2019 Folding Residence, Longgang District

3 July 2019 Sheraton Shenzhen Nanshan, Xili Hotel

18 June 2019 The King’s School Shenzhen International, Nanshan Architects: Walters & Cohen image from architects The King’s School Shenzhen International Building Located in Nanshan, China, the school offers pupils aged 2 to 18 a combined Chinese and British curriculum, with a greater emphasis on the latter as pupils progress through the school.

8 Jan 2019 Qianhai Data Centre Architects: Mecanoo image from architects Qianhai Data Centre Shenzhen Building Infrastructural facilities are the functional heart of modern cities. Although usually concealed, these buildings are essential for urban daily life. When visible, they have the capacity of being a symbol of the technological achievements of our time.

More contemporary Shenzhen Building News on e-architect soon

Southern Guangdong Province Architecture Updates 2018

7 Aug 2018 Shenzhen Energy Company Office Skyscraper Architects: BIG-Bjarke Ingels Group image : Chao Zhang Shenzhen Energy Company Office Skyscraper Building The new home for Shenzhen Energy Company looks different because it performs differently: the building skin is developed to maximize the sustainable performance and workplace comfort in the local subtropical climate of China’s tech and innovation hub.

8 Aug 2018 Sunac – Smart Valley Shenzhen Architects: BLVD International image courtesy of architects Sunac – Smart Valley Shenzhen Building The overall design intentionally breaks people’s stereotyped perception of the tediousness of science and technology, integrates the ecological concept into the geometry and modernity of technology, and transforms the lines of science and technology into the surface treatment in the real space.

11 Aug 2018 Shenzhen Bay Square Waterfront Design: MAD Architects image courtesy of architects Shenzhen Bay Square Waterfront by MAD Architects MAD Architects, led by Ma Yansong, win two international competitions – the winning masterplan (36 hectares), and architectural design (15 hectares), will see an ambitious urban development project bring a vibrant cultural complex to the area that connects Shenzhen city to the waterfront, surrounding ecological corridor, and nearby mountain ranges – creating a harmony between humans and nature.

26 Jul 2018 Forest and Sports Park in Guang Ming Architects: LOLA, TALLER and L+CC picture courtesy of architects office Forest and Sports Park in Guang Ming LOLA, TALLER and L+CC won the international competition for a 600 hectare forest and sports park in Guang Ming, Shenzhen, China. The other competitors were JCFO, SWA and TCL.

10 Jul 2018 Qianhai SZ-HK Fund Town Architects: Leigh & Orange photo : Leigh & Orange Qianhai SZ-HK Fund Town Building The project is located at the Qianhai district in Shenzhen China. Known as “Qianhai SZ-HK Fund Town”, it consisted of a variety of low-rise building typologies designed to suit different office and commercial uses. These include midrise row-offices, corporate villas, stand-alone retail pavilions and a basement retail street.

7 Jul 2018 Longgang Chuangtou Tower Architects: URBANUS Architecture & Design photograph : SHU He Longgang Chuangtou Tower in Shenzhen Building The architecture is a container that captures light, just like how a musical instrument captures music. Light needs a structure that can show it. VC&PE has an open spatial structure, is interspersed with deconstructed blocks, and has a rhythmical unit form, which gives light the best expression carrier.

4 Jul 2018 Pingshan Performing Arts Center Design: OPEN Architecture photograph : Zhang Chao Pingshan Performing Arts Center Building OPEN’s Pingshan Performing Arts Center in Shenzhen has moved another step closer to its expected completion this year. With the building envelope now fully installed, the focus has shifted to the interior fit out and landscape construction phase.

5 Jun 2018 Space in Mutation, Berlin, Germany Curated by Doreen Heng Liu, NODE Architecture & Urbanism, Shenzhen Collage Shenzhen © NODE Architecture & Urbanism Space in Mutation Opening: Friday, 29 June 2018, 6.30pm Exhibition: 30 June – 15 August 2018 Location: Aedes Architecture Forum, Christinenstr. 18-19, 10119 Berlin Opening Hours: Tuesday-Friday 11am-6.30pm, Sunday-Monday 1-5pm Special Opening Hours: Saturday, 30 June 2018, 1-5pm

Symposium: Friday, 29 June 2018, 4pm Location: ANCB The Aedes Metropolitan Laboratory, Christinenstr. 18-19, 10119 Berlin

9 May 2018 DJI’s new HQ, Shenzhen, China Architects: Foster + Partners image : Foster + Partners DJI HQ Building News Foster + Partners today unveiled their vision for the new headquarters for DJI, the world leading robotics company, currently under construction in Shenzhen.

2 May 2018 Shekou Sea World Culture and Arts Center Architects: Maki and Associates photo © Shu He Shekou Sea World Culture and Arts Center The building highlights openness and connectivity, so that people, space and nature can have quiet dialogues. The lighting coincides with them to hide among buildings and landscapes to give off soundless beauty.

Prince Bay Development Design：John Portman & Associates image © John Portman & Associates Prince Bay Shenzhen Development News John Portman & Associates is happy to announce a first-place finish in the international design competition held by Shenzhen Prince Bay Shang Long Real Estate Co., LTD for the architectural and engineering design of Prince Bay lot DY02-06A in Shenzhen, China.

23 Apr 2018 ROARINGWILD · UNIWALK Interior Interior Design: Kingson Liang | DOMANI photograph © Shaon Liu Store Interior Shenzhen City China’s native original Tide brand ROARINGWILD roaring in the 7th year, the brand rooted in Shenzhen which opened the first entity stores. Space designed by DOMANI, consistent of the fierce strokes presented shake the soul of the visual impact and sensory illusion.

20 Apr 2018 Sky Club House Architects: DOMANI photograph : Shaon Sky Club House Shenzhen City

More Shenzhen Architecture Design News online soon

Shenzhen Architecture News

Location: Shenzhen, China

Chinese Buildings

Hong Kong Walking Tours

Hong Kong Skyscrapers

Shenzhen Museum of Contemporary Art & Planning

Shenzhen 4 in 1 Towers

Ensue Restaurant

Chinese Buildings

Comments / photos for the Shenzhen Building Design News page welcome

Website: Architecture

The post Shenzhen Building News, Guangdong Architecture appeared first on e-architect.

[valyrra]

More Shao whoops💌

[blsnaps]

[ENG SUB] HIStory 3: Trapped couple - Tang Yi and Shao Fei one day ‘public date’ in Hong Kong

now with eng subtitles, click on CC button on video. Jake takes care of the allowance they got for their ‘date’ and Chris takes care of Jake ♡

If this video reaches 200k views soon, NewShowBiz will give us/them a reward. 

[kurogabae]

Wait, is there a pronounciation guide for tsubasa names? Cuz like i have my own ways of pronouncing it while reading but ive no idea if im right lol

Japanese pronunciation is pretty simple, especially compared to English (which is my native tongue and haha a hot mess). We’ll go through the family.

One rule is that each syllable in Japanese is pronounced with the same amount of emphasis to it, unlike a lot of the Germanic and Romantic languages (there might be exceptions but this is very beginner stuff). Each vowel also always sounds the same - “a” = “ah” (like ah-ha) “e” = “eh” (like meh) “i” = “ee” (like in eel) “o” = “oh” (like in oval) and “u” = “oo” (like in coo).

Sakura - the CCS English dub of the 90s and many Americans that I know pronounce this “SAH-core-uh” and they are wrong - you would say her name “sah-koo-rah”.

Syaoran is a little different because his name is based in Chinese. He also has a similar problem to Fai where there are many spellings. The correct way, though is “shao-rah-n”. The “ao” make a sound similar to “ow” but not exactly. I would describe it as rounder?

Fai/Fye/Fay/whatever. The katakana used to spell his name, which is meant to be foreign spells it Fai. This is one of the few times vowel sounds will “change”. If you have “a” + “i” you get a sound like “eye” as in eyeball. So you would say “feye”. 

Kurogane has the longest name with the most syllables and it’s be “officially” butchered. “KER-oh-guh-ney” is not the correct way to say it. “koo-roh-gah-neh” is. 

Mokona usually only suffers from people putting incorrect emphasis since her name is pretty simple. “moh-koh-nah” all nice and easy.

If I’m wrong about any of the rules for Japanese pronunciation please tell me, I am by no means a fluent speaker, I just took the time to do my best to learn how to say the words I saw.

[reifromrfa]

Top Ten Husbandos~

Rules: Put your ten fictional or real husbandos and tag people!

Thank you for tagging me, @posts-from-rainy-days 😄

Not in any order haha I love them all 😄❤

1. Vanderwood from Mystic Messenger

2. Jumin Han from Mystic Messenger

3. Zen from Mystic Messenger

4. Saeran from Mystic Messenger

5. Saeyoung from Mystic Messenger

6. Leon S. Kennedy from Resident Evil

7. Tamahome from Fushigi Yuugi

8. Li Shao Ran from CCS (childhood crush hng 😭)

9. Damon Salvatore from Vampire Diaries

10. Vincent Keller from Beauty and the Beast

Tagging @rossyele @kilofox @monotonemanday @lonesandkorn @rainydayswriter @aehruh @digitalscratch-arting @chaoticstarblossoms @mysticmikalla @darth-zoja @phoenixsavant @thedementeddragon @savvylittlewriting @rowan-catsandcoffee @tahleec @mahousekai @yukina-chi

[phdsobko]

Lecture: "Cell biologist’s perspective. Frontiers in Development of HDAC Degraders. by Alex Sobko, PhD. May 2022. from Alexander Sobko on Vimeo.

Lecture: "Cell biologist’s perspective. Frontiers in Development of HDAC Degraders. by Alex Sobko, PhD. May 2022.

© 2022, Alex Sobko, PhD © 2022, Record, edit, post at social media by Alex Sobko, PhD, 8762728 IL (ישראל)

References and Textbooks:

Epigenetics, Cancer, Aging

Ageless Quest: One Scientist's Search for the Genes That Prolong Youth. Leonard Guarente. CSHL Press, 2002.

Lifespan: Why We Age―and Why We Don't Have To. David A. Sinclair PhD, Matthew D. LaPlante. 2019.

Lewin’s Genes XII. Krebs, Jocelyn E., Goldstein, Elliott S., Kilpatrick, Stephen T. Jones & Bartlett Learning, 2018.

Epigenetics, Second Edition, Edited by C. David Allis et al, CSHL Press. © 2015. Chapter 4. Writers and Readers of Histone Acetylation: Structure, Mechanism, and Inhibition. Ronen Marmorstein, Ming-Ming Zhou. Chapter 5. Erasers of Histone Acetylation: The Histone Deacetylase Enzymes. Edward Seto, Minoru Yoshida. Chapter 34. Epigenetic Determinants of Cancer. Stephen B. Baylin, Peter A. Jones. Chapter 35. Histone Modifications and Cancer. James E. Audia Robert M. Campbell. Epigenetics and Cancer.

Feinberg AP, Koldobskiy MA, Göndör A. Epigenetic modulators, modifiers and mediators in cancer aetiology and progression. Nat Rev Genet. 2016 May;17(5):284-99.

Zhao S, Allis CD, Wang GG. The language of chromatin modification in human cancers. Nat Rev Cancer. 2021 Jul;21(7):413-430.

Cynthia J. Kenyon. The genetics of ageing. Nature, 2010, 464, 504. Cell 166, 2016.

Payel Sen, Parisha P. Shah, Raffaella Nativio, and Shelley L. Berger. Epigenetic Mechanisms of Longevity and Aging. Cell 2016, 166, 822-839.

Molecular degraders

Alessio Ciulli and Nicole Trainor. A beginner’s guide to PROTACs and targeted protein degradation. October 2021 © The Authors. Portland Press Limited under the Creative Commons Attribution License 4.0 (CC BY-NC-ND).

Stuart L. Schreiber. The Rise of Molecular Glues. Cell 2021, 184. Rati Verma, Dane Mohl, and Raymond J. Deshaies. Harnessing the Power of Proteolysis for Targeted Protein Inactivation. Molecular Cell, 2020, 77.

Wu, T., Yoon, H., Xiong, Y. et al. Targeted protein degradation as a powerful research tool in basic biology and drug target discovery. Nat Struct Mol Biol 27, 605–614 (2020).

HDAC Inhibitors, HDAC-degraders

EPIGENETIC THERAPY WITH HISTONE DEACETYLASE INHIBITORS: IMPLICATIONS FOR CANCER TREATMENT. Soares, C. P., Santos, J. L. D., Sousa, Â., eds. (2021). Lausanne: Frontiers Media SA. (Front Cell Dev Biol).

Jia Tong Loh, I-hsin Su. Post-translational modification-regulated leukocyte adhesion and migration. Oncotarget, 2016, 7(24), 37347-37360.

Sobko A. Cell biologist’s perspective: Frontiers in Development of PROTAC-HDAC degraders. Preprint. August 2021. doi.org/10.31219/osf.io/vua9r.

Rodrigues DA, Roe A, Griffith D, Chonghaile TN. Advances in the Design and Development of PROTAC-mediated HDAC Degradation. Curr Top Med Chem. 2022 Mar 4;22(5):408-424.

Rodrigues DA, Pedro de S. M. Pinheiro, Fernanda S. Sagrillo, Maria L. Bolognesi, Carlos A. M. Fraga. Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities. Med Res Rev. 2020; 1–35.

Durbin AD, Wang T, Wimalasena VK, Zimmerman MW, Li D, Dharia NV, Mariani L, Shendy NAM, Nance S, Patel AG, Shao Y, Mundada M, Maxham L, Park PMC, Sigua LH, Morita K, Conway AS, Robichaud AL, Perez-Atayde AR, Bikowitz MJ, Quinn TR, Wiest O, Easton J, Schönbrunn E, Bulyk ML, Abraham BJ, Stegmaier K, Look AT, Qi J. EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma. Cancer Discov. 2022 Mar 1;12(3):730-751.

[qualityreagents]

Research Chemical online : You need to know

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Buy Albiflorin chemical

Albiflorin is a striking Chinese person is a fundamental part that has been viewed as a key fixing in Radix Paeonia Alba that has been used to treat ruin issues since the hour of a long while previously. Regardless, the part that drives the upper properties of albiflorin isn't totally seen.

Albiflorin is a uniterpene glycoside, which is the standard fixing in Radix paeoniae alba that is used in conventional fixes all through China, Korea, and Japan. Radix paeoniae alba is generally known as Peony, which is the place of assembly for Paeonia lactiflora Pall, which is head for such Ranunculaceae. Assessment chemical compounds are purchased through a furious technique. In any case, as such a few electronic stores that are certifiable and trustworthy are available where you can buy chemicals online.

The root is among the fundamental pieces of a few standard formulae including Jiaweisinisan similarly as Dang Gui Shao Yao San that is proposed for treating inconvenience related issues. One of these adornments, monoterpene glycosides, for instance, albiflorin and paeoniflorin are routinely seen as the truly original constituents of the peony. Audits have shown that both short and huge length relationship of albiflorin could make all things considered, vague outcomes to antidepressants as shown by a decreasing on schedule of immovability found in the starter of obliged swim tail suspension on mice, and something as opposed not really settled tension started a decrease in sucrose use in rodents. Albiflorin is furthermore associated with goliath energizer impacts, which are excitedly connected to enhancements in hippocampal 5-HT levels and BDNF verbalization that takes after the ordinary upper SSRIs. The monoaminergic system and the receptors that albiflorin targets are unidentified.

Monoterpenoid compound

Albiflorin is a monoterpenoid compound that has a nuclear Formula of 23H 28O 11 and a standard sub-nuclear store of 480.46. The Albiflorin nuclear improvement is fanned out by Formula (I). Albiflorin is a working plan that is isolated from the root from Paeonia lactillora Pall, Paeonia veitchii Lynch in like manner as P. Suffrsticosa Andrz in the Ranuculaceae plant. Albiflorin has a lactone-ring shape at any rate it doesn't have the hemiacetal structure. This understands that it is changed into two blends, paeonilactone An and paeonilactone B under anaerobic conditions.

Consistent examinations in pharmacology recommend that Albiflorin is torment assuaging, anticonvulsant, narcotic impacts, immunosystem-related benefits, smooth-muscle-related effects, quieting impacts, rehearses against pathogenic microorganisms, the liver's guarded effects. To the degree clinical use Albiflorin is used on an exceptionally essential level to treat Epilepsia and nonattendance of pain, recuperation from reliance on cures and treatment for dazedness, the treatment of joint irritation rheumatoid equivalently as treatment of bacillary the runs, as enteritis, treatment for viral hepatitis, and treatment of weights related to age nearly as the weakness to fight the flocculation of normal liquid rot and barium. The cycle used to make Albiflorin and its application for the production of clinical

IUPAC Name

[4-hydroxy-6-methyl-8-oxo-1-[(2S,3R,4S,5S,6R)- 3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-7-oxatricyclo[4.3.0.03,9]nonan-9-yl]methyl benzoate

InChI

InChI=1S/C23H28O11/c1-21-8-13(25)12-7-23(21,33-19-17(28)16(27)15(26)14(9-24)32-19)22(12,20(30)34-21)10-31-18(29)11-5-3-2-4-6-11/h2-6,12-17,19,24-28H,7-10H2,1H3/t12?,13?,14-,15-,16+,17-,19+,21?,22?,23?/m1/s1

Perceived SMILES

CC12CC(C3CC1(C3(C(=O)O2)COC(=O)C4=CC=CC=C4)OC5C(C(C(C(O5)CO)O)O)O)O

Isomeric SMILES

CC12CC(C3CC1(C3(C(=O)O2)COC(=O)C4=CC=CC=C4)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)O

Last Thoughts

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