#cachexia

[bpod-bpod]

Controlling Waste

Elucidating the genes involved in early Fruit fly model of cancer-associated muscle wasting or cachexia used to identify key regulators of glucose metabolism – their imbalance induces muscle degradation

Read the published research paper here

Image from work by Pedro Saavedra and colleagues

Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Nature Communications, August 2023

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[ahb-writes]

Chemoreceptors || Unconventional Senses and Sensory Attributes

❯ ❯ Chemoreceptors

Sensory cells or organs that interact with chemicals in the blood; or more specifically, chemical controls for stimulating or inhibiting respiration. The amount of respiration depends on this neuronal network's response effectiveness. Peripheral chemoreceptors detect large changes in arterial blood oxygen, notably as it relates to the respiratory rate (allowing oxygen into the blood), blood flow (sensitivity to hypoxia), and cardiac output (supplying oxygen to the body). Central chemoreceptors detect changes in arterial carbon dioxide, notably concerning brain blood flow and metabolism, lung ventilation, and pH control (for optimal protein structure and function). A simple example would be to imagine a fantasy novel in which a character or adventurer is impervious (or not) to a gaseous poison that would inhibit proper breathing.

From a more practical standpoint, abnormally enhanced peripheral chemosensory inputs result in an overactivation of the sympathetic nervous system. According to the journal Biological Research, onsetting pathologies can include "hypertension, heart failure, obstructive sleep apnea, chronic obstructive pulmonary disease (e.g., systemic inflammation, muscle dysfunction, and/or cachexia, which is when the body literally wastes away), and metabolic syndrome (e.g., sympathetic hyperactivity, impaired blood-pressure sensitivity)."

❯ ❯ Adapted from a senses-writing masterpost: 15 Unconventional Senses and Sensory Attributes

[biology-geology-beaches-india]

The Science Manuscripts of Satyendra Sunkavally, page 38.

[medicomunicare]

Cancer kills by lactate: how cellular junk becomes a signal to acquire more fuel

Cachexia is a complex metabolic syndrome associated with rapid loss of body weight, mainly loss of fat and lean muscle. Patients with cancer cachexia often develop anemia, fatigue, asthenia and anorexia, which worsen their quality of life and reduce their tolerance to anticancer therapies. As a result, cachexia accounts for approximately 20% of patients with cancer-related deaths. To date,…

[xenodile]

Guess which special girl cleared p6s with the gang in 3 pulls because she’s soooo good at video games >:)

[muravelous]

say goodnight

[marketsizereports]

Global Market Trends: Assessing the Landscape of Cancer Anorexia Cachexia Syndrome Pipeline Drugs Market

the landscape of the Cancer Anorexia Cachexia Syndrome (CACS) pipeline drugs market is characterized by ongoing research and development efforts to address the complex challenges associated with this syndrome. It's important to note that the information provided here is based on the status up to that point, and there may have been further developments since then.

For more target insights, download a free report sample

Here's an assessment of global market trends in the CACS pipeline drugs market:

Key Trends and Observations:

1. Increasing Understanding of CACS:

Advances in understanding the molecular and physiological mechanisms underlying CACS have contributed to the identification of potential drug targets. Researchers are exploring pathways related to inflammation, appetite regulation, and muscle metabolism.

2. Diverse Mechanisms of Action:

The pipeline for CACS includes drugs with diverse mechanisms of action. These mechanisms target pathways involved in appetite regulation, muscle protein synthesis, and inflammation. The diversity reflects the multifactorial nature of CACS.

3. Focus on Appetite Stimulation:

Many drugs in development for CACS aim to address anorexia by stimulating appetite. Ghrelin receptor agonists and other appetite-enhancing agents are being explored to improve food intake and nutritional status in cancer patients.

4. Muscle Mass Preservation and Growth:

Drugs targeting muscle metabolism and protein synthesis are designed to address muscle wasting in CACS. These drugs aim to preserve or enhance lean body mass, contributing to improved functional status and quality of life.

5. Clinical Trials in Various Phases:

Pipeline drugs for CACS are at different stages of clinical development, ranging from early-phase trials (Phase I/II) to advanced-stage trials (Phase III). Advancements in clinical trials are essential to establishing the safety and efficacy of potential treatments.

6. Combination Therapies:

Researchers are exploring combination therapies that target multiple aspects of CACS simultaneously. This approach recognizes the complexity of the syndrome and aims to provide a more comprehensive treatment strategy.

7. Patient-Centric Outcomes:

Clinical trials in the CACS pipeline often prioritize patient-centric outcomes, such as improvements in appetite, weight gain, and overall quality of life. Patient-reported outcomes play a crucial role in assessing the impact of interventions.

8. Regulatory Considerations:

The regulatory landscape for CACS drugs considers not only traditional efficacy and safety endpoints but also outcomes relevant to the patient experience. Regulatory agencies may assess the impact of interventions on symptoms, physical function, and nutritional status.

9. Emerging Companies and Collaborations: - Emerging biopharmaceutical companies, as well as collaborations between industry and academia, contribute to the diversity of drug candidates in the CACS pipeline. Collaborative efforts often leverage complementary expertise to advance research and development.

10. Global Market Dynamics: - The CACS pipeline reflects a global effort, with contributions from researchers, companies, and clinical trial sites around the world. The global nature of research and development efforts highlights the universality of the challenges associated with CACS.

Considerations for Future Developments:

Precision Medicine Approaches:

Advances in understanding the heterogeneity of CACS may lead to precision medicine approaches, tailoring interventions based on individual patient characteristics.

Long-Term Follow-Up Studies:

As drugs progress through clinical development, long-term follow-up studies are essential to assess the sustained impact of interventions on nutritional status, muscle mass, and overall survival.

Health Economic Considerations:

The economic impact of CACS, including healthcare costs associated with hospitalizations and supportive care, may influence the adoption of new interventions. Cost-effectiveness analyses may play a role in market dynamics.

Patient Advocacy and Awareness:

Patient advocacy groups and increased awareness of CACS contribute to a collaborative environment that prioritizes the development of effective treatments. Patient engagement in research and drug development processes is increasingly emphasized.

For the latest and most up-to-date information on the global market trends in the Cancer Anorexia Cachexia Syndrome pipeline drugs market, including recent advancements, clinical trial results, and regulatory developments, it is recommended to consult recent industry reports, scientific publications, and updates from pharmaceutical companies as of the current date in 2023.

[vikasgupta11]

According to the latest report by IMARC Group, titled “Cancer Cachexia Market: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2022-2027,” offers a comprehensive analysis of the industry, which comprises insights on the global cancer cachexia market growth.

[medicomunicare]

Set these "satellites" on their mighty wings: pity Wingless is so "sticky" to forbid the messenger to take off

Set these “satellites” on their mighty wings: pity Wingless is so “sticky” to forbid the messenger to take off

WNT messenger proteins are crucial for a variety of cellular functions. WNT signaling is crucial for the development of organisms and the maintenance of tissue homeostasis, as WNT messengers are involved in a variety of cellular functions. In skeletal muscle, for example, they can increase muscle mass and improve regeneration. Wnt signaling plays a crucial role during the development and…

[bougiebutchbinch]

yo.... what if wade had cachexia (cancer-induced severe wasting; cannot put on or keep on weight)? Like, zero appetite, no ability to maintain muscle mass or body fat, scary-low bmi. Man is caught at late-stage metastatic cancer, but he just cannot die.

[tempural]

Started with this B/W sketchbook drawing. Got inspired by the look of the sketchbook spiral on the side, cuz it looked like film notches. Made me think of x-ray scans. Ended up doing the whole medical route on the final drawing.

Coloring method was mostly pressing the "invert" tool to turn the canvas black. Then painting red/yellow with gradient maps. And then drawing the glowing blue lines, as well as typing the "medical" text, on an "add" layer.

Spoilers and long head canons and unlicensed medical talk under the cut.

The text reads:

REVIEWED BY PONY EXPRESS AUTODOC MODEL-SCUMSUCK

PATIENT: CURLY

Near total body disruption from explosive decompression

Complete dermal vascular system collapse

Severe radiation poisoning

Hyperosmolar hyperglycemic state

Muscle and bone cachexia

Single eye rupture

Chronic obstructive pulmonary

Testicular rupture

Severe leukopenia

Itchiness and dry eye

RECOMMENDED TREATMENT

Administer intravenous therapy and catheter

Support neck and spine

Change bandages as supplies last

Orally administer paracetamol for pain

Turn and reposition patient every 2 hours to prevent bed sores

Create relaxing enviroment

Listen attentively to understand emotional state

Allow time for exercise and meditation

Encourage positive thinking

Brush teeth

Administer mouthwash

SIGNED OFF BY DOCTOR ANYA

Of course none of the treatment is actually good. In the game itself, you give him paracetamol (TYLENOL) for pain haha. So I thought I'd go along with the bad medical advice. Including that universal medical advice you get to do "exercise and meditation" if you are in a bad mood :)

I think I spent about as much time looking up the medical stuff (specifically things in relation to explosion damage and radiation damage - thinking of the Byford Dolphin Incident as well as Hisashi Ouchi) as I did with the coloring! We don't know what exactly happened with Curly, but I'd just guess with my lack of medical knowledge that the ship crashed, something exploded, and he was exposed to intense radiation.

Realistically he wouldn't be surviving with the level of medical care they have available on the ship, so I drew a couple things I thought would help him... namely the IV and catheter haha. Also thought it'd be a fun time to introduce my favorite headcanon to gift cute characters: the gift of genital nullification. Yes, I drew this mostly to show off my not-buff and no-pp headcanons!!!!

I like Curly with no skin, no muscle, no hair. It's ok if he had those before. I probably wouldn't draw him "recovered" with perfectly functioning prosthetic limbs and magically regrown vocal cords and sexy 8 pack abs. That's just me. He could get a wheelchair, perhaps some sort of eye controlled assisted communication like Stephen Hawking (but Curly doesn't seem to be able to control his jaw or cheek?).

Thinking about ~da dystopian future~ and what support he would even get? His job ain't gettin him anything :P He doesn't seem to be in the sort of society with universal healthcare, they'd drain his savings and then put him in a dark room with a nurse that turns him over once every 24 hours... Well, that's if they find him. I think he's staying frozen for 20 years and then melting like Walt Disney once the power runs out.

[hauntexd-house]

“Omg in your design you twinkified Wallter!”

IF YOU LOOK CLOSELY . REALLY CLOSELY. THOSE WHO DEVELOP SEVERE ILLNESSES START LOOSING UNHEALTHY AMMOUNTS OF WEIGHT BECAUSE GHEIR BODY CAN DEVELOP CACHEXIA!!

CAUSE THEIR BODY IS FIGHTING SOMETHING, ITS NOT PROCESSING THINGS CORRECTLY!!

SO TYHEIR GONNA LOOSE UNHEALTHY AMMOUNTS OF WEIGHT!!

[chronicpaingirlie]

thinking about this poem again today. id below the cut

[ID: a screenshot of the poem ‘cachexia’ by max ritvo. it reads:

Today I woke up in my body

and wasn’t that body anymore.

 It’s more like my dog—

for the most part obedient,

warming to me

when I slip it goldfish or toast,

 but it sheds.

Can’t get past a simple sit,

stay, turn over. House-trained, but not entirely.

 This doesn’t mean it’s time to say goodbye.

 I’ve realized the estrangement

is temporary, and for my own good:

 My body’s work to break the world

into bricks and sticks

has turned inward. 

As all the doors in the world

grow heavy

a big white bed is being put up in my heart.]

[lactodebillus-bulgaricus]

I just realized something regarding hetalia bulgaria (this gets dark, check tw before clicking on keep reading)

y'know, he's portrayed as skinny and lacking muscles in hetalia

irl, bulgaria is the country with fastest declining population in the world, largely due to emigration and low birth rate, as well as one of the countries with highest death rate

so maybe he's suffering from cachexia, a medical condition where you lose weight & (mainly) muscle mass even though you don't want to, and perhaps it's due to his population decline

maybe it started in 1989 when the communists lost power, the borders opened and the economy became worse than before for several years, prior to this, in 1989, the population of bulgaria was 9 million, now, in 2024, it's 6,5 million

in humans, cachexia is most common with people who have late stage cancer, or aids, or untreatable chronic diseases such as copd or chronic kidney failure, maybe the corrupt politicians & the oligarchs & mafia are something like cancer or another severe disease to him?

[scotianostra]

When we talk about brave people, in my eyes few can surpass the bravery of Jane Haining, who was born on June 6th 1897 in Dunscore, Dumfries & Galloway.

It’s only in the past few years that Jane Haining has justifiably, been given her place in history, I’ve know of her story for a number of years, thanks mainly to the small plaque on The Vigil Monument on Calton hill.

Jane lost her mother at the age of five and grew up a determined, capable woman. She worked for ten years in a threadmaker’s in Paisley, but at a meeting in Glasgow about the Jewish Mission she turned to a friend and said, prophetically: ‘I have found my life-work.’ She got the call to work at a Church of Scotland mission to the Jews in Budapest in 1932.

Famous for her broad Scots accent, she was popular with the 400 children, a mix of Christians and Jews, attending the school. Many were orphans, from broken or poverty-stricken homes, while others were sent simply because they got an excellent education from the Scots.

She loved her little ones. In one letter, she wrote: 'We have one nice little mite who is an orphan and is coming to school for the first time. She seems to be a lonely wee soul and needs lots of love. We shall see what we can do to make life a little happier for her.’

Another letter read: 'We have one new little six-year-old, an orphan without a mother or a father. She is such a pathetic wee soul to look at and I fear, poor lamb, has not been in too good surroundings before she came to us .. she certainly does look as though she needs heaps and heaps of love.’

She was in Scotland on leave when World War 2 broke out, but immediately undertook the hazardous journey back to Budapest to help the Jewish children.

Later the missionaries were ordered back to Scotland to safety when the Nazis invaded Hungary in 1944. Jane Haining disobeyed and remained to take care of her children. 'If these children need me in the days of sunshine’, she said, 'how much more do they need me in the days of darkness?’ Her sister Nan O'Brien later recalled: 'It was no surprise that she refused to come back. She would never have had a moment’s happiness if she had come home and left the children.“

During the war the Nazi brutality accelerated with murder, violence and terror and the little Jewish children were increasingly under threat. Jane protected them to the best of her ability.

Jane Haining was denounced to the Nazi authorities and SS men raided the place early in May. They searched her office and her bedroom, gave her 15 minutes to get ready and took her away. She was thrown in jail on charges of British espionage and helping Jews. She was accused of working among Jews and of weeping! She wept as she had to sew the yellow stars of David onto the dresses of her children .

One of her former wards later recalled: 'I still feel the tears in my eyes and hear in my ears the siren of the Gestapo motor car. I see the smile on her face while she bade me farewell. I never saw Miss Haining again, and when I went to the Scottish Mission to ask the minister about her, I was told she had died. I did not want to believe it, nor to understand, but a long time later I realised that she had died for me, and for others. The body of Miss Haining is dead, but she is not alone, because her smile, voice and face are still in my heart.’

Jane Haining was deported along with some of her Jewish children to the death camp Auschwitz. In three months 1,300,000 were liquidated in Auschwitz, among them No. 79467, Jane Haining, who refused to reject her children and showed herself to be a saint. She died for her beliefs and was gassed along with a batch of Hungarian women on August 16th, 1944, at the age of 47.

Because Jane Haining was a British citizen and passport-holder, the Church of Scotland was sent her death certificate from Auschwitz: 'Miss Haining, who was arrested on account of justified suspicion of espionage against Germany, died in hospital, July 17, of cachexia brought on by intestinal catarrh.’

In 1997 Yad Vashem, the Holocaust Martyrs and Heroes Memorial in Jerusalem, awarded Jane Haining a medal and a place among the Righteous Among the Nations for her selfless dedication to the children. The award was presented to her sister, Nan O'Brien of Londonderry, Northern Ireland, by the Israeli Ambassador to Britain at a ceremony in Glasgow.

She is remembered in the stained-glass windows of Queen’s Park Church in Glasgow and at the Church in Dunscore, as well as a memorial there, as seen in the pics, in book form. A plaque remembers her aerected by the Budapest Jewish community, 1984.Vorosmarty utca 51, Budapest. Jaane is also remebered on Jerusalem Yad Vashem Memorial Hall of Names

In 2017 Jane Haining was honoured by the city of Budapest being the focus of a new exhibition in the Holocaust Memorial Centre. Zoltan Toth-Heinmann, the centre spokesman stated that he was determined to ensure that as many people as possible learn about Haining, who was posthumously honoured by the British Government for "preserving life in the face of persecution”

[whymaige]

🥀 Cachexia 🥀