#biomarker study

[dermatology-cro]

[chahaa-piun-ja]

re: the last post but still a bit tangential - the broader fields of evolution, genetics and biostatistics (and the narrower field of human population genetics) have not fully reckoned with their extremely racist and eugenicist roots. why are people still being taught about some of the giants in the field (Fisher etc) without also mentioning that they were huge proponents of eugenics. scientific racism was a thing because early evolution and genetics people absolutely believed that their nascent science could be employed as a tool of racism (some still do)!

[jcmarchi]

Unlocking history with geology and genetics

New Post has been published on https://thedigitalinsider.com/unlocking-history-with-geology-and-genetics/

Unlocking history with geology and genetics

Fatima Husain grew up in the heart of the Midwest, surrounded by agriculture. “Every time you left your home, you saw fields of corn and soybeans. And it was really quite beautiful,” she says. During elementary school, she developed her own love of gardening and cultivated a small plot in her family’s backyard.

“Having the freedom to make a mess, experiment, and see things grow was very impactful,” says Husain, a fourth-year doctoral candidate in the MIT Department of Earth, Atmospheric and Planetary Sciences (EAPS) and a Hugh Hampton Young Fellow. This experimentation in the garden was the seed that blossomed into her fascination with science. “When you think about gardening and agriculture in Iowa,” she says, “you think about soil and its origins, which led me to geology and geochemistry and all these interdisciplinary fields that play a role in the Earth sciences.”

Husain has maintained that scientific curiosity throughout her academic career. As a graduate student in EAPS’ Program in Geology, Geochemistry, and Geobiology, she studies the fossil and genetic records of ancient and modern life forms to better understand the history of life on Earth. She says, “Twenty years ago, I was a stoked kid working with topsoil in Iowa. Now, I get to work with ancient dirt and sediments to better understand Earth and life’s past.” 

Sharing science

Though Husain loved her environmental science class in high school, when she enrolled at Brown University, she wasn’t sure which STEM major to pursue. Then, a guest lecture in her first-year biology course dispelled any uncertainty. “A professor walked on stage and introduced himself as a biogeochemist, and after that, everything just clicked,” she says. Within weeks of that fateful lecture, she had declared a major in geochemistry. “I’ve never looked back,” she says.

She then immersed herself in her Earth science classes, which applied the core science disciplines she studied to topics such as the oceans, weather and climate, and water quality. “I gained a sincere appreciation for the excellent teaching and writing that helped me access the world of the geosciences,” she says, “And that helped me realize the value in communicating science clearly.”

To hone her writing skills, Husain took nonfiction writing classes as her electives and joined one of the school newspapers. There, she took on the role of science writer and editor. As she neared graduation, she knew that she would eventually pursue geochemistry at the graduate level, but first she wanted to focus on journalism and writing. She reasoned that, if she could formally learn the fundamentals of science writing and reporting, then “I could more effectively share all the science I learned after that point,” she says. With the support of her undergraduate professors, she decided to apply to MIT’s Graduate Program in Science Writing, one of the only such programs in the country.

The program refined Husain’s writing skills and paved the way for her to pursue science journalism opportunities across a variety of media, including print, video, podcasting, and radio. She worked as a writing intern for MIT News during this time, and has written a number of MIT News articles while at MIT. After graduating, she served as a Curiosity Correspondent for the MIT-Nord Anglia Education Collaboration based at the MIT Museum. In that role, she says, “I worked on communicating the amazing science happening here at MIT to K-12 students around the world via educational videos.” Since beginning her PhD studies, Husain has transitioned to a new role in the collaboration — hosting a monthly webinar series called MIT Abstracts, which connects MIT researchers and experts with an international audience of middle schoolers.

Along the way, Husain has also worked as a reporter and managing producer for a Rhode Island-based sustainability science radio show called Possibly. In 2019, she founded a podcast with her colleagues called BIOmarkers, which serves as an oral history project for the discipline of organic geochemistry.

Acquiring the “biggest tool set” possible

After completing her master’s thesis, Husain began to return to her roots in geochemistry. She says, “At some point, when I was interviewing other scientists and they described their experiments, I’d miss being in the lab myself. That feeling helped me realize the time was right to get back into research.” Husain chose to stay at MIT for her PhD. “I couldn’t resist the opportunity to continue working on challenging, interdisciplinary problems within such an exciting environment,” she says. “There really is no other place quite like it.”

She joined the lab group of Roger Summons, the Schlumberger Professor of Geobiology. For her first project as a research assistant, Husain helped then-postdoc Ainara Sistiaga reconstruct the environment of Tanzania’s Olduvai Gorge 1.7 million years into the past, using molecule-scale fossils preserved in archeological sediments. Part of Africa’s Great Rift Valley, the site preserves evidence of ancient hominin tools and activities. The research team’s findings were later published in published in PNAS.

Under the mentorship of her advisors, Gregory Fournier, an associate professor of geobiology, and Summons, Husain studies both the fossil record and the genetic records of organisms alive today to answer fundamental questions about life’s evolution on Earth. “The farther back into Earth’s history we go, the fewer complete records we have,” Husain says, “To answer the questions that arise, I hope to employ the biggest tool set I can.”

Currently, Husain investigates the biomarkers of microbes living in Antarctic biofilms, which she hopes will provide hints about the types of places where the ancestors of complex life sheltered during global glaciation events through Earth’s Cryogenian period, which stretched between 720 to 635 million years ago. To do this, Husain applies techniques from chemistry, such as chromatography and mass spectrometry, to isolate and study microbial lipids, the precursors of molecular fossils preserved in the geologic record.

Husain also uses “molecular clocks,” tools which employ the genetic sequences of living organisms to estimate when in evolutionary time different species diverged, to better understand how long ago aerobic respiration arose on Earth. Using the growing databases of publicly available gene sequences, Husain says it’s possible to track the histories of metabolisms that arose billions of years ago in Earth’s past. Much of her research can also be applied to astrobiology, the study of potential life elsewhere in the universe.

As a PhD student, Husain has also had the opportunity to serve as teaching assistant for 12.885 (Science, Politics, and Environmental Policy) for two semesters. In that role, she says, “My goal is to help students improve their writing skills so that they are equipped to successfully communicate about important issues in science and policy in the future.”

Looking ahead, Husain hopes to continue applying both her science and communication skills to challenging problems related to Earth and the environment. Along the way, she knows that she wants to share the opportunities that she had with others. “Whichever form it takes,” she says, “I hope to play a role in cultivating the same types of supportive environments which have led me here.”  

[deinheilpraktiker]

Eine neue genetisch zielgerichtete MND-Therapie könnte einen Wendepunkt für die Patientenversorgung bedeuten

Wissenschaftler glauben, dass eine neue genetisch zielgerichtete Therapie zur Behandlung von Motoneuronerkrankungen (MND) einen Wendepunkt für die Patientenversorgung darstellen könnte, nachdem die Ergebnisse einer klinischen Phase-3-Studie nach 12 Monaten erhebliche körperliche Vorteile für Patienten gezeigt haben. Forscher des Sheffield Institute for Translational Neuroscience (SITraN) fanden…

[mindblowingscience]

Teenagers who regularly puff away on their vape throughout the day could be exposing their bodies to potentially toxic metals. A new study led by researchers from the University of Nebraska has found that regular vapers between the ages of 13 and 17, who report using an e-cigarette at least eight times a day, have 30 percent more lead and twice as much uranium in their urine compared to their peers who only occasionally vape. Among teens who preferred sweet vape flavors, as opposed to menthol or mint ones, biomarkers of uranium were especially high. The research lacks a control group of teens who did not vape at all, but the pattern evident within a US sample of 200 e-cigarette users who avoided cigarettes is still concerning. For the sake of public health, the researchers argue for further investigation into the potential toxicity of e-cigarettes. The results of this small study do not prove that vaping causes toxic metal accumulation in the body, but previous analyses have consistently found signs of toxic metals in e-cigarette aerosol samples and in the bodily fluid of vapers. At times, the blood and urine samples of vapers rival even those of cigarette smokers.

Continue Reading.

[covid-safer-hotties]

Quick aside: The people claiming they have Long Covid because of covid vaccination need to prove it. The scientists studying the phenomenon need to prove it. You know who never give us the specific antibody titers of these supposed vaccine injuries? The people who claim they've "never had covid" based on .... vibes(?) and the scientists studying them. Weird how they have near-identical symptoms and biomarkers to people who get Long Covid from an infection! It couldn't be that they're lying or had an asymptomatic infection and never knew they were sick! Nope! It's the jab! Make sure to hesitate about your next vaccination!

[transmutationisms]

i was wondering where this obviously bullshit claim came from and the answer is it's this study done on israeli citizens with access to healthcare who were between the ages of 51 and 70 at the start and had not been previously diagnosed with adhd or dementia, meaning those diagnosed with adhd received that diagnosis (subjective) (there is no biomarker or lesion or physiological defect) past the age of 51 and also the study includes this line:

lol. lmao, even

[religion-is-a-mental-illness]

We have a serious problem

Michael Laidlaw, MD: I'm a board-certified endocrinologist, practicing in private practice for the last 16 years. I've been studying and publishing in this area for the last 5 years, including peer reviewed journals such as Journal of of Clinical Endocrinology and Metabolism, and others. I also have a patient who is a detransitioner.

I think it's important to note that studies are shown that desistance, or growing out of this condition, of children by adulthood is very high. It's some 50-98%.

I want to be sure before I give someone a very powerful hormone like Insulin that they in fact have diabetes.

What about cancer? Before we give any powerful agents such as chemotherapeutics or surgeries, we certainly want to have physical evidence of this problem, such as biopsies or imaging.

Now, the gender affirmative therapy treatment proposed by WPATH gives very powerful hormones and surgeries on what basis? Where can we find the gender identity to be certain that these children will not desist by adulthood? Can we use imaging of the brain or blood tests, genetic testing, are there other biomarkers to ensure that we are correct? There is no such thing.

Julia Mason, MD: The Endocrine Society put out guidelines in 2017, and they were very careful in the guidelines. One, to point out that the evidence was of low and very low quality. And they also said in the guidelines that they have no idea how you identify which kids are trans and require this treatment.

And then the American Academy of Pediatrics the next year just leapt into that void and said, oh, oh, we'll tell you how you know which kids. You ask them.

Prior to 2018 I had maybe one trans patient. But then there was another one. And another one. And another one.

It wasn't until later that I started asking questions like, wait, every single kid I send to the gender clinic gets put on puberty blockers or cross-sex hormones. Just, it was happening immediately.

Patrick Hunter, MD: This affirmative model of care has spread wildly in the last 8 years. Now we have objective, unbiased systematic reviews. These systematic reviews tell us the evidence for youth transition is poor quality, and with very low certainty for benefit.

In JAMA Pediatrics, there was a study reported from Northwestern University in Chicago. Patients ranged in age from 13 to 24 years. The authors concluded that mastectomy was beneficial and should not be delayed in youth. What lead them to that conclusion? The finding that 3 months after surgery, the 36 patients were happy with their flat chests. They lost 9% of their surgical cases to follow-up. Nine percent. In 3 months.

It is absurd, meaningless to draw any conclusions after 3 months.

This paper is indicative of the quality of research we have in this field, published in our most prestigious journals.

We have a serious problem.

[reasonsforhope]

Researchers from Western and Brown University have made groundbreaking progress towards identifying the root cause and potential therapy for preeclampsia.

The pregnancy complication affects up to eight per cent of pregnancies globally and is the leading cause of maternal and fetal mortality due to premature delivery, complications with the placenta and lack of oxygen.

The research, led by Drs. Kun Ping Lu and Xiao Zhen Zhou at Western, and Drs. Surendra Sharma and Sukanta Jash at Brown, has identified a toxic protein, cis P-tau, in the blood and placenta of preeclampsia patients.

According to the study published in Nature Communications, cis P-tau is a central circulating driver of preeclampsia – a “troublemaker” that plays a major role in causing the deadly complication...

“The root cause of preeclampsia has (so far) remained unknown, and without a known cause there has been no cure. Preterm delivery is the only life-saving measure,” said Lu, professor of biochemistry and oncology at  Schulich School of Medicine & Dentistry...

“Our study identifies cis P-tau as a crucial culprit and biomarker for preeclampsia. It can be used for early diagnosis of the complication and is a crucial therapeutic target,” said Sharma...

Until now, cis P-tau was mainly associated with neurological disorders like Alzheimer’s disease, traumatic brain injuries (TBI) and stroke. This association was discovered by Lu and Zhou in 2015 as a result of their decades of research on the role of tau protein in cancer and Alzheimer’s.

An antibody developed by Zhou in 2012 to target only the toxic protein while leaving its healthy counterpart unscathed is currently undergoing clinical trials in human patients suffering from TBI and Alzheimer’s Disease. The antibody has shown promising results in animal models and human cell cultures in treating the brain conditions.

The researchers were curious whether the same antibody could work as a potential treatment for preeclampsia. Upon testing the antibody in mouse models they found astonishing results.

“In this study, we found the cis P-tau antibody efficiently depleted the toxic protein in the blood and placenta, and corrected all features associated with preeclampsia in mice. Clinical features of preeclampsia, like elevated blood pressure, excessive protein in urine and fetal growth restriction, among others, were eliminated and pregnancy was normal,” said Sharma.

Sharma and his team at Brown have been working on developing an assay for early detection of preeclampsia and therapies to treat the condition. He believes the findings of this study have brought them closer to their goal...

“The results have far-reaching implications. This could revolutionize how we understand and treat a range of conditions, from pregnancy-related issues to brain disorders,” said Lu.

-via India Education Diary, September 22, 2023

[sysmedsaresexist]

News Flash ⚡

A neurostructural biomarker of dissociative amnesia: a hippocampal study in dissociative identity disorder

Another study provides evidence that emotional neglect in childhood is the biggest indicator of DID.

[thelunastusco]

We have the disorder.

Endogenic systems still exist.

Sunni can laugh at it, Anna can roll her eyes, Shiloh can sigh and shrug their shoulders, but anti-endos refusing to read just really pisses me the fuck off.

I think it's the smug "we're so much smarter than those stupid endogenic fakers" energy that so many of them have and for this particular time the "just give us some sources proving you exist" thing on top of the refusing to read the sources we give that really grinds my gears.

If you can't be bothered to read sources we give you, QUIT ASKING FOR THEM.

Ye gods.

[darkmaga-returns]

By GreenMedInfo Research Group

A new epidemiological study found that fluoride exposure from drinking water associates with decreased testosterone levels in young and middle-aged men.

Testosterone dropped most sharply in 18-39 year-olds based on fluoride burden. Surprisingly, in older men with higher fluoride exposure, testosterone increased with age instead of declining as expected. This complex relationship hints that fluoride may disrupt multiple hormonal pathways beyond the male reproductive axis.

A novel study reveals fluoride affects serum testosterone in a complex, age-specific manner, adding evidence that environmental toxicants may contribute to declining hormonal function in younger males.

Published in Biological Trace Element Research, the cross-sectional study examined fluoride exposure and two reproductive biomarkers, testosterone and androgen binding protein (ABP), in over 300 Chinese farmers.1 Scientists divided participants into higher and lower fluoride exposure groups based on urinary fluoride levels.

Compared to the lower exposure group, men with elevated fluoride measured significantly lower testosterone overall. This depletion was most pronounced in 18-39 year olds. Paradoxically, among higher-exposed middle aged and older men, testosterone increased slightly with age instead of undergoing the expected age-related decline.

Meanwhile, ABP remained unaffected across groups regardless of fluoride burden and age. As ABP governs testosterone transport and tissue uptake, results indicate fluoride direct

[axel-mania]

Huge discovery just came out. There is likely now a reliable biomarker for the disease I probably have, which has lead to nerve damage that has affected me in a variety of ways. Ehlers-Danlos is mainly known for being a genetic disease of improper collagen production, which ends up fucking with most body systems.

There are many subtypes, but the most common, hypermobile, had no genetic marker. This meant that it was almost impossible to get a diagnosis, with most doctors not even acknowledging its existence, and anyone without obvious enough dysfunction getting told they didn't "really" have EDS, just hypermobility, so there's no point in treating them. But now it seems that there is no such distinction between just hypermobility and EDS, as the same biomarker was found in the blood of everyone with that set of symptoms.

If we have an easy blood test a PCP can order to tell whether or not you have EDS, then things get easier as far as accessing specialists, getting disability payments, etc. But treatment is in a pretty bad place for us with or without a diagnosis, so it's not exactly a huge hurrah. Obviously plenty of genetic diseases with obvious markers are still associated with heavy medical malpractice and just getting told to exercise and take Tylenol. Still, this feels really good. I hope I live to get this test done.

[seeingivy]

elevated heart rates 

levi ackerman x f!reader

levi’s a mind reader and you’re a love expert 

content: grad student levi, brain researchers, nile being a weirdo freak (sorry yall), mentions of drinking, levi is shirtless at one point, reader has claustrophobia 

an: started my big girl brain research fellowship today. hence - brain jargon and GRAD STUDENT LEVI

- 

The room is small - the nineteen of you cramming into the small space of the conference room. You’re located directly at the front, sitting next to your advisor, Dot Pyxis. A leading expert in the field, one of the first neuroscientists you had met at a conference when you were a freshman in college. 

You saw it - the way his eyes lighted up, the way he was stumbling over his words because he was so excited to explain what he did everyday that you wanted that. To be that excited about something. And here you were, sitting next to him about to make it happen. 

You moved to Marley two months ago for this very moment. Your first day at the Brain Consortium - one of the best neuroscience research labs in the country, led by Pyxis himself. He was going to co-advise your thesis, guide you into becoming an expert in the field. Unlike any other, this lab was barely limited to one field, instead equipped with researchers from many different departments, the projects, the papers entirely interdisciplinary. 

There was no other place like it. You can feel your hands shaking as you hand over your hard drive, your presentation loaded on to it. Pyxis had explained it all - there were weekly lab meetings where everyone came together, presenting their research. Everyone gave feedback, asked questions to help further expand and build on the projects. 

And it was your turn. On your very first day, you were expected to explain. What you were going to research, what you were going to contribute, what you were excited about. 

It’s fucking nerve wracking. Pyxis stands up, giving you one last shoulder squeeze, before introducing everyone in the lab to you. He points everyone out - the other assistant professors, post-doctoral researchers, and the other PhD students. 

“Hange Zoe, Erwin Smith, Levi Ackerman, Petra Ral, and Nile Dok. The other PhD students. I want the five of you to give her a tour of the lab after.” 

They all nod, a few of them giving you encouraging smiles as you start. Pyxis turns to you, taking your seat at the table as you take the pointer in your hands, starting your presentation. 

“Right. Um, I’m F/N L/N. It’s nice to meet you all. I, um, completed my undergraduate studies at Shiganshina University. I got a b-bachelors in applied neuroscience and computational biology. I’ll be presenting my thesis project pr-proposal.” 

You hate this shit. You’re stuttering over your words and they’re all staring back, completely uninterested in your work. The PhD students in front of you aren’t even taking you seriously - the girl with glasses nearly stumbling off her chair from sliding around on it and the guy with dark black, grey steely eyes more interested in his cup of fucking tea than what you were talking about. 

“Right, so. My project aims to study interoceptive signals - like heartbeat, respiration cycles, blood pressure - and use them to predict and decode intentions. These small biomarkers, entirely unconscious to us, are consistent during decision making, unbeknownst to us. We can exploit that - to understand higher level cognition.” 

You’ve got their attention - you can tell. This is always the easy part, drawing them in - the woman from before stopped sliding on her chair, instead leaning forward with her eyes shining at your slides, the guy with the tea momentarily flickering his eyes up to the screen. 

“You can use it to predict how people act, how they feel. Especially for something like heart rate, which is what I want to focus on, you can understand so many things - anxiety, stress, companionship, sexual attraction, romance.” 

You see one of the PhD students murmur under his breath, interrupting you in your stead. Nile, they said his name was. 

“So you want to be a…love expert?” 

The entire room laughs, giving you smiles as you continue on. You give him a smile, responding. 

“I guess you could say that.” 

You continue on - highlighting how the brain regulates these signals, what equipment you’ll be using to record all of it. 

They clap when you’re done. Success. 

 - 

You feel fully settled into the lab, a few months later. You’ve decorated your tiny cubicle, directly in the middle with the other PhD students, with a few knick knacks - a picture of you and your best friend, a tiny little green figurine your parents gifted you, and a rack for your headphones. 

You’re located in the section with the other PhD students, who are…interesting. 

On the first day, they lead you to take the cubicle directly next to Hange, which you realized was a bad idea. Because they set you up. Hange’s a biochemist - doing research on the brain tissue at the molecular level, trying to understand how glioblastomas progress. Meaning - they’re always playing with chemicals at their desk, sometimes too lazy to walk over to the lab, which leads to some interesting smells and…smokes in your area. 

They never get in trouble, because Erwin and Petra always come to save the day. They’re both leading policy experts, studying volition and decision making in hopes to use in applications to the law and judicial systems. Figuring out why criminals commit crimes, using it for to serve justice. They cover up the evidence, distract Pyxis and Shadis, and talk their way out of it on Hange’s behalf. 

And that leaves Nile, who isn’t particularly your favorite. He’s a bit hard to get along with, not exactly personable per say. He’s researching microdosing and addiction - trying to figure out how we can manipulate medicines or drugs into being more or less addictive. 

You almost forgot about him. Levi, who's currently leading you to the MRI room on the other side of the building. Definitely the most intriguing of all of your colleagues - using transcranial brain stimulation to decode intentions. In less jargony terms, he read minds. 

He puts the decisions made on the tests into algorithms, correcting it until the machines can predict the decisions being made perfectly - that can be applied to anyone, not just singular participants. He’s coding human thought into machines. And doing it successfully. 

Levi’s quiet, perplexing, and intelligent. An enigma. He’s stood out to you, more than anyone else, for the simple reason that he’s the only one who doesn’t want to talk to you. Hange invites you out for drinks, Petra introduced you to her boyfriend, Erwin bought you a birthday present even though you didn’t tell anyone it was your birthday, and Nile asked you on a date (which you obviously declined). 

But Levi doesn’t care. You don’t either, but it does intrigue you at times. Why he’s so quiet, so closed off, what he’s always doing on his laptop, who he texts on his breaks. This was the first time you were alone with him - getting roped into participating in his newest study. 

“Newbie has to do it.” 

“Do what, Hange?” 

“Levi likes to experiment on all of our brains. You’ve never done it and he needs someone, so we’re volunteering you.” 

Hange and Erwin pull you up by the wrists, all but pushing you out of the conference room into Levi’s cubicle, where you almost trip and fall over him. He looks up - already deeply uninterested with the three of you standing in his space - as he removes his hands from his keyboard. 

“What, brats?” 

“I’m not participating. She is. Take her away!” 

He looks between the three of you, clearly unamused with how nonchalant Hange was being about the whole thing, as they knocked over Levi’s stack of books on the floom. They nearly shake his entire frame in their hands as they thanked him profusely for not making them participate. 

Erwin picks up the stack of books - somehow shuffling them all out of order as Levi gets even more frustrated - shooing the two of them out of his space. After successfully removing them, you and Levi walk towards the MRI room, all the way across the building, in silence. 

When you get there, he taps his hand on the platform, signaling for you to sit on it. You obediently follow, still not uttering an entire word. You watch him mill around the room - pressing switches, using the intercom to communicate with the operator, turning the lights off. 

“Wearing any metal?” 

“My necklace. I’ll take it off.” 

You reach up, awkwardly fumbling with the clasp as he watches you, his hands pressed to his sides as he waits. You’re not sure what it is - how sweaty your hands are, the way he’s looking at you, awkwardly waiting for you to finish - but you can’t get the clasp off, your hold shaking behind your hair. 

“I can help you.” 

You meekly nod, getting off the platform. Before you can, he reaches forward, his slender hands gathering your hair before placing them across the side to your shoulder. You feel his knuckles against your nape, quickly unlatching the necklace and fixing your hair back into place. 

“I’ll hold it for you.” 

You get back onto the platform, lying flat, as Levi uses the intercom to signal to Armin, one of the undergraduate students who worked in the MRI building. You can feel the platform sliding you into the tube and you suddenly feel it. 

Your claustrophobia. Every horrible thought you can imagine is running through your head as the machine starts whirring, your heart pounding in your chest. An earthquake - the machine would crush you. The magnets can be too fast, the machine malfunctioning while you’re stuck inside it. There could be a fire and you would be left here, everyone leaving you and locking you out of the room. 

“You okay?” 

“Y-yeah, Armin. Sorry. I get a bit claustrophobic, that’s all.” 

“Okay, take your time. Try to stay still so we can get better pictures.” 

You nod, trying to still your breaths as the machine whirrs on again. You can feel your nails digging into your palms, as you try to calm down, the panic still sitting in your chest. You feel a hand circle around your ankle, squeezing twice, as the machine keeps going. 

“You okay, Newbie?” 

“Yeah, Levi. I’m okay.” 

“I’m here. Get out if you’re uncomfortable. I’ll just drag Shitty Glasses by the scalp to do it instead of you.” 

You laugh, his hold still firm on your ankle. You try to focus on it - the fine print on the machine, your back against the platform, his fingers on your skin as the machine keeps going, your panic still writhing in your chest. The MRI finishes - Levi giving you one last squeeze before the platform slides out and you nearly jump out of the machine. 

You and Levi walk back to the main lab, in silence. When you get there, Levi gives Hange’s ponytail one big yank before settling back into his cubicle, giving you a soft smile before you return to yours. 

-   

It’s Levi’s turn to present for the lab meeting. The lab is going to Hizuru for Sigtuna, one of the largest neuroscience conferences to date. The PhD students are all presenting posters, except Levi who was invited to give a talk. 

You had been helping Levi as of late - working with him to identify the sulcuses and the lobes on all of Levi’s MRIs. He had no experience in magnetic resonance imaging whatsoever - something you had spent years learning during undergrad. So the two of you had worked out a system - you helped him with identifying the images and helped you troubleshoot your code for your tasks whenever you needed it (which was often). 

You spent a lot of time together - even if it wasn’t direct. You’d sit in silence in the main conference room, working for hours. He’d bring you a cup of coffee and you would pick up dinner, talking through ideas as you finished off your projects. 

You had helped him write the grant for the talk instead of the poster, helping him with all the physiological portions. He taught you how to do all the analysis for yours - the two of you often the one’s leaving the lab latest, Levi walking you to your car in the dark before walking off to his own. 

You were friends. Project partners. 

He gives you one last look before starting the presentation and you shoot him a thumbs up under the table, which he returns with a smile. He’s explaining - using your brain and Hange’s as the sample templates to explain what he was doing - what parts of the brain he has to use for his machine learning. 

“This is Newbie’s and this is Hange’s brain. In theory, each part of the brain is slightly bigger, depending on what parts of your brain you exercise more. For example, Hange is involved in more motor-dexterity - running all their projects by hand. This part of the sulcus is more developed, bigger because of it, compared to Newbie.” 

Nile nudges you on the side, whispering something about how he can give you something to do with your hands if you needed it. You roll your eyes, awkwardly shuffling farther as you refocus on what Levi was saying. 

“This part of the brain is more developed for Newbie, the Brodmann areas - associated with critical thinking, higher level cognition, decision making. Good thing I didn’t use your brain, Dok. We wouldn’t even be able to catch it on the image if we used yours.” 

The entire room laughs - Nile sulking in his chair as Levi continues. You don’t miss the look he gives you afterwards, his eyes uncharacteristically soft when he meets yours, as he continues the presentation. 

When he finishes, Pyxis goes over the room assignments, mentioning that there were three rooms for all the PhD students - meaning a few of you would have to pair up. You turn your neck to look at Petra, who's already nodding and agreeing with Hange that they would room together. You deflate, watching Erwin and Levi pair up. Which leaves you next to Nile, who's all but too excited to be your partner. 

He slings his arm around your shoulder, saying that you guys can share the bed if it gets cold at night, which leaves you shooting dangerous looks at Hange. Levi catches on first, immediately dragging Erwin over to where the two of you were standing. 

“Dok. Erwin is going to room with you.” 

“Says who?” 

“Says me. Don’t argue with me today, I’m already sick of you.” 

Levi grabs you by the wrist, dragging you towards the other side of the room as he rambles on. 

“What a fucking idiot. First he interrupts me during my talk and then starts saying perverted shit like that. Someone’s going to smack him upside the head one day and I surely hope for my sake it’s me.” 

You wrap your arms around his neck, squeezing him twice before letting go. 

“Thank you for that - I was literally going to vomit if I had to room with him.” 

“Well, I told you before. I’m here if you’re uncomfortable.” 

You nod, the two of you walking into the conference room to make edits to your presentation. 

 - 

You and Levi come back to your hotel room after the conference, positively plastered. He’d all but given his talk perfectly and your poster won an award at the end - which meant you and Levi were celebrating well into the night. 

You had your arms slung around each other, your weight uneven, as you both slide back into the hotel room, falling onto the singular bed in the room. You and Levi were greeted with the unpleasant sight earlier in the day - you and Levi both insisting that you would be the ones to sleep on the couch. 

You’re both lying face up on the bed - your cheeks flushed, your chests heaving up and down, the only sound in the room being your shaky breaths. Your hands are still locked together, your brain fuzzy from the events of the night. 

You and Levi amble up after a few minutes, both attempting to change into your pajamas and go to bed. You ogle Levi as he takes his shirt off, watching from the side of the mirror. He catches you, walking closer to you. He still reeks of beer, still shaking on his feet. 

He leans over, pressing his forehead against yours as you hold onto his arms, grounding your fingers into his biceps. He’s still not wearing a shirt, his bare chest on display. You fight the urge to stare at him full on. 

“You’re smart, Y/N.” 

“You’re smart too, Levi.” 

“Did you pay attention during my talk?” 

“Y-yes. You code the information, like a puzzle, to figure out what people’s intentions are.” 

“Hm. You be me. I’ll give you the information and you figure it out, okay?” 

You nod, barely understanding what he was getting at as you lean into him. You can feel the buzz dying down, the tiredness setting into your bones. 

“I’m not a mind reader like you, Levi.” 

“You’ll get this one. You’re my smart girl.” 

He reaches down, securing his hands around your waist as he pulls you closer to him. Your hands and frame are pressed against his chest, his skin cold to the touch.

“You caught my eye on the first day, with your perfectly pressed hair and that stupid black skirt.” 

You can feel your breath catch in your throat, the sound not leaving your throat.

“You take the cubicle two feet down from mine and I can’t help but watch you - reorganize your desk, get up to get water, scribble things on the whiteboard.” 

You can feel his heartbeat get faster against your hear, his grip on your waist tightening. You’re suddenly too aware of what’s happening - Levi, PhD Levi, is shirtless, hugging you in a hotel room. The lights are dim, there’s only one bed, and he’s holding you. 

“I don’t work with other people at the lab, but when you ask, I do. I leave the lab way past the required time, willingly spending more time in a room with that idiot Nile in it just because you’re in it too.”

“Levi.” 

“I’m not done.”

“It drives me crazy, every time Nile talks to you, touches you, looks at you. I want to sock him in the face - because he’s not nearly good enough for you. Not that anyone could be, but for some idiot like that to think he stands a chance is next level infuriating.”

He releases his hands from your face, lifting his hands to cup your face. His touch his soft, his thumb caressing the burning skin on your cheeks as his eyes meet yours.

“I think about you all the time. When I wake up, when I go to sleep, when I eat my breakfast. When I’m not with you, I just want to be around you. And when I’m around you, I want to be with you.” 

He leans forward, pressing a soft kiss to your forehead. His lips are pillowy soft, his breath tickling the edges of your forehead. 

“What does it mean? Figure out my intentions, smart girl.” 

You can feel your entire body burning, your head still spinning - from the alcohol, Levi’s touch, his words ringing in your ears. 

“You…like me.” 

“That’s a fact. Not an intention.” 

“You…want to kiss me?” 

He smiles, leaning forward to press his lips to yours. The kiss is warm, the taste of the beer still hanging on his lips. You can feel his hands moving, carding through your hair as you reach up to press your hand against his shoulders. He kisses you for a long time - your body burning at the entire sensation. He breaks apart, still smiling against your lips. 

“Smart girl.” 

“Do you…remember my research, Levi? From the first day?” 

“I’ve memorized every single thing you’ve ever said to me.” 

You can feel your cheeks flushing, Levi’s hands returning to squish the sides of your face. You grab one of his hands, opening up his fingers and placing it flat against your chest. You move his hand around, until you’re sure he can feel your heart - which is pounding in your chest. 

“Heart rate can give away a great deal. The biomarker can help you understand a lot of different emotions. Figure out which one I’m feeling, Levi.” 

He leans forward, pressing soft kisses all over your face as he starts asking. 

“Anxiety?” - a soft kiss, right on top of your head. 

“No.” 

“Stress?” - a light kiss, right on your closed eyelids. 

“No, Levi.” 

“Companionship.” - a sweet kiss, right on your lips. 

“Yes. But that’s not the one I was looking for.” 

You watch a smirk spread across his face as he leans down, spreading soft kisses all along your neck. He murmurs against your neck, a hint of teasing in his voice. 

“Sexual attraction?” 

“Levi. Quit being a tease.” 

“Shut up, brat.” 

“No. You missed one, Levi.” 

“What was it?” 

“Love. A heartbeat can give away a great deal - can even be used to indicate and understand romantic feelings.” 

He press his hand against your chest again, your heart still hammering. 

“It’s fast. What does that mean?” 

“That I love you.” 

You see a big smile spread across his face, reaching all the way up to his eyes. You see him now and you think it’s the best he’s ever looked - messy black hair, pink cheeks, squinted eyes. He reaches down, opening your fingers and placing them against his bare chest. You can feel his heart hammering in his chest. 

“Fast.” 

“Yeah. Means I love you too, smart girl.” 

- 

[mindblowingscience]

The average glioblastoma patient survives 12-18 months after diagnosis. The crux of the diagnostic is a biochip that uses electrokinetic technology to detect biomarkers, or active Epidermal Growth Factor Receptors (EGFRs), which are overexpressed in certain cancers such as glioblastoma and found in extracellular vesicles. “Extracellular vesicles or exosomes are unique nanoparticles secreted by cells. They are big—10 to 50 times bigger than a molecule—and they have a weak charge. Our technology was specifically designed for these nanoparticles, using their features to our advantage,” says Hsueh-Chia Chang, a professor of chemical and biomolecular engineering at the University of Notre Dame and lead author of the study about the diagnostic published in Communications Biology.

Continue Reading.

[covid-safer-hotties]

Alzheimer's-like brain changes found in long COVID patients - Published Sept 2, 2024

New research from the University of Kentucky's Sanders-Brown Center on Aging shows compelling evidence that the cognitive impairments observed in long COVID patients share striking similarities with those seen in Alzheimer's disease and related dementias.

The study, published in Alzheimer's & Dementia, highlights a potential commonality in brain disorders across these conditions that could pave the way for new avenues in research and treatment.

The study was a global effort, and brought together experts from various fields of neuroscience. Researchers at the UK College of Medicine led the study, including Yang Jiang, Ph.D., professor in the Department of Behavioral Science; Chris Norris, Ph.D., professor in the Department of Pharmacology and Nutritional Sciences; and Bob Sompol, Ph.D., assistant professor in the Department of Pharmacology and Nutritional Sciences. Their work focuses on electrophysiology, neuroinflammation, astrocytes and synaptic functions.

"This project benefited greatly from interdisciplinary collaboration," Jiang said. "We had input from experts, associated with the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART), across six countries, including the U.S., Turkey, Ireland, Italy, Argentina and Chile."

Jiang and the collaborative team focused their work on understanding the "brain fog" that many COVID-19 survivors experience, even months after recovering from the virus. This fog includes memory problems, confusion and difficulty concentrating. According to Jiang, "The slowing and abnormality of intrinsic brain activity in COVID-19 patients resemble those seen in Alzheimer's and related dementias."

This research sheds light on the connection between the two conditions, suggesting that they may share underlying biological mechanisms. Both long COVID and Alzheimer's disease involve neuroinflammation, the activation of brain support cells known as astrocytes and abnormal brain activity. These factors can lead to significant cognitive impairments, making it difficult for patients to think clearly or remember information.

The idea that COVID-19 could lead to Alzheimer's-like brain changes is a significant development.

"People don't usually connect COVID-19 with Alzheimer's disease," Jiang said. "But our review of emerging evidence suggests otherwise."

The research reveals that the cognitive issues caused by COVID-19 reflect similar underlying brain changes as those in dementia. The study's insights emphasize the importance of regular brain function check-ups for these populations, particularly through the use of affordable and accessible tools like electroencephalography (EEG).

The study not only highlights the shared traits between long COVID and Alzheimer's, but also points to the importance of further research.

"The new insight opens avenues for future research and clinical practice, particularly in studying brain oscillations related to neural biomarkers of mild cognitive impairment in people with long COVID," said Jiang.

One of the key findings is the role of astrocytes—support cells in the brain that have not been as thoroughly studied as neurons. The research suggests that damage or activation of these cells by COVID-19 can cause synaptic dysfunctions, leading to the abnormal brain activity observed in both conditions. This discovery is significant because it may help explain why EEG patterns in COVID-19 patients resemble those seen in the early stages of neurodegenerative diseases like Alzheimer's.

Researchers believe this work could have a direct impact on patient care. They are advocating for routine EEG exams to detect early brain changes in both COVID-19 survivors and those at risk for cognitive decline.

"EEG patterns in COVID-19 patients resemble those seen in early neurodegenerative diseases," said Norris.

"These similarities may be due to shared issues such as brain inflammation, astrocyte activity, low oxygen levels and blood vessel damage," said Sompol.

By detecting these changes early, health care providers could potentially identify at-risk individuals sooner and implement interventions to prevent or slow the progression of cognitive decline.

As research continues, the team is particularly interested in how EEG monitoring can predict long-term outcomes in COVID-19 patients and assess the effectiveness of treatments aimed at preventing cognitive decline.

More information: Yang Jiang et al, Parallel electrophysiological abnormalities due to COVID‐19 infection and to Alzheimer's disease and related dementia, Alzheimer's & Dementia (2024). DOI: 10.1002/alz.14089

alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14089