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bowiewashington · 5 months ago

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Drabble: Scenes from a Weekend

Title: Scenes from a Weekend Rating: Mature-ish? Word Count: 2400-ish

Characters: Bennett "Bowie" Washington, Olivia Erwin Washington, Benjamin "Benny" Monroe, Ruth “Bubbe” Goldstein Washington, Ezra Cohen, Kenny the Bodyguard, Daniel Radcliffe (yeah, you read that right), Darlene Cohen, (mentioned), Avery Erwin (mentioned)

Relationships: Bennett "Bowie" Washington/Benjamin "Benny" Monroe (implied), Bennett "Bowie" Washington & Ruth “Bubbe” Goldstein Washington, Bennett "Bowie" Washington & Olivia Erwin Washington, Bennett "Bowie" Washington/Avery Erwin (past)

Triggers: Religion (Judaism), use of a kind of derogatory word for non-Jews, use of Yiddish/Ashkenazi words by reform Jews, references to sex, domestic violence, spousal abuse, emotional abuse, non-consensual free use, victim guilt, child loss, infant loss, over medicating, references to canon underage sex, age difference, #metoo vibes, child marriage/grooming, and a vague reference to a canon suicide attempt.

Notes: So even before the show aired, I told myself that whatever Jonathan Groff won, that’s what Benny would win. Somehow this turned into Merrily We Roll Along being the show Benny was in on Broadway. I have no regrets. Feel free to imagine Benny as Jonathan Groff for now. I have more I want to add, but that’s going to be a next-week project.

Yiddish/Hebrew words: Shabbos - Sabbath, the Jewish day of rest (Friday sundown to Saturday Sundown), also the formal Friday night dinner. Bubbe - grandmother, fondly. Bubeleh - a term of endearment for a grandchild. Goy - a non-Jewish person, can be offensive.

FRIDAY

Friday nights in Brooklyn at Bubbe’s house were always chaotic, and every time Bowie forgot just how popular his grandmother was. She’d owned her apartment in Brooklyn, just outside the Jewish Quarter, for longer than Bowie had been alive. Everyone in the building knew who she was, and he swore everyone stopped by her apartment before going up to the roof for Shabbos. It was making Kenny, the bodyguard that Benny hired for Bowie earlier this year, extremely nervous. Of course, not a single person was paying him any mind.

“A Jewish actor nominated for a Tony dining in Brooklyn?” Bubbe’s neighbor, Gilda, rolled her eyes before shoving a casserole dish into Kenny’s arms. “Throw a rock. You’ll hit another one. Take that to the roof, handsome.”

Kenny shot Bowie a helpless look, and all Bowie could do was laugh, before waving him off. As much as Charlotte was home, so was anywhere Bubbe was living. It definitely felt like home tonight, and for the first time in weeks, Bowie actually felt alive and not like the walking corpse he’d been since the twins were stillborn.

“Bubeleh.” And that was the only warning Bowie got before Bubbe grabbed him by the elbow and guided him over to an older woman and a guy his age who he assumed was her son or grandson. Aw, shit. “There’s someone I want you to meet. This is Peggy, and her grandson, Yoel. This is my Bennett.” She introduced, and fuck. This was definitely a set up. “He’s an actor with his own little show and everything.” Please don’t let her pinch his cheek. “He just got out of a long term relationship, but she was a goy. So she doesn’t count.”

And fucking ouch. “Bubbe, let’s not call Livvie’s mom that. People really don’t use that word any more.” He shot Yoel a small smile. He seemed nice enough, but he also was about Bowie’s age, which meant he could probably chase him off without Benny getting involved. Actually someone must have been distracting Benny because he hadn’t seen him in awhile. “Livvie is my seven year-old.”

Those were the magic words. Almost immediately Yoel and his grandma were moving along to talk to someone else. “Well, I didn’t like him for you anyway.” Bubbe dismissed. “Have you seen your brother? There’s a girl who’s in her last year at Columbia that I want him to meet.”

Happy to pass off her scheming to someone else, he pointed in the last direction he’d seen Ezra in. Almost as soon as she was gone, arms wrapped around his waist. He tensed, until the familiar scent of Benny’s cologne calmed him. With a sigh he relaxed into his ex-husband (partner again?). “What did you say to her during Passover?” He asked. “She’s bolder than normal tonight.”

Benny buried his face against his neck for a moment, just breathing Bowie in. “You’re telling me. She roped little Washington into making me braid her hair over and over. It took me far too long to realize she was purposely distracting me.” He admitted, sounding sheepish.

Well, that answered a couple of questions. “If they really wanted to, I think they could take over the world.” Before Benny could reply, Bowie was dragged off by Olivia to rescue Ezra.

SATURDAY

“Uncle Ez.” Today it was just Bowie, Ezra and Olivia. Well, and Kenny, but he was sitting in the corner while they got manicures and pedicures at the little hole in the wall place Darlene swore by when she lived in Brooklyn. And… okay, Ezra wasn’t getting a manicure. Even though his cuticles were disgusting. “Can I pick the color for your toes?”

A smile worked its way onto Bowie’s face. Much like the night before Bowie was feeling a bit more like himself. He was still in mourning, but he felt like he could breathe. Or maybe it was because he stopped taking the medications his therapist prescribed after the twin’s passing. His head felt clear.

“Is it going to be pink?” Ezra asked skeptically.

Olivia rolled her eyes. “Nooooo.” She drew out the ‘oh’ sound for as long as she could. “BoBo’s letting me pick his colors. No pink for him either.” She giggled as her feet were lifted out of the basin by the nail tech.

“Want to look at colors?” They asked her.

Immediately Olivia looked at him for permission, and wasn’t that something. It made him feel like a dad, which he theoretically knew he was, but it still felt novel every time she did something to remind him. “Go on. I’ll try to talk your uncle into getting his fingers done, too.”

As soon as Olivia was out of earshot, Ezra turned to glare at him. “I thought the whole Ben thing was because of the studio.” He hissed out. “Yeah, I know he’s your longest relationship so there’s that safety and comfort thing, but I didn’t actually think you were back together for real until last night.”

Bowie closed his eyes and leaned his head back against the spa chair. “C’mon, Ez. I thought you were gonna lay off until filming was done.” He whined out. “It’s complicated.”

Ezra glanced around to make sure that Olivia was still out of earshot. “His hand was down your fucking pants. That doesn’t look complicated to me. It looks like you’re screwing your ex again.” And yeah… Ezra was a kid when Bowie and Benny were married, but he saw just how much Benny put him through the first time around.

“We didn’t do anything. I wasn't gonna let him do anything in Bubbe’s bathroom.” He whispered back.

His brother’s eyes narrowed. “And when you’re staying in midtown tomorrow night?” He countered back. “You’re going to let him bend you over the closest surface and fu- FEED you all sorts of different delicious new foods.”

Wait. What? Bowie frowned, but then he saw Olivia bounding over, cradling nail polish bottles in her hands. “I got all sorts of options!”

SUNDAY

Bowie had never actually been to the Tony Awards before. Sure, he’d been to award shows, but he almost felt like he was sitting in tech rehearsals or something. There was a certain vibe in the air. Bowie wasn’t sure if he was excited or if he was going to throw up.

“You okay?” Benny asked him as he gave Bowie’s hand a squeeze as they went down the paparazzi line. And fuck. His brother was right. Sure, he’d announced to the world that he and Benny were back together, but he never actually felt like they were together. Until now. Benny pressed a kiss to Bowie’s knuckles. He’d been obsessed with how soft Bowie's hands were after the manicure. He had no idea what the other man was going to do when he felt his feet.

It was right there, with cameras flashing, that Bowie realized his mistake. He knew Benny was a good shield from people asking probing questions about the loss of his twins, but he didn’t have an exit plan. Now that he wasn’t taking the meds the therapist had prescribed, he realized he’d taken his abuser back. What was that scary statistic Bubbe sent him when someone told her what he’d done? People who went back to their abusers didn’t get out of the relationship alive?

Fuck. He was going to have to actually stay with Benny through filming, and the media shit, too. If he tried to end things with him sooner than that, it was going to cause issues with Death After Life. But if he stayed with him too long… would a repeat of the sex tape happen? How long until Benny started whoring him out again? How long until he tried to convince him to get rid of Olivia? Fuck. He knew he wouldn’t actually hurt Olivia; as long as he could use her to control Bowie.

“I’m fine, baby.” Bowie cooed out when he realized there were cameras on them. He leaned up and pressed a kiss to the corner of Benny’s mouth. “Just a little overwhelmed.”

Benny smiled at him before kissing him properly. “Why don’t you go inside? Go grab some water, and take your anxiety meds. I have to do a couple more interviews.” He suggested.

He forced a smile, and gave him another kiss before disappearing into the Lincoln Center. Instead of taking his meds, he slipped up to the bar and grabbed a whiskey sour. He was three drinks deep, and chatting with some producer Bowie was pretty sure he’d slept with when he was still underage when Benny reappeared.

“You’re not supposed to be drinking on your meds.” He reminded him, stealing his drink.

Bowie rolled his eyes, but nuzzled into him anyway. “I stopped taking them a couple days ago so I could drink tonight.” Sure, he’d been off his meds for a couple of days, but it had been a total accident.

A kiss was pressed to the side of his neck. “That’s my smart boy.”

Seven nominations. Somehow Bowie didn’t realize that Benny’s show had seven nominations. For so long he’d purposely avoided everything Benny related. Now that he was back in his orbit he supposed he should have been paying attention. Seven nominations meant two things: 1) their section was pure chaotic energy and 2) Benny was out of his seat more than he was in it. He couldn’t decide if that was a good thing or not.

As soon as the first award was won by Benny’s co-star, Bowie knew it was going to be a wild night. Even if Benny didn’t win his award, Dan did, which meant they were definitely going to the afterparties. He could feel Benny grip his thigh as Dan thanked him and started crying. Instinctively, Bowie leaned into Benny’s side as his ex-husband sniffled. There was definitely a camera on them, and he knew what it looked like. Darlene was gonna say something when he got back to Charlotte.

Most of the night from there was a blur. Benny had to go backstage for a costume change and to perform. He knew there would likely be a camera on him for his reaction just in case something happened. And sure enough, right there on live television, Benny accidentally sang the not for live TV lyrics to the song they were performing. Bowie felt his hands covering his face, and he knew the slightly time delayed air version would be showing his reaction as the entire line was muted out. And then… he was clapping and cheering as the number finished.

It took awhile before Benny was back in his seat. He pressed a kiss to the side of his head as he slid back into his seat, still slightly sweaty from running around on stage. “You said the wrong liiiine.” He whisper-sang, nudging him. Oh yeah, those drinks had hit him hard.

Benny was laughing into his shoulder, but they didn’t have too much time together before Merrily We Roll Along won Best Revival of a Musical. There was a roar of noise around them, and Benny was kissing him before running up on stage with the rest of the cast. Bowie could feel the fond smile on his face. Fuck. He really was too deep in it now, wasn’t he?

He didn’t have too much time to think about that before Benny was back, and they were reading the nominees for Best Performance by an Actor in a Leading Role in a Musical. The cameras were definitely on them now. As they said his name and showed a clip from Merrily, Benny was holding onto Bowie’s hand, his lips pressed against his knuckles again. And then… then it was pandemonium. Benny won. Benny fucking won. Somehow he was standing and Benny’s arms were around him, and there was a firm kiss pressed to Bowie’s lips and then Benny was off to the stage.

Disconnected from reality. That was the only way Bowie could think to describe how he was feeling, and he wasn’t even the one who won. He watched as Benny stopped to hug Dan on his way to the stage. People were grabbing Bowie’s hands nearby and congratulating him on Benny’s win as the announcer stated that this was Benny’s third nomination but first win. It was bizarre, but then he was being pushed back to sitting, and Benny was at the podium.

“Wow. Uh, okay. Paper, paper.” He was crying as he patted down his pockets for his speech. “Victory!” He straightened out his speech. “Live theater has always been my first love. My second love is sitting over there.” There was laughter and Bowie knew there was a camera on him again. Bowie couldn’t tear his eyes away from Benny. Fuck. He didn’t think he was actually going to win, and now… now whatever Benny said on live television was going to be true. Just like how Bowie blurting out that they were back together when they weren’t had instantly become the truth.

“There are so many people I need to thank, but I’m in disbelief. I remember being eighteen, and telling my brand new costar that I was going to be an EGOT winner one day. Now I just need a Grammy. It blows my mind. And that’s not on my paper.” He shook his head to get back on track. “But I told that same costar I was going to marry him one day, and look at us now.” There was more laughter and then Benny was reading out his list of people to thank. Bowie zoned out for a minute until Benny got to the end. “And last, but definitely never least, Bee. Happy Father’s Day, baby. I know it looks differently than you imagined, but I’m so proud of you for getting out of the house and coming with me tonight. I love you, Bowie Monroe. Everything I do is for you. You make me want to be a better man, a better person. This award is for you.” He blew an air kiss towards Bowie and then he was being escorted off the stage for interviews.

Tears were streaming down Bowie’s face. He fucked up. What had he been thinking? Benny wasn’t going to let him leave again. Bowie had barely got out alive the first time around. Something told him it wasn’t going to be as easy this time.

#drabble #queen city rpg

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brookstonalmanac · 6 months ago

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Birthdays 5.30

Beer Birthdays

Peter Schemm (1824)

Adolph G. Bechaud (1840)

John Gilroy (1898)

Candy Lightner (1946)

Adam Avery (1966)

Ben Love (1978)

Five Favorite Birthdays

Mikhail Bakunin; political philosopher (1814)

Mel Blanc; voice actor (1908)

Benny Goodman; jazz clarinetist (1909)

Shauna Grant; porn actor, a.k.a. Colleen Applegate (1963)

Howard Hawks; film director (1896)

Famous Birthdays

Alexander Archipenkpo; sculptor (1887)

King Arthur; legendary British leader (c. late 5th century)

Julius Axelrod; biochemist (1912)

Hal Clement; writer (1922)

Countee Cullen; poet (1903)

Arthur Vining Davis; businessman, philanthropist (1867)

Keir Dullea; actor (1936)

Kevin Eastman; comic book artist (1962)

Jennifer Ellison; model, actor (1983)

Pee Wee Erwin; jass trumpeter (1913)

Bob Evans; sausage-maker, restaurateur (1918)

Peter Carl Faberge; jeweler, goldsmith, egg-maker (1846)

Stepin Fetchit; actor (1902)

Hugh Griffith; actor (1912)

Topper Headon; rock drummer (1955)

Wynonna Judd; country singer (1964)

Seton Howard Frederick Lloyd; archeologist (1902)

Meredith MacRae; actor (1944)

Ted McGinley; actor (1958)

Tom Morello; rock guitarist, singer (1964)

Alexander Nevski; Russian leader (122)

Peter the Great; Russian tsar (1672)

Michael J. Pollard; actor (1939)

Robert Ryman; artist (1930)

Gale Sayers; Chicago Bears RB (1943)

Cornelia Otis Skinner; actor, writer (1901)

Joseph Stein; playwright (1912)

Harry Clement Stubbs; writer (1922)

Irving Thalberg; film director (1899)

Stephen Tobolowsky; actor (1951)

Frankie Trumbauer; jazz saxophonist (1901)

Louis Varney; composer (1844)

Clint Walker; actor (1927)

#Birthdays

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scrutonworld · 8 months ago

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Isaac Erwin Avery writes “He becomes dazed by the glare and glitter, the big sounds and the mad tumult, and calls all this a part of seeing and learning and living and broadening … He is a drop of oil in a mammoth machine, or--to change the figure-- he reminds one of a bit of scurrying chaff in a maelstrom.”

“The Simple Life.” By Isaac Erwin Avery. From Moonshine and Magnolias.

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rp-oc-bs · 1 year ago

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A thing

Emma Molloy’s related people

Milly Shapiro

Miranda Lambert

Lucy Molloy

Abigail Shapiro

Carrie Underwood

Violet Wakeman

Emma Howard

Cassie Levy/Joanna Christie (Katie); daughter named Oona Nora with boyfriend Jeff Summers (Kai)

Cait Fairbanks (Christy)

Logan & Nora Wakeman - Christy & Kai

Gabriel Egbert & Jill Paice

Seth Monroe

Jack Broderick (Christy)

Santino Fontana (Kai)

Kendra Monroe - Kai

Analise Scarpaci

Annabelle Madden - Christy

Ava DeMary

Laura Osnes

Shiane Parkington / Ramsey - Katie

Beatrice Tulchin

Phillipa Soo

Charlotte Daaé

Oona Laurence

Samantha Hill (Katie)

Christine Dwyer (Kai)

Anjuli Kaur - Katie

Frenie Acoba

Aurora Hamilton / de Chagny - ???

Anna Kendrick

Melissa Frost - Christy

Bailey Ryon

Amelia St Clair

Sophia Gunnusa

Leonardo Ethernington - Kai

???

Natasha Alkaev/Ethernington - Katie

Jeanna de Waal

Hailey Leo - Kai

???

Hamlet Madden - Christy

???

Nathan Johnson

Kat Schwartz (m) - Kai

Marcus D’Angelo (child)

?? (adult)

Hayden Whittaker’s related people

John Lloyd Young

Charlotte Daaé - Katie

Oona Laurence

Samantha Hill

Allegra McKenna - Katie

Erin Mackey

Devonny Hamilton - Katie

Hayley Westenra

(Devonny Hamilton DeRouen de Chagny)

Dimitri Saylor

Jarrod Spector

Andy Jay Matthews

Shonn Wiley

Zachary Davison

Erich Bergen

Carson Spencer’s related people

Corey Cott

Ellie McDaniel - Katie

Kara Lindsay

Jeremy Wakeman - Christy?

Andrew Keenan-Bolger

Irena Klein - Katie

Laura Osnes

Katherine Erwin - Katie

Hannah Elless

Amanda Wells’ related people

Lisa O’Hare

Ariana Wakeman - Kai

Lauren Worsham

Dustin Wind - Christy

Bryce Pinkham

Autumn Wadsworth - Christy

Catherine Walker

Emily Webster

Kristen Beth Williams

Misc people, different full name

Joshua Abram Hoff

Matthew Hydzik

Alix Heisburg - Katie

Autumn Hurlbert

Timothy Andersen

Wesley Taylor

Athena Gomez - Avery

Krysta Rodriguez

Ellie Wilson - Avery

Sandra Mae Frank

Elijah Marlow

Kevin Massey

Samantha Underwood

Alex Caldwell

Megan Kaufman

Veronica J Kuehn

Adrian Gardiner

Reeve Carney

Lillian Bishop-Levitt - ???

Annika Larsen

Charissa Hogeland

Adrian Blakeney - Katie

Carrie Hope Fletcher

Penelope Bernardi - Avery

Jennifer Damiano

Emi Hashimoto

Yuga Yamato

Sylvia Morris

Ruby Lewis

Ariana Wakeman - Kai

Gabriella Pizzolo

Lauren Worsham

Josiane Richard - ???

Kara Lindsay

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brookston · 1 year ago

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Holidays 7.18

Holidays

Anti-Bigot Day

Billy Joel Day (New York)

Chrysanthemum Day

Constitution Day (Uruguay)

Hug a Fat Bald Person Day

Insurance Nerd Day

International Laquita Marina Day

Jane Austen Day (Indiana)

Lollapalooza Day

Make A List of the People You Love Day

National Brenda Day

National Hamiltons Day

National Dapper Your Data Day

National Monica Day

National Mortgage Brokers Day

National Peyton Day

Nelson Mandela Day (a.k.a. Mandela Day; UN)

Perfect Family Day

Perfect 10 Day

President’s Day (Botswana)

Pyramids Day

718 Day (New York)

Shawm Day (French Republic)

Tony the Tiger Day

Weinermobile Day

World Listening Day

Food & Drink Celebrations

International Brewers Day

National Caviar Day

National Sour Candy Day

St. Anou, Bishop of Metz's Day (patron saint of brewers; a.k.a. St. Arnulf, Arnould, St. Arnold)

3rd Tuesday in July

National Children’s Book Day (Philippines) [3rd Tuesday]

Independence Days

Prsänëa (Declared; 2012) [unrecognized]

Feast Days

Arnulf of Metz (Christian; Saint) [brewers] *

Bobby Henderson Day (Pastafarian)

Bruno of Segni (Christian; Saint)

Camillus de Lellis (optional memorial, U.S. only)

Eadburh (a.k.a. Edburga) of Bicester (Christian; Saint)

Eid-e-Ghadir (Iran)

Elizabeth Ferard (Church of England)

Feast of Saint Arnoldus (Belgium)

Feast of Teneu

Frederick of Utrecht (Christian; Saint)

Hyacinthe Rigaud (Artology)

Leroy (Muppetism)

Marina of Aguas Santas (Christian; Saint)

Maternus of Milan (Christian; Saint)

Nebet-Het (Birthday of Nephthys, Egyptian Goddess of Beer)

Nephthy’s Day (Pagan)

Odulph (Christian; Saint)

Pambo (Christian; Saint)

Philastrius (Christian; Saint)

Rabelais (Positivist; Saint)

Symphorosa (Christian; Saint)

Theneva (Christian; Saint)

Theodosia of Constantinople (Christian; Saint)

Thomas Morton Day (Church of the SubGenius; Saint)

Vitulatio (Feast to Vitulatio, Ancient Roman Goddess of Exultation, joy & life)

Water Pistol Day (Pastafarian)

Lucky & Unlucky Days

Day of Bad Omens (Ancient Rome) [1 of 2]

Prime Number Day: 199 [46 of 72]

Shakku (赤口 Japan) [Bad luck all day, except at noon.]

Unfortunate Day (Pagan) [41 of 57]

Premieres

Aliens (Film; 1986)

Arachnophobia (Film; 1990)

Bad Boys II (Film; 2003)

Bosko’s Holiday (WB LT Cartoon; 1931)

Closer, by Joy Division (Album; 1980)

Consider the Oyster, by M.F.K. Fisher (Food Essays; 1941)

Davy Crockett and the River Pirates (Film; 1956)

The Dark Knight (Film; 2008)

Entourage (TV Series; 2004)

Eureka (TV Series; 2006)

Friends with Benefits (Film; 2011)

George of the Jungle (Film; 1997)

God Only Knows, by The Beach Boys (Song; 1966)

I Love to Sings (WB MM Cartoon; 1936)

Johnny English (Film; 2003)

Jurassic Park III (Film; 2001)

Mamma Mia! (Film; 2008)

Mrs. Brown (Film; 1997)

The Nun’s Story (Film; 1959)

Planes: Fire & Rescue (Animated Film; 2014)

Porco Rosso (Studio Ghibli Animated Film; 1992)

RWBY (Anime Series; 2013)

Sex Tape (Film; 2014)

Sketches of Spain, by Miles Davis (Album; 1960)

Tweet and Lovely (WB MM Cartoon; 1959)

UHF, by Weird Al Yankpvic (Soundtrack Album; 1989)

Used Cars (Film; 1980)

Wouldn’t It Be Nice, by The Beach Boys (Song; 1966)

Today’s Name Days

Answer, Arnold, Arnulf, Friedrich, Ulf (Austria)

Emil, Emilian (Bulgaria)

Bruno, Emilija, Frederik, Ljuba (Croatia)

Drahomíra (Czech Republic)

Arnolphus (Denmark)

Eerika, Erika (Estonia)

Riikka (Finland)

Frédéric (France)

Arnulf, Friedrich, Ulf (Germany)

Aimilianos, Emilianos (Greece)

Frigyes (Hungary)

Calogero, Giusta (Italy)

Rozālija, Roze, Rozīte (Latvia)

Eimantė, Ervinas, Kamilis, Tautvilas (Lithuania)

Arnulf, Ørnulf (Norway)

Arnold, Arnolf, Erwin, Erwina, Kamil, Karolina, Robert, Roberta, Szymon, Unisław, Wespazjan (Poland)

Anna (Russia)

Kamila (Slovakia)

Federico, Marina (Spain)

Fredrik, Fritz (Sweden)

Alfie, Alfred, Avery, Federica, Federico, Fred, Freda, Freddie, Freddy, Fréddy , Freed, Frederic, Frédéric, Frederich, Federik, Frederick, Frédérick, Frederico, Fredrick, Fredy (Universal)

Fred, Freda, Freddie, Freddy, Frederica, Frederick, Frederico, Fredrick, Fredy (USA)

Today is Also…

Day of Year: Day 199 of 2024; 166 days remaining in the year

ISO: Day 2 of week 29 of 2023

Celtic Tree Calendar: Tinne (Holly) [Day 9 of 28]

Chinese: Month 6 (Ji-Wei), Day 1 (Ding-Chou)

Chinese Year of the: Rabbit 4721 (until February 10, 2024)

Hebrew: 29 Tammuz 5783

Islamic: 29 Dhu al-Hijjah 1444

J Cal: 19 Lux; Fiveday [19 of 30]

Julian: 5 July 2023

Moon: 1%: Waxing Crescent

Positivist: 3 Dante (8th Month) [Rabelais]

Runic Half Month: Ur (Primal Strength) [Day 5 of 15]

Season: Summer (Day 28 of 94)

Zodiac: Cancer (Day 28 of 31)

Calendar Changes

荷月 [Héyuè] (Chinese Lunisolar Calendar) [Month 6 of 13] (Lotus Month)

#calendar #Holidays

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scienza-magia · 2 years ago

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Nel 1953 veniva scoperto "Il segreto della vita"

70 anni fa scoprivamo la struttura del dna: ecco come ci ha cambiato la vita. Ripercorriamo le tappe che hanno preceduto questo importante risultato e il modo in cui ha rivoluzionato il futuro della genetica con l’aiuto dello storico della medicina. La scoperta della struttura del dna ha 70 anni. Il 28 febbraio 1953 è passato alla storia come il giorno in cui un inglese e un americano entrarono in un pub e annunciarono di aver risolto un enigma su cui buona parte della comunità scientifica dell’epoca si scervellava ormai da decenni. I due uomini in questione erano naturalmente James D. Watson e Francis Crick e la scoperta a cui si riferivano riguardava nientemeno che “il segreto della vita”. Erano più di cinquant’anni che medici, fisici e biologi si interrogavano riguardo l’esistenza e la natura dei geni. Perciò, quando i due studiosi avanzarono una teoria che contemplava un codice della vita basato su un “alfabeto” di quattro “lettere” disposte in una struttura a doppia elica (scoperta che valse loro e al fisico Maurice Wilkins il premio Nobel per la medicina nel 1962), si posero le basi per una vera e propria rivoluzione copernicana nel campo della biologia e per un cambio di paradigma che avrebbe orientato il futuro della ricerca biomedica, aprendo la strada a possibilità di intervento terapeutico fino ad allora impensabili. I passi della scoperta La scoperta del Dna ha 70 anni e noi ripercorriamo le principali tappe che hanno preceduto e reso possibile questo risultato e il modo in cui esso ha cambiato la storia della medicina insieme ad Andrea Grignolio, docente di storia della medicina presso l’Università Vita-Salute S. Raffaele di Milano e di bioetica presso il Cnr, Centro Interdipartimentale per l’Etica e l’Integrità nella Ricerca CID-Ethics. “All’inizio del Novecento vennero riscoperte le leggi di Mendel sull'ereditarietà dei caratteri e la comunità scientifica iniziò perciò a interrogarsi sulla natura del gene e, eventualmente, su quale fosse il suo sostrato chimico”, racconta Grignolio. “Nei primi anni del secolo scorso vennero condotti, in particolare, due importanti esperimenti che indirizzarono biologi, medici e chimici nella giusta direzione. Il primo fu quello del biologo Thomas Hunt Morgan che grazie allo studio della drosofila (il moscerino della frutta) dimostrò come i geni fossero disposti sui cromosomi; il secondo fu quello di Hermann J. Muller, che scoprì che l’esposizione ai raggi X aumentava il tasso di mutazione di alcune cellule riproduttive”. Nonostante questo, fino all’inizio degli anni Cinquanta, ovvero pochissimo tempo prima della scoperta di Watson e Crick, ancora si discuteva per capire se i geni fossero composti dalle proteine o dagli acidi nucleici (come di fatto è, ndr). Com’era già noto allora, i “mattoni” che formano le proteine, ovvero gli aminoacidi, sono di venti tipi differenti, al contrario degli acidi nucleici, che sono costituiti dalla combinazione di sole quattro basi azotate. In altre parole, un alfabeto di venti lettere sembrava più adatto a codificare progetti di sviluppo di interi organismi complessi, rispetto a uno di quattro. I momenti chiave Per dirimere la questione fu rilevante l’esperimento di Avery del 1944. Il medico canadese Oswald T. Avery intervenne su alcune cellule infettate dal batterio dello pneumococco privandone alcune delle proteine, altre dei polisaccaridi, e altre del dna. Appurò quindi che fosse quest’ultimo a detenere la capacità che lui chiamò “principio trasformante”, ovvero quella di ricevere il materiale genetico proveniente dal batterio. Infatti, solo nelle cavie le cui cellule ancora contenevano dna e rna avveniva il contagio veicolato dal batterio. Dopo pochi anni, nel 1950, il celebre biochimico austriaco Erwin Chargaff condusse alcuni esperimenti che dimostrarono che il rapporto tra le quattro basi azotate che compongono il dna fosse molto più sofisticato di quanto sembrasse. Scoprì infatti che in ogni molecola di dna il numero di basi A (Adenina) corrispondeva a quello del numero di basi T (Timina) e che il numero di basi C (Citosina) corrispondeva a quello delle basi G (Guanina), nonché che la composizione in basi del DNA variava da una specie all'altra e non era modificata in base all'età. Alcuni conclusero che le 4 basi potessero costruire un “codice” con le istruzioni necessarie per portare le informazioni genetiche”. Parallelamente a tutte queste ricerche condotte nell’ambito della biologia, traguardi altrettanto importanti furono raggiunti grazie al lavoro dei fisici, che a partire dagli anni Trenta contribuirono a gettare le prime basi per lo studio della biologia molecolare. “Uno dei protagonisti di questo filone di studi fu il fisico austriaco Erwin Schrödinger che nel 1944 scrisse What is life, il primo best seller della biologia molecolare”, prosegue Grignolio. “In quest’opera Schrödinger ipotizzava, in maniera geniale, che il gene assomigliasse a un “cristallo aperiodico”, la cui struttura chimica doveva essere molto stabile (proprio come quella di un cristallo) ma allo stesso tempo irregolare, e che contenesse al suo interno una sorta di “codice morse” composto di pochissimi elementi di base in grado però, combinandosi, di trasmettere molte informazioni”. La svolta (e una grossa scorrettezza) E arriviamo così a Watson e Crick. “Negli anni Cinquanta in Inghilterra vi erano due laboratori in cui si lavorava con la spettroscopia a raggi X, una tecnologia sviluppata durante la rivoluzione industriale per analizzare i tessuti artificiali e successivamente applicata all’indagine della materia vivente”, spiega Grignolio. “Il primo era quello del King's College di Londra, dove sotto la direzione di Maurice Wilkins lavorava anche Rosalind Franklin, la chimica che per prima sarebbe riuscita a fotografare con precisione una molecola di dna; l’altro era il Cavendish laboratory dell’università di Cambridge. Fu qui che si incontrarono e iniziarono a collaborare James D. Watson, che si era da poco trasferito dal King’s College – continuando le sue ricerche di dottorato dirette dal medico e genetista italiano Salvatore Luria – e Francis Crick”. Watson e Crick si misero al lavoro per cercare di mettere insieme, come i pezzi di un puzzle, tutti quei risultati scientifici cui abbiamo accennato e che erano stati acquisiti nel corso degli ultimi decenni in ambiti di ricerca differenti. È interessante ricordare che i due studiosi riuscirono a costruire il loro modello sulla struttura del dna senza condurre alcun esperimento. Ciò non toglie nulla alla loro genialità, che permise loro di unire tutte quelle informazioni “sparse” in un’unica teoria coerente”. Va anche ricordato, però, che la conferma definitiva della loro teoria avvenne in seguito a una delle più famose scorrettezze ai danni di una donna nella storia della scienza. Fu infatti Wilkins a rubare a Franklin la celebre fotografia 51, in cui la chimica era riuscita a immortalare una molecola di dna di cui era possibile distinguere la struttura a doppia elica, e a mostrarla a Watson. “La mossa di Wilkins fu certamente scorretta”, commenta Grignolio “e altrettanto sbagliato fu non riconoscere fin da subito a Franklin il dovuto merito per il suo lavoro – ciò invece avvenne solo dopo il 1968, grazie al racconto autobiografico della scoperta da parte di Watson con il suo best seller La doppia elica. Detto ciò, va comunque rimarcato che la fotografia in questione, la famosa 51, fu senza dubbio molto utile, ma comunque non essenziale alla scoperta di Watson e Crick, i quali, oltre alla foto, raccolsero e riordinarono i risultati tratti da almeno altre otto ricerche per completare quel rebus”. Nell’articolo che pubblicarono su Nature il 25 aprile del 1953 per comunicare la loro scoperta, Watson e Crick avanzarono, con una elegante frase tipica dell’understatement britannico (“Non è sfuggito alla nostra attenzione”) anche l’ipotesi che l'alternanza delle basi azotate probabilmente nascondesse la complessità dell’informazione genetica. Questo, però, fu dimostrato in seguito: fu infatti nel 1961 che i biochimici Marshall W. Nirenberg e J. Heinrich Matthaei scoprirono l’esistenza dei codoni, ovvero di quelle triplette di basi azotate che codificano i diversi aminoacidi. Le basi per il nostro futuro Nei decenni successivi, la scoperta del codice genetico, identico dalle drosofile sino ad Einstein, ha permesso l’esplosione della biologia molecolare e anche dell’ingegneria genetica. Quando infatti venne scoperta all’inizio degli anni Settanta l’esistenza degli enzimi di restrizione, capaci di tagliare e sostituire pezzetti di dna, si iniziò a discutere della possibilità di intervenire sul genoma umano per alterare artificialmente la trasmissione dell’informazione genetica. Per la prima volta nella storia si apriva per gli esseri umani la possibilità di modificare a proprio piacimento il piano di sviluppo di un organismo vivente e nel 1975, durante la Conferenza di Asilomar, la comunità scientifica si ritrovò per discutere i possibili pericoli e le sfide etiche che si prospettavano all’orizzonte. Oltre ai pericoli derivanti dalle possibilità di applicazione dell’ingegneria genetica, fu presto chiaro anche il potenziale terapeutico di una tecnologia in grado di manipolare il dna. “All’epoca era già ben nota l’esistenza di quelli che il medico ottocentesco Archibald Garrod aveva definito inborn errors (“problemi congeniti”), ovvero di determinate malattie ereditarie la cui frequenza familiare non poteva essere altro che genetica”, ricorda Grignolio. “Nel 1949 la scoperta delle basi genetico-molecolari dell’anemia falciforme da parte di Linus Pauling, premio Nobel per la chimica nel 1954, lasciò intuire che l’individuazione delle cause genetiche delle malattie ereditarie avrebbe permesso, in futuro, di applicare l’ingegneria genetica a fini terapeutici per cercare di correggere a monte le mutazioni del dna associate all’insorgenza di alcune patologie. Diverse scoperte successive confermarono questa idea che a metà anni Ottanta prese il nome di Progetto genoma umano, il cui ambizioso obiettivo era quello di mappare l’intero codice genetico degli esseri umani per cercare di individuare e di eliminare i geni difettosi e di comprendere i maccanismi di molte altre malattie, tra cui il cancro. Non a caso, con un celebre articolo del 1986 su Science, uno dei promotori del Progetto genoma umano fu l’italiano Renato Dulbecco, premio Nobel nel 1975 per gli studi sugli oncogeni. “Come sappiamo, ci sono voluti quindici anni per portare a termine la prima fase dell’impresa, ma il sequenziamento del genoma umano ha consentito, negli ultimi decenni, lo sviluppo delle più avanzate terapie geniche, cellulari e tissutali (specialmente quelle a base di cellule staminali) attualmente disponibili. Grazie ad esse è oggi possibile trattare malattie che fino a pochi anni fa erano incurabili, come molti tumori del sangue infantili e malattie genetiche, e ricostruire e rigenerare interi tessuti in pazienti in vita”. Read the full article

#cellulestaminali #Dna #doppiaelica #genetica #GenomaUmano #raggix #terapiegeniche

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spiderandthesims · 3 years ago

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1880s Names

Boys

Abel, Abraham, Adam, Addison, Adelbert, Alexander, Alfred, Aloysius, Alphonse, Ambrose, Amos, Anderson, Andrew, Angus, Anthony, Anton, Archibald, Art, Arthur, Aubrey, August, Augustine, Augustus, Avery

Girls

Ada, Adelaide, Adele, Adeline, Agatha, Agnes, Alice, Alma, Almeda, Alta, Anastasia, Angeline, Anna, Annabelle, Anne, Arizona, Augusta, Augustine, Aurelia, Aurora

Boys

Barney, Benjamin, Bennett, Bernard, Bishop, Bradford

Girls

Beatrice, Bernadette, Bess, Bessie, Beulah, Birdie

Boys

Carlton, Carson, Casper, Cassius, Cecil, Charles, Chauncey, Chester, Christian, Christopher, Clarence, Claude, Clement, Clifford, Coleman, Conrad, Cornelius, Curtis

Girls

Camille, Caroline, Catherine, Cecilia, Celestia, Celestine, Celia, Charity, Charlotte, Christine, Claire, Clara, Clarice, Claudia, Clementine, Conception, Constance, Corda, Cordelia, Cornelia

Boys

Dallas, Daniel, Darius, David, Dennis, Dewitt, Dorsey, Douglas, Dudley, Dwight

Girls

Daisy, Delia, Della, Delphia, Docia, Dollie, Dolly, Dolores, Dora, Dorcas, Doris, Dorothy, Dove, Dovie, Drucilla

Boys

Early, Edmond, Edward, Edwin, Eldridge, Eli, Elias, Elijah, Elliott, Ellis, Ellsworth, Elmer, Elton, Elwood, Emerson, Emery, Emil, Emmett, Enoch, Ephraim, Erasmus, Erastus ,Eric, Ernest, Ervin, Erwin, Eugene, Everett, Ezra

Girls

Edith, Edmonia, Effie, Elaine, Elda, Eldora, Eleanor, Elise, Eliza, Elizabeth, Ella, Elma, Elnora, Eloise, Elsa, Elsie, Emily, Emma, Emmaline, Era, Erma, Erna, Ernestine, Essie, Esta, Estella, Estelle, Esther, Ethel, Ethelyn, Etta, Eudora, Eugenia, Eula, Eulalia, Eunice, Euphemia

Boys

Felix, Ferdinand, Francis, Franklin, Frederick, Fredrick

Girls

Fanny, Fay, Felicia, Fern, Fidelia, Flora, Florence, Florida, Francis

Boys

Gabriel, Garrett, General, George, Gideon, Giles, Golden, Gregory

Girls

Geneva, Genevieve, Georgia, Georgie, Goldie, Grace, Gwendolyn

Boys

Harmon, Harold, Harris, Harrison, Henry, Hollis, Homer, Horace, Howard, Howard, Howell, Hugo

Girls

Harriett, Hattie, Henrietta, Hester, Honora, Hope, Hortense

Boys

Irving

Girls

Imogene, Indiana, Iona, Iris, Isadora

Boys

Jack, Jackson, Jacob, James, Jasper, Jeremiah, John, Jonathan, Joseph, Josiah, Judson, Jules, Julian, Junius

Girls

Jane, Josephine, Judith, Julia, Julie, Juliet, June

Boys

Kenneth

Girls

Kathleen

Boys

Lawrence, Lawson, Leander, Leonard, Lewis, Lionel, Logan, Lucien, Lucius, Luther, Lyman

Girls

Lacy, Lillian, Lilly, Louise, Lucia, Lucille, Lucinda, Lucretia, Lucy

Boys

Major, Malcolm, Marcus, Marshall, Martin, Mason, Mathias, Matthew, Maurice, Maxwell, Michael, Miles, Milo, Milton, Monroe, Morgan, Mortimer

Girls

Mabel, Madeline, Magnolia, Marie, Mary, Matilda, Maude, May, Melinda, Mildred, Millicent, Millie, Minerva, Minnie, Miriam, Missouri, Mollie, Mona

Boys

Nathan, Nathaniel, Neil, Nelson, Newton, Nicholas, Noah, Noel, Norman, Norris

Girls

Netta, Nettie, Nevada, Nona, Nora, Norah, Norma

Boys

Oliver, Oren, Orson, Otis, Otto, Owen

Girls

Odelia, Odessa, Ola, Olive, Ona, Opal, Ophelia, Ora, Orpha, Ottilie

Boys

Patrick, Percival, Percy, Peter, Phillip, Pierce, Pleasant

Girls

Pansy, Parthenia, Patience, Pearl, Penelope, Permelia, Philomena, Phoebe, Polly, Priscilla, Prudence

Boys

Quincy

Boys

Raymond, Richard, Richmond, Robert, Rodney, Roger, Ross

Girls

Rita, Rosalie, Rose, Rowena, Ruby, Ruth

Boys

Samuel, Seymore, Sidney, Silas, Simon, Solomon, Stanley, Stephan, Sterling, Stewart, Sylvester

Girls

Samantha, Sophronia

Boys

Thaddeus, Theodore, Thomas, Thorton, Tillman, Timothy, Tobias, Truman

Girls

Tennessee, Thelma, Theodora, Theodosia, Theresa, Tillie

Boys

Ulysses

Girls

Una

Boys

Valentine, Vernon, Victor, Vincent, Virgil

Girls

Vera, Verona, Vesta, Victoria, Viola, Violet, Virginia, Vivian

Boys

Walker, Wallace, Walter, Warren, Watson, Webster, Wesley, Wilber, Wilbert, Wilbur, Wiley, Wilfred, Willam, Willard, William, Wilson, Winfield

Girls

Wilda, Wilhelmina, Wilma, Winifred, Winnifred, Winona

Girls

Zella, Zora

#1880s #baby names #sims 4 decades challenge #ts4 historical #This is part one of a series of posts #if you have trouble naming sims especially for the decade and historical challenges feel free to use this as a resource #i went thru the top 1000 names of the 1880s in the ssa name census and picked the ones i liked and hated the least lol #txt

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