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uncloseted · 5 years ago

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Advice for taking MDMA the first time

First things first, I want to make it clear that I’m not advocating doing drugs, but I also understand that people are curious about them and I’d rather you have the information necessary to make better choices if you do decide to try them. So many drug-related deaths are the result of misinformation, and I think it’s important to change that as much as possible. So that’s where I’m coming from in answering this question.

Also, I want to say that there’s a difference between doing drugs for fun/because you’re curious and doing drugs because you feel like they help you deal with/escape the problems in your life. Regardless of the drug, if you’re doing it because of problems in your life, you’re at a much higher risk for addiction than people who are doing it recreationally. I think it’s really important to assess your motivations and make sure that you’re not looking for a “feel better fast” fix to the difficulties of life. I know it can seem like it’s not a big deal to escape your problems for a little bit, or that it will be fine if you do it just once, but in that type of scenario, it’s very rarely just once. This is a really big factor in the opioid epidemic in the US right now, so I think it’s important to talk about. If you’re struggling with your life, talking to a therapist is a much better, safer, effective option. In the wise words of Riley from Sense8, "It's not the drugs that make a drug addict, it's the need to escape reality."

Additionally, it’s important think about your behavior- are you someone who’s obsessive in other areas of your life? If you find yourself engaging in perfectionistic, compulsive, or addictive behaviors when it comes to other things (school/work, video games, food, caffeine), you may need to be careful when it comes to drug usage. The more we learn about addiction, the more it seems like a certain percentage of people are just predisposed to being addicts and will develop those behaviors regardless of what the behavior is directed at. If you think you might have that type of personality, it’s important to approach drugs with caution, if at all, and to avoid ones that are commonly causes for addiction.

Now that’s out of the way, here are some general harm reduction techniques you should always practice when you’re doing drugs:

- Know what you’re getting. Some drugs look like one thing but turn out to be another or turn out to be laced with something else. You can get testing kits online that can help you figure out if the drug you were sold is what you think it is or not.

- Have a sober companion. Having someone around who’s in a sober state can help to prevent anything really bad from happening.

- Don’t mix. Combining drugs can increase risk to your system, and so can mixing drugs with alcohol. In this case, “combining” is taking any drug/medication/alcohol up to 24 hours before another drug. This includes any prescription medication you might be taking. SSRIs, anti-depressants, and anti-anxiety medications commonly have interactions with other drugs, so you have to be careful. It also includes any supplements you might take.

- Go slow and know your dose. Make sure to research the correct dosing for any drug you might be thinking about taking, and then take less of it than is recommended. You can always take more if you’re not feeling an effect, but you can’t take less. Also make sure that you’re taking the right dose for you. Body weight, height, and gender can impact how drugs are metabolized in our systems, and so what works for your friend may be too much for you (although some drugs, like hallucinogens, are not weight dependent). Don’t try to compete with other people to see who can do the most. Along with that, it’s important to know how long the drug takes to “hit”. Sometimes people fall into the trap of waiting a few minutes, deciding the dose they took isn’t going to do anything, and then take more, which results in them having too much of the drug in their system. Again, it’s important to go slow. Take more time than you think you might need before taking another dose.

- Write everything you’ve taken down and never lie to paramedics. In the event that things do go south, you want to be able to tell the paramedics everything you’ve taken, in what doses, and how long ago so that they can treat you. Paramedics will not report you to the authorities for taking illegal drugs; they just want to treat you. If you’re ever in a situation where someone is having a bad reaction to a drug or overdosing, call the paramedics. You won’t get in trouble and you can save a life.

- Do it somewhere safe, and give yourself time. Preferably in a house, without a ton of dangerous items around, where you are unlikely to encounter the police or disapproving adults. Whether or not you agree with it, in most countries doing drugs is illegal, and you don’t want a court case on your hands. Drug addiction ruins lives, but so does being arrested for drug possession (in the US, at least), and being arrested happens more frequently. You also want this environment to be one in which you feel relaxed and where nothing disturbing or scary is likely to happen. You also want to make sure that there are no time pressures on you for more than the duration of the drug- clear at least your entire day just in case.

Onto MDMA specifically, MDMA is pretty low risk, although not entirely risk free. Here’s what you need to know: “ecstasy” is a drug that’s very commonly not actually MDMA, so it’s really important to make sure you know what you’re getting. PMA, which is often passed off as MDMA or ecstasy, takes longer to kick in and so has a higher risk of overdose. MDMA has a lag time from about 20 minutes to an hour before the effects kick in, and the effects peak about 2 hours after the pill is swallowed. Other drugs being passed off as MDMA may take longer, so wait at least an hour before deciding it didn’t work, and don’t take more. With MDMA, one of the most common issues is overheating or dehydration. Make sure that you’re drinking plenty of water or a sports drink, but also that you’re regularly going to the bathroom, since MDMA can stop you from urinating. It’s a good idea to avoid anything that might make you more dehydrated, like alcohol. A guideline is to drink up to 1 cup per hour (250 ml) of electrolyte containing fluids, or up to 2 cups (500 ml) if you are dancing or in a hot environment. Popsicles are also excellent for this, since they’re mostly water but also help the oral fixation some people get when they’re on MDMA.

If you’re taking an SSRI or herbal supplements that impact serotonin levels (such as HTP-5 or St John’s Wort), MDMA is one to skip. Taking MDMA alongside a serotonin increasing drug can result in serotonin syndrome, which is potentially fatal. This also goes for people taking MAOIs (or if you’ve stopped taking MAOIs within the last three weeks). You should also skip MDMA if you have a history of heart problems, including tachycardia or a-fib, liver problems, kidney problems, problems regulating body temperature, or susceptibility to seizures.

You may experience an MDMA “hangover” the next day, where your serotonin is depleted and you feel depressed. This is normal and will wear off, but if you have a history of depression, that may be something to consider. Like with other drugs, don’t mix MDMA with anything, but especially avoid mixing MDMA with caffeine, alcohol, amphetamines, cocaine, and anything else that may raise your heart rate (asthma medications, Robitussin, stomach acid medications). Watch out for symptoms of heatstroke, such as feeling anxious, very restless, really hot, confused or being unable to communicate clearly. For best results, wait 2-3 months between taking MDMA.

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your-dietician · 3 years ago

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Does It Have an Effect?

New Post has been published on https://depression-md.com/does-it-have-an-effect/

Does It Have an Effect?

High blood pressure, or hypertension, can lead to serious health concerns like a heart attack or stroke. But because hypertension doesn’t typically cause symptoms, many people who have it don’t even know. That’s why it’s so important to regularly check your blood pressure.

If you have hypertension, you may have heard that cannabidiol (CBD) can help lower blood pressure. Here’s what the research says, plus tips for finding a few products to explore.

Blood pressure is defined as the pressure of blood against the walls of the arteries. While it’s normal for blood pressure rates to rise and fall over the course of a day, consistently high blood pressure levels are an issue.

There are two kinds of hypertension:

Primary hypertension is the most common. It develops gradually with no discernible cause, but it may be linked to genetics, physical changes in the body, or high body weight.

Secondary hypertension comes on quickly and can be more serious. It has a number of causes, including kidney disease, congenital heart defects, thyroid issues, alcohol consumption, and certain medications and stimulants, like cocaine and amphetamines.

Since hypertension is often a silent condition, you may not experience symptoms until the condition has developed in severity. At that point, symptoms may include:

headaches

nosebleeds

shortness of breath

dizziness

chest pain

flushing

changes in vision

blood in the urine

If you’re experiencing these kinds of symptoms, it’s important to seek medical attention right away.

CBD is one of the active compounds in the cannabis plant. Unlike tetrahydrocannabinol (THC), it doesn’t have intoxicating properties or produce a “high.” Instead, much focus is on the potential therapeutic benefits of CBD. It may be helpful for everything from pain relief and improved sleep to anxiety, and even addiction.

CBD is available in a few different types: full-spectrum, broad-spectrum, and isolate.

While full-spectrum and broad-spectrum both contain other compounds from the cannabis plant — like flavonoids, terpenes, and other cannabinoids — full-spectrum CBD is the only type that contains some THC (usually less than 0.3 percent).

CBD isolate is pure CBD. But it’s important to know that any type of CBD may contain trace amounts of THC that could show up on a drug test.

These three forms of CBD are made into a variety of products, including:

Oils and tinctures. These liquids have been infused with CBD. You can either place them under your tongue or add them to food and drinks.

Edibles. Sometimes, CBD is added to foods like gummies or drinks like teas. Edibles are among the most popular methods of consumption because they’re discreet and easy to dose.

Capsules. CBD can be taken in pill or capsule form.

Topicals. Topical CBD is applied directly to the skin for targeted relief.

Vape juices. These products are designed to be inhaled using a vape pen. Effects are very fast, but there have been reports of lung injuries associated with vaping. At this time, we don’t know if vaping CBD poses the same risks.

CBD interacts with the body’s endocannabinoid system (ECS), a complex system that helps regulate a number of processes in the body.

While our understanding of the ECS is still unfolding, we know it’s made of three components:

endocannabinoids, which are molecules made in the body

endocannabinoid receptors, which are found throughout the body; the main receptors are called CB1 and CB2 receptors

enzymes, which break down endocannabinoids once they’ve completed their function

At this time, researchers believe the primary role of the ECS is maintaining homeostasis in the body. The ECS is linked to a number of processes in the body, including:

appetite and digestion

metabolism

pain

mood

sleep

motor control

Cannabinoids, including THC and CBD, interact with the ECS by binding to the receptors in the same manner as endocannabinoids.

While THC can bind to both CB1 and CB2 receptors, researchers don’t yet understand how CBD interacts with the ECS. One theory is that CBD prevents endocannabinoids from being broken down, giving them a greater effect on the body. Another theory is that CBD binds to a receptor that researchers haven’t identified yet.

There is research from 2011 that suggests taking both THC and CBD, along with the other compounds in the cannabis plant, may be more effective than using a single cannabinoid alone. This theory is called the entourage effect, and it’s why some people say full-spectrum CBD works better than broad-spectrum or isolate.

There is evidence that CBD products could help lower blood pressure, but research is somewhat contradictory.

A 2017 study of nine male participants found that a single dose of CBD in healthy participants lowered blood pressure for those at rest and those who were under stress.

Another 2017 study in mice found that CBD significantly reduced stress-induced increases in blood pressure and heart rate.

But a 2020 study in rats found that CBD wasn’t effective in lowering blood pressure, though it did have an antioxidant effect. Another 2020 study was more promising, with results demonstrating that CBD could reduce blood pressure in patients who were stressed.

Researchers acknowledge the beneficial effects of CBD for cardiovascular disorders, but note that additional studies are needed to fully understand how it might contribute.

Both the Food and Drug Administration (FDA) and the World Health Organization (WHO) acknowledge the potential benefits of CBD.

A 2017 WHO report describes CBD as generally well-tolerated with a good safety profile and no effects that might indicate the potential for misuse or dependence.

The FDA notes that more research is needed, and it points out that there are many unanswered questions about CBD’s safety. Furthermore, it notes that some CBD products are inaccurately labeled and of questionable quality.

If you do decide to try CBD, know that some people experience side effects, including:

diarrhea

changes in weight or appetite

fatigue

Research from 2012 on cannabinoids and anxiety suggests that some cannabinoids may have a biphasic effect, meaning they produce different effects depending on the dose you take.

For high blood pressure specifically, a 2011 study found that THC alone or in combination with CBD sometimes resulted in an increase in blood pressure, and sometimes in a decrease.

Finally, it’s crucial to keep in mind that CBD may interact with some medications, including those used for hypertension. If you’re considering using CBD to help manage high blood pressure, talk with a doctor first.

While CBD comes in many forms, the best option for high blood pressure is likely an oil or tincture rather than a topical or edible. Oils tend to offer higher bioavailability, which means a greater absorption rate for more efficacy. Sublingual products also have a full-body effect.

The FDA doesn’t regulate CBD products the same way they do supplements and medications, which means consumers must be careful about the brands they use. To find a quality CBD product, it’s important to check for a few things.

Certificate of analysis

Avoid purchasing CBD products that don’t have a certificate of analysis (COA). A current COA means a product has been tested for safety and purity by a third-party lab. Many brands make these reports available via a QR code on the product packaging or on the website.

When you review the COA, check to see if the amount of CBD and THC that the lab found matches what’s being advertised. Also, look at the contaminant testing results to be sure there aren’t unsafe levels of pesticides, heavy metals, or molds.

FDA warning letters and lawsuits

If a CBD company is making unverified health claims, the FDA will send a warning letter. You can check online to see whether a company has been the recipient of such a letter, as well as whether it’s been involved in any lawsuits. If you see that a company has received one, they may be best to avoid.

Customer feedback

Look for customer feedback on both the company and the product you’re considering to get an idea of efficacy. Keep in mind, though, that some brands may:

only publish positive reviews on their sites

remove reviews that mention specific health conditions in order to comply with FDA rules

Transparency

Always peruse the website of any brand you’re interested in. Some brands will be very up front about where they get their CBD from, as well as how they make their products. These are the brands you’ll want to buy from.

Don’t rely on CBD alone to lower blood pressure. It’s important to talk with a doctor and follow what they prescribe. This may include medication.

There are also home remedies that can help manage the condition. A nutritious diet rich in fruits, vegetables, whole grains, and lean proteins is important, along with managing weight and exercising regularly. Maintaining a low sodium diet is also advised.

Stress management is also key. Things like meditation, massage, yoga, and even deep breathing are worth exploring to reduce stress.

Finally, smoking can also have an effect on blood pressure. Chemicals in tobacco smoke are damaging to tissues in the body and harden the walls of blood vessels. Alcohol can also raise blood pressure, so limiting your intake can help.

Before trying CBD to help manage high blood pressure, it’s important to speak with a doctor. Regular checkups are also a good idea, as symptoms of high blood pressure don’t often begin until the condition is more severe.

If you’re noticing symptoms, or you can’t remember the last time your blood pressure was taken, it’s a good idea to talk with a doctor.

High blood pressure can be dangerous, and it’s a condition that may not be noticeable until it’s serious. Fortunately, there are medications and lifestyle changes that can help, and there is some evidence that CBD is another option worth exploring. Before you do, however, consult a doctor.

Jessica Timmons has been working as a freelance writer since 2007, covering everything from pregnancy and parenting to cannabis, chiropractic, stand-up paddling, fitness, martial arts, home decor, and much more. Her work has appeared in mindbodygreen, Pregnancy & Newborn, Modern Parents Messy Kids, and Coffee + Crumbs. See what she’s up to now at jessicatimmons.com.

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thecbdmagazine · 4 years ago

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CBD Addictive

CBD is a reputable material with uses versus swelling, high blood pressure, epilepsy, as well as clinical depression, to use a couple of instances. What's fascinating concerning this molecule is that it can frequently alter different other kinds of medications that could be damaging. For example, CBD can be utilized rather than resting tablet computer systems and likewise has less destructive impacts.

Today, we're also figuring out that CBD can change high-risk, opioid-based drugs. Therefore, it's currently thought-about a severe therapy choice in managing the globally opioid issue. In fact, CBD could additionally have the ability to decrease the habit-forming activities along with withdrawal symptoms and signs caused by countless other medications. So specifically simply exactly how does it operate? In addition to what kinds of addiction can it assist with? Continue analysis to find what CBD can do for people that handle reliance.

What is CBD?

CBD is a bit also called cannabidiol. It's uncovered in the cannabis plant, in addition to numerous other cannabinoids. What's distinct worrying CBD is that it has a lot of wellness in addition to wellness residences, nonetheless, does not trigger a high. As an instance, CBD can:

Reduced discomfort together with inflammation

Quit seizures

Aid digestion

Get rid of stress and anxiety in addition to anxiety

Work as a resting aid

Help youngsters with autism

Treat skin disease like dermatitis, psoriasis, and likewise acne

CBD handles the body by binding with the CB1 in addition to CB2 receptors, which turbocharge the endocannabinoid system. This natural system is answerable for handling a lot of the features of our body, containing discomfort, stress tracking, swelling along with sleep. This makes CBD beneficial for caring for great deals of signs and symptoms and also signs, assisting with hundreds of specialist conditions.

CBD products which include trace quantities of THC (less than 0.3%) are presently lawful on a government level in the USA. Nevertheless, they are not FDA-approved, and furthermore might still be unlawful in certain states. Examine your local regulations before buying.

Is CBD regular developing?

CBD is usually misinterpreted for THC, yet both particles operate in completely numerous approaches when it involves addictiveness. THC is a psychedelic bit; it binds with endocannabinoid receptors as if affects the working of the mind to produce a feeling of ecstasy. Although it's not considered an exceptionally addicting drug, THC-high cannabis can create dependency, specifically in people that utilize it to deal with concerns like relentless pain and clinical depression.

On the other hand, CBD is not an addictive material. It can be safely utilized each day, without the consumer ending up being reliant on it. And as a benefit, CBD does not produce resistance either, indicating you can keep utilizing it continuously without requiring to raise the dose.

Not merely does CBD not create dependency, examinations are now starting to disclose it can deal with dependence on various other products. Right here's what we comprehend so far.

CBD as well as dependence research studies

Addiction defines a state in which an individual is unable to live without a foreign substance. Individuals that care for reliance suffer extreme psychological as well as also physical injury from the item they take, yet appear like they can not live without it. With time, a psychedelic compound can develop adjustments in the fashion in which the mind functions, making it reliant on the medicine. When someone with a reliance gives up making use of material, they'll experience:

Elevated anxiety as well as likewise anxiousness and also stress and anxiety

Solid feelings of despondence

Almost unbearable food yearnings for the material

Oftentimes, they may furthermore experience physical withdrawal indicators. For example, withdrawal from benzodiazepines can cause drinking, excessive sweating, palpitations, in addition to in addition also muscular tissue pain.

What develops dependence? So far, scientists assume reliance is created partially by the substance itself when it's taken frequently, as well as partially by hereditary tendencies. Frequently, individuals will definitely start making use of medicine for satisfaction or because it handles countless of their signs. Yet with time, they begin taking it an enhancing variety of typical and also furthermore increase the dosages. Eventually, they're no longer able to run without it.

Taking care of reliance is hard, as well as it frequently needs a mix of medicine, psychiatric therapy, in addition to similarly team treatment or help networks. Today, some researchers are uncovering that CBD might similarly be made use of as an equivalent treatment option, helping people to quit making use of it in addition to minimizing their withdrawal signs and symptoms and also signs. Right here are the most existing research studies on the subject.

CBD in addition to opioids

An opioid is an item with effective sedative impacts. It's very successful in taking care of furthermore one of one of the most severe sorts of pain, along with can in addition create feelings of bliss. Some sort of opioid medications are authorized, like codeine, morphine, along with also oxycodone. A couple of other types of opioids like heroin, opium, along with furthermore fentanyl, are prohibited.

Accredited or otherwise, opioids can trigger dependence as well as furthermore uneasy withdrawal signs for those that try to leave them. This is fretting due to the reality that they're normally suggested as drugs for those dealing with persistent discomfort.

CBD can assist people with consistent pain to continue to be clear of winding up being addicted to opioids by functioning as a various pain reliever. Some looks into have actually revealed that CBD can be a very efficient medicine, likewise for clients with the discomfort that is tough to treat. In a great deal of situations, CBD could still not be effective sufficient to change opioids. Nonetheless, it can still be made use of together with opioid-based medicine, lowering the option of opioids that discomfort sufferers take.

And also, even for individuals that struggle with reliance on drugs like heroin or morphine, CBD can be a type of treatment. Scientists started studying the results of CBD on those with opioid addiction over a year ago. In 2009, they observed the end results of daily CBD on rats with heroin dependency.

They discovered that taking CBD reduced heroin-seeking activities-- basically, making the rats a lot less addicted. The results of CBD lasted well after the last dosage, reducing heroin cravings also 2 weeks down the line. In a 2013 study, scientists had a look at the influences of CBD on the reward system of our minds. They located that taking CBD lowered the "boosting residential properties" of opioids.

The strengthening structures are the impacts the medications have on the brain, essentially giving substantial benefit signals that make you really feel thrilled. What this recommends is that taking CBD could make opioids much less "pleasing." Simply put, people that take them for discomfort surveillance would certainly still obtain the discomfort alleviation they need out of them, yet they would certainly not genuinely feel as much of the psychological motivation that makes them addictive.

CBD along with pure nicotine

Cigarettes can be very addictive due to the fact that they consist of pure nicotine, a psychoactive particle with a trustworthy impact on the brain. Today, we're starting to comprehend that the endocannabinoid system plays a crucial function in nicotine addiction.

In a 2013 research study, scientists gave a CBD inhaler or a sugar pill to cigarette smokers that were attempting to give up. After a week, those who were given CBD smoked 40% less cigarettes than those in the sugar pill control team. The scientists concluded that CBD would definitely make a fantastic capacity therapy for those with pure nicotine reliance.

CBD along with energizers

Stimulant medications like medication, amphetamines in addition to meth are numerous of among one of the most habit-forming products around. With routine usage, people can establish a strong reliance that needs significant treatment. These regimens in a big part of the truth that stimulants interfere with the mind's reward system. Taking a stimulant releases big amounts of dopamine at one time, which uses a satisfying experience of joy. Yet as without delay as an exclusive stopped taking the product, they will most definitely feel a trusted low because their brain says goodbye to creates dopamine appropriately.

In 2013, a group of researchers concentrated on the state of cannabinoid receptors in rats with medication dependence. They uncovered that the endocannabinoid system played an essential function psychological chemistry of people addicted to drugs. Rats that depended upon medicines had reduced selections of CB1 receptors, which recommends that their endocannabinoid system was not working as it should. By boosting the task of the endocannabinoid system, CBD could counterbalance that effect, revive the balance in the bodies of people addicted to medications.

A 2016 study subjected that CBD might control the dopamine path in the mind, combating the effects of amphetamines. This utilizes us really hope that might be used to help people addicted to amphetamines and likewise bring their mind chemistry back to typical in order to take care of withdrawal signs and symptoms.

Different various other valuable effects of CBD

These researches disclose that CBD can be crucial in decreasing yearnings as well as likewise revive healthy and balanced along with well balanced mind chemistry in individuals with medication addictions. Yet that's not where its advantages quit. CBD has various other outcomes on the mental disorders that might make it dependable in taking care of withdrawal indicators.

As an instance, CBD screens solid anti-anxiety homes. Stress and anxiety, in addition to anxiousness and also stress and anxiety and anxiety, are truly normal when people quit taking a product they have actually ended up being reliant on. Taking CBD may help them really feel calmer as they undergo this hard stage of the recovery procedure.

Gotten in touch with that stress and anxiety, individuals that experience medicine withdrawal signs generally have difficulty resting. Again, CBD could be essential as a result of the truth that it helps people rest much better, along with lowering nervousness.

Lastly, CBD has antidepressant residences, which can help people handling reliance escape a very decreased state of mind as they give up using a substance.

#CBD addictive

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babblingbr00k · 6 years ago

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Seek Me & You Shall Find Me

Rule 1: Prescribed medications such as: antidepressants, pain medicine, anti-anxiety medicine, sleep medicine were completely banned at ATWH. The only medication that we were allowed to bring in and take were over the counter medication and Prescriptions that were deemed necessary to prevent harm/or death. The theory behind this is our very first commandment. Thou shall have no other Gods before me.

I remember, as the wind blew the moon and the darkness in, being very anxious and over emotional. I cried uncontrollably. I was petrified of night, scared of being awake and alone. I was completely at the mercy of the monsters my 2nd night wanted to inflict. The only thing keeping me from bolting out the door, was the knowledge that I had nowhere to go.

It had now been over a week since I had my last dose of my Effexor, the antidepressant I had been on for 8 years since my brother died. It had also been 2 days since I had had my beta blocker. The medication that kept my heart from beating too fast.

My body was now detoxing from amphetamines, opiates, antidepressants, and a beta blocker. If I were to label my discomfort on a scale of 1-10, 10 being the worst. I was suffering at an unimaginable 67.3234.

I cannot express to you how much I wanted to die.

I stopped praying for the strength to get through this. I was now praying, begging, albeit DEMANDING for God to give me the strength to kill myself.

Like a child, I was clingy to Emma. Where ever she went I was sure to follow. If she were to sit down or stand still for longer than 2.5 seconds, I would force my way into her arms. Her petting, rocking, and cooing…...helped. But I could tell that, after several hours, she was beginning to get annoyed with the lack of personal space I was willing to give her. It wasn't long till I noticed Emma start to withdraw from me. When I would enter into a room, she would leave. She spent the rest of the evening with Kennedy.

Que private pity party of a catastrophic level. Abandoned again!!!

I was still unable to eat without it coming right back up. I was now crossing into the 48 hour mark of being unable to consume and keep anything of nutritional value in my stomach. I remember not being bothered by this. When I stood on the scale in the bathroom that morning, I was shocked when my weight read almost 270 pounds.

Our bodies start to burn excess fat after 2 days without eating. It’s also around this time that our adrenal glands start to pump endorphins into our system. It’s our bodies way of protecting itself from the pain of hunger pains. I remember looking forward to all small bit of relief that was headed my way within the next 24-48 hours.

Nine o'clock came and it was time for our circle of prayer. We all gathered in the middle of the room, formed a circle and held hands. I angrily “passed,” while the rest of the girls prayed. Immediately following prayers I went and climbed into my bed. Emma, who spent the entire day soothing me, wouldn't even look at me. I layed there wide awake, listening to the other girls drift off to sleep, wondering what kind of hell the dark corners of my mind had to offer the insommed.

I’m not sure how long I laid in my bed, twisting and turning, trying to get comfortable.

The only way I can explain how this feels is: imagine laying down, initially being able to lay still and comfortable for 20 seconds or so. But you start to feel a painful tingling sensation in your feet. It’s similar to the painful tingling your arm or your leg experiences when it’s “waking up” after having been deprived of blood flow for a little bit of time. This “tingle” slowly makes its way up your legs, into your back, then your shoulders, and finally into your arms. Movement of your extremities usually eases this feeling. But once you have done your little bedside boogie and start to get comfortable again, the tingling rallies, crawling up your legs once again for another attack against every inch of your body. It’s called Restless leg. Imagine going through this every couple of minutes for 9 hours straight.

I layed there in that little twin bed for hours, listening to the soft breathing of the other girls as they peacefully slept. I twisted and turned, changing positions every couple of minutes in an attempt to ease the Restless Legs. The sheets were that low thread count, so there were little bubbles that irritated my skin.

I found myself an interesting little rhythm.

Stomach….

Right Side….

Back…..

Left Side….

Now reverse….

Left side….

Back…..

Right side…..

Stomach….

Now do the Stanky Leg and the Dab….

I fought, for what seemed like hours. I didn’t care if anyone saw me. Desperate to try ANYTHING, I even attempted the Hands and Knees Down/Butt Up pose that we all resorted to as a child. It didn’t take long for me to abandon said pose. See, with my bowels being in the shape that they were in due to my detoxing, the only thing that this pose accomplished, was a bit of Brook’s Backdoor Homemade Airfreashner.

Abort!!!!!

Back to the ole Four Turn Tango.

Stomach….

Left Side…

Back….

Right Side….

Now reverse..

Right Side….

Back…..

Left Side….

Stomach...

….Now do the Stanky Leg and the Dab….

I HAVE TO GET OUT OF MY BODY!!!

I jumped out of bed and started running in place, jumping up and down. I was at war with my body. Using my hands, I assaulted every inch of my body. Beating my legs, my stomach, my butt, and finally my head. I thought, maybe, I could beat this feeling out of me.

Winded, I stopped to catch my breath. I realized that I had forgotten where I was. I looked around the room and remembered where I was, and that I wasn’t alone. I closely observed each girl as they laid in their own bed, checking to make sure none of them were awake to witness my self inflicted assault to my detoxing body.

I looked down at my bed and felt a wave of hate wash over me. Hate for my bed, hate for my sick body, hate for Phillip for abandoning me, hate for my parents for throwing me away, and hate for God who had forsaken me.

I never wanted to see that bed again. I grabbed my pillow and blanket made my way into the dark living room on the other side of the house.

I threw my pillow and blanket on the full sized couch and introduced myself.

“Couch...I’m Brook….I wanted to introduce myself. I felt it was the polite thing to do. Ya see….I’m about to lay down and try to get comfortable enough to get some sleep. But...the way this night is playing out….I have a feeling things are gonna be getting real freaky.”

I gave my new friend a gentle pat, laid down, and prayed that I would quickly fall into a peaceful sleep.

I started to count….1…..2…..3…..4…………………

It was around the 27 second mark that I felt the tingling in my feet.

..aaaaannnddddd here we go…..

Stomach…..

Left Side….

Back….

Right Side….

Now reverse…..

I now added the beat from Cat Nie Jo to my new nightly routine.

Right Side…..

Back…..

Insert the Nae Nae

Left Side……

I stopped mid Stanky Leg and burst out into an uncontrollable fit of laughter. I laughed so hard that I started to cry. I even wet my only pair of semi clean underwear.

I know what your thinking, but I’m not going crazy. Well, not completely anyway. See if you have the ability to laugh at yourself or have a little bit of fun in a situation that is fucked up….well...you just learned a valuable coping skill my friend. Good Job!!

I calmed down and finally caught my breath.

I was now pissed off at the couch. She could, literally, kiss my ass. I grabbed my pillow and blanket and shuffled over to the Love Seat.

Politely introduce myself to my new freaky furniture friend.

“Let’s get busy…..”

I remember wondering how long those couches had been there and how many asses they had seen through the years.

Moot…..

Well hello racing thoughts, wouldn’t be a party without you. I was wondering when your ass was gonna show up. Come on in and join this Fuck Fest Of Chaostrophic Proportions!

My thoughts bounced around from one random thought to another.

I went from thinking about the couches to thinking about my 1970’s couch that I got free when I moved into my first apartment when I was 21.

Fox Run Apartments.

What was the name of that Disney Cartoon?

Oh yea...Fox and the Hound.

You ain’t nothing but a hound dog….crying all the time…

What time is it? Where’s the damn clock?

It’s almost midnight.

It’s Tuesday. Almost Hump Day.

Why Hump Day? Who had the bright idea to name Wednesday Hump Day.

Maybe he had a standing reservation with his wife every Wednesday. His designated booty day.

Booty...God my booty hurt. 3 days of diarrhea will put serious wear and tear on the badonk-a-donk spout.

Whale spout. They have to come up for air every 15 minutes.

An alligator can hold its breath 30-60 minutes.

Humans risk brain damage after 3.

Brian Love...the little 5 year old boy that was hit by a car. My first Meritorious Service Award. I got to ride in Air Med because the Paramedic needed an extra set of hands. While he worked on little Brian, I had to squeeze the bag once every two seconds. Delivering oxygen into his little lungs.

Before I could make the transition into my next random, racing thought, I was interrupted by a very familiar high pitched squeaking. I didn’t get up immediately.

I wanted to give God a minute. I prayed that He would take him quickly.

"Please, God, spare me from THIS tonight."

I wasn't too keen on becoming a mouse serial killer. But after a minute or so of waiting for God to do his own damn job, I reluctantly got up. I cursed God, yet again, and followed the trail of audible suffering...my broom at the ready.

This time my dude was in the kitchen. I walked in and turned on the bright fluorescent lights. Curse!! Curse!! Curse!! Damn everything and everyone to hell.

Rule 2:Swearing and taking the Lord's name in vain will NOT be tolerated at All The Way House. If you refuse to abide by this rule, you will be expelled from the program and not allowed to return.

I found my next victim glued to a glue trap under the shelving of cooking supplies. Just one guy, he had only just started chewing off one of his paws.

Broom handle down, heart hardened, tears falling, taking aim, prayer for forgiveness, stab, stab, stab, die, die, die!!!

I stood there with him, watching, keeping him company, until the jerking stopped and he was gone.

“Fuck Forgiveness.” I tried to convince myself that putting the mouse out of his misery didn’t bother me.

But the tears falling down my face told me that that statement was a huge lie.

I disposed of the corpse, then stood in the kitchen and continued to cry. My happiness from new clothes long forgotten. I took stock of the collection of knives and debated on whether I should leave my own corpse for the girls to find.

It wasn’t until after I noticed the 8 foot, side by side freezer that I told myself, "I'll think about that tomorrow," (que Scarlett O'Hara.)

I dropped my killing instrument and made my way to the freezer. I stood there, before this gigantic, silvery door to Narnia, and said a quick prayer.

"Please, for the love of all things good, let there be contents within worthy of my sophisticated pallet."

The doors were heavy and I had to pull past the suction. There was no way in hell I would be denied my, "due and proper."

Once I had the doors opened, I could see stacks of fruit, plate lunches for the next day, and.....gallons of ice cream. Well you could have called me Chunk and told me to do the "Truffle shuffle," for all I cared. As far as I was concerned, God put this mountain in front of me, and by God, I would conquer it.

"Screw this," I said out loud. "If I can't stab myself to death, I'll fucking eat myself to death." I grabbed the gallon of strawberry cheesecake bliss, grabbed a ladle and happily resigned myself to eating my way to 300 lbs, diabetes, heart failure, then finally sweet death.

"How does this fit into your 1st Commandment?" I said under my breath.

I closed my eyes and pretended that I was shoveling Opana laced ice cream into my mouth and down my gullet. It was the severe brain freeze and subsequent nausea that made me stop. I threw my gifts from God to the side and ran to the bathroom, shoved my finger down my throat, and gave the porcelain God the contents of my stomach.

Once everything was up and out, I sat back onto the bathroom floor and caught my breath.

Brook? You are working yourself up. You have got to get a grip. The only thing this is doing is making it worse.

I took a deep breath and opened my eyes. On the toilet and walls was an abstract art piece that would have made Picasso proud. The white, pink, and red spew was a beautiful contrast to the faded green wallpaper. In the corner, an unknown, and suspicious brownish smudge made up a smile that went along with my strawberry eyes and nose.

I looked myself. What a waste. I had regurgitation in my hair, on my face, and down the front of my night shirt. I looked down to the floor and saw that I was sitting In a puddle that I had not noticed before. It was the smell drifting up that informed me that I had soiled myself (#1 & #2) during my peritoneal purge.

You can safely assume that I was at my most lowest point. I didn't just hit bottom. If you had had the desire to seek me out and try to find me, I was there, several 100 feet below rock bottom.

I submit

Uncle!!

I give up!

relinquishing,

86'in this shit,

have no fight left,

abdicate,

retreat,

withdraw,

yield,

abandon!!

I’m going to Davy Jones Mother Fucking Locker!!

I WANTED TO DIE!!! Why have you forsaken me God? Why have you abandoned me in my most desperate time of need?

I laid there, on the dirty, sticky bathroom floor, covered in my own piss, shit, and vomit. As much as I wanted to give up, I decided to give God one last call. This was my Hail Mary.

I distinctly remember whispering,"Help."

Then I waited.

And I listened.

………….

It would have been so easy to lay there, continuing to feel sorry for myself. It would have been easy to admit defeat and finish digging my own grave on the tiled floor. All I had to do was pull that dirt in on top of me.

Bury me here. Peace Out Bitches!!

I, soon, felt my body start to relax as I drifted off to sleep. I started to dream. In my dream I heard a voice and felt a presence that I hadn't felt in over 8 years. It was the comforting, yet insistent, voice of my brother , Coleson.

"Come on El Negro! (that’s what he called me) Not here and not like this. Get up!"

It would be amazing if I sat here and told you that it was the voice of my brother that got me off that floor and into the shower. It wasn't. I sprang up and out of my fetal position with an overwhelming need to throw up again. I dry heaved into the toilet as I #1 and #2'd all over myself for the 2nd time. When the gagging was done, I stood up and glanced over at my strawberry smiley face abstract piece.....and told him to go fuck himself.

For some reason I started speaking in first person.

"Brook is better than this."

“Brook doesn't just give up."

"Brook is a warrior and will fight."

“Brook smells like shit and needs to get her ass in the shower."

After my shower, Laying in my bed, before I drifted off into a semi-peaceful sleep, I promised myself, and whoever else was listening, that I was going to see this through. No more talk of killing myself or feeling sorry for myself. I had two feet, and dammit, I was going to stand on them.

Was that actually Coleson? Taking a minute to boss me around from the afterlife? Or was I finally entering the hallucination phase of death?

Well whatever you wanna call it, it worked. I got up, took a shower, put on clean clothes and went back to bed. It's possible that my self conscious created my brothers voice in a moment of self preservation. My brain told me what I wanted to hear, in a voice I was yearning to hear.

I knew that me giving up wasn't an option. If I wanted to live....I would have to fight.

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jswdmb1 · 6 years ago

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Champagne Supernova

“How many special people change?

How many lives are living strange?

Where were you while we were getting high?”

- Oasis

Let me start by saying I don’t celebrate 4/20 as a holiday, but I get the joke, so I’m in on it today too. Let me follow that with this is not a post about me being jealous. If I wanted to smoke some dope, trust me it would be happening, and I couldn’t give a shit who thinks I should or shouldn’t. And, that’s what really bothers me about this whole push to legalize weed, particularly in Illinois where it is just a cash grab. It distracts from the fact that our entire oversight of “drugs” in this country is so massively whacked and is completely unfair. To isolate marijuana as the one drug that needs reform is the most stupid as it is probably the least of our worries.

Before we go further, we need education on the root of the problem which is the bullshit classification system used by the federal government. Here are their definitions of the five different classes (as per Dr. Tim Sams in his book “ABC’S OF PAIN RELIEF AND TREATMENT”:

SCHEDULE 1 (CLASS I) DRUGS are illegal because they have high abuse potential, no medical use, and severe safety concerns; for example, narcotics such as Heroin, LSD, and cocaine. Marijuana is also included as a Class 1 drug despite it being legal in some states and it being used as a medicinal drug in some states. SCHEDULE 2 DRUGS (CLASS 2) DRUGS have a high potential for abuse and dependence, an accepted medical use, and the potential for severe addiction. These drugs include opiods based on high dose codeine, Fentanyl, and Oxycodone as well as Methamphetamine and the Barbiturates; also included are such drugs as opium, morphine. Adderall is even included in this category under "mixed amphetamine salts". The main difference between a Schedule, or Class, 1 and 2 is whether or not the drug is deemed to have a valid medical application. SCHEDULE 3 (CLASS 3) DRUGS have a lower potential for abuse than drugs in the first two categories, accepted medical use, and mild to moderate possible addiction. These drugs include steroids, Low-dose Codeine, and Hydrocodone-based opiods. SCHEDULE 4 (CLASS 4) DRUGS have an even lower abuse potential than Schedule 3 Drugs, accepted medical use, and limited addiction potential. These include most of the anti-anxiety medications like the numerous Benzodiazepines, Sedatives, sleeping agents, and the mildest of the opiod type medications like Darvon and Talwin. SCHEDULE 5 (CLASS 5) DRUGS have a low abuse potential, accepted medical use, and a very limited addiction potential. These consist primarily of preparations containing limited quantities of narcotics or stimulant drugs for cough, diarrhea, or pain.

The first question that comes to mind is where are nicotine, caffeine and alcohol on this list? The answer is nowhere. All are considered normally occurring substances that all people consume in small quantities through natural means (for examples, tomatoes have some nicotine in them) therefore they cannot be regulated. That is the biggest load of government crap to ever come out of the back of the truck. Based on that logic, all opioids should not be anywhere on the list because I can get some of that by eating a poppy seed muffin. And, marijuana is as natural of a substance as anything, so why is growing and consuming it illegal but not poison mushrooms. I’m not arguing here about what should be classified as Schedule 1, 2, 3, etc., I’m arguing that the schedule itself is insane and actually immoral.

What do I mean by that last part? If you are poor, you are more likely to gravitate to the drugs that are on Schedule 1. I know that is a generalization, and that all sorts of people use Schedule 1 drugs, but go look up the stats behind who is in jail for drug offenses (seriously, go look it up, I’m done doing your homework for you), and it is overwhelmingly poor and minorities. It’s awfully convenient to keep marijuana on Schedule 1 to keep that prison economy going and it is equally convenient to let tobacco roam free killing millions a year to keep that industry awash in cash. Meanwhile a whole segment of our population is brutally oppressed under laws skewed to serve those in power and money. It is about as un-American as things get, and that is during a time when just about everything that comes out of that sewer hole that we call Washington is un-American.

I’m going to keep this short, because there is not much to say. Get rid of the fucking schedule of drugs and take a completely different look at how we manage this problem in the U.S. Stop putting people in jail and get them real help for their problems whether it be pain, addiction, or poverty. Immediately commute the sentences of anyone in jail for non-violent drug-related offenses and expunge their records. Then reset how you are going to regulate everything that needs to be regulated. From my perspective, prohibition of anything seems counterproductive as long as it is not hurting other people, but that also doesn’t mean certain things shouldn’t be controlled. What should be controlled and not controlled should be decided by people who actually know what they are talking about. Real doctors who are specialized in such matters should be helping to craft policy. I know that excludes me, and it certainly includes any politician most of whom I wouldn’t trust to make a cup of coffee never mind handle something as important and technical as this.

So, get a blue ribbon panel together and let’s end the “War on Drugs” and direct our efforts to reengineering this entire process. And, let’s look at how we can really help the segment of our society that needs it the most instead of shunning them and locking them up. How will this be funded? Not a new tax on individuals, but just start siphoning profits from the companies selling cigarettes and prescriptions that are really killing people. Until that happens, leave me out of the 4/20 celebrations. Not because I’m bitter that I’m sober now, but because there is nothing to celebrate. Not while millions suffer with addiction, some in prison, while the power brokers get rich off their misery. So feel free to light up today, just ponder while you eat your post-smoke box of Twinkies why you really can’t enjoy weed freely and even more puzzlingly why Twinkies are not Schedule 1? I mean is there anything else that exists that lacks value or is as highly addictive as those little bastards? That should blow your mind whether you are high or not right now.

Cheers,

Jim

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riceangle4-blog · 6 years ago

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'People were just bleeding': Doctors describe tainted pot emergency

© Provided by NBCU News Group, a division of NBCUniversal Media LLC Image: Synthetic Marijuana, Or K2, Use On The Rise In New York CityA man prepares to smoke K2 or "Spice", a synthetic marijuana drug, along a street in East Harlem in New York City on August 5, 2015.

Some of the patients were coming in with bleeding from almost every orifice: their ears, their eyes, in their urine. Their symptoms were mysterious and severe and emergency room doctors across much of Illinois were mystified.

Some worried about Ebola, the viral hemorrhagic fever feared for the uncontrolled bleeding it was reputed to cause. Others struggled to dose patients with fresh plasma, which delivers natural blood clotting factors.

After frantic calls to one another across the state, doctors figured out that the patients had all been using synthetic marijuana — a product known variously as K2, Spice, Kush, Kronic, or Scooby Snax. It provided a cheap high and was sold in gas stations and convenience stores.

But why such dramatic injuries?

"People were just bleeding from some unknown cause," said Dr. Jonathan Roberts, a blood specialist at the University of Illinois College of Medicine at Peoria.

More calls and more tests established that some of the products were contaminated with what are known as super-warfarins - blood thinners that are most often given to people with heart problems that make them susceptible to blood clots that cause heart attacks and strokes.

It was not immediately apparent, however, what to do to help the patients. It turns out it's both easier and harder than anyone thought, Roberts and colleagues reported in Thursday's issue of the New England Journal of Medicine.

Roberts and colleagues described a string of cases seen at Saint Francis Medical Center in Peoria between March 28 and April 21 of this year.

There's a standard test to measure how blood is clotting. These patients were off the charts in terms of clotting dysfunction, Roberts said.

The best treatment, they found, was vitamin K. It's a low-tech way to get blood to start clotting again, and usually a few pills will set a patient right again.

It took more than a few pills to take care of this particular group of patients, however. Over a period of a few weeks this past spring, more than 150 people were brought in suffering from bleeding disorders. They were all later linked to tainted synthetic cannabinoids.

The drugs, for reasons that remain unknown, had been contaminated with super-warfarins, Roberts said. "These are rat poisons," he told NBC News. They earned their name because their effects are prolonged. "In humans, the effects can last for months," he said.

The people who ingested the tainted K2 would need to take vitamin K in large doses for months in end.

That may seem like a simple solution, but it wasn't.

"It is actually very expensive," Roberts said. "It's somewhere around $24,000 to $34,000 a month." Pharmacies didn't carry the kind of stock needed. "In central Illinois, we ran out of oral vitamin K," Roberts said.

The doctors sought donations from non-profit groups. Dr. Amar Kelkar, a resident at the hospital at the time, called Valeant Pharmaceuticals to try to get the company to donate some supply. Valeant eventually did give 800,000 doses to the Illinois Department of health last April.

But the kind of patients who seek out a cheap high at gas stations are not always the type who will follow medical directions carefully, who have good health insurance, or who are likely to check back in for follow-up treatment. Many remain at risk for hemorrhages.

"We had trouble getting patients to pay for it," Kalkar said.

And there are still fresh cases. Illinois has had more than 160, and cases of people poisoned by synthetic pot cut with rat poison have been reported in Connecticut, Washington D.C., Wisconsin, and Maryland.

"I have had patients since this study was done that have come in bleeding from multiple places �� the eyes, ears, vomiting blood, coughing up blood," Roberts said.

"We have had some patients who are literally bleeding from every orifice."

Kalkar, Roberts and colleagues wrote their article so that every emergency room or clinic that may see patients affected by these rat-poison-tainted drugs knows what to do.

The vitamin K, they say, is highly effective is used in high enough doses and for long enough. It's a standard treatment for when a heart patient gets their warfarin dose wrong and has blood coagulation problems.

But the super-warfarins call for much more than normal.

"They need significantly higher doses than the average patient taking warfarin would need," Kalkar said. "It was even challenging to get buy-in from some doctors. They wondered why patients might need such exceedingly high doses."

Synthetic pot is made by taking plant material and spraying it with chemicals that can mimic the high from marijuana. It is a Schedule 1 drug, joining cocaine and heroin as a drug with high abuse potential and no medical benefit.

It's not known why anyone would contaminate these products with blood thinners.

One theory is that they are supposed to prolong the high by interfering with the metabolism of the cannabis-like drug. "There is also a potential for malicious contamination, either by a drug manufacturing competitor or as an act of bioterrorism," Kalkar and colleagues wrote.

The team described the case of one victim who died. The 37-year-old woman mystified the trauma team when she came in unconscious.

"Recent use of synthetic cannabinoids and amphetamine was reported at admission by her friends who brought her to the hospital; they did not report known head trauma," the team wrote.

A CT scan showed she'd had a brain hemorrhage. Doctors gave her giant doses of vitamin K and four units of plasma, but it was too late to save her.

"Fifteen hours after presentation, she met criteria for brain death," the team wrote.

The only positive note was that her organs could be donated.

Source: https://www.msn.com/en-us/health/medical/tainted-synthetic-pot-users-bled-from-eyes-ears/ar-BBNCilX?srcref=rss

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qualityherb · 6 years ago

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What is SCHISANDRA? The Omega 3 of Puroomega

It is an original plant from the north of China, widely used in traditional Chinese medicine, in Korean medicine and in Russia. It is also called the fruit of the five flavors, since it combines them, and is the origin of its name in Chinese: wu-wei-zi. Schisandra berries have been used in traditional Chinese medicine for more than 2000 years, with properties against stress and fatigue. According to traditional Chinese medicine, Schisandra Chinensis Extract is one of the few herbs that contains the three treasures known as Jing, Qi and Shen (essence, energy and spirit). In the form of tea, in drops or in capsules. The main characteristic of this fruit is that it is highly ADAPTOGENE, this means that it helps to rebalance and restore body energy and improve its balance, as well as improve sleep. So it is very useful as anti-stress but not only that, also as toning depending on the needs. 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A high concentration of cortisol can stop the growth of the muscles. · They increase the concentration of dopamine and serotonin in the brain, which increases the feeling of pleasure and well-being. · Improves the performance of long-distance runners and athletes who are fans of bodybuilding · As if this were not enough, there is more evidence of its effectiveness; for example, it has been shown to improve respiratory and cardiovascular function, improving muscle strength in athletes. · It has also been shown to improve the performance of repetitions in endurance tests, reducing fatigue, muscle aches and shortness of breath. WHY DO WE COMBINE SCHISANDRA WITH OMEGA-3? Due to this unique combination, we are able to offer very powerful products, in which we take advantage of the benefits of both natural active ingredients. On the one hand, omega-3 oil increases the bioavailability of schisandrins. This means that more schisandrins enter our body and therefore we can take advantage of its beneficial effects with a lower daily dose. On the other hand, both schisandrins and omega-3 fatty acids (EPA and DHA) have very similar effects that result in very important synergies.

#Siberian Ginseng Extract siberian ginseng extract powderEleutheroside B+E Eleutheroside B Eleutheroside E

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modalertdotco-blog · 7 years ago

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Modalert From Modafinil

Buy Modalert Online

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It had been put into the Planet Anti-Doping Agency’s listing of banned materials in 2004. Results on Cognitive Skills: Years of study assistance the concept that Modafinil leads to considerable development in a wide selection of intellectual abilities, which range from operating memory and liquid intelligence to both spatial and episodic recollection, design identification, government function, and efficiency on duties that need greater-level thinking. Some reports claim that Modafinil’s results might be most noted among low-. Medical tests established although feeling improves but might lead to panic. DOSE Within the remedy of additional or narcolepsy sleep problems, Modafinil is recommended in daily doses of 100 mg, at least early enough within the day or to become taken upon waking to allow normal rest during the night. For Shift-Work Disorder, the proposed dose is usually 200 mg, obtained one-hour prior to the shift's beginning. The typical dose recommended for adult's therapy ADHD amounts from 100-200 mg and dose for that therapy including mood disorder, of additional problems, exhaustion and intellectual disability due to multiple sclerosis, and habit differs based on each individual. A beginning dose of a maximum of 50 mg is usually recommended, growing the total amount gradually and just as needed to attain outcomes while obtained like a nootropic. The most secure daily serving is usually thought to be 400 mg, and even medical tests claim that A - 400 mg dose doesn’t supply substantially enhanced outcomes over a-200 mg serving, though the chance of negative effects might boost. Modafinil seems to be secure for extended intervals at (100-200 mg) daily doses, and large-scale clinical tests demonstrated no substantial signs of tolerance's improvement over intervals running as much as many months. Even if obtained at reasonable beneficial amounts, mental reliance is just a scarce but unique chance and it has been documented in remote case reports, which documented withdrawal symptoms including insomnia panic, problem, and also the failure to experience enjoyment. STACKING Modafinil + Phenylpiracetam Bunch This bunch continues to be documented to improve emphasis and power, not surprisingly from Modafinil, as the inclusion of ALCAR and phenylpiracetam aid in increasing fluidity of attention thought, and home -observed imagination. Credit for this bunch concept to TramMcD.

#modalert #buy modalert online

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nabrosov · 5 years ago

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Projects of light drugs and anti-cancer drugs.

Hello Department of Medicines, Estonia is a leader in the use of phentalin, and this leads to frequent complications and side effects, high mortality and disability. I think that there is a chance to correct the current situation. I have been working on light drugs since 2004, I am a scientific volunteer and amateur drug designer.

Let me list super soft drugs that people use every day, and it does no harm to them and does not cause addiction. So will be easier to move on to the topic of writing.

Menthol is a super-super light central anesthetic - a dissociative.

Picrocrocin (Crocus sativus, Saffron), relatively light dopaminergic, lighter than cocaine, arecolin (betel nut), amphetamine ... It does not cause dependence, is legal in all countries of the world, an antidepressant, a motivator, almost unreported fatal cases.

Beta Kariofillen (black pepper, cloves, basil), super-super light cannabinoid.

Terpineol (cardamom, ledum, lovage, basil) is a super-super easy opiate. Ledum preparations are non-narcotic substitutes for codeine.

As you can see, even some super-super-light preparations of plant nature are able to qualitatively replace codeine and provide some kind of easy alternative to cocaine, nicotine.

Nature does not always give us balanced and pharmacologically acceptable tools. Drug design can fix many points and adjust quality and quantity characteristics. Nature has shown that light preparations can be a quality tool. For opiates, this approach is necessary because most opiates are consumed on the street and light drugs have a low ceiling for maximum activity. This means that the number of overdoses is theoretically possible to reduce to zero.

Buprenorphine is the best replacement drug to date. This is due to several features of its structure: 1 amine group of buprenorphine is inactivated by the antagonistic radical and hydroxyl is added to the position corresponding to the alternative position of the amino group. This pharmacologically almost turned the alkaloid (amine) into a terpenoid - terpene alcohol, which is significantly less active. 2 taken as the basis of the core - morphine, is a quality core, because they correspond to the main configurations of enkephalins, and at the same time have many fixed cycles, this can reduce extrapyramidal side effects. The drug does not cause a negative reaction of dopamine neurons. Fentanyl causes side effects associated with extrapyramidal activity, this is a feature of its structure and this is can be circumvented.

As you can see, buprenorphine is pharmacologically almost terpene, a complex terpene alcohol. And it works pretty well as with Terpeniol Ledum. I worked on the design of such alcohols and lactones, and I think that we may be able to create an even more unsafe drug. Buprenorphine has a number of disadvantages, it is an amine group, it allows you to increase the activity of the drug while being administered together with complementary acids, such as Ibuprofen, this salt has a short pulse of high narcotic activity. Also, the morphine core has a large mass, and is relatively strongly complementary to the opioid receptor, this leads to a relatively high activity ceiling at elevated doses. And as a result, this drug is dangerous in street conditions. Less dangerous than fentanyl, but more dangerous than it would be if it had a lower activity ceiling and did not dissolve in water (most high molecular weight alcohols are insoluble in water and unsuitable for injection).

A design based on pro-terpene complex alcohols can give humanity water-insoluble preparations with a very low ceiling of maximum activity (almost independent of the dose, with an increase in the dose, the quality of exposure will only drop) and even if desired, those that will not be active when smoking ( Quaternary alcohols are often thermally unstable and when heated, the hydroxyl group drops out of the molecule, the substance becomes inactive). These are incredibly large and well-reasoned prospects(perhaps this is my subjective vision, but I haven’t found any arguments against it).

Perhaps this could be the safest opiate, since most opiates are used on the street, special requirements must be applied to opiates, at a new, more progressive level of understanding of the issue and drug design. Link: https://www.academia.edu/26483613/Possible_new_vector_drug_design._Physiologically_active_alcohols_analgesics_and_dopaminergic.odt

Is it possible to achieve a powerful analgesic effect from such drugs? Not! The withdrawal syndrome, even on a more physiological level, is not what we need, but we can find a way out and find an alternative analgesic. Although in a hospital it may be fentanyl, but as an option I also have a project of non-narcotic opiates and cannabinoids that do not pass the blood-brain barrier. Such substances do not affect the brain, but peripherally block a portion of the signal. Topical use of cannabinoids and endorphins shows good results. This gives us a chance to create a completely non-narcotic drug for severe pain. These substances are quaternary ammonium salts and similar substances have long been used in medicine but not as opiates but as antagonists, since they have a quaternary ammonium salt in the active zone of the molecule, my design suggests the location of such a radical in the inactive zone of the molecule. It should be a drug like Loperamide (an opiate that is not absorbed from the gastrointestinal tract and stops peristalsis) but is injectable and works throughout the body except the brain or for local injection. Link: https://www.academia.edu/38093276/Non_narcotic_opioids_and_cannabinoids_as_potential_analgesic_agents

And since non-narcotic drugs were mentioned above, and if you are interested, you should pay attention to the project of non-narcotic anti-cancer cannabinoids. A few years ago, science, at the highest level, received evidence of the high anticancer activity of cannabinoids, both natural and synthetic. My drug design in this case also gives substances that do not pass the lipid barrier of the brain. Moreover, they are water-soluble and convenient for injection, inhalation, ingestion and external use.

Similar cannabinoids have a pro-terpene structure and probably have good starting data, since terpene cannabinoids show good results. These drugs solve several problems at once, this is the absence of narcotic effects, because the long-term use of psychoactive cannabinoids in large doses is extremely delicate and difficult. The bioavailability of the water-soluble form improves. The possibility of using inhalation. Also, substances can be somewhat superficially active and work great on the surface of the lungs. Also, the presence of quaternary ammonium salt in the molecular structure of the drug is likely to give additional activity, such as antimicrobial, and possibly moderately cytotoxic, it is possible to adjust these new properties and obtain a harmonious drug at a new level (not several new levels). Link: https://www.academia.edu/34086585/Antitumor_anticancer_cannabinoids_terpenes_alkaloids_anthocyanins

All these projects are at the initial stage of development - design. In some cases, I experienced some things personally, speaking as a designer, chemist, and experimental animal, but these were not in-depth studies, only some refinements for moving forward. But also the initial analysis and initial estimates of projects should not have a sky-high price tag. For my part, I did everything possible to minimize the cost of project development. Many substances suggest the pathways of synthesis and the pathways of catabolism in the body. The rational drug dizan is displayed in chemical structures based on the analysis of many drugs and a large amount of information.

Moreover, some chemical structures of non-narcotic cannabinoids suggest their high activity, we are talking about dozens of micrograms. Moreover, such substances could be quite simple and not expensive in chemical synthesis. Such a coincidence of the properties of this matter gives the likelihood that a drug will be obtained whose cost will be lower than the cost of injection water in which it is dissolved. This can be a pretty big plus for mass use, given the specifics of the drug. Although even without such wonderful economic prospects, the drug is urgently needed and costs more than any money, because it relates to oncology.

Sincerely, Zaitsev Yaroslav. Email [email protected] Phone Ukraine Mobile +380(98)600-33-02 (unfortunately only Russian language, and I also apologize for possible inaccuracies in machine translation).

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nerdymedzebra · 6 years ago

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Psych appointment & Pharmacogenicomic Test Results

Saw my psychiatrist today and asked for copies of my pharmacogenomic test for my medical binder! I don't mind sharing some of the results to show folks what kind of things such a test covers.

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A post shared by nerdy zebra (@nerdyzebra) on Jul 19, 2018 at 3:35pm PDT

Caption: Saw my psychiatrist today and asked for copies of my pharmacogenomic test for my medical binder! I don't mind sharing some of the results to show folks what kind of things such a test covers. My psych ordered this genetic test for me the first time I met her, because I was on a quite high dose of Concerta (methylphenidate, aka long release ritalin) for my ADHD but it is against the policy of this mental health clinic (though the county) to give such a high dose without some proof of medical necessity. So, she ordered this test to see if genes were to blame, and she also encouraged me to get the #GastricEmptyingScan that my GI & I had already talked about getting. The problem is that, ever since I started taking ADHD meds, they just do NOT work for long for me. I had first started on Ritalin (at age 24, on college attempt #4, technically....) which was a REVELATION, but as it's short release, the effects only lasted an hour or two, which is less than what they were supposed to. So, they put me on the long release version, Concerta. Concerta too, though, only lasted about 4-5 hours, when it's supposed to last 12. AND that's only if I don't eat ANYTHING, and only drink minimal water while on it. If I eat or drink a lot, the effects seem to evaporate... [Continued on my blog, link in bio!]

My psych ordered this genetic test for me the first time I met her, because I was on a VERY high dose of Concerta (methylphenidate, aka long release ritalin) but it is against the policy of this mental health clinic (though the county) to give such a high dose without some proof of medical necessity. So, she ordered this test to see if genes were to blame, and she also encouraged me to get the gastric emptying scan that my GI & I had already talked about getting. The problem is that, ever since I started taking ADHD meds, they just do NOT work for long for me. I had first started on Ritalin (at age 24, on college attempt #4, technically....) which was a REVELATION, but as it's short release, the effects only lasted an hour or two, which is less than what they were supposed to. So, they put me on the long release version, Concerta. Concerta too, though, only lasted about 4-5 hours, when it's supposed to last 12. AND that's only if I don't eat ANYTHING, and only drink minimal water while on it. If I eat or drink a lot, the effects seem to evaporate. No doctor has known what to do about that, so by the time I finally broke down and got a cash-pay ADHD specialist when I first moved out here to CO, she ended up having me take 3 pills staggered throughout the day to *actually* try to get me through the full work day, because before, I was tanking around 2pm and my boss definitely noticed and it was becoming a problem. This doctor though, is scandalized by such a high dose, despite the fact that even THAT high dose (but each individual dose was not high) didn't even get me to 5pm, and still didn't work well at all if I ate, drank too much, and didn't have perfect sleep the night before. But I get it, policy is policy, so I'm not frustrated with her, just the system, which has a LOT of BS against ADHD adults (that's a different story for another time). So, the gastric emptying scan came back fine (as I knew it would, as I didn't have to run to the bathroom 10-15 minutes after the radioactive egg sandwich like I do after so many of my meals), and then according to her these genetic tests came back fine too. She said that, if anything, it shows that my body should require a LOWER dose than most people, yet both my ADHD meds and my Effexor (venlafaxaline, anti-depressant) doses were quite high, so she's confused. Most doctors treat adult ADHDers as drug seekers by default (i'm so trying not to go off about that..) so she's trying to help find a reason that she could use as "proof" that I need the higher dose that I do, but until we can figure that out, she can't. So, instead she's putting me on Vyvanse (lisdexamfetamine) , which I've never tried before. For the past 6/7 years I've just been on methylphenidate, so this will be my first go (more than a couple days) on a amphetamine-based med (Adderall is amphetamine salts), so I'm nervous that this new drug family just won't do anything for me, but fingers crossed. I'll take it ~3 days and then call the nurses line if I need the dose raised, which I'm sure I will, since she started me on the actually starting dose, which is suuuuper low for me. I'm open minded though. I don't care what the heck I need to take or what dose, if only it could give me my brain back! I've been 4 months without any ADHD meds, and the month before that was at drastically reduced doseage, and my life has really fallen apart in SO many ways since going off my regular meds/dose.

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battybat-boss · 7 years ago

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Newsweek: “Is Marijuana the World's Most Effective Treatment for Autism?”

Image from YouTube.

by Paul Fassa Health Impact News

On the last week of February 2018, Newsweek ran an article titled, “Is Marijuana the World's Most Effective Treatment for Autism?” The question alone was controversial. Medical marijuana for autism directly implies using cannabis on kids.

This is a shocking proposal to those who are convinced that using cannabis on kids is heinous and harmful. Another consideration widely held by those who don't know better is that using cannabis is psychotropic and shouldn't be used on minors.

But almost everyone in that group concerned about exacerbating brain disorders with cannabis are totally fine with the common practice of prescribing synthetic pharmaceuticals such as Ritalin, similar to amphetamine, and dangerous anti-psychotic drugs to young children whose behavior is even just considered socially inappropriate.

With the increasingly mounting evidence of cannabis efficacy for epilepsy, autism, and autistic children with seizures, it's time to reconsider those mind-controlled biases on cannabis for children with the steadily rising rates of autism among children whose whole families are burdened with a lifetime of intense around-the-clock expensive care.

A Single Mom's Desperation with a Severely Autistic Son In Israel

This story is the centerpiece of a Newsweek article's coverage, which leads to connecting Israeli doctors and researchers on the vanguard of applying medical cannabis to autistic children. The article did not use the surname of either the single mother, Sharon, or her autistic son Benjamin.

In 2016, Sharon, overwhelmed by her son's violent episodes of running in circles screaming, banging his head, destroying furniture, and intentionally defecating on the floor, was allowed to enroll in a Jerusalem pediatric clinical trial using a CBD to THC ratio of 20 to 1 cannabis oil on 60 low functioning aggressive self destructive autistic patients aged 5 to 21. (Source)

The ratio of CBD to THC used for this study was the same as the cannabis hybrid created by Colorado cannabis growers, especially for Charlotte Figi. At the time she was only five years old and having 300 grand mal seizures a week, often with her heart stopping.

Almost immediately after oral dosing with Charlotte's Web, her seizure rate dropped to the two to four weekly range with less heart-stopping violence. Now Charlotte at 11 is living a normal life with her twice daily small dose of Charlotte's Web oil. (Source)

Within two weeks of administering the oil orally twice a day, Benjamin began improving considerably. He was calmer and friendlier. This doesn't mean he was merely sedated. His special education teacher recommended Benjamin attend regular school at the first-grade level, normal for his six years of age. Sharon's overwhelming parental burden finally lessened. Sharon was now a mother of a normal child.

Jerusalem pediatric neurologist Dr. Adi Aran and others had already discovered that Charlotte's Web and similar strains were effective and safe for epileptic children and had been prescribing it or similar strains for epileptic children since 2013.

Some were both epileptic and autistic, which is fairly common. Among them, some had improvements in both epilepsy and autism, while a few others experienced autistic condition improvements without much relief from seizures.

Dr. Aran and others had noticed this overlap among those children he had been prescribed cannabis. So he developed the 2016 trial to include only “low functioning” severely autistic children who were seizure free. The inspiration for testing autistic children with a low THC high CBD cannabis strain was established.

“We [in the medical community] saw children with epilepsy and autism really improve, not just in their epilepsy but also in their behavior. Sometimes it was only the autism symptoms that improved,” explained Dr. Aran.

As reported by the recent Newsweek article, Dr. Adi Aran's 2016 six month trial was highly successful. In addition to Benjamin's dramatic changes, all the children showed improvement and half the 60 severe autism patients within the trial's six-month follow-up experienced dramatic reductions with core symptoms of autism, which are mainly:

1) Persistent difficulties with social communication and social interaction, which can be as severe as totally withdrawn and refusing to speak, usually referred to a non-speaking autism.

2) Restricted, repetitive patterns of behavior, interests, or activities is another autism core issue. For example, they may develop an overwhelming interest in something that ignores all else completely, they may follow inflexible routines or rituals, they may compulsively make repetitive body movements, and they may be hypersensitive to certain sounds. (Source)

Some “high functioning” autistic children may exhibit high intelligence in certain areas while “low functioning” autistic children may have very low cognitive skills and learning disabilities. The worst behavioral condition within the second core symptom may involve banging body parts against or with hard surfaces and aggressive behavior.

Full Spectrum Cannabis Not Allowed for Autism in Most USA Medical Marijuana States

Israel's national medical cannabis program is the most advanced national system in the world. Of course, its small population, currently at around 8.5 million, approximates some of our mid-size states. But just last year cannabis was prescribed to 25,000 patients with epilepsy, cancer, PTSD, pain, and other degenerative diseases.

Now Israel is pushing toward prescribing cannabis for autistic kids. With their constant searching for the right strains to match specific symptoms and almost immediately prescribing them, they are the ideal model of how to make progress with using cannabis medically for children.

However, parents of autistic children in the USA run into problems when attempting to obtain even the 20 to 1 CBD to THC ratio of cannabis oils or tinctures if their children are not suffering from epilepsy. But CBD without THC is allowed for intractable epileptic seizures even in some non-medical marijuana states.

But some seizure prone autistic children or aggressively destructive autism core types, like Benjamin in Israel, do not fully respond or respond then relapse with CBD alone. For the most part, parents of autistic children whose cases are worsening turn to cannabis for their kids on their own, underground, even “illegally” with great results.

Sometimes they're supported by medical practitioners or psychiatrists. Here's an example of one who broke the taboo of giving cannabis to her child with great results with support from a psychiatrist in California.

Marijuana Treatment for Autistic Children

youtube

It may be possible to use co-morbid conditions, such as brain damage, that are allowed for cannabis use in addition to intractable seizure. MAMMA (Mothers Advocating Medical Marijuana for Autism) is campaigning to get autism on the books as a legitimate disorder for cannabis treatments wherever medical marijuana is legal.

MAMMA co-founders Amy Lou Fawell and Thalia Michelle, both with autistic children, in one of the most medical marijuana unfriendly states, Texas, explain the resistance to their agenda is the mindset that autism is a psychological or behavioral malady, not medical, and cannabis would just create more mental disturbance and inappropriate behavior.

The DSM-5, the latest psychiatric manual for diagnosis of mental diseases states within their version of autism:

“The symptoms are not attributable to another medical or neurological condition.”

Thus most of the medical profession and the CDC simply parrot the DSM-5's observable behavioral patterns as all there is to know about autism. (Source)

Even the Charlotte's Web cannabis strain has some THC in it. And that is a “danger” of concern for most state legislators and other government officials with using it for “mental” conditions with children.

But the fact is that autism usually also has underlying medical physiological conditions. Brain scans of autistic children often show evidence of brain damage or inflammation.

Dr. Andrew Wakefield and his colleague Dr. John Walker-Smith were willing to hear what the parents of a dozen autistic children with intensely painful gastrointestinal illnesses had to say, that they were fine until their MMR vaccinations.

Their medical situation was part of their autism. Wakefield and Smith did some blood workups to confirm a link to the MMR vaccine among these kids. And all those two doctors did was write-up a clinical report about the kids and what their parents said, suggesting the MMR (mumps, measles, rubella) should be broken up into the three shots given at separate times.

But the MMR was a big seller for Glaxo-Smith Kline and Merck. What was perceived as a threat to those sales motivated an all-out attack on Dr. Wakefield, who became the target of slanderous claims that the media still supports … but that's another story, told well here.

The point is that that autism is not just a psychological condition. This notion has also made it easier for Big Pharma and mainstream media to dismiss the notion that vaccines cause autism, and difficult for government legislators and bureaucrats to grasp, especially if they still suffer from “Reefer Madness” syndrome.

Dawn Wanser explains the dilemma she had to deal with when her young son Jacob relapsed from his CBD alone induced relief. After using full spectrum cannabis with THC to restore his previously short-lived relief, Dawn explained:

“In short, high Cannabidiol (CBD) oil alone began to fail. I understand the big push on CBD oils with no presence of THC, but it's only part of the solution. Our son's life depends on all of the medicinal properties represented in the [whole] marijuana plant. (…) No, my son is not stoned or high. He is alive and he is seizure free.” (Source)

The following video presents MAMMA's case for following Israel's research lead to allow full spectrum cannabis with THC for difficult autism cases.

Cannabis for Autism: Stories of Hope

youtube

Due largely to increased vaccination demands and other toxic food and environment factors, the horror of life-long autism ruining families is constantly increasing. With mainstream medicine's failure to even moderately improve those children's quality of life, desperate parents of autistic children are gradually accepting the medicinal qualities of cannabis.

This next video features Scientist Raphael Mechoulam, the discoverer of the human endocannabinoid system and the first to isolate THC as the primary active ingredient of cannabis' healing qualities.

The video presentation is not dry and boring. It is as entertaining as it is insightful and informative, a real “must watch,” that reveals how much that's known about cannabis is withheld from public knowledge.

youtube

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lopezdorothy70-blog · 7 years ago

Text

Newsweek: “Is Marijuana the World's Most Effective Treatment for Autism?”

Image from YouTube.

by Paul Fassa Health Impact News

A Single Mom's Desperation with a Severely Autistic Son In Israel

1) Persistent difficulties with social communication and social interaction, which can be as severe as totally withdrawn and refusing to speak, usually referred to a non-speaking autism.

Full Spectrum Cannabis Not Allowed for Autism in Most USA Medical Marijuana States

Marijuana Treatment for Autistic Children

youtube

The DSM-5, the latest psychiatric manual for diagnosis of mental diseases states within their version of autism:

“The symptoms are not attributable to another medical or neurological condition.”

Thus most of the medical profession and the CDC simply parrot the DSM-5's observable behavioral patterns as all there is to know about autism. (Source)

But the fact is that autism usually also has underlying medical physiological conditions. Brain scans of autistic children often show evidence of brain damage or inflammation.

The following video presents MAMMA's case for following Israel's research lead to allow full spectrum cannabis with THC for difficult autism cases.

Cannabis for Autism: Stories of Hope

youtube

This next video features Scientist Raphael Mechoulam, the discoverer of the human endocannabinoid system and the first to isolate THC as the primary active ingredient of cannabis' healing qualities.

youtube

0 notes

fantaisie-pastorale · 7 years ago

Text

Methadone

What is it? Methadone is a synthetic opiate. It was first synthesised by German scientists during World War II because of a shortage of the morphine that was used as a painkiller. It produces similar effects to heroin or morphine. Medicinal uses Although it was originally developed for use as an analgesic, methadone is mainly used today as a substitute for heroin in an attempt to relieve some of the problems associated with heroin addiction. It is usually prescribed as a liquid syrup to be swallowed but it is also manufactured as tablets and ampoules for injection. Methadone mimics many of the effects of opiates such as heroin. Methadone maintenance programmes are intended to reduce the risks associated with heroin addicts who use illicit sources for their drugs. It is presumed that these risks – such as heroin overdose, HIV or hepatitis infection from shared syringes and risks associated with the need for criminal activity to fund illicit drug use – are reduced if addicts receive a daily supply of methadone as a substitute for illicit heroin. It is also presumed that – given a regular supply of a prescribed drug – addicts will be able to lead a more stable life, as they will no longer suffer from repeated heroin withdrawal. The effects of methadone last far longer than those of heroin or morphine. They can last up to 24 hours, which allows an opiate addict to take methadone only once a day in methadone maintenance programmes without experiencing withdrawal symptoms. The effectiveness of methadone maintenance programmes has come under question in recent years and this remains a controversial practice. Methadone can also be used for a short period to help addicts get through the physical and psychological trauma of opiate withdrawal in detoxification programmes. What effect does it have? Methadone has a similar effect to that of opiates but not as intense. The fact that it is a slow-action drug that is usually prescribed as liquid syrup means the pleasurable feelings derived from methadone are far milder than those produced by – say – injection of heroin. Although methadone produces a mild sense of well-being and relief of stress similar to that of heroin, this does not mean that methadone is a weak alternative to that drug. For it to work effectively, methadone needs to be as powerful as heroin and many addicts have stated that withdrawal from methadone is worse. Abuse of methadone Abuse of methadone can take several forms: – conning a doctor into prescribing a higher dosage than is required; – taking more than the recommended dosage; – taking methadone in combination with other drugs, including alcohol; – using methadone as a ‘top up’ drug while continuing to take heroin; – selling prescribed methadone in order to buy heroin. A serious problem with much of the methadone prescription in the past was that heroin addicts were often given sufficient methadone to last one week – or even one month. As a result, addicts commonly sold their prescribed methadone in the illicit drug market. Schoolchildren have been found in possession of this drug and several have died. It is more common practice today to require addicts on methadone maintenance programmes to collect their prescription from a clinic or pharmacy daily – and to swallow this under observation. This is to prevent methadone from entering the illicit market. In 1996 more than twice as many people died in the UK from methadone-related causes than died from taking heroin. This casts doubt on the usefulness of methadone maintenance programmes and illustrates the danger inherent in its abuse. Consequences of methadone use and abuse Consequences for health If methadone is taken as intended by the prescribing doctor it causes no damage to the physical health of the user, apart from minor symptoms such as constipation, small pupils, sweating and itchy skin. The dangers to health associated with illicit heroin or morphine – such as HIV or hepatitis infection, overdose or poisoning are not present. Taking extra methadone above the recommended dose or mixing it with other depressants such as temazepam, alcohol or even heroin is very dangerous. This can – and does – commonly result in overdose and death of the user. Withdrawal symptoms occur when a regular dosage of methadone is halted. Although these develop more slowly and are less severe than those associated with morphine and heroin withdrawal, they are more prolonged and in many respects more unpleasant. Dependence Tolerance to methadone, (where more and more of the drug must be taken to achieve the same effect) and physical/psychological dependence on the drug may occur. Anecdotal evidence appears to suggest that methadone is equally as addictive as heroin, although the attraction of injecting a ‘fix’ (a large part of psychological addiction) is not present. Legal consequences Methadone is a class A drug and it is only legal for a person to possess methadone if it has been prescribed for that individual. If prescription for an individual involves drinking the methadone syrup within the clinic or pharmacy dispensing it, possession of the drug outside of those premises would constitute an offence – it would be unlawful possession. The maximum sentence for unlawful possession of methadone is 7 years imprisonment and an unlimited fine. The maximum sentence for supplying methadone (including giving some to a friend) is life imprisonment and an unlimited fine. Methadone maintenance programmes Methadone maintenance is commonly used as a form of treatment for opiate addiction in the UK because it could break the cycle of dependence on illicit drugs like heroin. Although methadone does not produce the same ‘high’ as heroin, it does prevent withdrawal symptoms and (hopefully) reduces the craving to use other opiates. The underlying rationale of methadone maintenance is that if patients are receiving methadone, they are not inclined to seek out and buy illegal drugs on the street, or engage in criminal activities to fund illicit drug use. Also, the health risks associated with injection of illicit drugs are removed. This approach to heroin addiction is often referred to as ‘harm reduction’ or ‘harm minimisation’ as its primary aim is not so much to encourage addicts to stop using drugs but simply to attempt to reduce the damage that such use causes to addicts and society. It has been demonstrated that the probability of a methadone maintenance programme helping a heroin addict to become abstinent from all drugs – or at least find a stable lifestyle – is increased if other help, such as counselling, advice and support is also accepted. Problems associated with methadone maintenance Methadone has been accused of acting only as a palliative to the problem of heroin addiction and simply prolongs drug addiction within any individual. Prescription of a substitute for heroin offers no incentive to abstain from using drugs and many addicts simply use it as a free ‘top up’ to their existing illicit drug consumption. While methadone prescription for a short period to counteract the symptoms of heroin withdrawal must have a place in addiction treatment, its widespread use could increase the number of chemically dependent individuals. Abuse of methadone maintenance programmes is common, particularly when the drug is dispensed on a weekly basis rather than daily. Prescribed methadone is frequently encountered on the illicit market and has recently been associated with a greater number of overdose deaths than has heroin. As previously mentioned, many addicts have stated that it is physically more difficult for addicts to stop using methadone than it is to stop using heroin. While methadone maintenance does represent a low-cost form of treatment for opiate addicts (and this may be its main attraction), it offers little or no incentive for an addict to stop taking drugs. Prepared by Paul Roberts in UK http://www.darvsmith.com/dox/drugtypes.html http://eliterehaballiance.com/drug-types-from-stimulants-to-tranquilizers/

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Prepared by Paul Roberts in UK http://www.darvsmith.com/dox/drugtypes.html #Stimulants #Depressants #Analgesics #Hallucinogens #Alcohol #Amphetamines #Barbiturates #Cannabis #Cocaine #Ecstasy #GHB #Heroin #Inhalants #LSD #Methadone #’Magic’ Mushrooms #Tranquilizers

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