#analysis of drug test results

[reallytoosublime]

Join Dr. Chris Walton in this eye-opening video as he tests three popular smart drugs on two different individuals. Smart drugs, known for their claims to boost memory, focus, and learning abilities, are put to the test in a unique experiment. Dr. Walton explores the effects of Modafinal, Noopept and Piracetam on the bodies of two healthy and fit individuals.

In the first part of the video, Dr. Walton introduces Modafinal, a well-publicized smart drug used by biohackers and Silicon Valley enthusiasts. Witness the real-time reactions of one participant, Tom, as Dr. Walton applies the drug and observes its impact on Tom's stress response. The results are surprising and raise important questions about the touted benefits of these smart drugs.

As the experiment continues, Dr. Walton tests two more smart drugs, Noopept, and Piracetam, on another participant, Chris from Primal Alchemy. The outcomes are consistent across the board, revealing stress responses in all three individuals. The video emphasizes that all drugs, despite claims of cognitive enhancement, have side effects and may induce stress reactions in the body.

The video challenges common beliefs about the positive effects of smart drugs and highlights potential drawbacks, even in young and healthy individuals. Dr. Walton emphasizes the importance of caution when considering such substances and encourages viewers to question the true impact of these drugs on overall health.

This video is for informational purposes only and does not constitute medical advice. Consult with a healthcare professional before incorporating any smart drugs or nootropics into your routine.

Watch the video to gain valuable insights into the world of smart drugs and to make informed decisions about their potential effects on your well-being. Remember, not all that glitters is gold, especially when it comes to enhancing cognitive function. Stay informed, stay healthy

[twopoppies]

The article is in Spanish, but it's a very trustworthy source from Argentina. That Roger was a fucking leech, hope he rots in jail

https://www. infobae. com/sociedad/policiales/2024/11/08/pesos-argentinos-para-comprar-droga-negocios-en-comun-y-dias-libres-el-oscuro-control-de-rogelio-nores-sobre-liam-payne/

This is so fucking disturbing. I know fans have had a bad feeling about Roger for a while. It sounds like they weren’t wrong.

Today, Nores is charged with abandoning Liam Payne and killing him , as well as supplying and facilitating him with drugs, in a relationship that sources in the case describe as “almost Maradona-esque, a friend of the champion , like those who surrounded Diego at his worst .” To charge him, Madrea and his team analyzed 800 hours of footage from the CasaSur hotel and opened Liam’s phone. In addition, they took a large number of testimonies, including that of Liam’s father, Geoff Payne.

Liam's father said the same thing that the courts were able to confirm through the analysis of communications and the comparison of other testimonies: that Nores, after meeting Payne in Miami at the beginning of this year, became the force that dominated his life. If the Payne family wanted to know how the singer was, then they should contact Rogelio. He was not just another friend of Liam's, under any circumstances. Geoff Payne himself said it: "Roger" was always the intermediary. "He is better than ever," he would have told the family when asked.

And this explains the charge of abandonment of a person. It is not about the fact that the businessman did not come to the singer's aid, but about the long road that led to the CasaSur hotel.

The businessman would have become a sort of de facto manager . Although they did not have a specific contract in this regard, sources in the case say that Nores operated as an "investment advisor" and that they had business in common in view of Payne's possible return to the world stage. For this, the singer's recovery from his addiction to drugs and alcohol was key. He just had to be detoxified.

Nores accompanied Payne in a deep detoxification treatment in the United States. There, a psychiatrist prescribed sertraline, the antidepressant that was found in the toxicology test on the singer's body. The specialist said it clearly: if you mix alcohol and cocaine with sertraline, the result can be lethal.

Then, another treatment in Spain was carried out, which also failed. So they ended up in Argentina. Payne was put up in a prestigious five-star hotel that was used to hosting big rock stars. They kicked him out of there. They even visited a local psychiatrist, who testified in the file. After the five-star hotel, they both went to the Patagones polo club with the singer's last girlfriend, Kate Cassidy, where the singer was photographed wearing a helmet and heels on a horse. They spent a few days there. However, Payne quickly became nervous and left the place.

Thus, they arrived at the CasaSur hotel in Palermo on the Sunday before the death. Liam did not even have a bag. There, according to the testimonies and analysis that are part of the case of the prosecutor Madrea, Nores' control would have been much more evident, with alleged orders to the hotel staff to report each expense. Nores, this time, managed Payne's expenses , while receiving calls for each whiskey, champagne or tequila that the former One Direction member ordered, with physical money delivered at the reception. The evidence also speaks of "free days" when Liam could consume cocaine.

The day he died, precisely, was a “day off.”

Thus, Nores frequently returned to the hotel to top up the bill. Payne, meanwhile, insisted on the phone, asking for Argentine pesos to pay the dealers who offered him cocaine, with photos of the bags they offered him and the corresponding prices. The prosecution suspects that Nores had obtained cocaine for him himself, which led to the second charge against him.

Meanwhile, hotel cameras filmed Liam as he wandered the halls , drunk and with a distant look.

For the time being, Nores is free, with his passport handed over to the courts and a ban on leaving the country, while he awaits being summoned for questioning by Judge Laura Bruniard. Article 106 of the Criminal Code, which defines the crime of abandonment followed by death, speaks of “anyone who endangers the life or health of another, either by placing him or her in a situation of helplessness, or by abandoning to their fate a person who is incapable of taking care of himself or who must be maintained or cared for, or who the author himself has incapacitated .” Here, the alleged supply of narcotics plays a key role.

If convicted, he could face up to 15 years in prison. Given the amount of the sentence, the crime is not bailable.

[blusocket]

I've seen some people express some confusion about what Fortnight is about, why it opens the album, what's happening in the video, etc, so here's my attempt at an analysis. For the most part I'll be referring to the characters in the video with the names of the people playing them (Taylor and Post) but at times I'm going to be making direct reference to the events of Taylor's personal life and referring to the muses by their names (Joe and Matty) for the sake of clarity and simplicity.

The song itself uses the suburbia conceit as an extended metaphor for the beginning of her relationship with Matty (he's the neighbor she runs away to Florida with, Joe is the cheating husband.) For more eloquent and detailed thoughts on the narrative of the song you can check out Jaime @cages-boxes-hunters-foxes's post here.

The video is really dense, and I'm not 100% confident in every aspect of my interpretation, but I feel pretty sure that it's making extensive use of visual metaphor in order to tell roughly the same story as the song, just in a different setting. To start, Taylor wakes up chained to a bed in a white dress.

To me this suggests that she's been driven mad by being left at the altar, and is now trapped, surveilled and controlled, in a type of asylum. This represents the end of her relationship with Joe--waiting for a marriage that never came, feeling trapped, mentally unwell etc.

She then takes 'forget him' pills which reveal Post's tattoos on her face when she looks in the mirror.

This represents Matty (the "miracle move-on drug") and shows that he made a mark on her while she was still in the asylum--that is, still in her relationship with Joe. Additionally, in the wide shot where we see the mirror, its size and shape are very reminiscent of a one-way mirror, often seen in interrogation rooms and psychological experiments, further reinforcing the idea that Taylor is imprisoned here.

She then is able to go to the typewriter room and do her work, creating art about how she's feeling, shown by her repeatedly typing "I love you, it's ruining my life" on the typewriter. She's still in pain and feeling trapped. While there, she encounters Post and they create art together, which creates beauty and color in her life. The blue and gold obviously reference her writing about Joe, but the fact that her work is gold and Post's is blue may be a deliberate choice to draw parallels between Matty and Joe, as she does on numerous songs throughout TTPD.

The next scene, where Taylor's hair is down and she and Post are wearing the same black coat and pants, takes place inside her head (symbolized by the shape of the papers they're laying on.) She is dreaming about them being free and creating art together, represented by the papers surrounding them and book she's holding, which has the word "us" written on the cover. She's writing their story before it's begun.

She then reaches for his hand in her fantasy, accepting and asking for this relationship

Then we see that she's being studied and experimented on--the results of the lie detector test read "I love you, it's ruining my life." Her pain is an object of fascination.

Interestingly, Post is part of the group experimenting on her, but when the experiments begin to cause her pain, he liberates her.

This inspires Taylor to destroy the place where she's been trapped, which we see through her opening the filing cabinets that cover the walls and destroying the mirror. I also find the shot of her standing still while papers burn around her interesting and significant; I interpret this as Taylor destroying her own work about Joe. By choosing to leave, she is metaphorically burning--rejecting--the story she wrote about them.

Finally, Taylor and Post enter the dangerous outside world together; the rain echoes the lyric "I chose this cyclone with you" on the album's title track. While I do feel the meaning of Post being in the phone booth is somewhat ambiguous, the framing and the accompanying lyric--"I've been calling ya but you won't pick up" suggest that he's attempting to communicate with her but can't reach her. They are free of her prison, but still separated.

Then, he hangs up the phone and reaches for her hand, and she takes it. The final shot of the video is a close up on their linked hands, presenting us with a cautiously optimistic ending--they are lost and vulnerable in the middle of a storm, but they have each other.

I feel this is a somewhat less sinister, for lack of a better word, portrayal of the start of Matty and Taylor's relationship than is suggested elsewhere on the record, though I believe Post's character being part of the group experimenting on her is significant and the editing creates some ambiguity about exactly when and why she decides to break free. But I hope this clarifies how the video sets up the beginning of this story, the fallout of which is then chronicled over the course of the rest of TTPD.

[tomorrowusa]

I think that Biden should have accepted the drug test challenge – but with a major twist.

BOTH candidates should have their blood fully analyzed with the results made public.

I'd love to know what's flowing through Trump's bloodstream. Those 12 Diet Cokes® he drinks every day probably send his caffeine levels into the stratosphere. And given that Trump's White House Dr. Ronny Johnson Jackson freely distributed prescription drugs as if they were candy, it would be unusual if Trump himself had not been a recipient.

Trump’s White House Was ‘Awash in Speed’ — and Xanax

Trump bragged about his high testosterone level in an interview with Dr. Oz before he was elected. It would be enlightening to compare that 2016 level to 2024. If it's higher now, that's a sign that he's getting injections.

A Trump blood sample might also contain some interesting surprises. Trump's eating habits are even worse than those of the pre-vegan days of Bill Clinton. And Trump's father Fred had dementia for six years before he died.

Medical analysis may offer an explanation for Trump's wacky and disturbed rantings.

[macgyvermedical]

History of Lidocaine please?

Lidocaine was discovered in Sweden in the early 1940s.

About 1/3 of the surgeries at the time, including hernia repair and goiter, were done under local or regional anesthesia. The drug of choice for this was procaine. And frankly, procaine kind of sucked.

It was stored as a powder and needed to be mixed with saline and epinephrine very carefully in order to be useful. It degraded quickly in this mixture and was only effective for about 17 minutes once injected. It was also toxic at repeated or high doses. So surgeons had to be fairly quick about their surgeries.

And the room was there for a longer-acting, less toxic local anesthetic agent.

In 1943 a compound called LL30 was discovered. The lab personnel that discovered it had done a quick test on their own tongues, which anesthetized well. But it needed to be proven against procaine in both toxicity and effectiveness before a product could really be sold.

In 1944 the trials began. A man named Dr. Torsten Gordh headed up the experiments, using colleagues, patients, and students as test subjects. For the colleagues and patients, he offered the equivalent of about $16 in 2024 money to be in the study. For the students, they could choose between a copy of Gordh's thesis or a packet of American cigarettes.

Most of them chose the cigarettes.

The results were so stunningly superior to procaine that statistical analysis was never done. LL30 lasted a stunning 70 minutes compared to procaine's 17. It was also significantly less toxic, meaning more of it could be used.

LL30 would later be designated as lidocaine and sold under the brand name Xylocaine, which is still used today.

[rynnthefangirl]

Okay, so I finally got around to watching Fall of the House of Usher, and I have so many thoughts. I especially loved all the cool ways that the deaths of the siblings play into their individual characters, and I may or may not eventually do an analysis for each of them. But for right now I want to talk about one of my favorite stories and deaths in the show, Leo's.

So with Leo, everything with the cats is symbolic of his own sins plaguing him. Specifically, like many of the Ushers, Leo expects to get what he wants without bearing any responsibility for his actions, and this is exemplified by his relationship with Jules. He clearly wants to be in a relationship with Jules, and I think he does get more out of it that just sexual pleasure. However, he only cares what HE can get from the relationship, and doesn't consider his partner's desires and feelings. Leo regularly cheats on Jules, a betrayal he knows would hurt Jules but he simply does not care as long as he gets away with it. He values drugs more than he does his partner, and ignores or shuts down any discomfort or concern Jules has with his drug abuse. He won't even properly acknowledge Jules as his partner by bringing him around to meet the family, an action that would give more seriousness to their relationship and perhaps raise the expectations for how Leo should behave.

Leo's hallucination of killing Pluto is a subconscious manifestation of his failures as a boyfriend. It parallels his infidelity: he does something horrible that would break Jules' heart (fittingly as a result of drugs), and instead of feeling remorse for what he has done, he is more preoccupied with how to avoid getting caught. Except now it's no longer a girl that he can hide out on a balcony, but an irreplaceable beloved pet. Despite this severity of the situation, Leo persists in trying to hide his sins, to prioritize his own comfort and desires over honesty and trust.

So Leo goes to the pet store to find a replacement cat, and Verna is waiting for him. And this is where his test comes in, the chance to change his fate that Verna gives all the siblings. Option 1 is to leave with another cat who needs a home, and resign himself to the consequences of his crime. Had he done that, he certainly would have found that Pluto was actually unharmed, which may perhaps (although I could be excessively optimistic here) have even served as a wake up call that the drugs are becoming a problem. He would've died regardless, but he could've died peacefully and somewhat redeemed, instead of traumatizing himself and his boyfriend. Option 2 is to take the easy way out, the way that avoids all responsibility, and use his wealth and power to get the perfect replacement kitty Verna tempts him with. Leo of course, chooses the second option.

In fitting irony, Leo's attempts to avoid consequence straps him with the biggest consequence of all. The cat is seemingly out to get him, hissing and scratching as if she's directly punishing him for his choices. Interestingly, the cat herself also seems to mirror Leo. Leo satisfies himself with drugs and women, bringing them into the home he shares with Jules with no concern for Jules' feelings; the cat satisfies herself by killing small animals, bringing their corpses to the apartment with no concern for Leo's discomfort. Considering the animals as a symbol of Leo's infidelity, it's fitting that the first one is found in their bed as Jules is performing oral sex on Leo and that the discovery of it results in them being interrupted and Jules being hurt. The cat also explicitly stares down Leo in this scene, as if in judgement for him enjoying his boyfriend while he himself is unfaithful and gives nothing in return. Verna later herself explicitly draws a connection between cats and Roderick Usher, saying that they both destroy to fulfill a deficiency in themselves. The same could be said for any of the Usher children however, Leo included.

Of course, being tormented by a manifestation of his sins (combined with the drugs) begins to drive Leo insane. We see further parallels between the cat and Leo, as both suffer eye injuries at the hands of the other. Leo eventually tries to kill the cat with a hammer, which is naturally as fruitless an endeavor as taking a hammer to the abstract idea of personal failure. All he manages to destroy in his rampage is the home he shares with Jules— yes, the cat is a literal homewrecker.

I don't think Verna's choice in which cat to bring home was actually Leo's point of no return, but simply the last moment that she herself will try to intervene and convince him down another path. Even without Verna talking him down, Leo has two moments of near clarity during his rampage, both of which center around Jules. One is early on in his delusions, when he realizes that what he's seeing is crazy and muses that maybe Jules was right about the drugs. The second is when Jules comes home, and Leo realizes first that Jules cannot see the woman and cat in the wall and then that there is no woman and cat in the wall at all. In both these moments, Jules could serve as a lifeline to Leo, but to take hold of that lifeline Leo would need to put aside himself and his obsession, to ignore the cat taunting him and instead put his focus on his boyfriend. Admit that Jules was right about the drugs, admit that Jules can see more clearly than him. But Leo cannot do this. He sees the cat on the balcony, and all thoughts of Jules are wiped from his mind. He HAS to get the cat, he HAS destroy the symbol of his sins so he can continue to live free of consequence. And that final decision, that refusal to listen to Jules and put aside his immediate selfish impulses, dooms him. He flings himself right off the building, not only killing himself but emotionally destroying his boyfriend, as he was always going to do.

[nerdraging4point0]

Blood of Eden // Part Six // Noah Sebastian Urban Fantasy AU Fic

Tropes and Tags: MM, MF, MFM, MFM, instalove, too much sex, tattooed men, polyverse, shapeshifters.

CW: 18+ only minors DNI. Urban Fantasy romance, Smut. Angst. Fluff (ish), Story includes D/S themes, mentions of blood and gore, mentions of drug use and distribution, mentions of prostitution, unprotected sex, male receiving oral sex, female receiving oral sex, cuckolding, P/A sex, P/V sex.

This work below is fictionalized ideas and stories involving real people but does not directly reflect their thoughts, feelings, or behaviors. Please keep in mind that this is a work of fiction.

Active taglist: @ladyveronikawrites @tearfallpixie @beaker1636 @circle-with-me @synthetic-wasp-570 @itsjustemily @thesazzb @vinyardmauro @cookiesupplier @concreteemo @dominuslunae @mountains-to-move @sundamariis @caitcoreeeee @crimson-calligraphyx @letmeadoreyoux @starsomens @artificialbreezy @lma1986 @iknownothingpeople @lilrubles @shilohrosechicken @missduffsblog @jessicafg03 @thatchickwiththecamera @mysticdoodlez @chels3a-smile @sinkingteethinwhitenoise @deathblacksmoke @roley-poley-foley @ravieisunhinged @dethronetheveil @to-be-written @somewhere-diamond @somebodyels3 @sacredthefran @th0ughts-pr4yers @skulliecadaver-blog @hayleylatour @littlefoxkota @anameunmusical @talialovesmiw @sacredthefran @jilliemiw86 @darkmxgician

Under the haunting glow of a single desk lamp, Jolly brooded in his shadowy office, pouring himself a glass of amber liquor. Noah sat silently in the corner, shirtless, as their new plaything slept serene in the room next door.

"What do you know about her?" Jolly asked, swirling the liquid ominously.

"Nothing, master," Noah confessed into the darkness. "She broke into the lab the night we met. Oli and I hunted her down, but I can’t explain what possessed me..."

Jolly's eyes glinted knowingly. Holding up his hand to stop Noah’s rambling, "I have a theory," he uttered grimly.

Noah's brow furrowed as he rose from his seat, perching uneasily on the corner of Jolly's desk. Jolly sighed, massaging the tension from his temples before taking a long sip of whiskey. He had sensed it immediately - the moment he stepped into her apartment. Her blood was tainted. When she'd packed her bags to leave, he'd managed to retrieve the syringe from her things and sent it off for analysis. With a grave expression, he opened his email to show Noah the results.

"Nightshade. Mixed with several other chemicals to create some kind of depowering serum," he said ominously. "With the right measurements and equipment, this could mean real danger for all of us."

Jolly strokes his beard thoughtfully, his weary eyes fixed on the test results. "What troubles me is the serum has a powerful effect on her, if she were human I don’t think it would do anything other than make her violently ill.” 

Noah cocked his head to the side looking to the wall, where just on the other side she was slumbering. “She is no mage,” Jolly continued “I've searched our records and found no birth or family history for her. Without consent, I can’t trace her lineage further. And even then, the serum in her blood hinders my efforts."

Noah inquires in a gentle tone, "How long before the serum fades?"

Jolly sighed, setting his glass down on the desk, slumping in his office chair. "I can’t say for certain." His brow furrows with concern and unease over the mystery surrounding this unusual girl.

Noah tensed, his head snapping up as he swiveled to face the office door. Jolly followed his gaze, sensing what had startled him. The door creaked open and she tiptoed in, arms wrapped around herself protectively. Clad only in her underwear and a tank top, her tousled hair falling around her shoulders. Jolly glimpsed the fear in her eyes as she halted just inside the office, her wary gaze fixed on Noah. She seemed hesitant, as if ready to flee at any moment.

She froze a few steps away from the desk, her feet like lead weights refusing to carry her any closer. Noah and Rosa continued their intense gaze, oblivious to her presence. "You're real," she breathed.

Noah rose slowly from the desk, turning with deliberate caution to approach her.

"Steady now," Jolly murmured, sensing her apprehension. Though he could prevent what she was feeling, some instinct gave him pause. She shrank back as Noah neared, his imposing height and brisk stride striking fear in her, her face turning pale.

"There now, it's alright," Jolly soothed, watching as Noah gradually closed the gap between them, his towering frame looming over her trembling form. "He won’t hurt you, pretty girl."

Her limbs were trembling, arms crossing over her body attempting to steady herself. Jolly breathed in deep, letting out a sigh before turning his eyes to Noah. 

"Kneel," he ordered, his voice firm but not unkind. Noah didn’t need to look his master's way, he obeyed without hesitation, sinking to the floor. His eyes remained fixed on her, radiating the strength and compassion that allowed her to trust him completely. 

“Go ahead,” Jolly said gently. Rosa slowly unfolded her arms, her fingers grazing Noah's cheek before cradling his face in her palm. With a tender caress of her thumb across his cheekbone, Rosa's breath escaped her parted lips as understanding dawned in her soft features. Noah purred contentedly, nestling into the comfort of her touch.

“That night, on the roof,” her voice cracked. Noah's hand encircled her wrist as he gently pushed her back. In an instant, his body shifted, morphing into the form of a four-legged beast. Sitting calmly with sadness in his large, dark eyes, the hound regarded her softly. Though changed on the outside, Noah still remained within.

Covering her face in shock, she staggered backward, tripping over her own feet and crashing to the floor. Jolly shot up from his chair and rushed to her side in an instant. Noah rose to his feet, but a wave of his master's hand sent him back down, sitting on his haunches and awaiting his next command.

"No, no, no. This can't be real. Just a hallucination, a figment of my imagination. It's not possible," she muttered, shaking her head and rambling in a panic as Jolly pulled her against his chest.

"Shhh, pretty girl. Rosa, take it easy. I can explain everything," he soothed, brushing her hair with his hands as she trembled in his grasp.

Golden light from the setting sun filtered into the apartment, bathing everything in its warm glow. Noah's head rested in her lap, his eyes closed in peaceful slumber. She had been gently running her fingers through his soft brown hair for the past hour, and the soothing motion had lulled him into a deep sleep. Though her legs were starting to tingle and go numb beneath his weight, she didn't have the heart to disturb his rest. Something about watching Noah's chest rise and fall steadily filled her with tenderness. So she sat perfectly still, despite the pins and needles in her legs.

It was all almost too much for her to take in at once. Mages, magic, multiple dimensions - Jolly's revelations earlier that day had left her reeling. She had wept until she was hiccuping and gasping for breath, completely overwhelmed. Noah had simply gathered her up in his strong arms when her legs gave out, carrying her back to the plush bedroom and laying her gently on the bed. He then settled himself in her lap, a comforting presence as she continued to process everything she had learned.

He lies next to her, his chest rising and falling steadily as he drifts into slumber. The rhythm of his breathing is soothing, a balm to her fraying nerves. But even as the room darkens with the fading light, her mind continues to race, thoughts crashing together like waves breaking upon rocks. She is torn between the comfort of his presence and the chaos of her own uncertainty. His tranquility is a stark contrast to the tempest that rages within her.

The door creaks open and in steps Jolly, his features illuminated by the soft orange hues. He moves cautiously, not wanting to wake the sleeping Noah. A smile spreads across Jolly's face as he spots the two of them snuggled up together on the bed. He tiptoes over and carefully sits on the edge, gazing down at the heartwarming scene with joyful affection. The tranquil atmosphere envelops them all as the day gives way to night.

Noah's eyes fluttered open to find Jolly's kind face smiling down at him. "It's time for you to go to work," Jolly said softly, though Rosa's heart sank. She didn't want this perfect moment to end. Rosa wished Noah could stay here with her forever.

Jolly reached out, brushing his fingers against Rosa's cheek as he tucked a strand of hair behind her ear. "Don't worry," he murmured. "Noah will just be downstairs if we need him."

Noah sat up stretching his long limbs, taking her face in his large hands, his warm lips pressed softly against her forehead as he cradled her face. The tender kiss lingered for a moment before he pulled away, leaving her longing for more. Turning to Jolly, Noah placed one last gentle kiss on his master's lips. She watched wistfully as Noah hopped off the bed, stealing one final glance back into the room, his eyes filled with affection. As he disappeared down the hall, she sighed contentedly, cherishing the sweet intimacy they had just shared.

She whispers the question into the stillness of the room, her voice trembling, "Who am I now?" She does not expect a reply from Jolly, but he sighs deeply, gathering her legs into his lap. His strong hands begin massaging her feet, working out the tension that has built up within her.

"Now?" His deep voice rumbles in response. "You're here with me, sweet girl. Right by my side where I can keep you safe."

His fingertips dig into her arches, soothing away the ache she feels. "Noah and I won't let anyone or anything come for you. You belong to us. We'll protect what's ours."

His words wrap around her like a warm blanket, comforting and shielding her. A lump forming in the back of her throat, “You can’t save me from me.”

She feels her breath catch as his thoughts drift to what's coming. The moment when the shots wear off and it returns. A shiver runs through her. She doesn't want to think about it, but she can't stop the thoughts from swirling through her mind. The agony that awaits, the pain that will wrack her body. Rosa wraps her arms around herself, as if she could protect herself from what's to come. But she knows that when the medication fades, there will be no escape. The torment will find her again, just as it always does. She squeezes her eyes shut, wishing she could block it all out. But there is no blocking this out.

Jolly's voice came out in a low, predatory purr. He leaned closer to her, his dark eyes gleaming with possessiveness. "Oh yes, my precious one. I most certainly can."

The words dripped from his lips like honey, sweet yet dangerous. He looked ready to consume her, to claim her as his own. There was an alpha edge to him, a dominant protectiveness that both thrilled and frightened her. He would keep her safe, keep her close. She had no doubt.

His hands grip her thighs, parting them gently as he settles his muscular frame between her legs. She sits up on her palms before his hand presses into her chest, softly easing her back  down into the bed.

 "Easy, pretty girl," he murmurs, trailing kisses along her cheek and nose before finding her lips in a tender caress. His voice is a low rumble as he pulls back to meet her gaze. "Let me take your mind off your troubles tonight, baby. Just relax and let me make you feel good."

She wrapped her arms around his neck, pulling him against her with an urgent need. This was exhilarating yet unsettling - emotions she had never felt before. The Mage blood, Jolly had said. Magic calls to magic. The magnetic pull of her soul beckoned him, drawing her irresistibly into his orbit like a moth to a flame. He was the dominant force, exerting his gravitational power, pulling her ever closer like the moon to the earth. She felt helpless to resist, powerless against the primal attraction, needing to be one with him. His raw masculine energy called to her feminine essence, two halves of the same whole destined to unite. But it wasn’t just Jolly that consumed her with desire. It was the beast in sheep’s clothing, whose fire burned in his eyes when he looked at them both. She wanted Noah to envelope her in his strong embrace, to feel his fierce protection. The primal beast within ignited her own. This captivating man awakened something deep inside her, a connection she didn't yet understand but yearned to explore.

"How long before it wears off?" she breathes between fervent kisses, her hands hungrily roaming through his hair and down his muscular back, desperate for more of him.

"Who knows, darling," he growls in her ear, his lips trailing hot kisses down her neck as his strong hands caress her body. "Could be weeks, but one thing I do know..." He pauses to nip at her collarbone, eliciting a gasp of pleasure. "The more we get that delicious blood of yours pumping..." His fingers trail down her stomach, eliciting delicious shivers. "The faster you'll burn it off."

As Jolly’s hands glide up her torso, pushing her shirt higher, a shiver of anticipation courses through her. His touch ignites her skin, each caress stoking the fire within. “So soft,” he murmurs, trailing kisses down her neck to her chest, his warm mouth leaving a blazing trail across her flushed skin. 

With a hunger in his eyes, Jolly's hands roamed down her curves, his fingers curling around the lace of her panties. In one smooth motion, he stripped them off, exposing her fully to his ardent gaze.  Her legs wrapped around his waist as if they had a mind of their own, pulling him closer as their bodies moved together. She could feel his cock pressing against her thigh, moaning at the sweet pressure. She held him tighter, wordlessly pleading for more, and his knowing smile against her lips told her he understood.

"You want this as much as I do, don't you pretty girl?" he murmured, his nose brushing hers intimately. She nodded, their noses rubbing tenderly, ready and willing to give herself to him completely.

He gazed at her with desire burning in his eyes, his body aching to feel her surround him. "Come to me, sweet girl," he whispered hoarsely, rolling onto his back, shimmying out of his pants, and beckoning her closer.

She straddled his lap, her heart pounding as she took his thick, hard length in her hands. With gentle yet firm hands, he caressed her face, turning it so their eyes met in a moment of ecstasy. "Let me see that beautiful face as you take me in," he murmured, his voice thick with passion. Slowly she sank down, enveloping him in her velvety heat, gasping as he stretched and filled her so exquisitely. "That's it, gorgeous," Jolly rasped, his words stoking the fire within. 

She gasped as he slid into her, the friction sending sparks through her body. "You feel so good, baby," he growled, his strong hands guiding her hips. She began to rock slowly, savoring the feeling of him filling her up. His eyes were closed in ecstasy, lips parted as he held back moans. She wanted more. Her body ached for release, and she knew he needed it too, that primal urge driving him wild. She rode him harder, faster, crying out at the exquisite sensations. He thrust up into her, muscles taut, focused only on their shared pleasure. She was close, so close, his hands and body pushing her towards the edge. "Come for me," he commanded, his gravelly voice soaked in desire. She shattered around him, ecstasy crashing through her in waves. Flopping down onto his chest as she caught her breath.

"You're so beautiful," he murmured, his voice husky and low. He kissed her deeply, passionately, their tongues dancing. She was dizzy, drunk on his kisses, his touch, the way he possessed her so completely.

"Mmm, you feel so good wrapped tight around me, baby," he groaned, thrusting deep inside her dripping heat. She whimpered, lost in ecstasy as he filled her again and again. His dirty words in her ear made her clench around him.

"That's right, come for me. I want to feel you let go."

She cried out as her pleasure crested, drowning in sensation. He held her close, murmuring praise and encouragement.

"So perfect, just like that."

His lips grazed her throat, teasing her tender skin. She clung to him, gasping his name like a prayer. He increased his pace, driving into her relentlessly.

"One more, pretty girl. I know you have it in you."

His fingers found her clit, circling with just the right pressure. Her body sang, arching and tensing as she rocketed over the edge again. His groan rumbled against her body as he followed, spilling deep inside her pulsing heat.

They collapsed together, replete. He stroked her face tenderly, gazing at her with adoration.

"You good, baby?"

She nodded, smiling dreamily. He had taken her apart and put her back together again, leaving her thoroughly satisfied.

[onecornerface]

The inadequacy of non-legalization to address the overdose crisis

I’m writing a paper arguing that only drug legalization—the regulation of an accessible drug supply—has a decent chance to drastically and quickly reduce the overdose rates, at least in countries like the United States and Canada that are facing overdose crisis conditions.

Part of my argument consists in reasons to think legalization can succeed. But here I’ll discuss another part of my argument—reasons to think alternatives must fail. Legalization has a plausible mechanism for drastically & quickly reducing overdose rates, whereas all alternatives lack a plausible mechanism for doing so.

Even reformist proposals, such as decriminalization (of drug use & possession) and drug-checking (like fentanyl test-strips and centralized drug-checking services), are extremely limited in their ability to reduce death rates among the most high-risk drug users. Decriminalization is better than full prohibition, since there are no good justifications to arrest people for drug use, and it may reduce overdoses slightly through some indirect routes—but it does not address the drug supply. Drug-checking can also slightly reduce overdose and other drug hazards as well, by empowering people to manage the drug supply slightly better than they otherwise could. But it is woefully inefficient, limiting its ability to respond to the crisis at scale. I’ll describe this further on.

The source of the problem: Imperfect Prohibition One might notice that if the government ever succeeds in cracking down on all (or nearly all) the illicit drug supply, then there will be nothing left to overdose on—problem solved. So it may appear that this is a reason to continue the crackdowns against the production, trafficking, and distribution of drugs—to seek perfect prohibition.

However, this is the wrong level of analysis, appealing to an inappropriate idealization. In realistic non-ideal conditions (especially in modern countries facing an entrenched drug crisis), perfect prohibition is unattainable, and attempts to reach it will instead result in imperfect prohibition, which is the worst outcome. First, in relevant contexts, the government will most likely never succeed in eliminating all or nearly all the drug supply. Second, if an illicit market continues in operation, then it will likely continue to have extremely hazardous qualities such as high potency, volatility of dose, unmeasurableness, and frequent shifts in composition. I’ll sketch out some reasons why both of these claims are likely. And their conjunction entails that, in the absence of legalization, we will continue to have imperfect prohibition which makes the drug supply worse.

[criminal-sen]

haha jfc, it's been 7 months since I updated Imperfect... and I just barely got around to changing the WIP status from 'currently working on' to 'on temporary hiatus'

Also I have this ritual where at least once a week, I open up the doc, stare at it for a minute, then sigh and close it. Once in a blue moon, I even add a word or two, and maybe a helpful note like 'this part fucking sucks' or 'delete this part' or 'omfg just start over the entire chapter'. So there's that.

whoops I wrote way more than initially intended, including some rehab-related stuff I'm putting below a cut (nothing bad, just talking about meds and mental health stuff idk)

More usefully, the doctor at my rehab clinic finally FINALLY might be taking me seriously about the anxiety/depression shit - she's gonna get me some therapy (hopefully sooner than my primary care doc who put me on a waiting list) and also a psych analysis to see if I qualify for those anxiety meds I'm always bitching about not having. Basically I realized that if I kept telling her I was fine, nothing was ever gonna change, and the 'I'm fine' shit is entirely founded in old fears that don't even apply to me anymore??? Like, years back I was on probation - frequent drug tests and mandatory rehab were part of my conditions - so 'I'm fine' was a survival tactic to keep them off my ass as much as possible. And somewhere along the line, I completely lost any trust in rehab... which I think is a pretty valid result tbfh... but a bit counterproductive nowadays:/ So yah, the meds I want are damage control, all of this is damage control, and if I tell her there's no damage, uhhh well hopefully you see the conundrum lol

[therapyhorrorstories]

Psychiatrists will literally diagnose you within five minutes of meeting you (based on vibes, I guess?) and immediately resort to using cult tactics in order to bully you into taking medication without bothering to scientifically confirm that diagnosis. This has happened to me four times, every time it was a different diagnosis and a different medication so clearly it's not one of those "I'm an expert, I just Know" things.

And it's not like the tests don't exist, they just don't bother with them. At best they might have you self-report your symptoms in what is basically a glorified magazine quiz. My autism/ADHD diagnosis was the first time in 18 years of therapy and drugs that a professional actually diagnosed me through rigorous testing followed by statistical analysis of the results. Literally all previous diagnoses were done using either vibes or the magazine quiz method. One diagnosed me without even meeting me. Not a single one of them ever suggested autism or ADHD as possibilities, I went in for that testing on my own initiative.

The science is there but the people on the ground are too full of themselves to actually use it. Absolute shitshow of a profession.

[maaarine]

Invisible Women: Exposing Data Bias in a World Designed for Men (Caroline Criado-Perez, 2019)

"Digging deeper into the numbers, another issue the authors completely failed to address is whether or not the drugs were tested in women at different stages in their menstrual cycles.

The likelihood is that they weren’t, because most drugs aren’t.

When women are included in trials at all, they tend to be tested in the early follicular phase of their menstrual cycle, when hormone levels are at their lowest – i.e. when they are superficially most like men.

The idea is to ‘minimise the possible impacts oestradiol and progesterone may have on the study outcomes’.

But real life isn’t a study and in real life those pesky hormones will be having an impact on outcomes.

So far, menstrual-cycle impacts have been found for antipsychotics, antihistamines and antibiotic treatments as well as heart medication.

Some antidepressants have been found to affect women differently at different times of their cycle, meaning that dosage may be too high at some points and too low at others.

Women are also more likely to experience drug-induced heart-rhythm abnormalities and the risk is highest during the first half of a woman’s cycle.

This can, of course, be fatal. (…)

Perhaps most galling from a gender-data-gap perspective was the finding that females aren’t even included in animal studies on female-prevalent diseases.

Women are 70% more likely to suffer depression than men, for instance, but animal studies on brain disorders are five times as likely to be done on male animals.

A 2014 paper found that of studies on female-prevalent diseases that specified sex (44%), only 12% studied female animals.

Even when both sexes are included there is no guarantee the data will be sex-analysed: one paper reported that in studies where two sexes were included, two-thirds of the time the results were not analysed by sex.

Does this matter? Well, in the 2007 analysis of animal studies, of the few studies that did involve rats or mice of both sexes, 54% revealed sex-dependent drug effects. (…)

It’s a tantalising finding that inevitably leads to the following question: how many treatments have women missed out on because they had no effect on the male cells on which they were exclusively tested?"

[intersectingparadigms]

Forensic science - the "CSI stuff" is one of the least tested areas of the sciences there is, and deserves an overhaul. It does nothing but break peoples lives apart with false courtroom testimonies. The CSI effect means that people believe it is real when it's mostly bullshit.

Stop believing the courts every time an expert testifies. (Or at all. Most judges are cop-loving bootlickers who will gladly send you to your ruin if it speeds up their case log.)

Bite mark analysis is indisputibly fake and wrong, but courts still use it. The very first case was later proven to have had the results faked to fit, but any results after are also

Travel analysis (Where a person has been) from shoes is impossible to prove

Fingernail evidence is easy to fuck up, or confuse the courts with because many cosmetics and foods may distort findings

Hair analysis, hard to prove beyond a reasonable doubt, as it's interpretive. It uses a shitty test that can false positive hairspray or shampoo to frame people as alcoholic or drug-using (which should not be a crime). It also is used to this day. Look up Motherisk Lab for how garbage the science can be!!! None of the lab members were ever trained. This practice is same all over the world. The science is pretty bad

Fingerprints. Both not unique to each person, and the results easy to fudge. Super interpretive and hard to prove it was them or another with a similar print. Partials used as evidence too often imo

Roadside drug tests cops give? Eaaaasy to set off that mouthwash residue, aspirin, or even chewing gum can get you a positive.

DNA is also interpretive. Sure, you may be able to match it with someone, but what markers say about that person is nothing but a maybe. This is doubled or tripled as a maybe for animals - animal DNA testing is absolutely terribly regulated

Actual science welcomes challenge. Forensics often bars it, and stands by faulty labs and science that often was just imagined up as giving results by a random guy a century ago

[bbmct]

BBMCT: Begin New Medical Research at AIIMS Hospital

The world of clinical research is constantly evolving, offering new treatments, therapies, and medical innovations that have the potential to change the course of healthcare. British Biomedicine Clinical Trials (BBMCT), in partnership with AIIMS Hospital, stands as a pillar of excellence in the field of advanced clinical research. Known for its state-of-the-art facilities, skilled management, and diverse patient access, BBMCT ensures that cutting-edge medical breakthroughs are brought to life efficiently and ethically. In this article, we explore the unique advantages of collaborating with BBMCT for your clinical research needs.

## Advanced Research Facilities Available

AIIMS Hospital, one of India’s premier medical institutions, provides unparalleled infrastructure and resources for clinical trials. BBMCT leverages these advanced facilities to offer a wide range of clinical research services. The hospital is equipped with modern labs, imaging centers, and specialized units to facilitate in-depth clinical investigations. The seamless integration of research and clinical care allows for a comprehensive approach to studies, ensuring that results are both accurate and meaningful. These high-end facilities are ideal for researchers seeking to test new drugs, therapies, and medical technologies under rigorous conditions.

## Skilled Management for Clinical Trials

One of the core strengths of BBMCT is its experienced and skilled management team. From project initiation to study completion, the team at AIIMS provides expert oversight, ensuring that every aspect of the clinical trial is executed with precision and compliance. This management team includes medical professionals, research coordinators, data analysts, and regulatory experts who work collaboratively to deliver high-quality results. They manage everything from participant recruitment to data collection and analysis, ensuring that all phases of the trial proceed smoothly and meet international standards.

## Diverse Patient Population Accessed

The diversity of AIIMS’s patient population is one of the key advantages when conducting clinical trials at BBMCT. Located in the heart of India’s capital, AIIMS serves a large, varied demographic, including patients from different regions, ethnicities, and socioeconomic backgrounds. This diversity provides an invaluable opportunity to study how treatments affect different population groups. Researchers can achieve a broader, more accurate understanding of a drug’s efficacy across various age groups, genders, and underlying health conditions. This diversity also enhances the external validity of clinical trial results, making them more applicable to global populations.

## Seamless Integration of Cutting-Edge Technology

In today’s fast-paced world of medical research, the integration of advanced technology is critical to the success of clinical trials. BBMCT ensures that AIIMS Hospital is at the forefront of this technological revolution. With access to the latest tools and systems, including electronic health records (EHRs), real-time data monitoring, and artificial intelligence (AI)-driven analysis, BBMCT enhances the accuracy and efficiency of clinical trials. The use of AI allows for predictive analytics, improving patient recruitment, optimizing treatment regimens, and identifying potential risks early in the trial process. This integration of technology streamlines workflows and reduces human errors, ultimately ensuring faster and more reliable results.

## Robust Ethical Oversight Provided

Clinical research is a sensitive and often complex process that requires strict adherence to ethical guidelines. BBMCT and AIIMS Hospital place a strong emphasis on ensuring that all trials are conducted with the highest ethical standards. The hospital has an established Institutional Review Board (IRB) that oversees every study to ensure participant safety, informed consent, and confidentiality. The IRB reviews trial protocols, monitors progress, and ensures compliance with both local and international ethical standards. This robust ethical oversight provides peace of mind to both researchers and participants, making AIIMS an ideal partner for clinical trials.

## Work with Top Medical Experts

At AIIMS Hospital, clinical trials are conducted under the supervision of leading medical experts from various specialties. Whether you’re researching oncology, cardiology, neurology, or any other field, AIIMS offers access to a wide network of top-tier professionals. These experts not only provide invaluable insights into study design but also contribute to patient recruitment, data interpretation, and troubleshooting throughout the trial. By working with such highly qualified specialists, BBMCT ensures that every clinical trial is grounded in deep scientific expertise, increasing the likelihood of success and delivering innovative solutions for complex health issues.

## Efficient Processes for Quick Trials

Time is a critical factor in clinical research. BBMCT at AIIMS Hospital recognizes the importance of streamlining processes to ensure that trials are conducted efficiently and within the designated timelines. From patient recruitment to data collection and analysis, the team works to minimize delays and ensure smooth progress. The hospital’s centralized infrastructure and well-established systems help in faster recruitment, patient monitoring, and data processing. With BBMCT’s support, clinical trials can be completed quickly, without compromising on quality, making it an ideal partner for researchers looking to expedite their projects.

## Enhance Your Study’s Success Rate

The overall success rate of a clinical trial depends on many factors, including study design, patient enrollment, data collection, and analysis. BBMCT’s partnership with AIIMS Hospital enhances the likelihood of trial success through a combination of skilled management, advanced technology, and ethical oversight. The diverse patient pool, along with top medical experts, ensures that the trial results are robust and representative. Additionally, the efficient processes in place reduce the risk of delays or errors that could hinder the success of the study. Researchers working with BBMCT are well-positioned to achieve meaningful and actionable outcomes from their trials.

/media/7326bcfa7a349bf482791ea71163376c

 — -

### FAQs about BBMCT and Clinical Trials at AIIMS Hospital

**1. What is BBMCT’s role in clinical research at AIIMS Hospital?**

BBMCT acts as a trusted partner for conducting advanced clinical trials at AIIMS Hospital. It facilitates the entire process, including study design, patient recruitment, regulatory compliance, and data analysis. BBMCT ensures high-quality results by integrating cutting-edge technology, ethical oversight, and expert management to optimize the success of clinical research studies.

**2. How does BBMCT ensure ethical standards in clinical trials?**

BBMCT ensures rigorous ethical standards by adhering to national and international guidelines for clinical research. The hospital’s Institutional Review Board (IRB) thoroughly reviews each study protocol, ensures informed consent is obtained, and monitors trial progress to safeguard participant safety and confidentiality, ensuring that all trials are conducted ethically and responsibly.

**3. What type of patient population does BBMCT have access to at AIIMS?**

BBMCT benefits from the diverse and large patient population at AIIMS Hospital, which includes individuals from various regions, ethnicities, and socioeconomic backgrounds. This diversity allows researchers to assess how treatments perform across different demographic groups, ensuring that trial results are more universally applicable and increasing the external validity of the study.

**4. How does BBMCT integrate technology into clinical trials?**

BBMCT leverages advanced technologies, such as electronic health records (EHRs), AI-driven analytics, and real-time data monitoring, to enhance the efficiency and accuracy of clinical trials. These technologies streamline processes such as patient recruitment, treatment optimization, and risk monitoring, ultimately improving the speed and reliability of trial outcomes.

**5. What makes AIIMS Hospital a preferred site for clinical trials?**

AIIMS Hospital is a leading medical institution known for its world-class research facilities, skilled medical professionals, and diverse patient population. Combined with BBMCT’s expert trial management, AIIMS offers an ideal environment for conducting clinical research. The hospital’s robust infrastructure, ethical oversight, and access to top medical experts ensure that trials run smoothly and meet global standards.

 — -

## Conclusion

British Biomedicine Clinical Trials (BBMCT) at AIIMS Hospital offers a comprehensive platform for conducting high-quality clinical research. From state-of-the-art facilities to expert management and ethical oversight, BBMCT ensures that every aspect of a clinical trial is handled with precision and care. Researchers benefit from a diverse patient population, cutting-edge technology, and streamlined processes that enhance the chances of success. Working with AIIMS means gaining access to some of the top medical experts in the world, ensuring that your research is in capable hands. For those looking to begin new medical research, BBMCT at AIIMS Hospital provides the ideal setting to achieve impactful results.

Subscribe to BBMCLINICALTRIALS YouTube channel for Research Insights

Be sure to subscribe to the **BBMCLINICALTRIALS YouTube channel** for exclusive access to the latest updates and in-depth insights into British Biomedicine Clinical Trials (BBMCT). Stay informed on cutting-edge research, clinical trial advancements, patient safety protocols, and breakthrough therapies being tested at AIIMS Hospital. Our channel provides expert discussions, industry trends, and detailed videos on the clinical trial process across various therapeutic areas. Whether you’re a healthcare professional, researcher, or simply interested in biomedical innovation, subscribing will keep you at the forefront of clinical research developments. Don’t miss out — join our community today!

[religion-is-a-mental-illness]

By: Sallie Baxendale

Published: Feb 12, 2024

What happens during puberty? And what happens if we try to stop it? It’s one of the most fraught questions of our time. Given its significance and the vulnerability of the people it involves, you might be surprised to learn that there have been more studies assessing the impact of puberty blockers on cognitive function in animals than humans. Of the 16 studies that have specifically examined the impact of puberty blockers on cognitive function, 11 have been conducted in animals. And most found some detrimental impact on cognitive function when the researchers gave these drugs to mice, sheep or monkeys.

The sheep studies were particularly interesting as they used twin lambs, administering the puberty blockers to only one in the pair. More than one year after stopping the medication, the sheep who had taken the puberty blockers had still not “caught up” with their untreated siblings in their ability to complete a test of spatial memory. It can, however, be fairly argued that we can only extrapolate so much from the abilities of sheep to remember the way through a maze of hay bales. It is really the studies in humans that are of most interest to those considering prescribing or taking these drugs.

Yet such studies are hard to come by. There are only five that have looked at the impact of puberty blockers on cognitive function in children, and only three of these have looked at these effects in adolescents given the medication for gender dysphoria. In one of these studies, the researchers didn’t measure how well the children were doing before they administered the drugs, so it is difficult to know whether the subsequent difficulties they had on a strategy task could be attributed to the medication. A second study established an excellent baseline, and the researchers employed a gold-standard measure to test the cognitive abilities of the children in the programme before they started the puberty blockers.

Unfortunately, they didn’t re-administer these tests to assess the impact of the medication, but chose instead to report how many of a subset of these children completed a vocational education and how many completed a higher vocational education years later. No outcomes at all were reported on 40% of the children who started out in the study. The final study, however, was beautifully designed: the researchers assessed IQ prior to the administration of puberty blockers and regularly monitored the impact of the treatment over 28 months on a comprehensive battery of cognitive tasks. The results were concerning and suggested an overall drop in IQ of 10 points which extended to 15 points in verbal comprehension. But regrettably, this was a single case study, and while alarming, the conclusions we can draw from one person’s experience are limited.

Last year, I wrote a paper to summarise the results of these studies. The paper explained in relatively simple terms why we might think that blocking puberty in young people could impact their cognitive development. In a nutshell: puberty doesn’t just trigger the development of secondary sex characteristics; it is a really important time in the development of brain function and structure. My review of the medical literature highlighted that while there is a fairly solid scientific basis to suspect that any process that interrupts puberty will have an impact on brain development, nobody has really bothered to look at this properly in children with gender dysphoria.

I didn’t call for puberty blockers to be banned. Most medical treatments have some side effects and the choice of whether to take them depends on a careful analysis of the risk/benefit ratio for each patient. My paper didn’t conduct this kind of analysis, although others have and have judged the evidence to be so weak that these treatments can only be viewed as experimental. My summary merely provided one piece of the jigsaw. I concluded my manuscript with a list of outstanding questions and called for further research to answer these questions, as every review of the medical literature in any field always does.

As a scientific paper, it was not ground-breaking — reviews rarely are. But by summarising the research so far, I thought it would serve as a convenient resource for the numerous authorities currently examining the efficacy of these treatments. It also provided key information for parents and children currently considering medical options. Every patient needs to be aware of what doctors do and do not know about any elective treatment if they are going to make an informed decision about going ahead. Doctors have a duty of candour to provide this.

I was surprised at just how little, and how low quality, the evidence was in this field. I was also concerned that clinicians working in gender medicine continue to describe the impacts of puberty blockers as “completely physically reversible”, when it is clear that we just don’t know whether this is the case, at least with respect to the cognitive impact. But these were not the only troubling aspects of this project. The progress of this paper towards publication has been extraordinary, and unique in my three-decades-long experience of academic publishing.

The paper has now been accepted for publication in a well-respected, peer-reviewed journal. However, prior to this, the manuscript was submitted to three academic journals, all of whom rejected it. “Academic has paper rejected from journal” is not headline news. I have published many academic papers and have also served on the editorial boards of a number of high impact scientific journals. I have both delivered and received rejections. In high-quality journals, many more papers are rejected than accepted. The reasons for rejection are usually a variation on the themes that the paper isn’t telling us anything new or that the data is weak and doesn’t support the conclusions that the authors are trying to draw. In a paper that is reviewing other studies, reasons for rejection typically include criticisms of the ways the authors have looked for or selected the studies they have included in their review, with the implication that they may have missed a big chunk of evidence. Sometimes the subject of the review is too wide, too narrow or too niche to be of value to the wider readership.

While imperfect, anonymous peer review remains the foundation of scientific publishing. Theoretically, the anonymity releases reviewers from any inhibitions they may have in telling their esteemed colleagues that, on this occasion, they appear to have produced a pile of pants. When it works well, authors and editors receive a coherent critique of the submitted manuscript, with reviewers independently highlighting — and ideally converging — on the strengths and weaknesses of the paper. If done sloppily, or if the reviewers have been poorly selected, the author may be presented with a commentary on their work that is riddled with misunderstandings and inaccuracies. Requests for information already provided are common, as are suggestions that the author include reference to the anonymous reviewer’s own body of work, however tangential to the matter in hand. I have been on the receiving end of both the best and worst of these practices over the course of my career. However, I have never encountered the kinds of concerns that some of the reviewers expressed in response to my review of puberty blockers. In this case, it wasn’t the methods they objected to, it was the actual findings.

None of the reviewers identified any studies that I had missed that demonstrated safe and reversible impacts of puberty blockers on cognitive development, or presented any evidence contrary to my conclusions that the work just hasn’t been done. However, one suggested the evidence may be out there, it just hadn’t been published. They suggested that I trawl through non-peer reviewed conference presentations to look for unpublished studies that might tell a more positive story. The reviewer appeared to be under the naïve apprehension that studies proving that puberty blockers were safe and effective would have difficulty being published. The very low quality of studies in this field, and the positive spin on any results reported by gender clinicians suggest that this is unlikely to be the case.

Another reviewer expressed concerns that publishing the conclusions from these studies risked stigmatising an already stigmatised group. A third suggested that I should focus on the positive things that puberty blockers could do, while a fourth suggested there was no point in publishing a review when there wasn’t enough literature to review. Another sought to diminish an entire field of neuroscience that has established puberty as a critical period of brain development as “my view”.

In a rather telling response, one of the reviewers used religious language to criticise the paper. They argued that the sex-based terms I had employed to describe the children in the studies — natal sex, male-to-female, female-to-male — indicated a pre-existing scepticism about the use of blockers. They suggested that the very presence of these terms would cause people who prescribe these medications to “outright dismiss the article”, and went on to say that by using these terms the paper was “preaching to the choir” and would do a “poor job of attracting new members to the fold”. However, the most astonishing response I received was from a reviewer who was concerned that I appeared to be approaching the topic from a “bias” of heavy caution. This reviewer argued that lots of things needed to be sorted out before a clear case for the “riskiness” of puberty blockers could be made, even circumstantially. Indeed, they appeared to be advocating for a default position of assuming medical treatments are safe, until proven otherwise.

Yet “safe and fully reversible” can never be the default position for any medical intervention, never mind a treatment that is now deemed experimental by authorities in Europe and the UK. Extraordinary claims demand extraordinary evidence, and the only extraordinary evidence here is the gaping chasm of knowledge, or even apparent curiosity, of the clinicians who continue to chant “safe and completely reversible” as they prescribe these medications to the children in their care. It is not the job of a scientific paper to “bring people into the fold”; it is the job of clinicians to understand the evidence base of the treatments they offer and communicate this to the patients they are treating.

I sincerely hope that any arrest in brain development associated with puberty blockers is recoverable for young trans and gender diverse people, who are already facing significant challenges in their lives. I would welcome any research that indicates that this is the case, not least for the significant insights that would present to our current understanding of puberty as a critical window of neurodevelopment in adolescence. Puberty blockers almost invariably set young people on a course of lifetime medicalisation with high personal, physical and social costs. At present we cannot guarantee that cognitive costs are not added to this burden. Any clinician claiming their treatments are “safe and reversible” without evidence to back it up is failing in their fundamental duty of candour to their patients. Such an approach is unacceptable in any branch of medicine, not least that dealing with highly complex and vulnerable young people.

Sallie Baxendale is a consultant clinical neuropsychologist and a professor of clinical neuropsychology at University College London.

==

But by summarising the research so far

Therein lies the problem. "Puberty blockers are fully reversible" is an article of religious faith and recited as religious cant. Not a tested, verifiable reality. Proposing to put a spotlight on the evidence - and especially the lack thereof - is a form of religious heresy.

[hrdiagnostics-blog]

Comprehensive Guide to Urine Sample Test at H.R. Diagnostic

The Importance of Urine Sample Test for Your Health

A urine sample test is a simple yet vital diagnostic tool. It helps detect various health conditions, ranging from kidney disease to diabetes. At H.R. Diagnostic, we offer comprehensive urine tests to ensure your well-being. But why exactly is this test so important? Let’s dive into the details.

What is a Urine Sample Test?

A urine sample test analyzes your urine for various substances. These include proteins, sugars, ketones, and bacteria. Through this analysis, doctors can diagnose a wide range of medical conditions. This test is non-invasive, quick, and highly effective.

Urine tests are often part of routine checkups. However, they are also crucial when you experience specific symptoms like pain during urination or unexplained fatigue. Therefore, understanding what the test entails and how it helps can give you peace of mind.

Why Should You Get a Urine Sample Test?

Urine tests can reveal early signs of serious diseases. For instance, kidney disease often shows up in urine before any other symptoms appear. This early detection allows for prompt treatment, potentially saving you from severe complications later on.

Moreover, urine tests can monitor ongoing medical conditions. If you're diabetic or have high blood pressure, your doctor might recommend regular urine tests. These tests help track your condition and adjust treatments as necessary.

At H.R. Diagnostic, we understand that health is a priority. That's why we recommend regular urine tests as part of your health routine. We make sure your results are accurate and provide a clear picture of your health.

How Does a Urine Sample Test Work?

The process of a urine sample test is straightforward. First, you collect a small amount of urine in a sterile container. Next, this sample is analyzed in a lab. The lab looks for abnormal substances like high levels of sugar or protein, which could indicate underlying health issues.

However, not all urine tests are the same. There are different types of tests depending on what your doctor is looking for. Some common types include:

Dipstick Test: This is a quick test where a stick coated with chemicals is dipped into your urine. It changes color if certain substances are present.

Microscopic Examination: Here, your urine is examined under a microscope to check for things like bacteria or cells.

Culture Test: This test looks for bacteria or fungi that could be causing an infection.

At H.R. Diagnostic, our expert team ensures that your urine test is conducted with precision. We also explain your results clearly so you can understand what they mean for your health.

What Can a Urine Sample Test Detect?

Urine tests can detect a variety of conditions. Here are some common ones:

Kidney Disease: High levels of protein in urine can indicate kidney problems.

Diabetes: Sugar in your urine could be a sign of diabetes.

Urinary Tract Infections (UTIs): Bacteria in urine often point to a UTI.

Liver Problems: Bilirubin, a substance found in urine, can suggest liver issues.

Dehydration: Concentrated urine can be a sign that you need more fluids.

These tests are essential for diagnosing and monitoring health issues. Therefore, they should not be ignored.

How to Prepare for a Urine Sample Test

Preparation for a urine test is generally simple. However, a few tips can help ensure accurate results:

Stay Hydrated: Drink water before the test, but don't overdo it. Excessive water can dilute your urine and affect the results.

Avoid Certain Foods: Foods like beets and berries can change the color of your urine, which might confuse the test results. Try to avoid them the day before your test.

Inform Your Doctor About Medications: Some medications can interfere with test results. Therefore, make sure to inform your doctor about any drugs you're taking.

By following these guidelines, you can ensure your test results are as accurate as possible.

What Happens After the Urine Sample Test?

Once the test is done, the lab processes your sample, and the results are sent to your doctor. If your test detects any abnormalities, your doctor will discuss the next steps with you. This might involve additional tests or treatments.

At H.R. Diagnostic, we prioritize your health. Therefore, we ensure that all test results are delivered promptly. Moreover, our team is always available to discuss your results and answer any questions you may have.

Why Choose H.R. Diagnostic for Your Urine Sample Test?

At H.R. Diagnostic, we combine advanced technology with a patient-first approach. Our labs are equipped with the latest tools, ensuring your urine sample test is both accurate and reliable.

Moreover, our team of experienced professionals is dedicated to providing you with the best care possible. We understand that medical tests can be stressful, so we strive to make the process as smooth as possible.

Our commitment to quality extends beyond just the test itself. We also provide comprehensive support throughout your healthcare journey. Whether it’s explaining your results or guiding you through the next steps, we are here for you.

When Should You Get a Urine Sample Test?

You don’t have to wait until you’re sick to get a urine test. Regular health checkups often include urine tests as part of a comprehensive assessment. This is especially important if you have risk factors like high blood pressure, diabetes, or a family history of kidney disease.

However, if you experience any of the following symptoms, it’s essential to get a urine test immediately:

Frequent Urination: This could be a sign of diabetes or a UTI.

Painful Urination: This might indicate an infection or another underlying issue.

Unusual Color or Smell: This can sometimes signal dehydration or liver problems.

At H.R. Diagnostic, we offer urine tests as part of our health checkup packages. Therefore, you can easily include this test in your regular health routine.

Tips for Maintaining Urinary Health

While urine tests are crucial, maintaining good urinary health is equally important. Here are some tips to keep your urinary system healthy:

Stay Hydrated: Drink plenty of water throughout the day to keep your kidneys functioning properly.

Practice Good Hygiene: This can help prevent infections, particularly UTIs.

Limit Salt Intake: Excessive salt can strain your kidneys.

Eat a Balanced Diet: A healthy diet supports overall kidney health.

By following these tips, you can reduce your risk of urinary issues and ensure that your urine tests remain normal.

Common Misconceptions About Urine Sample Tests

Despite their importance, there are many misconceptions about urine tests. Let’s clear up a few:

Myth 1: Urine tests are only for kidney problems. Urine tests can detect a wide range of conditions, not just kidney issues. They’re useful for everything from diabetes to liver problems.

Myth 2: You don’t need a urine test if you feel fine. Many conditions show no symptoms in their early stages. Regular urine tests can catch these issues before they become serious.

Myth 3: Urine tests are always accurate. While urine tests are reliable, they aren’t perfect. Certain factors, like dehydration or medications, can affect the results. Therefore, it’s essential to follow preparation guidelines.

Conclusion: Prioritize Your Health with Regular Urine Sample Tests

A urine sample test is a simple yet powerful tool for maintaining your health. At H.R. Diagnostic, we are committed to providing top-quality urine tests that give you a clear understanding of your health status.

Regular testing, combined with a healthy lifestyle, can prevent many serious conditions. Therefore, don’t wait for symptoms to appear. Include urine tests as part of your regular health routine.

Visit H.R. Diagnostic today and take the first step toward better health. We are here to support you every step of the way.

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Author Bio: Simi Gajala has been working in digital marketing since 2018, amassing 6 years of experience. Currently Working as a Digital Marketing Executive at H.R. Diagnostics. Simi specializes in SEO, SMO, Google Ads, Meta Ads, and blogs & content writing, Boosting Brands, Increasing Visibility, And Enhancing Online Performance.

[cardiacreports2]

Autopsy Report

Case Number: 2024-1125-01 Decedent Name: Chad Evanston Age: 19 Sex: Male Height: 5’11” Weight: 154 lbs (estimated lean build) Race/Ethnicity: Caucasian Date of Death: November 24, 2024 Time of Autopsy: November 25, 2024, 9:00 AM Pathologist: Dr. Robert Linfield

I. External Examination

General Appearance: The decedent is a well-developed, lean, and athletic-appearing 19-year-old male, weighing approximately 154 pounds. He has brown hair, approximately 3 inches in length, and brown eyes. Skin is pale but otherwise unremarkable, with no evidence of external trauma or defensive injuries. Fingernails are clean and well-trimmed.

Clothing: The decedent was found dressed in athletic attire, including a blue baseball cap, black athletic shorts, a running watch on the left wrist, and well-worn running shoes. The clothing was damp due to environmental exposure but showed no tears or stains of significance beyond expected post-mortem findings.

Identifying Marks: A faint scar measuring 2 cm is present on the left knee, consistent with prior minor trauma or surgery. No tattoos or other distinguishing marks.

II. Internal Examination

Cardiovascular System: The heart is notably abnormal upon inspection. Weighing 390 grams (upper end of normal for the decedent's size and build), the heart exhibits significant thickening of the left ventricle (left ventricular hypertrophy). The mitral valve shows marked structural abnormalities, including:

Fibrotic thickening of the leaflets.

Mild calcification at the annulus.

Evidence of prolapse of the posterior leaflet, causing incomplete coaptation during closure. This structural defect resulted in significant mitral regurgitation, which would have led to reduced cardiac efficiency during exertion.

Examination of the coronary arteries reveals no signs of atherosclerosis or narrowing. However, microscopic examination identifies mild interstitial fibrosis in the ventricular myocardium, particularly in the left ventricle. These findings are consistent with chronic strain and early-stage cardiomyopathy, likely exacerbated by prolonged high-intensity physical activity.The conduction system shows mild scarring near the sinoatrial node, likely the origin of the arrhythmias detected on the decedent's running watch.

Lungs: The lungs weigh 520 grams (right) and 480 grams (left), with mild congestion. Examination shows no emboli or aspirated material.

Abdominal Organs: All abdominal organs, including the liver, spleen, kidneys, and gastrointestinal tract, appear normal in size and morphology.

Brain: Examination of the brain reveals no hemorrhages, infarcts, or structural abnormalities.

III. Microscopic Findings

Heart Tissue: Histological examination of the heart confirms chronic myocardial fibrosis and focal areas of myocyte disarray. These findings are indicative of longstanding structural abnormalities and stress-induced cardiac remodeling.

Lung Tissue: Pulmonary alveoli appear congested but otherwise unremarkable.

Valvular Tissue: Fibrosis and calcification of the mitral valve tissue are evident, along with cellular degeneration, consistent with a congenital or acquired valvular defect exacerbated over time.

IV. Toxicology Report

Testing for substances, including recreational drugs, alcohol, and common stimulants, returned negative results.

V. Cause of Death

Sudden cardiac arrest secondary to severe mitral valve dysfunction and associated arrhythmia.

Detailed Analysis of Cardiac Findings

The decedent's heart exhibited chronic and progressive mitral valve disease. The fibrotic and calcified changes in the mitral valve likely originated from an undiagnosed congenital defect, aggravated over time by physical exertion. The incomplete closure of the mitral valve resulted in backflow of blood (regurgitation) during systole, progressively overloading the left atrium and left ventricle. Over time, this stress led to the observed hypertrophy and scarring of the myocardium.

The combination of myocardial fibrosis and conduction system scarring predisposed the decedent to severe arrhythmias. The running watch data corroborates this, showing prolonged arrhythmic episodes throughout the decedent's final run.

The sustained stress of a nine-mile run caused the decedent’s heart to become electrically unstable, leading to ventricular fibrillation—a fatal arrhythmia resulting in sudden cardiac arrest. The autopsy findings, supported by wearable device data, confirm that this event was precipitated by his preexisting cardiac abnormalities.

Despite being otherwise healthy and athletic, the decedent’s heart was structurally compromised, making high-intensity exercise particularly dangerous. The mitral valve's dysfunction was significant enough that even mild to moderate exertion may have posed a risk over time.

Conclusion: Chad Evanston’s death was due to undiagnosed and progressive cardiac pathology exacerbated by prolonged physical exertion. This case highlights the critical need for screening individuals engaging in high-intensity activities for underlying heart conditions.

Final Manner of Death: Natural