#admet

[cbirt]

A vital step in drug discovery is accurately evaluating potential drug candidates’ Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET). Traditionally, this process has been time-consuming, expensive, and even limited to small compound libraries, making it difficult to test larger libraries. Recently, a group of researchers developed ADMET-AI, a simple, fast, and accurate platform for ADMET property prediction that includes both a web interface and a Python package for local prediction. It uses a graph neural network called Chemprop-RDKit, which was trained on 41 ADMET datasets from the Therapeutics Data Commons (TDC). It also surpasses existing ADMET prediction tools in terms of speed and accuracy while also providing many additional useful features. The best thing is it is free and open-source, making it a useful aid in the evaluation of large-scale chemical libraries for druglike compounds.

ADMET is an important method to predict the behavior and potential side effects of the drug in our body. For a small molecule to be at the center of a therapeutic strategy and proceed from discovery to clinical trials, the compound must possess optimal ADMET properties. Scientists can identify potential drug interactions and other effects before the drug reaches the market and then can optimize its design for better efficacy and safety.

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[hendrickdo]

Admete & Ève 🖤

[fragiledate]

la pire partie de l'affaire nekfeu c'est que les gens ont juste gobé sa réponse comme un bonbon

[whispersinthedawn]

College of Nightmares Part 2

“We thought Greek demigods died,” Ms Admete blurted out abruptly. “Greeks died and Romans retired to live out the rest of their lives in obscurity, one too powerful to survive and the other too powerless to remark on.”

Percy eyed her suspiciously. The statement seemed ripe for a rejoinder of ‘But you were wrong.’

Ms Admete voiced the criticism herself.

“But they don’t die or lead ignoble lives,” the woman continued, words spilling out of her as if water steadily widening the crack in the wall of a dam, determined to escape now that it had seen the exit.

“Monsters chase the Greeks, harry them, torture them until the stars blend into headlights and safety and danger are the same – and then they find themselves in front of someone who’ll keep them safe, who’ll teach them to defend themselves, and most importantly, who’ll allow them to pass on this gift of life unburdened by murderous monsters to another.”

It seemed a heartwarming prospect indeed – if the monsters and the saviours weren’t working in concert, if protection and destruction weren’t wrapped together in one cunning package.

“And the Romans?” Percy whispered.

The smile on Ms Admete’s face was bitterness incarnate. “You wouldn’t know,” she said with aching gentleness, with a bittersweet empathy that held nothing but an awareness of her own culpability – and how she herself was a victim of the same injustice. “The pain of being forgotten, the knowledge that everything you are is worth nothing more than a postscript in someone else’s fable.”

And still that bitter smile, as if Ms Admete knew it wasn’t enough, that no number of explanations could excuse the impending tragedy.

“To devote your whole life to the fulfilment of your purpose, only to realise that all your accomplishments just serve to relegate you to the side of everything. And it’s not as if you desire accolades or rewards for doing your duty,” Ms Admete insisted, as if wanting to make sure Percy understood, and didn’t misinterpret her grievances as something petty and born of a jealous mind.

Percy bit her lip, unable to make herself say anything.

“But acknowledgement – is that too much to ask for?” Ms Admete sighed, a plea in every inch of her body.

“A sympathetic voice, someone who understands and wants to help, who can bless you with the light of glorious purpose. Is that what was offered to the Romans?” Percy whispered. To you?

Were they still talking about the Titans? The budding power roiling underneath the seeming utopia of Olympus? Or had they moved on to the seething wreck of Gaea and her decade-long plans to subvert both the Olympians and the Titans?

Or something else altogether?

Ms Admete looked at her apologetically. “Perhaps. It certainly seemed that way, though I have no doubt most learnt, if too late, to regret attracting that kind of attention.”

But after a while, you fell in too deep, and escape meant a complete break that you could seldom gain without shattering your life into too many shards of sharp glass. Sometimes, you veered deeper and deeper until you were learning to poke out eyes from your fellow delinquents, until you were learning to flirt and cheat at cards until just the thought of anyone accepting your never-meant overtures terrified you into belligerency.

Sometimes, escape meant killing your chain and the home it was attached to, and cutting off the neck it was tied around for good measure.

(Percy had expected prison. Percy had expected staving off the police just long enough to gather the essentials and then plunging deep into the labyrinth of dark streets and apartments abandoned only during the day, and corners and alcoves that reeked of spoiling waste and lives mouldering in the spray of a river.

Percy had killed Gabe and expected to jump into the river and hide until everyone gave her up for dead.)

“Who is it?” Percy whispered. “Who frightens you so much you dare not even spell out their name?”

Ms Admete released a half-sob which she promptly stifled by pressing a fist to her mouth. “Spell it out? Lucius Domitius Ahenobarbus. That’s his name – does it help? Do you recognise him?”

No, she didn’t. But she didn’t need to, did she?

Who’s that? Percy sent out into the ether – or the polar waters that comprised her mind.

Someone Roman, Perce replied.

Someone powerful and ancient, considering the university is a century and a half old and you need a lot of money for that, Per added.

Someone in the employ of the Roman Emperors, then, since all seems to come back to them? Medea offered up half-heartedly.

Nero, Perse concluded grimly.

***

Read on Ao3

[dergunsfanblog]

HeLP

Good omens s2 has me in a chokehold but the second hand embarrassment is keeping me from finishing the magic act scene OTL

[a1exkra1ie]

j'exagère souvent genre mon anglais est pas bon ouin ouin mais en vrai c'est juste que je déparle souvent et y'a des mots qui me donnent de la difficulté (je bégaie aussi mais ça ça m'arrive peu importe la langue 💀). y'a aussi ma grammaire qui est pas impeccable et ça me dérange un peu surtout quand j'arrive pas à exprimer une idée aussi clairement que je le voudrais... mais bon on sera jamais parfait

par contre je suis absolument pas satisfait de mon accent anglais je le trouve terrible même si ça passe... mais pour moi c'est juste pas bon 😭 (et si j'entends quelqu'un qui parle comme moi je trouve ça correct... comment on appelle ça un double standard mais contre soi-même? dbjsdbsjb)

[lemondeabicyclette]

VAUT MIEUX ADMETTRE

QUE T'AS PRIS

LA MAUVAISE PORTE

QUE DE PASSER

TA VIE DANS

LA MAUVAISE PIÈCE.

[lemondeabicyclette]

🇫🇷 Paris va interdire la location de trottinettes électriques à partir du 1er septembre

La ville sera la première en Europe à appliquer cette interdiction. La Mairie de Paris a refusé de renouveler les contrats avec les opérateurs privés (Lime, Tier, Dott) et leur a ordonné de retirer les équipements des rues de la ville.

Cette décision a été soutenue par 89 % des participants au référendum municipal. Son organisatrice, la maire de Paris Anne Hidalgo, s'était déjà prononcée elle-même contre les trottinettes électriques, estimant que leur abandon réduirait les « désagréments » sur les routes.

⭐️@BrainlessChanel

[daphwritesworld]

#11 A. Putellas— Go Fuck Yourself.

content: Top!Alexia, Bottom!Reader, hate sex, impact play (R receiving), fingering (R receiving), orgasm denial, breath play, oral (r receiving)

warnings: public sex, bathroom sex, choking, degrading language (being called a bitch lol), impact play (literally one whole spank)

synopsis: You and Alexia have this toxic cycle of fighting in public and then fucking it out in private…what happens when those worlds start to blur?

word count: 1.2k

a/n: here’s a little something i found at the bottom of my google docs. my heads been feeling a little better, so hopefully tomorrow i can get some writing done!! the new Keira content is making me go into OVULATION btw 😮‍💨 the part 2 fic ideas have been steady BREWING my friends 😩

!! 18+ MINORS DNI !!

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“Go fuck yourself, Alexia!” Those four words led you to exactly where you are right now…Bent over the sink of a nightclub, your captain behind you as her fingers piston in and out of your pussy. The LED lights of the club above you drown you in a sea of red. The color suits her, that’s all you think of as you watch her through the mirror before you. You’re drooling at how her muscles bulge out of her dress, and her hair cascades down, framing her face perfectly. Her lips reach for the back of your neck, leaving some bites in her wake as she starts fingering you faster. You swear you can feel the shake of the bass of the music inside your cunt, pushing back onto her thick digits as you chase the feeling. She’s got you wholly at her disposal, the rage burning through your veins turning into pure desire. You two always end up like this, and the girls have started taking bets on how long it’ll take you both to just finally get together.

No one can give the same spitfire back to Alexia…no one except you. She doesn’t intimidate you like most. You have no problem laughing in her face and calling her an idiot. You’ll gladly tell her off for being a bitch or going too hard on a certain team member during practice. When everyone is quiet and respectful, there you are with a smirk gracing your face and a smart-ass reply ready to be fired off your tongue. It’s like you see a challenge in getting away with pushing her buttons and driving her to the edge…Well, until she fucks you back into submission. It’s a vicious cycle that you both keep dancing around– but a welcome one at that.

“Segueix muntant els meus dits com una gossa en calor,” it comes out raspy and ends with a bite to the lobe of your ear. Her teeth pulls your skin for a second, a sharp sting settling in as she trails her lips further down.

(keep riding my fingers like a bitch in heat.)

“i’m not your bitch— ahh!” She cuts you off with a harsh thrust of her wrist. It doesn’t go unnoticed by either of you how your tits start bouncing from the force. Your hips are digging into the counter so hard you know there will be bruises there later. Little reminders of her for you to reminisce about later.

She keeps up this rougher pace, harsher words spilling from her mouth before she gets distracted by marking the back of your shoulders with hickeys. “C-Can I cum?” It comes out in a desperate plea, one Alexia can’t help but laugh at.

A deep laugh that sends vibrations through your spine. Her free hand lands a sleep on your ass before it finds home making a ponytail of your hair. She yanks it until your back is against her front, her fingers somehow reaching even deeper inside of your pussy. You can’t hold back the whimpers this time— tired of being vowed to silence by the blonde behind you. “Say it,” it’s whispered against the back of your neck.

Your brows furrow as you search your brain for what she wants, “P-Please?”

Her pace starts to slow, a smirk growing on her face shown to you through the reflection on the wall. “How nice of you, bebita. But I mean admet que ets la meva puta.”

(admit you are my bitch.)

Your wide eyes meet her sharp ones in the mirror, watching your every reaction as you process her request. “No!”

She fakes a pout at you, cooing as she kisses your shoulder before pulling her fingers out of your pussy. “That’s too bad— tenia moltes ganes de veure’t venir.”

(I was really looking forward to seeing you cum)

You turn around now that you're freed from her grip, turning her back towards you. Your arms go up around her neck, pulling her down until your lips meet. She tries to back away at first, but your lips are like a drug to Alexia. Always there to drag her back down into this spiral of fighting, fucking, and repeat. She groans into your mouth when one of your hands pulls at the hair around the nape of her neck. She responds with a bite to your lower lip, dragging it away as she pulls back to put a hand back around your neck. Her other one falls to your waist, pushing you until your back hits the counter. It takes about 0.2 seconds for her to lift you up and set you on it, your legs spreading to make room for her on instinct. Her fingers find their way back inside you, three slipping in this time instead of two.

A shuttered gasp escapes you as she stretches out your cunt. You can hear the sounds of it now— the wet noises filling up the space over the music as Alexia uses her body weight to help her pound her fingers into you. She squeezes her hand around your neck, cutting off your air as she fucks you stupid. Your high is approaching faster this time, hurling towards you at the spread of light. Your legs start to shake and your pussy tightens around Alexia’s fingers.

You don’t even have to say anything for her to know you’re on the edge, she knows your body better than you at this point. Every flinch, twitch, grind, gasp, or whimper has a special code that only Alexia knows how to crack. She leans your foreheads together, “Say it or i’ll leave. Et deixaré aquí gotejant i necessitat.”

(I’ll leave you here dripping and needy.)

You find your teeth sinking into your bottom lip, trying to use every muscle in your body to hold back your orgasm as you debate the decision in your head. But as you feel her starting to slowly pull out, a loud declaration falls from your lips. “I’m your bitch! Sóc la teva petita puta!”

(I’m your little bitch!)

She surges forward at that, crashing your lips back together. “Go ahead, Cariño.”

Alexia swallows up your moans as you two keep kissing, your eyes rolling into the back of your head as she fucks you through your orgasm. You’re about to stand up and put your panties back on when she pushes your chest back. She slides your panties off around your ankle and tucks them into her purse sitting beside you on the counter. “W-What are you doing—”

“Shut up!” She growls out as she starts lowering herself between your spread legs, hands wrapping around your thighs as she keeps you held in place. “Estic intentant menjar el meu sopar.”

(I’m trying to eat my dinner.)

She licks a teasing strip up between your folds, avoiding your clit as she leans forward to press a gentle kiss to it. Alexia can feel your pussy throbbing against her puckered lips and she can’t help but groan. A hand tangles in her hair as she dives into your cunt, pulling at the perfectly styled strands as she works your overspent hole with her tongue. And as she pushes your hips further back onto the bathroom counter, your back hitting the cold glass of the mirror, you can only think one thing:

I really am Alexia’s bitch.

[coovieilledentelle]

Il y a des moments rares dans l’existence où une porte s’ouvre et où la vie t'offre une rencontre que tu n’attendais plus.

Celle de l’être complémentaire qui t'accepte telle que tu es, qui te prend dans ta globalité, qui devine et admet tes contradictions, tes peurs, ton ressentiment, ta colère, le torrent de boue sombre qui coule dans ta tête et qui l’apaise...

Celui qui te tend un miroir dans lequel tu n'as plus peur de te regarder !

~Guillaume Musso

[riotbrrrd]

J'aime bien les Antaam en tant qu'ennemis dans ce jeu. En particulier parce que j'ai choisi la faction qui a un lien de base avec eux, et du coup, ce qui est intéressant, c'est qu'ils sont d'abord pour moi une force des Qunari, une armée d'occupation dans la continuation de la guerre, et ensuite on rencontre Taash et ils se révèlent être une faction rebelle, un organe dissocié qui rejette le Qun. Ça en fait des ennemis intéressants pour Taash, par contraste avec sa mère : ils rejettent le Qun mais au final ils en ont les mêmes velléités conquérantes, ils continuent de poursuivre la même idée de grandeur, alors que Shathaan a sorti son enfant de la société Qunari pour lea protéger de cette société et du rôle qui lui serait assigné dedans, mais continue d'essayer de lui en enseigner les préceptes.

Mais du coup, plutôt que le truc gentillet d'acceptation de son identité sauce feelgood hollywoodienne, j'aurais aimé que ça représente un dilemme plus équilibré. C'est évident que Taash va pas s'allier aux Antaam, ou qu'ils ne vont pas devenir nos alliés, de par la structure du jeu, mais plutôt que de réconcilier immédiatement Taash et sa mère à base de "j'ai toujours soutenu ce que tu devenais", j'avais envie qu'ils restent énervés l'une contre l'autre assez longtemps pour que le gars qui vient dire "on chie sur le Qun, il te limite, tu pourrais devenir bien plus que ce que ta mère veut faire de toi" ait l'air de pouvoir, sinon lea convaincre, au moins faire mouche.

Pas que je fasse confiance à Bioware pour en parler bien, mais en plus ça aurait permis d'aborder même timidement ou naïvement la question de la vulnérabilité à la radicalisation, qui est ! Un truc dont on a envie que ce jeu parle ! Parce que c'est ce qui arrive à tous les alliés des dieux, et la raison même pour laquelle je suis censée m'occuper si assidûment des problèmes personnels de mon équipe c'est pas juste pour la clarté d'esprit pleine de bons sentiments que prône Emmrich mais pour l'avantage stratégique que me promettent Varric et Solas : on essaie de construire une confiance mutuelle qui peut se transformer en loyauté à même de nous protéger des tentations de pouvoir des dieux. Donc avoir un peu de marge narrative, entre l'enlèvement de Shathaan et sa mort, pour une conversation avec Taash où iel admet que le connard mascu avait l'air de lui dire ce qu'iel voulait entendre (comme on peut avoir cette conversation avec Harding après le titan, ou comme on peut voir Bellara refuser de condamner son frère) ça aurait été cool.

Et je suis quand même triste pour Shathaan, le moment est quand même triste, c'est une belle scène, c'est aussi vraiment bien et important dans le contexte de la relation de Taash avec elle, parce qu'elle est une figure omniprésente de sa vie, de lea voir pleurer et échouer à la porter et devoir l'abandonner là, c'est vraiment un délice, c'est juste que ça m'énerve que ça soit arrivé si vite et que ça ait court-circuité la réflexion que j'étais en train d'avoir sur Taash et sa relation à son identité et l'ambivalence entre sa colère et sa fragilité. Iel est un super perso bioware laissez moi passer 36 heures à décortiquer sa complexité svp

[admete]

eonveil -> admete

sorry wanted to be the water mythology mutual again

[girafeduvexin]

ÉVIDEMMENT mais on est d'accord que ce connard dit ça juste pour emmerder la gauche ? Justement parce que Mélenchon a parlé d'antisémitisme résiduel ??? C'est juste une façon de dire "non mais NOUS on admet qu'il y a de l'antisémitisme contrairement à la GAUCHE" ???? À l'aide ??????

[nemosisworld]

Il y a toujours plusieurs femmes en moi. Celle qui chute. Celle qui lutte. Celle qui dénigre. Celle qui pardonne. Celle qui comprend, admet, se résigne. Et l'autre qui se bat, espère, se passionne. Je ne sais pas combien elles sont à vrai dire. Parfois je m'y perds.

C. Soares

[craz-insanity]

Tabitha's bridesmaid ,

Gaïa Admete

( @homenumrevelio-rpg )

[coolvieilledentelle]

Il y a des moments rares dans l’existence où une porte s’ouvre et où la vie t'offre une rencontre que tu n’attendais plus.

Celle de l’être complémentaire qui t'accepte telle que tu es, qui te prend dans ta globalité, qui devine et admet tes contradictions, tes peurs, ton ressentiment, ta colère, le torrent de boue sombre qui coule dans ta tête et qui l’apaise...

Celui qui te tend un miroir dans lequel tu n'as plus peur de te regarder !

~Guillaume Musso